Abstract: Described are methods and compositions for increasing islet-1 (Isl1) activity (e.g., biological activity) and or expression (e.g., transcription and/or translation) in a biological cell and or in a subject.

Abstract: A chimeric molecule of one or more proteins or peptides fused, complexed or linked to one or more anionic molecules. Efficient in vitro and in vivo delivery is attained by encapsulating these molecules in cationic lipids or cationic liposomes. Methods of treatment include the intracellular delivery of these molecules to a specific therapeutic target.

Abstract: A method includes aligning a first electrical connector of a first package component to a second electrical connector of a second package component. With the first electrical connector aligned to the second electrical connector, a metal layer is plated on the first and the second electrical connectors. The metal layer bonds the first electrical connector to the second electrical connector.

Abstract: One aspect of the present disclosure relates to a method of sentiment analysis based on ambiguity analysis, which includes analyzing information with the sentiment analysis models and the ambiguity analysis models. Another aspect of the present disclosure relates to a method of training the sentiment analysis models and ambiguity analysis models, which includes acquiring information, constructing lexicons, conducting sentiment analysis and ambiguity analysis with said lexicons, acquiring corpus, and training models, etc. Meanwhile, another aspect of the present disclosure relates to a system of sentiment analysis, which includes input, and output modules, acquisition modules, processing modules and database.

Abstract: A method includes aligning a first electrical connector of a first package component to a second electrical connector of a second package component. With the first electrical connector aligned to the second electrical connector, a metal layer is plated on the first and the second electrical connectors. The metal layer bonds the first electrical connector to the second electrical connector.

Abstract: In an example embodiment, an analysis application is used to optimize sensor placement by minimizing information entropy or maximizing total modal energy. These objectives are achieved by implementing a two-part optimization procedure, involving generating an evaluation database that stores an information matrix, and using the evaluation in conjunction with a genetic algorithm to produce an optimized sensor location set.

Abstract: One aspect of the present disclosure relates to a method of sentiment analysis based on ambiguity analysis, which includes analyzing information with the sentiment analysis models and the ambiguity analysis models. Another aspect of the present disclosure relates to a method of training the sentiment analysis models and ambiguity analysis models, which includes acquiring information, constructing lexicons, conducting sentiment analysis and ambiguity analysis with said lexicons, acquiring corpus, and training models, etc. Meanwhile, another aspect of the present disclosure relates to a system of sentiment analysis, which includes input, and output modules, acquisition modules, processing modules and database.

Abstract: A system and method for query selection are provided. The method may include acquiring a natural language sentence, pre-processing to obtain a standard node sequence, constructing a node tree based on the relationship between an index node and other nodes, generating a data query command based on the node tree, querying data using the data query command, and filtering the results. The standard node sequence may include at least an index node and a condition node. The node tree may be used to characterize the index-condition combination. The system may include an acquisition unit, a pre-processing unit, a node tree construction unit, a translation unit, and a querying and filtering unit.

Abstract: Compositions for the prevention, treatment and/or reversal of hearing loss include vectors encoding an Islet-1 (Isl1) nucleic acid sequence. The over-expression of Isl1 molecules in ear cells, for example, hair cells, results in the treatment of hearing loss due to age, noise exposure or any idiopathic causes.

Abstract: A toner cartridge includes a cylinder having an opening and accommodating carbon powder, a transmission member having a pipe portion sleeved onto the cylinder, an end portion and at least one outlet communicating with the opening, a powder guiding member having a main body disposed at the end portion and blades extended from the main body radially, a powder storing cover having a cover body sleeved onto the pipe portion, a powder exiting passage located under the powder guiding member and a powder exit provided on the bottom side of the cover body and communicating with the powder exiting passage, and a spring. As a result, when the blades stir the spring, the carbon powder accumulating in the powder exiting passage can be vibrated, so the carbon powder remaining near the powder exit can be effectively reduced and the powder exit can be prevented from being blocked.

Abstract: Compositions are described for direct protein delivery into multiple cell types in the mammalian inner ear. The compositions are used to deliver protein(s) (such as gene editing factors) editing of genetic mutations associated with deafness or associated disorders thereof. The delivery of genome editing proteins for gene editing and correction of genetic mutations protect or restore hearing from genetic deafness. Methods of treatment include the intracellular delivery of these molecules to a specific therapeutic target.

Abstract: A system and method for query selection are provided. The method may include acquiring a natural language sentence, pre-processing to obtain a standard node sequence, constructing a node tree based on the relationship between an index node and other nodes, generating a data query command based on the node tree, querying data using the data query command, and filtering the results. The standard node sequence may include at least an index node and a condition node. The node tree may be used to characterize the index-condition combination. The system may include an acquisition unit, a pre-processing unit, a node tree construction unit, a translation unit, and a querying and filtering unit.

