Abstract: The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK), such as type 2 diabetes. The invention also relates to a novel group of compounds of Formula (I) and to methods for preparing compounds of Formula (I).

Abstract: The present invention relates to processes of producing glutamic acid compounds, for example, monatin, which are useful as, for example, production intermediates for sweetener or pharmaceutical products.

Abstract: The invention provides compounds of formula (I): wherein E, A, B?, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful for treating cancer.

Abstract: The invention relates to a process for preparing phthalic anhydride, in which the catalytic gas-phase oxidation of o-xylene and/or naphthalene is carried out over at least three zones of catalysts of increasing activity, with only the last zone of the catalyst system containing phosphorus and the last zone also comprising at least 10% by weight of vanadium (calculated as V2O5) based on the active composition of the catalyst and having a ratio of vanadium (calculated as V2O5) to phosphorus of greater than 35.

Abstract: This invention provides a novel class of compounds and compositions and synthetic methods related to lactone antioxidant 3-arylbenzofuranones. The compounds may be useful to prevent yellowing and deterioration of organic materials preferably polymers, such as polyurethane foams as one example. The lactone antioxidants may be polymeric, and may also be liquid or paste in physical form at room temperature. Although it is not necessary for its stabilizing properties, the compositions may, in some species, bear one or more reactive primary OH groups on the polymer chains. The chains may also contain oligomeric oxyalkylene ether and aliphatic ester functional groups, in one embodiment of the invention.

Abstract: In the following, citalopram diol means 4-(4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)-benzonitrile, as free base and/or acid addition salt. The invention relates to a process for the preparation of racemic citalopram diol and/or R- or S-citalopram diol, comprising the separation of a non-racemic mixture of R- and S-citalopram diol with more than 50% of one of the enantiomers into a fraction being enriched with S- or R-citalopram diol and a fraction comprising RS-citalopram diol wherein the ratio of R-citalopram diol:S-citalopram diol is equal to 1:1 or closer to 1:1 than in the initial mixture.

Abstract: A method for concentrating trans-xanthophyll esters from marigold oleoresin, which includes blending the oleoresin with a solvent and a co-solvent of lower alkanols and recovering a precipitate enriched with trans-xanthophyll esters at a temperature of above 22° C. The recovery of the trans-xanthophyll esters is greater when using the alkanol blend than when using only a lower alkanol from the said blend. The said process is most useful using a lower-grade, commercially available oleoresin, thereby helping small producers, who do not have access to higher-grade oleoresin made through backward integration to marigold cultivation and harvest.

Abstract: An anti-cancer agent contains a phosphine transition metal complex having a ferrocene skeleton, the complex being represented by general formula (3) below: (wherein R1, R2, R3, and R4 each represent a linear or branched alkyl group, a cycloalkyl group, an alkoxy group, an aryl group, or an aralkyl group; A represents a linear or branched alkyl group, a phenyl group, or a hydrogen atom; M1 represents a transition metal atom selected from the group consisting of gold, copper, platinum, and silver; and X1 represents an anion).

Abstract: Cosmetic compositions for topical use for protecting the skin and the hair, containing, in a cosmetically acceptable support, at least one compound of formula (1) or (2) in which X1 represents R3—(C?O)—, R3—SO2— or R3—O—(C?O)—, X2 represents —(C?O)—R?3—(C?O)—, —SO2—R?3—SO2— or —(C?O)—O—R?3—O—(C?O)—, Y represents —(C?O)—R4 or —SO2R5, R2 represents a C1-8 alkyl group, n is 0, 1 or 2, R3 represents C1-30 alkyl or C3-30 alkenyl, R?3 represents a single bond or a divalent C1-30 alkylene or C3-30 alkenylene radical, R4 represents —OR6 or —NHR6, R5 represents C1-30 alkyl or a phenyl nucleus, R6 represents C1-30 alkyl or C3-30 alkenyl, and novel compounds of formula (2).

