Abstract: Stable formulations of selective 5-hydroxytryptamine receptor antagonists for oral spray administration for absorption by the oral mucosa and related methods of preparation and administration are provided. A preferred embodiment includes ondansetron in a concentration of about 5.1 to about 5.2% w/w; propylene glycol in a concentration of about 60.1 to about 60.3% w/w; water in a concentration of about 5.3 to about 5.4% w/w; and ethanol in a concentration of about 27.1 to about 27.3% w/w. Additional preferred embodiments are preservative free and/or non-aqueous or primarily non-aqueous.

Abstract: An object of the present invention is to provide a method for easily producing coated fine particles in which core fine particles are coated with a coating layer component, etc. There are provided a method of producing coated fine particles comprising core fine particles coated with a coating layer component, comprising the steps of dispersing the core fine particles and the coating layer component(s) in a liquid and the process of coating the core fine particles with the coating layer component, wherein the liquid contains a polar organic solvent in which the coating layer component(s) is soluble, and the concentration of the polar organic solvent is such that the core fine particles is not dissolved and the coating layer component(s) can be in the dispersed state in the liquid, and the like.

Abstract: There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble therapeutic or diagnostic agent particles having a surface modifier on the surface thereof. There is also disclosed a method for making the aerosol and methods for treatment and diagnosis using the aerosol.

Abstract: A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient.

Abstract: The present invention concerns the use of oxygen antagonists for inducing stasis in cells, tissues, and/or organs in vivo or in an organism overall. It includes methods and apparatuses for achieving stasis in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, therapeutic methods and apparatuses for organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia, and cancer is provided.

Abstract: The invention relates to the treatment of burn injuries. Described are methods for modulating a burn injury in a subject, the method comprising providing the subject with a gene-regulatory peptide or functional analogue thereof. Also described is the use of an NF-kappaB down-regulating peptide or functional analogue thereof for the production of a pharmaceutical composition for the treatment of burn injury of a subject.

Abstract: The present invention discloses a dipeptide that is useful for the prevention or treatment of impaired neurovascular blood flow. The invention teaches that administration of carnosine-related compounds reduce focal ischemia (i.e., for example, stroke) symptomology whether administered before, or after, the impaired blood flow.

Abstract: A method for decreasing nicotine and other substance use in humans is disclosed. Tetrahydroberberine (THB) and its analogs, l-Tetrahydropalmatine (l-THP) and l-Stepholidine (l-SPD), are present in and can be isolated from several plants in the Magnoliidae superorder. According to the disclosed method, THB and its analogs are used to block nicotine-induced DA release, and modulate heterologous or homoeric expression of human nicotinic acetylcholine receptors (nAChR) in humans. Specifically, THB exhibits bi-directory modulation of ?4?2-nAChR-mediated currents induced by nicotine. THB also shows predominant inhibition on homologously expressed ?7-nAChR function. Thus, according to the disclosed method, THB is used to simultaneous blockade midbrain DA system function, the brain reward center, and neuronal ?4?2- and ?7-nAChR function, the major nicotine targets in the brain. Therefore, THB and its analogs serve as a novel class of natural compounds to decrease nicotine dependence in humans.

Abstract: The invention relates to a pharmaceutical composition and the use of same for treating diseases that are caused by microorganisms, and as a cosmetic. In one embodiment, the pharmaceutical composition comprises an extract of liquorice root and oak bark in combination with dexpanthenol.

Abstract: A locking system for a cotton candy machine includes a pair of rotatable cam members that are selectively engagable and disengagable from a motor mount of the machine to alternatively lock and unlock the machine. A rotatable handle or a pair of rotatable levers are operatively connected to the cam members to selectively rotate the cam members to the locked and unlocked positions.

Abstract: A device for the production of confectionery, in particular, pralines, in moulds, with at least one upper die which may be lowered relative thereto, mounted on a die plate whereby the die plate has a flexible mounting.

Abstract: An injection molding melt-conveyance system for conveying a molten molding material from an injection machine to an injection mold. The injection molding melt-conveyance system includes a first component having a first melt-channel and further includes a second component having a second melt-channel. A constant-force seal spring urges the first and second components toward one another so as to effect a seal that inhibits molten material flowing between the first and second melt channels from leaking through the seal. The constant force seal spring includes one or more Belleville springs each having an available deflection to thickness ratio chosen to provide that Belleville spring with a substantially constant spring force over a wide range of deflection.

