Patents Issued in April 20, 2004
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Patent number: 6723824Abstract: An optical disk substrate formed of an aromatic polycarbonate resin obtained by a reaction between an aromatic dihydroxy compound and a carbonate diester and in which the content of undissolved substances that emit light by irradiation with light having a wavelength of 380 nm and have a size of 30 &mgr;m or greater is 100 pieces or less per kg of said resin, and a molding material therefor. According to the present invention, there can be provided an optical disk substrate in which the number of white spots that occur in the passage of a long period of time is very small and the reliability of writing and reading of information is highly stable.Type: GrantFiled: June 25, 2002Date of Patent: April 20, 2004Assignee: Teijin Chemicals, Ltd.Inventors: Makoto Ishida, Tsukasa Saito
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Patent number: 6723825Abstract: The invention relates to a process for preparing a liquid melamine urea formaldehyde resin that has long term stability. The invention also relates to a liquid MUF resin with a high formaldehyde and melamine content. The invention further relates to a liquid suspension hardener including a catalyst, a thickener, a filler, and water. The invention also relates to a adhesive composition for use in wood bonding that is made by adding a hardener to the resin.Type: GrantFiled: February 25, 2003Date of Patent: April 20, 2004Assignee: Cytec Technology Corp.Inventors: Huide Dennis Zhu, William Jacobs, III, Robert G. Lees, Luis Mendonca, Roger C. Rasch
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Patent number: 6723826Abstract: An apparatus for continuously producing polybutylene terephthalate, which comprises a first reactor for reacting an aromatic dicarboxylic acid with a glycol, thereby producing an oligomer, a second reactor for polycondensating the oligomer, thereby preparing a low polymerization product, and a third reactor for further polycondensating the low polymerization product, thereby producing a high molecular weight polyester, where the second reactor is a vertical, cylindrical polymerization vessel having a plurality of concentrical partitioned reaction compartments therein, each of the reaction compartments being provided with stirring blades and a heater, and an outlet for volatile matters being provided at the upper part of the vessel. The second reactor contributes to efficient and continuous production of polybutylene terephthalate having a good quality.Type: GrantFiled: May 28, 2003Date of Patent: April 20, 2004Assignee: Hitachi, Ltd.Inventors: Shuji Yamaguchi, Hidekazu Nakamoto, Susumu Harada, Norifumi Maeda
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Patent number: 6723827Abstract: A polythioether comprising: wherein R1 is a C1-10 alkyl, —(R3Q)pR3— or C6-C20 aryl where Q is O or S, each R3 is independently C1-6 alkyl, and p is an integer between 0 and 6; R2 is C1-6 alkyloxy or C5-12 cycloalkyloxy, R4 is H, C1-6 alkyl, C1-6 alkyl alcohol and C0-6 alkyl substituted with where X is a halogen, m is an integer between 1 and 4, and n is an integer selected to yield a molecular weight for said polythioether of between 1000 and 10,000 Daltons.Type: GrantFiled: February 20, 2003Date of Patent: April 20, 2004Assignee: PBT Brands, Inc.Inventors: Jonathan D. Zook, David W. Jordan, Dean M. Willard, George Jones, Michael Cosman
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Patent number: 6723828Abstract: The invention provides conjugated polymers that have good solubility and semiconductivity, and that display high photoluminescent and electroluminescent efficiency.Type: GrantFiled: May 23, 2001Date of Patent: April 20, 2004Assignee: SRI InternationalInventor: Qibing Pei
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Patent number: 6723829Abstract: Polypropylene heterophasic copolymers with good flow and impact properties are made by visbreaking a starting polypropylene heterophasic copolymer of which the amorphous rubber has an intrinsic viscosity of 2 dl/g or more and the ethylene content in the amorphous rubber, determined as C2 of AM, is from 20 wt-% to 45 wt-%.Type: GrantFiled: June 10, 2002Date of Patent: April 20, 2004Assignee: Borealis Technology OyInventors: Bo Malm, Pirjo Jääskeläinen, Torvald Vestberg
