Abstract: A continuous polymerization process for producing reactive polymers comprises continuously charging into a first reaction zone at least one functional monomer and polymerizing the monomers to produce a first polymeric product having at least one functional group. This first polymeric product is then continuously directly charged into a second reaction zone together with at least one modifier reactant having a functional group that is complementary to the functional group of the first polymeric product. At least a portion of the modifier reactant reacts with at least one of the functional groups of the first polymeric product to produce a second polymeric product which incorporates at least a portion of the modifier reactant, such that the second polymeric product is a reactive polymer.

Abstract: A method for crosslinking a carboxylated polymer using a triazine crosslinking activator.

Abstract: A tire component comprising a vulcanized rubber, and from about 3 to about 85 parts by weight, per 100 parts by weight rubber, of a filler dispersed within said vulcanized rubber, where the vulcanized rubber includes the vulcanized residue of a thermoplastic-elastomeric block copolymer defined by the formula ?-?-?-? where ? is a hydrogen atom or a functional group, ? includes an elastomeric block, ? includes a thermoplastic block, and ? includes a hydrogen atom or a functional group.

Abstract: The invention relates to the use of block copolymers as leveling agents for surface coatings, having a weight-average molecular weight of from 1000 to 100000. The leveling agent is a linear or branched block copolymer composed of a polysiloxane block and one or more blocks prepared from ethylenically unsaturated monomers by controlled free-radical addition polymerization. The invention also relates to coating compositions which comprise the leveling agent.

Abstract: A composition useful as a matrix for fiber-reinforced composites possesses a viscosity at 25° C. of no more than 1000 mPa·s and provides a cured product displaying a breaking elongation of at least 5%. The composition comprises (A) at least one of a bisphenol epoxy resin (A1) and a phenol novolak epoxy resin (A2), a polyvalent epoxy resin formed from a mononuclear aromatic backbone (B), an aromatic amine curing agent (C), and a rubber (D).

Abstract: A golf ball, typically its core, is manufactured by molding and vulcanizing a rubber composition comprising a base rubber, an unsaturated carboxylic acid or a metal salt thereof, an inorganic filler, an organic peroxide, and an organosulfur compound. The base rubber contains a polybutadiene having a Mw of 60–150×104 and a Mw/Mn of up to 2.0 and containing at least 98% of cis-1,4 bonds and up to 1.5% of trans-1,4 bonds. The composition is easy to mold and work, and the golf ball has good rebound and improved flight performance.

Abstract: Resins comprising a relatively high-density, low-molecular-weight polyethylene component and a relatively low-density, high-molecular-weight ethylene copolymer component and methods of making the resins are disclosed. The rheological polydispersity of the high-density component exceeds that of either the resin or the low-density component. The resins are valuable for making films, sheets, coatings, pipes, fibers, and molded articles having a favorable balance of good stiffness and excellent environmental stress crack resistance.

Abstract: Compositions containing oxetane compounds having ester, amide, urea, carbamate, carbonate, or carbonyl functionality one carbon atom removed from the oxetane ring cure at high temperatures are suitable for use as underfill materials within a semiconductor package, particularly in applications using lead free solder electrical interconnections.

Abstract: A two-step catalyst preparation method is disclosed. First, a support is combined with an indenoindolyl Group 3-10 metal complex and a first activator comprising an alkyl alumoxane to give a supported complex. The supported complex is subsequently combined with a second activator comprising an ionic borate to produce a borate-treated supported complex. Activating indenoindolyl metal complexes in this sequence surprisingly provides an exceptional activity boost compared with other ways of activating them with either or both types of activators.

Abstract: An object of the present invention is to provide a boron-containing compound capable of forming an ion-conductive polyelectrolyte having high ion-conductive properties, and a polymer of said compound.

Abstract: The disclosure is directed to a partially hydrogenated ring-opened polynorbornene and a process for making the same. The ring-opened polynorbornene is low in birefringence, high in wavelength dependency about birefringence and excellent in transparency and heat resistance.

