Patents Issued in May 20, 2008
  • Patent number: 7374897
    Abstract: The present invention provides a method for assaying alpha-methylacyl-CoA racemase activity. In the assay, a sample containing an alpha-methylacyl-CoA racemase or suspected of containing an alpha-methylacyl-CoA racemase is contacted with (2R)-pristanoyl-CoA. If alpha-methylacyl-CoA racemase is present in the sample, (2R)-pristanoyl-CoA is converted into (2S)-pristanoyl-CoA. The method then utilizes a cycling reaction system between (2S)-pristanoyl-CoA and trans-2,3-dehydropristanoyl-CoA to generate a detectable signal that corresponds to the alpha-methylacyl-CoA racemase activity. Kits for assaying alpha-methylacyl-CoA racemase based on the same principle are also provided.
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: May 20, 2008
    Assignee: General Atomics
    Inventor: Chong-Sheng Yuan
  • Patent number: 7374898
    Abstract: The invention generally relates compositions and methods for the treatment of patients with melanoma and other malignant cancers. The compositions of the present invention are novel peptide sequences that inhibit seprase-mediated cell migration. Said sequences may also be used for diagnostics and library screening protocols.
    Type: Grant
    Filed: October 11, 2005
    Date of Patent: May 20, 2008
    Assignee: The Research Foundation of State University of New York
    Inventor: Wen-Tien Chen
  • Patent number: 7374899
    Abstract: The present invention relates to the use of a polypeptide with the biological activity of a sucrose-6-phosphate phosphatase which, if not present, brings about growth retardation symptoms and chlorotic leaves and which is encoded by the nucleic acid sequences SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5 or by a functional equivalent of SEQ ID NO:1, SEQ ID NO:3 or SEQ ID NO:5 as target for herbicides. Moreover, the present invention relates to the use of the abovementioned polypeptides in a method for identifying herbicidal or growth-regulatory compounds which inhibit sucrose-6-phosphate phosphatase. Moreover, the invention relates to the use of these compounds which have been identified via the method as herbicides or growth regulators.
    Type: Grant
    Filed: July 16, 2003
    Date of Patent: May 20, 2008
    Assignee: BASF Aktiengesellschaft
    Inventors: Thomas Ehrhardt, Uwe Sonnewald, Frederik Börnke, Shuai Chen
  • Patent number: 7374900
    Abstract: Disclosed are compounds of the formula (I): wherein R3, R4, R5, R9, and R10 are selected from the group consisting of H and groups or atoms other than H, and R6 and R8 are halo or hydrogen; X1, X2, and X3 are independently O or S; provided that R9 and R10 are not simultaneously H, when all of X1, X2, and X3 are O; and of the formula (II) wherein R11-R14 are selected from the group consisting of H and groups or atoms other than H; X4-X9 are independently O or S; n and m are 0 or 1 but m and n cannot be 0 simultaneously; R15-R24 can be H or any substituent so long as the compound of formula II upon hydrolysis provides a fluorescent compound. These compounds are useful as substrates with high specificity for organophosphatase particularly human paraoxonase and bacterial organophosphorus hydrolase.
    Type: Grant
    Filed: March 16, 2004
    Date of Patent: May 20, 2008
    Assignee: The American National Red Cross
    Inventors: Serguei Soukharev, David Hammond
  • Patent number: 7374901
    Abstract: The present invention relates to an analysis method and analysis system that can accurately analyze the contents of coenzyme Q-10 and a 2-electron reduced form thereof in a specimen, in which human blood plasma as the specimen is mixed with isopropyl alcohol as a pretreatment and the coenzyme Q-10 and the 2-electron reduced form thereof are extracted to the isopropyl alcohol. Extracted liquid is stored at a temperature of 4° C. until the analysis is performed. The extracted liquid as an analytical sample is analyzed by an analysis system provided with a liquid-sending mechanism, a switching mechanism, a concentration column, a separation column, a reduction column, an ultraviolet absorption detector, and an electrochemical detector.
