Patents Issued in February 20, 2001
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Patent number: 6191074Abstract: The fabrication of superconducting wires and rods having desired and consistent electrical and mechanical properties, in particular those based on Yttrium Barium Copper Oxide (YBCO) and Bismuth Strontium Calcium Copper Oxide (BSCCO), is disclosed. The first fabrication step is to form an extrudable paste by mixing YBCO or BSCCO superconducting powder with a set of organic additives, which include binder, plasticizer, lubricant, dispersant, and a solvent. The following additional steps are performed on both YBCO and BSCCO based wires or rods: (i) using a piston extruder to extrude the superconducting wire or rod; (ii) drying the wire or rod to remove the solvent; and (iii) subjecting the wire or rod to a binder burn-out treatment to remove the remaining organic additives. In addition, YBCO wires and rods also require a sintering step, while BSCCO wires and rods also require cold isostatic pressing and heat treatment steps.Type: GrantFiled: April 2, 1997Date of Patent: February 20, 2001Assignee: University of HoustonInventors: Krishnaswamy Ravi-Chandar, Devamanohar Ponnusamy, Kamel Salama
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Patent number: 6191075Abstract: A method of preparing a high temperature superconductor. A method of preparing a superconductor includes providing a powdered high temperature superconductor and a nanophase paramagnetic material. These components are combined to form a solid compacted mass with the paramagnetic material disposed on the grain boundaries of the polycrystaline high temperature superconductor.Type: GrantFiled: December 21, 1993Date of Patent: February 20, 2001Assignee: University of ChicagoInventors: Uthamalingam Balachandran, Richard W. Siegel, Thomas R. Askew
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Patent number: 6191076Abstract: An esterification process and the products resulting from it which achieves a mixture of secondary esters which are effectively used with invert drilling muds, the process involving the addition of one or more C1-C5 carboxylic acids and one or more C3-C22 olefins in the presence of an acid catalyst.Type: GrantFiled: February 9, 1999Date of Patent: February 20, 2001Assignee: Chevron Phillips Chemical Company LCInventor: Jeffery C. Gee
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Patent number: 6191077Abstract: A method of cleaning mineral-oil-based liquid cooling lubricants in which the cooling lubricants, which are continuously circulated in metal-working plants, are cleaned by a deposition filtration system. A continuous or discontinuous inoculation or introduction of filtering aid material is carried out in the filtration circuit during the filtration of the liquid cooling lubricant.Type: GrantFiled: December 23, 1999Date of Patent: February 20, 2001Assignees: Bayerische Motoren Werke Aktiengesellschaft, Filterwerk Mann & Hummel GmbHInventors: Reinhard Baumgartner, Karl-Guenther Bremer, Rudi Bungenberg, Walter Janning, Joachim Panhans, Eduard Rauscher
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Patent number: 6191078Abstract: An aviation piston engine lubricant having no metal containing additive is provided. The lubricant contains (a) a base oil consisting essentially of a mixture of (i) at least about 50 wt % based on the total weight of the lubricant of one or more mineral oils having a viscosity in the range of about 5 cSt to about 25 cSt at 100° C. and (ii) about 15 to about 40 wt % based on the total weight of the lubricant of a polyalpha olefin fluid having a viscosity in the range of about 4 cSt to about 40 cSt at 100° C.; (b) at least about 3 wt % based on the total weight of the lubricant of an ashless polyisobutylene succinic anhydride/polyamine (PIBSA/PAM) dispersant; and (c) an effective amount of one or more ashless additives selected from the group consisting of antiwear agents, extreme pressure agents, metal passivators, and antioxidants.Type: GrantFiled: September 21, 1999Date of Patent: February 20, 2001Assignee: ExxonMobil Research and Engineering CompanyInventors: Antika Shlomo, Frederick W. Girshick, Patrick Edward Godici, Richard A. Skillman
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Patent number: 6191079Abstract: A lubricant additive suitable for combination with an aqueous-based paper or paper board coating mixture wherein the lubricant additive is selected from the group consisting of a polyoxyalkylene mono- and di-ester of phosphoric acid, a polyoxyalkylene mono- and di-ester of a phosphoric acid salt, and a mixture thereof.Type: GrantFiled: March 2, 1994Date of Patent: February 20, 2001Assignee: GEO Specialty Chemicals, Inc.Inventors: Rudolph Klima, John Krasniewski, Jose Maria Rodriguez
