Patents Issued in October 2, 2007
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Patent number: 7276304Abstract: A fuel cell system with improved electrical isolation having a fuel cell stack with a positive potential end and a negative potential, a manifold for use in coupling gases to and from a face of the fuel cell stack, an electrical isolating assembly for electrically isolating the manifold from the stack, and a unit for adjusting an electrical potential of the manifold such as to impede the flow of electrolyte from the stack across the isolating assembly.Type: GrantFiled: December 23, 2004Date of Patent: October 2, 2007Assignee: FuelCell Energy, Inc.Inventors: Dana A. Kelley, Mohammad Farooque, Keith Davis
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Patent number: 7276305Abstract: A method of operating a fuel cell including a fuel electrode, an oxidant electrode, and an electrolyte layer having hydrogen ion conductivity sandwiched between the fuel electrode and the oxidant electrode, so that the fuel cell generates electricity as a result of an electrochemical reaction between a fuel and an oxidant. Each time the fuel cell is started from a non-operating condition, the fuel is supplied to the fuel electrode with the fuel electrode and the oxidant electrode electrically interconnected to produce hydrogen at the oxidant electrode by provoking electrochemical reactions expressed by the chemical equations H2?2H++2e? and 2H++2e??H2 at the fuel electrode and the oxidant electrode, respectively, reducing oxides on the oxidant electrode, using the hydrogen produced at the oxidant electrode. Then, the oxidant is supplied to the oxidant electrode to begin normal continuing operation of the fuel cell.Type: GrantFiled: February 1, 2006Date of Patent: October 2, 2007Assignee: Mitsubishi Denki Kabushiki KaishaInventors: Hisatoshi Fukumoto, Hironori Kuriki, Takashi Nishimura, Shuichi Matsumoto
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Patent number: 7276306Abstract: Described herein is a system for the co-generation of hydrogen gas and electricity, wherein the proportion of hydrogen to electricity can be adjusted from 0% to 100%. The system integrates fuel cell technology for power generation with fuel-assisted steam-electrolysis. A hydrocarbon fuel, a reformed hydrocarbon fuel, or a partially reformed hydrocarbon fuel can be fed into the system.Type: GrantFiled: March 12, 2003Date of Patent: October 2, 2007Assignee: The Regents of the University of CaliforniaInventors: Ai Quoc Pham, Brian Lee Anderson
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Patent number: 7276307Abstract: A cogeneration fuel cell system and associated methods of operation are provided that accommodate a demand for heat as well as a demand for electric power. The system is operated among various modes to balance heat and power demand signals. In general, a fuel cell system is coupled to a power sink and a heat sink, and a controller is adapted to respond to data signals from the power sink and the heat sink. As examples, such data signals from the heat sink may include a temperature indication or a heat demand signal (such as from a thermostat), and such data signals from the power sink may include a voltage or current measurement, an electrical power demand signal, or an electrical load.Type: GrantFiled: September 6, 2005Date of Patent: October 2, 2007Assignee: Plug Power Inc.Inventors: Arne W. Ballantine, Ryan Hallum, John W. Parks, Dustan L. Skidmore
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Patent number: 7276308Abstract: A fuel cell system that employs a recuperative heat exchanger to provide additional cooling for the compressed charge air applied to the cathodes of the fuel cells in the fuel cell stack. The cathode exhaust gas is applied to the recuperative heat exchanger so that the cathode exhaust gas cools the charge air heated by the compressed air. A cathode exhaust gas expander is provided in combination with the recuperative heat exchanger that uses the energy in the heated cathode exhaust gas to power the charge air compressor. An anode exhaust gas combustor can be provided that burns residual hydrogen in the anode exhaust gas to further heat the cathode exhaust gas before it is applied to the expander.Type: GrantFiled: October 29, 2003Date of Patent: October 2, 2007Assignee: General Motors CorporationInventors: Volker Formanski, Thomas Herbig, George R. Woody, John P. Salvador, Steven D. Burch, Uwe Hannesen
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Patent number: 7276309Abstract: Improved fuel cell systems comprise a fuel delivery system having a fluidization apparatus and a fluidization pump for creating an electrolyte flow suitable for fluidizing at least a portion of the fuel particles located within the fluidization apparatus. Due to the presence of the fluidization pump and the fuel delivery pump, the degree of fluidization of the fuel particles can be controlled independently of the overall electrolyte flow rate provided to the cell stacks. In other words, the mass flow rate of fuel particles through the fuel cell can be varied independently from the total flow rate through the fuel cell system. The fluidization of fuel particles can facilitate suitable mixing of fuel particles and electrolyte and can prevent fuel particle agglomeration, which can clog the fuel cell piping system.Type: GrantFiled: September 12, 2003Date of Patent: October 2, 2007Assignee: Teck Cominco Metals, Ltd.Inventors: Kent I. Smedley, Ronald Gulino, Donald James Novkov, Ethan T. Alger, Jesse Rosen, Stuart I. Smedley
