Patents Issued in January 19, 2010
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Patent number: 7648670Abstract: An apparatus for inverting the stop flange on a tamper-indicating closure, from an axially outwardly oriented position as molded to an axially inwardly oriented position for use, includes a support base for supporting the closure such that the stop flange as molded is spaced from and oriented away from the support base. A pedestal is movably carried by the support base at a position spaced from the support base. A locator ring is carried by the pedestal and movable with the pedestal to engage the stop flange on a closure carried by the support base and to bend the stop flange radially inwardly. An inversion ring moves through the locator ring to engage and invert the stop flange that is bent radially inwardly by the locator ring.Type: GrantFiled: November 8, 2007Date of Patent: January 19, 2010Assignee: Rexam Closure Systems Inc.Inventor: Daniel L. Mattice
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Patent number: 7648671Abstract: The method of the present invention includes an exposing step in which a laser beam for recording modulated by an information signal corresponding to an information signal of an information concave and convex pattern formed on the optical disc is applied to an inorganic resist layer 101 formed on a substrate 100 to form an exposed pattern corresponding to the information concave and convex pattern on the optical disc, and a development step in which a concave and convex pattern corresponding to the information concave and convex pattern by the inorganic resist layer is formed. By applying a laser beam for estimation to a predetermined area on the inorganic resist layer in the exposing step to estimate recorded signal characteristics of the exposed pattern by the inorganic resist layer using reflected light of the laser beam for estimation, and controlling power of the laser beam for recording based on the estimated result, the aimed information recording on the optical disc can reliably be obtained.Type: GrantFiled: November 20, 2003Date of Patent: January 19, 2010Assignee: Sony CorporationInventors: Shinichi Kai, Akira Kouchiyama, Katsuhisa Aratani, Kenzo Nakagawa, Yoshihiro Takemoto
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Patent number: 7648672Abstract: In a system for processing metal, a furnace is provided which receives the metal being processed. At least one heating burner is provided in the furnace together with at least one atmosphere burner of substantially a same construction as the heating burner. An exhaust of the atmosphere burner at least partially provides an atmosphere within the furnace for the metal processing. An exhaust of the heating burner is separate from the exhaust of the atmosphere burner. A fuel feed for the atmosphere burner and a fuel feed for the heating burner are each separately controllable.Type: GrantFiled: May 17, 2007Date of Patent: January 19, 2010Assignee: Tempel Steel CompanyInventor: Vahe Ohanian
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Patent number: 7648673Abstract: A process for denoxification of off-gases from annealing and pickling lines, providing for the off-gases from the pickling section to be heated and denoxified by selective catalytic reduction (SCR). In order to secure the meeting of lowest NOx values in the off-gas with the lowest possible expenditure, heat is supplied from the off-gases from the annealing furnace (1) to the off-gases from the pickling section (3) before the selective catalytic reduction (9).Type: GrantFiled: February 26, 2007Date of Patent: January 19, 2010Assignee: Andritz AGInventors: Ferdinand Reiter, Peter Van Gilst, Rodney Verkaart
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Patent number: 7648674Abstract: A single treatment compartment has a liquid metal inlet and outlet and a connection to a liquid metal-input trough. A treatment gas is injected into the liquid metal arranged in at least one sidewall of a ladles. The liquid metal inlet and outlet have an orifice positioned so as to be entirely underneath a level of the liquid metal during the treatment, in order to prevent entry of ambient air into the compartment during treatment. The treatment compartment includes an upstream part and a downstream part. The gas injection is accomplished in the upstream part. The compartment further has a filter located in the downstream part for degassing and filtering the liquid metal. Injection and filtration occur in close proximity to one another and within the same single treatment compartment.Type: GrantFiled: May 6, 2003Date of Patent: January 19, 2010Assignee: Novelis Technology AGInventors: Jacques Charpientier, Jean-Marie Château
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Patent number: 7648675Abstract: A method of sintering a composite body characterized by a transition metal carbide phase (such as a ZrC phase) substantially evenly distributed in a second, typically refractory, transition metal (such as W) matrix at ambient pressures, including blending a first predetermined amount of first transition metal oxide powder (such as ZrO2) with a second predetermined amount of second transition metal carbide powder (such as WC powder). Next the blended powders are mixed to yield a substantially homogeneous powder mixture and a portion of the substantially homogeneous powder mixture is formed into a green body.Type: GrantFiled: October 6, 2006Date of Patent: January 19, 2010Inventors: Shi C. Zhang, Gregory E. Hilmas, William G. Fahrenholtz
