Patents by Inventor Zhonghua Zhang

Zhonghua Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
    Patent number: 8829185
    Abstract: This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: September 9, 2014
    Assignee: Bayer HealthCare LLC
    Inventors: Julie A. Dixon, Steven Magnuson, Barton Phillips, Yamin Wang, Tindy Li, Kyle Parcella, Jason Newcom, Harold C. E. Kluender, Zhenqiu Hong, Brent Chandler, Zhonghua Zhang, Kristen M. Allegue, Zhen Liu
  • Soluble guanylate cyclase activators
    Patent number: 8815857
    Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: August 26, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Todd Bosanac, Angela Berry, John David Ginn, Tamara Denise Hopkins, Sabine Schlyer, Fariba Soleymanzadeh, John Westbrook, Maolin Yu, Zhonghua Zhang
  • AUTOMATIC BREAD MAKER, INGREDIENT BOX AND BREAD MAKING METHOD
    Publication number: 20140079844
    Abstract: A method of making bread uses an automatic bread maker and an ingredient box. The method includes: put the bread ingredient with flour and baking powder according to proper formula into the accommodating room of the ingredient box and packaged; then place the ingredient box faced down in the hanging rack above the baking pan inside the automatic bread maker, operate the bread maker to make the sawtooth blade of the hanging rack pierced the film of the ingredient box and the bread ingredient inside fell down into the baking pan, then water the baking pan; close the housing of the automatic bread maker and turn on the baking pan, the bread ingredient is processed with working dough of mixing, stirring and kneading; get the baking pan out, and remove the bread of baked and shaped.
    Type: Application
    Filed: September 19, 2013
    Publication date: March 20, 2014
    Applicant: TSANN KUEN (ZHANGZHOU) ENTERPRISE CO., LTD.
    Inventors: Zhonghua ZHANG, Shangqian GAO, Fudong CUI, Shihchin CHEN
  • ALKOXY PYRAZOLES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS
    Publication number: 20140073629
    Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6 and R7 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Application
    Filed: September 3, 2013
    Publication date: March 13, 2014
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Jehrod Burnett BRENNEMAN, John GINN, Michael D. LOWE, Christopher Ronald SARKO, Edward S. TASBER, Zhonghua ZHANG
  • SOLUBLE GUANYLATE CYCLASE ACTIVATORS
    Publication number: 20130203729
    Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Application
    Filed: August 9, 2012
    Publication date: August 8, 2013
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Todd BOSANAC, Angela BERRY, John David GINN, Tamara Denise HOPKINS, Sabine SCHLYER, Fariba SOLEYMANZADEH, John WESTBROOK, Maolin YU, Zhonghua ZHANG
  • Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase
    Patent number: 8338594
    Abstract: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: December 25, 2012
    Assignee: Bayer HealthCare LLC
    Inventors: Steven Magnuson, Julie Dixon, Barton Phillips, Uday Khire, Lei Wang, Zhonghua Zhang, Manoj Patel, Ellalahewage Sathyajith Kumarasinghe, Philip Wickens, Alan Olague
  • SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS
    Publication number: 20120165314
    Abstract: This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
    Type: Application
    Filed: March 7, 2012
    Publication date: June 28, 2012
    Applicant: Bayer HealthCare LLC
    Inventors: Julie Dixon, Barton Phillips, Yamin Wang, Tindy Li, Kyle Parcella, Jason Newcom, Harold C.E. Kluender, Zhenqiu Hong, Brent Chandler, Zhonghua Zhang, Steven Magnuson, Kristen M. Allegue, Zheng Liu
  • Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
    Patent number: 8143393
    Abstract: This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: March 27, 2012
    Assignee: Bayer HealthCare LLC
    Inventors: Julie A. Dixon, Barton Phillips, Furahi Achebe, Harold C. E. Kluender, Jason Newcom, Kyle Parcella, Steven Magnuson, Zhenqiu Hong, Zhonghua Zhang, Zheng Liu, Uday Khire, Lei Wang, Martin Michels, Brent Chandler, Stephen O'Connor
  • Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase
    Patent number: 8138336
    Abstract: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer.
