Patents by Inventor Zenghe Liu
Zenghe Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10765353Abstract: A flexible, body-mountable analyte sensing device includes a flexible substrate configured for mounting to skin of a living body. The sensing device additionally includes a sensor probe attached to the flexible substrate and configured to penetrate the skin such that a sensor disposed on the end of the sensor probe can be exposed to an analyte in interstitial fluid. The sensor could be an electrochemical sensor that includes two or more electrodes disposed at the end of the sensor probe and configured to electrochemically detect the analyte. The sensing device is configured to display detected concentrations or other information about the analyte in the interstitial fluid. The flexible substrate of the sensing device is configured to be adhered or otherwise mounted to the skin in a manner that minimally impacts activities of the living body.Type: GrantFiled: July 2, 2015Date of Patent: September 8, 2020Assignee: Verily Life Sciences LLCInventors: William James Biederman, Brian Otis, Jaclyn Leverett Wasson, Zenghe Liu
-
Patent number: 10732435Abstract: An eye contact device including at least one of a positive terminal including a first material having a standard reduction potential that is less than a standard reduction potential of chlorine; and a negative terminal including a second material having an electrode potential that favors reduction relative to a reduction of water. A method including one of forming a positive terminal of a two terminal device in an eye contact device, the positive terminal including a first material having a standard reduction potential that is less than a standard reduction potential of chlorine; and forming a negative terminal of the two terminal device including a second material having an electrode potential that favors reduction relative to a reduction of water.Type: GrantFiled: March 3, 2015Date of Patent: August 4, 2020Assignee: Verily Life Sciences LLCInventor: Zenghe Liu
-
Publication number: 20200205706Abstract: An analyte sensor comprising: an insertion tip configured for insertion below a tissue of a user, the insertion tip comprising: a working electrode comprising a sensing layer disposed thereon and a membrane layer disposed at least partially over the sensing layer; a substrate; and a counter electrode. Wherein a polymer layer comprising at least an immunosuppressant is disposed on an exterior surface of the working electrode, the substrate, or the counter electrode, the polymer layer being separate from the sensing layer and the membrane layer.Type: ApplicationFiled: March 11, 2020Publication date: July 2, 2020Applicant: Abbott Diabetes Care Inc.Inventors: Benjamin J. Feldman, Zenghe Liu
-
Patent number: 10670887Abstract: An eye-mountable device includes a lens enclosure, an anterior conductive electrode, a posterior conductive electrode, and an accommodation actuator element. The lens enclosure includes an anterior layer and a posterior layer. The anterior conductive electrode is disposed within the lens enclosure and across a center region of the lens enclosure. The posterior conductive electrode is disposed within the lens enclosure and across the center region. The accommodation actuator element is disposed within the lens enclosure between the anterior and posterior conductive electrodes in the center region. The anterior and posterior conductive electrodes are transparent and electrically manipulate the accommodation actuator element.Type: GrantFiled: October 30, 2017Date of Patent: June 2, 2020Assignee: Verily Life Sciences LLCInventors: Jeffrey G. Linhardt, Zenghe Liu, Scott B. Kennedy
-
Patent number: 10631768Abstract: Generally, embodiments of the invention relate to self-powered analyte determining devices (e.g., electrochemical analyte monitoring systems) that include a working electrode, a counter electrode, and an optional resistance value, where the working electrode includes analyte sensing components and the self-powered analyte determining device spontaneously passes a current directly proportional to analyte concentration in the absence of an external power source. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.Type: GrantFiled: June 22, 2018Date of Patent: April 28, 2020Assignee: Abbott Diabetes Inc.Inventors: Benjamin J. Feldman, Zenghe Liu, Tianmei Ouyang
-
Patent number: 10512723Abstract: An example system includes a flexible substrate configured to be mounted to a skin surface. The system includes a sensor probe that has a first end attached to the flexible substrate and a second end configured to extend beneath the skin surface to contact interstitial fluid. A sensor is configured to measure a physiological property and is disposed at the second end of the sensor probe. A transmitter is attached to the flexible substrate and is configured to provide information related to sensor measurements to a controller. The controller is configured to a drug delivery rate based on the information.Type: GrantFiled: July 13, 2018Date of Patent: December 24, 2019Assignee: Verily Life Sciences LLCInventors: William James Biederman, Brian Otis, Jaclyn Leverett Wasson, Zenghe Liu
-
Publication number: 20190328295Abstract: One example device includes a housing attachable to a wearer's skin; a electrode assembly holder disposed within the housing, the electrode assembly holder comprising: a substrate; a plurality of electrical contacts formed on the substrate; and an electrode assembly electrically coupled to the plurality of electrical contacts, the electrode assembly having a planar surface and comprising: a first screen-printed electrode having first and second ends; a chemical sensing material disposed on the first end of the electrode; and a polymer coating applied to the electrode; and wherein the first end of the screen-printed electrode extends outside of the housing and wherein a second end of each electrode is electrically coupled to one electrical contact of the plurality of electrical contacts.Type: ApplicationFiled: April 22, 2019Publication date: October 31, 2019Applicant: Verily Life Sciences LLCInventors: Zenghe Liu, Todd Whitehurst, Aurang Zeb