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Patent number: 7648676Abstract: The present invention is directed to the field of implants that include soft tissue. More particularly, the present invention is directed to processes for treating implants that include soft tissues such as tendons and ligaments, and to implants produced by such processes. The present invention is also directed to processes and apparatus for improved processing of implants that include soft tissue, by applying kinematic restraint, preferably tension, to the implant or specific portions of the implants during the treatment, and to implants produced by such processes and apparatus. The present techniques yield soft tissue implants having superior structural, mechanical, and/or biochemical integrity.Type: GrantFiled: April 20, 2004Date of Patent: January 19, 2010Assignee: RTI Biologics, Inc.Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, Chandrasekaran Nataraj
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Patent number: 7648677Abstract: Methods for operating a sensor device are provided, which may include (a) providing at a site (e.g., implanting in a patient) a device which comprises at least first and second reservoirs, a first sensor and corresponding first reference sensor located within the first reservoir, a second sensor and corresponding second reference sensor located within the second reservoir, a first reservoir cap closing an opening in the first reservoir and a second reservoir cap closing an opening in the second reservoir, and a power source, control circuitry, and electrodes for selectively disintegrating each reservoir cap; (b) disintegrating the first reservoir cap and operating the first sensor and reference sensor; and (c) using the first reference sensor to determine whether the first sensor is operating properly. If not operating properly, then the control circuitry initiates disintegration of the second reservoir cap and operation of the second sensor and reference sensor.Type: GrantFiled: October 29, 2007Date of Patent: January 19, 2010Assignee: MicroCHIPS, Inc.Inventors: John T. Santini, Jr., Norman F. Sheppard, Jr., Robert S. Langer, Chung Chang Young
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Patent number: 7648678Abstract: The present invention concerns a method and an apparatus for automatic staining of at least one tissue sample accommodated on a slide by applying reagents. The system may include at least one slide provided in a slide rack, a fluid containment element, a slide holder, a vertical slide positioner to pivot the slides to a vertical position, and a slide immerser element to immerse the vertical slide into a fluid containment element or even a dip tank. By pivoting the slides from a horizontal to a vertical position, an automated method and apparatus for carrying out a pretreatment in an automated staining apparatus may be provided. The pivoting of slides may ensure an appropriate orientation of the slides for both the pretreatment and the staining processes.Type: GrantFiled: December 8, 2003Date of Patent: January 19, 2010Assignee: DAKO Denmark A/SInventors: John Favuzzi, Benno Guggenheimer, Jeff Rau, Marc Key, Robert Lathrop, Rosanne Welcher
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Patent number: 7648679Abstract: The invention relates to an electric pipette (1) comprising a body (2), a tip part (4), a hook part (5), a push-button part (6) and a display part (7), said body (1) having a vertical axis (3) and at least one of the parts selected from the group consisting of the hook part (5), the push-button part (6) and the display part (7) is rotatable about the vertical axis (3) of the electric pipette (1) correspondingly by an angle ?1, ?2 or ?3.Type: GrantFiled: November 12, 2004Date of Patent: January 19, 2010Assignee: Thermo Fisher Scientific OyInventors: Juha Telimaa, Mikael Lind, Vesa Salo, Mauno Heinonen
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Patent number: 7648680Abstract: Method for obtaining a fluid sample from a collection device which includes assembling cap and fluid-holding vessel components of the collection device to contain and isolate a specimen retrieval device adjacent a side wall of the vessel. The position of the specimen retrieval device within the collection device is such that the specimen retrieval device does not substantially interfere with the movement of a fluid transfer device into or out of the assembled collection device. The fluid transfer device is used to draw and remove a fluid substance from the collection device for analysis.Type: GrantFiled: October 26, 2004Date of Patent: January 19, 2010Assignee: Gen-Probe IncorporatedInventors: Bruce W. Anderson, Nick M. Carter, Mordi I. Iheme, Daniel L. Kacian