Abstract: Methods and devices for manufacturing a conduit for placing a target vessel in fluid communication with a source of blood, such as a heart chamber containing blood. The conduit includes first and second portion adapted to be placed in fluid communication with a heart chamber and a target vessel. The conduit lies on the exterior of the myocardium between the blood source and the target vessel and delivers blood in multiple directions within the lumen of the target vessel. The conduit, which may be formed of any suitable synthetic vascular graft material, is generally T-shaped with the leg having two free ends disposed in the target vessel, preferably being secured thereto via a suture-free attachment. The conduit comprises vascular graft material and may be manufactured various ways, such as molding a conduit from any suitable biocompatible material or fabricating a conduit from one or more pieces of vascular graft material.

Abstract: Lactobacillus strains that have a genetic Profile I based on Apa I, Not I, and Xba I digests are provided. Preferably, the strains decrease level of at least one of coliforms and E. coli within the gastrointestinal tract of an animal. A direct-fed microbial that includes the strain is additionally provided. A method of feeding an animal the strain and a method of forming a direct fed microbial that includes the strain is also provided.

Abstract: Disclosed is a novel healthy and functional food having an obesity-suppressing activity. The healthy and functional food according to the present invention is manufactured by using an extract or a raw juice of purple-colored potato as a main/minor ingredient, or by adding the extract or a raw juice of purple-colored potato to various favorite foods. The extract of purple-colored potato according to the present invention has an obesity-suppressing activity by preventing an adipose cell from being differentiated and reducing leptin protein aiding to differentiate into adipose cells, and has an ability to reduce free fatty acid which is a hyperlipidemia-inducing factor and cholesterol in blood. Therefore, the healthy and functional food containing the extract of purple-colored potato according to the present invention can be useful to treat obesity patients including a wide age group of teenagers and adults and old persons.

Abstract: The present invention deals with the production of food products with a health promoting effect, namely immune modulation in general, and lowering and/or stabilizing blood sugar levels. The food products concerned comprise polysaccharides from edible or medicinal mushrooms. These are produced through fermentation instead of conventional cultivation of mushrooms. Fermentation process is preferably done in submerged cultures, especially fed-batch or step-up cultures.

Abstract: A process for preparing yoghourt without microbial contamination, especially aseptic packing technique for yoghourt. The aseptic canning process is divided into two steps of sterilizing milk and aseptic canning, and one inoculated lactobacillus milk tank is connected between the said two steps. Inside aseptic room, the inoculated lactobacillus milk tank is opened to introduce lactic acid bacteria and is whipped equably, then the lactobacillus milk enters aseptic canning apparatus by aseptic route so as to obtain yoghourt with lactic acid bacteria only and capable of being maintained for 2-3 months.

Abstract: The present invention provides novel strains of probiotics for use in the gastrointestinal tract of a pet. The probiotics of the present invention are capable of fermenting starch to produce lactic acid and/or hydrogen peroxide anti-pathogenic metabolites. The present invention also provides a novel method for identifying the effectiveness of a pet probiotic in vitro. The method simulates the introduction of a probiotic candidate in the gastrointestinal tract of a pet and measures the anti-pathogenic effectiveness of the probiotic.

Abstract: A method of creating jerky formulations through a nutraceutical marinade that result in the creation of sports enhanced supplemental jerky. This allows individuals to supplement their nutraceutical intake while traveling or participating in athletic activities without storing or transporting supplements or liquids required to take supplements.

Abstract: The invention pertains to a kit for preparing a coffee beverage, in particular cappuccino, cafe latte, or Wiener melange or the like, comprising a first container (1) holding at least a coffee beverage ingredient, preferably at least a coffee concentrate, a creamer and/or a foamer, to be dispensed into a receptacle and a second container (2) holding ground coffee.

Abstract: A cap assembly includes a body, a punch assembly, a safety ring and a connector strip. The body has a cap connector, a primary tube, a cover, a drive tube and a chamber. The primary tube is formed coaxially on the cap connector and has at least one annular seal. The drive tube is mounted on the cap connector and has multiple outer pawl teeth and multiple top pawl teeth. The punch assembly includes a drive cap, a punch tube and multiple upper teeth corresponding to the top pawl teeth. The punch tube is formed coaxially on and extends down from on the drive cap, is longer than the body and presses against the at least one annular seal. The safety ring is connected to the cap connector. The connector strip is connected to the punch assembly and has multiple inner pawl teeth engaging the outer pawl teeth.

Abstract: A solids package 10 comprises a linear elongate tubular structure 15 which is sealed at an upper end 11 and a lower end 12 thereof, the structure including an integral gripping portion 14 proximate the upper end and a foraminous portion 16, a predetermined amount of a solid material contained within the tubular structure 15, the solid material having a particle size greater then the openings in the foraminous portion, the structure having sufficient overall rigidity so as to permit at least the foraminous portion to be immersed in a liquid and by holding the gripping portion 14, stirring the package so as to cause the solid material to be dispersed, dissolved or infused into the liquid.

