Abstract: An iridinesulfonamide compound having isocitrate dehydrogenase 1 (IDH1) inhibitory activity, pharmaceutically acceptable salts, solvates or hydrates thereof, a pharmaceutical composition, as well as use of the compound or the pharmaceutically acceptable salts, solvates or hydrates thereof, and the pharmaceutical composition thereof in treating IDH1 mutation induced cancer.

Abstract: A method for analyzing heart rate variability, and an apparatus and use thereof, the method for analyzing heart rate variability including collecting ECG data in vitro; digitizing and denoising the ECG data; forming the processed ECG data into a sinus NN interval sequence; selecting sinus NN interval data of 4 hours in an awake state; performing MSE calculation on the sinus NN interval sequence of 4 hours in an awake state; and extracting parameters representing the complexity of a heart rate by using MSE curves. The present invention may provide accurate and efficient screening for drug-refractory epilepsy patients who are suitable for vagus nerve stimulation surgery, thus avoiding unnecessary expenses, and avoiding missing the most opportune moment for treatment. At the same time, patients suitable for VNS surgery are selected by using MSE complexity feature parameters of ECG, thus improving the overall efficacy of VNS therapy.

Abstract: A system from updating a document to include revisions made by multiple parties that includes an indexing module for building relationships between atom repositories and source files, and a mapping module builds a relationship between multiple atom repositories produced by indexing module that are associated with a same source file family. The system also includes an atom controlling module for controlling atom adding and atom splitting in the multiple atom repository in response to update, insert and delete operations of information units in the source file. The system can also include a synchronizing engine for synchronizing updates from one version of the source file to all versions of the source file in accordance with the atom controlling module that have been made by all users when be viewed by a single user.

Abstract: Provided are a sultam compound having isocitrate dehydrogenase 1 (IDH1) inhibitory activity as represented by formula I or pharmaceutically-acceptable salts, solvates or hydrates thereof, a preparation method thereof, and a pharmaceutical composition containing the compound. The compound or the pharmaceutically-acceptable salts, solvates or hydrates thereof, and the pharmaceutical composition containing the compound can be used to treat IDH1 mutation-induced cancers.

Abstract: A method and an apparatus for analyzing heart rate Variability (HRV), and use thereof are provided. A low-cost, portable and wearable signal acquisition device is utilized to acquire electrocardiography (ECG) signals of epilepsy patients for 24 hours before treatment, and a time domain index, a frequency domain index and a nonlinear index of the ECG during a long term and during a short term are calculated with a programmed HRV analysis method, and the efficacy of vagus nerve stimulation (VNS) treatment for patients with medically intractable epilepsy is accurately and efficiently predicted based on characteristic parameters for characterizing an effect level of the vagus nerve regulating the heart rate, i.e., vagus nerve activity, thereby avoiding unnecessary costs and avoiding the delay of the optimal treatment timing. In addition, the characteristic parameters obtained by the HRV analysis on the ECG may be utilized to clearly select VNS treatment indication patients.

Abstract: A text recognition method and apparatus, and a storage medium are provided. The method includes: obtaining sample text data, the sample text data comprising a plurality of sample phrases; and generating a recognition model based on the sample phrases by performing training on a plurality of training nodes. Generating the recognition model includes respectively obtaining, by each of the plurality of training nodes, recognition coefficients of the sample phrases distributed to the corresponding training node; and determining, by the plurality of training nodes, model parameters of the recognition model according to the recognition coefficients of the sample phrases. The method also includes obtaining to-be-recognized text data; inputting the text data to the recognition model; and obtaining recognized target text data output by the recognition model and corresponding to the text data.

Abstract: An iridinesulfonamide compound having isocitrate dehydrogenase 1 (IDH1) inhibitory activity, pharmaceutically acceptable salts, solvates or hydrates thereof, a pharmaceutical composition, as well as use of the compound or the pharmaceutically acceptable salts, solvates or hydrates thereof, and the pharmaceutical composition thereof in treating IDH1 mutation induced cancer.