Abstract: A process for producing an olefin-based copolymer, which comprises copolymerizing at least one olefin selected from the group consisting of ethylene and straight chain ?-olefins, and a vinyl compound (I) and a polyene (II) described below: Vinyl compound (I); a vinyl compound represented by the general formula CH2?CH—R, wherein the substituent R is a saturated hydrocarbon group and steric parameters Es and B1 of the substituent R are respectively ?1.64 or less and 1.53 or more; and Polyene (II); a compound having two or more of ethylene bonds and at least one combination of two ethylene bonds in which those are bonded to each other through at least three carbon atoms.

Abstract: A coating composition is described comprising a multi-stage emulsion polymer that is both radiation curable, removable and includes chemically reactive functional groups in the coating that react with one or more conventional chemical stripping agents, effecting the removal of the coating from a substrate. The UV curable and removable composition is included within one or more layers applied on top of a substrate or on top of a base coat that itself is disposed on top of a substrate.

Abstract: The present invention is a method of producing a (meth)acrylic acid based water-soluble polymer having a content of groups in neutralized state of not more than 90 mole percent, where the sum total of acid groups and groups in neutralized state contained in the (meth)acrylic acid based water-soluble polymer is taken as 100 mole percent, which comprises a photopolymerization step of polymerizing a monomer component by irradiating near-ultraviolet rays to a reaction mixture, the said reaction mixture comprising the monomer component, a photopolymerization initiator, a chain transfer agent and a polymerization solvent, the said monomer component containing not less than 50 mole percent of a (meth)acrylic acid monomer, with the whole monomer component subjected to polymerization being taken as 100 mole percent, and a concentration of the said monomer component in the reaction mixture at the time of polymerization being 40 to 97% by mass.

Abstract: An acrylic copolymer consisting of a first acrylic monomer represented by the following general formula (1): [where each of R1 and R2 represents an aliphatic hydrocarbon group whose main chain is composed of 3 or less carbon atoms, and each of R3 and R4 represents a hydrocarbon atom], and a second acrylic monomer represented by the following general formula (2): [where at least one of R5 and R6 represents an aliphatic hydrocarbon group whose main chain is composed of 4 to 60 carbon atoms, in the case where one of the R5 and R6 does not represent the aliphatic hydrocarbon group, it represents an aliphatic hydrocarbon group whose main chain is composed of 3 or less carbon atoms, and each of R7 and R8 represents a hydrogen atom], wherein the first acrylic monomer makes up 50 to 99 % of total monomer units in the copolymer.

Abstract: The present invention is directed to a free radical control agent of the structural formula: wherein R1 is a divalent alkyl group of 1 to 12 carbon atoms, R2 and R3 are each independently hydrogen or an alkyl group of 1 to 12 carbon atoms, and R4 is —OH or —COOH, with the proviso that the total carbon atoms of R1, R2, and R3 is no greater than 12; and wherein Y represents a functional group that is capable of activating a vinylic carbon toward free radical addition.

Abstract: A process for the preparation of urethane resins, which comprises the steps of: preparing a product(A) having a hydrolysable group directly bonded to 1–10 silicon atoms and having less than two secondary amino groups in one molecule; preparing a product(B) having a terminal isocyanate group in an amount 4% or less by weight of said product(B); and reacting said product(A) with said product(B) in proportions of at least 0.5 equivalent of the product(A) per free NCO group of said product(B). The process can readily give urethane resins which exhibit excellent storage stability and are enhanced in the degrees of freedom of physical properties of products of curing.

Abstract: The present invention relates to miscible blends of the polycarbonate of bisphenol A and polyesters from aromatic dicarboxylic acids, 1,4-cyclohexanedimethanol, ethylene glycol, and 2,2?-(sulfonylbis(4,1-phenyleneoxy)-bis(ethanol).