Abstract: In one example embodiment, an analysis application is used to optimize water quality sensor placement in a water distribution network by implementing a two-part optimization solution procedure, involving building an impact database, and determining an optimized water quality sensor location set using the impact database. The optimized sensor location set may indicate locations that maximize a length of pipes where water quality variations are detectable by at least one water quality sensor. Pipe wall reaction coefficients may be used as calibration parameters, with water quality indicated to be detectable at a possible sensor location when a change in its pipe wall reaction coefficients leads to a change in water quality at the possible sensor location that is greater than a threshold.

Abstract: A portable and reusable installation platform for easing the installation or maintenance of an air conditioner on a vertical wall includes at least one support base upon which at least part of the air conditioner is positioned during the installation or maintenance thereof. At least one connector extends from the first end of the support base and is configured to releaseably engage the wall. At least one support leg extends downwardly from the support base and is configured to abut the wall to support the weight of the air conditioner placed upon the support base.

Abstract: In one embodiment, a technique is provided for optimizing selection of hydrants for flow test in a water distribution system. An impact database is built that indicates whether a flow test at each hydrant in the water distribution system has an impact on each pipe of the water distribution system. When a user supplies a number of hydrants to be subject to flow test, a hydrant selection solver application may search for an optimized set of hydrants for flow test that includes the user-supplied number, the searching to include generating candidate sets of hydrants and evaluating the candidate sets of hydrants based on fitness values calculated using the impact database, each fitness value to evaluate performance of a candidate set of hydrants based on flow velocity or hydraulic gradient change in pipes.

Abstract: One aspect of the present disclosure relates to a method of sentiment analysis based on ambiguity analysis, which includes analyzing information with the sentiment analysis models and the ambiguity analysis models. Another aspect of the present disclosure relates to a method of training the sentiment analysis models and ambiguity analysis models, which includes acquiring information, constructing lexicons, conducting sentiment analysis and ambiguity analysis with said lexicons, acquiring corpus, and training models, etc. Meanwhile, another aspect of the present disclosure relates to a system of sentiment analysis, which includes input, and output modules, acquisition modules, processing modules and database.

Abstract: A toner cartridge, which is adapted to be removably disposed in an electronic imaging device having a driving gear and at least one supporting member, includes an accommodating part, a gear ring, at least one rolling path portion, and a sensing protrusion. The accommodating part has an opening. The gear ring is provided on the periphery of the accommodating part for being engaged with the driving gear. The rolling path portion is provided on the periphery of the accommodating part and arc-shaped for being abutted on the supporting member in a point-contact manner. The sensing protrusion is provided on the periphery of the accommodating part and located between two ends of the rolling path portion. As a result, the toner cartridge can be positioned positively and prevented from deflection during rotation.

Abstract: In an example embodiment, a dynamic feature extraction tool receives a data set from a SHM system that includes a plurality of sensors affixed to a structure (e.g., a bridge, dam, building, etc.), the data set including at least one of ambient vibration data or earthquake vibration data. A solution method is selected from among, for example, time domain analysis, frequency domain decomposition or eigensystem realization analysis. The dynamic feature extraction tool guides a user to select at least one parameter value used in the selected solution method from a subset of determined-effective parameter values computed by the software tool. The dynamic feature extraction tool then automatically performs the selected solution method on the data set using the selected at least one parameter value to determine dynamic features (e.g., frequencies or modal shapes), and displays a graphical representation of the dynamic features in a UI.

Abstract: A toner cartridge includes a cylinder having an opening and accommodating carbon powder, a transmission member having a pipe portion sleeved onto the cylinder, an end portion and at least one outlet communicating with the opening, a powder guiding member having a main body disposed at the end portion and blades extended from the main body radially, a powder storing cover having a cover body sleeved onto the pipe portion, a powder exiting passage located under the powder guiding member and a powder exit provided on the bottom side of the cover body and communicating with the powder exiting passage, and a spring. As a result, when the blades stir the spring, the carbon powder accumulating in the powder exiting passage can be vibrated, so the carbon powder remaining near the powder exit can be effectively reduced and the powder exit can be prevented from being blocked.

Abstract: In one example embodiment, an analysis application is used to optimize sensor placement by implementing a two-part optimization solution procedure, involving generating a contribution database, and determining an optimized sensor location set using the contribution database. The optimized sensor location set may indicate locations that maximize coverage of dynamic integrity, which is quantified by as a ratio of detectable damage scenarios to all damage scenarios used by the analysis application.