Abstract: An assembly of solid pieces of confectionery which is edible and can be hygienically played as a puzzle anywhere, anytime, e.g. outdoors and in cars. The solid pieces of confectionery may be first and second candy pieces. The first candy piece 1 is formed with a through hole 2. The second candy piece 3 is a columnar one which can be snugly fitted in the through hole 2 formed in the first candy piece. The second candy piece 3? may have a slightly larger diameter than the through hole of the first candy piece. In this case, the user can melt the surface of the second candy piece in his mouth to reduce its diameter until it can be fitted in the through hole of the first candy piece.

Abstract: A first pattern (64) of candy beads (14) is picked up by use of a vacuum carrier (54) and is positioned on a region of the upper surface of a sheet candy member (12). The vacuum is turned off and the vacuum carrier (54) is moved away from the sheet candy member (12) leaving the pattern (64) of candy beads (14) on the sheet candy member (12). This procedure is repeated at least once, and preferably two more times, providing an additional pattern or pattern of different colored candy beads (16, 18) on the upper surface of the base candy member (12). The color of the base candy member (12) and the color of the different candy beads (14, 16, 18) together form a picture or a design on the sheet candy member (12).

Abstract: A frozen confectionery product is provided comprising a plurality of discrete frozen confections, each discrete frozen confection being able to contact directly other discrete frozen confections in the product, which discrete frozen confections comprise an ice structuring protein (ISP) and have an average volume of at least 1 ml.

Abstract: A description is given of a whitish whole flour and a process for producing said flour, whereby said process involves: (a) supplying a quantity of conditioned wheat grain; (b) fractionating the wheat grain to obtain endosperm, bran, and germ; (c) separating and distributing the endosperm, bran, and germ to allow them to be treated; (d) milling the endosperm that is obtained in step (c) in order to homogenize the particle size to approximately 150-180 microns; (e) treating the germ in order to reduce the reactivity of the lipids contained therein; (f) treating the bran obtained in step (c) by: (f-i) separating the stream of bran coming from step (c) in order to produce a fine bran and a coarse bran, and (f-ii) milling the coarse bran from step (f-i) in order to obtain a pulverized bran with a particle diameter of approximately 180 microns; (g) mixing the endosperm from step (d), the germ from step (e), the fine bran from step (f-i), and the pulverized bran from step (f-ii) in a measurable and controlled manner

Abstract: A method of treating food capable of easily softening or pulverizing food in a short time without losing nutrients is provided. A shock wave (SW) generated in a shock wave source is applied to food such as an apple or tea leaves to soften or pulverize the food. A large mechanical load is not necessary, so the food is easily softened or pulverized. Moreover, it is not necessary to heat the food, so the food is softened or pulverized in a short time without losing nutrients in the food due to heat during heating.

Abstract: A method to pasteurize pre-packaged food at, or near room temperature, using supercritical carbon dioxide is provided. Carbonation may also be introduced simultaneous to the pasteurization.

Abstract: The present invention is generally directed to methods for reducing microbial population on food, especially seafood, during processing. Provided are methods of seafood processing that involve contacting seafood with a disinfection composition comprising an acid, a buffer, and an antimicrobial metal. Such methods can result in reduced pathogen load, reduced spoilage odor, and prolonged shelf-life of seafood. Also provided are systems for seafood processing employing said disinfectant compositions.

Abstract: Bipolar membrane electrodialysis (BMED) was used to separate lipids from biological solutions. The lipids are separated from animal as well as vegetable solutions. Particularly, bipolar membrane precipitates high levels of lipids from a biological solution. The BMED single step process improves significantly lipid precipitation rates in several biological solutions of different natures.

Abstract: The disclosure relates to a method in the protein fractionation of skim milk by means of microfiltration. The skim milk is pre-treated in that, before the microfiltration, it is heated to between 55 and 65 C and kept at this temperature for between 2 and 15 minutes. Thereafter, the skim milk is caused to pass through one or more microfilters, in which event the skim milk displays a falling or alternatively maintained temperature curve.

Abstract: A dough conditioning apparatus for frozen dough including: an enclosure; at least one tray or conveyance for supporting at least one frozen dough piece within the enclosure; a means to direct a conditioning gas directly onto frozen dough within the enclosure; humidity and temperature sensors for respectively measuring the humidity and temperature of the conditioning gas; and a gas controller, the gas controller controlling the duration of the conditioning gas onto the frozen dough according to the output of the humidity and temperature sensor.

