Patents Issued in November 9, 2004
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Patent number: 6815504Abstract: An improved pressure sensitive adhesive includes a base polymer and a PIB modifier that is made up of a homopolymer of isobutylene wherein a predominant portion of the double bonds are in either an alpha position or a beta position. The modifier may function as a plasticizer, a tackifier extender or a combination plasticizer and tackifier extender for the pressure sensitive adhesive.Type: GrantFiled: February 4, 2003Date of Patent: November 9, 2004Assignee: Texas Petrochemicals, LPInventor: Betty L. Gipson
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Patent number: 6815505Abstract: An organic block polymer useful in an electroluminescent polymer device (or in a polymer field effect transistor) that includes an emissive polymer block that is consistently conjugated along the backbone of the emissive polymer block (e.g., a copolymer of 2,7-linked 9,9 dioctyl fluorene and 4,7-linked 2,1,3 benxothiadiazole); and a positive charge carrier polymer block that is consistently conjugated along the backbone of the positive charge carrier polymer block (e.g., a copolymer of 2,7-linked 9,9 dioctyl fluorene and 4N, 4N′-linked N,N′-di(3-carboxomethoxyphenyl)benzidine) for transporting positive charge carriers to the emissive polymer block so that the positive charge carriers can combine with negative charge carriers to generate light.Type: GrantFiled: July 10, 2002Date of Patent: November 9, 2004Assignee: Dow Global Technologies Inc.Inventors: Weishi Wu, Michael Inbasekaran, Mark T. Bernius, James J. O'Brien
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Patent number: 6815506Abstract: A thermoplastic elastomer composition having excellent heat aging characteristics, weather resistance, low-temperature physical properties, oil resistance and flexibility, and moldings using the same, such as hoses, are disclosed. The thermoplastic elastomer composition is obtained by dynamically heat treating a mixture containing (A) an olefin resin, (B) an unsaturated group-containing acrylic rubber, and (D) an inorganic filler in the presence of (E) a crosslinking agent, the component (B) comprising (B1) from 55 to 94.99% by weight of a structural unit derived from an acrylic acid alkyl ester monomer and/or an acrylic acid alkoxyalkyl ester monomer, (B2) from 0.Type: GrantFiled: October 11, 2002Date of Patent: November 9, 2004Assignee: JSR CorporationInventors: Masaaki Takashima, Katsutaka Yokoi, Minoru Tsuneyoshi
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Patent number: 6815507Abstract: A golf ball having an improved shot feel without deterioration in durability and flight performance is provided. The golf ball is constituted of at least two layers including a core and a cover. The core is formed of a rubber composition including 100 parts by weight of a rubber component, 0.01 to 0.5 parts by weight of sulfur and 0.05 to 5 parts by weight of an organic sulfur compound. An amount of deformation of the core under a load from an initial load of 98 N to a final load of 1274 N is 2.5 to 6.0 mm. A difference determined by subtracting a center hardness of the core from a surface hardness of the core is at least 25 in terms of JIS-C hardness.Type: GrantFiled: May 31, 2002Date of Patent: November 9, 2004Assignee: Sumitomo Rubber Industries, Ltd.Inventor: Keiji Ohama
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Patent number: 6815508Abstract: A polypropylene/ethylene block copolymer, which has a poly(ethylene-co-propylene) segment content of 5 to 100 wt. %, excluding 100 wt. %, and a total ethylene content of 2 to 95 wt. %. (a) The block polymer comprises polypropylene segments and poly(ethylene-co-propylene) segments chemically bonded thereto, and (b) the polypropylene segments and the poly(ethylene-co-propylene) segments have been synthesized in the presence of an olefin polymerization catalyst comprising an organometallic compound and a solid catalyst component comprising either titanium and a halogen, or titanium, magnesium, and a halogen. The block copolymer has a weight-average molecular weight of 100,000 or higher, is suitable for producing general-purpose molded articles, and has an excellent balance among mechanical properties, impact resistance, thermal properties, transparency, moldability, and other properties.Type: GrantFiled: July 9, 2001Date of Patent: November 9, 2004Assignees: Chisso Petrochemical Corporation, Japan Science and Technology CorporationInventors: Minoru Terano, Tetsuya Matsukawa, Hideshi Satake, Masato Takahashi
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Patent number: 6815509Abstract: A process for hydrogenating a polymer, which process comprises contacting a polymer containing an olefinic unsaturated group with hydrogen in the presence of a hydrogenation catalyst to hydrogenate the olefinic unsaturated group of the polymer, and recycling at least one part of the hydrogenated polymer for hydrogenation. According to the process of the present invention, there can be provided a polymer having a desirable degree of hydrogenation steadily for a long period.Type: GrantFiled: February 19, 2002Date of Patent: November 9, 2004Assignee: Asahi Kasei Kabushiki KaishaInventors: Koichi Miyamoto, Yasumasa Yamakoshi, Toshinori Shiraki
