Abstract: Novel salicylic anilides are chemical uncouplers useful e.g. for the treatment of obesity.

Abstract: The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting.

Abstract: The present invention relates to a process for suppressing the foaming which may occur at the time of the preparation of a solution or a suspension. Particularly, the present invention relates to pharmaceuticals, foods, and the like wherein the foaming at the time of the preparation of a solution or a suspension, which may cause any disadvantage, is suppressed.

Abstract: A nutritional supplement comprising at least a therapeutically effective amount of ethyl pyruvate and a therapeutically effective amount of at least one ?-hydroxy branched-chain amino acid metabolite is provided by the present invention. The ingredients of the present nutritional supplement substantially simultaneously act to induce a anabolically-favorable state for muscle by substantially simultaneously maintaining blood and muscle physiological pH levels as well as increasing cellular concentrations of branched-chain amino acids. Both a composition and a method are provided by the present disclosure.

Abstract: The administration of nutritional supplements such as phosphatidylcholine; linoleic acid and alpha linolenic acid in an approximately 4:1 (v/v) ratio; and mineral supplements provides an effective method for the treatment of ALS. Subjects presenting with symptoms indicative of ALS can therefore be treated with these nutritional supplements to inhibit progression of ALS. Subjects at risk for developing ALS can also be treated with these nutritional supplements to delay the onset of ALS symptoms.

Abstract: Herein are disclosed an excellent collagen synthesis-promoting amino acid composition that are characterized by containing specific amino acids at a specific ratio, more specifically, by containing 10-40 parts by weight of L-arginine and/or 10-40 parts by weight of L-glutamine, as well as 5-20 parts by weight of L-valine, 8-30 parts by weight of L-isoleucine and 10-35 parts by weight of L-leucine, an amino acid composition that inhibits skin aging, an amino acid composition that suppresses osteoporosis, an amino acid composition that promotes regeneration of tendon and ligament, and an amino acid composition that heals wounds or thermal burns, that are of the same composition.

Abstract: Compounds that provide for sustained systemic concentrations of GABA analogs following oral administration to animals are disclosed. Pharmaceutical compositions including, and methods using, such compounds are also disclosed.

Abstract: N-(2-hydroxyalkanoyl)-N,N?-dialkylureas of general formula (1) are described A-X-(A)m??(1) where A: m=0 or m=1; when m=0, X=R??, where R?? is an aliphatic, cycloaliphatic, arylaliphatic radical, C1-C18; when m=1, X=—(CH2)n—, where n is an integer from 1 and 20, preferably from 2 to 6; R is chosen among H, and alkyl radicals C1-C8, possibly substituted with halogen atoms; R? is an aliphatic, cycloaliphatic, arylaliphatic radical, C1-C18; R? is chosen among H, aliphatic, cycloaliphatic, arylaliphatic radical, C1-C18. The preparation of said compounds is described, as well as the preparation of corresponding polymers.

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, R3, and ring B are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

Abstract: The present invention relates to the formulation and delivery of prostaglandin analogs to treat epithelial-related condition. In some embodiments, the compositions of the invention are used to stimulate hair growth. In some embodiments, the compositions of the invention are used to restore hair color to depigmented hair.

Abstract: The present invention comprises packaged enemas for the treatment of Inflammatory Bowel Disease (IBD), having substantially pure 5-ASA as the active ingredient, with a liquid carrier medium having a material avoidance of bowel irritant substances, such as anti-oxidants for the 5-ASA active ingredient, including such sulfites as potassium metabisulfite, for example, and contained within a sealed and substantially oxygen-free barrier package, which may preferably be formed of a foil/polymer laminate, and which package contains or otherwise includes an oxygen scavenger, such as a an oxygen scavenging sachet.

Abstract: Bupropion hydrobromide formulations as well as their use for the treatment of conditions is described.

Abstract: A foamable composition, containing a saccharide for use in the treatment of various disorders including: water, a saccharide, about 0.2% to about 5% by weight of a surface-active agent, about 0.01% to about 5% by weight of at least one polymeric agent selected from a bio-adhesive agent, a gelling agent, a film forming agent and a phase change agent, and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.

Abstract: A stable complex oil-in-water emulsion which is useful in the cosmetic, pharmaceutical or food fields. The stable complex oil-in-water emulsion is formed by the mixing of individual oil-in-water emulsions, each individual emulsion being obtained from an air/water pre-emulsion of a preferably-nonionic surfactant; a cosurfactant selected from hydrophilic compounds, preferably with at least one hydroxyl group selected from polyols; and an aqueous phase. A method of preparing a stable complex oil-in-water emulsion whereby individual oil-in-water emulsions, chosen for properties desired in the stable complex oil-in-water emulsion, are optionally diluted and mixed without exerting a shear force.

