Abstract: The invention relates to a membrane system for controlled tissue regeneration of the periodontium, comprising a resorbable polymer membrane and anti-adhesion molecules.

Abstract: Preparation of a nutritional supplement, comprising: providing a mixture containing an isoflavanoid and a solvent; removing a sugar portion from the isoflavanoid to produce an isoflavanoid aglycone; concentrating the aglycone to at least 10 wt % in the mixture; and coupling the aglycone with an amphiphilic carrier to produce micelles having an average diameter of less than about 1000 nm.

Abstract: The present invention provides orally administrable pharmaceutical compositions containing an inhibitor of gastrointestinal lipase, and at least one compound selected from the group consisting of psyllium husk, its seeds and leaves thereof. Methods are provided for preventing and treating anal leakage of oil in a patient to whom a composition containing an inhibitor of gastrointestinal lipase is orally administered.

Abstract: A feed composition for animals (livestock, poultry, fish or pet) which contains poly-&ggr;-glutamic acid (and/or degradated product thereof) and, a method for reducing body fat acumulation in animals which comprises feeding animals with a feed composition containing poly-&ggr;-glutamic acid.

Abstract: A paste or cream formulation which can be sterilised comprises an emulsion formed of a wax or oil, an emulsifier and water and an insoluble material which forms a gel in the presence of water. A bandage or wound dressing having the paste on a surface thereof is also disclosed. A method of making a sterilisable paste comprises forming an emulsion of oil or wax in water, forming a slurry of a gel-forming material in a polyol and then adding the slurry to the emulsion while mixing.

Abstract: A gel for use in dressing a wound and a process for the manufacture of a gel are disclosed. The gel comprises a monovalent salt of a polygalacturonic, acid derivative (such as sodium pectate) a carboxy-polysaccharide (such as a monovalent salt of a carboxycellulose derivative or a monovalent salt of an alginic acid derivative) and multivalent ions providing ionic cross-links between the monovalent salt and the carboxy-polysaccharide.

Abstract: Paucilamellar lipid vesicles containing lipid bilayers at least two lipid bilayers formed of surfactant materials, each of the bilayers comprising a glucoside primary amphiphile and a steroid. The vesicles may have either an aqueous or oil-filled central cavity and are particularly useful for delivering dermatological, cosmetic and pharmaceutical formulations. A method of manufacture for these vesicles is also disclosed.

Abstract: Liquid softgel fill formulations containing ibuprofen in free acid form, and softgel capsules comprised of a gelatin sheath enclosing such fill formulations, are prepared by dissolving more than 30% of ibuprofen in free acid form in polyethylene glycol and at least 10% by weight of a polyvinylpyrrolidone having an average molecular weight of from about 2,000 to about 54,000. The formulations may also include a surfactant to increase the bioavailability of the ibuprofen.

Abstract: A pharmaceutical capsule composition for oral administration exhibiting controllable, satisfactory release profiles of both loratadine and pseudoephedrine or its salts, which comprises: (a) a plurality of rapid-release pellets (pellets A), each pellet containing (i) a therapeutically effective amount of loratadine, (ii) pseudoephedrine or a pharmaceutically acceptable salt thereof, and (iii) one or more pharmaceutically acceptable excipients; and (b) a plurality of extended-release pellets (pellets B), each pellet containing (i) pseudoephedrine or a pharmaceutically acceptable salt thereof and (ii) one or more pharmaceutically acceptable excipients, which are coated with a water-insoluble polymer in an amount ranging from 2 to 30 wt % and a wet-blocking agent selected from the group consisting of magnesium stearate, talc, fatty acid ester and a mixture thereof in an amount ranging from 2 to 30 wt %, based on the total weight of pellets B.

Abstract: Compositions for pharmaceutical and other uses for preparing clear aqueous solutions containing bile acids which do not form precipitates over selected ranges of pH values of the aqueous solution and methods of making such solutions. The compositions of the invention comprise water; a bile acid in the form of a bile acid, bile acid salt, or a bile acid conjugated with an amine by an amide linkage; and a high molecular weight aqueous soluble starch conversion product. The composition remains in solution without forming a precipitate over a range of pH values and, according to one embodiment, remains in solution for all pH values obtainable in an aqueous system. The composition, according to some embodiments, may further contain a pharmaceutical compound in a pharmaceutically effective amount.

