Abstract: The invention relates to the generation of inner ear sensory epithelial cells through the manipulation of the expression level or function of the genes and/or proteins involved in the retinoblastoma (Rb) pathway, particularly retinoblastoma family members, such as Rb1. Methods for generating inner ear sensory epithelial cells and for restoring hearing or balance in a subject, therefore, are provided. The invention further relates to cell lines of inner ear sensory epithelial cells, such as progenitor, supporting or hair cells, where the expression level or function of the retinoblastoma genes and/or retinoblastoma proteins has been manipulated. In addition to these methods, compositions of agents for use in or the cells produced by such methods provided are also included.

Abstract: The present invention relates to a wave-filtering device with an adjustable frequency bandwidth installed in an output unit of an integrated system. The wave-filtering device is used for receiving a first output signal comprising an alternating current signal and a direct current bias voltage, and comprises a direct current bias voltage detector for receiving the first output signal and obtaining a control voltage according to the direct current bias voltage. A low-pass wave filter is electrically connected to the direct current bias voltage detector and receives the control voltage so as to adjust the frequency bandwidth. The low-pass wave filter is used for receiving the first output signal and obtaining a second output signal to be the output of the wave-filtering device with adjustable frequency bandwidth. The low-pass wave filter comprises a variable resistance the value of which varies in accordance with the value of the control voltage.

Abstract: A system and method of automatically calibrating a water distribution model is provided that allows a user to design a calibration model by selecting several input parameters desired to be used for the calibration. For example, several parameters may be chosen including the pipe roughness coefficient, junction demand, and pipe and valve operational status. Trial solutions of the model calibration are generated by a genetic algorithm program. A hydraulic network solver program then simulates each trial solution. A calibration module runs a calibration evaluation program to evaluate how closely the model simulation is to the observed data. In doing so, the calibration evaluation program computes a “goodness-of-fit” value, which is the discrepancy between the observed data and the model data, for each solution. This goodness of fit value is then assigned as the “fitness” for that solution in the genetic algorithm program.

Abstract: A system and method for performing echo cancellation in a communications network including a bi-directional two-wire communication line, and a four-wire communication line having a transmit path and a receive path. The system includes a filter coupled to the receive path for reducing the echo component. The filter uses a number of filter coefficients and selectively employs either a full LMS coefficient calculation technique to compute the filter coefficients during a first period of time to achieve quick convergence, or a sign-sign LMS coefficient calculation technique to compute the filter coefficients during a second period of time to achieve improved stability and convergence. The filter uses a power estimation of the transmit path signal to direct the filter as to which coefficient calculation technique to use.

Abstract: A system which performs automatic gain control on received audio data. The system comprises an analog adjustable gain amplifier coupled to a digital gain control loop which is preferably a digital signal processor, with an A/D converter and D/A converter interposed between the amplifier and control loop. The invention thus advantageously amplifies the analog input signal before being converted into a digital signal. This results in better performance than prior art system which amplify an already converted to digital signal which may have already been clipped before the signal could be attenuated. The combined digital/analog method provides improved detection of silence to avoid amplifying background noise. The gain control loop comprises a long-term energy averager and gain calculator as well as a short-term energy averager and gain calculator which receive the digital audio output signal.

Abstract: A system which performs automatic gain control on received audio data. The system comprises an adjustable gain amplifier coupled to a gain control loop which is preferably a digital signal processor. The gain control loop comprises a zero-crossing detector which receives the audio output signal and generates a zero crossing output upon detection of a zero crossing. The gain control loop further comprises a gain adjustment scheduler which receives the zero crossing output and a gain adjustment signal. The gain adjustment scheduler advantageously adjusts the gain of the output signal in incremental steps near zero crossings so as to minimize distortion and the possibility of clipping of the input signal. The gain control loop further comprises a voice activity detector which detects substantial voice activity, wherein the automatic gain control system amplifies the audio input signal only during the substantial voice activity.