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Patent number: 7648681Abstract: A system for collecting, transporting and preparing a fecal specimen for examination includes a container, a closure selectively secured over an open end of the container, and a sample collection member coupled to the closure and extending into the container when the closure is secured thereto. In one embodiment, the closure includes a base and a cap that are hingedly coupled together. The cap is selectively moveable between a closed position that seals an aperture in the base, and an open position wherein the aperture is exposed to permit expelling contents of the container through the aperture. In another embodiment, the closure comprises a base having a spout and an aperture, and a cap coupled to the base for axial movement along the spout between open and closed positions. The system may further include a deodorant to mask or absorb odors.Type: GrantFiled: December 1, 2004Date of Patent: January 19, 2010Assignee: Meridian Bioscience, Inc.Inventors: Kevin Jon Meyer, Betty Jo Smith
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Patent number: 7648682Abstract: The invention relates to an improvement in apparatus and process for effecting storage and delivery of a gas. The storage and delivery apparatus is comprised of a storage and dispensing vessel containing a medium capable of storing a gas and permitting delivery of the gas stored in the medium from the vessel, the improvement comprising: (a) a reactive liquid having Lewis acidity or basicity; (b) a gas liquid complex in a reversible reacted state formed under conditions of pressure and temperature by contacting the gas having Lewis acidity with the reactive liquid having Lewis basicity or the gas having Lewis basicity with the reactive liquid having Lewis acidity; (c) a non-reactive wick medium holding and dispersing the reactive liquid and the gas liquid complex therein.Type: GrantFiled: May 3, 2007Date of Patent: January 19, 2010Assignee: Air Products and Chemicals, Inc.Inventors: Wayne Thomas McDermott, Daniel Joseph Tempel, Philip Bruce Henderson, Ronald Martin Pearlstein
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Patent number: 7648683Abstract: A plasma generating electrode 1 of the present invention includes a plurality of unit electrodes 2 hierarchically layered at predetermined intervals, the unit electrodes 2 including a deficient unit electrode 2b in which a conductive film 4 has an absent portion and a normal unit electrode 2a in which the conductive film 4 does not have an absent portion. Spaces V formed between the unit electrodes 2 include a normal space Va formed so that the distance between conductive films 4 corresponds to the distance between the unit electrodes 2 and a deficient space Vb formed so that the distance between the conductive films 4 is greater than the distance between the conductive films 4 in the normal space Va. The plasma generating electrode 1 of the present invention can efficiently treat a plurality of predetermined components contained in a treatment target fluid by utilizing different types of plasma suitable for respective reactions by causing the treatment target fluid to flow only once.Type: GrantFiled: June 25, 2004Date of Patent: January 19, 2010Assignees: NGK Insulators, Ltd., Honda Motor Co., Ltd.Inventors: Yukio Miyairi, Yasumasa Fujioka, Masaaki Masuda, Tatsuhiko Hatano, Takeshi Sakuma, Yuuichiro Imanishi, Keizo Iwama, Kenji Dosaka
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Patent number: 7648684Abstract: The invention relates to a device for disinfecting liquids by means of ultraviolet radiation in a continuous flow method, with a reactor chamber through which flow can take place and in which a number of UV radiator units is arranged, the reactor chamber being provided with a wall, which is open at two end sides, and locally surrounded by at least one pre-chamber. Advantageous flow conditions are achieved if the at least one pre-chamber is welded to the wall at a distance from the end side so that an annular intermediate space with an internal width (r) is formed between a side of the per-chamber and the wall, and an essentially axisymmetric annular gap (d) is formed between the end side and the pre-chamber.Type: GrantFiled: August 25, 2005Date of Patent: January 19, 2010Assignee: Wedeco AGInventor: Dieter Neitemeier
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Patent number: 7648685Abstract: A process for hydroprocessing a hydrocarbon feed with a known flow rate of hydrogen-containing gas and a volume of catalyst, includes the steps of providing a hydrocarbon feed having an initial characteristic; feeding the hydrocarbon feed and a first portion of the hydrogen-containing gas cocurrently to a first hydroprocessing zone containing a first portion of the catalyst so as to provide a first hydrocarbon product; providing an additional hydroprocessing zone containing a remainder of the catalyst; feeding the first hydrocarbon product cocurrently with a remainder of the hydrogen-containing gas to the additional hydroprocessing zone so as to provide a final hydrocarbon product having a final characteristic which is improved as compared to the initial characteristic, wherein the first portion of the hydrogen-containing gas is between about 30 and about 80% vol. of the known flow rate of the hydrogen-containing gas, and the first portion of the catalyst is between about 30 and about 70% wt.Type: GrantFiled: July 19, 2002Date of Patent: January 19, 2010Assignee: Intevep, S.A.Inventors: Carlos G{dot over (u)}stavo Dassori, Nancy Fernandez, Rosa Arteca, Carlos Castillo