Abstract: A method of producing a mixture of fluorine-containing (meth)acrylate esters, the method including: (A) a telomerization step of obtaining the mixture of the fluoroalkyl iodide telomers; (B) an ethylene addition step of adding ethylene to the mixture of the fluoroalkyl iodide telomers obtained in the step (A) to give a mixture of ethylene adducts; and (C) an esterification step of reacting the mixture of the ethylene adducts obtained in the step (B) with a (meth)acrylate compound to obtain fluorine-containing (meth)acrylate esters.

Abstract: An integrated process for the production of an alkenyl carboxylate, such as vinyl acetate which process comprises the steps of (a) contacting in an oxidation reaction zone a C2 to C4 alkane, such as ethane, a molecular oxygen-containing gas, optionally the corresponding alkene and optionally water, in the presence of a catalyst to produce a stream comprising alkene, carboxylic acid and water; (b) separating at least a portion of the stream from step (a) into a fraction comprising the alkene and a fraction comprising the carboxylic acid and water; (c) contacting in a second reaction zone at least a portion of said alkene fraction produced in step (b), a carboxylic acid and a molecular oxygen-containing gas, in the presence of a catalyst to produce a product stream comprising an alkenyl carboxylate, water and carboxylic acid; (d) separating at least a portion of the product stream from step (c) and at least a portion of the carboxylic acid and water fraction produced in step (b) by azeotropic distillation into

Abstract: Disclosed is a method for removing aldehyde impurities from a methyl acetate supply. The method comprises reacting the methyl acetate supply with a polyol and converting the aldehyde impurities to cyclic acetals. The acetals are subsequently removed from the methyl acetate supply by, e.g., distillation. The purified methyl acetate supply is used for carbonylation to produce acetic acid.

Abstract: This invention relates to the field of heterogeneous catalysis, and more particularly to catalysts including carbon supports having formed thereon compositions which comprise a transition metal in combination with nitrogen and/or carbon. The invention further relates to the fields of catalytic oxidation, including the preparation of secondary amines by the catalytic oxidation of tertiary amines.

Abstract: Disclosed is an optimized process and apparatus for more efficiently and economically carrying out the liquid-phase oxidation of an oxidizable compound. Such liquid-phase oxidation is carried out in a bubble column reactor that provides for a highly efficient reaction at relatively low temperatures. When the oxidized compound is para-xylene and the product from the oxidation reaction is crude terephthalic acid (CTA), such CTA product can be purified and separated by more economical techniques than could be employed if the CTA were formed by a conventional high-temperature oxidation process.

Abstract: The present invention relates to pharmaceutical compositions of gabapentin tannate, processes for production of those compositions and methods of use of those compositions. The present invention provides a novel process for preparation of the tannate salt of gabapentin in liquid or semi-solid dosage form for human and veterinary pharmaceutical use. Tannate salts of active pharmaceutical ingredients are used in sustained release applications and to improve certain organoleptic properties such as taste. The process may utilize either natural or synthetic tannic acid.

Abstract: Compounds of formula (I) wherein R1 to R4, X and A are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess utility as tissue-selective androgen receptor modulators (SARM) and are useful in hormonal therapy, e.g., in the treatment or prevention of male hypogonadism and age-related conditions such as andropause.

Abstract: The invention relates to terphenyl derivatives of formula: and to their preparation and to the pharmaceutical compositions comprising them. These compounds exhibit an antagonist activity with respect to CB1 cannabinoid receptors.

Abstract: There is provided a series of substituted oxime-containing acyl guanidines of Formula (I) or a stereoisomer; or a nontoxic pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, and R7 are as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by ?-secretase and, more specifically, inhibit the production of A?-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to ?-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.

Abstract: The invention provides the diastereoselective alkylation of optically active nopinone to form the compound of formula (I) according to scheme A below: in which: —R is a C5-15 alkyl group; —R1 is especially a C1-15 alkyl, C2-15 alkenyl or C2-15 alkynyl group or a C5-15 aryl, each group optionally being substituted; and —X is a halogen atom; and the configuration of the compound of formula (I) is either (E) or (Z) or a mixture of the two. The compound of formula (I) is a valuable synthetic intermediate.