-
Publication number: 20190274597Abstract: Method and system for determining real time analyte concentration including an analyte sensor having a portion in fluid contact with an interstitial fluid under a skin layer, an on-body electronics including a housing coupled to the analyte sensor and configured for positioning on the skin layer, the on-body electronics housing including a plurality of electrical contacts , on the housing; and a data analysis unit having a data analysis unit housing and a plurality of probes , on the housing. Each of the probes configured to electrically couple to a respective electrical contact when the data analysis unit is positioned in physical contact with the on-body electronics. The one or more signals on the probes correspond to one or more of a substantially real time monitored analyte concentration level (MACL), MACL over a predetermined time period, or a rate of change of the MACL, or combinations thereof, are provided.Type: ApplicationFiled: May 14, 2019Publication date: September 12, 2019Applicant: Abbott Diabetes Care Inc.Inventors: Udo Hoss, Benjamin J. Feldman, Zenghe Liu, Hyun Cho, Benjamin M. Rush
-
Publication number: 20190150809Abstract: An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.Type: ApplicationFiled: January 21, 2019Publication date: May 23, 2019Applicant: Abbott Diabetes Care Inc.Inventors: Tianmei Ouyang, Zenghe Liu, Hyun Cho, Benjamin J. Feldman
-
Patent number: 10292630Abstract: A flexible, body-mountable analyte sensing device includes a flexible substrate configured for mounting to skin of a living body. The sensing device additionally includes optical fiber attached to the flexible substrate and configured to penetrate the skin such that an analyte-sensitive substance disposed on the end of the optical fiber can detect an analyte in interstitial fluid. A color, fluorescence intensity, or other optical property of the analyte-sensitive substance is related to the concentration or other property of the analyte. Light reflected, scattered, fluorescently emitted, or otherwise emitted from the analyte-sensitive substance is transmitted via the optical fiber and detected by a light sensor on the flexible substrate. Such emitted light can be emitted in response to illumination of the analyte-sensitive substance via the optical fiber. The sensing device is configured to wirelessly indicate detected concentrations or other information about the analyte in the interstitial fluid.Type: GrantFiled: June 1, 2015Date of Patent: May 21, 2019Assignee: Verily Life Sciences LLCInventors: Jaclyn Leverett Wasson, William James Biederman, Zenghe Liu, Brian Otis
-
Patent number: 10285632Abstract: Method and system for determining real time analyte concentration including an analyte sensor having a portion in fluid contact with an interstitial fluid under a skin layer, an on-body electronics including a housing coupled to the analyte sensor and configured for positioning on the skin layer, the on-body electronics housing including a plurality of electrical contacts, on the housing; and a data analysis unit having a data analysis unit housing and a plurality of probes, on the housing. Each of the probes configured to electrically couple to a respective electrical contact when the data analysis unit is positioned in physical contact with the on-body electronics. The one or more signals on the probes correspond to one or more of a substantially real time monitored analyte concentration level (MACL), MACL over a predetermined time period, or a rate of change of the MACL, or combinations thereof, are provided.Type: GrantFiled: July 25, 2017Date of Patent: May 14, 2019Assignee: Abbott Diabetes Care Inc.Inventors: Udo Hoss, Benjamin J. Feldman, Zenghe Liu, Hyun Cho, Benjamin M. Rush
-
Patent number: 10251605Abstract: A flexible, body-mountable analyte sensing device includes a flexible substrate configured for mounting to skin of a living body. The sensing device additionally includes a sensor probe attached to the flexible substrate and configured to penetrate the skin such that a sensor disposed on the sensor probe can detect an analyte in interstitial fluid. The sensor probe can include an elongate extension of the flexible substrate. The sensor can be, for example, an electrochemical sensor or an optical sensor. The sensing device is configured to wirelessly indicate detected concentrations or other information about the analyte in the interstitial fluid. The flexible substrate of the sensing device is configured to be adhered or otherwise mounted to the skin in a manner that minimally impacts activities of the living body.Type: GrantFiled: February 16, 2015Date of Patent: April 9, 2019Assignee: Verily Life Sciences LLCInventors: Zenghe Liu, Brian Otis, Jaclyn Leverett Wasson, William James Biederman
-
Patent number: 10219728Abstract: An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.Type: GrantFiled: July 29, 2014Date of Patent: March 5, 2019Assignee: Abbott Diabetes Care Inc.Inventors: Tianmei Ouyang, Zenghe Liu, Hyun Cho, Benjamin J. Feldman
-
Publication number: 20190053758Abstract: A body-mountable device includes a flexible substrate configured for mounting to a skin surface. The flexible substrate is configured to be adhered or otherwise mounted to the skin in a manner that minimally impacts activities of the body. The device includes a flexible display configured to provide indications to a user, e.g., indications of sensor readings, medical alerts, or operational states of the device. The display could be operated on a very low power budget, e.g., the display could be operated intermittently. In some examples, the display could include an e-paper display or similar low power display elements. In some examples, elements of the display, e.g., electrodes of a multi-segment display, could be formed on the flexible substrate such that additional elements of the display, e.g., a layer of display medium and a layer of transparent conductor, could be adhered or otherwise attached to the formed elements.Type: ApplicationFiled: October 22, 2018Publication date: February 21, 2019Inventors: William James Biederman, Brian Otis, Zenghe Liu, Jaclyn Leverett Wasson