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Patent number: 6723830Abstract: Peptides which are peptide derivatives of the &agr;D region of a protein kinase can modulate the activity of protein kinases. The activity of a protein kinase in a subject can be modulated by administering one or more of these peptides.Type: GrantFiled: January 8, 2002Date of Patent: April 20, 2004Assignees: Children's Medical Center Corporation, Yissum Research and DevelopmentInventor: Shmuel A. Ben-Sasson
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Patent number: 6723831Abstract: Polyamide conjugates comprising either (a) a xenoantigenic group; or (b) a biologically active group and a macromolecular, macro- or microscopic entity; bound to a polyamide backbone, processes for their preparation and the use of these conjugates in therapeutic compositions.Type: GrantFiled: April 16, 2002Date of Patent: April 20, 2004Assignee: Novartis AGInventors: Rudolf Duthaler, Andreas Katopodis, Willy Kinzy, Reinhold Öhrlein, Gebhard Thoma
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Patent number: 6723832Abstract: The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.Type: GrantFiled: October 2, 1998Date of Patent: April 20, 2004Assignees: Ludwig Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, Academisch Ziekenhuis Leiden, Cornell Research FoundationInventors: Alexander Knuth, Elke Jäger, Yao-tseng Chen, Matthew Scanlan, Ali Gure, Gerd Ritter, Lloyd J. Old, Jan W. Drijfhout
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Patent number: 6723833Abstract: The present invention relates to a method for adjusting the affinity of a polypeptide to a target molecule by a combination of steps, including: (1) the identification of aspartyl residues which are prone to isomerization; (2) the substitution of alternative residues and screening the resulting mutants for affinity against the target molecule. In a preferred embodiment, the method of substituting residues is affinity maturation with phage display (AMPD). In a further preferred embodiment the polypeptide is an antibody and the target molecule is an antigen. In a further preferred embodiment, the antibody is anti-IgE and the target molecule is IgE. In another embodiment, the invention relates to an anti-IgE antibody having improved affinity to IgE.Type: GrantFiled: November 17, 2000Date of Patent: April 20, 2004Assignee: Genentech, Inc.Inventors: Henry B. Lowman, Leonard G. Presta, Paula M. Jardieu, John Lowe
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Patent number: 6723834Abstract: A reactive dye compound comprising: (a) at least one chromophore moiety; (b) at least one nitrogen-containing heterocycle (c) a linking group to link each chromophore moiety to each nitrogen-containing heterocycle; characterized in that at least one nitrogen-containing heterocycle is substituted with at least one Y group wherein Y is derived from a hydrated aldehyde, a hydrated ketone, a hydrated alpha-hydroxy ketone, or the hydrated form of formic acid and linked via one of its oxygen atoms to the nitrogen-containing heterocycle thereby forming a hemiacetal.Type: GrantFiled: March 27, 2002Date of Patent: April 20, 2004Assignee: North Carolina State UniversityInventors: Peter Jeffrey Broadbent, Dong Wei He, David Malcolm Lewis, Gilles Yves Marie Fernand Ganain, Taher Iqbal Yousaf
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Patent number: 6723835Abstract: Compositions containing a solvent and at least one compound of Formula (1) in which: R1 represents H, an optionally substituted C1-8carbyl derived group, or a group of Formula A: in which c is from 2 to 6; R3 represents H or optionally substituted C1-8carbyl derived group; R4 and R5 independently represent an optional substituent; R2 represents an optionally substituted C1-8carbyl derived group; X, Y and Z independently represent H or an optional substituent; M represents H or a cation; and m and n independently represent 0, 1 or 2, are useful as colorants for color filters for displays. Compounds of Formula (1) wherein at least one of R1, R2, X, Y or Z, represent SO3M or PO3M2 are also provided.Type: GrantFiled: March 20, 2002Date of Patent: April 20, 2004Assignee: Avecia LimitedInventors: Christine Millard, Neil Anthony Tallant
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Patent number: 6723836Abstract: To provide low odor polyoxyalkylene polyol, a process for producing the same, and a low odor urethane prepolymer and a low odor urethane composition using the same as a raw material. The low odor polyoxyalkylene polyol comprising polyoxyalkylene polyol with amine added thereto, the amine having at least one amino group represented by the following formula (1): is provided, wherein R1, R2 and R3 independently represent hydrogen atom or an organic group which may contain a hetero atom in which an atom bonded to nitrogen atom is carbon atom.Type: GrantFiled: April 20, 2000Date of Patent: April 20, 2004Assignee: The Yokohama Rubber Co., Ltd.Inventors: Kiminori Araki, Kazunori Ishikawa
