Patents by Inventor Zhonghua Zhang

Zhonghua Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160145258
    Abstract: The present invention relates to a new crystalline forms of the inhibitor, 5-fluoro-3-phenyl-2-[(S)-1-(9H-purin-6-ylamino)-propyl]-3H-quinazoline-4-one; the new crystalline form, compared to known forms, has one or more improved properties. The present invention also relates to a method for preparing a new crystalline form of 5-fluoro-3-phenyl-2-[(S)-1-(9H-purin-6-ylamino)-propyl]-3H-quinazolin-4-one, a pharmaceutical composition thereof and a use thereof in preparation of a pharmaceutical for the treatment and/or prevention of diseases such as chronic lymphocytic leukemia and indolent non-Hodgkin's lymphoma.
    Type: Application
    Filed: December 2, 2015
    Publication date: May 26, 2016
    Applicant: Hangzhou Pushai Pharmaceutical Technology Co., LTD.
    Inventors: Zhonghua ZHANG, Xiaoxia Sheng, Xiaohong Sheng
  • Publication number: 20160024059
    Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R5, R6, R7, R8, R9, B, V, W, X, Y, Z and m are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Application
    Filed: July 21, 2015
    Publication date: January 28, 2016
    Inventors: Jehrod Burnett BRENNEMAN, John David GINN, Tamara Denise HOPKINS, MIchael D. LOWE, Christopher Ronald SARKO, John A. WESTBROOK, Maolin YU, Zhonghua ZHANG
  • Publication number: 20150321167
    Abstract: The present invention relates to a method for preparing a solid amine gas adsorption material. The method synthesizes a porous solid amine gas adsorption material that loads organic amine evenly in one step. In the method, a certain amount of acidic gas is introduced while organic amine molecules are introduced into a silicate solution as template agents, which not only makes sizes of SiO2 pore channels homogeneous, but also makes organic amine molecules highly evenly distributed on a surface of SiO2. In addition, the acidic gas protects —NH2 groups of organic amine, and avoids —NH2 adhesion inactivation due to hydrogen bonding during the synthesis process of the material. The present invention also relates to a method for preparing a solid amine gas adsorption material after obtaining a silicate solution from fly ash. The preparation methods of the present invention are simple in process and do not require special devices.
    Type: Application
    Filed: November 27, 2012
    Publication date: November 12, 2015
    Applicants: NATIONAL INSTITUTE OF CLEAN-AND-LOW-CARBON ENERGY, SHENHUA GROUP CORPORATION LIMITED
    Inventors: Baodong Wang, Zhonghua Zhang, Qi Sun
  • Publication number: 20150258531
    Abstract: A method of making a nanotube array structure includes forming a nanorod array template on a substrate, coating a nanotube material over the nanorod array template, forming a coated template, annealing the coated template, and drying the coated template. The method then includes heating the coated template to an elevated temperature, relative to ambient temperature, at a heating rate while flowing a gas mixture including a reducing gas over the substrate at a flow rate, the reducing gas reacting with the nanorod array template and forming a gaseous byproduct and the nanotube array structure in which nanotubes may be substantially aligned with adjacent nanotubes. The nanotube array structure can be used, for example, in sensor, catalyst, transistor, or solar cell applications.
    Type: Application
    Filed: September 13, 2013
    Publication date: September 17, 2015
    Inventors: Pu-Xian Gao, Zhonghua Zhang
  • Patent number: 8906904
    Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6 and R7 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: December 9, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Jehrod Burnett Brenneman, John Ginn, Michael D. Lowe, Christopher Ronald Sarko, Edward S. Tasber, Zhonghua Zhang
  • Publication number: 20140256534
    Abstract: A metal oxide nanorod array structure according to embodiments disclosed herein includes a monolithic substrate having a surface and multiple channels, an interface layer bonded to the surface of the substrate, and a metal oxide nanorod array coupled to the substrate surface via the interface layer. The metal oxide can include ceria, zinc oxide, tin oxide, alumina, zirconia, cobalt oxide, and gallium oxide. The substrate can include a glass substrate, a plastic substrate, a silicon substrate, a ceramic monolith, and a stainless steel monolith. The ceramic can include cordierite, alumina, tin oxide, and titania. The nanorod array structure can include a perovskite shell, such as a lanthanum-based transition metal oxide, or a metal oxide shell, such as ceria, zinc oxide, tin oxide, alumina, zirconia, cobalt oxide, and gallium oxide, or a coating of metal particles, such as platinum, gold, palladium, rhodium, and ruthenium, over each metal oxide nanorod.
    Type: Application
    Filed: September 28, 2012
    Publication date: September 11, 2014
    Applicant: University of Connecticut
    Inventors: Pu-Xian Gao, Yanbing Guo, Zhonghua Zhang, Zheng Ren
  • Patent number: 8829185
    Abstract: This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: September 9, 2014
    Assignee: Bayer HealthCare LLC
    Inventors: Julie A. Dixon, Steven Magnuson, Barton Phillips, Yamin Wang, Tindy Li, Kyle Parcella, Jason Newcom, Harold C. E. Kluender, Zhenqiu Hong, Brent Chandler, Zhonghua Zhang, Kristen M. Allegue, Zhen Liu
  • Patent number: 8815857
    Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: August 26, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Todd Bosanac, Angela Berry, John David Ginn, Tamara Denise Hopkins, Sabine Schlyer, Fariba Soleymanzadeh, John Westbrook, Maolin Yu, Zhonghua Zhang
  • Publication number: 20140079844
    Abstract: A method of making bread uses an automatic bread maker and an ingredient box. The method includes: put the bread ingredient with flour and baking powder according to proper formula into the accommodating room of the ingredient box and packaged; then place the ingredient box faced down in the hanging rack above the baking pan inside the automatic bread maker, operate the bread maker to make the sawtooth blade of the hanging rack pierced the film of the ingredient box and the bread ingredient inside fell down into the baking pan, then water the baking pan; close the housing of the automatic bread maker and turn on the baking pan, the bread ingredient is processed with working dough of mixing, stirring and kneading; get the baking pan out, and remove the bread of baked and shaped.