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Patent number: 6191080Abstract: A heat resistant lubricating oil composition which exhibits high heat resistance and oxidation resistance under high temperature conditions, and can withstand severe working conditions, as in jet engines or gas turbines. The lubricating oil composition comprises a polyphenylthioether of formula {I} in a lubricating base oil, comprising any one of a polyol ester, dibasic acid ester, a polyphenyl ether, an organopolysiloxane and admixtures thereof.Type: GrantFiled: February 14, 1997Date of Patent: February 20, 2001Assignee: Tonen CorporationInventors: Hiroshi Nakanishi, Ko Onodera, Makoto Kanbara, Atsuhisa Kobori, Yoshinobu Nakamura
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Patent number: 6191081Abstract: A long life lubricating oil as evidenced by a reduction in viscosity increase, oxidation and nitration, comprises a major amount of a base oil of lubricating viscosity and a minor amount of a mixture of high TBN, medium TBN and low/neutral TBN detergents wherein metal salicylate detergent is at least one of the medium or low/neutral TBN detergents.Type: GrantFiled: December 15, 1999Date of Patent: February 20, 2001Assignee: ExxonMobil Research and Engineering CompanyInventors: Stanley James Cartwright, James Walter Finch
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Patent number: 6191082Abstract: A lubricating oil for a flon refrigerant, containing a polyglycol compound having a kinematic viscosity at 40° C. of at least 30 cSt, a viscosity index of at least 150 and a water content of not more than 200 ppm as a main component. The lubricating oil of the present invention has good stability in the presence of a flon refrigerant, does not cause the copper plating phenomenon and has good compatibility with not only flon-11 and flon-12 but also sparingly soluble refrigerants such as hydrogen-containing flon compounds and perfluoroalkane.Type: GrantFiled: May 25, 2000Date of Patent: February 20, 2001Assignee: Idemitsu Kosan Co., Ltd.Inventor: Masato Kaneko
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Patent number: 6191083Abstract: Personal cleansing compositions comprise a thickening system consisting essentially of associative polymer which is a hydrophobically modified water-soluble associative polymer and polar oil having a required HLB of at least 12, a water-soluble surfactant, optionally a cationic polymeric skin conditioning agent, and water, wherein the polar oil has an average carbon chain length of from about 12 to about 16 carbon atoms and wherein the water-soluble surfactants have an average carbon chain of from about 10 to about 18 carbon atoms. These compositions may also comprise a hydrotrope. These compositions may optionally comprise a perfume or cosmetic oil. These compositions deliver excellent product thickening and rheological attributes, in storage, in dispensing and in use, in combination with good efficacy benefits such as mildness, a moisturized skin feel, rinsibility, skin conditioning, product stability and lather attributes.Type: GrantFiled: December 30, 1998Date of Patent: February 20, 2001Assignee: The Procter & Gamble CompanyInventors: Alan Brooks, Charles Marie Alain Du Reau
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Patent number: 6191084Abstract: A composition for cleaning a print roller such as an anilox roller includes a soap or cleansing agent having a plurality of grit particles, an organic acid, an emulsifier, and water. A solvent is mixed with the cleansing agent to complete the composition. A method of utilizing the cleaning composition includes providing the composition, selecting an applicator, and mixing the composition. The method then includes wiping the composition repeatedly over the print roller using the applicator until the surface and plurality of cells in the roller surface are substantially free of dried ink and other contaminants.Type: GrantFiled: June 8, 2000Date of Patent: February 20, 2001Assignee: LBL Enterprises, LLC.Inventor: Lee A. Christianson
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Patent number: 6191085Abstract: A method is provided for treating a plurality of semiconductor substrates using the same aqueous SC-1 solution which solution removes and/or inhibits contamination of the semiconductor surfaces by metallic ions present in the solution or on the substrate surface comprising a basic solution containing hydrogen peroxide and an oxidation-resistant chelating additive such as CDTA in an amount effective to provide the desired treatment results. The SC-1 solution may be the conventional 5:1:1 (water:NH4OH:H2O2) solution or a dilute solution such as a 5:x:1 to 200:x:l solution wherein x is 0.025 to 2.Type: GrantFiled: May 10, 1999Date of Patent: February 20, 2001Assignee: International Business Machines CorporationInventors: Emanuel I. Cooper, Scott A. Estes, Glenn W. Gale, Rangarajan Jagannathan, Harald F. Okorn-Schmidt, David L. Rath