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Patent number: 6723837Abstract: This invention relates to the field of biotechnology, particularly as it pertains to a nucleic acid molecule encoding a protein associated with sterol and phytosterol synthesis and metabolism. The invention also relates to methods of detection using the nucleic acid molecule, or the encoded protein as a probe or in a microarray.Type: GrantFiled: July 11, 2000Date of Patent: April 20, 2004Assignee: Monsanto Technology LLCInventors: Balasulojini Karunanandaa, Jaehyuk Yu, Ganesh Kishore
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Patent number: 6723838Abstract: The present invention features molecules that relate to SYNGAP (Synaptic GTPase Activating Protein), an excitatory synapse protein that has been found to bind synaptic proteins and modulate signal transduction. In one aspect, the invention provides isolated polynucleotides that encode SYNGAP or fragments or derivatives thereof. Further provided are SYNGAP or SYNGAP-related polypeptides encoded by the polynucleotides. In another aspect, the invention provides immunological molocules that are capable of binding the polypetides. Additionally provided are methods for using the molocules of this invention, e.g., to treat or prevent a disorder mediated by SYNGAP. The invention also provides screening assays for detecting compounds useful in the diagnosis or treatment of disorders impacted by SYNGAP.Type: GrantFiled: April 19, 1999Date of Patent: April 20, 2004Assignee: Johns Hopkins UniversityInventors: Richard L. Huganir, Jee Hae Kim
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Patent number: 6723839Abstract: A novel ACC synthase gene in geranium PHSacc-25. PHSacc-25 was identified by amplifying isolated mRNA using polymerase chain reaction, the resulting cDNAs were cloned into a plasmid, positive clones were isolated, and the cDNA insert was partially sequenced. A portion of the DNA sequence encoding for the enzyme ACC synthase in geranium plants (specifically from Pelargonium hortorum cv Sincerity) was identified. The cDNA sequence corresponds to a gene which may be important in the control of ethylene production.Type: GrantFiled: October 12, 2001Date of Patent: April 20, 2004Assignee: Colorado State University through its agent Colorado State University Research FoundationInventor: Rajinder S. Ranu
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Patent number: 6723840Abstract: The invention provides isolated nucleic acid and amino acid sequences of TL-&ggr;, antibodies to TL-&ggr;, methods of screening for TL-&ggr; modulators using biologically active TL-&ggr;, and kits for screening for TL-&ggr; modulators.Type: GrantFiled: November 28, 2000Date of Patent: April 20, 2004Assignee: The Regents of the University of CaliforniaInventors: Roman Sakowicz, Lawrence S. B. Goldstein
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Patent number: 6723841Abstract: The present invention provides isolated nucleic acid molecules encoding CRF2 receptors, recombinant expression vectors and host cells suitable for expressing such receptors, as well as compositions and methods which utilize such receptors.Type: GrantFiled: June 13, 2001Date of Patent: April 20, 2004Assignee: Neurocrine Biosciences Inc.Inventors: Timothy W. Lovenberg, Tilman Oltersdorf, Chen Wang Liaw, Dimitri E. Grigoriadis, Derek T. Chalmers, Errol B. DeSouza
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Patent number: 6723843Abstract: The invention provides a system for solid-phase synthesis of oligosaccharides, based on the discovery that a 2-substituted-1,3-dioxocycloalkyl linker group of general formula (I) can be used to couple saccharide groups of both the O-glycoside and N-glycoside type to a polymer support. The invention provides reagents, reagent kits and methods for solid-phase oligosaccharide synthesis.Type: GrantFiled: August 30, 2002Date of Patent: April 20, 2004Assignee: Alchemia PTY LTDInventors: Istvan Toth, Gyula Dekany, Barry Kellam