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Patent number: 7276310Abstract: A configuration of an electrolyte membrane for a fuel cell is provided, which can be sealed reliably and easily between the separators. The sealing configuration is between the separators and between a peripheral portion of the electrolyte membrane and the respective separators. The sealing configuration includes a frame having an elastic modulus of greater than about 2,000 MPa and less than about 2,000,000 MPa and an elastic body having an elastic modulus of greater than 0 MPa and less than about 200 MPa. In one embodiment, the separators or portions thereof may themselves constitute the at least one elastic body. In another embodiment, the electrolyte membrane may be held by two frames lying on opposite sides of the electrolyte membrane, with the at least one elastic body arranged between the first and second frames sandwiching the membrane and also between the frames and the respective separators.Type: GrantFiled: April 2, 2004Date of Patent: October 2, 2007Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Susumu Kobayashi, Toshihiro Matsumoto, Takeshi Tomizawa, Katsuzou Kokawa, Teruhisa Kanbara
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Patent number: 7276311Abstract: The present invention provides a polymer electrolyte fuel cell capable of eliminating condensate water, and preventing flooding due to an excessively humidified electrode by a simple structure and easy processing composition. A fuel cell comprising a plurality of stacked cells where separators having respectively a fuel gas passage or an oxidant gas passage formed on the surface thereof are opposed to a fuel electrode or an air electrode and an electrolyte membrane is arranged between the fuel electrode and the air electrode, in which a drainage means is disposed downstream the middle of the fuel gas passage or oxidant gas passage. In addition, a temperature adjustment means for adjusting the temperature of the fuel or the oxidant is provided at least at one point in the path from the supply inlet to the discharge exit of at least one passage of fuel electrode side or the air electrode side.Type: GrantFiled: August 29, 2002Date of Patent: October 2, 2007Assignee: Sanyo Electric Co., Ltd.Inventors: Takashi Yasuo, Akira Hamada, Hirokazu Izaki, Shuuichi Suzuki, Kunihiro Nakato, Yasuo Miyake
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Patent number: 7276312Abstract: To provide novel devices constituting light detection systems with a simple configuration, a low maintenance cost, a reduced size and weight, and high reliability by integrating light detection components and power supplies. A photosensitive solid-state thin-film lithium-ion secondary cell including a photosensitive negative-electrode active material layer as a component, wherein extraneous light can be constantly detected by utilizing a change in open-circuit voltage of the cell caused when the extraneous light is incident on the photosensitive negative-electrode active material layer. Lithium ions can be readily received and emitted and light in a broad wavelength range over a near-infrared light range, the entire visible light range, and a near-ultraviolet light range can be detected by utilizing a porous silicon layer having a controlled porosity as the negative-electrode active material layer.Type: GrantFiled: December 26, 2003Date of Patent: October 2, 2007Assignee: Japan Science and Technology AgencyInventor: Mamoru Baba
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Patent number: 7276313Abstract: A battery comprises at least two unit cells. Each of the at least two unit cells is provided with an outer sheath film composed of polymer-metal composite material, a positive-electrode current collector, a negative-electrode current collector, a separator disposed between the positive-electrode current collector and the negative-electrode current collector, one positive electrode tab to which the positive-electrode current collector is connected and protruding from a first sealed portion of the outer sheath film, one negative electrode tab to which the negative-electrode current collector is connected and protruding from a second sealed portion of the outer sheath film, a first polymer layer disposed between the positive electrode tab and the outer sheath film, and a second polymer layer disposed between the negative electrode tab and the outer sheath film.Type: GrantFiled: April 22, 2003Date of Patent: October 2, 2007Assignee: Nissan Motor Co., Ltd.Inventors: Kyoichi Watanabe, Hideaki Horie, Hiroshi Sugawara, Takaaki Abe, Osamu Shimamura, Yuuji Tanjou, Takanori Itou
