Abstract: The present invention provides a novel tricyclic aromatic heterocyclic compound, a preparation method therefor, a pharmaceutical composition and an application thereof. Specifically, the present invention provides a compound as represented by the following formula I, or optical isomers, hydrates, and solvates thereof, or pharmaceutically-acceptable salts thereof. Definitions of groups are as stated in the description. The compound as represented by formula I can be used for treating diseases related to a PD-1/PD-L 1 signal pathway.

Abstract: A method includes determining whether an inference framework for a deep learning inference framework supports a first data arrangement scheme of a machine learning inference model; determining, in response to the inference framework not supporting the first data arrangement scheme, a data arrangement scheme conversion strategy of input data and output data of an inference operator of the inference framework, based on a dimension of the input data received by the inference operator, a dimension of the output data output corresponding to the input data, and a correlation between the inference operator and the data arrangement scheme; and converting either a data arrangement scheme of the input data or the output data of the inference operator based on the determined data arrangement scheme conversion strategy.

Abstract: A game development method and apparatus, a game running method and apparatus, and an electronic device. The game development method comprises: receiving a development instruction for a target function of a game (S101); obtaining a target prefabricated part corresponding to the target function from a preset database on the basis of the development instruction, a plurality of prefabricated parts being pre-stored in the database, each prefabricated part corresponding to one function setting, and each prefabricated part comprising a control configured with a preset logic, an application interface, and a backend invocation cloud function (S102); and developing the target function of the game according to the target prefabricated part (S103). According to the method, the development workload can be effectively reduced, the development labor cost and the later server maintenance cost are reduced, and thus the development efficiency is effectively improved.

Abstract: The disclosure provides immunogenic cells expressing LMP1, and use thereof in activating T cells and treating cancer. Also provided are methods of producing the immunogenic cells.

Abstract: The present disclosure discloses an audio encoding and decoding method and an audio encoder and decoder. The audio encoding method includes: obtaining a current frame of an audio signal, where the current frame includes a high frequency band signal and a low frequency band signal; obtaining a first encoding parameter based on the high frequency band signal and the low frequency band signal; obtaining a second encoding parameter of the current frame based on the high frequency band signal, where the second encoding parameter includes tone component information; and performing bitstream multiplexing on the first encoding parameter and the second encoding parameter, to obtain an encoded bitstream.

Abstract: A display unit, a display substrate, a driving method of the display substrate and a display device are provided. The display unit includes a first electrode, a second electrode disposed above the first electrode, a functional layer disposed between the first electrode and the second electrode, and the functional layer includes a luminescent material with electrical bistable characteristics. The display unit is provided with the functional layer of the luminescent material with the electrical bistable characteristics, so that the display unit can emit light when being in a high conductivity state and still keep emitting light after being de-energized, and does not emit light when being in a low conductivity state, thereby realizing display and non-display of the display unit.

Abstract: An audio decoding method includes obtaining an encoded bitstream; performing bitstream demultiplexing on the encoded bitstream, to obtain a high frequency band parameter of a current frame of an audio signal, wherein the high frequency band parameter indicates a location, a quantity, and an amplitude or energy of a tone component comprised in a high frequency band signal of the current frame; obtaining a reconstructed high frequency band signal of the current frame based on the high frequency band parameter; and obtaining an audio output signal of the current frame based on the reconstructed high frequency band signal of the current frame.

Abstract: Disclosed is an audio coding method, including: obtaining a current frame of an audio signal, which includes a high frequency band signal and a low frequency band signal; obtaining a first encoding parameter based on the high frequency band signal and the low frequency band signal; obtaining a second encoding parameter based on the high frequency band signal, where the second encoding parameter includes tone component information of the high frequency band signal; obtaining a third encoding parameter based on the high frequency band signal, where the third encoding parameter includes sub-band envelope information of a part of a sub-band of the high frequency band signal that needs to be encoded; and performing bitstream multiplexing on the first encoding parameter, the second encoding parameter, and the third encoding parameter, to obtain an encoded bitstream.

Abstract: An audio encoding method and device and an audio decoding method and device are provided. The audio encoding method includes: obtaining a current frame of an audio signal, where the current frame includes a high frequency band signal and a low frequency band signal; obtaining a compatible layer encoding parameter of the current frame based on the high frequency band signal and the low frequency band signal; obtaining an enhancement layer encoding parameter of the current frame based on the high frequency band signal; and performing bitstream multiplexing on the compatible layer encoding parameter and the enhancement layer encoding parameter to obtain an encoded bitstream.

Abstract: A spray-capillary device is configured to process ultra-low-volume samples. The spray-capillary device includes a capillary tube that includes a lumen, an inner surface, an outer surface, an inlet end for receiving a fluid, and a discharge end having a porous section. A polymer material may be applied to the inner surface to form a polymer coating thereon. A downstream connector provides an interface between the porous section of the capillary tube, a conductive fluid, and a high voltage electrical source. The application of voltage to the downstream connector causes electrospray ionization, which can be used to draw ultra-low-volume samples into the inlet end. A gas injection assembly can be used to increase the pressure on the inlet end of the capillary tube to encourage movement of the sample therethrough. The spray-capillary device may be used to provide the ultra-low-volume samples to a mass spectrometer or other suitable analytic device.