Abstract: The present invention provides novel block copolycarbonates comprising residues from a hydroxy terminated polyetherimide or polyimide, residues from a dihydroxy compound, and residues from an activated carbonate. In a preferred embodiment of the present invention the polyetherimide or polyimide blocks exhibit high Mw while the resulting block copolycarbonate exhibits a single Tg. The novel block copolycarbonates of the present invention are produced under melt polymerization conditions in the presence an activated carbonate source.

Abstract: In the present invention, a masterbatch is produced by melt-mixing a metal compound (B) with a reactive thermoplastic resin (C). The oxidizable polyamide (A) is produced by polycondensing a diamine component containing m-xylylenediamine in an amount of 70 mol % or higher with a dicarboxylic acid component containing adipic acid in an amount of 50 mol % or higher. The metal compound (B) contains at least one metal selected from the group consisting of transition metals in group VIII of the periodic table, manganese, copper and zinc. The reactive thermoplastic resin (C) has an internal bond and/or a reactive functional group which are reactive with an amide bond and/or a reactive functional group of the oxidizable polyamide (A). The masterbatch exhibits a stable moldability. The masterbatch is melt-mixed with an oxidizable polyamide (A) and formed into a molded article which exhibits an excellent oxygen-absorbing ability irrespective of the preservation conditions of the masterbatch.

Abstract: The invention provides water-soluble compounds that include a polymer and at least one terminal azide or acetylene moiety. Also provided are highly efficient methods for the selective modification of proteins with PEG derivatives, which involves the selective incorporation of non-genetically encoded amino acids, e.g., those amino acids containing an azide or acetylene moiety, into proteins in response to a selector codon and the subsequent modification of those amino acids with a suitably reactive PEG derivative.

Abstract: This invention relates to a polymer having a chain structure of a repeating unit of a proton-conducting compound which causes an electrochemical redox reaction in a solution of a proton source to act as an electrode active material, and a heterocyclic compound structure; and an electrochemical cell comprising the polymer as an electrode active material.

Abstract: The present invention is generally directed to copolymers of fluorene. It further relates to devices that are made with the copolymers.

Abstract: A method for polymerizing electronic and photonic polymers, wherein an aromatic monomer is combined with a hematin catalyst derivatized with at least one non-proteinaceous amphipathic group, and a peroxide initiator, and employing a template, wherein the aromatic monomer aligns along the template and polymerizes to form a complex comprising the polymerized monomer and the template.

Abstract: A method for site-selective acyl transfer in amidation of folded polypeptides and proteins based on the use of a chemical structure element comprising an imidazole function, such as histidine, in position i flanked by at least one functional group to be amidated, such as lysinc, in position i+3+4k. where K is an integer equal to or higher than ?1, or in position i?4?4n, wherein n is an integer equal to or higher than 0, and at least one activating group, such as serine, in position i+4+4n or i?3?4n, respectively.

Abstract: The present invention relates to sperm specific surface proteins, nucleic acid sequences encoding those proteins and antibodies raised against those proteins. Compositions comprising the sperm specific proteins or inhibitors of said proteins can be used in contraceptive applications.

Abstract: Peptide inhibitors of dipeptidyl-aminopeptidase type IV (DP-IV) are provided. The peptide inhibitors have an isomeric purity of about 96–99 percent. The peptide inhibitors include one or more amino acids covalently coupled to boroproline moiety. The compounds are useful as DP-IV inhibitors, in vivo and in vitro.

Abstract: This invention relates to novel Eimeria proteins with immunogenic properties as well as to DNA sequences encoding these proteins. These proteins can be administered to poultry thereby protecting the birds against coccidiosis. In addition the DNA encoding these proteins can be used for the preparation of a vector vaccine against coccidiosis.