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Patent number: 6815510Abstract: The present invention relates to elastomeric compositions and methods including compositions and methods involving the use of aromatic alcohols. The present invention further relates to elastomeric compositions that can include ground reclaimed elastomeric particles. Compositions of the present invention are usable in numerous elastomeric applications including interior and exterior vehicle parts, roofing, asphalt, and any other applications that employ an elastomer as an ingredient thereof, particularly those utilizing rubber or a similar elastomer. The present invention further is directed to asphalt compositions and their methods of manufacture and use.Type: GrantFiled: November 15, 2002Date of Patent: November 9, 2004Inventors: Michael W. Rouse, Victor M. Deeb, Morgan L. White, Magdy Abdelrahman
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Patent number: 6815511Abstract: An improved polymerization process includes withdrawing a portion of a fluid slurry through a plurality of active continuous take off mechanisms, monitoring the pressure of feed material fed to the reactor, and adjusting the continuous take off mechanisms in response to the monitored feed line pressure.Type: GrantFiled: September 23, 2003Date of Patent: November 9, 2004Assignee: Chevron Phillips Chemical Company, LPInventors: Donald W. Verser, David H. Burns, James E. Hein, George K. Rajaendran, John D. Hottovy
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Patent number: 6815512Abstract: The partially condensed fluid recycle stream of a fluidized bed polyolefin reactor operating in the condensing mode is split into two portions by a stream splitter. In a preferred mode, the smaller stream from the splitter contains a higher ratio of liquid to gas than the larger stream. One portion of the split stream is injected below the fluidized bed and the other, preferably with enhanced liquid content, is injected into the fluidized bed at a level above the product withdrawal level. Regulation of liquid injection above the product withdrawal level, as a function of liquid in the product discharge tanks, reduces the liquid in the product discharge system, resulting in improved discharge cycle times and more efficient conservation of monomer and other materials which might otherwise be lost in the discharge process.Type: GrantFiled: February 5, 2001Date of Patent: November 9, 2004Assignee: Union Carbide Chemicals & Plastics Technology CorporationInventors: Robert Darrell Olson, Timothy Joseph Howley
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Patent number: 6815513Abstract: A continuous process for making a comb-branched copolymer of an acrylic monomer and a polyether macromonomer is disclosed. The process is performed by continuously feeding a reaction zone with a monomer stream that contains an acrylic acid and a polyether macromonomer, and an initiator stream. The comb-branched copolymer made thereby performs better as water reducing agent in cement compared to that made by a batch process.Type: GrantFiled: January 16, 2001Date of Patent: November 9, 2004Assignee: Arco Chemical Technology, L.P.Inventors: Bi Le-Khac, Wei Wang, Edward T. Shawl
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Patent number: 6815514Abstract: The invention describes ligands of formula (I), wherein LIG represents an &eegr;5-ligand substituted by a group R1 and a group (R″)m; X represents a 1 to 3 atom bridge; Y represents a nitrogen or phosphorus atom; Z represents a carbon, nitrogen or phosphorus atom.Type: GrantFiled: May 28, 2003Date of Patent: November 9, 2004Assignee: Borealis Technology OyInventors: Ove Andell, Janne Maaranen, Jouni Hoikka, Tiina Vanne, Soile Rautio
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Patent number: 6815515Abstract: A low color or colorless polymaleate as determined by a Gardner color number of 8 or less, said polymaleate is prepared by aqueous solution polymerization of 70 to 99.9 weight percent of maleic acid, 0.1 to 30 weight percent of an allylic sulfonate monomer, and 0.5 to 50 &mgr;m, based on the moles of monomer, of a polyvalent transition metal ion selected from group consisting of Group IVA, VA, VIA, VIIA, VIIIA, IB, IIB, and combinations thereof, wherein the weight percents are based on the total weight of monomer, provided that 10 to 60 mole percent of the carboxylic acid groups on the maleic acid are neutralized prior to polymerization. The low color or colorless polymaleates provide permanent press properties to textiles treated therewith and increases the resistance of such textiles to laundering abrasion. The polymaleates also may be used in cleaning compositions to disperse and suspend soils.Type: GrantFiled: February 25, 2002Date of Patent: November 9, 2004Assignee: National Starch and Chemical Investment Holding CorporationInventors: Anne-Marie Austin, Allen M Carrier, Klein A Rodrigues