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Patent number: 6723844Abstract: The present invention provides a process for the synthesis of K-252a and intermediates useful in the process.Type: GrantFiled: February 27, 2003Date of Patent: April 20, 2004Assignee: Abbott LaboratoriesInventors: Navayath Shobana, John C. Strong, Mark W. Tubergen, Russell A. Brierley
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Patent number: 6723845Abstract: Low-hygroscopic anhydrous mirtazapine crystals having a hygroscopic degree of not more than 0.6% by weight when the crystals are stored in the air having a relative humidity of 75% at 25° C. under atmospheric pressure for 500 hours; a process for preparing anhydrous mirtazapine crystals having a hygroscopic degree of not more than 0.6% by weight when the crystals are stored in the air having a relative humidity of 75% at 25° C. under atmospheric pressure for 500 hours, comprising drying crystals of mirtazapine hydrate; a crystal of a mirtazapine hydrate represented by the formula (I): wherein n is an integer of 1 to 5; and a process for preparing crystals of a mirtazapine hydrate, comprising crystallizing a crude mirtazapine using a water-soluble organic solvent and water. The anhydrous mirtazapine crystals can be suitably used, for instance, as an antidepressant.Type: GrantFiled: January 7, 2003Date of Patent: April 20, 2004Assignee: Sumika Fine Chemicals Co., Ltd.Inventors: Eiichi Iishi, Yoshiyuki Imamiya
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Patent number: 6723846Abstract: The present invention relates to compounds having formula (1): wherein each R1 represents, independently, a linear C1-C4-alkylene residue which is unsubstituted or substituted by hydroxy, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-hydroxy- or alkoxy-alkoxy, —OCOM, —OCOC1-C4-alkyl, or an amino acid residue from which a hydrogen atom on the amino group has been removed; each R2 represents, independently, a linear C1-C4-alkylene residue which is unsubstituted or substituted by hydroxy, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-hydroxy- or alkoxy-alkoxy, —OCOM, —OCOC1-C4-alkyl, —CO2M, CO2C1-C4-alkyl SO3M or phenoxy which is unsubstituted or substituted by halogen, C1-C4-alkyl or C1-C4-alkoxy, —CO2M or CO2C1-C4-alkyl, NH3 or mono- or disubstituted amino; or phenyl which is unsubstituted or substituted by 1 to 3 SO3M, SO2NHC1-C4-alkyl, —SO2NH2, —CO2M, —CO2M, —CO2C1-C4-alkyl, —CONH2, —CONHC1-C4-alkyl, —NHCOC1-C4-alkyl or mono- or disubstituted amino groups;Type: GrantFiled: March 6, 2002Date of Patent: April 20, 2004Assignee: Ciba Specialty Chemicals CorporationInventors: Georges Metzger, Serge Hauger, Fabienne Cuesta, Christophe Bulliard, Peter Rohringer, Marc Roger Grienenberger
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Patent number: 6723847Abstract: The present invention is directed to novel spiro compounds useful as neuropeptide Y receptor antagonists.Type: GrantFiled: June 4, 2003Date of Patent: April 20, 2004Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Takehiro Fukami, Akio Kanatani, Akane Ishihara, Yasuyuki Ishii, Toshiyuki Takahashi, Yuji Haga, Toshihiro Sakamoto, Takahiro Itoh
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Patent number: 6723848Abstract: Process for the preparation of benzo-fused heterocycles of general formula I: in which X, R1, R2, R3, R4, R5 and n are as defined in claim 1, by reacting tetrahydrobenzo-fused heterocycles of formula II: in which X, R1, R2, R3, R4, R5, n and Ac are as defined in claim 1, with a catalytic amount of a noble metal catalyst in the presence of a hydrogen acceptor and then deacylating the acylated amino group by the addition of an amine.Type: GrantFiled: October 9, 2002Date of Patent: April 20, 2004Assignee: Merck Patent Gesellschaft mit Beschränkter HaftungInventors: Frank-Hardi Wartenberg, Thomas Koppe, Walter Wetzel, Markus Wydra, Achim Benz
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Patent number: 6723849Abstract: A process for synthesizing highly lipophilic derivatives of camptothecin. The process includes reacting dissolved, underivatized camptothecin with an aldehyde in a modified Minisci-type alkylation reaction to produce 7-substituted derivatives of camptothecin.Type: GrantFiled: July 25, 2003Date of Patent: April 20, 2004Assignee: BioNumerik Pharmaceuticals, Inc.Inventors: Kesavaram Narkunan, Harry Kochat, Xinghai Chen
