Abstract: The invention provides bipartite inhibitors of bacterial RNA polymerase having the general structural formula (I): X-?-Y??(I) wherein X is an moiety that binds to the rifamycin binding site of a bacterial RNA polymerase, Y is a moiety that binds to the GE23077 binding site of a bacterial RNA polymerase, and ? is a linker. The invention also provides compositions comprising such compounds, methods of making such compounds, and methods of using said compounds. The invention has applications in control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy.

Abstract: The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.

Abstract: Embodiments of the present invention disclose methods for generating a strong classifier for face detection. The methods include determining, according to a size of a prestored image training sample, a parameter of weak classifier of the image training sample, obtaining a sketch value of each of the weak classifiers of the image training sample, calculating a weighted classification error of each of the weak classifiers according to the sketch value and an initial weight of the image training sample, obtaining at least one optimal weak classifier according to the weighted classification error, and generating a strong classifier for face detection according to the optimal weak classifiers. The embodiments of the present invention further disclose an apparatus for generating a strong classifier for face detection. The embodiments of the present invention have advantages of improving robustness of code against noise and reducing a false detection rate of face detection.

Abstract: A hands-free control method for an electronic device requires a display device, a storage device, and a camera in the device. The method includes capturing an infrared image of a user's eye and a direction of gaze of a user's eye being analyzed according to the captured infrared image to determine a focus of the eye on the display device. Movements of the focus on the display device according to a previous position and a current position of the focus of the eye can be analyzed. A control instruction is generated according to a relationship between control instructions and eye movements and voice instructions can be generated based on received voice command from the user. The display device is controlled to perform predetermined actions when the voice instruction matches with the control instruction.

Abstract: A method for processing seismic data includes receiving seismic data and a velocity model (c(x)) for a plurality of locations (x), scaling a dimension of the seismic data according to the velocity model (c(x)) to provide a velocity normalized seismic data, and generating a final image (S(x)) of the subsurface using the velocity normalized seismic data. The velocity normalized seismic data may be a reverse-time migration image (I(x,?)) corresponding to the plurality of locations (x) and a plurality of propagation distance offsets (?). The method may also include transforming the reverse-time migration image (I(x,?)) for the plurality of selected positions (x) to a wavenumber domain to provide velocity normalized wavenumber data (I(k,?)) and suppressing data components corresponding to non-physical or undefined reflection angles to provide enhanced wavenumber data (I?(k,?)) and using the enhanced wavenumber data (I?(k,?)) to generate the final image (S(x)). A corresponding apparatus is also disclosed herein.

Abstract: The present invention includes methyltransferase (MTase)-defective recombinant viruses as live vaccine candidates for human metapneumovirus (hMPV), human respiratory syncytial virus (hRSV), and human parainfluenza virus type 3 (PIV3). Here the inventors provide the technical description for generating MTase-defective paramyxoviruses useful as immunogens, as well as related materials and methods.

Abstract: Provided are methods for high-throughput screening to determine locations of double-stranded DNA breaks (DSBs) and translocations in genomes caused by different agents, such as enzymes.

Abstract: A computer-implemented method includes monitoring a template registry for changes in the template registry. In response to detecting a new template in the template registry, the method includes analyzing the new template to identify explicit and implicit metadata corresponding to the new template. The method further includes determining one or more possible link dependencies between a container based on the new template and one or more other containers, respectively, based on the identified explicit and implicit metadata. In addition, the method includes providing container setting recommendations to a user based on the one or more possible link dependencies and the identified explicit and implicit metadata.

Abstract: The present disclosure describes the thermodynamic design and concentrations necessary to design probe compositions with desired optimal specificity that enable enrichment, detection, quantitation, purification, imaging, and amplification of rare-allele-bearing species of nucleic acids (prevalence <1%) in a large stoichiometric excess of a dominant-allele-bearing species (wildtype). Being an enzyme-free and homogeneous nucleic acid enrichment composition, this technology is broadly compatible with nearly all nucleic acid-based biotechnology, including plate reader and fluorimeter readout of nucleic acids, microarrays, PCR and other enzymatic amplification reactions, fluorescence barcoding, nanoparticle-based purification and quantitation, and in situ hybridization imaging technologies.