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Patent number: 7276314Abstract: The present invention is a secondary battery having a high specific capacity and good cycleability, and that can be used safely. The secondary battery is manufactured to include an anode formed from a host material capable of absorbing and desorbing lithium in an electrochemical system such as a carbonaceous material, and lithium metal dispersed in the host material. The freshly prepared anodes of the invention are combined with a positive electrode including an active material, a separator that a separates the positive electrode and the negative electrode, and an electrolyte in communication with the positive electrode and the negative electrode. The present invention also includes a method of preparing a freshly prepared anode and a method of operating a secondary battery including the anode of the invention.Type: GrantFiled: January 16, 2004Date of Patent: October 2, 2007Assignee: FMC CorporationInventors: Yuan Gao, John L. Burba, III
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Patent number: 7276315Abstract: Design methods and a computer-readable medium having computer-executable instructions thereon for sidelobe suppression in a radiation-patterning tool or mask. Sidelobe artifacts are mitigated by identifying elements as a function of the radiation wavelength for forming desired profiles on a semiconductor wafer. A diffraction ring is calculated around each of the elements to identify sidelobe interference zones and intesections of diffraction rings are located. When a guard ring around one of the intersections would otherwise overlap with a guard ring around another one of the intersections, a common sidelobe inhibitor is located at the common overlap region of the guard rings. A method for forming a mask with the addition of sidelobe inhibitors as well as a method for determining the location of placement of sidelobe inhibitors is also disclosed.Type: GrantFiled: June 27, 2003Date of Patent: October 2, 2007Assignee: Micron Technology, Inc.Inventors: William A. Stanton, Husayn Alvarez-Gomariz
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Patent number: 7276316Abstract: A method of making an embedded attenuated phase shift mask (EAPSM) comprises initially providing a phase shift mask substrate having a layer of phase shifting material and a layer of an opaque material, and depositing a first resist layer on the substrate. The first resist layer is exposed by a direct write electron beam or laser energy source and developed, and the substrate is etched, to create first level phase shifting image segments on the substrate corresponding to areas of critical structures to be exposed with the EAPSM. The method then includes depositing a second resist layer on the substrate. Using a single frame exposure mask corresponding to non-critical areas outside the critical structure areas, the second resist layer is then exposed by simultaneous projection exposure. The method then includes developing the second resist layer and etching the substrate to remove the opaque material from the critical structure areas.Type: GrantFiled: February 2, 2004Date of Patent: October 2, 2007Assignee: International Business Machines CorporationInventor: Andrew J. Watts
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Patent number: 7276317Abstract: A laser mask and method of crystallization using the same that can produce a polycrystalline silicon thin film having uniform crystallization characteristics. According to the present invention, a method of crystallization using a laser mask having a reference pattern in a first block and the reverse pattern of the reference pattern in a second block includes providing a substrate having a silicon thin film; positioning the first block of the laser mask over a portion of the silicon film and irradiating a first laser beam through the first block; and moving either the laser mask or the substrate to position the second block of the laser mask over the portion of the silicon film and irradiating a second laser beam through the second block.Type: GrantFiled: December 14, 2004Date of Patent: October 2, 2007Assignee: LG.Philips LCD Co., Ltd.Inventor: JaeSung You
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Patent number: 7276318Abstract: This invention relates to an electrophotographic photosensitive member having a support and a photosensitive layer.Type: GrantFiled: November 5, 2004Date of Patent: October 2, 2007Assignee: Canon Kabushiki KaishaInventors: Atsushi Fujii, Masato Tanaka
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Patent number: 7276319Abstract: A toner for electrostatic latent image development includes a coloring agent and a resin wherein the toner is formed by a polymerization method and a content of aromatic amine contained in the toner is 50 ppm or less, and a volume average particle size of the toner is 3 to 8 ?m; and an image forming method employs the same toner.Type: GrantFiled: March 11, 2004Date of Patent: October 2, 2007Assignee: Konica Minolta Holdings, Inc.Inventors: Naohiro Hirose, Asao Matsushima, Shiro Hirano, Hiroshi Yamazaki