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Patent number: 6723850Abstract: The present invention refers to a process for the preparation of (1H)-benzo[c]quinolizin-3-ones derivatives of general formula (I) which involves only three steps and the use, as starting products, of commercially available, or easily preparable, compounds. The compounds of formula (I) are useful as inhibitors of 5&agr;-reductases.Type: GrantFiled: May 25, 2001Date of Patent: April 20, 2004Assignee: Applied Research Systems ARS Holding N.V.Inventors: Antonio Guarna, Mario Serio, Ernesto Occhiato
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Patent number: 6723851Abstract: A novel chemiluminescent compound is provided. In one embodiment, the novel compound is employed in an assay to detect analytes. The assay to detect analytes includes the steps of binding the novel compound to the analyte and detecting the novel compound.Type: GrantFiled: October 31, 2001Date of Patent: April 20, 2004Assignee: Quest Diagnostics Investment IncorporatedInventors: Phillip Miller, Martha Garrity
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Patent number: 6723852Abstract: The method for obtaining derivatives of [[(pyridil substituted)methyl]thio]benzomidazol (I), where each of R1, R3 and R4, independently of each other, is hydrogen, an alkyl, alkoxy or fluorinated alkoxy of 1 to 6 carbon atoms, and R2 is nitro, halogen, alkoxy or halogenated alkoxy of 1 to 6 carbon atoms, or a group —OR—(CH2)n—OR8, where n is an integer between 1 and 6 and R8 represents hydrogen or an alkyl group with 1 to 6 carbon atoms, which involves (a) reacting an N-oxide of a methylpyridine with an anhydride of activated carboxylic acid or of sulfonic acid, and (b) reacting the intermediate formed in stage (a) with a corresponding mercaptobenzomidazol. The compounds (I) are useful in the synthesis of derivatives of [[(pyridil substituted)methyl]sulfinyl]benzomidazol, such as omeprazol, lansoprazol, rabeprazol or pantoprazol.Type: GrantFiled: August 20, 2002Date of Patent: April 20, 2004Assignee: Esteve Quimica, S.A.Inventor: Ramon Berenguer Maimo
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Patent number: 6723853Abstract: A method of synthesizing a compound having the formula: from a compound having the formula: wherein R1 is hydrogen, fluorine, chlorine or SiR5R6R7, wherein R5, R6, and R7 are independently the same or different an alkyl group or an aryl group, R2 is an alkyl group, R3 is a protecting group, R4 is an alkyl group, an allyl group, a propargyl group —CO2H, or a benzyl group, R8 is —CO2R10, wherein R10 is an alkyl group or an aryl group, X1 is OH and X2 is H, includes the step of exposing compound (III) to at least one of an organic acid or an inorganic acid. A compound has the general formula (III).Type: GrantFiled: August 27, 2001Date of Patent: April 20, 2004Assignee: University of PittsburghInventors: Dennis P. Curran, Ana E. Gabarda
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Patent number: 6723854Abstract: The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.Type: GrantFiled: February 25, 2003Date of Patent: April 20, 2004Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: Samuel J. Danishefsky, Peter Bertinato, Dai-Shi Su, Dang Fang Meng, Ting-Chao Chou, Ted Kamenecka, Erik J Sorensen, Aaron Balog, Kenneth A. Savin
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Patent number: 6723855Abstract: A process for synthesizing leflunomide from 5-methylisoxazole-4-carboxylic acid and 4-trifluoromethylaniline is provided in which the carboxylic acid group of 5-methylisoxazole-4-carboxylic acid is chlorinated, forming 5-methylisoxazole-4-carboxylic acid chloride. The acid chloride is then reacted without intermediate distillation with 4-trifluoromethylaniline in the presence of an alkali metal or alkaline-earth metal bicarbonate acid scavenger.Type: GrantFiled: February 8, 2001Date of Patent: April 20, 2004Assignee: Teva Pharmaceutical Industries Ltd.Inventors: Ilya Avrutov, Neomi Gershon, Anita Liberman
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Patent number: 6723856Abstract: The present invention provides a process for preparing of 2-acetyl-1-pyrroline, the principle aroma component of basmati and other varieties of scented rice, and also of processed cereal and grain products, said flavor chemical is of great value, in the art of application of flavor to foodstuffs like rice and bakery products.Type: GrantFiled: March 28, 2003Date of Patent: April 20, 2004Assignee: Council of Scientific and Industrial ResearchInventors: Pullabhatia Srinivas, Kambadoor Nagarajarao Gurudutt