Abstract: A process for preparing a 3-aminophenylacetylene compound of formula (5), including: a) reacting a 3-haloaniline compound of formula (1) with an acetylene compound of formula (2) in the presence of a palladium compound, a copper compound, and an amine compound of formula (3) to form an aniline compound of formula (4); b) precipitating the aniline compound of formula (4) in the form of a crystal, and isolating it by solid/liquid separation; and c) reacting the aniline compound of formula (4) with a base to obtain 3-aminophenylacetylene.

Abstract: A process for alkylation of a N?-phenyl-N-alkyl-p-phenylenediamine of specified formula in an ionic liquid unexpectedly produces a N?-phenyl-N-alkyl(alkylphenylene)diamine of a second specified formula. The use of an inorganic liquid permits convenient separation of the alkylated reaction product from the reaction mixture.

Abstract: The invention relates to a method for the continuous synthesis of monoalkyl-hydrazines with a functionalized alkyl group. The inventive method is characterized in that it comprises a step consisting in demixing a solution containing the synthesized monoalkyl-hydrazine, by reacting an anhydrous amine with monochloramine, in an organic phase and an aqueous phase with the addition of anhydrous sodium hydroxide. The invention can be used to obtain perfect selectivity in relation to monoalkyl-hydrazine without the presence of the di- and tri-substituted forms thereof. According to the invention, the staffing amine which has not reacted is collected and reused directly without any additional treatment.

Abstract: The invention relates to a process for ketalizing triacetonamine by reacting triacetonamine and a hydroxyl derivative, for example, a mono- or polyhydric alcohol, with gaseous hydrogen chloride to give an open-chain or cyclic ketal.

Abstract: Materials and methods for preparing P-chirogenic monophospholanes and bisphospholanes are disclosed. The methods employ stereoselective cyclization to generate the phospholane rings followed by pyramidal inversion to access a variety of P-chirogenic phospholanes. When bound to transition metals such as rhodium, the disclosed P-chirogenic phospholanes may be used as catalysts in asymmetric synthesis of valuable pharmaceutical chemical entities, including pregabalin.

Abstract: Process for preparing high-concentration gaseous formaldehyde having a molar CH2O:H2O ratio of ?0.6 from an aqueous formaldehyde solution by evaporation of at least part of the solution, in which the aqueous formaldehyde solution is heated to a vaporization temperature T and the gas phase formed is taken off, wherein the evaporation temperature T obeys the relationship: T[° C.]?T?min[° C.] where T?min(c)=A+B×(c/100)+C×(c/100)2+D×(c/100)3 and A=+68.759, B=+124.77, C=?12.851, D=?10.095, where c is the instantaneous CH2O content of the aqueous formaldehyde solution during the evaporation in percent by weight and is from 20 to 99% by weight.

Abstract: In a process for reducing the Bromine Index of a feed containing a linear alkylbenzene and bromine-reactive olefinic hydrocarbon contaminants, the feed is contacted under conditions effective to remove bromine-reactive olefinic hydrocarbon contaminants with a catalyst comprising zeolite Y catalyst having an alpha value of about 2 to about 30. The feed will normally also contain benzene and linear paraffin remaining from the alkylation process used to produce the linear alkylbenzene.

Abstract: A method and apparatus for removing uranium (IV) and uranium (VI) from sands and soils. The method and device assays a volume of soil and determines a presence and position of uranium enrichment. A concentration of uranium enrichment is determined, and compared to a threshold concentration. The volume of soil is processed and transported to a coarse screen, deck screen and classified in a classifier. In the classifier, the volume of soil is separated into a washed and fines fraction, assayed and transported to a uranium recovery facility, then transported to a silicon removal process and subsequent ammonia and metals removal processes.

Abstract: The present invention includes a patch. The patch includes a main body with a base portion and a vapor emitting portion. The base portion includes a hydrogel comprising a first surface and an opposing surface. The vapor emitting portion is attached to the first surface of the hydrogel. A vapor emitting material is incorporated in the vapor emitting portion.