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Patent number: 6815516Abstract: A ring-opened metathesis copolymer formed by the ring-opening metathesis copolymerization of a cycloolefin monomer having a carboxylic anhydride group selected from bicycloheptene derivatives, tetracyclododecene derivatives and hexacycloheptadecene derivatives with a cycloolefin monomer selected from bicycloheptene derivatives, tetracycloheptene derivatives and hexacycloheptene derivatives; and a hydrogenation product of the copolymer. This copolymer is produced by using a polymerization catalyst comprises an organoruthenium compound having a heterocyclic carbene compound as a ligand. The ring-opened metathesis copolymer and the hydrogenation product thereof have a low dielectric constant, a low water absorption, a high adhesion to metals and a high heat resistance.Type: GrantFiled: June 7, 2002Date of Patent: November 9, 2004Assignee: Zeon CorporationInventors: Masato Sakamoto, Yasuo Tsunogae
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Patent number: 6815517Abstract: An at least two-component mortar composition is described, which can be cured by thermal initiation and contains at least one polymerizable monomer and/or at least one curable resin, at least one polymerization initiator for the polymerizable monomer and/or the curable resin and optionally at least one filler, wherein, as polymerization initiator, at least one organically substituted ammonium salt is contained as constituent of a mortar component and at least one inorganic persulfate is contained as constituent of a further mortar component, and which, after the mortar components are mixed in situ, results in an organically substituted ammonium persulfate, the nature and amount of organically substituted ammonium salt and inorganic persulfate as well as of polymerizable monomer or curable resin being selected so that a mortar composition results, which can be polymerized by free radical polymerization due to the action of heat, as well as a method for fastening tie rods, reinforcing steel for concrete or theType: GrantFiled: July 1, 2002Date of Patent: November 9, 2004Assignee: Hilti AktiengesellschaftInventors: Thomas Bürgel, Marianne Böck
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Patent number: 6815518Abstract: The invention concerns a method for preparing functionalised silicone oils with controlled viscosity by hydrosilylation of polyorganohydrogenosiloxanes with synthons, identical or different, containing at least a hydrocarbon cycle wherein is included an oxygen atom, said reaction being carried out in the presence of a catalytic metal complex.Type: GrantFiled: July 23, 2003Date of Patent: November 9, 2004Assignee: Rhodia ChimieInventor: Sébastien Sterin
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Patent number: 6815519Abstract: The present invention discloses an acidic fluorine-containing hybrid having a uniform distribution of an organic and an inorganic components prepared by a sol-gel process. The organic component is a fluorine-containing poly(siloxane amideimide) having a good processing ability, gas permeability, mechanical properties, and chemical stability. The inorganic component is silica having good heat resistance and moisture resistance. The hybrid has excellent properties, such as a good film formation property, a high gas selectivity, a low dielectric constant, a good resistance to scraping, and a good transparency, etc., and can be used in making industrial products, such as gas detection films, sensors, encapsulation material, photoelectrical communication material, and biomedical material, etc.Type: GrantFiled: March 22, 2002Date of Patent: November 9, 2004Assignee: Chung-Shan Institute of Science & TechnologyInventors: Yie-Shun Chiu, Hsing-Tsai Huang, Te-Chuan Chang, Gaw-Pying Wang, Yaw-Shun Hong
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Patent number: 6815520Abstract: An addition curing type silicone resin composition is provided including (A) 100 parts by weight of a specific organopolysiloxane with a phenyl group and at least two alkenyl groups within each molecule, (B) 1 to 100 parts by weight of a specific organohydrogenpolysiloxane with a phenyl group and at least two SiH groups within each molecule, and (C) an effective quantity of a hydrosilylation reaction catalyst. A cured product obtained by curing this composition is transparent, displays good strength and particularly good flexural strength, and moreover also displays a high degree of hardness. The composition is applicable to a variety of fields including electrical and electronic equipment, OA equipment and precision instruments.Type: GrantFiled: March 6, 2002Date of Patent: November 9, 2004Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Yoshinori Yoneda, Masaaki Yamaya, Akinari Itagaki