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Patent number: 6723857Abstract: The present invention provides a process for the preparation of a bicyclic aminoalcohol which comprises reacting a starting compound, nopinone (I), with XCH2COOR1 wherein X is halogen, and R1 is alkyl, in the presence of an additive and a base to produce a compound (II), converting it to oxime derivative (III), and reducing it with an aluminum hydride.Type: GrantFiled: January 2, 2002Date of Patent: April 20, 2004Assignee: Shionogi & Co., Ltd.Inventors: Tsunetoshi Honma, Hiramatsu Yoshiharu, Susumu Mitsumori
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Patent number: 6723858Abstract: The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found below in a dosage sufficient to inhibit cell mitosis. The application discloses novel compounds used in the methods.Type: GrantFiled: February 21, 2002Date of Patent: April 20, 2004Assignee: The Children's Medical Center CorporationInventors: Robert John D'Amato, Moses Judah Folkman
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Patent number: 6723859Abstract: Novel chromene compounds having various substituents to exhibit a high color-developing sensitivity and a high density even when dispersed in a high-molecular matrix, and exhibiting a large fading rate, less color when deteriorated, and excellent light resistance in the photochromic properties; photochromic materials containing the chromene compounds; and use thereof.Type: GrantFiled: October 15, 2001Date of Patent: April 20, 2004Assignee: Tokuyama CorporationInventors: Yuichiro Kawabata, Yasuko Takeda, Junji Momoda, Hironobu Nagoh, Shinobu Izumi
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Patent number: 6723860Abstract: The present invention provides a novel 7a-alkoxy-4H-pyrano-[3,2-d]-oxazol-2(3H)-one represented by the formula (I): wherein R1 and R2 each represent a hydrogen atom, an alkyl group, an alkenyl group, an aryl group or an aralkyl group; R3 represents an alkyl group, a cyclo-alkyl group, an alkenyl group, an aryl group or an aralkyl group, provided that a 2-alkenyl group is excluded from the alkenyl group of R3; and R4 represents an alkyl group, an aryl group, an alkoxycarbonyl group or a cyano group, and a process for producing the same which comprises reacting 5-alkoxy-2(3H)-oxazolone with an &agr;,&bgr;-unsaturated ketone in the presence of a Lewis acid in a solvent.Type: GrantFiled: November 16, 2001Date of Patent: April 20, 2004Assignee: UBE Industries, Ltd.Inventors: Hiroyuki Miyata, Takashi Honma, Yasuhito Yamamoto, Kikuo Ataka
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Patent number: 6723861Abstract: Process for manufacturing oxirane by reaction of an olefin with a peroxide compound in the presence of a catalyst and a solvent in at least two reactors arranged in series, each of which contains a portion of the catalyst, according to which two epoxidation reactions are carried out in series including intermediate distillation, to minimize the formation of by-products.Type: GrantFiled: December 19, 2002Date of Patent: April 20, 2004Assignee: Solvay (Societe Anonyme)Inventor: Dominique Balthasart
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Patent number: 6723862Abstract: The present invention generally relates to a process for the preparation of branched fatty acids from straight chain unsaturated fatty acid feedstocks with a strongly acidic and hydrothermally stable mesoporous aluminosilicate and/or aluminophosphate catalyst materials having mesopores of 15-500 Å and contain primary and secondary nanosized zeolite structural units in the walls that separate mesopores.Type: GrantFiled: March 18, 2003Date of Patent: April 20, 2004Assignee: Akzo Nobel N.V.Inventors: Zhang Shuguang, Zhang Zongchao
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Patent number: 6723863Abstract: A process of producing a light-colored, high-monoester mixture from a polyol and an oil is provided wherein the process eliminates the use of organic solvents, multiple water washings and/or molecular distillation. The reactants, a polyol and an oil, described herein, condense in the presence of a catalyst, described herein, at a temperature range from about 180° C. to about 280° C. under an inert atmosphere or the vapor pressure of the polyol with a pressure of about 0 to about 500 psig to yield a monoester mixture possessing a desirable monoester composition and color. The present process yields a final product similar to that of processes which require the use of solvents, multiple water washings and/or molecular distillation.Type: GrantFiled: August 7, 2002Date of Patent: April 20, 2004Assignee: Archer-Daniels-Midland CompanyInventors: Inmok Lee, George Poppe