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Patent number: 6191086Abstract: Non-corrosive cleaning compositions that are aqueous based and useful for removing photoresist, plasma etch and CMP residues from a substrate. One preferred cleaning composition comprises: (i) a hydroxylamine or a hydroxylamine salt compound; (ii) at least one fluorine-containing compound; and (iii) water. Another cleaning composition comprises: (i) a compound selected from the group consisting of: an amine, a quatenary ammonium hydroxide, and ammonium hydroxide; (ii) at least one fluorine-containing compound; and (iii) water.Type: GrantFiled: December 15, 1999Date of Patent: February 20, 2001Assignee: Arch Specialty Chemicals, Inc.Inventors: Vincent G. Leon, Kenji Honda, Eugene F. Rothgery
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Patent number: 6191087Abstract: A solvent that is biodegradable, provides effective solvency for a broad range of tasks and is generally benign to human health is disclosed. This solvent is a mixture of a lactate ester and an edible oil ester having a closed cup flash point in excess of 60° C., and can include other non-halogenated solvents and surfactants.Type: GrantFiled: June 5, 2000Date of Patent: February 20, 2001Assignee: Vertec BioSolvents, LLCInventors: James E. Opre, Eugene P. Bergemann, Mark Henneberry
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Patent number: 6191088Abstract: The present invention relates to an automatic dishwashing composition which can be in the form of a tablet which generally comprises an alkali metal phosphate detergent builder salt, an alkali metal carbonate, a dialkali metal disilicate, a nonionic surfactant, an alkali metal metasilicate, a polymer containing sulfonic acid groups, a chlorine bleach compound, a hydrotrope and a clay.Type: GrantFiled: June 1, 1999Date of Patent: February 20, 2001Assignee: Colgate-Palmolive Co.Inventors: Gary Binstock, Bruce Cummings, Divaker Kenkare, Kevin Kinscherf, Steve Phillips
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Patent number: 6191089Abstract: An automatic dishwashing composition which is in the form of a tablet generally comprises an alkali metal phosphate detergent builder salt, an alkali metal carbonate, a lubricant, a dialkali metal disilicate, a nonionic surfactant, a polymer containing sulfonic acid groups, a wax coated chlorine bleach compound, and optionally an anionic surfactant.Type: GrantFiled: December 15, 1999Date of Patent: February 20, 2001Assignee: Colgate-Palmolive CompanyInventors: Philip Gorlin, Leonard Zyzyck, Gary Jakubicki
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Patent number: 6191090Abstract: An improvement is described in all purpose liquid cleaning composition and microemulsion composition which are especially effective in the removal of oily and greasy soil and contains an anionic detergent, an ethoxylated/propoxylated nonionic surfactant, a cosurfactant, a hydrocarbon ingredient, and water.Type: GrantFiled: October 22, 1999Date of Patent: February 20, 2001Assignee: Colgate Palmolive CompanyInventors: Myriam Mondin, Nicole Andries, Jean Massaux
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Patent number: 6191091Abstract: The cleaning compound for a water dispenser includes four ingredients: a) N′alkyl dimethyl Benzyl Ammonium Chloride, within the range of 0.08 to 0.1% by weight; b) citric acid, of about 20% by weight of the total solution; c) propylene glycol (food grade), about 4% by weight; and d) sodium hydroxide (food grade), in sufficient quantity to neutralize the solution to a pH range preferably between 2.6 and 4.5. During the initial clean-up steps, and contrarily to prior art cleaning methods, the cleaning method does not require complete purge of the inner water reservoir from drinking water, due to the tacky nature of the cleaning compound which can still be effective in diluted state and in a submerged environment.Type: GrantFiled: February 27, 1998Date of Patent: February 20, 2001Inventor: Marcel Raymond
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Patent number: 6191092Abstract: A stabilized liquid enzyme preparation containing a cleaning-active enzyme, a solvent selected from the group consisting of ethylene glycol, propylene glycol, glycerol, and mixtures thereof, and a stabilizer comprising a basic nitrogen compound selected from the group consisting of N,N-bis-(3-aminopropyl)-dodecyl amine, a salt of N,N-bis-(3-aminopropyl)-dodecyl amine, and mixtures thereof. Also, a method of cleaning an article by diluting the stabilized liquid enzyme preparation with water in a weight ratio of enzyme preparation to water of 1:500 to 1:5000 to form a cleaning solution, adding to the cleaning solution 0.01% to 0.2% by weight, based on the weight of cleaning solution, of a buffer concentrate to adjust the pH of the cleaning solution to 7 to 10; and contacting the article with a portion of the cleaning solution to effect cleaning thereof.Type: GrantFiled: October 22, 1999Date of Patent: February 20, 2001Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Siegfried Bragulla, Andreas Potthoff, Wilfried Serve