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Patent number: 6815521Abstract: A multi-piece golf ball with a two-part curing type polyurethane cover is provided, which is satisfactory in moldability and ball characteristics such as a abrasion resistance and a carry. The multi-piece golf ball according to this invention has a core having an increased diameter and provided with a hardness difference between its surface portion and its central portion. This feature imparts the multi-piece golf ball with such characteristics as a high repulsion property, high shot angle and low spin count, thereby making the golf ball ensure an increased carry. The polyurethane cover of the multi-piece golf ball, which is formed from a two-part curing type polyurethane including a specific isocyanate group-terminated urethane prepolymer and an aromatic polyamine compound, is excellent in durability and abrasion resistance.Type: GrantFiled: October 3, 2002Date of Patent: November 9, 2004Assignee: Sumitomo Rubber Industries LimitedInventor: Satoshi Iwami
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Patent number: 6815522Abstract: This thermoplastic elastomer is present in a substantially solid state suitable for use as a binder for a propellant, explosive, and/or gas generant of a supplemental restraint system. The thermoplastic elastomer is formed from a composition including A blocks which are crystalline at temperatures below about 75° C. and B blocks which are amorphous at temperatures above about −20° C. The A blocks are derived from oxetane derivatives and/or tetrahydrofuran derivatives. The B blocks are derived from oxetanes, tetrahydrofuran, oxiranes, and derivatives thereof. The A and B blocks are end-capped with at least one diisocyanate and linked with at least one difunctional oligomer having two functional groups which are reactive with free and unreacted isocyanate moieties of the diisocyanate.Type: GrantFiled: November 9, 1999Date of Patent: November 9, 2004Assignee: Alliant Techsystems Inc.Inventors: Andrew J. Sanderson, Wayne Edwards
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Patent number: 6815523Abstract: The object of the present invention is to provide an organic polymer excellent in heat resistance and chemical resistance and having a low dielectric constant. This object can be achieved by a polyether resin having a repeating unit of following formula (1): wherein R1 to R3 independently represent hydrogen atom, a halogen atom, or a substituent, or two of R1 to R3 may be mutually bonded to form a ring; R4 denotes hydrogen atom, an alkyl group with 1 to 10 carbons which may be substituted, a cycloalkyl group with 6 to 10 carbons which may be substituted, an aromatic ring with 6 to 14 carbons which may be substituted, a trialkylsilyl group which may be substituted, or a hydroxyalkyl; and Ar represents a divalent aromatic ring.Type: GrantFiled: March 13, 2003Date of Patent: November 9, 2004Assignee: Sumitomo Chemical Company, LimitedInventor: Akira Yokota
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Patent number: 6815524Abstract: Polycarbonate substrates having low concentration of defects are disclosed. The substrates are suitable for producing molded articles characterized by low cloudiness.Type: GrantFiled: August 5, 2002Date of Patent: November 9, 2004Assignees: Bayer Aktiengesellschaft, Bayer Antwerpen N.V.Inventors: Michael Bödiger, Steffen Kühling, Franky Bruynseels, Dirk van Meirvenne, Renë de Cleyn
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Patent number: 6815525Abstract: A process for introducing a component into a reaction fluid and/or process fluid comprising the steps of: (a) providing a recirculation loop having an influent and an effluent wherein the influent is in fluid communication with a reaction fluid; (b) recirculating at least a portion of the reaction fluid of step (a) through the recirculation loop wherein the reaction fluid flowing through the recirculation loop is a recirculation fluid; (c) decreasing the pressure of the recirculation fluid of step (b) with at least one pressure decreasing device at at least one point in the recirculation loop; and (d) feeding a component into the recirculation loop adjacent to or at the pressure decreasing device of step (c), to thereby introduce a component into the reaction fluid.Type: GrantFiled: December 7, 2001Date of Patent: November 9, 2004Assignee: Eastamn Chemical CompanyInventor: Bruce Roger DeBruin