Abstract: An antenna assembly includes a column substrate having a plurality of sides. The column substrate defines a cavity extending from a first end of the column substrate to a second end of the column substrate. The antenna assembly includes a monopole antenna disposed within the cavity. The monopole antenna is configured to communicate over a first frequency band ranging from about 5000 Megahertz to about 5900 Megahertz. The antenna assembly includes a circularly polarized antenna. The circularly polarized antenna includes a plurality of isolated magnetic dipole elements. Each of the isolated magnetic dipole elements is coupled to a different side of the column substrate. The circularly polarized antenna is configured to communicate over a second frequency band and a third frequency band. The second frequency band ranges from about 1560 Megahertz to about 1620 Megahertz. The third frequency band ranges from about 2400 Megahertz to about 2500 Megahertz.

Abstract: A method for detecting a voice activity in an input audio signal composed of frames includes that a noise characteristic of the input signal is determined based on a received frame of the input audio signal. A voice activity detection (VAD) parameter is derived based on the noise characteristic of the input audio signal using an adaptive function. The derived VAD parameter is compared with a threshold value to provide a voice activity detection decision. The input audio signal is processed according to the voice activity detection decision.

Abstract: A method for treating fluorine-containing rare earth mineral particles may include mixing a first batch of the fluorine-containing rare earth mineral particles with a first sulfuric acid solution in a weight ratio in the range of 2-10:1 of the sulfuric acid in the first sulfuric acid solution to the first batch of fluorine-containing rare earth mineral particles, and heating the mixture to cause a liquid-solid reaction. The solid phase and liquid phase may be separated after the reaction to obtain an acid filtrate and an acid residue. The acid residue may be leached with water to obtain an aqueous leaching liquor that comprises a rare earth sulfate and an aqueous leaching residue. A second sulfuric acid solution may be added to the acid filtrate in an amount such that the sulfuric acid concentration of the acid filtrate is 40-85 wt %.

Abstract: A method and an apparatus for issuing a smart contract are provided. The method may include: acquiring the smart contract; determining whether the smart contract comprises a preset function; generating, in response to determining that the smart contract does not include the preset function, verification data of the smart contract based on a proof-of-work technology; and sending a request for issuing the smart contract re based n the verification data.

Abstract: Disclosed are a method for manufacturing a coil, a coil, and an electronic device. The method includes: bonding a first side of a metal sheet onto a laser-transmitting substrate by an adhesive layer; cutting a coil pattern on a second side of the metal sheet by the laser to form a coil running through the two sides of the metal sheet on the metal sheet; bonding the second side of the metal sheet onto an adhesive tape; transmitting the laser through the laser-transmitting substrate to act on the adhesive layer to detach the laser-transmitting substrate and the adhesive layer from the first side of the metal sheet; exposing the coil pattern on the first side of the metal sheet; and forming an encapsulation layer on the coil to encapsulate the first side of the coil.

Abstract: A method for detecting an audio signal and an apparatus, where the method includes determining a segmental signal-to-noise ratio (SSNR) of an audio signal in response to the audio signal being an unvoiced signal, reducing a reference voice activity detection (VAD) decision threshold to obtain a reduced VAD decision threshold, and comparing the SSNR with the reduced VAD decision threshold to determine whether the audio signal is an active signal.

Abstract: An electronic paper is provided. An array substrate in the electronic paper includes a base, as well as a pixel electrode, a thin film transistor, and a shielding electrode that are disposed on the base. An orthographic projection of an active layer in the thin film transistor on the base is within an orthographic projection of the shielding electrode on the base and is within an orthographic projection of the pixel electrode on the base.

Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of tissue lesions. The inventors showed that CCR2 is expressed on FMCs, especially on a subpopulation of progenitor cells, that they call “fetal myeloid progenitor cells” (FMPCs), and mediates the recruitment of these cells to maternal wound tissue. Moreover, the inventors reported that recruited FMCs/FMPCs improve maternal skin wound healing by organizing blood vessel endothelium and secreting pro-angiogenesis peptides, particularly chemokine CXCL1, to enhance angiogenesis in wound. In particular, the present invention relates to CCR2 agonists for use in the treatment of tissue lesions in a subject in need thereof.

Abstract: Provided is a switchable Correlated Color Temperature (CCT) illuminating device. The device may include a CCT switching unit, forming electrical connection with a drive power source, and a bulb shell, at least one filament being arranged inside the bulb shell, the filament including a substrate, and a first light-emitting unit group and a second light-emitting unit group arranged on the substrate and forming electrical connection with the CCT switching unit. Each of the first light-emitting unit group and the second light-emitting unit group comprises one or more light-emitting unit, the first light-emitting unit group and the second light-emitting unit group are connected in parallel and conducting directions thereof are opposite, and when one of the first light-emitting unit group and the second light-emitting unit group is in a positive ON status, the other is in a negative OFF status.

Abstract: A point cloud data fusion method includes: point cloud data collected respectively by a primary radar and each secondary radar arranged on a target vehicle is acquired, where the primary radar is one of radars on the target vehicle, and the secondary radar is a radar other than the primary radar among the radars on the target vehicle; a reflectivity in the point cloud data collected by the secondary radar is adjusted based on a pre-determined reflectivity calibration table of the secondary radar to obtain adjusted point cloud data of the secondary radar, where the reflectivity calibration table represents target reflectivity information of the primary radar, which matches each reflectivity corresponding to each scanning line of the secondary radar; and the point cloud data collected by the primary radar and the adjusted point cloud data corresponding to the secondary radar are fused to obtain fused point cloud data.