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Patent number: 6723864Abstract: Siloxane bischloroformates are prepared in a continuous process by phosgenating siloxane bisphenols in a flow reactor using a substantial excess of phosgene and sodium hydroxide. While very high levels (>95%) of conversion of the siloxane bisphenol to the corresponding siloxane bischloroformate are achieved using a flow reactor according to the method of the invention, only more modest conversion (˜90%) of the siloxane bisphenol to the corresponding siloxane bischloroformate is attained when analogous batch processes are employed. The process holds promise for use in the manufacture of silicone-containing copolycarbonates which requires high purity siloxane bischloroformate intermediates.Type: GrantFiled: August 16, 2002Date of Patent: April 20, 2004Assignee: General Electric CompanyInventors: James Manio Silva, David Michel Dardaris, Gary Charles Davis
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Patent number: 6723865Abstract: Aromatic silane compounds containing at least an aromatic ring bound directly to the silicon atom, wherein the aromatic ring has at least one substituent located in the ortho position selected from C1-10 hydrocarbon groups, are useful as electron donors in olefin polymerization catalysts for the production of polyolefins having a stereoblock content of from about 7 to about 25%.Type: GrantFiled: April 4, 2002Date of Patent: April 20, 2004Assignee: Basell Poliolefine Italia S.p.A.Inventors: Eric J. Evain, Constantine A. Stewart
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Patent number: 6723866Abstract: The invention relates to liquid-crystalline compounds of the formula I in which R1, A1, A2, Z1, Z2, a, b, L1, L2 and L3 are as defined in claim 1, and to liquid-crystalline media comprising at least compound of the formula I and to electro-optical displays containing a liquid-crystalline medium of this type.Type: GrantFiled: July 25, 2002Date of Patent: April 20, 2004Assignee: Merck Patent Gesellschaft mit Beschränkter HaftungInventors: Peer Kirsch, Michael Heckmeier, Joachim Krause, Marc Lenges, Gerald Unger
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Patent number: 6723867Abstract: Branched, substantially unsaturated fatty alcohol sulfates are produced by a process which comprises the steps of: (a) dimerizing unsaturated C16-22 fatty acid to form a dimer fraction and a monomer fraction comprised of branched, substantially unsaturated fatty acids and straight chain saturated fatty acids, (b) removing the monomer fraction from the dimerization step, (c) converting the branched, substantially unsaturated fatty acids from step (b) into the corresponding fatty acid methyl esters, (d) hydrogenating the branched, substantially unsaturated fatty acid methyl esters with the double bonds intact to form the corresponding branched, substantially unsaturated fatty alcohols and (e) sulfating and neutralizing the branched, substantially unsaturated fatty alcohols. The fatty alcohol sulfates thus produced exhibit improved performance properties and greater oxidative stability than standard unsaturated fatty alcohol sulfates.Type: GrantFiled: June 19, 2002Date of Patent: April 20, 2004Assignee: Cognis Deutschland GmbH & Co. KGInventors: Norbert Huebner, Hans-Christian Raths, Alfred Westfechtel
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Patent number: 6723868Abstract: The invention relates to a novel process for the preparation of an aminoalcohol of the formula racemically or optically active, starting from 2-azabicyclo[2.2.1]hept-5-en-3-one, its further conversion to give the corresponding acyl derivative and its further conversion to (1S,4R)- or (1R,4S)-4-(2-amino-6-chloro-9H-purine-9-yl)-2-cyclopentenyl-1-methanol of the formulae In the latter synthesis, the aminoalcohol is converted into the corresponding D- or L-tartrate, which is then reacted with N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide of the formula to give (1S,4R)- or (1R,4S)-4-[(2-amino-6-chloro-5-formamido-4-pyrimidinyl)amino]-2-cyclopentenyl-1-methanol of the formulae and then cyclized to give the end compounds.Type: GrantFiled: November 24, 1998Date of Patent: April 20, 2004Assignee: Lonza AGInventors: Walter Brieden, Josef Schröer, Christine Bernegger-Egli, Eva Maria Urban, Michael Petersen, Jean-Paul Roduit, Katja Berchtold, Holger Breitbach