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Patent number: 7276320Abstract: A method of forming toner particles having surface particles attached thereto includes the steps of aggregating a material of at least one binder material and at least one colorant to produce toner particles, following aggregation, forming a mixture of the surface particles and the toner particles, and subjecting the mixture to a temperature above the glass transition temperature of the toner particles to coalesce the toner particles, whereby the surface particles become at least partially embedded within the surface of the toner particles. Toner particles prepared by such method include a core comprised of at least one binder and at least one colorant, and surface particles at an external surface of the toner particles, wherein at least about 50% of the surface particles are substantially completely covered by a portion of binder and a majority of the surface particles protrude from the toner particle surface a distance of at least 50% of the average particle size of the surface particles.Type: GrantFiled: January 19, 2005Date of Patent: October 2, 2007Assignee: Xerox CorporationInventors: Grazyna E. Kmiecik-Lawrynowicz, Maura A. Sweeney, Robert D. Bayley, Ronald J. Koch, Mary L. McStravick, Daniel W. Asarese
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Patent number: 7276321Abstract: Photo toners including a wax-like compound of the formula (I), detailed in the specification. In formula (I), R1 represents the group —CH2—O—CO—R3 or CH(OH)—CH2—O—CO—R3, R2 represents an alkyl radical comprising between 1 and 4 C atoms or halogen, R3 represents an unbranched alkyl radical comprising between 16 and 36 C atoms, m is 1, 2 or 3, and n is between 0 and (6?m).Type: GrantFiled: May 20, 2003Date of Patent: October 2, 2007Assignee: Clariant Produkte (Deutschland) GmbHInventors: Gerd Hohner, Michael Bayer
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Patent number: 7276322Abstract: In one method of making an organic electroluminescent device, a transfer layer is solution coated on a donor substrate. The transfer layer includes an amorphous, non-polymeric, organic matrix with a light emitting material disposed in the matrix. The transfer layer is then selectively patterned on a receptor. Examples of patterning methods include laser thermal transfer or thermal head transfer. The method and associated materials can be used to form, for example, organic electroluminescent devices.Type: GrantFiled: January 23, 2006Date of Patent: October 2, 2007Assignee: 3M Innovative Properties CompanyInventors: Erika Bellmann, James G. Bentsen, Yong Hsu, Manoj Nirmal, Martin B. Wolk
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Patent number: 7276323Abstract: Photoresists and associated processes for microlithography in the extreme, far, and near UV are disclosed. The photoresists in some embodiments comprise (a) a fluorine-containing copolymer comprising a repeat unit derived from at least one ethylenically unsaturated compound characterized in that at least one ethylenically unsaturated compound is polycyclic and at least one ethylenically unsaturated compound contains at least one fluorine atom covalently attached to an ethylenically unsaturated carbon atom; and (b) at least one photoactive component.Type: GrantFiled: May 14, 2003Date of Patent: October 2, 2007Assignee: E. I. du Pont de Nemours and CompanyInventors: Andrew Edward Feiring, Jerald Feldman
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Patent number: 7276324Abstract: Chemically amplified resist compositions comprising nitrogen-containing organic compounds having an aromatic carboxylic acid ester structure have an excellent resolution and provide a precise pattern profile and are useful in microfabrication using electron beams or deep-UV light.Type: GrantFiled: November 10, 2004Date of Patent: October 2, 2007Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Takeru Watanabe, Takeshi Kinsho, Koji Hasegawa, Katsuya Takemura, Kazumi Noda, Katsuhiro Kobayashi
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Patent number: 7276325Abstract: A composition utilized in and a method for forming an electrode used in field emission type of display devices said composition is a photosensitive copper conductive composition comprising: a mixture of (a) copper powder at least 70 wt % out of 100 wt % copper powders having a particle size in the range of 0.2-3 ?m and (b) an inorganic binder with a softening point in the range of 380-580° C. in an amount of 1-40 wt % based on 100 wt % copper powders, said mixture being dispersed in an organic vehicle comprising (c) an organic polymer binder, (d) a phototoinitiator, (e) a photohardenable monomer, and an organic solvent; and the photosensitive copper conductive composition being fireable at a temperature in the range of 450-600° C. in a reductive atmosphere.Type: GrantFiled: December 29, 2005Date of Patent: October 2, 2007Assignee: E.I. duPont de Nemours and CompanyInventor: Keiichiro Hayakawa
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Patent number: 7276326Abstract: A method for manufacturing an organic electroluminescence display includes forming a plurality of first electrodes on a substrate in a shape of stripe; forming a photoresist layer on an entire surface of the substrate; performing a first exposure of a first area on the photoresist layer crossing the first electrodes; carrying out an image reversal of the first exposed photoresist layer; performing a second exposure of a remaining area on the photoresist layer except a second area crossing the first electrodes and a third area between the first electrodes; performing a third exposure of the entire surface of the photoresist layer; and developing the second exposed photoresist layer and the third exposed photoresist layer.Type: GrantFiled: May 11, 2006Date of Patent: October 2, 2007Assignee: Daewoo Electronics CorporationInventors: Kyung Hee Choi, Byung Hyun Byun, Seung Jun Yi