    Type: Grant
    Filed: December 3, 2003
    Date of Patent: May 20, 2008
    Assignee: Shiseido Company Ltd.
    Inventors: Yorihiro Yamamoto, Masashi Mita
  • Patent number: 7374902
    Abstract: The present invention provides a method for assaying alpha-methylacyl-CoA racemase activity. In the assay, a sample containing an alpha-methylacyl-CoA racemase or suspected of containing an alpha-methylacyl-CoA racemase is contacted with (2R)-2-methylacyl-CoA. If alpha-methylacyl-CoA racemase is present in the sample, (2R)-2-methylacyl-CoA is converted into (2S)-2-methylacyl-CoA. The method then utilizes a cycling reaction system between (2S)-2-methylacyl-CoA and trans-2,3-dehydroacyl-CoA to generate a detectable signal that corresponds to the alpha-methylacyl-CoA racemase activity. Kits for assaying alpha-methylacyl-CoA racemase based on the same principle are also provided.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: May 20, 2008
    Assignee: General Atomics
    Inventor: Chong-Sheng Yuan
  • Patent number: 7374903
    Abstract: The present invention relates to novel substrates, to methods of making them and to uses therefor. The substrates of the invention comprise a base portion and a surface layer covering at least part of the base portion, with a binding layer provided therebetween. The surface layer provides, on at least a part of the substrate, topographical features having at least one nano scale dimension. These topographical features are adapted to facilitate, influence, control or inhibit cell or tissue growth thereon and/or therebetween and the substrate may be used for the study, manipulation or modification of at least one cellular or tissue behavior or response.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: May 20, 2008
    Assignee: The University of Liverpool
    Inventors: Brian G. Cousins, Michael Joseph Garvey, John Fink, Rachel Lucinda Williams, Patrick Joseph Doherty
  • Patent number: 7374904
    Abstract: A method for forming a substantially solid product containing a desired quantum of bioparticle, the method comprising (a) providing a sample of bioparticle in liquid form; (b) selecting a desired quantum of the bioparticle; and (c) forming a substantially solid product containing the desired quantum of the bioparticle, wherein the product is capable of being transferred between containers in its solid form without loss of bioparticle, and wherein the product is capable of releasing the bioparticle in a liquid.
    Type: Grant
    Filed: September 4, 2002
    Date of Patent: May 20, 2008
    Assignee: BTF Pty Ltd
    Inventors: Graham Vesey, Mark Gauci
  • Patent number: 7374905
    Abstract: The present invention is directed to a medium, broth or agar, and a method of utilizing the same, in order to isolate and/or identify anaerobes from a mixed sample that contains facultative microorganisms. The medium contains an inhibitor of the electron transport system, such as a salt of azide (N3?), cyanide (CN?) or related compounds. These inhibitors are present in an amount sufficient to limit the growth of facultative microorganisms under anaerobic conditions while not inhibiting the growth of the anaerobe microorganisms. Preferably, the inhibitor is present in the amount of from about 0.1 mg/ml to about 1.0 mg/ml in broth medium, and from about 0.01 mg/ml to 1.0 mg/ml in agar medium.
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: May 20, 2008
    Assignee: Oxyrase, Inc.
    Inventors: James C. Copeland, Kathy J. Myers
  • Patent number: 7374906
    Abstract: The present invention discloses a device for monitoring chemotaxis or chemoinvasion. The present invention further provides a flexible assay system and numerous assays that can be used to test biological interactions and systems. Laminar flow gradients are employed that mimic gradient situations present in vivo.
    Type: Grant
    Filed: October 21, 2003
    Date of Patent: May 20, 2008
    Assignee: Surface Logix, Inc.
    Inventors: Gregory L. Kirk, Emanuele Ostuni, Enoch Kim, Olivier Schueller, Paul Sweetnam
  • Patent number: 7374907
    Abstract: An apparatus and method for producing tissue slides is disclosed. The apparatus includes a holding assembly for manipulating the sample block, a blade assembly for preparing a thin section from the sample block, and a transfer roller mechanism for transferring the thin section to a receiving medium. The apparatus further includes a controller that may track the sample block and thin section. The method includes the steps of first locating a sample embedded within a support medium, which may be paraffin or a similar medium. Next, the embedded sample is oriented in such a way that its working surface is presented. This orientation may entail determining the orientation of the embedded sample with respect to the blade that will produce the largest cross-sectional area. Next, a slice of the sample from said embedded sample is removed and subsequently transferred to a suitable receiving medium, which may include a microscope slide.