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Patent number: 6723869Abstract: For the production of acrylonitrile by ammoxidation of propylene, there is provided a catalyst capable of giving a high yield for a long period of time. In producing acrylonitrile by ammoxidation of propylene, there is used a metal oxide as a catalyst, which metal oxide contains iron, antimony, molybdenum, bismuth, potassium, an F element, a G element, an H element and silica as essential components in a specific composition ratio, and in which metal oxide iron antimonate exists as a crystal phase, provided that the F element is at least one element selected from the group consisting of magnesium, calcium, strontium, barium, manganese, cobalt, nickel, copper, silver, zinc and cadmium, the G element is at least one element selected from the group consisting of chromium, aluminum, gallium and indium, and the H element is at least one element selected from the group consisting of yttrium, lanthanum, cerium, praseodymium, neodymium and samarium.Type: GrantFiled: April 9, 2002Date of Patent: April 20, 2004Assignee: Mitsubishi Rayon Co., Ltd.Inventors: Kunio Mori, Yutaka Sasaki, Kenichi Miyaki, Hirokazu Watanabe
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Patent number: 6723870Abstract: Disclosed is a method for producing anthracene of formula (II) below by mixing a reaction mixture with a primary alcohol, wherein the reaction mixture is a reaction mixture obtained by reacting a metal hydride with an anthraquinone of formula (I):Type: GrantFiled: September 24, 2002Date of Patent: April 20, 2004Assignee: Sumitomo Chemical Company, LimitedInventors: Takashi Kamikawa, Junji Morimoto
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Patent number: 6723871Abstract: A novel production process capable of obtaining an optically active alcohol in a high optical purity by subjecting a &bgr;-keto ester such as a 3-perfluoroalkyl-3-oxopropionate ester or a 3-trichloroalkyl-3-oxopropionate ester to asymmetric reduction in simple and convenient operations.Type: GrantFiled: May 13, 2002Date of Patent: April 20, 2004Assignee: Takasago International CorporationInventors: Kenichi Tada, Takashi Miura
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Patent number: 6723872Abstract: The present invention provides: a process in which, when a hydroxyalkyl ester is produced by carrying out a reaction between a carboxylic acid and an alkylene oxide in the presence of a catalyst, the contamination of the hydroxyalkyl ester with water can be inhibited to the maximum limit without washing the inside of a production apparatus together with the raw carboxylic acid or the hydroxyalkyl ester as an aimed product, or without carrying out azeotropic distillation with water and an azeotropic solvent. The process comprises a washing step and thereafter a drying step in the interval of from the stop of a production of the hydroxyalkyl ester till the restart of this production, wherein the washing step is a step of washing the inside of a production apparatus with water and/or an aqueous basic solution, and wherein the drying step is a step of drying under reduced pressure and/or hot-air-drying the inside of the production apparatus.Type: GrantFiled: January 30, 2002Date of Patent: April 20, 2004Assignee: Nippon Shokubai Co., Ltd.Inventors: Yasuhiro Shingai, Kouji Deguchi
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Patent number: 6723873Abstract: A process for forming reactants useful in the manufacture of polyethylene terephthalate includes the steps of: (a) contacting recyclable polyethylene terephthalate with ammonium hydroxide whereby a mixture of ammonium terephthalate and ethylene glycol is formed, (b) separating the ammonium terephthalate, and (c) heating said ammonium terephthalate at a temperature from about 225° C. to about 300° C. to produce terephthalic acid.Type: GrantFiled: August 30, 2000Date of Patent: April 20, 2004Assignee: Eastman Chemical CompanyInventor: William Speight Murdoch
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Patent number: 6723874Abstract: Acid fluorides, for example carboxylic acid fluorides and sulfuryl fluoride are produced by reacting the corresponding acid chlorides with hydrogen fluoride adducts of ammonium fluoride or amine hydrofluorides (which act as a catalyst or as a fluorination agent). Consumed HF adducts may be regenerated with HF.Type: GrantFiled: May 30, 2001Date of Patent: April 20, 2004Assignee: Solvay Fluor und Derivate GmbHInventors: Max Braun, Matthias Rieland, Francine Janssens, Kerstin Eichholz, Stefan Palsherm