Abstract: A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site specific ligand activated with a biotin activating agent; (b) an avidin activating agent; and (c) lipid encapsulated particles activated with a biotin activating agent, whereby the ligand is conjugated to the particles through an avidin-biotin interaction and the resulting conjugate is bound to the molecular epitopes on such surface. The conjugate is effective for imaging by x-ray, ultrasound, magnetic resonance or positron emission tomography. Compositions for use in ultrasonic imaging of natural or synthetic surfaces and for enhancing the acoustic reflectivity thereof are also disclosed.

Abstract: Compounds of general formula (I): in which: R1 is hydrogen, C1–C20 alkyl, C3–C10 cycloalkyl, C4–C20 cycloalkylalkyl, aryl, arylalkyl, or two R1, taken together, form a straight or cyclic C2–C10 alkylene group or an ortho disubstituted arylene; R2 is hydrogen, C1–C20 alkyl, C3–C10 cycloalkyl, C4–C20 cycloalkylalkyl, aryl or aryl alkyl optionally substituted with functional groups which allow conjugation with a suitable molecule able to interact with physiological systems; R3, R4 and R5 are hydrogen, C1–C20 alkyl, C3–C10 cycloalkyl, C4–C20 cycloalkylalkyl, aryl, arylalkyl; and their chelates with bi-trivalent ions of the metal elements having atomic number ranging between 20 and 31, 39, 42, 43, 44, 49, and between 57 and 83, and radioisotopes chosen among 203Pb 67Ga 68Ga 72As 111In 113In 90Y 97Ru 62Cu 64Cu 52Fe 52mMn 140La 175Yb 153Sm 166Ho 149Pm 177Lu 142Pr 159Gd 212Bi 47Sc 149Pm 67Cu, 111Ag, 199Au, 161Tb and 51Cr as well as the salts thereof with physiologically compatible bases or acids

Abstract: The aim of the invention is to improve the moisture resistance of dry powder formulations for inhalation which contain a pharmaceutically ineffective carrier of not-inhalable particle size and a finely divided pharmaceutically active compound of inhalable particle size and to also improve the storage stability of said formulations. To this end, magnesium stearate is used in said formulations. One of the features of the inventive dry powder is that a high fine particle dosage or fine particle fraction can be maintained also under relatively extreme temperature and humidity conditions.

Abstract: The invention comprises a medicinal aerosol composition comprising a propellant, an excipient comprising an acid or amine end-group and at least one and no more than two amide and/or ester functional groups, and a drug. The invention also comprises particulate medicinal compositions comprising particles with a mean mass aerodynamic diameter of less than about 10 microns that incorporate an excipient containing an acid or amine end-group and at least one and no more than two amide and/or ester functional groups.

Abstract: The invention concerns a fatty ester mixture for cosmetic product, comprising at least two fatty esters selected among a branched C4–C8 mono carboxylic acid and a branched C8–C12 alcohol, the esters of a C8–C12 dicarboxylic acid the esters of a linear C8–C12 dicarboxylic acid and a branched C3–C6 alcohol and the esters of a hydroxycarboxylic acid and a linear C10–C18 alcohol. The invention is useful in cosmetics and more particularly for solar protection products.

Abstract: There is provided a photostable and synergistically enhanced topical sunscreen composition. There is further provided a method of enhancing the photostability of a sunscreen active in a topical sunscreen composition. There is further still provided a method of synergistically enhancing the UV absorbance of a sunscreen active in a topical sunscreen composition. The preferred compositions and methods of the present invention use a dibenzoylmethane sunscreen active, a Kaempferia galanga extract, and a cosmetically acceptable vehicle.

Abstract: The invention relates to deodorants and antiperspirants comprising at least one copolymer. The copolymer is obtained by free-radical copolymerization of A) acryloyldimethyltaurine and/or acryloyldimethyltaurates, and B) optionally, one or more further olefinically unsaturated, noncationic comonomers, C) optionally, one or more olefinically unsaturated, cationic comonomers, D) optionally, one or more silicon-containing component(s), E) optionally, one or more fluorine-containing component(s), F) optionally, one or more macromonomers, G) optionally, the copolymerization taking place in the presence of at least one polymeric additive, H) with the proviso that component A) is copolymerized with at least one component selected from one of the groups D) to G).