    Type: Grant
    Filed: April 7, 2000
    Date of Patent: May 20, 2008
    Inventors: John Voneiff, Jay Gibson, Gary Pasternack
  • Patent number: 7374908
    Abstract: It is intended to provide a process for conveniently and efficiently producing large amounts of astaxanthin and canthaxanthin from a material which can be easily obtained. A microorganism Thraustochytrium sp. CHN-3 (FERM P-18556) capable of producing astaxanthin and canthaxanthin, which belongs to the genus Labyrinthula and the Thraustochytrium species, is cultured and thus astaxanthin and canthaxanthin are accumulated in the microbial cells. Then the cells are separated from the medium and astaxanthin and canthaxanthin are collected from the separated cells by extracting with a solvent.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: May 20, 2008
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventor: Yukiho Yamaoka
  • Patent number: 7374909
    Abstract: A B1 protein, its isoforms, analogs, fragments and derivatives, DNA encoding it and recombinant production are provided. The protein is useful in the modulation of intracellular inflammation, cell death and/or cell survival pathways.
    Type: Grant
    Filed: June 1, 1998
    Date of Patent: May 20, 2008
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Wallach, Mark Boldiin, Nikolai Malinin
  • Patent number: 7374910
    Abstract: The present invention relates to a peptide comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 35 and having an ability of binding to a receptor protein comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, or a precursor thereof, its amide or ester, or a salt thereof. An inventive peptide-encoding DNA or equivalent can be employed in (1) a development of a receptor binding assay system using an expression system of a recombinant receptor protein and a screening for a pharmaceutical candidate compound, and (2) a development of a pharmaceutical having a reduced side effect such as a memory function improving agent, an appetite improving agent, an uterine, renal, prostatic, testicular or skeletal muscle function regulating agent.
    Type: Grant
    Filed: March 15, 2006
    Date of Patent: May 20, 2008
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Tetsuya Ohtaki, Hideki Matsui, Yoshihiro Ishibashi, Kazuhiro Ogi, Chieko Kitada
  • Patent number: 7374911
    Abstract: Disclosed in an interleukin-1 related gene and gene product. In particular, the invention relates to a protein that is highly homologous to known interleukin-1 cytokines, nucleic acid molecules that encode such a protein, antibodies that recognize the protein, and methods for diagnosing conditions related to host inflammatory and immune responses.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: May 20, 2008
    Inventors: Mark A. Labow, Vadim Iourgenko
  • Patent number: 7374912
    Abstract: Chimeric proteins constructed from the fusion of the naturally occurring form of the soluble IL-6 receptor and IL-6 which are useful for treatment of cancer and liver disorders, enhancement of bone marrow transplantation, and treatment of other IL-6 related conditions are provided.
    Type: Grant
    Filed: March 20, 2007
    Date of Patent: May 20, 2008
    Assignee: Yeda Research and Development Co., Ltd.
    Inventors: Michel Revel, Judith Chebath, Tsvee Lapidot, Orit Kollet
  • Patent number: 7374913
    Abstract: The present invention realized isothermal and rapid polynucleotide synthesis by using as templates polynucleotides having a structure capable of forming loops, and combining a plurality of primers capable of providing a starting point for complementary strand synthesis to such loops. If the LAMP method is applied, all reactions can be carried out isothermally and rapidly since the template polynucleotides themselves can also be synthesized by an isothermal reaction.