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Patent number: 7276327Abstract: Antireflective compositions characterized by the presence of an Si-containing polymer having pendant chromophore moieties are useful antireflective coating/hardmask compositions in lithographic processes. These compositions provide outstanding optical, mechanical and etch selectivity properties while being applicable using spin-on application techniques. The compositions are especially useful in lithographic processes used to configure underlying material layers on a substrate, especially metal or semiconductor layers.Type: GrantFiled: October 31, 2005Date of Patent: October 2, 2007Assignee: International Business Machines CorporationInventors: Marie Angelopoulos, Wu-Song Huang, Arpan P. Mahorowila, Wayne Moreau, Dirk Pfeiffer, Ratnam Sooriyekumaren
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Patent number: 7276328Abstract: A method of reflective lithography includes directing an asymmetric radiation (light) beam onto a reticle of a reflective lithography system. The asymmetry in the shape of the radiation beam may be used to compensate for a non-zero (non-normal) angle of incidence of the incident radiation. The radiation source shape may be configured to produce a substantially-symmetric output from the reticle. The shape of the radiation source may be configurable by any of a variety of suitable methods, for example by use of a configurable reflective device such as a fly's eye mirror, or by use of one or more suitable mirrors, lenses, and/or slits.Type: GrantFiled: March 2, 2004Date of Patent: October 2, 2007Assignee: Advanced Micro Devices, Inc.Inventors: Cyrus E. Tabery, Bruno M. LaFontaine, Ivan Lavolic
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Patent number: 7276329Abstract: A method of sorting cells, particularly, but not exclusively, sperm cells, is described. The method comprises the use of a surface decontamination medium to strip the cells of any extra-cellular surface contamination and to then subject to stripped cells to a charge based separation.Type: GrantFiled: March 8, 2001Date of Patent: October 2, 2007Assignee: Ovasort LimitedInventor: Ian Cumming
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Patent number: 7276330Abstract: Time dependent iterative reactions are carried out in microscale fluidic channels by configuring the channels such that reagents from different sources are delivered to a central reaction zone at different times during the analysis, allowing for the performance of a variety of time dependent, and/or iterative reactions in simplified microfluidic channels. Exemplary analyses include the determination of dose responses for biological and biochemical systems.Type: GrantFiled: April 17, 2003Date of Patent: October 2, 2007Assignee: Caliper Technologies Corp.Inventors: Calvin Y. H. Chow, J. Wallace Parce
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Patent number: 7276331Abstract: The invention provides isolated nucleic acid and amino acid sequences of Xenopus CENP-E (XCENP-E), antibodies to XCENP-E, methods of screening for CENP-E modulators using biologically active CENP-E, and kits for screening for CENP-E modulators.Type: GrantFiled: August 27, 2003Date of Patent: October 2, 2007Assignee: The Regents of the University of CaliforniaInventors: Kenneth W. Wood, Roman Sakowicz, Lawrence S. B. Goldstein, Don W. Cleveland
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Patent number: 7276332Abstract: The invention is a method for the development of a platform that enables the efficient and simultaneous creation of multiple detection assays. The invention entails the use of any bacteriophage, modified to carry a reporter gene, to which any analyte-recognizing moiety is attached via the capsid. The modified bacteriophage is used to attach to the target analyte. This attachment is identified via bacteriophage amplification in a helper bacteria strain with subsequent production and detection of the reporter gene.Type: GrantFiled: May 23, 2006Date of Patent: October 2, 2007Assignee: University of WyomingInventor: Lawrence Goodridge
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Patent number: 7276333Abstract: The object of the present invention is to provide a screening method of a new integrase inhibitor being able to inhibit an HIV infection before the reverse transcription step and having a pharmaceutical site of action totally different from those of traditional integrase inhibitors, a new integrase inhibitor being obtainable by the screening method, and pharmaceutical constituents containing the integrase inhibitor and DNA encoding the integrase inhibitor being greatly expected as new remedies for AIDS. A peptide which specifically binds to a peptide at N-terminal domain of retroviral integrase was screened by phage display method, and as a result of the screening, a peptide being able to inhibit the infection and the proliferation of retroviruses such as HIV-1 before the reverse transcription reaction is obtained.Type: GrantFiled: April 25, 2000Date of Patent: October 2, 2007Assignee: Japan Science and Technology AgencyInventors: Takao Masuda, Mari Kannagi
