Patents Issued in March 20, 2003
  • STAPHYLOCOCCUS AUREUS POLYNUCLEOTIDES AND SEQUENCES
    Publication number: 20030054436
    Abstract: The present invention provides polynucleotide sequences of the genome of Staphylococcus aureus, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.
    Type: Application
    Filed: January 3, 1997
    Publication date: March 20, 2003
    Inventors: CHARLES A. KUNSCH, GIL A. CHOI, STEVEN C. BARASH, PATRICK J. DILLON, MICHAEL R. FANNON, CRAIG A. ROSEN
  • VERTEBRATE EMBRYONIC PATTERN-INDUCING PROTEINS AND USES RELATED THERETO
    Publication number: 20030054437
    Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
    Type: Application
    Filed: October 20, 1997
    Publication date: March 20, 2003
    Inventors: PHILIP w INGham, ANDREW P. MCMAHON, CLIFFORD J TABIN
  • Androgen receptor complex-associated protein
    Publication number: 20030054438
    Abstract: The invention relates to new proteins that bind to and aide the transactivation activity of androgen receptors, and nucleic acids encoding them.
    Type: Application
    Filed: February 12, 2001
    Publication date: March 20, 2003
    Inventor: Tai-Jay Chang
  • Truncated soluble tumor necrosis factor type-I and type-II receptors
    Publication number: 20030054439
    Abstract: Disclosed are novel proteins, referred to as tumor necrosis factor binding proteins, that modulate the activity of tumor necrosis factor. Also disclosed are processes for obtaining the tumor necrosis binding proteins by recombinant genetic engineering techniques.
    Type: Application
    Filed: June 15, 2001
    Publication date: March 20, 2003
    Applicant: Amgen Inc.
    Inventors: Eric F. Fisher, Carl K. Edwards, Gary L. Kieft
  • Novel proteins with integrin-like activity
    Publication number: 20030054440
    Abstract: The invention relates to novel proteins with novel integrin and I domain activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of integrin related disorders.
    Type: Application
    Filed: July 9, 2001
    Publication date: March 20, 2003
    Inventors: Stephen Mayo, Julia Shifman, Motomu Shimaoka, Timothy Springer
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054441
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 12, 2001
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Avi Ashkenazi, David Botstein, Luc Desnoyers, Dan L. Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary E. Gerritsen, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hillan, Ivar J. Kljavin, Jennie P. Mather, James Pan, Nicholas F. Paoni, Margaret Ann Roy, Timothy A. Stewart, Daniel Tumas, P. Mickey William, William I. Wood
  • IL-17 homologous polypeptides and therapeutic uses thereof
    Publication number: 20030054442
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 18, 2001
    Publication date: March 20, 2003
    Applicant: GENENTECH, INC.
    Inventors: Jian Chen, Ellen Filvaroff, Sherman Fong, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin Gurney, Hanzhong Li, Kenneth Hillan, Daniel Tumas, Menno VanLookeren, Richard Vandlen, Colin K. Watanabe, P. Mickey Williams, William I. Wood, Daniel Yansura
  • 90 human secreted proteins
    Publication number: 20030054443
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
    Type: Application
    Filed: October 4, 2001
    Publication date: March 20, 2003
    Inventors: Steven M. Ruben, Daniel R. Soppet, Reinhard Ebner, Henrik S. Olsen, Paul E. Young, John M. Greene, Ann M. Ferrie, Guo-Liang Yu, Jian Ni, Craig A. Rosen, Laurie A. Brewer, Fouad Janat, Charles E. Birse
  • Novel human G-protein coupled receptor, HGPRBMY8, expressed highly in brain
    Publication number: 20030054444
    Abstract: The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, neurological conditions, and diseases or disorders related to the brain are illustrated.
    Type: Application
    Filed: November 14, 2001
    Publication date: March 20, 2003
    Inventors: Peter Battaglino, John N. Feder, Gabe Mintier, Thomas C. Nelson, Chandra S. Ramanathan, Ryan Westphal, Angela Cacace, Lauren Barber, Donald R. Hawken, Michael G. Kornacker
  • Polynucleotide encoding a novel human serpin secreted from lymphoid cells, LSI-01
    Publication number: 20030054445
    Abstract: The present invention provides novel polynucleotides encoding LSI-01 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LSI-01 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: November 14, 2001
    Publication date: March 20, 2003
    Inventors: Jian Chen, John N. Feder, Thomas Nelson, Steven Seiler, Donna A. Bassolino, Daniel L. Cheney, Franck Duclos
  • Novel retina-specific human proteins C7orf9, C12orf7, MPP4 and F379
    Publication number: 20030054446
    Abstract: The present invention relates to the novel human retina-specific proteins called C7orf9, C12orf7, MPP4 and F379, and isolated nucleic acid molecules encoding said proteins. Also provided are vectors, host cells, antibodies and recombinant methods for producing these human proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating macular degeneration, e.g. AMD.
    Type: Application
    Filed: November 29, 2001
    Publication date: March 20, 2003
    Inventors: Bernard H. F. Weber, Heidi Stoehr
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054447
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: December 27, 2001
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: David Botstein, Luc Desnoyers, Napoleone Ferrara, Sherman Fong, Wei-Qiang Gao, Audrey Goddard, Austin L. Gurney, James Pan, Margaret Ann Roy, Timothy A. Stewart, Daniel Tumas, Colin K. Watanabe, William I. Wood
  • T1R taste receptors and genes encoding same
    Publication number: 20030054448
    Abstract: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular taste stimulus in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
    Type: Application
    Filed: January 3, 2002
    Publication date: March 20, 2003
    Applicant: Senomyx, Inc.