Abstract: A method for the commercial production of chymosin which involves the recombinant expression of chymosin in plant seeds, that enables chymosin to accumulate to at least 0.5% (w/w) of total seed protein is described. An improved method for the isolation of chymosin from the seed is also described.

Abstract: The present invention relates to non-naturally occurring plants that display enhanced agronomic characteristics due to elevated levels of nitrogen utilization proteins in the root of the plants. In particular, the present invention relates to non-naturally occurring plants with elevated levels of nitrogen utilization proteins specifically localized to the root epidermis of the plant. In addition, the present invention includes a preferred method of generating such non-naturally occurring plants by introducing into the plant a transgene encoding a nitrogen utilization protein operably linked to a root-epidermis-specific promoter.

Abstract: The invention relates to the soybean variety designated 4735486. Provided by the invention are the seeds, plants and derivatives of the soybean variety 4735486. Also provided by the invention are tissue cultures of the soybean variety 4735486 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety 4735486 with itself or another soybean variety and plants produced by such methods.

Abstract: The invention relates to the soybean variety designated 4092390. Provided by the invention are the seeds, plants and derivatives of the soybean variety 4092390. Also provided by the invention are tissue cultures of the soybean variety 4092390 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety 4092390 with itself or another soybean variety and plants produced by such methods.

Abstract: The invention relates to the soybean variety designated 4858197. Provided by the invention are the seeds, plants and derivatives of the soybean variety 4858197. Also provided by the invention are tissue cultures of the soybean variety 4858197 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety 4858197 with itself or another soybean variety and plants produced by such methods.

Abstract: The invention relates to the soybean variety designated 4735316. Provided by the invention are the seeds, plants and derivatives of the soybean variety 4735316. Also provided by the invention are tissue cultures of the soybean variety 4735316 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety 4735316 with itself or another soybean variety and plants produced by such methods.

Abstract: The invention relates to the soybean variety designated 0385457. Provided by the invention are the seeds, plants and derivatives of the soybean variety 0385457. Also provided by the invention are tissue cultures of the soybean variety 0385457 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety 0385457 with itself or another soybean variety and plants produced by such methods.

Abstract: Basically, this invention provides for an inbred corn line designated G06-NP2598, methods for producing a corn plant by crossing plants of the inbred line G06-NP2598 with plants of another corn plants. The invention relates to the various parts of inbred G06-NP2598 including culturable cells. This invention also relates to methods for introducing transgenic transgenes into inbred corn line G06-NP2598 and plants produced by said methods.

Abstract: Broadly this invention provides an invention which is an inbred corn line G06-NP2739. The methods for producing a corn plant by crossing the inbred line G06-NP2739 are also encompassed by the invention. Additionally, the invention relates to the various parts of inbred G06-NP2739 including culturable cells. This invention relates to hybrid corn seeds and plants produced by crossing the inbred line G06-NP2739 with at least one other corn line.

Abstract: According to the invention, there is provided seed and plants of the corn variety designated I291859. The invention thus relates to the plants, seeds and tissue cultures of the variety I291859, and to methods for producing a corn plant produced by crossing a corn plant of variety I291859 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety I291859 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety I291859.

Abstract: According to the invention, there is provided seed and plants of the hybrid corn variety designated CH071844. The invention thus relates to the plants, seeds and tissue cultures of the variety CH071844, and to methods for producing a corn plant produced by crossing a corn plant of variety CH071844 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH071844.

Abstract: A nanotube transistor, such as a carbon nanotube transistor, may be formed with a top gate electrode and a spaced source and drain. Conduction along the transistor from source to drain is controlled by the gate electrode. Underlying the gate electrode are at least two nanotubes. In some embodiments, the substrate may act as a back gate.

Abstract: A capo for Dobro® and slide guitars, and other raised-string instruments is lever-operated and compression adjustable, enabling one-handed placement and removal and precise, consistent chord formation.

Abstract: A protective cap for the mouthpiece of a musical instrument includes a cap body fitting over the mouthpiece tip and an extension that is positively captured by a ligature normally holding the reed for the mouthpiece. The cap is designed to replace the reed when the instrument is left idle.