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Patent number: 7648686Abstract: A catalytic reactor including a heat exchanger and a method are provided for transferring heat to a coolant and a reaction fluid. The catalytic reactor includes a reaction fluid flow path, a reaction region, and a coolant flow path. A reaction fluid catalytically reacts at a surface area in the reaction region thereby generating heat. The heat is transferred to a coolant and the reaction fluid based on the coolant and reaction fluid convective heat transfer coefficients respectively. In one embodiment, the ratio of the coolant convective heat transfer coefficient to the reaction fluid heat transfer coefficient is at least 5:1.Type: GrantFiled: April 5, 2004Date of Patent: January 19, 2010Assignee: Modine Manufacturing CompanyInventors: Michael J. Reinke, Jeroen Valensa
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Patent number: 7648687Abstract: Purification techniques have been developed for ceramic powder precursors, e.g., barium nitrate. These techniques can be performed using one or more of the following operations: (1) removal of impurities by precipitation or coprecipitation and separation using a nonmetallic-ion-containing strong base, e.g., tetraalkylammonium hydroxides; (2) reduction of higher oxidation-state-number oxymetal ions and subsequent precipitation as hydroxides that are separated from the solution; and (3) use of liquid-liquid exchange extraction procedures to separate certain impurities.Type: GrantFiled: June 15, 2006Date of Patent: January 19, 2010Assignee: EEStor, Inc.Inventors: Richard D. Weir, Carl W. Nelson
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Patent number: 7648688Abstract: Disclosed herein is a method of separating carbon dioxide from a gas mixture using a biopolymer, including: introducing hemocyte or extrapallial fluid, extracted from shells, into a reactor filled with 1 L of a solution containing a calcium source, and then dissolving the hemocyte or extrapallial fluid in the solution to form a mixed solution; and mixing carbon dioxide or a gas mixture containing carbon dioxide into the mixed solution to separate carbon dioxide from the gas mixture.Type: GrantFiled: August 19, 2008Date of Patent: January 19, 2010Assignee: Korea Institute of Energy ResearchInventors: Soon-Kwan Jeong, Seung-Woo Lee, Si-Hyun Lee, Cheong-Song Choi, Sang-Do Kim
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Patent number: 7648689Abstract: The invention is to provide a process for industrially advantageously producing InP fine particles having a nano-meter size efficiently in a short period of time and an InP fine particle dispersion, and there are provided a process for the production of InP fine particles by reacting an In raw material containing two or more In compounds with a P raw material containing at least one P compound in a solvent wherein the process uses, as said two or more In compounds, at least one first In compound having a group that reacts with a functional group of P compound having a P atom adjacent to an In atom to be eliminated with the functional group in the formation of an In-P bond and at least one second In compound having a lower electron density of In atom in the compound than said first In compound and Lewis base solvent as said solvent, and InP fine particles obtained by the process.Type: GrantFiled: March 10, 2006Date of Patent: January 19, 2010Assignee: Hoya CorporationInventor: Shuzo Tokumitsu
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Patent number: 7648690Abstract: Methods of making Si-containing films that contain relatively high levels of substitutional dopants involve chemical vapor deposition using trisilane and a dopant precursor. Extremely high levels of substitutional incorporation may be obtained, including crystalline silicon films that contain 2.4 atomic % or greater substitutional carbon. Substitutionally doped Si-containing films may be selectively deposited onto the crystalline surfaces of mixed substrates by introducing an etchant gas during deposition.Type: GrantFiled: October 2, 2008Date of Patent: January 19, 2010Assignee: ASM America Inc.Inventors: Matthias Bauer, Keith Doran Weeks, Pierre Tomasini, Nyles Cody
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Patent number: 7648691Abstract: A fullerene mixture comprising any two or more of C60, C70 and higher fullerenes having greater than 70 carbon atoms is brought into contact with an amine having two or more nitrogen atoms, especially an amine having an amidine structure, in a solvent to form a complex of a specific fullerene contained in the fullerene mixture and the amine, and the complex is separated from a solution in which fullerenes not forming the complex are dissolved. Consequently, a method of fullerene separation, by which the specific fullerene is separated from the fullerene mixture with ease and at low cost, and the complex having the fullerene can be provided.Type: GrantFiled: August 10, 2004Date of Patent: January 19, 2010Assignee: Frontier Carbon CorporationInventor: Koichi Nagata
