Quinoline carboxylic acid derivatives having 7-(4-amino-methyl-3-oxime) pyrrolidine substituent and processes for preparing thereof

- LG Electronics

The present invention relates to a novel quinolone compound having an excellent antibacterial activity. More specifically the present invention relates to a novel quinoline(naphthyridine)carboxylic acid derivative represented by the following formula (I), which has an 4-aminomethyl-3-oximepyrrolidine substituent on 7-position of the quinolone nucleus and shows a superior antibacterial activity in contrast to the known quinolone antibactrial agents having a weak activity against gram-positive bacterial strains and also has a broad antibacterial spectrum and a highly improved pharmacokinetic property ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and Q are defined as described in the specification.

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Claims

1. A compound of formula III ##STR267## or a pharmaceutically acceptable salt thereof.

Referenced Cited
Foreign Patent Documents
0541086 May 1993 EPX
1-100165 April 1989 JPX
Other references
Patent History
Patent number: 5840916
Type: Grant
Filed: Apr 4, 1997
Date of Patent: Nov 24, 1998
Assignee: LG Chemical Ltd. (Seoul)
Inventors: Chang Yong Hong (Daejeon), Young Kwan Kim (Kyungki-do), Jay Hyok Chang (Daejeon), Se Ho Kim (Seoul), Hoon Choi (Daejeon), Do Hyun Nam (Daejeon), Jin-Hwan Kwak (Daejeon), Yi Na Jeong (Daejeon), Jeong In Oh (Daejeon), Mu Yong Kim (Daejeon)
Primary Examiner: Joseph McKane
Law Firm: Banner & Witcoff, Ltd.
Application Number: 8/825,991
Classifications
Current U.S. Class: Nitrogen Attached Directly To The Five-membered Hetero Ring By Nonionic Bonding (548/557)
International Classification: C07D20722;