Abstract: The invention relates to a novel class of gelling agents, to a process of preparing said agents, to the use of said agents to prepare gels, and to the gels thus obtained. A gelling agent or thickener according to the invention comprises a core which is functionalized with three amino acid derived groups by means of an amide or urea linkage. It may be used to gelate or thicken numerous solvents.

Abstract: A method for making particles containing carboxyalkyl cellulose, comprising blending a carboxyalkyl cellulose and a galactomannan polymer or a glucomannan polymer in water to provide an aqueous solution; treating the aqueous solution with a crosslinking agent to provide a gel; drying the gel to provide a solid; comminuting the solid to provide a plurality of particles.

Abstract: Production of biodiesel from vegetable and animal oils with conversion of a by-product crude glycerol stream to methanol. The crude glycerol stream is combined with superheated steam and oxygen to produce a synthesis gas that is then passed to a methanol synthesis reaction zone to produce methanol.

Abstract: A process for the preparation of propylene and ethylene comprises subjecting a gaseous mixture of a dilution gas and a paraffinic feedstock boiling in the gas oil range and having an iso paraffin to normal paraffin ratio of between 2 and 5 to a thermal conversion step.

Abstract: The invention relates to a plant and a process for the production of foam in a continuous slabstock process in which the actual foam height profile is detected transversely to the feed direction and a correcting variable for the slabstock process based on deviation of the actual foam height profile from a desired foam height profile is determined.

Abstract: A foamed sheet of a base resin containing 50 to 100% by weight of a polylactic acid resin and having an apparent density of 63 to 630 kg/m3, a thickness of 0.5 to 7 mm and endothermic and exothermic calorific values of ?Hendo:2 and ?Hexo:2, respectively, as measured by heat flux differential scanning calorimetry at a heating rate of 2° C./min. The endothermic calorific value ?Hendo:2 is at least 10 J/g and the difference (?Hendo:2??Hexo:2) between the endothermic calorific value ?Hendo:2 and the exothermic calorific value ?Hexo:2 is less than 40 J/g. A foam molding such as a receptacle is prepared by thermoforming the foamed sheet.

Abstract: A lamellar crystalline organic polymer containing acidic groups and/or ammonium salt thereof, such as ammonium salt of polymuconic acid, is mixed with a substance containing a metal ion such as alkali metal ion, to prepare a metal ion-containing polymer having a structure in which the metal ion is intercalated between the layers of the lamellar crystalline organic polymer having acidic groups. Subsequently, metal ion exchange reaction is conducted if necessary. Thereafter, the metal ion is reduced to produce fine metal particles. Thus, a crystalline organic polymer in which fine metal particles are dispersed in a crystalline organic polymer is obtained.

Abstract: A poly(para-phenylenevinylene) (PPV) compound for forming a buffer layer of a thin film transistor represented by where R is a C1-C20 silyl group substituted with cyclohexyl or phenyl, m is an integer from 2 to 4, and n is an integer from 1 to 3,000; a composition for forming a buffer layer of a thin film transistor that is used to form the compound represented by formula 1 and includes a halo precursor polymer, a photobase generator, and a solvent; a thin film transistor including a buffer layer which is manufactured using the PPV compound; and a flat panel display including the thin film transistor. A patterned buffer layer can be formed under an organic semiconductor layer of an organic TFT by photolithography patterning using the silicon-containing PPV precursor. Accordingly, the alignment of the organic semiconductor layer of the organic TFT can be improved, and thereby, the characteristics of the organic TFT can be improved.

Abstract: The invention provides a pressure-sensitive adhesive for the skin excellent in pressure-sensitive adhesiveness to the human skin and repeelability therefrom, which does not cause the horny layer to be torn away in peeling and is lowly irritant to the skin; and tapes or sheets made by using the same. The pressure-sensitive adhesive is characterized by comprising (a) 100 parts by weight of a copolymer which is prepared from an olefinic macromonomer and a vinyl monomer and whose molecular weight (in terms of polystyrene and as determined by gel permeation chromatography (GPC)) has a two-peak distribution (with the proviso that when the copolymer is to be post-cured, the distribution is one as determined before the post cure) and (b) 20 to 250 parts by weight of a softener which is compatible with the copolymer and liquid or pasty at room temperature and has a boiling point of 250 or above (with the proviso that when the content of the softener (b) exceeds 80 parts by weight, the copolymer must be post-cured).

