Patents by Inventor Zenghe Liu
Zenghe Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12345671Abstract: The present disclosure provides an analyte sensor for use in detecting aspartate and/or asparagine. In certain embodiments, an aspartate-responsive active site of a presently disclosed analyte sensor includes an aspartate oxidase disposed upon a surface of a working electrode. In certain embodiments, an asparagine-responsive active site of a presently disclosed analyte sensor includes an enzyme system comprising an aspartate oxidase and an asparaginase disposed upon a surface of a working electrode. The present disclosure further provides methods for detecting aspartate and/or asparagine using the disclosed analyte sensors.Type: GrantFiled: December 23, 2021Date of Patent: July 1, 2025Assignee: Abbott Diabetes Care Inc.Inventors: Zenghe Liu, Barry S. Kreutz, Yagya Raj Ojha, Benjamin J. Feldman, Thomas P. Leary
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Patent number: 12338329Abstract: The invention discloses a method for recycling and reusing polyurethane foam. The method includes: (1) The functionalized oligomers are obtained by adding solvent and catalyst to the polyurethane foam. (2) The functionalized oligomers are chemically modified, and the photosensitive group is introduced through the functional group reaction. The diluent, photoinitiator, and light absorber, etc. are introduced into the obtained oligomers to prepare photocurable resin. It can be used for photocurable coatings or 3D printing. This method has a fast reaction time, easy recovery of solvent and catalyst, higher value-added recycled product, good economic benefits, and social value.Type: GrantFiled: December 27, 2021Date of Patent: June 24, 2025Assignee: ZHEJIANG UNIVERSITYInventors: Tao Xie, Ning Zheng, Zenghe Liu, Zizheng Fang, Qian Zhao
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Patent number: 12290355Abstract: The present disclosure provides an analyte sensor for use in detecting potassium. In certain embodiments, an analyte sensor of the present disclosure includes at least two asparagine-responsive active areas, where each asparagine-responsive active area includes an asparaginase that exhibits a particular potassium dependency. In certain embodiments, an analyte sensor of the present disclosure includes at least two aspartate-responsive active areas, where each aspartate-responsive active area includes an aspartate oxidase that exhibits a particular potassium dependency. The present disclosure further provides methods for monitoring potassium levels, e.g., in vivo potassium levels, using the disclosed analyte sensors.Type: GrantFiled: December 23, 2021Date of Patent: May 6, 2025Assignee: ABBOTT DIABETES CARE INC.Inventors: Zenghe Liu, Barry S. Kreutz, Yagya Raj Ojha, Benjamin J. Feldman, Thomas P Leary, Tram Nguyen
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Publication number: 20250049350Abstract: An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.Type: ApplicationFiled: February 16, 2024Publication date: February 13, 2025Applicant: Abbott Diabetes Care Inc.Inventors: Tianmei OUYANG, Zenghe LIU, Hyun CHO, Benjamin J. FELDMAN
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Publication number: 20250040845Abstract: The present disclosure relates to a creatinine sensor comprising a first working electrode, a creatinine sensing layer on the first working electrode comprising a redox mediator, creatinine amidohydrolase, creatine amidinohydrolase, and sarcosine oxidase, and a hydrophilic polyurethane membrane overcoating the creatinine sensing layer. The creatinine sensor can further comprise a background sensing electrode that does not detect creatinine.Type: ApplicationFiled: July 30, 2024Publication date: February 6, 2025Applicant: ABBOTT DIABETES CARE INC.Inventors: Cade FOX, Tianmei OUYANG, Yagya Raj OJHA, Zenghe LIU, Jonathan MCCANLESS, Benjamin FELDMAN
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Publication number: 20240328989Abstract: The present disclosure provides an analyte sensor comprising a working electrode, a sensing layer disposed on at least a portion of the working electrode, and a hydrophilic polyurethane membrane overcoating at least the sensing layer, wherein the hydrophilic polyurethane is aliphatic, aromatic, or both aliphatic and aromatic. The hydrophilic polyurethane membrane limits the transport of mass to the sensing layer without the need to be crosslinked. With such membrane, the analyte sensor can provide consistent analyte measurements over a temperature range of about 22-42° C. The present disclosure is further related to a method of forming an analyte sensor comprising providing a working electrode, disposing a sensing layer on at least a portion of the working electrode, and coating at least the sensing layer with a hydrophilic polyurethane membrane, wherein the hydrophilic polyurethane is aliphatic, aromatic, or both aliphatic and aromatic.Type: ApplicationFiled: January 8, 2024Publication date: October 3, 2024Applicant: ABBOTT DIABETES CARE INC.Inventors: Jonathan D. McCanless, Tianmei Ouyang, Stephen M. Oja, Yagya Raj Ojha, Rifat Emrah Ozel, Cade B. Fox, Zenghe Liu, Benjamin J. Feldman