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Abstract: A novel, soluble protein similar to the known Toll-like receptor (TLR) family is disclosed. The present invention relates to these new soluble polypeptides, to nucleotide sequences encoding the polypeptides, to antibodies selectively binding to the polypeptide and to expression systems suitable for producing the polypeptide. The polypeptide is useful for modulating inflammatory reactions in mammals that include the actions of TLR.

Abstract: It is intended to provide an anti-allergic agent, which efficaciously relieves symptoms accompanying an allergic disease without causing any serious side effect. This object is achieved by providing an anti-allergic agent which contains, as an effective ingredient, proteins collected from royal jelly or purified royal jelly, or royal jelly or purified royal jelly containing the proteins.

Abstract: The subject invention provides new fluorescent and/or colored proteins, and polynucleotide sequences that encode these proteins. The subject invention further provides materials and methods useful for expressing these detectable proteins in biological systems.

Abstract: A conjugate exhibiting interferon gamma activity and comprising at least one first non-polypeptide moiety covalently linked to an IFG polypeptide, the polypeptide comprising an amino acid sequence that differs from that of a parent IFNG polypeptide in at least one introduced and/or at least one removed amino acid residue comprising an attachment group for the non-polypeptide moiety. The conjugate may be used for treatment of various diseases.

Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Abstract: This invention relates to novel humanized and other recombinant or engineered antibodies or monoclonal antibodies to the vitronectin ?v?3 receptor and to the genes encoding same. Such antibodies are useful for the therapeutic and/or prophylactic treatment of ?v?3-mediated disorders, such as restenosis, in human patients.

Abstract: Multivalent, multispecific molecules having at least one specificity for a pathogen and at least one specificity for the HLA class II invariant chain (Ii) are administered to induce clearance of the pathogen. In addition to pathogens, clearance of therapeutic or diagnostic agents, autoantibodies, anti-graft antibodies, and other undesirable compounds may be induced using the multivalent, multispecific molecules.

Abstract: The present invention relates to an antibody or antibody fragment that binds to 1,4,7,10-tetrazacyclododecane-N,N?,N?,N??-tetraacetic acid (DOTA),which is bound to an alkyl-amino group through one of its pendant carb.oxyl groups.

Abstract: The invention is a method of identifying the presence of a disease state in a mammal which is associated with degradation of connective tissue in the mammal which contains the protein known as YKL-40. The method is a competitive immunoassay for YKL-40. It can be used, for example, to identify the presence of inflammatory or degenerative joint disease and tumor metastasis (to the extent it can be correlated to serum YKL-40 levels). Serum YKL-40 levels as detected and quantified by the inventive method are also suggestive of the prognosis for the length of survival in breast cancer patients following recurrence and/or metastasis of their cancers.

Abstract: The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to P. aeruginosa mucoid exopolysaccharide. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of P. aeruginosa infection and related disorders (e.g., cystic fibrosis). Some antibodies of the invention enhance opsonophagocytic killing of multiple mucoid strains of P. aeruginosa. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.

Abstract: The invention discloses compounds and compositions for dual phototherapy and combined therapy and diagnosis of tumors and other lesions. The compounds have a Dye that, when photoactivated, operates via Type I and/or Type II mechanisms. Other Dye or azide components may operate by the same or different mechanisms. Selection of particular components in a compound, and formulation of the compound(s) in a composition permit different activation wavelengths to be used for different therapies. A targeting moiety may be added to the compound or composition so that the Dye locates at a particular site, such as a hormone-sensitive tumor, for diagnosis and/or treatment. The compounds and compositions may be incorporated within liposomes.

Abstract: The present invention provides methods for modulating the growth and/or yield of plants. In particular the methods comprise the use of agents which functionally inhibit the expression of plant D-like cyclin inhibitors including isolated polynucleotide sequences which interact with DNA or RNA encoding proteins capable of binding plant D-like cyclins. Further, the present invention provides recombinant polynucleotide sequences, vectors and host cells which encode proteins capable of binding to and inactivating the activity of plant D-like cyclin/cyclin dependent kinase complexes preventing plant cells from exiting the cell cycle. Methods for determining and agents which are inhibitors of the BRO cyclin dependent kinase inhibitor proteins which are capable of modulating plant cell cycle progression are also provided. Methods for the production of transgenic plant cells and plants with increased growth rates and yields when compared to wild-type plants are also provided.