Abstract: Cosmetic compositions comprising, in a cosmetically acceptable medium, at least one aqueous emulsion of at least one silicone copolymer with a dynamic viscosity ranging from 1×106 to 100×106 cP and at least one associative thickener. This combination can give cosmetic properties, such as at least one of smoothness, lightness, and softness, without the phenomenon of regreasing keratin fibers. These compositions can be used for washing and/or conditioning a keratin material, such as the hair or the skin.

Abstract: Compositions and methods for treating peripheral artery disease in a patient are provided. Compositions comprise recombinant fibroblast growth factor-2. Fibroblast growth factor, such as FGF-2, is administered in therapeutically effective amounts to treat or prevent peripheral artery disease including claudication and critical limb ischemia. Pharmaceutical compositions comprising a therapeutically effective amount of FGF-2 and a pharmaceutically acceptable carrier are also provided. The methods of the invention to treat peripheral artery disease and claudication comprise administering at least a single dose of a pharmaceutical composition comprising the FGF, such as FGF-2, via intra-arterial, intravenous, or intramuscular infusion to the patient. It is recognized that increased benefits may result from multiple dosing, including intermittent dosing.

Abstract: The present invention relates to the identification and characterisation of a viral homologue (vCD30) of mammalian CD30. The vCD30 polypeptide is shown to have immunomodulatory activity and has various therapeutic applications.

Abstract: The present invention is based upon a surprising finding that stem cells, more particularly neural stem cells, can migrate throughout a brain tumor and track metastatic brain tumor cells. The invention provides a method for treating brain tumors by administering genetically engineered neural stem cells in an individual affected by brain tumors. The invention also provides a method of preparing genetically engineered neural stem cells and a composition comprising genetically engineered neural stem cells in a pharmaceutically acceptable carrier.

Abstract: The invention concerns a method for preparing human immunoglobulin concentrates for therapeutic use, from plasma or a plasma fraction. The method comprises pre-purification and a single anion-exchange chromatography carried out at alkaline pH, thereby enabling the immunoglobulins to be retained on the chromatographic support and fractionated. The method enables to obtain IgG, IgA and IgM concentrates.

Abstract: The main object of the present invention is to provide polysaccharide-coated antigens derivatised with lectins for pharmaceutical use. In the vaccines, polysaccharides are preferably selected from the group consisting of chitosan, low-molecular-weight and high-deacetylation-degree chitosan, methyl glycol. chitosan, alginic acid, polymannuronic acid and salts or derivatives thereof. In the vaccines of the invention, antigens are microorganisms, infectious agents or constituents thereof, hormones, enzymes, proenzymes, narcotics, bioactive peptides, metabolites, biological precursors, cell constituents, allergens, and the lectins are of vegetable origin.

Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.

Abstract: Carriers for drug delivery, methods of making such carriers and for associating them to drugs, the resulting carrier and drug combination and methods for drug delivery, particularly controlled or sustained release delivery, using such carrier and drug combinations.

Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.

Abstract: Cosmetic or dermatological preparations, which are finely dispersed systems of the oil-in-water or water-in-oil type, comprising 1. an oil phase, 2. an aqueous phase, 3. boron nitride which has both hydrophilic and lipophilic properties, i.e. has amphiphilic character, and thus positions itself at the water/oil interface, and 4. at most 0.5% by weight of one or more emulsifiers and also optionally comprising further cosmetic or pharmaceutical auxiliaries, additives and/or active ingredients.

Abstract: Novel compositions of matter comprising a foamable delivery system are provided. Novel methods for treating a disease, disorder, or condition using the novel compositions are further provided. Novel methods for making and delivering a foamable pharmaceutical composition are also provided. While the novel compositions and foamable drug delivery system may be utilized for administration of a wide variety of drugs to epithelial tissues, to treat a wide variety of diseases, disorders, or conditions, the inventive compositions and foamable drug delivery systems are particularly useful for the dermatological administration of corticosteroids and antifungal agents.