    Type: Grant
    Filed: September 19, 2001
    Date of Patent: May 20, 2008
    Assignee: Eiken Kagaku Kabushiki Kaisha
    Inventor: Kentaro Nagamine
  • Patent number: 7374914
    Abstract: We have now discovered that mammals have a DNA gene analogous to that existing in bacteria. MSH5 defects or alterations in this mismatch repair pathway in a mammal, such as a human, can be diagnostic of a predisposition to cancer, and prognostic for a particular cancer: We have discovered and sequenced MSH5 in a number of mammals, including humans. This gene can be used in assays, to express gene product, for drug screens, and therapeutically.
    Type: Grant
    Filed: October 7, 2003
    Date of Patent: May 20, 2008
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Richard Kolodner, Nena Winand
  • Patent number: 7374915
    Abstract: A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.
    Type: Grant
    Filed: August 6, 2002
    Date of Patent: May 20, 2008
    Assignee: Meiji Dairies Corporation
    Inventors: Yoshio Sato, Seiya Makino, Nobuo Yoda, Kakuhei Isawa, Tomonori Kamiyama, Kenichi Hojo, Mizue Saito, Naoki Taketomo, Keisuke Furuichi, Shuji Ikegami
  • Patent number: 7374916
    Abstract: Methods and devices for the regulation of aggrecan gene expression in cartilage cells via the application of fields generated by specific and selective electric and electromagnetic signals in the treatment of diseased or injured articular cartilage. By gene expression is meant the up regulation or down regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased cartilage tissue that include generating specific and selective electric and electromagnetic signals that generate fields optimized for aggrecan gene expression and exposing cartilage tissue to the fields generated by specific and selective signals so as to regulate aggrecan gene expression in such cartilage tissue. The resulting methods and devices are useful for the targeted treatment of osteoarthritis, rheumatoid arthritis, cartilage injury, and cartilage defects.
    Type: Grant
    Filed: September 26, 2002
    Date of Patent: May 20, 2008
    Assignee: The Trustees Of The University of Pennsylvania
    Inventor: Carl T. Brighton
  • Patent number: 7374917
    Abstract: Described herein are novel nucleic acids, proteins and methods that can be used to provide new catalysts with desirable traits for industrial processes. In particular, novel reductases isolated from the environment using PCR methods are described.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: May 20, 2008
    Assignee: Genencor International, Inc.
    Inventors: Mark Donnelly, William H. Eschenfeldt, Jonathan Trent
  • Patent number: 7374918
    Abstract: An isolated DNA molecule encoding modified sarcosine oxidases having optimal pH, high activity in the slightly acidic range and improved stability and a method for preparing the modified sarcosine oxidases is disclosed.
    Type: Grant
    Filed: January 26, 2007
    Date of Patent: May 20, 2008
    Assignee: Kikkoman Corporation
    Inventors: Keisuke Furukawa, Naoki Kajiyama
  • Patent number: 7374919
    Abstract: A novel gene defining a novel enzyme in the UDP-D-galactose: b-N-acetyl-glucosamine ?-1,4-galactosyltransferase family, termed ?4Gal-T2, with unique enzymatic properties is disclosed. The enzymatic activity of ?4Gal-T2 is shown to be distinct from that of previously identified enzymes of this gene family. The invention discloses isolated DNA molecules and DNA constructs encoding ?4Gal-T2 and derivatives thereof by way of amino acid deletion, substitution or insertion exhibiting ?4Gal-T2 activity, as well as cloning and expression vectors including such DNA, cells transfected with the vectors, and recombinant methods for providing ?4Gal-T2. The enzyme ?4Gal-T2 and ?4Gal-T2-active derivatives thereof are disclosed, in particular soluble derivatives comprising the catalytically active domain of ?4Gal-T2.
    Type: Grant
    Filed: April 13, 2005
    Date of Patent: May 20, 2008
    Assignee: GlycoZym ApS
    Inventors: Henrik Clausen, Eric Paul Bennett
  • Patent number: 7374920
    Abstract: The present invention is directed to nucleic acid sequences of Ginkgo biloba diterpene synthases, particularly of a levopimaradiene synthase. More specifically, the invention is directed to a cell of a unicellular organism, such as Saccharomyces cerevisiae or Escherichia coli, comprising levopimaradiene synthase for the metabolically engineered in vivo biosynthesis of a diterpene and a ginkgolide.