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Construction and characterization of monoclonal antibodies against western equine encephalitis virus
Patent number: 7276334Abstract: Construction and characterization of mouse monoclonal antibodies against western equine encephalitis virus (WEE) for potential use in detection, diagnosis, and immunotherapy are disclosed. Antibodies were prepared from hybridoma cells and further characterized by ELISAs, Western blotting, isotyping, and immunoprecipitation. The antibodies were also tested for cross-reactivity to other alphaviruses, such as Sindbis virus (SIN), Venezuelan equine encephalitis virus (VEE), and eastern equine encephalitis (EEE). All antibodies bound to WEE antigen in ELISAs, whereas only a subgroup of antibodies was found to be active in Western blotting and immunoprecipitations. A subset of antibodies was found to cross-react with other alphaviruses, such as SIN, VEE, and EEE.Type: GrantFiled: June 24, 2004Date of Patent: October 2, 2007Assignee: The Minister of Defence, Goverment of CanadaInventor: Leslie P. Nagata -
Patent number: 7276335Abstract: A method for designing compounds specifically targeting RNA sequences, based on the discovery of short, specific sequences within RNA that are critical to function, using modeling of the compound to effect binding to the nucleotide sequences in the RNA in combination with secondary and/or tertiary structure associated with the minor groove of the RNA in the region of the critical sequences. In the preferred method, computer modeling is used along with analysis of the targeted RNA sequence to design molecules binding to the targeted RNA by covalent or hydrogen binding. Appropriate molecules are synthesized using known methodology that have the required structure and chemical characteristics to specifically bind the critical region of the RNA and thereby inhibit the function of the RNA. Molecules known to bind to RNA can also be modified using this method to increase specificity, and thereby decrease toxicity.Type: GrantFiled: May 26, 1994Date of Patent: October 2, 2007Assignee: Massachusetts Institute of TechnologyInventor: Paul R. Schimmel
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Patent number: 7276336Abstract: A method of fabricating an addressable array of biopolymer probes on a substrate according to a target array pattern using a deposition apparatus, and a deposition apparatus which can execute the method and computer program products for the apparatus. The deposition apparatus which, when operated according to a target drive pattern based on nominal operating parameters of the apparatus, provides the probes on the substrate in the target array pattern. The method includes examining at least one operating parameter for an error from a nominal value which error will result in use of the target drive pattern producing a discrepancy between the target array pattern and an actual array pattern deposited. When an error is detected deriving, based on the error, a corrected drive pattern different from the target drive pattern such that use of the corrected drive pattern results in a reduced discrepancy between the target and actual array patterns.Type: GrantFiled: July 22, 1999Date of Patent: October 2, 2007Assignee: Agilent Technologies, Inc.Inventors: Peter G. Webb, Michael P. Caren, Kyle J. Schleifer, Jay K. Bass
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Patent number: 7276337Abstract: The present invention relates to methods for detecting the presence of ribonuclease enzymes, more specifically to methods that provide for a visual detection assay. The methods entail contacting a test sample suspected of containing ribonuclease activity with a substrate containing a ribonuclease-sensitive internucleotide linkage flanked directly or indirectly by a fluorescence reporter group and a dark quencher, such that if a ribonuclease activity is present in the sample, the ribonuclease-sensitive internucleotide linkage is cleaved and the fluorescence reporter group emits a visually detectable signal. The present invention further provides novel nucleic acid compositions used as substrates for such assays and encompasses kits for performing the methods of the invention.Type: GrantFiled: October 27, 2003Date of Patent: October 2, 2007Assignee: Integrated DNA Technologies, Inc.Inventors: Joseph Alan Walder, Mark Aaron Behlke, Eric Jeffrey Devor, Lingyan Huang
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Patent number: 7276338Abstract: Methods of obtaining sequence information about target oligonucleotides by repetitive single molecule hybridization are disclosed. The methods include exposing a target oligonucleotide to one or more copies of a test oligonucleotide; measuring hybridization; dehybridizing the test oligonucleotide; and repeating until the information content from the hybridization trials equals or exceeds the information content of the target oligonucleotide.Type: GrantFiled: November 17, 2004Date of Patent: October 2, 2007Inventor: Joseph M. Jacobson
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Patent number: 7276339Abstract: This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.Type: GrantFiled: November 18, 2004Date of Patent: October 2, 2007Assignee: H. Lundbeck A/SInventors: Christophe P. G. Gerald, Kenneth A. Jones, James A. Bonini, Beth E. Borowsky, Douglas A. Craig