Abstract: There is provided a method of treating irritations and inflammation of the eye or ear by the topical administration of an aqueous composition containing an inorganic monobasic iodide salt and an oxidizing agent which is buffered to a pH of 4.0 to 8.0. The eye treating compositions have an osmolarity between 140 and 180 mOsm/l and are hypotonic.

Abstract: The invention provides compositions comprising an RAR antagonist for promoting chondrogenesis and methods employing such compositions for treating cartilage and associated bone abnormalities resulting from injury or disease and for ex vivo tissue engineering.

Abstract: A hydrogel for use as a prosthetic device for supplementing, augmenting or replacing cartilage in the intra-articular cavity of a joint and for treatment or prevention of arthritis. The hydrogel may be a polyacrylamide hydrogel obtained by combining acrylamide and methylene bis-acrylamide. A prosthetic device comprising the polyacrylamide hydrogel is also disclosed.

Abstract: A multi-part substitution infusion fluid for an extracorporeal blood treatment and methods for using same are provided. Generally, the multi-part substitution fluid comprises a first solution composed of electrolites but without divalent cations and a second solution comprising divalent cations. Another embodiment includes a third solution comprising a matching citrate/citric acid anticoagulant. The described methods of using the multi-part substitution infusion fluids significantly reduce risks associated with various extracorporeal blood treatments.

Abstract: Mineral additives for preparing tablet compositions that comprise Vitamin E and optionally saw palmetto. The compositions are preferably formulated with a zinc compound and a selenium compound.

Abstract: The present invention features a unique, natural formulation and method of administering the same to treat and prevent diabetes, or rather advances treatment of diabetes, by providing a naturaceutical composition or treatment formulated with one or more processed Morinda citrifolia products as derived from the Indian Mulberry plant. The Morinda citrifolia is particularly adapted to treat Type II diabetes. The Morinda citrifolia product is preferably a leaf extract, but may also be in the form of a juice, a puree juice, a dietary fiber, or other similar forms and is incorporated into various carriers or naturaceutical compositions suitable for in vivo treatment of a patient. The naturaceutical may also combine other food products into the naturaceutical, such as fruit juices, dietary supplements, vitamins and minerals, and others.

Abstract: The invention is directed to chemical processes of preparing fractions from North American ginseng (Panax quinquefolium) and pharmaceutical compositions containing these fractions. The products of the present invention may be used to stimulate the production of cytokines and/or antibodies, or as therapeutics targeted at conditions characterized by low immunity, such as the common cold, influenza, chronic fatigue syndrome, AIDS and cancer.

Abstract: The present invention is a multifunctional nutrient supplement and a process for creating the supplement. The supplement comprises a mixture of lecithin, ginkgo biloba and wheat germ oil. The supplement is made with a five step formation process. The first step of the process uses CO2 supercritical extraction to remove cholesterol, glyceride and fatty acids from an egg yolk. Wheat germ oil is then obtained from dried wheat germ using CO2 supercritical extraction. Gingko biloba is then removed from ginkgo leaves using CO2 supercritical extraction. The egg yolk/lecithin from the first extraction is then combined with the wheat germ oil from the second extraction. Ethanol is then added to the mixture of lecithin and wheat germ oil and low temperature vacuum distilled to create a lecithin and wheat germ oil mixture. The ginkgo biloba extract is then added to the lecithin/wheat germ oil mixture to create the nutrient supplement.

Abstract: The present invention provides a neutral fat reducing composition which reduces a blood neutral fat safely and efficiently, and whose active ingredient is a soybean protein containing 50% or more of a 7S globulin fractionated from a soybean protein and 0.2% or less of phytate based on the proteins. Its effect is further enhanced by removing a oil-body-associated protein and reducing a chloroform methanol-extractable oil fraction.