    Type: Grant
    Filed: September 22, 2008
    Date of Patent: March 20, 2012
    Assignee: Bayer HealthCare LLC
    Inventors: Steven Magnuson, Philip Wickens, Zhonghua Zhang, Ning Qi, Xin Ma
  • Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
    Patent number: 8133995
    Abstract: This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
    Type: Grant
    Filed: November 30, 2006
    Date of Patent: March 13, 2012
    Assignee: Bayer HealthCare LLC
    Inventors: Julie Dixon, Steven Magnuson, Barton Phillips, Yamin Wang, Tandy Li, Kyle Parcella, Jason Newcom, Harold Kluender, Zhenqiu Hong, Brent Chandler, Zhonghua Zhang, Kristen Allegue, Zheng Liu
  • Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
    Patent number: 8129379
    Abstract: This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: March 6, 2012
    Assignee: Bayer HealthCare LLC
    Inventors: Julie A. Dixon, Barton Phillips, Furahi Achebe, Harold C. E. Kluender, Jason Newcom, Kyle Parcella, Steven Magnuson, Zhenqiu Hong, Zhonghua Zhang, Zheng Liu, Uday Khire, Lei Wang, Martin Michels, Brent Chandler, Stephen O'Connor
  • Indole acetic acid derivatives and their use as pharmaceutical agents
    Patent number: 7964622
    Abstract: This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic disease. The invention is also directed to intermediates useful in preparation of indole acetic derivatives and to methods of preparation.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: June 21, 2011
    Assignee: Bayer Healthcare LLC
    Inventors: Xin Ma, Louis-David Cantin, Soongyu Choi, Roger Clark, Martin Hentemann, Joachim Rudolph, Rico Lavoie, Zhonghua Zhang
  • PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING CANCER THROUGH INHIBITION OF AURORA KINASE
    Publication number: 20110021518
    Abstract: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer.
    Type: Application
    Filed: December 1, 2006
    Publication date: January 27, 2011
    Applicant: BAYER HEALTHCARE LLC.
    Inventors: Steven Magnuson, Julie Dixon, Barton Phillips, Uday Khire, Lei Wang, Zhonghua Zhang, Manoj Patel, Ellalahewage Sathyajith Kumarasinghe, Philip Wickens, Alan Olague
  • PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING CANCER THROUGH INHIBITION OF AURORA KINASE
    Publication number: 20100273800
    Abstract: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer.
    Type: Application
    Filed: September 22, 2008
    Publication date: October 28, 2010
    Inventors: Steven Magnuson, Philip Wickens, Zhonghua Zhang, Ning Qi, Xin Ma
  • SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS
    Publication number: 20100179125
    Abstract: This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: September 2, 2009
    Publication date: July 15, 2010
    Applicant: Bayer HealthCare LLC
    Inventors: Julie A. Dixon, Barton Phillips, Furahi Achebe, Harold C. E. Kluender, Jason Newcom, Kyle Parcella, Steven Magnuson, Zhenqiu Hong, Zhonghua Zhang, Zheng Liu, Uday Khire, Lei Wang, Martin Michels, Brent Chandler, Stephen O'Connor
  • Substituted 4-Amino-Pyrrolotriazine Derivatives Useful for Treating Hyper-Proliferative Disorders and Diseases Associated with Angiogenesis
    Publication number: 20100063038
    Abstract: This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: December 1, 2006
    Publication date: March 11, 2010
    Inventors: Julie Dixon, Barton Phillips, Furahi Achebe, Harold Kluender, Jason Newcom, Kyle Parcella, Stephen J. O'Connor, Steven Magnuson, Zhenqui Hong, Zhonghua Zhang, Zheng Liu, Uday Khire, Lei Wang, Martin Michels, Brent Chandler
  • Indole acetic acid derivatives and their use as pharmaceutical agents
    Publication number: 20090298854
    Abstract: This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic disease. The invention is also directed to intermediates useful in preparation of indole acetic derivatives and to methods of preparation.
    Type: Application
    Filed: July 23, 2009
    Publication date: December 3, 2009
    Inventors: Xin Ma, Louis-David Cantin, Soongyu Choi, Roger Clark, Martin Hentemann, Joachim Rudolph, Rico Lavoie, Zhonghua Zhang
  • Substituted 4-Amino-Pyrrolotriazine Derivatives Useful for Treating Hyper-Proliferative Disorders and Diseases Associated With Angiogenesis
    Publication number: 20090281079
    Abstract: This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
    Type: Application
    Filed: November 30, 2006
    Publication date: November 12, 2009
    Applicant: BAYER HEALTHCARE LLV
    Inventors: Julie Dixon, Steven Magnuson, Barton Phillips, Yamin Wang, Tandy Li, Kyle Parcella, Jason Newcom, Harold Kluender, Zhenqiu Hong, Brent Chandler, Zhonghua Zhang, Kristen Allegue, Zheng Liu
  • Indole acetic acid derivatives and their use as pharmaceutical agents
    Patent number: 7592361
    Abstract: This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic disease. The invention is also directed to intermediates useful in preparation of indole acetic derivatives and to methods of preparation.
    Type: Grant
    Filed: April 28, 2004
    Date of Patent: September 22, 2009
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Xin Ma, Louis-David Cantin, Soongyu Choi, Roger Clark, Martin Hentemann, Joachim Rudolph, Rico Lavoie, Zhonghua Zhang
  • Indole acetic acid derivatives and their use as pharmaceutical agents
    Publication number: 20060264486
    Abstract: This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic disease. The invention is also directed to intermediates useful in preparation of indole acetic derivatives and to methods of preparation.
    Type: Application
    Filed: April 28, 2004
    Publication date: November 23, 2006
    Inventors: Xin Ma, Louis-David Cantin, Soongyu Choi, Roger Clark, Martin Hentemann, Joachim Rudolph, Rico Lavoie, Zhonghua Zhang