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Patent number: 6191093Abstract: Cotton soil release polymers comprising water soluble and/or dispersible, modified polyamines having functionalized backbone moieties and improved stability toward bleach. Also, laundry detergent compositions comprising these cotton soil release polymers.Type: GrantFiled: February 18, 2000Date of Patent: February 20, 2001Assignee: The Procter & Gamble CompanyInventors: Randall Alan Watson, Eugene Paul Gosselink
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Patent number: 6191094Abstract: An alkaline aqueous cleaning composition for cleaning a substrate contaminated with industrial-type soil contaminants contains (i) an aqueous portion and (ii) an active-ingredient portion composed of (A) an alkalinity-providing agent and (B) a surfactant mixture containing (a) an active concentration of an ethoxylated C12-14 alkanol surfactant having an HLB value at 25° C. of from 8 to 12 and (b) an active concentration of at least one aminocarboxylic acid surfactant of the general formula R—N(H)—R′, wherein R is a straight or branched chain aliphatic organic group having from 10 to 20 carbon atoms, and R′ is a straight or branched chain carboxylic acid having from 1 to 7 carbon atoms. At an active-concentration ratio of surfactant (a) to surfactant (b) of about 2.5:1, the surfactants have a synergistic effect on the cleaning composition's ability to remove certain types of industrial-soil contaminants.Type: GrantFiled: November 5, 1998Date of Patent: February 20, 2001Assignee: Church & Dwight Co., Inc.Inventors: Francis R. Cala, Richard A. Reynolds
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Patent number: 6191095Abstract: A particulate detergent composition having a bulk density of 700 g/l or less and containing at least 10 wt % (preferably at least 15 wt %) of organic detergent surfactant comprises a base powder composed of at least two granular components. Less than 80% by weight, preferably less than 66% by weight, of the base powder has a compressibility (measured at 20-25° C. and about 40% relative humidity) of 17% or more. Preferably one of the components of the base powder is a granule containing a high level (at least 60 wt %) of anionic surfactant.Type: GrantFiled: May 26, 1998Date of Patent: February 20, 2001Assignee: Lever Brothers Company, a division of Conopco, Inc.Inventors: William Derek Emery, Terry Instone, Seeng Djiang Liem, Gilbert Martin Verschelling
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Patent number: 6191096Abstract: A spray-dried amorphous alkali metal silicate compound which provides multiple-cycle washing performance. The silicate compound has a molar ratio of M2O to SiO2 of 1:1.5 to 1:3.3 wherein M represents an alkali metal. The compound contains 0.5 to less than 30% by weight of anionic surfactant and has an absorption capacity for liquid components which is at least 20% higher than that of the same quantity of the alkali metal silicate compound which is free from anionic surfactant.Type: GrantFiled: August 18, 1997Date of Patent: February 20, 2001Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Kathrin Schnepp-Hentrich, Rene-Andres Artiga Gonzalez, Katrin Burmeister, Hubert Freese, Manfred Greger, Bernd Larson, Volker Bauer, Peter Sandkuehler, Wilfried Raehse
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Patent number: 6191097Abstract: A process for producing solid detergent granular materials is presented involving (a) forming an aqueous surfactant paste of an anionic surfactant, an amphoteric surfactant or mixtures thereof, and (b) drying and granulating the aqueous paste in a horizontal thin-layer evaporator or dryer having rotating fittings, wherein the drying is carried out at a temperature of 120° C. to 130° C. The process produces granules having a bulk density greater than 600 grams/liter and a uniform particle size distribution.Type: GrantFiled: August 25, 1999Date of Patent: February 20, 2001Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Thomas Lueder, Konstantinos Scholinakis, Bernhard Gutsche, Christoph Breucker, Norbert Wrede