Abstract: The present invention provides alcoholic beverages which are stabilized against the growth of microorganisms whose growth may cause deterioration of the characteristics of the alcoholic beverages. The stabilized beverages are attained by utilization of a composition which includes a nisin-producing culture and a nutritional supplement in the process of making the alcoholic beverage. The composition of this invention includes nisin at a level effective for inhibiting growth of the spoilage-causing microorganisms, particularly, hardier strains of such microorganisms that may exhibit resistance to lower levels of nisin. The composition is prepared by adding to an aqueous medium, such as wort obtained in the process of making the alcoholic beverage, a nutritional supplement of a type and in an amount that is effective for increasing the yield of nisin, adjusting the pH of the wort to about 6.

Abstract: The present invention relates to a method for producing a fermented dairy product including the use of an oxidase for the conversion of lactose to lactobionic acid. Moreover, it refers to a method for affecting firmness and/or sourness of a fermented dairy product. Hereby is produced a fermented dairy product having improved functional and/or organoleptic properties.

Abstract: Disclosed is a an economical method of efficiently oxygenating yeast slurry without bubble formation. The method employs a membrane oxygenator comprising at least one hydrophobic, microporous membrane having a gas side and a liquid side. The yeast slurry flows over the liquid side of the membrane; oxygen is delivered to the gas side of the membrane and passes through the pores to the yeast slurry.

Abstract: A method and apparatus for marking, imprinting or applying a pattern, design or mark to a plurality of individual pieces of food product to be divided from a sheet of food product is described. In one aspect of the invention, a method may include the steps of supplying a sheet of food product, marking the plurality of individual pieces of food product to be divided from the sheet of food product, and dividing, at least partially, the individual pieces of food product from the sheet of food product. In another aspect of the present invention, an apparatus may generally include a support frame, a cutting plate, and a marking head. The cutting plate preferably includes a plurality of cutting openings and an engagement surface capable of supporting and positioning a sheet of food product. The cutting openings preferably correspond to a plurality of individual pieces of food product to be divided from the sheet of food product.

Abstract: A pasteurization arrangement employs regeneration to bring raw milk or other liquid food product up to a few degrees below a UHT pasteurizing temperature. The product is first heated up by regeneration to about 175° F., and held at this temperature for about sixty seconds to denaturize proteins so that they do not deposit on the heat exchange walls of following stages. Then the product proceeds through a product-product regenerative heat exchanger where it emerges at about 264° and proceeds to a water-product heater to heat the product to 280° F. The water flows in counter current to the product. The temperature differential at any reference point in the heater and the regenerative heat exchanger is below 20°, and the ratio of rate of water flow to product flow in the heater is below about 3:1.

Abstract: A composition for sweetening foodstuffs comprises at least one sweetening agent (e.g., polyol, monosaccharide, disaccharide, trisaccharide, and combinations thereof), and inulin, which comprises at least about 25 percent by weight of the combination of sweetening agent and inulin. A foodstuff comprises a sweetening composition comprising at least one sweetening agent (e.g., polyol, monosaccharide, disaccharide, trisaccharide, and combinations thereof), and inulin, which comprises at least about 25 percent by weight of the combination of sweetening agent and inulin.

Abstract: A savory, shelf-stable, particulate, meltable, food-grade plasticized composition is disclosed, having a water activity Aw of 0.70 or below. The composition is an oil-in-water emulsion of: a protein that forms a thermally reversible meltable gel, plasticizer components to solubilize the protein, comprising a polyol plasticizer and a non-polyol plasticizer, a level of an edible oil component sufficient to provide proper texture, mouthfeel, and melt characteristics to the plasticized composition, and a savory flavoring component, and typically comprises 10–30 wt-% protein, 15–50 wt-% plasticizer component, including, based upon the total weight of the composition, 10–40 wt-% polyol plasticizer and 3–15 wt-% non-polyol plasticizer, 10–40 wt-% oil component, 5–25 wt-% moisture, and 10–40 wt-% flavor characterizing component.