    Type: Grant
    Filed: June 24, 2005
    Date of Patent: May 20, 2008
    Assignee: William Marsh Rice University
    Inventors: Seiichi P. T. Matsuda, Hala G. Schepmann
  • Patent number: 7374921
    Abstract: Disclosed is a novel cellulase having an amino acid sequence in which the 162nd and/or 166th amino acid residues in the amino acid sequence of cellulase NCE5 are substituted. Further, a polynucleotide encoding the novel cellulase, an expression vector containing the polynucleotide, a host cell transformed with the expression vector, and a cellulase preparation and a washing composition containing the cellulase are disclosed. The cellulase of the present invention is resistant to surfactants, and maintains a high activity even under alkaline conditions.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: May 20, 2008
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Kaoru Okakura, Koji Yanai
  • Patent number: 7374922
    Abstract: The invention relates to a genetically engineered variant of a parent starch debranching enzyme, i.e. a pullulanase or an isamylase, the enzyme variant having an improved thermostability at a pH in the range of 4-6 compared to the parent enzyme and/or an increased activity towards amylopectin and/or glycogen compared to the parent enzyme, to methods for producing such starch debranching enzyme variants with improved thermostability and/or altered substrate specificity, and to a method for converting starch to one or more sugars using at least one such enzyme variant.
    Type: Grant
    Filed: February 26, 2003
    Date of Patent: May 20, 2008
    Assignee: Novozymes A/S
    Inventors: Henrik Bisgard-Frantzen, Allan Svendsen
  • Patent number: 7374923
    Abstract: A screening tool and a screening method for a therapeutic agent for type II diabetes, particularly an agent for alleviating insulin resistance are disclosed. A novel polypeptide, a polynucleotide, a vector, a promoter, and a transformant which are useful in the screening tool and the screening method, are also disclosed.
    Type: Grant
    Filed: November 7, 2006
    Date of Patent: May 20, 2008
    Assignee: Astellas Pharma Inc.
    Inventors: Kunitake Abe, Masayoshi Takeda, Noboru Yamaji, Miyuki Katou, Tetsuo Matsui
  • Patent number: 7374924
    Abstract: The invention herein provides certain strains of lactic acid bacteria selected for their capability of promoting production of IL-10 and consequently proliferation of CD4+CD25+ TR cells, for prophylaxis and/or treatment of infant colic, a method of selecting such strains, and products containing such strains.
    Type: Grant
    Filed: June 5, 2006
    Date of Patent: May 20, 2008
    Assignee: Biogaia AB
    Inventors: Eamonn Connolly, Bo Mollstam
  • Patent number: 7374925
    Abstract: The present invention relates to novel micro-organism, Penicillium funiculosum, to new enzymes mixture obtained from it and nucleic acid sequences thereto.
    Type: Grant
    Filed: November 19, 2002
    Date of Patent: May 20, 2008
    Assignee: Adisseo France SAS
    Inventors: Alain Sabatier, Neville Marshall Fish, Nigel Paterson Haigh
  • Patent number: 7374926
    Abstract: The present invention particularly relates to a chemoenzymatic process for the stereoselective preparation of both enantiomers of 3-hydroxy-4-trityloxy butanenitrile key intermediates for the preparation of (R)-GABOB by lipase mediated kinetic resolution of its racemates and their effective application in the enantioconvergent synthesis of (R)-GABOB.
    Type: Grant
    Filed: December 23, 2004
    Date of Patent: May 20, 2008
    Assignee: Council of Scientific and Industrial Research
    Inventors: Ahmed Kamal, Gollapalli B. Ramesh Khanna, Krishnaji Tadiparthi, Ramu Rondla
  • Patent number: 7374927
    Abstract: The invention provides arrays for analysis of compromised nucleic acid samples, for example, nucleic acids obtained from formalin fixed paraffin embedded samples and methods to analyzed these compromised samples. Arrays are disclosed in which the probe selection region used to select probes for the array is the 300 bases of the target MRNA that are immediately upstream of the start of the poly(A) tail of the mRNA. The probes selected for the array are more biased toward the 3? end of the mRNA than other arrays that are currently available.