Abstract: A human machine interface (HMI) system controls operation of a graphical user interface (GUI) being displayed on a display located in a vehicle. The HMI system includes an interface device, an interface operation module, and a device selection module. The interface device is operable to control the GUI and includes a knob member and a touchpad. The interface operation module receives input data from the interface device in response to an operation of the interface device. The device selection module designates at least one of the knob member or the touchpad as an active device based on a device selection criteria. The interface operation module transmits data from an active device to a display module controlling the GUI and disregards data from an inactive device.

Abstract: A pesticidal composition comprises at least one compound selected from a 1-(3-pyridyl-N-oxide) pyrazole compound of formula I, II, or III, or any agriculturally acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R12, R13, Y, and Q, are as described herein. A method of controlling pests comprises applying the pesticidal composition near a population of pests.

Abstract: The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.

Abstract: A real-time birefringent imaging spectrometer based on differential structure is provided. A polarization beam splitter to add an imaging branch is set. Meanwhile, the structure alters the conventional optical structure to the differential structure by setting another polarization beam splitter. Taking the difference between these two interferogram obtained by two branches of differential structure as the final interferogram and performing the required post-processing calculations produces the spectrum at each pixel. Common-mode error is intensively restrained due to the differential structure, and 50% of the optical loss is avoided because of casting off the analyzer; a high spatial resolution, high spectral resolution image is acquired by combining the high spatial resolution, colorful image with the low spatial resolution, high spectral resolution image.

Abstract: The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.

Abstract: Distinct names of merchant entities in a transaction processing database are automatically corrected to standard names of entities by identifying non-standard features from the distinct names that do not uniquely identify the standard names of entities, and processing each distinct name with a selected regular expression tailored to remove the non-standard features and convent the names to a standard name format. Fuzzy matching is used to identify standard names of entities corresponding to the standard name formats.

Abstract: Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.

Abstract: There is provided a micellar particle having at least a core-shell configuration, wherein a fluorescent molecule is encapsulated within said core and wherein said shell is formed from an inorganic compound.

Abstract: The present disclosure provides an assembly structure for providing power for a chip and an electronic device using the same. The assembly structure includes: a circuit board, configured to provide a first electrical energy; a chip; and a first power converting module, configured to electrically connect the circuit board and the chip, convert the first electrical energy to a second electrical energy, and supply the second electrical energy to the chip, wherein the circuit board, the chip and the first power converting module are stacked to form the assembly structure. The present disclosure assembles a power converting module with a circuit board and a chip in a stacking manner, which may shorten a current path between the power converting module and the chip, reduce current transmission losses, improve efficiency of a system, reduce space occupancy and save system resource.

Abstract: The present invention provides a method for object segmentation in videos tagged with semantic labels, including: detecting each frame of a video sequence with an object bounding box detector from a given semantic category and an object contour detector, and obtaining a candidate object bounding box set and a candidate object contour set for each frame of the input video; building a joint assignment model for the candidate object bounding box set and the candidate object contour set and solving the model to obtain the initial object segment sequence; processing the initial object segment, to estimate a probability distribution of the object shapes; and optimizing the initial object segment sequence with a variant of graph cut algorithm that integrates the shape probability distribution, to obtain an optimal segment sequence.

Abstract: Embodiments of the present disclosure dynamically generate solution stacks. In one embodiment, a request to deploy a service in a cloud computing environment is received. A service repository is queried for data that describes one or more requirements of the service. One or more prerequisite services are identified based, at least in part, on the requirements of the service. A solution stack model is dynamically generated from (i) a stack service model of the service and (ii) the one or more prerequisite services, wherein the solution stack model is based, at least in part, on the requirements of the service.