    Inventors: Jon Elliot Adler, Xiaodong Li, Lena Staszewski, Shawn O'Connell, Sergey Zozulya
  • 63744, a human sugar transporter family member and uses thereof
    Publication number: 20030054449
    Abstract: The invention provides isolated nucleic acids molecules, designated 63744 nucleic acid molecules, which encode novel sugar transporter family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 63744 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 63744 gene has been introduced or disrupted. The invention still further provides isolated 63744 proteins, fusion proteins, antigenic peptides and anti-63744 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: January 31, 2002
    Publication date: March 20, 2003
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventor: Rory A.J. Curtis
  • Composition and method for reconstituting IkB kinase in yeast and methods of using same
    Publication number: 20030054450
    Abstract: The invention provides a means for reconstituting I&kgr;B kinase in yeast in order to study the structure and regulation of IKK and to produce pharmacological therapies to block IKK. This invention can be used to express an IKK complex that is biochemically identical to IKK isolated from native cells and in coupled in vitro kinase assays to screen for its upstream regulators. The IKK expressed by reconstituting the yeast can be used to screen for unknown substrates and for pharmacological therapies that block its activity. The invention could also be used to screen for compounds that enhance its activity. The IKK may also be used as a source of material for crystallization and X-ray diffraction analysis.
    Type: Application
    Filed: February 19, 2002
    Publication date: March 20, 2003
    Applicant: University of Southern California
    Inventors: Ebrahim Zandi, Beth Schomer Miller
  • Opiate receptors
    Publication number: 20030054451
    Abstract: The invention provides isolated nucleic acid molecules, host cells that contain an isolated nucleic acid molecule, and substantially pure polypeptides. For example, the invention provides isolated nucleic acid molecules that encode polypeptides having mu3 opiate receptor activity, host cells that contain an isolated nucleic acid molecule that encodes a polypeptide having mu3 opiate receptor activity, and substantially pure polypeptides that have mu3 opiate receptor activity. In addition, the invention provides methods and materials for identifying mu3 opiate receptor agonists and antagonists.
    Type: Application
    Filed: February 22, 2002
    Publication date: March 20, 2003
    Inventors: Patrick Cadet, George B. Stefano
  • Isolated human EDG-4 receptor
    Publication number: 20030054452
    Abstract: A novel, isolated EDG receptor that upon activation results in increased induction of IL-8 or NF-&kgr;B. Preferably, the EDG receptor is a human EDG-4 receptor, which has an amino acid sequence shown in FIGS. 16A and 16B, or a variant of these sequences having at least 91% sequence identity.
    Type: Application
    Filed: February 28, 2002
    Publication date: March 20, 2003
    Applicant: Allelix Biopharmaceuticals
    Inventors: Donald G. Munroe, Rajender Kamboj, Diana Peters, Fatemeh Kooshesh, Tejal B. Vyas, Ashwani K. Gupta
  • 68723, sodium/glucose cotransporter family members and uses therefor
    Publication number: 20030054453
    Abstract: The invention provides isolated nucleic acids molecules, designated 68723 nucleic acid molecules, which encode novel sodium/glucose cotransporter family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 68723 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 68723 gene has been introduced or disrupted. The invention still further provides isolated 68723 proteins, fusion proteins, antigenic peptides and anti-68723 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: April 10, 2002
    Publication date: March 20, 2003
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Rory A.J. Curtis, Hong Chen
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054454
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: June 26, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054455
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: June 28, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054456
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: June 27, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054457
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 1, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054458
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 1, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054459
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 12, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054460
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 15, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054461
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 16, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054462
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 17, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054463
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 17, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054464
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 17, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054465
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 19, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054466
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 19, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054467
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 18, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054468
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 19, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054469
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 22, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054470
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 22, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054471
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 22, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054472
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 22, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054473
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 22, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054474
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 22, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054475
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 23, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054476
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 23, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054477
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 23, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054478
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 23, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054479
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 24, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054480
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 24, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054481
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 24, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054482
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 25, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20030054483
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: July 26, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Kevin P. Baker, Jian Chen, Luc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, James Pan, Victoria Smith, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Compositions and methods for the treatment of immune related diseases
    Publication number: 20030054484
    Abstract: The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
    Type: Application
    Filed: August 5, 2002
    Publication date: March 20, 2003
    Applicant: Genentech, Inc.
    Inventors: Sherman Fong, Audrey Goddard, Paul J. Godowski, J. Christopher Grimaldi, Austin L. Gurney, Kenneth J. Hillan, Daniel Tumas, Colin K. Watanabe, William I. Wood, Zemin Zhang
  • Jelly belly genes and their uses
    Publication number: 20030054485
    Abstract: Isolated nucleotide compositions and sequences are provided for jelly belly (jeb) genes. The jeb nucleic acid compositions find use in identifying homologous or related genes; in producing compositions that modulate the expression or function of its encoded protein, Jeb; for gene therapy; mapping functional regions of the protein; and in studying associated physiological pathways. Jeb is required for visceral mesoderm migration and differentiation. Its transcription is directly regulated by Tin. jeb is required for a signal to be transduced from somatic mesoderm to visceral mesoderm. The protein encoded by jeb is secreted from somatic muscle precursors and taken up by visceral muscle precursors. The expression of jeb in neurons later in embryogenesis is indicative that Jeb signaling plays additional roles in the development of the nervous system.
    Type: Application
    Filed: August 6, 2002
    Publication date: March 20, 2003
    Inventors: Matthew Peter Scott, Joseph Benjamin Weiss