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Patent number: 6815526Abstract: There is provided a wholly aromatic polyester which has excellent heat resistance and can be produced by an ordinary polymerizer and melt-molded with ease. That is, a wholly aromatic polyester which contains, as essential constituents, the constitutional unit represented by the following general formula (I) in an amount of 40 to 75 mol %, the constitutional unit represented by the following general formula (II) in an amount of 8.5 to 30 mol %, the constitutional unit represented by the following general formula (III) in an amount of 8.5 to 30 mol % and the constitutional unit represented by the following general formula (IV) in an amount of 0.1 to 8 mol % based on the total of all constitutional units and which exhibits optical anisotropy in a molten state.Type: GrantFiled: February 13, 2003Date of Patent: November 9, 2004Assignee: Polyplastics Co., Ltd.Inventors: Toshiaki Yokota, Kazunari Takada
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Patent number: 6815527Abstract: The continuous process for preparing a polyamide by reacting at least one aminonitrile with water comprises: (1) reacting at least one aminonitrile with water in the presence of an organic liquid diluent at from 90 to 400° C. and from 0.1 to 35×106 Pa in a flow tube containing a Brönsted acid catalyst selected from a beta-zeolite catalyst, a sheet-silicate catalyst or a titanium dioxide catalyst comprising from 70 to 100% by weight of anatase and from 0 to 30% by weight of rutile and in which up to 40% by weight of the titanium dioxide may be replaced by tungsten oxide, to obtain a reaction mixture, (2) further reacting the reaction mixture at from 150 to 400° C.Type: GrantFiled: January 10, 2003Date of Patent: November 9, 2004Assignee: BASF AktiengesellschaftInventors: Peter Bassler, Helmut Winterling, Rolf-Hartmuth Fischer, Wolfgang Loth
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Patent number: 6815528Abstract: The invention provides generally a new type of organic electrochromic Near Infrared (NIR)-active materials capable of absorbing and attenuating the light in the NIR region around 1550 nm and forming thin films on electrodes for variable optical attenuator (VOA) applications. They have utility in planar VOA devices. The materials are ruthenium complexes. Unsymmetrical complexes having two different substituents are disclosed, where one substituent is more electron-donating than the other. Complexes which are dimers or trimers (symmetrical or unsymmetrical) are disclosed, as are polymeric complexes. Crosslinked polymeric complex films are also disclosed.Type: GrantFiled: May 22, 2002Date of Patent: November 9, 2004Assignee: TWLinks Inc.Inventor: Zhi Yuan Wang
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Patent number: 6815529Abstract: This invention relates to a catalyst for producing aliphatic polycarbonate, which is composed of a rare-earth coordination compound; an alkyl metal compound; a polyol; and a carbonate. The catalytic efficiency of the catalyst of the present invention is more than 8×104 g polymer/mol RE(RE is rare earth metal). The number average molecular weight of the polymer is higher than 30,000. The degree of carbon dioxide fixation is more than 42 wt % and the content of alternative sequence structure exceeds 97%.Type: GrantFiled: August 29, 2001Date of Patent: November 9, 2004Assignee: Changchun Institute of Applied Chemistry Chinese Academy of SciencesInventors: Xiaojiang Zhao, Xianhong Wang, Fosong Wang
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Patent number: 6815530Abstract: Methods of synthesizing a substantially monodispersed mixture of polymers comprising polyethylene glycol moieties include: reacting a substantially monodispersed mixture of compounds having the structure of Formula I: R1(OC2H4)n—O−X+ (I) wherein R1 is H or a lipophilic moiety; n is from 1 to 25; and X+ is a positive ion, with a substantially monodispersed mixture of compounds having the structure of Formula II: R2(OC2H4)m—OMS (II) wherein R2 is H or a lipophilic moiety; and m is from 1 to 25, under conditions sufficient to provide a substantially monodispersed mixture of polymers comprising polyethylene glycol moieties and having the structure of Formula III: R2(OC2H4)m+n—OR1 (III). Substantially monodispersed mixtures of polymers comprising polyethylene glycol moieties are also disclosed.Type: GrantFiled: February 14, 2003Date of Patent: November 9, 2004Assignee: Nobex CorporationInventors: Nnochiri N. Ekwuribe, Christopher H. Price, Aslam M. Ansari, Amy L. Odenbaugh
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Patent number: 6815531Abstract: DNA encoding a protein having the amino acid sequence shown in SEQ ID NO: 2 or a variant protein thereof in which one or more amino acid residues are substituted, deleted or added, said protein or variant protein thereof being capable of yielding, through its intracellular decomposition, peptide fragment(s) which can bind to major histocompatibility complex (MHC) class I antigen and which can be recognized by T cells in such binding state, medicines comprising said DNA as an active ingredient, expression plasmids comprising said DNA, transformants transformed with said expression plasmids, as well as tumor antigen proteins and tumor antigen peptides produced by expression of said DNA.Type: GrantFiled: December 7, 1998Date of Patent: November 9, 2004Inventors: Kyogo Itoh, Shigeki Shichijo, Yasuhisa Imai
