Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, wherein X, R1, R2 and R3 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Abstract: An online-control cooling process for seamless steel tube for effectively refining grains, comprising the following steps: when the temperature of a crude tube is higher than Ar3, evenly spraying water along the circumferential direction of the tube so as to continuously cool the tube to T1° C.˜T2° C., the cooling rate being controlled to be N1° C./s˜N2° C./s, wherein T1=810?360C?80(Mn+Cr)?37Ni?83Mo, T2=T1+115° C., N1=55-80×C, N2=168*(0.8?C), and C, Mn, Cr, Ni and Mo in the equations each represent the mass percentage of corresponding elements in the seamless steel tube; then, cooling to the room temperature at cooling rate no more than 10° C./s. Correspondingly, also provided are a method for manufacturing seamless steel tube for effectively refining grains, and a seamless steel tube. The online-control seamless steel tube cooling process does not require adding too many alloying elements, which is simple and can yield seamless steel tubes with good grain refinement and better toughness.

Abstract: The present invention discloses an ultra-high strength and ultra-high toughness casing steel, having a microstructure of tempered sorbite, and the content of chemical elements by mass percent thereof being as follows: C: 0.1-0.22%, Si: 0.1-0.4%, Mn: 0.5-1.5%, Cr: 1-1.5%, Mo: 1-1.5%, Nb: 0.01-0.04%, V: 0.2-0.3%, Al: 0.01-0.05%, Ca: 0.0005-0.005%, the balance being Fe and unavoidable impurities. Correspondingly, the invention also discloses a casing obtained by processing the ultra-high strength and ultra-high toughness casing steel and a manufacturing method thereof. The ultra-high strength and ultra-toughness casing steel and the casing of the present invention have a strength of 155 ksi or more and an impact toughness greater than 10% of its yield strength value, thereby realizing a combination of ultra-high strength and ultra-high toughness.

Abstract: A method for manufacturing a bainite high-strength seamless steel tube, comprising the following steps: smelting, manufacturing a billet, heating, perforating, rolling, stretch reducing or sizing to obtain tube, and cooling. In the cooling step, the quenching starting temperature is controlled to be at least 20° C. higher than the Ar3 temperature of the steel grade; the finish cooling temperature is controlled to be within a range between T1 and T2, where T1=519?423C?30.4Mn, T2=780?270C?90Mn, and the units of the T1 and the T2 are ° C.; in the formulas, C and Mn respectively represent the mass percents of element C and element Mn of the steel grade, the content of the element C is 0.06-0.2%, and the content of the element Mn is 1-2.5%; the cooling rate is controlled to be 15-80° C./s; and the finished product of the bainite high-strength seamless steel tube is directly obtained after the cooling step.

Abstract: A seamless steel tube with high strength and toughness, comprising the following chemical elements by mass: 0.1-0.25% of C, 0.1-0.5% of Si, 0.01-0.1% of Al, 0.6-2% of Mn, the balance of Fe and other unavoidable impurities, wherein C+Mn/6?0.35. Also provided is a method for preparing a seamless steel tube.

Abstract: An process for the on-line quenching of seamless steel tube using residual heat, a method for manufacturing a seamless steel tube, and a seamless steel tube. The process for the on-line quenching of a seamless steel tube comprises the following steps: when the temperature of a tube is higher than Ar3, evenly spraying water along a circumferential direction of the tube so as to continuously cool the tube to be not higher than T° C., the cooling rate being controlled to be E1° C./s to E2° C./s to obtain a microstructure with martensite as the main composition, wherein T=Ms?95° C., Ms represents the martensitic phase transition temperature, E1=20×(0.5?C)+15×(3.2?Mn)?8×Cr?28×Mo?4×Ni?2800×B, and E2=96×(0.45?C)+12×(4.6?Mn), and the C, Mn, Cr, Ni, B and Mo in the equations each represents the mass percentages of corresponding elements in the seamless steel tube.

Abstract: The invention discloses a vacuum juicer, and belongs to the field of juicers. The vacuum juicer comprises a vacuum cover assembly, a stirring cup assembly and a main unit, wherein the vacuum cover assembly comprises a vacuum cover and a cam rotating around the vacuum cover, and a sealant is arranged on the cam; the stirring cup assembly comprises a stirring cup holder and a stirring cup, and a movable valve is arranged on the stirring cup and slides up and down to control opening and closing of a stirring cup air hole; a vacuum pump in the main unit is in sealed connection with the internal space of the vacuum cover. According to the vacuum juicer, the interior of the stirring cup can be vacuumized before and during fruit juice stirring, the stirring cup can be taken out to be carried and stored in the vacuum state for a period of time, and the phenomenon that fruit juice makes contact with air and consequentially is oxidized is avoided during this period of time.

Abstract: The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, X, Y, and HET are as defined herein.