    Type: Grant
    Filed: May 3, 2005
    Date of Patent: May 20, 2008
    Assignee: Affymetrix, Inc.
    Inventors: John F. Palma, Eric B. Schell, Alan J. Williams
  • Patent number: 7374928
    Abstract: The invention relates to a bioreactor for cultivating microorganisms, as well as a method for its production. The invention is characterized in that the bioreactor (1) comprises two identically constructed base elements (2,3) that are constructed in trough shape and consist of a bottom part (4) and four side parts (5) arranged on a bottom part (4) and having an inside depth T1. The base element (2,3) consists of a light permeable material. The identically constructed base elements (2,3) are arranged on each other so as to exactly cover each other. A flow guide device is arranged inside the identically constructed base elements (2,3).
    Type: Grant
    Filed: September 24, 2001
    Date of Patent: May 20, 2008
    Assignee: Fraunhofer-Gesellschaft zur Forderung der angewandten Forschung e.V
    Inventor: Walter Trösch
  • Patent number: 7374929
    Abstract: This concerns a device whose filtering membrane (4) is gripped annularly at the periphery between an annular transverse wall (32) forming part of a drainage body and an axially oriented cylindrical wall (9) of an intake body, which lateral wall has an elastomer seal (13) which forms the edge thereof and by means of which this wall comes into contact with the membrane (4), this device being provided with a second seal (55) which has an arched profile, the external annular end (61) of which bears against said annular transverse wall (32) radially beyond said membrane (4), and the internal end (57) of which is connected to said seal (13) on the lateral wall (9) of said reservoir (5), hereinafter referred to as the first seal.
    Type: Grant
    Filed: October 9, 2002
    Date of Patent: May 20, 2008
    Assignee: Millipore Corporation
    Inventors: Christian Schann, Gérard Muller, Frédéric Reynes, Christian Clauss
  • Patent number: 7374930
    Abstract: This patent discloses compositions and methods of use thereof to normalize the blood glucose levels of patients with type 2 diabetes. It relates particularly to a plasmid comprising a chicken ? actin promoter and enhancer; a modified GLP-1 (7-37) cDNA (p?GLP1), carrying a furin cleavage site, which is constructed and delivered into a cell for the expression of active GLP-1.
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: May 20, 2008
    Assignee: Expression Genetics, Inc.
    Inventors: Seungjoon Oh, Minhyung Lee, Kyungsoo Ko
  • Patent number: 7374931
    Abstract: Using nucleic acids encoding mutant SEA and SEB exotoxins from Staphylococcus aureus, compositions and methods for use in inducing an immune response which is protective against staphylococcal aureus intoxication in subjects is described.
    Type: Grant
    Filed: April 2, 2003
    Date of Patent: May 20, 2008
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: John S. Lee, Peter Pushko, Jonathan F. Smith, Robert G. Ulrich
  • Patent number: 7374932
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: December 29, 2004
    Date of Patent: May 20, 2008
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: D. Wade Walke, Erin Hilbun, Gregory Donoho, C. Alexander Turner, Jr., Gwenn Hansen, Hector BeltrandelRio, Isaac Van Sligtenhorst
  • Patent number: 7374933
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in thereapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: May 20, 2008
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: D. Wade Walke, Nathaniel L. Wilganowski, C. Alexander Turner, Jr.
  • Patent number: 7374934
    Abstract: The present invention relates to novel immortalized precursor cell populations derived from embryonic stem cell populations and methods to produce such cell populations. Also disclosed is an assay to identify regulatory compounds capable of controlling cell growth for therapeutic and experimental use.