Abstract: Programmed-release ambroxol·HCl pharmaceutical dosage forms, adopted to maintain a therapeutically effective plasma level thereof for about 24 hours, comprise a plurality of inert core microgranules of a variety of particle sizes ranging from 0.3 to 1.2 mm, such inert core microgranules being coated with alternating microlayers of (1) micronized ambroxol hydrochloride active agent and (2) delayed-release film material, such coated microgranules including an external microlayer of delayed-release film material, and such coated mi.crogranules having particle sizes ranging from 0.6 to 1.5 mm.

Abstract: Sustained release drug formulations contain the pharmaceutical itself and a three component release rate controlling matrix composition. The three components of the matrix composition are (1) water insoluble polymer, such as ethyl cellulose, (2) pH dependent gelling polymer, such as sodium alginate, and (3) a pH independent gelling polymer, such as hydroxypropyl methylcellulose. The drug release rate can be adjusted by changing the amount of one or more of these components of the composition.

Abstract: A biodegradable insect repellant that breaks down in the presence of water to minimize solid waste, comprising a water soluble substrate substantially comprising foamed vegetable starch, and cedar oil carried in the substrate. The substrate is preferably made of corn and or potato starch. The cedar oil may be from about 0.01 to about 10 times the weight of the substrate. A coloring agent may optionally be provided in the cedar oil to impart color to the insect repellant. Because the substrate is made from a water soluble starch, it dissolves in water leaving little or no solid waste.

Abstract: Dosage form unit is provided to deliver one or more beneficial agents into a fluid, such as liquid enteral nutritional product. The dosage form unit includes a core containing at least one beneficial agent, preferably a marker dye, which is dispersible in the fluid. The core also contains a compatible binding agent to bind the beneficial agent together. Additional components of the core may include a plasticizer, a standard flow agent, a lubricant, additional tableting aids and at least one hydrophilic agent. A latex coating encases the core. The latex coating includes a mixture containing a substantially hydrophobic base material, preferably formed from an emulsion of cellulose acetate microspheres, which is capable of defining a matrix-type membrane, and at least one hydrophilic component being dispersible in the fluid. A dispersible beneficial agent is preferred as one of the hydrophilic components of the latex coating to allow immediate release of the beneficial agent therefrom.

Abstract: This invention relates compositions and methods for increasing the uptake of polynucleotides into cells. Specifically, the invention relates to vectors, targeting ligands, and polycationic agents. The polycationic agents are capable of (1) increasing the frequency of uptake of polynucleotides into a cell, (2) condensing polynucleotides; and (3) inhibiting serum and/or nuclease degradation of polynucleotides.

Abstract: Preparations of non-steroidal analgesics with antipyretic and antiinflammatory effect are obtainable by extrusion and shaping of a melt, comprising, besides one or more active ingredients, a mixture of a) 40-99.5% by weight of a homopolymer of N-vinylpyrrolidone with a Fikentscher K value of 30, b) 0.25-59.75% by weight of a water-soluble copolymer of N-vinylpyrrolidone, and c) 0.25-10% by weight of one or more physiologically acceptable salts of sodium or potassium, where the stated amounts are based on the total of components a), b) and c).

Abstract: The present invention describes a crosslinked aliphatic polyoxaamide polymer and blends thereof that may be used to produce hydrogels, surgical devices such as catheters, molded devices, and the like. The crosslinked aliphatic polyoxaamide of the present invention are formed by crosslinking an aliphatic polyoxaamide having a first divalent repeating unit of formula I: [X—C(O)—C(R1)(R2)—O—(R3)—O—C(R1)(R2)—C(O)—]  I and a second repeating unit selected from the group of formulas consisting of: [—Y—R17—]T,  II [—O—R5—C(O)—]B,  III and ([—O—R9—C(O)]P—O—)LG  XI and combinations thereof, wherein X and Y are selected from the group consisting of —O— and —N(R)—, provided both X and Y are not both —O— and may be blended with a second polymer that is preferably biocompatable.

Abstract: Topical gelled compositions comprising a drug which causes vasodilation, and optionally prostaglandin E1, dispersed within a polymer matrix, and methods of treating sexual dysfunction, including both male and female sexual dysfunction, using said compositions.