Abstract: A method for the production of cores and molds for casting molds, based on a base molding material and an organic or inorganic binding agent and an additive. According to the method, pre-forming substances are used in order to dispense with the use of sizing substances and to prevent the formation of ribs.

Abstract: The present invention provides fast-drying aqueous compositions that lower the cost of making roadway markings without impairing the quality or appearance of the markings made therewith. The aqueous compositions comprise one or more hollow core binder having an average particle size of from 200 to 500 nanometers (nm), preferably from 300 to 470 nm, and made of a first polymer having a glass transition temperature (Tg) of 50° C. or more and containing one or more void, the first polymer being substantially encapsulated by one or more second polymer having a Tg of ?30° C. or more, preferably, ?20° C. or more. Fast-drying aqueous compositions may be one component or two component compositions.

Abstract: Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula: {X—OOC—[(CH2)n—COO]m}p—Y??(I) wherein: X is a residue of a hydrophobic moiety, Y is a residue of a hydrophilic moiety, p is 1 or 2, m is 0 or 1, and n is an integer greater than or equal to 0 are disclosed. The lipophilic compound is preferably selected from the group consisting of water-insoluble ubiquinones, ubiquinols, vitamins, provitamins, polyene macrolide antibiotics, and mixtures thereof. The hydrophobic moiety is preferably a sterol or a tocopherol and the hydrophilic moiety is preferably a polyalkylene glycol. In some embodiments, the sterol is cholesterol or sitosterol, the tocopherol is ?-(+)-tocopherol, the polyalkylene glycol is a polyethylene glycol or its methyl monoether having an average molecular weight between 400 and 1000, p is equal to 1 or 2, m is equal to 0 or 1 and n is an integer between 2 and 18.

Abstract: Methods of cementing comprising: providing a cement composition comprising water, a cement, and a particulate elastomer comprising a carboxy group; and allowing the cement composition to set. Cement compositions comprising water, a cement, and a particulate elastomer comprising a carboxy group.

Abstract: The invention is related to the preparation of an ionic polymer composite material comprising a protein and carbohydrate-containing vegetable material component that serves as a reinforcement agent for the composite. In preferred embodiments of the invention, the vegetable seed component is selected from the group of soy spent flakes, defatted soy flour, or soy protein concentrate with ionic polymers and the ionic polymer is carboxylated poly(styrene-butadiene). The composites have a significantly higher elastic modulus when compared with base polymer.

Abstract: The present invention provides an extrudable resin-containing composition comprising at least saccharide ester, preferably according to Formula I. wherein “A” is hydrogen or has the structure of Structure I: wherein “R” is an aliphatic or aromatic moiety of about eight to about 40 carbon atoms, and wherein at least one “A” moiety of Formula I is a moiety of Structure I. Also provided are extrusion methods and extruded products based on the present compositions.

Abstract: In methods of preparing asphalt and elastomeric polymer compositions crosslinked with phenol aldehyde resins and sulfur, such as polymer modified asphalt (PMA), it has been discovered that the MP1 compatibility may be improved by adding certain ionic metal oxides. Suitable ionic metal salts include, but are not necessarily limited to, zinc oxide, cadmium oxide, and the like. Acceptable elastomeric polymers include, but are not necessarily limited to, styrene-butadiene copolymers. Additional sulfur-containing crosslinkers may also be used.

Abstract: The invention relates to moldings or molding compositions composed of polyoxymethylene and featuring very low formaldehyde emission, comprising from 0.1 to 50.0% by weight of a tribological modifier, from 0.01 to 0.5% by weight of a cyclic stabilizer which contains at least one nitrogen atom in the ring, and from 0.05 to 1% by weight of at least one ester composed of a polyhydric alcohol and of at least one (C10-C32) fatty acid, and also to their production and use.

Abstract: Process for preparation of polyoxymethylenes via polymerization of the monomers a) in the presence of cationic initiators b) and also, if appropriate, in the presence of regulators c), followed by deactivation and discharge from the reactor, which comprises using, as deactivator (d) at least one basic compound having at least 2 amino functions of different reactivity in one molecule.