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Patent number: 7276340Abstract: Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) assays, systems, methods and kits for the age determination of an individual from bloodstains or samples of unknown origin. The methodology is based on gene expression profiling analysis in which novel human newborn fetal specific genes are identified by detecting the presence of appropriate messenger RNA species.Type: GrantFiled: September 21, 2005Date of Patent: October 2, 2007Assignee: University of Central Florida Research Foundation, Inc.Inventors: John Ballantyne, Michelle Alvarez
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Patent number: 7276341Abstract: A number of octapeptides were generated from the sequences encoding the 60 kDa Ro/SSA peptide, the La/SSB autoantigen, the 70 kD nuclear ribonucleoprotein (nRNP), and the Sm B/B? polypeptide, which represent linear epitopes for autoantibodies present in the sera of SLE and SS patients. These peptides are useful in solid phase assays for patients characterized by the presence of these autoantibodies, and can be used to categorize patients as to the likelihood of developing certain conditions associated with SLE. The peptides are also potentially useful in treatment of these patients using immobilized peptide to remove autoantibody and to block binding of the autoantibodies with patient molecules reactive with the autoantibodies.Type: GrantFiled: February 27, 2003Date of Patent: October 2, 2007Assignee: Oklahoma Medical Research FoundationInventors: John B. Harley, Judith A. James
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Patent number: 7276342Abstract: The present invention relates to the field of metabolic research, in particular the discovery of compounds effective for reducing body mass and useful for treating obesity-related diseases and disorders. The obesity-related diseases or disorders envisioned to be treated by the methods of the invention include, but are not limited to, hyperlipidemia, atherosclerosis, insulin resistance, diabetes, and hypertension. In particular, the invention provides for methods of identifying and using AGONISTS and ANTAGONISTS of XOBESIN activity, wherein said activity is selected from the group consisting of lipid partitioning, lipid metabolism, and insulin-like activity.Type: GrantFiled: July 31, 2002Date of Patent: October 2, 2007Assignee: Serono Genetics Institute S.A.Inventors: John Lucas, Deno P. Dialynas, Kristen Briggs
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Patent number: 7276343Abstract: The present invention provides a chemiluminescence enhancer treated to retain favorable dispersibility of fine solid carriers and stably exert a chemiluminescence enhancing action. The invention provides a chemiluminescence enhancer used for signal detection in a solid phase immunoassay using antigen or/and antibody immobilized onto fine solid carriers dispersible in a liquid medium, consisting of a water soluble macromolecular quaternary ammonium salt, a quaternary sulfonium salt or a quaternary phosphonium salt in order to enhance emission of light caused by an enzymatic reaction of a chemiluminescent substrate having dioxetane, wherein the chemiluminescence enhancer is given an aggregation inhibition treatment of the fine solid carriers by the treatment with an oxidizing agent or a reducing agent, and a chemiluminescence method and a kit using the chemiluminescence enhancer.Type: GrantFiled: June 24, 2003Date of Patent: October 2, 2007Assignee: Fujirebio Inc.Inventors: Kazushige Moriyama, Tetsuji Tanimoto, Tatsuki Matsuno, Yoshihiro Ashihara
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Patent number: 7276344Abstract: A protein which inhibits osteoclast differentiation and/or maturation and a method of production of the protein. The protein is produced by human embryonic lung fibroblasts and has molecular weight of about 60 kD and about 120 kD under non-reducing conditions and about 60 kD under reducing conditions on SDS-polyacrylamide gel electrophoresis, respectively. The protein can be isolated and purified from culture medium of the said fibroblasts. Furthermore, the protein can be produced by gene engineering. The present invention includes cDNA for producing the protein by gene engineering, antibodies having specific affinity to the protein or a method for determination of the protein concentration using the antibodies.Type: GrantFiled: February 25, 2004Date of Patent: October 2, 2007Assignee: Sankyo Co., Ltd.Inventors: Masaaki Goto, Eisuke Tsuda, Shin'ichi Mochizuki, Kazuki Yano, Fumie Kobayashi, Nobuyuki Shima, Hisataka Yasuda, Nobuaki Nakagawa, Tomonori Morinaga, Masatsugu Ueda, Kanji Higashio
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Patent number: 7276345Abstract: The invention relates to novel human adenylyl cyclase nucleic acid and amino acid sequences. Also provided are vectors, host cells, recombinant methods for making and using the novel molecules and methods for identifying compounds which bind to the adenylyl cyclase proteins.Type: GrantFiled: July 22, 2004Date of Patent: October 2, 2007Assignees: Millennium Pharmaceuticals, Inc., University of WashingtonInventors: Daniel R. Storm, Beth Hacker, James E. Tomlinson