Abstract: A stringed instrument microphone which is particularly optimized for many players of stringed instruments is disclosed. Uniformity and faithfulness of the electrical output is provided by employing a high-quality microphone mounted by a fraction to the sound box at a fixed position in which it does not interfere with the playing of the instrument. At the same time gone variation of this position is accommodated with a structure which maintains position rigorously. This is important because infinitesimally small variations in position will produce clearly audible distortions. In accordance with the invention it has been discovered that such variations may be caused, among other factors, by vibration of the sound box, a flexible or otherwise displaceable bracket structure and resonance in the bracket.

Abstract: A universal mount for acoustically coupling a musical instrument tuner to an instrument has a link connected to the tuner at one end, the link adapted and arranged to have selectable loose and fixed states, with the link including complementary first and second clamping halves joined by a compression element, and a clamp connected to the other end of the link for acoustically coupling the tuner to the musical instrument.

Abstract: In an electronic music apparatus system, a unique musical instrument ID is stored in an electronic musical instrument by means of a plant computer before shipment thereof. After purchase of the electronic musical instrument, a user transmits the stored musical instrument ID to a management computer via a network without use of any intermediate device or by use of a user computer or a user portable communication terminal and performs user registration. By use of the musical instrument ID, the user downloads a program or content item suitable for the electronic musical instrument from a program distribution computer or a contents distribution computer via the network.

Abstract: With a decimal-fraction address representing a position between two continuous sample values and input from a decimal-fraction address calculation block (5-2) assumed as x, a product-sum block (5-5) calculates the value of x(1?x) as the sum of exclusive logical sums by approximating the value of (1?x) with a value obtained by inverting the values of all the bits representing x. With the use of the thusly obtained value, the waveform sample value (the waveform value) at a waveform position designated by the decimal-fraction address x is calculated, and time-divided DCO outputs are generated by using the calculation result and output to an accumulation block (5-6).

Abstract: A plurality of client-side electronic musical apparatuses 10 are connected to a server-side electronic musical apparatus 30 through a communications network 50. Each of the client-side electronic musical apparatuses 10, which is provided with an ID, attaches the ID to a signal representative of operation of performance operators 11 and setting operators 12, and transmits the ID-added signal to the server-side electronic musical apparatus 30. The server-side electronic musical apparatus 30 independently and concurrently executes, through the use of the ID, processes corresponding to the operational signals for the respective client-side electronic musical apparatuses 10 to generate musical tone data and display data, and transmits the generated data with the ID to the respective client-side electronic musical apparatuses 10. The thus-transmitted data is appropriately received by the client-side electronic musical apparatus 10 identified on the basis of the ID.

Abstract: A metronome for use by a musician or group of musicians generally includes a signal generator for producing an electrical signal according to a desired timing scheme and one or more transducers in wireless communication with the signal generator. Each transducer, which may take the form of a piezoelectric device, a buzzer, electrodes or any substantial equivalent, is adapted to impart a sensation to the musician in response to the generated electrical signal. The wireless communication may be established with an infrared link or a radio frequency transmission system. The signal generator is under the centralized control of a conductor, bandleader, lead musician or music instructor.

Abstract: Black/white keys are selectively moved by key actuators energized with a driving signal in a playback mode, and plunger sensors, which are provided inside of the key actuators, report the measured values of the keystroke to a motion controlling section; since the measured values contain error due to the deformation of the keys, the motion controlling section estimates true values or estimated values of the keystroke by dividing the sum of products between the measured values and weighting factors by a normalizing constant, and compares the estimated values with target values to see whether or not the keys exactly travel on reference trajectories; if the answer is negative, the motion controlling section varies the duty ratio of the driving signal so as to accelerate or decelerate the keys.

Abstract: An information processing apparatus comprises an operating member used for changing a sound volume, a display device which displays volume data of the sound volume changed in response to an operation of the operating member and a controller which changes the volume data. An indicator indicates level data changed in response to the operation of the operating member.