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Patent number: 6191098Abstract: A water-soluble polyvinylpyrridinium derivative containing a quaternary nitrogen and an anionic moiety selected from a sulfonate and/or a carboxylate functionality, said polyvinylpyrridinium derivative having the structure wherein a is a repeating unit of 1 to 100; b is a repeating unit of 0 to 99; c is a repeating unit of 0 to 99; d is a repeating unit of 0 to 99; R is selected from the group consisting of (CR1R2)m1, benzene, and substituted benzene; Y is selected from the group consisting of (CR3R4)m2, benzene, and substituted benzene; substituted benzene is independently a benzene substituted with a group selected from the group consisting of amino moeity, nitro moiety, halogen moiety, and combinations thereof; Z is derived from an ethylenically unsaturated monomer; m1 and m2 are independently 0 to 10; M+ is independently a cation wherein M is selected from the group consisting of hydrogen, ammonia, alkali metals, alkaline earth metals, zinc, copper, organic amines, amino acids, andType: GrantFiled: April 28, 1999Date of Patent: February 20, 2001Assignee: National Starch and Chemical Investment Holding CorporationInventors: Klein A. Rodrigues, John S. Thomaides
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Patent number: 6191099Abstract: This invention is directed to an improved method for removing hydrocarbon-containing soils. The invention consists of preparing a detergent composition and applying the composition to the surface to be cleaned. Broadly, the detergent composition consists of from 1 to 99% by weight of at least one polyalkoxylated amine and from 99-1% by weight of at least one water-soluble surfactant. Other constituents may be added to enhance performance. The invention has desirable foamability characteristics.Type: GrantFiled: April 19, 1999Date of Patent: February 20, 2001Assignee: Tomah Products, Inc.Inventor: Terry Crutcher
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Patent number: 6191100Abstract: This invention relates to a detergent composition comprising an anionic surfactant and a cationic surfactant, an acid source and an alkali source capable of reacting together in the presence of water to produce a gas.Type: GrantFiled: March 2, 1999Date of Patent: February 20, 2001Assignee: The Procter & Gamble CompanyInventors: Stuart Clive Askew, Graham Alexander Sorrie
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Patent number: 6191101Abstract: A stable, pourable and water dispersible fabric softening composition comprising: (i) from about 2% to about 35%, by weight, of a combination of softening components (A) and (B) wherein: (A) is a cationic fabric softening compound; and (B) is a fatty amide compound; (ii) from about 0 to about 10%, by weight, of a polysiloxane; and (iii) balance water and optionally adjuvants selected from the group consisting of perfumes; dyes; sequestrants; thickeners; and anti dye-transfer polymeric materials.Type: GrantFiled: May 26, 2000Date of Patent: February 20, 2001Assignee: Colgate-Palmolive Co.Inventors: Alain Jacques, Leopold Laitem
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Patent number: 6191102Abstract: This invention relates the use of glucagon-like peptides such as GLP-1, a GLP-1 analog, or a GLP-1 derivative in methods and compositions for reducing body weight.Type: GrantFiled: October 30, 1997Date of Patent: February 20, 2001Assignee: Eli Lilly and CompanyInventors: Richard D. DiMarchi, Suad Efendic
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Patent number: 6191103Abstract: It has been found that agents which inhibit the interaction between the band 3 protein and its ligand (hereafter sometimes referred to as “interaction inhibitors” or “inhibitors”), CD36/thrombospondin, can also be used to enhance thrombolysis. The inhibitors can be peptides which contain sequences present in exofacial loops of the band 3 protein, or can be non-natural, D-isomer forms of the same sequences, or can be peptides, peptidomimetics, or non-peptidic molecules which interfere with band 3 protein—ligand interactions. One preferred group of such inhibitors comprises peptides characterized by the sequence motif Z2Z3Z2UX−UUUX− (SEQ ID NO:44), wherein Z2 represents a hydrophobic residue, U represents unobstructive residues, Z3 is either Z2 or an unobstructive residue and X− represents negatively charged residues.Type: GrantFiled: December 5, 1997Date of Patent: February 20, 2001Assignees: The Regents of the University of California, Center for Blood ResearchInventors: Stephen B. Shohet, Irwin Sherman, Ulrich von Andrian
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Patent number: 6191104Abstract: Isolated receptors for IL-17, DNA's encoding such receptors, pharmaceutical compositions made therefrom, and methods of treatment using the IL-17 receptors are disclosed. The isolated receptors can be used to regulate an immune response.Type: GrantFiled: February 11, 1998Date of Patent: February 20, 2001Assignee: Immunex CorporationInventors: Melanie K. Spriggs, William C. Fanslow