Abstract: The preparation and use of nucleic acid fragments encoding plant fatty acid modifying enzymes associated with modification of the delta-9 position of fatty acids, in particular, formation of conjugated double bonds are disclosed. Chimeric genes incorporating such nucleic acid fragments and suitable regulatory sequences can be used to create transgenic plants having altered lipid profiles. The preparation and use of nucleic acid fragments encoding plant fatty acid modifying enzymes associated with formation of a trans delta-12 double bond also are disclosed. Chimeric genes incorporating such nucleic acid fragments and suitable regulatory sequences can be used to create transgenic plants having altered lipid profiles.

Abstract: The present invention provides a noveal isolated and purified nucleic acid molecule having a nucleotide sequence that in nature directs transcription of CTP:phosphocholine cytidylyltrransferase (CCT), i.e., is a novel CCT promoter, and methods of use thereof.

Abstract: A unimolecular probe for hybridization to a molecule comprising a target nucleic acid sequence, the probe includes: a first nucleic acid sequence complementary to the target sequence (target-binding sequence); a second nucleic acid sequence complementary to a portion of the first nucleic acid sequence and capable of hybridization therewith to form a first intramolecular duplex. In use, the target and target-binding sequence hybridize to form a duplex. A probe can be used to detect a molecule containing the target sequence, act as a primer for synthesis or amplification, etc.

Abstract: The conditions under which oligonucleotide probes hybridize preferentially with entirely complementary and homologous nucleic acid targets are described. Using these hybridization conditions, overlapping oligonucleotide probes associate with a target nucleic acid. Following washes, positive hybridization signals are used to assemble the sequence of a given nucleic acid fragment. Representative target nucleic acids are applied as dots. Up to to 100,000 probes of the type (A,T,C,G)(A,T,C,G)NB(A,T,C,G) are used to determine sequence information by simultaneous hybridization with nucleic acid molecules bound to a filter. Additional hybridization conditions are provided that allow stringent hybridization of 6–10 nucleotide long oligomers which extends the utility of the invention. A computer process determines the information sequence of the target nucleic acid which can include targets with the complexity of mammalian genomes.

Abstract: The present invention provides novel antisense ribozymes useful for inhibiting the activity of neutral sphingomyelinase. Also provided are methods for reducing the activity of neutral sphingomyelinase, as well as methods for reducing apoptosis and atherosclerosis using the ribozymes of the invention.

Abstract: A solid support bound polynucleotide, preferably a 3?-O- or 5?-O-substituted polynucleotide, is disclosed. The polynucleotides are of formula: wherein Q is a substantially pure polynucleotide, each X is O or S; Y is an inert spacer group; R represents the solid support. Also disclosed is a method of isolating a target biomolecule, preferably a protein or a polynucleotide, from a mixture.

Abstract: The present invention relates to novel compounds, the use of said compounds as a medicament as well as for the manufacture of a medicament for treatment of disorders relating to the binding of galectin to receptors in a mammal. Said galectin is preferably a galectin 3.

Abstract: A process for preparation of 7-[D-?-amino-?-(4-hydroxyphenyl)acetamido]-3-(1-propen-1-yl)-3-cephem-4-carboxylic acid viz. Cefprozil of formula (I) in high purity, substantially free of impurities, which comprises preparation of mixed acid anhydride by selecting the sequence and temperature of addition of the reagents and its subsequent condensation with a protected 7-APCA; followed by hydrolysis, isolation and purification to give Cefprozil of formula (I) in the form of a monohydrate.