Abstract: The subject of the invention is a fiber-enriched low-calorie drink, characterized in that it comprises 1.5 to 90 g, by dry weight per liter of drink, or branched maltodextrins having between 15 and 35% of 1?6 glucoside linkages, a reducing sugar content of less than 20%, a polymolecularity index of less than 5 and a number-average molecular mass Mn at most equal to 4 500 g/mol, and in that it is stable to acidic pH and/or to heat. The subject of the invention is also the use of branched maltodextrins having between 15 and 35% of 1?6 glucoside linkages, a reducing sugar content of less than 20%, a polymolecularity index of less than 5 and a number-average molecular mass Mn at most equal to 4 500 g/mol, in order to replace all or part of the sugars in a low-calorie drink.

Abstract: Liquid margarines and other pourable dispersions which contain a hardstock fat derived from plant waxes. The fat consists of a mixture of triglycerides, which fat is non-hydrogenated and contains less than 10 wt. % of fatty acid residues with a chain length of 6–10 carbon atoms, of which less than 50 wt. % of the triglycerides consist of monoacyl triglycerides and which fat is characterized in that its content of fatty acid residues which are saturated and contain at least 20 carbon atoms is at least 30 wt. %, preferably at least 40 wt. % and more preferably at least 50 wt. % calculated on total fatty acid residues. Such fat can be obtained by a process comprising the steps: selecting a plant wax, reacting the wax esters from the wax or a reactive derivative of those wax esters with glycerol or with a reactive glycerol derivative, purifying and recovering the obtained triglycerides, optionally admixing the product with a triglyceride fat such that the mixture complies with the above fat definition.

Abstract: A process for manufacturing milk chocolate products containing a higher than normal water content by preparing a dark chocolate containing up to 30% by weight of water, adding a milk powder suspension optionally together with seed crystals of cocoa butter or cocoa butter equivalent, and mixing under low shear. The invention also relates to high water content milk chocolate products, methods of preparing a chocolate coated ice cream article with such products and to the resulting chocolate coated ice cream articles.

Abstract: The invention concerns a novel appetizing agent containing trisodium pyrophosphate combine with a flavour and a taste enhancer, for dry or semi-dry foods for domestic animals, and a method for enhancing appetence of said foods. The invention also concerns a method for increasing and enhancing the taste of flavours and other factors of taste present in domestic animal foods.

Abstract: A testing method for an optical information medium using an artificial fingerprint. The artificial fingerprint is made of an artificial fingerprint liquid comprising a fine-particle-form substance and a dispersion medium capable of dispersing the fine-particle-form substance.

Abstract: A method of manufacturing an organic EL display in which organic EL devices are prevented from being promoted in degradation by interfaces that occur between the hole transporting layer and the luminescent layer and between the luminescent layer and the electron transporting layer during the formation of the organic EL devices. The material of the luminescent layer is evaporated from a first evaporation source. At that time, the first evaporation source is moved from one end of a glass substrate to the other. Consequently, the luminescent layer is formed evenly on the glass substrate. After the formation of the luminescent layer is completed, the material of the electron transporting layer is evaporated from a second evaporation source. The second evaporation source is moved as if the first evaporation source is, whereby the electron transporting layer is formed evenly.

Abstract: A process for producing a hydrophobic silica powder, comprises the steps for hydrophobic treatment of: adding to a silica sol in mixed solvent having a silica concentration of 5 to 50 mass % obtained by mixing an aqueous silica sol containing hydrophilic colloidal silica having a specific surface area of 5.5 to 550 m2/g with a hydrophilic organic solvent in a mass ratio of 0.12 to 2.5 based on water in the aqueous silica sol, a disilazane compound of formula (1) (R13Si)2NH ??(1) wherein each R1 is C1-6alkyl group or phenyl group that is selected independently of one another, in an amount of 0.1 to 20 mmol per surface area 100 m2 of the hydrophilic colloidal silica, to obtain a mixture of the silica sol in mixed solvent and the disilazane compound; and heating the mixture at a temperature of 50 to 100° C. for aging it to obtain a slurry dispersion of hydrophobic treated colloidal silica. The process provides a hydrophobic silica powder through a simple hydrophobic treatment step.