Abstract: A folding tool onto which one places a fortune cookie crepe and a fortune ticket, while the crepe is still soft and pliable, which one then bends at hinges of the tool in a specific sequence, to cause the folding of the crepe around the fortune ticket and into a traditional fortune cookie shape before the crepe begins to permanently harden into its thus-formed shape.

Abstract: Cone-shaped food items and cones having various food stuffs in them are cooked by placing a cone-shaped food item into a cone-shaped heating station that travels through an oven and past an inclined heater element. The heating station rotates the cone-shaped food item so that it is uniformly heated as it passes through the oven.

Abstract: Dihydrocoumarin produced technologically from coumarin by biotransformation is claimed together with related production variants that are carried out with the aid of isolated enzymes and/or microorganisms. Pure coumarin as well as coumarin isolated from a plant extract or coumarin-containing plant extracts can be used as starting materials. Selected strains of Saccharomyces, Arthrobacter, Pseudomonas, Bacillus, Basidiomycetes and Fusarium can be directly used for the biotransformation or can provide the enzymes required for the biotransformation. Preferred enzymes are coumarate and coumarin reductases. A production variant is additionally claimed which starts with coumarin and which, via o-coumaric acid or via intermediary dihydrocoumarin, leads to the subsequent melilotic acid which is subsequently dehydrated to dihydrocoumarin.

Abstract: An all natural zero and low calorie sweetener composition is disclosed, which can be supplemented with calcium. The disclosed sweetener can be used in foodstuffs including food, beverages, and beverage products as a substitute for high calorie sweeteners along with calcium supplementation.

Abstract: Methods are provided to prepare heat stable soy milk concentrates above 3.2× based on the level of protein that are thermally stable upon achieving an Fo of at least 5. One method removes soluble carbohydrates prior to concentration. Another method removes both soluble and insoluble carbohydrates prior to concentration. Yet other methods prepare soy milk concentrates using partially hydrolyzed soy protein isolate.

Abstract: This application provides a process for producing a refried bean product. The refried bean product contains both homogenized cooked bean particles and larger sized cooked bean particles and provides a texture typical of refried beans. The present process includes hydrating dried beans in water a period of time sufficient to increase the moisture content of the beans, cooking the hydrated beans in water, coarse grinding the cooked beans to provide a bean slurry, dividing the bean slurry into first and second portions, milling the first bean portion to provide a milled bean portion, homogenizing the milled bean portion with water to provide an homogenized bean portion, combining the homogenized portion and the second coarse ground bean portion with water, spices and lard to provide a combined bean mixture, and mixing the combined bean mixture to provide a refried bean product.

Abstract: A process for producing a potato product includes hermetically enclosing potatoes in a container having an average oxygen permeability of 5 cc/m2·day·atm or less, and heating the potatoes at 60 to 95° C., the potatoes being heated under conditions where dissolved oxygen content in the container becomes 5% O2 or less at least when heating is completed.

Abstract: Disclosed is a crème filling that is fortified with the omega-3 fatty acids eicosapentaenoic acid, docosahexaenoic acid, or a mixture thereof and is room temperature stable for at least 4 months and more preferably for at least 8 months. It has been found that these omega-3 fatty acids can be stabilized by using in the crème filling a stabilizer fat and/or oil having a high saturated fat level of from 30 to 55%. The crème filling finds wide use in a variety of food products and provides the health benefits of omega-3 fatty acids to these foods.

Abstract: Disclosed herein are methods of coating an implantable device comprising applying a composition to the device in a predetermined pattern. The composition is then set to form a monolith. The composition applied can comprise a biodegradable polymer linked to a chemical moiety through a covalent bond, wherein the chemical moiety forms a pharmaceutically active agent upon degradation of the covalent bond.

Abstract: Medical catheters are often coated, fully or partially. The present invention relates to systems and methods for coating some portion or all of a medical catheter or one or more of its components.

Abstract: A disclosed substrate processing apparatus comprises a heat exchange plate configured to heat and/or cool the substrate; plural protrusions provided on the heat exchange plate so as to allow the substrate to be placed on the plural protrusions, leaving a gap between the substrate and the heat exchange plate; a suction portion configured to attract the substrate onto the plural protrusion by suction through plural holes formed in the heat exchange plate; and a partition member that is provided on the heat exchange plate and lower than the plural protrusions, wherein the partition member is configured to divide the gap into two or more regions including at least one of the holes so that at least one of the two or more regions is two-dimensionally closed by the partition member.