-
Patent number: 10201295Abstract: A body-mountable device includes a flexible substrate configured for mounting to a skin surface. The device includes an input component configured to receive inputs from a user, e.g., finger presses, swipes, motions of the sensing platform, or gestures. Received inputs could include calibration data, for example, known values of a sensed property to compare with corresponding values obtained by a sensor of the device. The device can additionally include an output component configured to provide outputs to a user. Outputs could include indications of sensor readings, medical alerts, or operational states of the device. The flexible substrate of the device is configured to be adhered or otherwise mounted to the skin in a manner that minimally impacts activities of the body.Type: GrantFiled: March 13, 2015Date of Patent: February 12, 2019Assignee: Verily Life Sciences LLCInventors: Jaclyn Leverett Wasson, Zenghe Liu, Brian Otis, William James Biederman
-
Patent number: 10190100Abstract: A modified glucose oxidase for use in a sensor for the continuous or semi-continuous monitoring of glucose is disclosed. The modified glucose oxidase may include a glucose oxidase having at least one amino group substituted with a methacrylate through a hydrophilic linker including at least one alkylene oxide unit. A glucose sensor is also disclosed. The glucose sensor includes a crosslinked, hydrophilic copolymer sensing layer in contact with a surface of an electrode, where the sensing layer includes methacrylate-derived backbone chains covalently bound to glucose oxidase through a hydrophilic linker including at least one alkylene oxide unit. Also included is a method for making the modified glucose oxidase and the glucose sensor.Type: GrantFiled: December 28, 2015Date of Patent: January 29, 2019Assignee: Verily Life Sciences LLCInventors: Zenghe Liu, Cindy Xiaoxin Zhou
-
Patent number: 10135076Abstract: A body-mountable device includes an electrochemical battery configured to provide power when exposed to an aqueous fluid. The aqueous fluid could be blood, sweat, tears, or some other bodily fluid. The electrochemical battery includes an anode that includes zinc metal and is configured to provide an electrical potential relative to a cathode when the anode and cathode are exposed to oxygen and an aqueous fluid. The electrochemical battery could provide power to electronics configured to measure a physiological parameter at a plurality of points in time, to record such measured parameters, to transmit such measured parameters to an external system, or to perform some other functions. Components of the body-mountable device could be embedded in a polymeric material configured for mounting to a surface of an eye. Components of the body-mountable device could be disposed on a flexible substrate configured for mounting to a skin surface.Type: GrantFiled: April 26, 2016Date of Patent: November 20, 2018Assignee: Verily Life Sciences LLCInventor: Zenghe Liu
-
Patent number: 10105100Abstract: A body-mountable device includes a flexible substrate configured for mounting to a skin surface. The flexible substrate is configured to be adhered or otherwise mounted to the skin in a manner that minimally impacts activities of the body. The device includes a flexible display configured to provide indications to a user, e.g., indications of sensor readings, medical alerts, or operational states of the device. The display could be operated on a very low power budget, e.g., the display could be operated intermittently. In some examples, the display could include an e-paper display or similar low power display elements. In some examples, elements of the display, e.g., electrodes of a multi-segment display, could be formed on the flexible substrate such that additional elements of the display, e.g., a layer of display medium and a layer of transparent conductor, could be adhered or otherwise attached to the formed elements.Type: GrantFiled: July 28, 2015Date of Patent: October 23, 2018Assignee: Verily Life Sciences LLCInventors: William James Biederman, Brian Otis, Zenghe Liu, Jaclyn Leverett Wasson
-
Publication number: 20180296139Abstract: Generally, embodiments of the invention relate to self-powered analyte determining devices (e.g., electrochemical analyte monitoring systems) that include a working electrode, a counter electrode, and an optional resistance value, where the working electrode includes analyte sensing components and the self-powered analyte determining device spontaneously passes a current directly proportional to analyte concentration in the absence of an external power source. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.Type: ApplicationFiled: June 22, 2018Publication date: October 18, 2018Inventors: Benjamin J. Feldman, Zenghe Liu, Tianmei Ouyang
-
Publication number: 20180252660Abstract: Provided are sensors for determining the concentration of an analyte in a sample fluid. In certain embodiments, the sensors include conductive particles and exhibit improved uniformity of distribution of one or more sensing chemistry components, increased effective working electrode surface area, and/or reduced entry of interfering components into a sample chamber of the sensor. Methods of using and manufacturing the sensors are also provided.Type: ApplicationFiled: April 27, 2018Publication date: September 6, 2018Applicant: Abbott Diabetes Care Inc.Inventors: Benjamin J. Feldman, Zenghe Liu, Tianmei Ouyang, Suyue Qian