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Patent number: 6191105Abstract: A therapeutic formulation comprising a microemulsion of a therapeutic agent in free and/or conjugatively coupled form, wherein the microemulsion comprises a water-in-oil (w/o) microemulsion including a lipophilic phase and a hydrophilic phase, and has a hydrophilic and lipophilic balance (HLB) value between 3 and 7, wherein the therapeutic agent may for example be selected from the group consisting of insulin, calcitonin, ACTH, glucagon, somatostatin, somatotropin, somatomedin, parathyroid hormone, erythropoietin, hypothalamic releasing factors, prolactin, thyroid stimulating hormones, endorphins, enkephalins, vasopressin, non-naturally occurring opioids, superoxide dismutase, interferon, asparaginase, arginase, arginine deaminease, adenosine deaminase, ribonuclease, trypsin, chymotrypsin, papain, Ara-A (Arabinofuranosyladenine), Acylguanosine, Nordeoxyguanosine, Azidothymidine, Dideoxyadenosine, Dideoxycytidine, Dideoxyinosine Floxuridine, 6-Mercaptopurine, Doxorubicin, Daunorubicin, or I-darubicin, ErythromType: GrantFiled: October 27, 1997Date of Patent: February 20, 2001Assignee: Protein Delivery, Inc.Inventors: Nnochiri Nkem Ekwuribe, Muthukumar Ramaswamy, Balasingam Radhakrishnan, HameedSulthan S. Allaudeen
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Patent number: 6191106Abstract: EGF muteins in which the histidine at position 16 is replaced with a neutral or acidic amino acid exhibit activity at pHs lower than obtainable with wild type EGF.Type: GrantFiled: March 20, 1996Date of Patent: February 20, 2001Assignee: Chiron CorporationInventors: Guy T. Mullenbach, Jeffrey M. Blaney, Steven Rosenberg
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Patent number: 6191107Abstract: The present invention provides a complex of human growth hormone and zinc containing human growth hormone and zinc at a molar ratio of about 1:1.6 to about 1:2.4, and a sustained-release preparation which comprises the complex of human growth hormone and zinc and a biodegradable polymer and which has a high entrapment ratio of human growth hormone and exhibits a stable sustained-release suppressing the initial burst.Type: GrantFiled: September 11, 1998Date of Patent: February 20, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Yutaka Yamagata, Masafumi Misaki, Susumu Iwasa
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Patent number: 6191108Abstract: Disclosed are novel protein and peptide compositions comprising soluble and bound forms of immunologically-active blood group antigens including mammalian Rh antigens. In preferred embodiments methods for the isolation and purification of serologically-active human Rh antigens such as D, c, C, E, and e are disclosed. Also disclosed are methods for the adsorption of immunologically-active Rh antigens to solid supports. Diagnostic kits, methods, and devices for the detection of Rh antibodies in clinical and non-clinical samples are also disclosed. Devices, compositions and methods for the isolation, purification and quantitation of anti-Rh antibodies from solution are also provided.Type: GrantFiled: October 1, 1998Date of Patent: February 20, 2001Inventors: L. Scott Rodkey, Marwan A. Yared, Kenneth J. Moise, Jr.
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Patent number: 6191109Abstract: The present invention provides methods of treating pathologic conditions associated with intestinal ischemia. In the methods, patients at risk for or suffering from intestinal ischemia are treated with a heparin-binding epidermal growth factor product.Type: GrantFiled: October 29, 1998Date of Patent: February 20, 2001Assignee: Children's Hospital, Inc.Inventors: Gail E. Besner, Srikumar B. Pillai
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Patent number: 6191110Abstract: A method of treating a wound of a mammalian subject in rneed of such treatment, to promote healing thereof, comprising administering to the subject, e.g., to the wound locus, a composition comprising a fibroblast and keratinocyte proliferatingly effective amount of an amphipathic peptide, preferably an amphipathic peptide which is antimicrobially effective at such locus. A method is also disclosed of stimulating the accelerated growth of dermal tissue in a tissue culture containing same, comprising applying to the tissue culture a fibroblast and keratinocyte proliferatingly effective amount of an amphipathic peptide, by which the dermal tissue may be grown to produce skin for skin grafting purposes, utilizing a dermal tissue culture containing dermal tissue material of a skin graft recipient of such skin. Novel amphipathic peptides suitable for use in such methods are disclosed.Type: GrantFiled: January 19, 1999Date of Patent: February 20, 2001Assignee: Demegen, Inc.Inventors: Jesse M. Jaynes, Gordon R. Julian