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Patent number: 7276347Abstract: Novel conjugates of protected aldehyde active metabolites of cyclophosphamide including reagents and immunogens thereof and monoclonal antibodies generated by these immunogens, said reagents and immunogens useful in immunoassays for the monitoring of the active metabolites of cyclophosphamide in patients being treated with cyclophosphamide.Type: GrantFiled: July 20, 2005Date of Patent: October 2, 2007Assignee: Saladax Biomedical Inc.Inventors: Salvatore J. Salamone, Jodi Blake Courtney, Dennis Stocker
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Patent number: 7276348Abstract: The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, and hyperproliferation, and the like.Type: GrantFiled: March 8, 2004Date of Patent: October 2, 2007Assignee: Regents of the University of MichiganInventor: Gary D. Glick
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Patent number: 7276349Abstract: Disclosed are various forms of an active, isolated ?-secretase enzyme in purified and recombinant form. This enzyme is implicated in the production of amyloid plaque components which accumulate in the brains of individuals afflicted with Alzheimer's disease. Recombinant cells that produce this enzyme either alone or in combination with some of its natural substrates (?-APPwt and ?-APPsw) are also disclosed, as are antibodies directed to such proteins. These compositions are useful for use in methods of selecting compounds that modulate ?-secretase. Inhibitors of ?-secretase are implicated as therapeutics in the treatment of neurodegenerative diseases, such as Alzheimer's disease.Type: GrantFiled: March 25, 2005Date of Patent: October 2, 2007Assignee: Elan Pharmaceuticals, Inc.Inventors: John P. Anderson, Guriqbal Basi, Minh Tam Doan, Normand Frigon, Varghese John, Michael Power, Sukanto Sinha, Gwen Tatsuno, Jay Tung, Shuwen Wang, Lisa McConlogue
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Patent number: 7276350Abstract: A method for diagnosing the presence in an animal of an infection due to a microorganism in which a test sample obtained from the animal is exposed to a population of the microorganism and the presence of binding of the microorganism by an antibody in the test sample is determined.Type: GrantFiled: April 27, 2004Date of Patent: October 2, 2007Assignee: University of Tennessee Research FoundationInventors: Shigetoshi Eda, Clarence A. Speer
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Patent number: 7276351Abstract: A method of analyzing cells disposed in media within a vessel includes the steps of providing a vessel having an original volume of media about the cells, reducing the original volume of media about at least a portion of the cells to define a reduced volume of media, and analyzing a constituent related to the cells within the reduced volume of media. An apparatus for analyzing cells includes a stage adapted to receive a vessel holding cells and a volume of media, a plunger adapted to receive a barrier to create a reduced volume of media within the vessel including at least a portion of the cells, the barrier adapted for insertion into the vessel by relative movement of the stage and the plunger, and a sensor in sensing communication with the reduced volume of media, wherein the sensor is configured to analyze a constituent disposed within the reduced volume.Type: GrantFiled: October 17, 2003Date of Patent: October 2, 2007Assignee: Seahorse BioscienceInventors: Jay S. Teich, Andy C. Neilson, Michael R. Sweeney, Geoff Uhl
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Patent number: 7276352Abstract: The present invention provides methods for inducing insulin gene expression in cultured pancreas cells, the method comprising contacting a culture of endocrine pancreas cells expressing a PDX-1 gene with a GLP-1 receptor agonist, wherein the cells have been cultured under conditions such that the cells are in contact with other cells in the culture, thereby inducing insulin gene expression in the ceils. The invention also provides methods of treating a diabetic human subject using the methods of the invention.Type: GrantFiled: January 19, 2005Date of Patent: October 2, 2007Assignee: The Regents of the University of CaliforniaInventors: Fred Levine, Dominique Gouty
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Patent number: 7276353Abstract: The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products.Type: GrantFiled: December 9, 2002Date of Patent: October 2, 2007Assignees: Virginia Tech Intellectual Properties, Inc., Iowa State University Research Foundation, Inc.Inventors: Xiang-Jin Meng, Martijn Fenaux, Patrick G. Halbur
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Patent number: 7276354Abstract: The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing these polypeptides. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing these polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY28, HGPRBMY29, HGPRBMY29v1, and HGPRBMY29v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.Type: GrantFiled: March 3, 2005Date of Patent: October 2, 2007Assignee: Bristol-Myers Squibb CompanyInventors: John N. Feder, Chandra S. Ramanathan, Gabriel A. Mintier, David Bol