Abstract: A system from updating a document to include revisions made by multiple parties that includes an indexing module for building relationships between atom repositories and source files, and a mapping module builds a relationship between multiple atom repositories produced by indexing module that are associated with a same source file family. The system also includes an atom controlling module for controlling atom adding and atom splitting in the multiple atom repository in response to update, insert and delete operations of information units in the source file. The system can also include a synchronizing engine for synchronizing updates from one version of the source file to all versions of the source file in accordance with the atom controlling module that have been made by all users when be viewed by a single user.

Abstract: A method and an apparatus for analyzing heart rate Variability (HRV), and use thereof are provided. A low-cost, portable and wearable signal acquisition device is utilized to acquire electrocardiography (ECG) signals of epilepsy patients for 24 hours before treatment, and a time domain index, a frequency domain index and a nonlinear index of the ECG during a long term and during a short term are calculated with a programmed HRV analysis method, and the efficacy of vagus nerve stimulation (VNS) treatment for patients with medically intractable epilepsy is accurately and efficiently predicted based on characteristic parameters for characterizing an effect level of the vagus nerve regulating the heart rate, i.e., vagus nerve activity, thereby avoiding unnecessary costs and avoiding the delay of the optimal treatment timing. In addition, the characteristic parameters obtained by the HRV analysis on the ECG may be utilized to clearly select VNS treatment indication patients.

Abstract: Provided are a sultam compound having isocitrate dehydrogenase 1 (IDH1) inhibitory activity as represented by formula I or pharmaceutically-acceptable salts, solvates or hydrates thereof, a preparation method thereof, and a pharmaceutical composition containing the compound. The compound or the pharmaceutically-acceptable salts, solvates or hydrates thereof, and the pharmaceutical composition containing the compound can be used to treat IDH1 mutation-induced cancers.

Abstract: A low-carbon self-balance cooking fume purifier includes a power system composed of a fume extraction fan, a blower fan configured to exhaust cooking fumes, an air curtain fan, a check valve actuator, a control circuit and an intelligent controller; a fume exhaust system composed of a plenum chamber, the blower fan configured to exhaust the cooking fumes, and a check valve; a silencing system composed of a fume pre-filter, a silencer, the plenum chamber, and an air curtain system; and an energy-saving system composed of an air curtain inlet duct, an air curtain outlet duct, and the air curtain fan. A stove cabinet, a disinfection cabinet and an oven or a steam cooker are integrated in the low-carbon self-balance cooking fume purifier.

Abstract: A system from updating a document to include revisions made by multiple parties that includes an indexing module for building relationships between atom repositories and source files, and a mapping module builds a relationship between multiple atom repositories produced by indexing module that are associated with a same source file family. The system also includes an atom controlling module for controlling atom adding and atom splitting in the multiple atom repository in response to update, insert and delete operations of information units in the source file. The system can also include a synchronizing engine for synchronizing updates from one version of the source file to all versions of the source file in accordance with the atom controlling module that have been made by all users when be viewed by a single user.

Abstract: Spiral wound membrane rolls and modules and methods for making such membrane rolls and modules are described, along with water extraction or water filtrations systems including the spiral wound membrane rolls and modules and the use thereof in a forward osmosis process, an assisted forward osmosis process or a pressure retarded osmosis process

Abstract: A system from updating a document to include revisions made by multiple parties that includes an indexing module for building relationships between atom repositories and source files, and a mapping module builds a relationship between multiple atom repositories produced by indexing module that are associated with a same source file family. The system also includes an atom controlling module for controlling atom adding and atom splitting in the multiple atom repository in response to update, insert and delete operations of information units in the source file. The system can also include a synchronizing engine for synchronizing updates from one version of the source file to all versions of the source file in accordance with the atom controlling module that have been made by all users when be viewed by a single user.