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Publication number: 20240324913Abstract: The present invention relates to analyte sensors for use in detecting the concentration of potassium ions in a biological fluid and methods of using the sensors.Type: ApplicationFiled: March 29, 2024Publication date: October 3, 2024Inventors: Zenghe Liu, Tram Nguyen, Benjamin Feldman
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Publication number: 20240279708Abstract: The present disclosure provides analyte sensors including one or more NAD(P)-dependent enzymes and an internal supply of NAD(P) for the detection of an analyte. The present disclosure further provides methods of using such analyte sensors for detecting one or more analytes present in a biological sample of a subject, and methods of manufacturing said analyte sensors.Type: ApplicationFiled: March 6, 2024Publication date: August 22, 2024Applicant: Abbott Diabetes Care Inc.Inventors: Tianmei OUYANG, Cade FOX, Zenghe LIU, Stephen OJA, Benjamin J. FELDMAN
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Publication number: 20240268722Abstract: Method and system for determining real time analyte concentration including an analyte sensor having a portion in fluid contact with an interstitial fluid under a skin layer, an on-body electronics including a housing coupled to the analyte sensor and configured for positioning on the skin layer, the on-body electronics housing including a plurality of electrical contacts, on the housing; and a data analysis unit having a data analysis unit housing and a plurality of probes, on the housing. Each of the probes configured to electrically couple to a respective electrical contact when the data analysis unit is positioned in physical contact with the on-body electronics. The one or more signals on the probes correspond to one or more of a substantially real time monitored analyte concentration level (MACL), MACL over a predetermined time period, or a rate of change of the MACL, or combinations thereof, are provided.Type: ApplicationFiled: April 2, 2024Publication date: August 15, 2024Inventors: Udo HOSS, Benjamin J. FELDMAN, Zenghe LIU, Hyun CHO, Benjamin M. RUSH
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Patent number: 11992313Abstract: Method and system for determining real time analyte concentration including an analyte sensor having a portion in fluid contact with an interstitial fluid under a skin layer, an on-body electronics including a housing coupled to the analyte sensor and configured for positioning on the skin layer, the on-body electronics housing including a plurality of electrical contacts , on the housing; and a data analysis unit having a data analysis unit housing and a plurality of probes , on the housing. Each of the probes configured to electrically couple to a respective electrical contact when the data analysis unit is positioned in physical contact with the on-body electronics. The one or more signals on the probes correspond to one or more of a substantially real time monitored analyte concentration level (MACL), MACL over a predetermined time period, or a rate of change of the MACL, or combinations thereof, are provided.Type: GrantFiled: May 14, 2019Date of Patent: May 28, 2024Assignee: Abbott Diabetes Care Inc.Inventors: Udo Hoss, Benjamin J. Feldman, Zenghe Liu, Hyun Cho, Benjamin M Rush
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Publication number: 20230248271Abstract: Analyte sensors are being increasingly employed for monitoring various analytes in vivo. Analyte sensors configured to monitor multiple analytes are also in development. Sufficient sensitivity for low-abundance analytes and multiple analytes having differing membrane permeability values may complicate analyte detection in some cases. Analyte sensors may feature enhancements to address one or both of these issues. Some analyte sensors may comprise a carbon working electrode comprising a dielectric substrate, one or more apertures extending through the dielectric substrate and filled with a carbon conductor pillar, a carbon conductor coating on a first face of the dielectric substrate in direct contact with each carbon conductor pillar, and one or more active areas on a second face of the dielectric substrate in electrical communication with the carbon conductor pillars.Type: ApplicationFiled: May 13, 2021Publication date: August 10, 2023Inventors: Zenghe LIU, Cade B. FOX, Jonathan D. MCCANLESS, Benjamin J. FELDMAN
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Patent number: 11565047Abstract: The present disclosure relates to relates to medication injection devices, and in particular to systems and methods for on-demand delivery of a non-liquid medication from a wearable medication injection device. Particularly, aspects of the present invention are directed to a device that includes a housing defining a chamber, a piston disposed within the chamber, a needle disposed within the chamber on a first side of the piston, an energetic material disposed within the chamber on a second side of the piston, and a medication strip disposed within the needle. The medication strip includes an injectable substance in a non-liquid form.Type: GrantFiled: January 9, 2018Date of Patent: January 31, 2023Assignee: VERILY LIFE SCIENCES LLCInventors: Zenghe Liu, Todd Whitehurst, Michael Chen, Clarissa Lui
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Publication number: 20220386906Abstract: An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.Type: ApplicationFiled: August 5, 2022Publication date: December 8, 2022Applicant: Abbott Diabetes Care, Inc.Inventors: Tianmei OUYANG, Zenghe LIU, Hyun CHO, Benjamin J. FELDMAN