Abstract: Disclosed is a biodegradable resin composition containing at least one biodegradable organic high molecular compound, a flame retardant additive containing a phosphorus-containing compound, and a hydrolysis suppressing agent suppressing the hydrolysis of the at least one biodegradable organic high molecular compound. An aliphatic polyester resin is polylactic acid, polycaprolactone, polyhydroxy lactic acid, polyhydroxy valeric acid, polyethylene succinate, polybutylene succinate, polybutylene adipate, polymalic acid, polyesters synthesized by fermentation, or a copolymer containing at least one of them. A polysaccharide is cellulose, starch, chitin, chitosan, dextrane, a derivative of at least one of them, or a copolymer containing at least one of them.

Abstract: The present invention provides for a color stable antimicrobial coatings and coating systems comprising a silver ion-exchange type antimicrobial agent. In particular, coatings and coating systems having little, if any, discoloration are provided with no loss of antimicrobial efficacy.

Abstract: A flame-retardant polyamide composition having excellent properties in mechanical properties such as toughness, in heat resistance, incombustibility and flowability in a reflow soldering process, and in heat stability during molding. There is provided a flame-retardant polyamide composition comprising 20 to 80% by mass of polyamide resin (A), 5 to 40% by mass of flame retardant with specific bromine content and molecular weight (B) and 0.5 to 10% by mass of flame retardant auxiliary agent (C) optionally together with hydrotalcite compound of specific composition (D).

Abstract: Latex-based compositions, and methods of forming the same, that are useful to dampen noise and vibrations, are disclosed. The compositions can be applied to and adhered to a substrate. The compositions comprise latex and at least one filler. The compositions form microcracks during drying and/or curing to aid in the removal of water from the compositions.

Abstract: An adhesive composition comprising an emulsion polymer which comprises a (meth)acrylate copolymer and silica nanoparticles is described. The addition of the nanoparticles results in a significant increase in the overlap shear properties of the adhesive while maintaining the peel adhesion.

Abstract: Monodisperse silica spheres containing polyamine, which comprise a polymer (A) having a linear polyethyleneimine chain, a compound (B) having an acidic group, and silica (C).

Abstract: Disclosed herein is an adhesive composition comprising: a random propylene polymer component having a heat of fusion of between 1 and 70 J/g and an mm triad tacticity index of at least 75%; and a functionalized polymer component comprising a C2-C20 olefin comprising at least 0.1 wt % of a functional group; wherein the adhesive composition has a T-Peel adhesion on a polar substrate at 20° C. of at least 175 N/m (1 lb/in) and a T-Peel adhesion on a non-polar substrate at 20° C. of at least 175 N/m Pa (1 lb/in) and where the polarity of the polar substrate is at least 0.10 units higher than the polarity of the non-polar substrate. Methods to produce the adhesive and articles comprising the adhesive are also disclosed.

Abstract: A polymer including a block chain A which is formed from a random copolymer containing a repeating unit (I) represented by the formula (I) wherein R1 to R3 each independently represents hydrogen or C1-10 hydrocarbon and R1 and R3 may bond to form a ring; R4a and R4b each independently represents hydrogen or methyl; R5 represents hydrogen, hydrocarbon, acyl, or silyl; and m represents any integer of 1 to 100 and when m is 2 or more and each R4a may be the same or different from one another and each R4b may be the same or different from one another; and a repeating unit (II) represented by the formula (II) wherein R6 and R8 each independently represents hydrogen or C1-10 hydrocarbon and R6 and R8 may bond to form a ring; R7 represents hydrogen, C1-10 hydrocarbon, hydroxyl, hydrocarbonoxy, carboxyl, acid anhydride, amino, ester, or an organic group having at least one functional group selected from the group consisting of hydroxyl, carboxyl, epoxy, acid anhydride, and amino; and R9 represents an

Abstract: Reactive hot melt adhesives compositions with long open time and/or high green strength are prepared by the use of urethane diols. These results are achievable at moderate/low application viscosity or low application temperature.

Abstract: A thermoplastic elastomer having adhesion to steels, where the thermoplastic elastomer includes a dynamically crosslinked rubber, from more than 2.0 to 10 parts of a metal oxide or salt, and from 10 to 200 parts by weight of a functionalized polyolefin having pendant polar functional groups, where the polar functional groups are present at a level of 0.5 to 3.5 mole percent of the total repeating units of said functionalized polyolefin and the functionalized polyolefin is derived from polymerizing at least one monoolefin to form a semicrystalline polymer or is derived from hydrogenating the polydiene blocks of a block copolymer, and where the parts by weight are based on 100 parts by weight of crosslinked rubber.

Abstract: Novel crosslinkable compositions based on elastomers, at least one of which has carboxyl and/or carboxylate groups, are provided, these crosslinkable compositions containing special unsaturated organic salts of metal ions and a crosslinking system which acts as a free radical donor. Crosslinked elastomers which have excellent physical properties are obtainable therefrom. The novel crosslinkable compositions have a wide range of uses.