Abstract: A system from updating a document to include revisions made by multiple parties that includes an indexing module for building relationships between atom repositories and source files, and a mapping module builds a relationship between multiple atom repositories produced by indexing module that are associated with a same source file family. The system also includes an atom controlling module for controlling atom adding and atom splitting in the multiple atom repository in response to update, insert and delete operations of information units in the source file. The system can also include a synchronizing engine for synchronizing updates from one version of the source file to all versions of the source file in accordance with the atom controlling module that have been made by all users when be viewed by a single user.

Abstract: A die attachment apparatus for attaching a semiconductor die onto a substrate having a metallic surface comprises a material dispensing station for dispensing a bonding material onto the substrate and a die attachment station for placing the semiconductor die onto the bonding material which has been dispensed onto the substrate. An activating gas generator positioned before the die attachment station introduces activated forming gas onto the substrate in order to reduce oxides on the substrate.

Abstract: The invention provides an alginate oligosaccharide and its derivatives with the degree of polymerization ranging from 2 to 22. The alginate oligosaccharide is composed of ?-D-mannuronic acid linked by 1,4 glycosidic bonds. The derivatives with the reduced terminal in position 1 of carboxyl radical can be prepared by oxidative degradation. The invention also provides a process for preparing the alginate oligosaccharide and its derivatives, which includes the procedure that an alginate solution is reacted for 2 to 6 h in an autoclave at pH 2˜6 and the temperature of 100˜120° C., and adjusted pH to 7 after the reaction is stopped, after which the resultant oligosaccharide is oxidized in the presence of an oxidant to obtain an oxidative product. The alginate oligosaccharide and its derivatives of the invention can be used in the manufacture of a medicament for the prophylaxis and treatment of AD and diabetes.

Abstract: An unmanned aerial vehicle includes a fuselage and an arm coupled to the fuselage. The arm includes a first segment, a second segment, and a connecting assembly coupling and locking the first segment and the second segment to each other. The connecting assembly includes a first connecting member and a second connecting member. The first connecting member is rotatably coupled to one of the first segment or the second segment. The second connecting member is coupled to another one of the first segment or the second segment. The first connecting member is rotatable relative to the arm and engages with the second connecting member to lock the first segment and the second segment.

Abstract: A method for analyzing heart rate variability, and an apparatus and use thereof, the method for analyzing heart rate variability including collecting ECG data in vitro; digitizing and denoising the ECG data; forming the processed ECG data into a sinus NN interval sequence; selecting sinus NN interval data of 4 hours in an awake state; performing MSE calculation on the sinus NN interval sequence of 4 hours in an awake state; and extracting parameters representing the complexity of a heart rate by using MSE curves. The present invention may provide accurate and efficient screening for drug-refractory epilepsy patients who are suitable for vagus nerve stimulation surgery, thus avoiding unnecessary expenses, and avoiding missing the most opportune moment for treatment. At the same time, patients suitable for VNS surgery are selected by using MSE complexity feature parameters of ECG, thus improving the overall efficacy of VNS therapy.

Abstract: A method and an apparatus for analyzing heart rate Variability (HRV), and use thereof are provided. A low-cost, portable and wearable signal acquisition device is utilized to acquire electrocardiography (ECG) signals of epilepsy patients for 24 hours before treatment, and a time domain index, a frequency domain index and a nonlinear index of the ECG during a long term and during a short term are calculated with a programmed HRV analysis method, and the efficacy of vagus nerve stimulation (VNS) treatment for patients with medically intractable epilepsy is accurately and efficiently predicted based on characteristic parameters for characterizing an effect level of the vagus nerve regulating the heart rate, i.e., vagus nerve activity, thereby avoiding unnecessary costs and avoiding the delay of the optimal treatment timing. In addition, the characteristic parameters obtained by the HRV analysis on the ECG may be utilized to clearly select VNS treatment indication patients.