Abstract: A hemodialysis acid concentrate which includes, before mixing, sodium chloride powder and sometimes dextrose powder as a powder component, and a liquid component which contains some or all of the following: potassium chloride, magnesium chloride, sodium chloride, dextrose, calcium chloride, and an acid from the group lactic acid, acetic acid, and citric acid. The liquid and powder components are added to a specified volume of water to make a final acid concentrate. The individual components are easily inspected for quality control and the shipping weight is greatly reduced compared to conventional liquid acid concentrates.

Abstract: This invention relates to a method for preparation of biologically active substances and has the following characteristic features: (a) nacre is reduced to a powder whose grain size is less than approximately 200 &mgr;m; (b) it is placed in close contact with an aqueous solvent, (c) at the end of the contact period, the insoluble fraction is separated out to give the aqueous fraction; (d) the solvent of the aqueous fraction is concentrated to separate out the soluble or water-transportable fraction of the nacre, which is made up of biologically active substances with essentially no mineral components. The invention likewise relates to the products obtained by this method, their use for medicinal purposes and the compositions containing them.

Abstract: A method for reducing a risk of carcinogenesis in a subject comprising administering a dose of calcium to the subject that is effective to reduce carcinogenesis. Particularly provided is a method for reducing the risk of recurrence of colorectal adenomas, comprising administering a dose of calcium carbonate effective to reduce the risk of colorectal adenomas. In an example, 1200 mg of elemental calcium (supplied in 3000 mg of calcium carbonate) administered twice daily resulted in decreased risk of recurrent colorectal adenomas in patients with a history of colorectal adenomas.

Abstract: There is disclosed a pesticidal composition comprising by volume, approximately 40 to 60% eucalyptus oil, 10 to 30% cajaput oil, 10 to 30% lemongrass oils and 4 to 20% of surfactant. The composition is used in a method for controlling pesticidal activity at a locus which comprises applying an effective amount of the composition thereto.

Abstract: Stable aqueous compositions of biologically active oils for the preparation of optically clear products for use in human or animal healthcare, for example beverages, are prepared.

Abstract: Coenzyme Q is added to a feed composition for broilers, preferably in an amount of from 0.0005 to 0.003% by weight of the total amount of the composition, and the composition is controlled to have a metabolizable energy value of not smaller than 3150 kcal/kg. The coenzyme Q-containing composition is pelletized into pellets. This is fed to broilers for 7 days or longer while the broilers being fed therewith are of 10 to 35-days age. Feeding broilers with the pelletized, coenzyme Q-containing feed composition provided by the invention makes it possible to well prevent the broilers from having ascites and to increase the growth rate of the broilers, whereby raising rate of the broilers is increased and the rearing period thereof is shortened. According to the feeding method of the invention, the productivity in broiler raising is much increased.

Abstract: The present invention relates to a method for producing a flavor base which then can be used to form savory flavor or flavor enhancer products. The method involves enzymatically hydrolyzing cereal grain cereal protein, in particular defatted wheat germ, to produce the flavor base.

Abstract: The present invention relates to a bread improver composition containing lipase, hemicellulase and amylase, preferably in combination with shortening. The enzyme preparation of the invention has an advantageous effect on the crumb softness of the final bakery product. The combination of the enzyme preparation of the invention and shortening can replace emulsifiers like SSL and monoglycerides which are used as a crumb softener.

Abstract: The present invention provides a process for making an enzyme-modified cheese flavoring in which treatment of a composition containing dairy proteins that include whey proteins with a proteolytic enzyme occurs prior to any heating step, and in which the treatment is of short duration. The process includes incubating a dairy mixture containing the dairy proteins at a temperature and for a period of time that are sufficient to partially hydrolyze the proteins. The invention additionally provides an enzyme-modified cheese including partially proteolyzed dairy proteins wherein the partially proteolyzed dairy proteins contain partially proteolyzed whey proteins. The enzyme-modified cheese originates from any of a broad range of dairy liquids that contain dairy proteins. In important embodiments, the enzyme-modified cheese is made by the process of the invention.

Abstract: A food or pharmaceutical composition including a liquid composition comprising the liquid fermentation broth product of a biologically active substance, in a carbohydrate medium other than dairy whey wherein said liquid fermentation broth product has not been subject to any concentrating or drying steps prior to introduction of the broth product into said food or pharmaceutical composition is provided.