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Patent number: 6191111Abstract: A method for enhancing such biobypass techniques as angiogenesis, trans-myocardial revascularization, percutaneous myocardial revascularization, and myocardial cell proliferation by using the means for increasing of coronary blood flow to both instantly relieve the ischemic symptoms and stimulate the growth of new blood vessels. Intra-aortic balloon pumping and other counterpulsation means are identified as preferred means for increasing of coronary blood flow.Type: GrantFiled: February 17, 1999Date of Patent: February 20, 2001Assignee: Datascope Investment Corp.Inventor: Boris Leschinsky
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Patent number: 6191112Abstract: Disclosed are methods for treatment of humans exposed to bacterial endotoxin in circulation by administration of bactericidal/permeability-increasing (BPI) protein products. Serologically and hematologically verifiable alleviation of endotoxin mediated increases in circulating cytokines, fibrinolysis and coagulation factors and changes in lymphocyte counts are observed upon such treatment. Also observed is alleviation of endotoxin mediated decreases in systemic vascular resistance index (SVRI) and concomitant increases in cardiac index (CI).Type: GrantFiled: September 2, 1999Date of Patent: February 20, 2001Assignee: Xoma CorporationInventors: Nadav Friedmann, Patrick J. Scannon, Sander J. H. van Deventer, Marijke A. M. von der Mohlen, Nancy Wedel
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Patent number: 6191113Abstract: A peptide comprising a peptide (A) of an amino acid sequence being abundant in basic amino acid residues and a peptide (B) of an amino acid sequence comprising at least two consecutive, hydrophobic amino acid residues wherein the peptide (B) is linked to the C-terminal of the peptide (A) directly or via several amino acid residues. The novel peptide of the present invention has the activity to inhibit growth of smooth muscle cells and a pharmaceutical composition comprising the peptide is useful for preventing or treating pathological conditions associated with growth of smooth muscle cells such as arteriosclerosis, restenosis after angioplasty, luminal stenosis after grafting blood vessel and smooth muscle sarcoma.Type: GrantFiled: April 24, 1998Date of Patent: February 20, 2001Assignee: Juridical Foundation The Chemo-Sero-Therapeutic Research InstituteInventors: Yo Nakahara, Saburo Hara, Yuichi Kamikubo, Sumiyo Takemoto, Seiji Miyamoto
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Patent number: 6191114Abstract: The present invention relates a novel immunological effect of one peptide from Limulus anti-LPS factor protein. The immunological effect are, (1) induce an antiviral state in both the Hep-2 and MDBK cell lines, (2) Supernatant from human mononuclear cells stimulated with peptide Limulus anti-LPS factor (LALF) is able to induce antiviral effect on Hep-2 cell line by mean of IFN-&ggr; (3) LALF peptide is able to modulate the immune response in vitro and in vivo. The present invention can be used in therapeutic and/or prophylactic treatment regimens of humans and animals to enhance their immune responses, without stimulating the production of certain biochemical mediators (e.g., TNF-&agr;,) that can cause detrimental effects, such as fever and inflammation.Type: GrantFiled: September 25, 1998Date of Patent: February 20, 2001Assignee: Centro de Ingenieria Genetica Y BiotecnologiaInventors: Maribel Guerra Vallespi, Manuel de Jesus Arana Rosainz
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Patent number: 6191115Abstract: The present invention relates to a class of heptapeptide analogs of LHRH. These compounds are useful in the treatment of disease conditions which are mediated by reproductive hormones, including benign prostate hyperplasia, prostate tumors, breast and ovaries tumors, cryptorchidism, hirsuitism, gastric motility disorders, dysmenorrhea, and endometriosis.Type: GrantFiled: January 15, 1999Date of Patent: February 20, 2001Assignee: Abbott LaboratoriesInventors: Fortuna Haviv, Wesley J. Dwight, Charles J. Nichols, Jonathan Greer
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Highly soluble, hydratable, viscous, solution stable pyrodextrins, process of making and use thereof
Patent number: 6191116Abstract: The present invention provides novel pyrodextrins which are substantially 100% soluble in water, and substantially hydratable in a solution which has low free water, at ambient temperature, have high viscosities relative to a canary dexrin and are solution stable. These dextrins are prepared by preferably acidifying the starch, and dextrinizing under substantially anhydrous conditions for a time and at a temperature sufficient to result in the desired end product.Type: GrantFiled: April 27, 1998Date of Patent: February 20, 2001Assignee: National Starch and Chemical Investment Holding CorporationInventors: James J. Kasica, Vincent Choe, Erik Kouba, Elizabeth Styer -