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Patent number: 6815532Abstract: Polynucleotides encoding novel Atr-2 cell cycle checkpoint polypeptides are disclosed, along with expression constructs comprising the polynucleotides, host cells transformed with the expression constructs, methods to make the Atr-2 polypeptides using the host cells, Atr-2 polypeptides, and binding partners of the Atr-2 polypeptides.Type: GrantFiled: September 21, 2001Date of Patent: November 9, 2004Assignee: ICOS CorporationInventors: Kate Loughney, Kathleen S. Keegan
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Patent number: 6815533Abstract: The present invention is directed at a method of processing an aqueous solution of protein C into a state suitable for storage, handling, and recovery. The present invention provides aqueous activated protein C solutions and an improved method of processing such solutions into cryogranules.Type: GrantFiled: January 22, 2001Date of Patent: November 9, 2004Assignee: Eli Lilly and CompanyInventors: Jeffrey Clayton Baker, Nancy Delores Jones
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Patent number: 6815534Abstract: The present invention relates to a novel t-PALP protein which is a member of the serine protease family. In particular, isolated nucleic acid molecules are provided encoding the human t-PALP protein. t-PALP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of t-PALP activity. Also provided are diagnostic methods for detecting circulatory system-related disorders and therapeutic methods for treating circulatory system-related disorders.Type: GrantFiled: January 29, 2002Date of Patent: November 9, 2004Assignee: Human Genome Sciences, Inc.Inventors: Paul A. Moore, Steven M. Ruben, Reinhard Ebner
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Patent number: 6815535Abstract: Method of obtaining a fibrinogen enriched preparation by (i) adding an effective amount of a sulphated polysaccharide (SPS) to a fibrinogen containing solution to form a fibrinogen containing precipitate and (ii) extracting fibrinogen from the fibrinogen containing precipitate from step (i) with a solution containing at least 0.1M salt to obtain a fibrinogen enriched preparation.Type: GrantFiled: August 1, 2000Date of Patent: November 9, 2004Assignee: CSL LimitedInventors: Jerry Kanellos, Teresa Martinelli, Grace Demaria, Neil Goss
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Patent number: 6815536Abstract: A monoazo reactive red dyestuff of the formula (I), wherein the R1, R2, R3, X, D, Z and n are as defined in the description. These kinds of dyestuffs are suitable for dyeing and printing of materials containing either cellulose fibers, such as cotton, artificial cotton, linen, and artificial linen, or synthetic polyamide, such as wool, silk, and nylon etc., as well as on mixed or cross-linked cellulose fibers and other fibers. Dyed materials with excellent properties can be obtained, showing especially outstanding performance in of wash-off, level-dyeing, light fastness and perspiration-light fastness.Type: GrantFiled: October 17, 2002Date of Patent: November 9, 2004Assignee: Everlight USA, Inc.Inventors: Huei-Chin Huang, Chia-Huei Yu
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Patent number: 6815537Abstract: The present invention relates to cloned DNA containing origin of DNA replication and to cloned DNA encoding repliation protein, RepT.Type: GrantFiled: September 18, 2000Date of Patent: November 9, 2004Assignee: New England Biolabs, Inc.Inventors: Jay Wayne, Shuang-yong Xu
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Patent number: 6815538Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.Type: GrantFiled: March 20, 2001Date of Patent: November 9, 2004Assignee: Lexicon Genetics IncorporatedInventors: D. Wade Walke, Nathaniel L. Wilganowski, C. Alexander Turner, Jr., Erin Hilbun, Xiaoming Wang, Gregory Donoho, John Scoville
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Patent number: 6815539Abstract: The invention provides isolated nucleic acid and amino acid sequences of Slo3, a pH sensitive potassium channel expressed in sperm; antibodies to Slo3; methods of screening for Slo3 inhibitors; and methods of screening for Slo3 homologs.Type: GrantFiled: October 21, 1998Date of Patent: November 9, 2004Assignees: Icagen, Incorporated, The Washington UniversityInventors: Lawrence Salkoff, Matthew Schreiber, Chris Silvia
