Abstract: Provided are establishment and suspension acclimation of a Crandell Reese Feline Kidney (CRFK) adherent cell line, and its application. The CRFK cell line, named CRFK-BLA, is deposited at the China General Microbiological Culture Collection Center (CGMCC), with the address being Institute of Microbiology, Chinese Academy of Sciences, No. 3, Yard No. 1, Beichen West Road, Chaoyang District, Beijing, the deposit number being CGMCC NO: 45703; the CRFK cell line was classified and named CRFK cells, and was deposited on Aug. 17, 2023. A serum-free complete suspension culture type CRFK cell line obtained by acclimation on the basis of CRFK-BLA is named CRFK-BLS, and is deposited at the China General Microbiological Culture Collection Center (CGMCC), with the address being Institute of Microbiology, Chinese Academy of Sciences, No. 3, Yard No. 1, Beichen West Road, Chaoyang District, Beijing, the deposit number being CGMCC NO: 45704; the CRFK cell line was classified and named CRFK suspension cells.

Abstract: Provided are establishment and suspension acclimation of a Crandell Reese Feline Kidney (CRFK) adherent cell line, and its application. The CRFK cell line, named CRFK-BLA, is deposited at the China General Microbiological Culture Collection Center (CGMCC), with the address being Institute of Microbiology, Chinese Academy of Sciences, No. 3, Yard No. 1, Beichen West Road, Chaoyang District, Beijing, the deposit number being CGMCC NO: 45703; the CRFK cell line was classified and named CRFK cells, and was deposited on Aug. 17, 2023. A serum-free complete suspension culture type CRFK cell line obtained by acclimation on the basis of CRFK-BLA is named CRFK-BLS, and is deposited at the China General Microbiological Culture Collection Center (CGMCC), with the address being Institute of Microbiology, Chinese Academy of Sciences, No. 3, Yard No. 1, Beichen West Road, Chaoyang District, Beijing, the deposit number being CGMCC NO: 45704; the CRFK cell line was classified and named CRFK suspension cells.

Abstract: Provided is a driving device for detecting mechanical characteristics and electrical characteristics of cells. A structure of the driving device includes a piezoelectric stack, a bridge-type flexible hinge mechanism, a parallel hinge mechanism, a lead screw guide rail, a stepping motor, a linear displacement sensor, a force sensor, a ceramic needle, a first electrode, a second electrode, a cell container, an XY axis displacement platform, a positioning hole, a first metal base, a second metal base, a first metal connecting plate, a second metal connecting plate, a first pre-tightening wedge, a second pre-tightening wedge, screws, and a pre-tightening screw. During the operation of the driving device, the piezoelectric stack is driven under an excitation effect of a driving electric field signal, such that the bridge-type flexible hinge mechanism stretches, and the ceramic needle is driven by the parallel flexible hinge mechanism to move downwards.

Abstract: The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, X, Y, and HET are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Abstract: The present disclosure belongs to the field of radio frequency circuit design, and in particular relates to a M×N millimeter wave and terahertz planar dipole end-fire array antenna. The M×N millimeter wave and terahertz planar dipole end-fire array antenna is composed of M paths of N× end-fire linear array antennas arranged at equal intervals, and the distance d between two adjacent N× end-fire linear array antennas is less than ?, where ? is the wavelength, and both M and N are integers greater than 1. By connecting linear type feed networks of the M paths of N× end-fire linear array antennas to M-path in-phase radio frequency signal transmitter and controlling the distance between two adjacent N× end-fire linear array antennas to be less than the effective wavelength, a higher gain and a higher half-power width can be realized, and the power consumption of the transmitter can be reduced.

Abstract: A method and an apparatus for controlling cruise of an unmanned air vehicle based on a prefabricated construction platform, a terminal device, and a computer readable storage medium are provided. The control method comprises: acquiring personnel information at the construction site; adjusting a cruise cycle of the unmanned air vehicle based on the personnel information; transmitting the imagery data of the construction site collected by the unmanned air vehicle to the prefabricated construction platform; and completing three-dimensional modeling on the prefabricated construction platform based on the imagery data, and displaying a resulting model. In this way, the technical problem that the existing cruise method of the unmanned air vehicle has a low level of intelligence is solved.