    Type: Application
    Filed: September 19, 2013
    Publication date: March 20, 2014
    Applicant: TSANN KUEN (ZHANGZHOU) ENTERPRISE CO., LTD.
    Inventors: Zhonghua ZHANG, Shangqian GAO, Fudong CUI, Shihchin CHEN
  • Publication number: 20140073629
    Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6 and R7 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Application
    Filed: September 3, 2013
    Publication date: March 13, 2014
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Jehrod Burnett BRENNEMAN, John GINN, Michael D. LOWE, Christopher Ronald SARKO, Edward S. TASBER, Zhonghua ZHANG
  • Publication number: 20130203729
    Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Application
    Filed: August 9, 2012
    Publication date: August 8, 2013
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Todd BOSANAC, Angela BERRY, John David GINN, Tamara Denise HOPKINS, Sabine SCHLYER, Fariba SOLEYMANZADEH, John WESTBROOK, Maolin YU, Zhonghua ZHANG
  • Patent number: 8338594
    Abstract: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: December 25, 2012
    Assignee: Bayer HealthCare LLC
    Inventors: Steven Magnuson, Julie Dixon, Barton Phillips, Uday Khire, Lei Wang, Zhonghua Zhang, Manoj Patel, Ellalahewage Sathyajith Kumarasinghe, Philip Wickens, Alan Olague
  • Publication number: 20120165314
    Abstract: This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
    Type: Application
    Filed: March 7, 2012
    Publication date: June 28, 2012
    Applicant: Bayer HealthCare LLC
    Inventors: Julie Dixon, Barton Phillips, Yamin Wang, Tindy Li, Kyle Parcella, Jason Newcom, Harold C.E. Kluender, Zhenqiu Hong, Brent Chandler, Zhonghua Zhang, Steven Magnuson, Kristen M. Allegue, Zheng Liu
  • Patent number: 8143393
    Abstract: This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: March 27, 2012
    Assignee: Bayer HealthCare LLC
    Inventors: Julie A. Dixon, Barton Phillips, Furahi Achebe, Harold C. E. Kluender, Jason Newcom, Kyle Parcella, Steven Magnuson, Zhenqiu Hong, Zhonghua Zhang, Zheng Liu, Uday Khire, Lei Wang, Martin Michels, Brent Chandler, Stephen O'Connor
  • Patent number: 8138336
    Abstract: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer.
    Type: Grant
    Filed: September 22, 2008
    Date of Patent: March 20, 2012
    Assignee: Bayer HealthCare LLC
    Inventors: Steven Magnuson, Philip Wickens, Zhonghua Zhang, Ning Qi, Xin Ma
  • Patent number: 8133995
    Abstract: This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
    Type: Grant
    Filed: November 30, 2006
    Date of Patent: March 13, 2012
    Assignee: Bayer HealthCare LLC
    Inventors: Julie Dixon, Steven Magnuson, Barton Phillips, Yamin Wang, Tandy Li, Kyle Parcella, Jason Newcom, Harold Kluender, Zhenqiu Hong, Brent Chandler, Zhonghua Zhang, Kristen Allegue, Zheng Liu
  • Patent number: 8129379
    Abstract: This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: March 6, 2012
    Assignee: Bayer HealthCare LLC
    Inventors: Julie A. Dixon, Barton Phillips, Furahi Achebe, Harold C. E. Kluender, Jason Newcom, Kyle Parcella, Steven Magnuson, Zhenqiu Hong, Zhonghua Zhang, Zheng Liu, Uday Khire, Lei Wang, Martin Michels, Brent Chandler, Stephen O'Connor
  • Patent number: 7964622
    Abstract: This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic disease. The invention is also directed to intermediates useful in preparation of indole acetic derivatives and to methods of preparation.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: June 21, 2011
    Assignee: Bayer Healthcare LLC
    Inventors: Xin Ma, Louis-David Cantin, Soongyu Choi, Roger Clark, Martin Hentemann, Joachim Rudolph, Rico Lavoie, Zhonghua Zhang
  • Publication number: 20110021518
    Abstract: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer.
    Type: Application
    Filed: December 1, 2006
    Publication date: January 27, 2011
    Applicant: BAYER HEALTHCARE LLC.
    Inventors: Steven Magnuson, Julie Dixon, Barton Phillips, Uday Khire, Lei Wang, Zhonghua Zhang, Manoj Patel, Ellalahewage Sathyajith Kumarasinghe, Philip Wickens, Alan Olague
  • Publication number: 20100273800
    Abstract: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer.
    Type: Application
    Filed: September 22, 2008
    Publication date: October 28, 2010
    Inventors: Steven Magnuson, Philip Wickens, Zhonghua Zhang, Ning Qi, Xin Ma