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Patent number: 6815540Abstract: The present invention relates to the modification of immunoglobulin superfamily (IgSF) domains, IgSF fragments and fusion proteins thereof, especially to the modification of antibody derivatives, so as to improve their solubility, and hence the yield, and ease of handling. The inventors have found that this can be achieved by making the region which comprised the interface with domains adjoined to said IgSF domain in a larger fragment or a full IgSF protein, and which becomes exposed in the IgSF domain, more hydrophilic by modification. The present invention describes DNA sequences encoding modified IgSF domains or fragments and fusion proteins thereof, vectors and hosts containing these DNA sequences, IgSF domains or fragments or fusion proteins obtainable by expressing said DNA sequences in suitable expression systems, and a method for modifying IgSF domains, so as to improve their solubility, expressibility and ease of handling.Type: GrantFiled: January 15, 1999Date of Patent: November 9, 2004Assignee: University of ZurichInventors: Andreas Plückthun, Lars Nieba, Annemarie Honegger
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Patent number: 6815541Abstract: A coprecipitant and a nucleic-acid extraction method using the coprecipitant are provided. The coprecipitant has affinity to the nucleic acids, no competitive inhibition to the reverse transcription and no inhibition to the PCR reaction in case of extracting a very small amount of nucleic acids by alcoholic precipitation using isopropyl alcohol or ethanol. Further, the coprecipitant can precipitate with the nucleic acids as a visible white or blue precipitate, thereby to suppress technical errors and enhance the extraction efficiency. A coprecipitant which acts in a process of extracting the nucleic acids by centrifugal separation from biological materials and/or test samples in the same manner as nucleic acids and has ability for precipitating as a visible white or blue precipitate when being separating and concentrating it by alcohol.Type: GrantFiled: April 18, 1997Date of Patent: November 9, 2004Assignee: Palma Bee'z Research Institute Co., Ltd.Inventors: Mitsugu Usui, Mari Yamaguchi, Motohito Kaneshima, Akiji Aoki
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Patent number: 6815542Abstract: Nucleosides, novel nucleoside analog compounds and their novel prodrug forms are disclosed. The novel compounds, prodrugs, or pharmaceutically acceptable esters or salts thereof may be used in pharmaceutical compositions, and such compositions may be used to treat an infection, an infestation, a neoplasm, or an autoimmune disease. The novel compounds may also be used to modulate aspects of the immune system, including modulation of Type 1 and Type 2 activity.Type: GrantFiled: December 13, 2002Date of Patent: November 9, 2004Assignee: Ribapharm, Inc.Inventors: Zhi Hong, Jean-Luc Girardet, Kanda Ramasamy, Johnson Lau
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Patent number: 6815543Abstract: Oxidation of organic compounds is catalyzed by addition of a catalytic amount of a metalloporphyrin in a non-reactive aprotic solvent.Type: GrantFiled: February 8, 2002Date of Patent: November 9, 2004Assignee: Warner-Lambert CompanyInventor: Patrick Bernardelli
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Patent number: 6815544Abstract: An efficient process is described for the synthesis of 5, a key intermediate for the synthesis of the potent antitumor agents ecteinascidin 743 (1) and phthalascidin (2) from the readily available building blocks 3b and 4.Type: GrantFiled: August 7, 2002Date of Patent: November 9, 2004Assignee: President and Fellows of Harvard CollegeInventor: Elias J. Corey
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Patent number: 6815545Abstract: A process for the production of melamine by pyrolysis of urea in a high-pressure reactor having a vertical central pipe is provided. The melamine flows upwards into the reactor from below, mixes in the lower part of the reactor with a urea melt, and optionally NH3, introduced into the reactor from below, and emerges from the central pipe in the upper part of the central pipe. Part of the melamine formed flows downward in the annular space between the central pipe and reactor wall, and the remainder is expelled for further work-up. The off-gases are removed at the top of the reactor. A reactor for carrying out the process is also provided.Type: GrantFiled: October 7, 2003Date of Patent: November 9, 2004Assignee: Agrolinz Melamin GmbHInventors: Hartmut Bucka, Gerhard Coufal, Ferdinand Koglgruber
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Patent number: 6815546Abstract: A compound of the formula wherein the substituents are defined as in the specification which compounds are useful in the treatment of cancer.Type: GrantFiled: February 6, 2002Date of Patent: November 9, 2004Assignee: Societe de Recherches et d'Applications Scientifiques (S.C.R.A.S.)Inventors: Dennis Bigg, Olivier Lavergne, Francesc Pla Rodas, Jacques Pommier, Gérard Ulibarri, Jerry Harnett, Alain Rolland, Anne-Marie Liberatore, Christophe Lanco, Jean-Bernard Cazaux, Christine Le Breton, Eric Manginot