Abstract: The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, X, Y, and HET are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Abstract: Disclosed in the present application is a high-strength seamless steel tube resistant to carbon dioxide corrosion. In addition to containing Fe and inevitable impurities, the seamless steel tube comprises the following chemical elements in mass percentage: C: 0.05-0.18%, Si: 0.15-0.40%, Mn: 0.25-0.50%, Cr: 4.0-6.0%, Mo: 0.08-0.35%, Al: 0.020-0.055%, Ca: 0.001-0.004%; and one or more elements selected from Ti, Nb, V, Ce, and La, wherein 0.003%?Ti+Nb+V+Ce+La?0.20%. Also disclosed in the present application is a manufacturing method for the seamless steel tube. The method comprises the following steps: (1) manufacturing a tube billet; (2) subjecting the tube billet to heating, perforating, hot rolling, and sizing to obtain a hot-rolled tube; and (3) subjecting the hot-rolled tube to a quenching and tempering heat treatment: quenching within a temperature range of 860-940° C. for 15-120 min, and then tempering within a temperature range of 520-620° C. for 30-150 min.

Abstract: The present disclosure provides a bainite geological drilling pipe, comprising the following chemical elements in percentage by mass: 0.14-0.22% of C, 0.2-0.55% of Si, 2.1-2.9% of Mn, 0.01-0.04% of Nb, 0.015-0.04% of Al, 0.001-0.005% of B, 0<N?0.007%, with the balance being Fe and inevitable impurities, wherein a content ratio of Al to N is Al/N?3. In addition, the present disclosure further provides a manufacturing method for the bainite geological drilling pipe, comprising the following steps: (1) performing smelting and casting on molten steel to obtain a pipe blank; (2) performing heating, piercing, continuous rolling and sizing on the pipe blank to obtain a pipe body; and (3) performing two-stage air cooling on the pipe body; in first-stage air cooling, performing air circular blowing cooling on the outer surface of the pipe body, the temperature before cooling is greater than or equal to Ar/3+50° C., the cooling rate is 5-15° C./s, and cooling to a temperature range from Bs-100° C. to Bs-50° C.

Abstract: The present disclosure provides a bainite geological drilling pipe, comprising the following chemical elements in percentage by mass: 0.14-0.22% of C, 0.2-0.55% of Si, 2.1-2.9% of Mn, 0.01-0.04% of Nb, 0.015-0.04% of Al, 0.001-0.005% of B, 0<N?0.007%, with the balance being Fe and inevitable impurities, wherein a content ratio of Al to N is Al/N?3. In addition, the present disclosure further provides a manufacturing method for the bainite geological drilling pipe, comprising the following steps: (1) performing smelting and casting on molten steel to obtain a pipe blank; (2) performing heating, piercing, continuous rolling and sizing on the pipe blank to obtain a pipe body; and (3) performing two-stage air cooling on the pipe body; in first-stage air cooling, performing air circular blowing cooling on the outer surface of the pipe body, the temperature before cooling is greater than or equal to Ar/3+50° C., the cooling rate is 5-15° C./s, and cooling to a temperature range from Bs-100° C. to Bs-50° C.

Abstract: The present invention relates to malate salt of a multi-tyrosine kinase inhibitor. In particular, the present invention relates to crystalline forms of the malate salt of multi-tyrosine kinase inhibitor N-(3-fluoro-4-((2-(5-(((2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (S)-2-hydroxysuccinate (1:1), pharmaceutical compositions comprising the crystalline form, processes for preparing the crystalline form and methods of use therefore.

Abstract: An anti-collapse oil casing with high strength and a manufacturing method therefor, comprising the following chemical elements in percentage by mass: C:0.08%-0.18%; Si:0.1%-0.4%; Mn:0.1%-0.28%; Cr:0.2%-0.8%; Mo:0.2%-0.6%; Nb:0.02%-0.08% b; V:0.01%-0.15%; Ti:0.02%-0.05%; B:0.0015%-0.005%; and Al:0.01%-0.05%. The manufacturing method for the anti-collapse oil casing with high strength comprises the steps of: (1) smelting and continuous casting; (2) perforating, rolling, and sizing; (3) controlled cooling: the initial cooling temperature being Ar3+50° C. and the final cooling temperature being ?80° C.; the cooling step being performed only to the outer surface of the casing without performing to the inner wall of the casing; and the rate of the controlled cooling being 30-70° C./s; (4) tempering; and (5) thermal straightening.

Abstract: An aqueous coating composition comprising (a) from 12.5% to 87% by weight based on the weight of the aqueous coating composition, of a film-forming polymer; (b) from 9.5% to 85% by weight based on the weight of the film-forming polymer, of a specific oligomer; and (c) from 2.5% to 50% by weight based on the weight of the film-forming polymer, of beads with a mean particle size of from 5.0 to 10.5 ?m; and a process for preparing the aqueous coating composition.