Patent number: 6191117Abstract: Methods are disclosed for the acute and chronic treatment of obesity using drugs whose mechanism includes the interaction and antagonism of the kainate/AMPA receptor. Methods are disclosed for employing the drug topiramate (topomax) as monotherapy or in combination therapy with lamotrigene, valproic acid, valproic acid and carbamezepine combination, or felbamate (felbatol).Type: GrantFiled: July 10, 2000Date of Patent: February 20, 2001Inventor: Walter E. Kozachuk
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Patent number: 6191118Abstract: An erythromycin A derivative represented by Formula wherein R1 is a group represented by the formula: a group represented by the formula: (c) pyridylacetyl, (d) cycloalkylmethyl or (e) 1,2 bis-(ethoxycarbonyl)vinyl, R2 is the same group as defined for R1, hydrogen, alkyl, alkanoyl, alkoxycarbonyl, R1 and R2 together may form ═CH—R14, or R1 and R2 together with the nitrogen atom to which they are attached may form: R3 is hydrogen, alkyl or cinnamyl, R4 is hydrogen, acetyl, ethylsuccinyl or nicotinoyl, A is —OC(═O)—R17, —OC(═O)—CH2—R17, —OC(═O)—NH—R17, —O—R17 or —OC(═O)—O—R17, and R5 and R6 are each hydrogen or alkyl.Type: GrantFiled: April 23, 1999Date of Patent: February 20, 2001Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Toshifumi Asaka, Masato Kashimura, Akiko Matsuura, Tomohiro Sugimoto, Tetsuya Tanikawa, Takaaki Ishii
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Patent number: 6191119Abstract: A method for treating a patient having a disease associated with undesirable or uncontrolled cell proliferation such as cancer and restenosis is provided. The method comprises: delivering to the patient a therapeutically effective amount of 9-nitro-20(S)-camptothecin in combination with an effective amount of an antibiotic agent such as doxorubicin.Type: GrantFiled: October 15, 1999Date of Patent: February 20, 2001Assignee: SuperGen, Inc.Inventor: Joseph Rubinfeld
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Patent number: 6191120Abstract: Contraceptive activity as well as anti-viral protection can be provided by contraceptive compositions containing a pyrimidine-based nucleoside or nucleotide exhibiting spermicidal or sperm-immobilizing activity. In one example, the active ingredient contains a thymine ring (e.g. AZT) that has 5-halo, 6-alkoxy substitution. Additional improvements in anti-HIV activity for certain AZT derivatives are seen by providing the pentose ring of AZT with aryl phosphate substitution.Type: GrantFiled: March 25, 1998Date of Patent: February 20, 2001Assignee: Wayne Hughes InstituteInventors: Osmond D'Cruz, Fatih M. Uckun, Taracad Venkatachalam
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Patent number: 6191121Abstract: Polyenylphosphatidylcholine is topically applied to treat skin damage, such as contact dermatitis (particularly diaper area dermatitis), atopic dermatitis, xerosis, eczema (including severe hand and foot eczema), rosacea, seborrhea, psoriasis, thermal and radiation burns, other types of skin inflammation, and aging. Typical compositions contain from about 0.25% to about 10% of a polyenylphosphatidylcholine preparation obtained from natural sources such as soybean oil which contains at least about 25% by weight, preferably about 40% or more, dilinoeoylphosphatidylcholine.Type: GrantFiled: April 6, 2000Date of Patent: February 20, 2001Inventor: Nicholas V. Perricone
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Patent number: 6191122Abstract: A partially hydrophobic precipitated silica having a methanol wettability of 10 to 49%, in particular with a DBP uptake on a dry basis of greater than 250 g/100 g and a mean particle size of 1 to 12 &mgr;m and/or a carbon content of 0.3 to 1.85% and/or a loss on drying of 2.6 to 10.0% and/or a pH value of 5.5 to 10.0, is prepared by mixing the amount of water-repellent agent with the precipitated silica suspension at very short residence time and low pH value, filtering off the solid substance, washing free of salt, drying, post-treating thermally and milling. The partially hydrophobic precipitated silica can be used in active substance formulations and active substance formulations of hydrolysis-sensitive substance and in defoaming agents.Type: GrantFiled: March 28, 1997Date of Patent: February 20, 2001Assignee: Degussa Hüls AktiengesellschaftInventors: Heinz-Günter Lux, Karl Meier, Astrid Müller, Rolf Oelmüller, Anja Ramb
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Patent number: 6191123Abstract: Novel organic arsenic compounds are described as cytotoxic agents with potent anti-tumor activity against cancer cells and particularly, with regard to human leukemic cells and breast cancer cells.Type: GrantFiled: June 23, 1999Date of Patent: February 20, 2001Assignee: Parker Hughes InstituteInventors: Fatih M. Uckun, Xing-Ping Liu