Abstract: There is disclosed an ultrahigh strength and ultrahigh toughness oil casing pipe, comprising the following chemical elements in mass percentages: C: 0.12-0.18%; Si: 0.1-0.4%; Mn: 1.1-1.6%; Cr: 0.1-0.4%; Mo: 0.2-0.5%; Nb: 0.02-0.04%; Ti: 0.02-0.05%; B: 0.0015-0.005%; Al: 0.01-0.05%; Ca: 0.0005-0.005%; N?0.008%; with the proviso of 0<(Ti—3.4N)?0.02%, Ti/B?10; and the balance of Fe and other unavoidable impurities. The strength of the oil casing pipe can be equal to or higher than 150 ksi steel grade, and the zero degree lateral Charpy impact work is not less than 10% of the yield strength of the 150 ksi steel grade.

Abstract: The present invention relates to a method for preparing a solid amine gas adsorption material. The method synthesizes a porous solid amine gas adsorption material that loads organic amine evenly. In the method, a certain amount of acidic gas is introduced while organic amine molecules are introduced into a silicate solution as template agents, which not only makes sizes of SiO2 pore channels homogeneous, but also makes organic amine molecules highly evenly distributed on a surface of SiO2. In addition, the acidic gas protects —NH2 groups of organic amine, and avoids —NH2 adhesion inactivation due to hydrogen bonding during the synthesis process of the material. The present invention also relates to a method for preparing a solid amine gas adsorption material after obtaining a silicate solution from fly ash. The solid amine gas adsorption material prepared has more stable and effective gas adsorption performance.

Abstract: A method of making bread uses an automatic bread maker and an ingredient box. The method includes: put the bread ingredient with flour and baking powder according to proper formula into the accommodating room of the ingredient box and packaged; then place the ingredient box faced down in the hanging rack above the baking pan inside the automatic bread maker, operate the bread maker to make the sawtooth blade of the hanging rack pierced the film of the ingredient box and the bread ingredient inside fell down into the baking pan, then water the baking pan; close the housing of the automatic bread maker and turn on the baking pan, the bread ingredient is processed with working dough of mixing, stirring and kneading; get the baking pan out, and remove the bread of baked and shaped.

Abstract: A method of making bread uses an automatic bread maker and an ingredient box. The method includes: put the bread ingredient with flour and baking powder according to proper formula into the accommodating room of the ingredient box and packaged; then place the ingredient box faced down in the hanging rack above the baking pan inside the automatic bread maker, operate the bread maker to make the sawtooth blade of the hanging rack pierced the film of the ingredient box and the bread ingredient inside fell down into the baking pan, then water the baking pan; close the housing of the automatic bread maker and turn on the baking pan, the bread ingredient is processed with working dough of mixing, stirring and kneading; get the baking pan out, and remove the bread of baked and shaped.

Abstract: A method of making bread uses an automatic bread maker and an ingredient box. The method includes: put the bread ingredient with flour and baking powder according to proper formula into the accommodating room of the ingredient box and packaged; then place the ingredient box faced down in the hanging rack above the baking pan inside the automatic bread maker, operate the bread maker to make the sawtooth blade of the hanging rack pierced the film of the ingredient box and the bread ingredient inside fell down into the baking pan, then water the baking pan; close the housing of the automatic bread maker and turn on the baking pan, the bread ingredient is processed with working dough of mixing, stirring and kneading; get the baking pan out, and remove the bread of baked and shaped.

Abstract: The present invention relates to new crystalline forms of the inhibitor, 5-fluoro-3-phenyl-2-[(S)-1-(9H-purin-6-ylamino)-propyl]-3H-quinazoline-4-one; the present invention also relates to methods for preparing the new crystalline forms of 5-fluoro-3-phenyl-2-[(S)-1-(9H-purin-6-ylamino)-propyl]-3H-quinazolin-4-one, pharmaceutical compositions containing the new crystalline forms thereof, and uses thereof for the treatment and/or prevention of diseases such as chronic lymphocytic leukemia and indolent non-Hodgkin's lymphoma.

Abstract: The bread maker includes a housing for mounting of a container, an infrared transceiving device and a determining device. The container stores bread ingredients therein and has an outer surface provided with a color symbol. The infrared transceiving device includes an infrared emitting unit and a processing unit. The infrared emitting unit is operable to emit infrared ray toward the color symbol when the container is mounted to the housing. The processing unit is configured for receiving a reflection ray reflected from the color symbol and is operable to output an identification signal according to intensity of the reflection ray. The determining device is communicatively connected to the processing unit for receiving the identification signal and is operable to determine, with reference to the identification signal, a bread-making indicator that is associated with a bread making program, which the bread maker executes automatically to make bread using the bread ingredients stored in the container.

Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R5, R6, R7, R8, R9, B, V, W, X, Y, Z and m are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Abstract: The present invention relates to a new crystalline forms of the inhibitor, 5-fluoro-3-phenyl-2-[(S)-1-(9H-purin-6-ylamino)-propyl]-3H-quinazoline-4-one; the new crystalline form, compared to known forms, has one or more improved properties. The present invention also relates to a method for preparing a new crystalline form of 5-fluoro-3-phenyl-2-[(S)-1-(9H-purin-6-ylamino)-propyl]-3H-quinazolin-4-one, a pharmaceutical composition thereof and a use thereof in preparation of a pharmaceutical for the treatment and/or prevention of diseases such as chronic lymphocytic leukemia and indolent non-Hodgkin's lymphoma.

Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6 and R7 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.