    Type: Grant
    Filed: August 13, 2002
    Date of Patent: May 20, 2008
    Assignee: National Jewish Medical and Research Center
    Inventors: Gordon M. Keller, Robert G. Hawley, Kyunghee Choi
  • Patent number: 7374935
    Abstract: Naturally-occurring variants of human Rgr oncogene protein, in particular, abnormally truncated variants found in T cell malignancies, as well as the human Rgr protein are encompassed by the present invention. Also included are antibodies thereto and nucleic acid molecules encoding human Rgr protein and naturally-occurring variants thereof. The present invention further provides methods for diagnosing and treating T cell malignancies associated with abnormally truncated transcripts of human rgr oncogene and/or abnormal truncation of human Rgr protein.
    Type: Grant
    Filed: July 23, 2003
    Date of Patent: May 20, 2008
    Assignee: New York University
    Inventors: Angel Pellicer, Peter Leonardi, Giorgio Inghirami
  • Patent number: 7374936
    Abstract: The present invention relates to the field of site directed therapy. More specifically the invention relates to site directed radio therapy, and provides a method for production of radioconjugates and an apparatus for radioimmunotherapy. The method, conjugates and apparatus can be practicalized without the need for radioactive shielding and/or airtight facilities. Without these restrictions the invention provides a simple and efficient means of therapy at the bed-side of the patient.
    Type: Grant
    Filed: December 17, 2001
    Date of Patent: May 20, 2008
    Assignee: Actinium Pharmaceuticals, Inc.
    Inventor: Maurits W Geerlings
  • Patent number: 7374937
    Abstract: The invention includes in vitro methods of inducing and enhancing proliferation of human marrow stromal cells for use in, for example, gene therapy and transplantation methods. The invention also includes a method of assessing the expandability (i.e., proliferative capacity) of human marrow stromal cells. In addition, the invention includes a conditioned medium for enhancing proliferation of human marrow stromal cells.
    Type: Grant
    Filed: October 25, 2000
    Date of Patent: May 20, 2008
    Assignee: Philadelphia Health and Education Corporation
    Inventors: Darwin J. Prockop, David Colter, Carla DiGirolamo
  • Patent number: 7374938
    Abstract: A method for producing non-cellulosic callose fiber by using plant protoplast, which imposes less burden to the environment with reduced energy consumption compared to conventional natural fibers is provided; it comprises the addition of an inorganic ion to a plant protoplast cultivation system, which leads the plant protoplast to produce non-cellulosic callose fiber.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: May 20, 2008
    Assignees: Japan Science and Technology Corporation, National Institute of Agrobiological Sciences, Forestry and Forest Products Research Institute
    Inventors: Tetsuo Kondou, Jun Magoshi, Hisashi Abe, Hamako Sasamoto
  • Patent number: 7374939
    Abstract: The present invention briefly provides a method of site-specific insertion in Zymomonas, comprising, providing a Zymomonas gene fragment, interrupting a DNA sequence the fragment, and transforming the Zymomonas through homologous recombination with the interrupted fragment.
    Type: Grant
    Filed: May 1, 2000
    Date of Patent: May 20, 2008
    Assignee: Midwest Research Institute
    Inventors: Min Zhang, Yat-Chen Chou
  • Patent number: 7374940
    Abstract: A substance in a condensed state, for example a powdered solid, is in continuous movement in the longitudinal direction (6) of a furnace (4, 5). A reactive gas mixture is brought into contact with the substance in the condensed state. A plurality of samples of the gaseous mixture are removed at a plurality of reference points (14) spaced apart from one another along the longitudinal direction (6) of the furnace (4, 5); each of the gas samples is analyzed outside the furnace to determine the composition of the gas mixture and for each point (14), the extent of a chemical reaction between the condensed substance and the reactive gas mixture is deduced from the composition of the gas mixture at each of the reference points (14). In particular, the apparatus comprises a sampling and injection rod (10) introduced into the furnace (4, 5) and disposed in its longitudinal direction (6).