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Publication number: 20220330856Abstract: Methods and devices for providing application specific integrated circuit architecture for a two electrode analyte sensor or a three electrode analyte sensor are provided. Systems and kits employing the same are also provided.Type: ApplicationFiled: November 22, 2021Publication date: October 20, 2022Inventors: Martin J. Fennell, Jean-Pierre Cole, Theodore John Kunich, Udo Hoss, Benjamin Jay Feldman, Zenghe Liu
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Patent number: 11457874Abstract: A body-mountable device includes a flexible substrate configured for mounting to a skin surface. The flexible substrate is configured to be adhered or otherwise mounted to the skin in a manner that minimally impacts activities of the body. The device includes a flexible display configured to provide indications to a user, e.g., indications of sensor readings, medical alerts, or operational states of the device. The display could be operated on a very low power budget, e.g., the display could be operated intermittently. In some examples, the display could include an e-paper display or similar low power display elements. In some examples, elements of the display, e.g., electrodes of a multi-segment display, could be formed on the flexible substrate such that additional elements of the display, e.g., a layer of display medium and a layer of transparent conductor, could be adhered or otherwise attached to the formed elements.Type: GrantFiled: October 22, 2018Date of Patent: October 4, 2022Assignee: Verily Life Sciences LLCInventors: William James Biederman, Brian Otis, Zenghe Liu, Jaclyn Leverett Wasson
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Patent number: 11439326Abstract: An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.Type: GrantFiled: January 21, 2019Date of Patent: September 13, 2022Assignee: Abbott Diabetes Care Inc.Inventors: Tianmei Ouyang, Zenghe Liu, Hyun Cho, Benjamin J. Feldman
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Publication number: 20220202327Abstract: The present disclosure provides an analyte sensor for use in detecting various analytes. In certain embodiments, an analyte-responsive active area of a presently disclosed analyte sensor includes two or more enzyme systems for detecting the analyte. The present disclosure further provides methods for detecting various analytes using the disclosed analyte sensors.Type: ApplicationFiled: January 3, 2022Publication date: June 30, 2022Applicant: ABBOTT DIABETES CARE INC.Inventors: Zenghe Liu, Benjamin J. Feldman
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Publication number: 20220205944Abstract: The present disclosure provides an analyte sensor for use in detecting aspartate and/or asparagine. In certain embodiments, an aspartate-responsive active site of a presently disclosed analyte sensor includes an aspartate oxidase disposed upon a surface of a working electrode. In certain embodiments, an asparagine-responsive active site of a presently disclosed analyte sensor includes an enzyme system comprising an aspartate oxidase and an asparaginase disposed upon a surface of a working electrode. The present disclosure further provides methods for detecting aspartate and/or asparagine using the disclosed analyte sensors.Type: ApplicationFiled: December 23, 2021Publication date: June 30, 2022Applicant: Abbott Diabetes Care Inc.Inventors: Zenghe LIU, Barry S. Kreutz, Yagya Raj Ojha, Benjamin J. Feldman, Thomas P. Leary
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Publication number: 20220192548Abstract: The present disclosure provides an analyte sensor for use in detecting potassium. In certain embodiments, an analyte sensor of the present disclosure includes at least two asparagine-responsive active areas, where each asparagine-responsive active area includes an asparaginase that exhibits a particular potassium dependency. In certain embodiments, an analyte sensor of the present disclosure includes at least two aspartate-responsive active areas, where each aspartate-responsive active area includes an aspartate oxidase that exhibits a particular potassium dependency. The present disclosure further provides methods for monitoring potassium levels, e.g., in vivo potassium levels, using the disclosed analyte sensors.Type: ApplicationFiled: December 23, 2021Publication date: June 23, 2022Applicant: Abbott Diabetes Care Inc.Inventors: Zenghe Liu, Barry S. Kreutz, Yagya Raj Ojha, Benjamin J. Feldman, Thomas P. Leary, Tram Nguyen
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Publication number: 20220186277Abstract: The present disclosure provides analyte sensors including one or more NAD(P)-dependent enzymes and an internal supply of NAD(P) for the detection of an analyte. The present disclosure further provides methods of using such analyte sensors for detecting one or more analytes present in a biological sample of a subject, and methods of manufacturing said analyte sensors.Type: ApplicationFiled: December 15, 2021Publication date: June 16, 2022Applicant: ABBOTT DIABETES CARE INC.Inventors: Tianmei Ouyang, Cade Fox, Zenghe Liu, Stephen Oja, Benjamin J. Feldman