Abstract: Disclosed is a method of polymerizing olefin using a compatible combination of a multi-site catalyst and a single-site catalyst. The catalysts may be a Ziegler-Natta catalyst and a metallocene catalyst. The resulting polymer, which may be a homopolymer or a random copolymer, may exhibit a molecular weight distribution which is intermediate than that resulting for polymers prepared using either catalyst alone.

Abstract: Blend compositions containing a novel homopolymer, the use of which allows the incorporation of more comonomer in the additional components of the blend (for the same overall density) resulting in increased tie molecule formation and improvement in properties such as ESCR, toughness and impact strength are disclosed. The homopolymers are important for applications where a high density is needed to ensure certain mechanical properties like abrasion resistance, indentation resistance, pressure resistance, topload resistance, modulus of elasticity, or morphology (for the chlorination of PE to CPE) and additional advantages such as melt processability. The blend can be obtained by dry or melt mixing the already produced components, or through in-situ production by in parallel and/or in series arranged reactors. These resins can be used in applications such as films, blow molded, injection molded, and rotomolded articles, fibers, and cable and wire coatings and jacketings and, various forms of pipe.

Abstract: A reactive extrusion process for producing an ionomer is disclosed. The process comprising adding a polymer containing a carboxyl functionality to an extruder, then homogenously melting the polymer in a melting zone of the extruder. A first melt seal zone of the extruder is formed to separate the melting zone from an injection zone where an aqueous solution of metallic ions are added to the molten polymer. The first melt seal zone is formed by increasing the pressure in the melt seal zone to a pressure which is higher than the vapor pressure of the water at any point in the injection zone and the reaction zone. The aqueous solution of metallic ions is then mixed with the polymer containing the carboxyl functionality in a reaction zone of the extruder under conditions such that the metallic ions are substantially reacted with the carboxyl functionality.

Abstract: A chlorinated propylene-based polymer of the present invention having a weight average molecular weight (Mw) as measured by gel permeation chromatography (GPC) of 5,000 to 100,000 and a chlorine content of 0.1 to 70% by mass has the following properties: (1) it has a high solubility in a non-aromatic solvent having a low environmental burden even when it has a low degree of chlorination, and (2) it can be inhibited from suffering a decrease in the properties inherent to polypropylenes, such as durability, mechanical properties, appearance and hydrophobicity, by regulating its degree of chlorination at a low value.

Abstract: A modified polyphenylene ether resin is provided which is a product of the reaction of 100 parts by weight of (A) a polyphenylene ether having a main chain structure of the following formula (1): (wherein R1 and R4 each independently represents hydrogen, a primary or secondary lower alkyl, a phenyl, an aminoalkyl or a hydrocarbonoxy, and R2 and R3 each independently represents hydrogen, a primary or secondary lower alkyl or a phenyl), with 0.01 to 10.0 parts by weight of (B) a modifier selected from conjugated non-aromatic diene compounds, dienophilic compounds having one dienophile group and precursors of the diene or dienophilic compounds, wherein the number of rearrangement structures each represented by the following formula (2): (wherein R1, R2, R3, and R4 have the same meanings as defined above in the formula (1)) is less than 0.01 per 100 phenylene ether units of the formula (1).

Abstract: A biodegradable mixture obtained by melt mixing polyesters comprising (A) an aliphatic polyester obtained from aliphatic diacids selected from the group consisting of azelaic acid, sebacic acid, brassilic acid, mixtures thereof and mixtures of said acids with aliphatic dicarbossilic acids and/or aliphatic hydroxyacids containing more than 50 mole % of azelaic acid, sebacic acid and brassilic acid, and from aliphatic diols; (B) a polymer of lactic acid in which the concentration by weight of A with respect to (A+B) is in the range of 30 to 60% and in which the sum of the fusion entalpy ?HA and ?HB of the two polyesters in the mixture is greater than the sum of the fusion entalpies ?H1 and ?H2 of the polyesters prior to melt mixing.

Abstract: A uniformly premixed sealant is extruded into a packaging form and allowed to pressure equilibrate prior to freezing. Upon warming the sealant begins to cure. The storage of the preformed sealant formulation under cold conditions arrests the activity of cure catalysts and accelerators mixed therethrough. The sealant is readily extruded into a preform shape containing a lightweight filler. A release film is provided to avoid contact with the sealant preformed in a shape during application to a substrate.