Abstract: An improved dual tone multifrequency (DTMF) or multitone signal detector which more efficiently detects DTMF signals. For each received frame, the present invention initially performs only a portion of the Goertzel DFT algorithm for each of the possible tone frequencies and then analyzes the interim accumulated energies. The DTMF detector then selects one or more frequencies from each of the tone groups which have the largest energy values, and the detector only completes calculation of the Goertzel DFT algorithm on those selected one or more frequencies. In other words, the DTMF detector discontinues calculation of the Goertzel DFT algorithm on one or more frequencies which have low accumulated interim energies. This reduces the computational requirements and provides improved performance.

Abstract: A communications device is presented which is able to detect a ring signal without the need for dedicated ring signal detection circuitry. The communications device includes a hookswitch coupled between a telephone line and a communications circuit. In an open mode of the hookswitch, an electrical resistance of at least 25 megohms exists between two switch terminals of the hookswitch, and the communications circuit is essentially disconnected from the telephone line at d.c. A capacitor positioned between the switch terminals of the hookswitch couples a.c. signals from the telephone line to the communications circuit when the hookswitch is in the open mode. A DSP of the communications circuit performs ring signal detection when the hookswitch is in the open mode using electrical power provided by a power supply. The input impedance of the communications circuit is substantially equivalent to a series combination of an inductance and a resistance.

Abstract: An improved dual tone multifrequency (DTMF) or multitone signal detector which more efficiently and reliably detects DTMF signals. The present invention performs twist computations only when the signal has become stable, thus achieving more accuracy and reliability. The DTMF detector receives a plurality of digital samples of a received signal and calculates energy values for each of the plurality of different uncorrelated frequencies. The DSP then determines maximum values of the energy values for each of the two or more frequency groups, referred to as M(1) and M(2), to detect the plurality of tones in the received signal. The DTMF detector then performs improved twist computation and thresholding. The DTMF detector first determines if the M(1) and M(2) values of the respective frame being examined have the same indices.

Abstract: An improved dual tone multifrequency (DTMF) signal detector which uses the Goertzel DFT algorithm and which utilizes variable or differing frame widths that are frequency dependent for improved detection and reduced error. The DTMF detector includes a codec receiver which receives signals from the transmission media, and a digital signal processor (DSP) coupled to the codec. The DSP receives the digital samples and preferably applies the Goertzel DFT algorithm using differing frame lengths according to the present invention. The DTMF detector utilizes a different frame width for different tones of the possible tone frequencies according to the present invention. Thus the calculation uses a different frame length N for different ones of the uncorrelated frequencies, wherein the different frame lengths comprise at least a subset N of the number of digital samples. The different frame lengths N are designed to optimally align the calculated frequency spectrum at each of the different uncorrelated frequencies.

Abstract: An improved dual tone multifrequency (DTMF) or multitone signal detector which uses both static and dynamic thresholding techniques to provide an increased functional dynamic range, improved speech immunity for improved detection and reduced error, and simplified signal to noise ratio control. The DTMF detector receives signals from the transmission media, calculates energy values for the different frequencies, and then determines maximum values of the energy values for each of the frequency groups, referred to as M(1) and M(2). The DTMF detector then performs both static and dynamic thresholding according to the present invention to ensure valid tone detection. The static thresholding compares each of the M(1) and M(2) values with a static threshold value to ensure that the maximum energy values have a minimum energy to warrant detection.

Abstract: A long stroke pumping unit comprising a tower mounted on a base and a counterweight-polished rod system which bestrides a top wheel mounted on the top of said tower, employs an electric motor as its prime mover. The motor rotates in a fixed direction, and through a crank mechanism the rotation of electric motor is turned into a linear reciprocating movement which is in an approximately simple harmonic fashion, and then, by means consisting of fixed pulley blocks and a travelling pulley block assembly the stroke of said reciprocating movement is multiplied and transmitted to the counterweight-polished rod system. The stroke can be easily changed by changing the effective length of the crank, also, it can be selected within a great extent by changing the number of pulleys engaged in operation.