Abstract: The invention relates to a plated frozen meal comprising a plate, a first group of individually frozen predominantly meat-based ingredients positioned on the plate, a second group of individually frozen predominantly carbohydrate-based or predominantly vegetable-based ingredients positioned on the plate, and at least one pellet of frozen sauce. The at least one pellet of frozen sauce is positioned such that when it thaws it facilitates the thawing or heating of at least one of the first or second groups of ingredients. This invention is also directed to a method of increasing the rate of thawing or heating of a frozen plated meal.

Abstract: The present invention relates to the production of chocolates and compound coatings having a unique texture and mouthfeel while being eaten. The chocolates and compound coatings include hydrocolloids.

Abstract: A cellulose-hydrate-based food casing impregnated on its inside with liquid smoke which has a pH of about 2 to less than 4 and additionally contains a viscosity-increasing compound, an emulsifier and a triglyceride or lecithin.

Abstract: Food packaging with a removable prize therein. Prizes are located between a first surface of a first sheet of plastic and a first surface of a second sheet of plastic via adhesive. Food is placed on a second, opposite surface of the first plastic sheet and the first surface of the second sheet. The food is covered either by using a second sheet that is wide enough that it is folded over the food and sealed, or a separate third sheet is placed over the food and sealed to the second and first sheets. In this way, the prize is prevented from commingling with the food, and the prize can be attached to the food packaging per se.

Abstract: The disclosed invention provides a microwavable package for a food product. The package comprises a base with an active microwave energy heating element to support the food product. The active microwave heating element comprises energy collecting resonant loops, tuned structures, and transmission lines to collect incident microwave energy and redirect it to other parts of the food product. The microwave package also includes a cover comprising a microwave energy interactive layer including one or more apertures within the cover. The apertures promote localized fields to promote browning of the food product in the local areas around the apertures. The cover may also comprise a susceptor layer that is heated in localized areas around the apertures due to the fields promoted by the apertures and impingement by incident microwaves energy through the apertures, thereby providing localized browning of the food product.

Abstract: Apparatus (10) and methods are disclosed where plastic extrudable food product is provided such as by an extruder or pump and is combined with another food product without intermixing to form a complexly patterned food product, such as by a pattern forming die (20). The cross-sectional area of the patterned food product is reduced from an inlet end (34) to an outlet end (36) by a factor of 4:1 to as much as 50:1 at an average convergence angle of 5 to 65° while maintaining the cross-sectional pattern to form a reduced cross-sectional patterned food product, and then is extruded through a die port having an opening equal to the reduced cross-sectional area to form a complexly patterned extrudate.

Abstract: A process for preparing fruits of plants in the family Solanaceae, genus capsicum is provided. The process includes the step of boiling the fruits for a period of less than 300 seconds in a solution of a sweetener such as sugar in an acideous liquid such as vinegar.

Abstract: Coated confectionery is formed by introducing pieces of a first confectionery material into recesses in one of a pair of cooled rollers. These are carried around by contra-rotation of the rollers to a nip where chocolate or the like is introduced into the nip to coat the pieces so as to produce the coated confectionery.

Abstract: A product with a striped coating, method for making, and an apparatus for applying a coating to a confectionery to produce a confectionary with a striped appearing coating. The striped appearing coating preferably includes more than one type of chocolate, preferably two types of chocolate. Advantageously, the striped appearing coating is formed from two layers of chocolate, a foundation chocolate layer and a striped chocolate layer, thus giving the striped appearing chocolate coating a three dimensional texture.

Abstract: A product with a striped coating, method for making, and an apparatus for applying a coating to a confectionery to produce a confectionary with a striped appearing coating. The striped appearing coating preferably includes more than one type of chocolate, preferably two types of chocolate. Advantageously, the striped appearing coating is formed from two layers of chocolate, a foundation chocolate layer and a striped chocolate layer, thus giving the striped appearing chocolate coating a three dimensional texture.

Abstract: The present invention provides a stable preservation method of a powdered soft drink preparation, which includes adding 0.2 to 1.0% by weight of a calcium oxide and 0.02 to 2.0% by weight of a particulate silicon dioxide in the powdered soft drink preparation containing a carbohydrate and a sour agent as a main component. The powdered soft drink preparation of the present invention maintains the original powder state, color and taste, which are obtained immediately after the production, for a long period of time without causing comparatively rapid coagulation of powders, discoloration and change in taste at the time of preservation.