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Patent number: 6815547Abstract: Quinolylpropylpiperidine derivatives of general formula (I) are described, and are useful as antimicrobial agents. Their preparation is also described.Type: GrantFiled: March 14, 2003Date of Patent: November 9, 2004Assignee: Aventis Pharma S.A.Inventors: Eric Bacque, Serge Mignani, Jean-Luc Malleron, Michel Tabart, Michel Evers, Fabrice Viviani, Youssef El Ahmad, Stéphane Mutti, Christophe Daubié
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Patent number: 6815548Abstract: A piperidine derivative, which can be used as an intermediate for pharmaceuticals such as paroxetine useful as antidepressants, represented by the general formula (I): wherein R1 is hydrogen atom, benzyloxycarbonyl group or tert-butoxycarbonyl group; R2 is hydroxymethyl group, an alkylsulfonyloxymethyl group having an alkyl moiety of 1 to 2 carbon atoms, phenylsulfonyloxymethyl group which may have methyl group at the 4-position, (3,4-methylenedioxyphenyl)oxymethyl group, carboxyl group or —CO2R7 group in which R7 is an alkyl group having 1 to 5 carbon atoms, and Z is methylene group or carbonyl group, with proviso that, (A) when R1 is benzyloxycarbonyl group or tert-butoxycarbonyl group, then R2 is hydroxymethyl group, an alkylsulfonyloxymethyl group having an alkyl moiety of 1 to 2 carbon atoms, phenylsulfonyloxymethyl group which may have methyl group at the 4-position or (3,4-methylenedioxyphenyl)oxymethyl group, and Z is methylene group; or (B) when R1 is hydrogen atom and Z is caType: GrantFiled: January 6, 2003Date of Patent: November 9, 2004Assignee: Sumika Fine Chemicals Co., Ltd.Inventors: Kiyoshi Sugi, Nobushige Itaya, Tadashi Katsura, Masami Igi, Shigeya Yamazaki, Taro Ishibashi, Teiji Yamaoka, Yoshihiro Kawada, Yayoi Tagami
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Patent number: 6815549Abstract: A process for the preparation of 4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-butyl]-&agr;,&agr;-dimethylbenzeneacetic acid (Fexofenadine) of formulaType: GrantFiled: May 16, 2002Date of Patent: November 9, 2004Assignee: Dinamite Dipharma S.p.A.Inventors: Graziano Castaldi, Giuseppe Barreca, Domenico Magrone
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Patent number: 6815550Abstract: Provided is a process for preparing 2H-benzotriazole UV absorbers containing a perfluoroalkyl moiety at the 5-position of the benzoic ring, for example a trifluoromethyl group, which involves digitizing the perfluoroalkyl substituted o-nitroaniline using concentrated sulfuric acid plus sodium nitrite or nitrosylsulfuric acid to form the corresponding monoazobenzene intermediate via the diazonium salt intermediate which is reduced to the corresponding 5-perfluoroalkyl substituted 2H-benzotriazole UV absorber compound by conventional reduction means. Also provided is a novel one-pot, multiphase reaction for the preparation of 2(2-nitrophenylazo) substituted phenols, which are precursors for 2H-benzotriazole UV absorbers.Type: GrantFiled: December 10, 2002Date of Patent: November 9, 2004Assignee: Ciba Specialty Chemicals CorporationInventors: Mervin G. Wood, Deborah DeHessa, Joseph Suhadolnik, Andrew B. Naughton, Jerome Sanders, Jacqueline Lau, Rong Xiong, Joseph Babiarz
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Patent number: 6815551Abstract: A process for concentrating sterols and/or tocopherols from mixtures of fats and fatty derivatives and from residues left after they have been worked up is described. After splitting of the glycerides by hydrolysis and subsequent removal of the free fatty acids by distillation, the tocopherol/sterol esters still present are largely split into free tocopherols/sterols by an additional hydrolysis step.Type: GrantFiled: February 4, 2003Date of Patent: November 9, 2004Assignee: Cognis Deutschland GmbH & Co. KGInventors: Wolfgang Albiez, William G. Kozak, Thorsten Louwen
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Patent number: 6815552Abstract: Process for manufacturing an oxirane by reaction between an olefin and hydrogen peroxide in the presence of a catalyst and an organic diluent, according to which the hydrogen peroxide is an aqueous hydrogen peroxide solution obtained by extraction, with substantially pure water, of the mixture derived from the oxidation of at least one alkylanthrahydroquinone, without subsequent washing and/or purification treatment.Type: GrantFiled: December 19, 2002Date of Patent: November 9, 2004Assignee: Solvay (Societe Anonyme)Inventors: Michel Strebelle, Jean-Pierre Catinat
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Patent number: 6815553Abstract: The invention provides methods for separating outer birch bark from inner birch bark. The invention also provides methods for isolating betulin; lupeol; betulinic acid; 9,10-epoxy-18-hydroxyoctadecanoic acid; 9,10,18-trihydroxyoctadecanoic acid; polyphenolic polymers and fatty acids from birch bark.Type: GrantFiled: February 6, 2002Date of Patent: November 9, 2004Assignee: Regents of the University of MinnesotaInventors: Pavel A. Krasutsky, Robert M. Carlson, Vitaliy V. Nesterenko, Igor V. Kolomitsyn, Chris F. Edwardson