Abstract: The present disclosure relates to compositions and methods for treating Williams syndrome (WS), herein identified as a neurodevelopmental oligodendrocyte hypomyelination-associated disease, and to compositions and methods for treatment of other neurodevelopmental myelination abnormality diseases or disorders.

Abstract: An aluminum borate whisker reinforced and toughened non-metallic matrix composite is provided, which specifically includes a non-metallic material reinforced and toughened with aluminum borate whiskers. The composite exhibits a higher bending strength and fracture toughness and a higher wear resistance. A method for preparing the composite is also provided. The method includes mixing the aluminum borate whiskers and the non-metallic material to form a mixture; and sintering the mixture by a vacuum hot press method, or molding the mixture.

Abstract: As described below, the present invention features compositions and methods for neuroprotection and/or neuroregeneration of damaged or degenerating neurons. In various embodiments, the compositions and methods of the present disclosure are used to treat a neurodegenerative disease and/or nervous system injury. The methods in various embodiments include reducing or eliminating activity or expression of a target gene(s) and/or a polypeptide(s) expressed by a target gene(s) in a neuron.

Abstract: The present invention features adeno-associated virus (AAV) vectors, compositions thereof, and methods of use thereof for transducing neurons with injured axons.

Abstract: Provided herein are compositions and methods for reducing neuroinflammation and treating neurodegenerative diseases using proteinase inhibitors. The invention also provides methods for reducing post-injury scar formation in the central nervous system.

Abstract: Methods, systems and agglomerators for recovering mixed multi-plastic and natural fiber are described. The systems, methods, and the agglomerator operate at low temperatures to avoid degradation of the plastic film. The agglomerator includes cutting discs that are adjustable.

Abstract: The present disclosure relates to compositions and methods for treating Williams syndrome (WS), herein identified as a neurodevelopmental oligodendrocyte hypomyelination-associated disease, and to compositions and methods for treatment of other neurodevelopmental myelination abnormality diseases or disorders.

Abstract: A high-current high-frequency electrical connector receptacle applicable to network data transmission includes a receptacle housing and a socket tongue. The socket tongue is inserted into the receptacle housing in a front-rear direction, and a relative position thereof is locked. The socket tongue includes an upper terminal block, a lower terminal block and an insulating plastic body. The upper terminal block and the lower terminal block are both built in and fixed into the insulating plastic body. The receptacle housing is provided with a special-shaped fool-proofing unit.

Abstract: The invention features methods and compositions that are useful for the treatment of diseases, disorders, conditions, or injuries characterized by insufficient myelination. The methods involve administering GPR17 antagonists and microglia inhibitors or ablation agents.

Abstract: Disclosed herein are methods for promoting neuronal outgrowth in a subject with a neuronal lesion in their CNS by administering effective amounts of a pro-regenerative OPN fragment, optionally with IGF1 and/or BDNF. A voltage gated potassium channel blocker can also be administered. Pharmaceutical compositions, devices for administration, and kits are also disclosed.

Abstract: A battery State of Health estimation method based on a standard sample and a dual-embedded decoupling includes the steps of extracting significant characteristic peaks of the standard sample, mechanism parameter calibration of the standard sample, and on-line State of Health estimation of the test battery. The battery State of Health estimation method expounds the dual coupling relationship between temperature and aging on the characteristic peak voltage of Incremental Capacity curve from the perspective of impedance characteristic mechanism analysis, and proposes a method eliminating the voltage deviation caused by the most temperature-sensitive charge transfer resistance based on the “standard sample” to realize the decoupling of the first layer.

Abstract: A high-current high-frequency electrical connector receptacle applicable to network data transmission includes a receptacle housing and a socket tongue. The socket tongue is inserted into the receptacle housing in a front-rear direction, and a relative position thereof is locked. The socket tongue includes an upper terminal block, a lower terminal block and an insulating plastic body. The upper terminal block and the lower terminal block are both built in and fixed into the insulating plastic body. The receptacle housing is provided with a special-shaped fool-proofing unit.