Abstract: An evaporation apparatus that is capable of determining the amount of organic material that is used for deposition of an organic layer (e.g. in an OLED) is presented. The apparatus evaporates an organic material through multiple stages and and includes: an evaporation source that evaporates the organic material and includes a heat source, a substrate supporter that supports a substrate, a sensor that senses a degree of evaporation of the organic material, a controller that calculates a deposition thickness of the organic material that is deposited during the stabilization stage, the deposition stage and the cooling stage by using the degree of evaporation sensed by the sensor, and a usage amount calculator that calculates a usage amount of the organic material by using a conversion factor between the deposition thickness of the organic material and the usage amount of the organic material, and the deposition thickness calculated by the controller.

Abstract: The invention relates to a method for producing c-plane GaN substrates or AlxGa1-xN substrates using an original substrate. Said method is characterized by the following steps: a tetragonal (100)-oriented or (?100)-oriented original LiAlO2 substrate is used; said original substrate is nitrided in a nitrogen compound-containing atmosphere at temperatures lying below the decomposition temperature of LiAlO2; a nucleation layer is grown at temperatures ranging between 500° C. and 700° C. by adding GaCl or AlCl or a mixture of GaCl and AlCl in a nitrogen compound-containing atmosphere; single-crystalline c-plane-oriented GaN or AlxGa1-xN is grown on the nucleation layer at temperatures ranging between 900° C. and 1050° C. by means of hydride vapor phase epitaxy (HVPE) with GaCl or AlCl or a GaCl/AlCl mixture in a nitrogen compound-containing atmosphere; and the substrate is cooled.

Abstract: A microfluidic device and method for capacitive sensing. The device includes a fluid channel including an inlet at a first end and an outlet at a second end, a cavity region coupled to the fluid channel, and a polymer based membrane coupled between the fluid channel and the cavity region. Additionally, the device includes a first capacitor electrode coupled to the membrane, a second capacitor electrode coupled to the cavity region and physically separated from the first capacitor electrode by at least the cavity region, and an electrical power source coupled between the first capacitor electrode and the second capacitor electrode and causing an electric field at least within the cavity region. The polymer based membrane includes a polymer.

Abstract: A method and apparatus for applying a solid particulate powder coating to a stator stack having a plurality of longitudinally extending stator slots. The apparatus includes a coating application station for applying powder particles to the stator stack, a coating removal station for displacing the powder particles from selected areas of the stator stack and a curing oven for curing the powder particles onto the stator stack. A collection hopper is provided for receiving recycled powder particles and includes a porous structural side wall for permitting air to exit the hopper while retaining the powder particles from passing into the environment around the system.

Abstract: A composition of matter and a structure fabricated using the composition. The composition comprising: a resin; polymeric nano-particles dispersed in the resin, each of the polymeric nano-particle comprising a multi-arm core polymer and pendent polymers attached to the multi-arm core polymer, the multi-arm core polymer immiscible with the resin and the pendent polymers miscible with the resin; and a solvent, the solvent volatile at a first temperature, the resin cross-linkable at a second temperature, the polymeric nano-particle decomposable at a third temperature, the third temperature higher than the second temperature, the second temperature higher than the first temperature, wherein a thickness of a layer of the composition shrinks by less than about 3.5% between heating the layer from the second temperature to the third temperature.

Abstract: Siloxane polymer compositions and methods of manufacturing a capacitor are described. In some embodiments, a mold layer pattern is formed on a substrate having a conductive structure, and the mold layer pattern has an opening to expose the conductive structure. A conductive layer is formed on the substrate. A buffer layer pattern is formed on the conductive layer formed in the opening. The buffer layer pattern includes a siloxane polymer represented by the following Chemical Formula 1. The conductive layer is selectively removed to form a lower electrode. The mold layer pattern and the buffer layer pattern are removed. A dielectric layer and an upper electrode are formed on the substrate to form a capacitor. The methods may simplify manufacturing processes for a capacitor and a semiconductor device, and may improve their efficiencies.

Abstract: A printed wiring board comprising an insulating film, a wiring pattern formed on at least one surface of the insulating film, a metal plating layer on the wiring pattern, and a resin protective layer provided on the wiring pattern with the metal plating layer in between so as to expose terminal portions of the wiring pattern plated with the metal, wherein the metal plating layer on the wiring pattern has a surface roughness (Rz) of 1.1 ?m or above. A semiconductor device includes the printed wiring board and an electronic component mounted thereon. In production of the printed wiring board, the wiring pattern is surface roughened prior to forming the metal plating layer such that the metal plating layer formed thereon will have a surface roughness (Rz) of 1.1 ?m or above.