Abstract: Processes for forming a filter material that includes coating a filter particle with a coating comprising a lignosulfonate, carbonizing the coating, and activating the coating. The filter particles may include a variety of filter particles, including but not limited to fibers, granules, and screens, and be formed from a variety of materials, such as metals, metal alloys, carbon, ceramic, or glass. Also, the lignosulfonate-coated filter particles may include a large amount of mesopore and/or macropore volume when carbonized and activated. One exemplary process for forming a filter material includes diluting ammonium lignosulfonate with water, mixing the solution with milled glass fibers, removing the excess lignosulfonate solution from the fibers, drying the lignosulfonate coated glass fibers at 65° C. for 12 h, carbonizing the coated glass fibers in a furnace ramped to 70° C. with a rate of 7° C.

Abstract: A method for installing a constrained layer damper on a product of manufacture is disclosed. The method includes applying a layer of first polymeric material to a substrate of the product, wherein the first polymeric material is visco-elastic when solidified. Then, a second layer of polymeric material, which is stiff when solidified, is applied to the first polymeric material such that said first polymeric material is constrained between the second polymeric material and the substrate of the product. At least one of the layers of polymeric materials is dispensed in fluid form during the manufacture of the product from a bulk source of fluid material. The polymeric materials are chosen such that they do not require the application of heat above room temperature to solidify.

Abstract: Systems and methods for dispensing an anti-traction, mobility denial material on a target surface. In various exemplary embodiments, a method of dispensing an anti-traction material on a target surface includes providing a polymer particle powder to a first section of a dispensing nozzle, providing a water stream to a second section of a dispensing nozzle, and mixing the polymer particle powder with the water stream upon exit of the streams out of the first and second sections of the dispensing nozzle to form the anti-traction material on the target surface, the formed anti-traction material being a gel.

Abstract: A powdery layer is formed on a first side of a web (W) which serves as a substrate by applying electrically charged particles on the web while a rotating grounding electrode is located at a second side of the web.

Abstract: A method for preliminary treatment of particles of a powder in a dry surface treatment process before applying the powder particles on a surface of a substrate by utilizing an electric field created by electrodes. The Electrodes are located at opposite sides of the substrate in such a way that at least one first electrode is located at the side of the substrate to be coated, and at least one second electrode is located at the opposites side of the substrate. The particles of the powder are pre-charged before bringing them into the electric field.

Abstract: A method to deposit TaN by plasma enhanced layer with various nitrogen content. Using a mixture of hydrogen and nitrogen plasma, the nitrogen content in the film can be controlled from 0 to N/Ta=1.7. By turning off the nitrogen flow during deposition of TaN, a TaN/Ta bilayer is easily grown, which has copper diffusion barrier properties superior to those of a single Ta layer or a single TaN layer.

Abstract: Described are matrix liquid crystal displays having two plane parallel support plates which together with a frame form a cell, integrated non-linear elements for switching individual picture elements on the support plates and a nematic liquid crystal mixture which is present in the cell and has a positive dielectric anisotropy and high resistivity. The liquid crystal mixture has a nematic phase range of at least 60° C., a maximum viscosity at 20° C. of 30 mPa·s and a mean dielectricity constant ??8. The liquid crystal mixture contains: a) at least 10% by weight of a liquid-crystalline component B having one or more compounds of the following formulae: and b) up to 90% by weight of a liquid-crystalline component A having one or more compounds with a dielectric anisotropy of ?1.5 to 1.

Abstract: The present invention relates to a method of temporarily and firmly fixing two solids to each other and to a composition used in the method, which is a method of temporarily fixing, comprising temporarily fixing the two solids to each other with a liquid crystal compound or a composition comprising the liquid crystal compound. This method is used for a method of temporarily fixing a pad for chemical mechanical polishing, for example, to polish a wafer for a semiconductor device fixed on a surface of a base plate, when one solid is a pad for chemical mechanical polishing of a wafer for a semiconductor device and the other is a base plate to fix the pad.

Abstract: The present invention broadly comprises a construction material constructed from a plurality of flexible strips, the strips are helically wound upon one another to form a tire pole. The tire pole may incorporate bolts, nails, screws and polymers for securing the flexible strips to one another. The construction material is generally constructed from discarded tires and may comprise a utility pole, a guardrail, a signpost and may be suitable for many other construction applications.