Abstract: A method is disclosed to enhance the softness of baked products and retard staling. The method is based on the use of structurally expanded cellulose which is incorporated into the dough during mixing to increase the water absorption of the dough without imparting stickiness. The ability to supersaturate the dough without detrimental impact on processability results in softer character and better grain of the baked product. These properties are maintained over time resulting in reduced staling and superior quality of sliced product.

Abstract: A method of making a dairy product includes the steps of separating substantially pure dairy water from a dairy staring material, making the dairy water into a dairy product for consumption, the dairy product being substantially pure and free of impurities from the dairy starting material and packaging the dairy product.

Abstract: The present invention relates to a process for refining high acidity vegetable oil that includes a) stripping an optionally bleached vegetable oil with steam at a temperature of 120 to 250° C. and a pressure of 0.7 to 5 mbar for 1 to 60 minutes; b) treating the oil obtained with lye; c) bleaching the oil obtained; d) stripping the bleached oil obtained with steam at a temperature of 120-250° C. and a pressure of 0.7-5 mbar for 5-120 minutes. The resulting oil is bland, transparent and colorless. Refined olive oil is suited for blending with a virgin olive oil or to be used as an ingredient for the preparation of spreads, mayonnaises, tomato sauces and salad oils.

Abstract: The present invention relates to the discovery that hop extract is useful as an antibacterial agent against the dangerous pathogens Clostridium botulinum, Clostridium difficile, and Helicobacter pylori at levels below that at which a flavor from the acids contained therein is objectionable. More specifically, a process and associated product is described herein, comprising applying a solution of hop extract to a food, beverage or other medium so that the final concentration of hop ingredients is about 1 ppm or higher in order to inhibit the growth of Clostridium botulinum, Clostridium difficile, and/or Helicobacter pylori.

Abstract: A method of shaping a spherical body composed of an outer covering layer and an inner filling, comprising a holder frame, a rotary wheel rotated forwards and backwards alternatively in the holder frame, and triangular cutter members coupled to the rotary wheel and arranged in sliding contact with each other and moved with the rotary wheel between a first position to form a center opening for the passing of a continuously fed cylindrical body consisting of dough crust and a filling, and a second position to shape a spherical body consisting of dough crust and a filling from the continuously fed cylindrical body.

Abstract: Described is a process for augmenting, enhancing or imparting an aroma or taste of or to a consumable material which can be: (i) a calcium supplement; (ii) a foodstuff; (iii) a beverage; (iv) a chewing gum; (v) a toothpaste; or (vi) an oral care such as a mouthwash, by adding to the consumable material a tastand composition obtained from Saccharum officinarum leaves (sugarcane leaves) by means of carrying out a sequence of physical separation unit operations on a plurality of such leaves, macerates thereof or mixtures of leaves and macerates thereof, whereby the tastand composition is separated and isolated from the remainder of the plurality of leaves, macerates thereof or mixtures of leaves and macerates thereof; and then spray-drying or freeze-drying the resulting product.

Abstract: A powdered sweetener composition for animal feed containing an intimate mixture with a substantially uniform, non-statistical sweetener/potentiator distribution that is substantially constant in all particles. The particle size of the composition is particularly from 10 to 100 &mgr;m, and has a Gaussian distribution. The composition is particularly useful for preparing feed for young animals, e.g. piglets, in which case the sweetener is a saccharine salt and the potentiator is neohesperidine dihydrochalcone (NHDC), thaumatin or glycyrrhizin.

Abstract: Methods for making improved flavor potato products by using raw potato stock as a starting material to form a sheetable dough. The methods comprise controlled processing steps that result in a potato gel suitable for sheeting or extruding. Use of raw potato stock greatly enhances the potato flavor of the snack product ultimately produced.

Abstract: The present invention relates to a novel method of making a non-liquid fruit product (fruit chip) which has a natural fruit flavor and which can be formed in desired individual or discrete configurations and sizes.

Abstract: A method of microdissection which involves forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes a selectively activatable adhesive layer which provides, for example, chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated, the transfer surface and tissue sample are separated.

Abstract: A masking member including a substance provided to be deposited onto a surface in order to mask the latter, and protect it from outer affection, the substance being provided to be deposited as an easily releasable film on said surface by being brushed against said surface.