Abstract: The present disclosure belongs to the field of radio frequency circuit design, and in particular relates to a M×N millimeter wave and terahertz planar dipole end-fire array antenna. The M×N millimeter wave and terahertz planar dipole end-fire array antenna is composed of M paths of N× end-fire linear array antennas arranged at equal intervals, and the distance d between two adjacent N× end-fire linear array antennas is less than ?, where ? is the wavelength, and both M and N are integers greater than 1. By connecting linear type feed networks of the M paths of N× end-fire linear array antennas to M-path in-phase radio frequency signal transmitter and controlling the distance between two adjacent N× end-fire linear array antennas to be less than the effective wavelength, a higher gain and a higher half-power width can be realized, and the power consumption of the transmitter can be reduced.

Abstract: Disclosed is a high strength, high-temperature corrosion resistant martensitic stainless steel characterized by comprising the following chemical elements in percentages by mass: 0<C?0.05%, 0.1-0.2% of Si, 0.20-1.0% of Mn, 11.0-14.0% of Cr, 4.0-6.0% of Ni, 1.5-2.5% of Mo, 0.001%-0.10% of N, 0.03-0.2% of V, 0.01-0.1% of Nb, 0.01-0.04% of Al, and the balance being Fe and inevitable impurities. In addition, also disclosed are tubing and casing manufactured from the above-mentioned high strength, high-temperature corrosion resistant martensitic stainless steel, and a method for manufacturing the tubing and the casing. The high strength, high-temperature corrosion resistant martensitic stainless steel of the present disclosure has an excellent high temperature corrosion resistance to carbon dioxide and chloride ions, as well as excellent low-temperature impact toughness and a high-temperature strength degradation resistance.

Abstract: The present disclosure provides a low temperature resistant oil casing having high strength and high toughness, and the manufacturing method thereof, the chemical composition of the oil casing by mass of: C: 0.08-0.14%, Si: 0.1-0.4%, Mn: 0.6-1.3%, Cr: 0.5-1.5%, Mo: 0.2-0.5%, Ni: 0.2-0.5%, Nb: 0.02-0.05%, V: 0-0.1%, Al: 0.01-0.05%, Ca: 0.0005-0.005%, and the balance being Fe and unavoidable impurities. The method of manufacturing the oil casing includes: (1) smelting and continuous casting; (2) perforating and continuous rolling; (3) heat treatment, wherein an austenitizing temperature is controlled in the range of 900-930° C., and held for 30-60 min, followed by quenching, subsequently, tempering at temperature of 480-600° C., holding the temperature for 50-80 min; (4) hot sizing.

Abstract: A high-strength and high-toughness tube for perforating gun, having a formulation of chemical elements in percentage by mass as follows: C: 0.15%-0.22%, Si: 0.1%-0.4%, Mn: 0.5%-1%, Cr: 0.3%-0.7%, Mo: 0.3%-0.7%, Nb: 0.01%-0.04%, V: 0.1%-0.2%, Ti: 0.02%-0.05%, B: 0.0015%-0.005%, Al: 0.01%-0.05%, Ca: 0.001%-0.004%, N?0.008%, and the balance of Fe and other inevitable impurities. Accordingly, further disclosed is a method for manufacturing a high-strength and high-toughness tube for perforating gun. The high-strength and high-toughness tube for perforating gun of the present invention has high strength, good toughness and uniform circumferential strength, and is suitable for application in the field of petroleum exploration and exploitation.

Abstract: The present invention relates to malate salt of a multi-tyrosine kinase inhibitor. In particular, the present invention relates to crystalline forms of the malate salt of multi-tyrosine kinase inhibitor N-(3-fluoro-4-((2-(5-(((2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (S)-2-hydroxysuccinate (1:1), pharmaceutical compositions comprising the crystalline form, processes for preparing the crystalline form and methods of use therefore.

Abstract: An aqueous dispersion comprising (i) multistage polymeric particles comprising structural units of a specific polymerizable surfactant and (ii) from zero to 5%, by weight based on the weight of the multistage polymeric particles, of a metal salt; and a coating composition comprising such aqueous dispersion and providing coating films with good tannin blocking, early block resistance and sandability properties.

Abstract: A bio-enhanced deodorization equipment includes a main body and a filler container in the main body. The filler container includes a wall and at least three perforated separator plates vertically arranged in the filler container. A plurality of spaces are formed by the at least three perforated separator plates, and a microbial filler and a carrier filler are accommodated in the spaces in an alternate manner.