Abstract: A high-current high-frequency electrical connector plug applicable to network data transmission includes a plug housing and a bayonet socket integrated in an inserted manner. The bayonet socket includes an upper terminal block, a lower terminal block and an insulating plastic body. An insertion cavity for placing a socket tongue of an electrical connector receptacle is formed in the insulating plastic body. The upper terminal block and the lower terminal block are inserted and fixed into the insertion cavity respectively. The periphery of the plug housing is sequentially provided with a left rounded part, a right rounded part, a left chamfered part and a right chamfered part. Specific sizes of the left rounded part and the right rounded part need to be controlled.

Abstract: Disclosed are compositions and methods for promoting survival of or axon regeneration in neurons by increasing mitochondrial motility in the neuron. Also disclosed are methods to treat neuronal injury and disease and disorders characterized by neuronal injury. Agents that increase Armcx1 activity, such as Armcx1 polypeptide or vectors comprising nucleic acid encoding Armcx1 polypeptide, are proposed for use in the methods. Pharmaceutical composition comprising the agents, and methods for identifying additional agents are also disclosed.

Abstract: A battery State of Health estimation method based on a standard sample and a dual-embedded decoupling includes the steps of extracting significant characteristic peaks of the standard sample, mechanism parameter calibration of the standard sample, and on-line State of Health estimation of the test battery. The battery State of Health estimation method expounds the dual coupling relationship between temperature and aging on the characteristic peak voltage of Incremental Capacity curve from the perspective of impedance characteristic mechanism analysis, and proposes a method eliminating the voltage deviation caused by the most temperature-sensitive charge transfer resistance based on the “standard sample” to realize the decoupling of the first layer.

Abstract: Methods, systems and agglomerators for recovering mixed multi-plastic and natural fiber are described. The systems, methods, and the agglomerator operate at low temperatures to avoid degradation of the plastic film. The agglomerator includes cutting discs that are adjustable.

Abstract: Described herein are methods and compositions for treating a spinal injury. Aspects of the invention relate to administering to a subject an agent that upmodulates KCC2. Another aspect of the invention relates to administering to a subject an agent that that reduces excitability of inhibitory interneurons. Compositions comprising these agents are additionally described herein.

Abstract: Disclosed herein is a method of promoting sustained survival, sustained regeneration, in a lesioned mature neuron, sustained compensatory outgrowth in a neuron, or combinations thereof. The method comprises contacting the lesioned mature neuron with an effective amount of an inhibitor of PTEN and an effective amount of an inhibitor of SOCS3 to thereby promote survival and/or regeneration and/or compensatory outgrowth of the neuron. Therapeutic methods of treatment of a subject with a neuronal lesion by administration of a therapeutically effective amount of an inhibitor of PTEN and a therapeutically effective amount of an inhibitor of SOCS3, are also disclosed, as are pharmaceutical compositions and devices for use in the methods.

Abstract: Disclosed is a floating female socket with a self-return function, which includes a female socket insulator, a female socket cover, a female socket terminal, a shielding housing, and an elastic guide plate. Two elastic guide plates are disposed, which are formed by upwardly extending left and right side walls of the shielding housing. The elastic guide plates each include an elastic side top and an arc-shaped guide part, where the elastic side top is configured to jack up against the female socket cover and is formed by inwardly extending an inner wall of the elastic guide plate. The arc-shaped guide part is formed by externally bending and extending a free end of the elastic guide plate.

Abstract: Disclosed is a floating female socket with a self-return function, which includes a female socket insulator, a female socket cover, a female socket terminal, a shielding housing, and an elastic guide plate. Two elastic guide plates are disposed, which are formed by upwardly extending left and right side walls of the shielding housing. The elastic guide plates each include an elastic side top and an arc-shaped guide part, where the elastic side top is configured to jack up against the female socket cover and is formed by inwardly extending an inner wall of the elastic guide plate. The arc-shaped guide part is formed by externally bending and extending a free end of the elastic guide plate.