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: May 20, 2008
    Assignee: Societe Franco-Belge de Fabrication de Combustible-FBFC
    Inventor: André Feugier
  • Patent number: 7374941
    Abstract: A method and apparatus for determining changes in a supply system, designed to supply repeated pulses of a vapor phase reactant to a reaction chamber is disclosed. One embodiment involves providing the reactant source, and a gas conduit to connect the reactant source to the reaction chamber, a valve positioned in communication with the reactant source such that switching of the valve induces vapor phase reactant pulses from the reactant source to the reaction chamber and a sensor positioned in communication with the reactant source and configured to provide a signal indicative of a characteristic parameter of the reactant pulse as a function of time. A curve is derived from the signal and the shape of the curve is monitored to determine changes in the curve shape over time during subsequent pulses.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: May 20, 2008
    Assignee: ASM Iternational N.V.
    Inventors: Niklas Bondestam, Menso Hendriks
  • Patent number: 7374942
    Abstract: A process and apparatus for testing material libraries, in particular catalysts, by means of coupled use of at least two analytical methods, preferably IR thermography and mass spectrometry. Owing to the selected arrangement, the disadvantages of the two previously known individual methods are compensated for: the subsequent selectivity determination for selected sections by means of mass spectrometry invalidates the argument against IR thermography, of only being able to determine activities; the rapid integrated determination of potentially “good” materials via IR thermography prevents an excessive loss of time by needing to test all materials of a library successively with the mass spectrometer.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: May 20, 2008
    Assignee: BASF Aktiengesellschaft
    Inventors: Jens Klein, Wolfram Stichert, Wolfgang Strehlau, Armin Brenner, Stephan Andreas Schunk, Dirk Demuth
  • Patent number: 7374943
    Abstract: The invention provides a kit for a glycated haemoglobin assay, said kit comprising: a porous membrane capable of retaining precipitated haemoglobin; a first reagent comprising zinc ions in aqueous basic solution or comprising a water soluble zinc compound; a second reagent comprising a chromophore-boronic acid conjugate; and optionally, an aqueous washing reagent; wherein at least one of the first and second reagents further comprises a surfactant capable of lysing erythrocytes, and wherein said second reagent if liquid is acidic.
    Type: Grant
    Filed: April 10, 2002
    Date of Patent: May 20, 2008
    Assignee: Axis-Shield USA
    Inventors: Jostein Holtlund, Kerstin Bernström, Ellen Dworsky, Lise Corneliussen
  • Patent number: 7374944
    Abstract: Bioanalytical device that includes a biofunctional component and an optional sensor component. The device includes arrays of addressable, durable, asymmetric biofunctional membranes containing protein transducers capable of unidirectional transport of analytes. Suitable protein transducers include members of the ATP-binding cassette family, such as P-glycoprotein.
    Type: Grant
    Filed: October 3, 2002
    Date of Patent: May 20, 2008
    Assignee: Purdue Research Foundation
    Inventors: David H. Thompson, Christine A. Hrycyna, Gil U. Lee, Osman A. Basaran, Kinam Park, Igal Szleifer
  • Patent number: 7374945
    Abstract: The present invention features a method and associated kit for increasing the association rate between polynucleotides having complementary, single-stranded regions, where the method includes providing to a test sample containing the complementary polynucleotides one or more synthetic, water soluble polycationic polymers.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: May 20, 2008
    Assignee: Gen-Probe Incorporated
    Inventor: Michael M. Becker
  • Patent number: 7374946
    Abstract: Process and a test kit for the detection of drugs of methylenedioxy amphetamine family and derivatives, are disclosed. The process comprises (a) sampling sufficient amount of a material, suspected to be examined comprise of said methylenedioxyphenyl group; (b) admixing said sample with a sufficient amount of a strong acid reagent; and (c) detecting color gradual appearance and determining accordingly the presence of said methylenedioxy amphetamine drugs in predetermined interval of time. The test kit comprises a strong acid reagent; a color vs time chart comprising means for the detection of a specific drug by means of color and time of appearance, a reaction chamber wherein suspected material and said strong acid reagent are admixed and color is indicated; a sampler having means to collect sufficient amount of suspected material to be tested and to insert it to the reaction chamber.
    Type: Grant
    Filed: December 19, 2002
    Date of Patent: May 20, 2008
    Assignee: Baruch Glattstein
    Inventor: Baruch Glattstein