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Patent number: 7648692Abstract: Carbonyl sulfide (COS) from a COS-containing stream (106) is convened in a Claus plant (100) to elemental sulfur (152, 162) by oxidation of a first portion of the COS-containing stream to SO2 and by hydrolysis of a second portion of the COS-containing stream to H2S. In preferred aspects of the inventive subject matter, hydrolysis and/or oxidation of the COS is performed in the reactor furnace (10), while hydrolysis of the COS is performed in the reactor furnace (10), a hydrolysis reactor, and/or a catalytic converter (120, 130, 150).Type: GrantFiled: April 22, 2004Date of Patent: January 19, 2010Assignee: Fluor Technologies CorporationInventors: Thomas King Chow, John Gebur, Satish Reddy, Vincent Wai Wong
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Patent number: 7648693Abstract: The present invention provides a powderous lithium transition metal oxide with the composition as represented by the below Formula and prepared by solid state reaction in air from a mixed transition metal precursor and Li2CO3, with being practically free of Li2CO3 impurity: LixMyO2 wherein M=M?1?kAk, where M?=Ni1?a?b(Ni1/2Mn1/2)aCob on condition of 0.65?a+b?0.85 and 0.1?b?0.4; A is a dopant; and 0?k?0.05; and x+y=2 on condition of 0.95?x?1.05. The Ni-based lithium transition metal oxide according to the present invention has a well-layered structure, and also improved safety, cycling stability and stability against aging and low gas evolution during storage, when used as an active material for cathode of lithium secondary batteries, because it has a high sintering stability and is substantially free of soluble bases.Type: GrantFiled: April 13, 2005Date of Patent: January 19, 2010Assignee: LG Chem, Ltd.Inventors: Jens M Paulsen, Hong-Kyu Park, Yong Hoon Kwon
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Patent number: 7648694Abstract: The present invention is directed to a process for preparing zeolites belonging to the SSZ-26/33 family of zeolites using novel nitrogen-based structure directing agents. The process for preparing the SSZ-26/33 family of zeolites involves using a structure directing agent selected from the group consisting of 1,5-bis(N,N-dimethylcyclohexylammonium)pentane dications, 1,4-bis(N-cyclohexylpiperidinium)butane dications and 1,4-bis(N-cyclopentylpiperidinium)butane dications.Type: GrantFiled: October 10, 2008Date of Patent: January 19, 2010Assignee: Chevron U.S.A. Inc.Inventor: Allen W. Burton, Jr.
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Patent number: 7648695Abstract: New chemotherapeutic medicaments and certain medical uses and methods for use of such chemotherapeutic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. Preferably, the halogenated xanthene is Rose Bengal or a functional derivative of Rose Bengal. The halogenated xanthenes constitute a family of useful chemotherapeutic agents that afford selective, persistent accumulation in certain tissues.Type: GrantFiled: July 6, 2001Date of Patent: January 19, 2010Assignee: Provectus Pharmatech, Inc.Inventors: H. Craig Dees, Timothy C. Scott
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Patent number: 7648696Abstract: A stable composition for rapid delivery by inhalation to the lungs, and subsequently to the bloodstream, is provided. The composition comprises a therapeutically effective amount of delta-9-tetrahydrocannabinol in a pharmaceutically-acceptable semiaqueous solvent comprising an alcohol, water and a glycol. A composition comprising volumetric ratios of ethanol:water:propylene glycol selected from those in the range of from 10-70:10-30:20-80, respectively, having a combined total of 100 is also provided. A sterile and/or preserved sealed unit-or multi-unit dosage form of delta-9-tetrahydrocannabinol is further provided.Type: GrantFiled: September 5, 2003Date of Patent: January 19, 2010Assignee: Unimed Pharmaceuticals, LLCInventors: Andrea M McPhillips, Julia J Economou, Mahendra G Dedhiya, Beverly Ann Wynne
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Patent number: 7648697Abstract: Polymers containing one or more of a photostabilizing moiety attached to the polymer backbone, sunscreen compositions including a mixture of a photoactive compound and a polymer containing one or more of a photostabilizing moiety attached to the polymer backbone are described herein. Also disclosed are methods for stabilizing a sunscreen composition and methods of filtering out ultra-violet light from a substrate by the addition of one or more of the foregoing polymers, and methods of waterproofing and forming a film with one or more of the foregoing polymer are described herein.Type: GrantFiled: October 15, 2004Date of Patent: January 19, 2010Assignee: Hallstar Innovations Corp.Inventors: Craig A. Bonda, Anna B. Pavlovic
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Patent number: 7648698Abstract: The present invention relates to a novel vaccine, its use for immunoprophylaxis and/or the treatment of candidamycoses in human and veterinary medicine as well as methods for its preparation, wherein said vaccine consists of the combination of the Candida strains a1) Candida albicans CCM 8355 a2) Candida glabrata CCM 8356 a3) Candida krusei CCM 8357 and a4) an immunomudulating Propionibacterium acnes strain, and optionally pharmaceutically acceptable excipients, such as carriers, wherein the ratio of the components a1-a4 in the end product is a1:a2:a3:a4 is 10-20:10-20:10-20:40-70.Type: GrantFiled: September 23, 2005Date of Patent: January 19, 2010Assignee: Bioveta AGInventors: Dagmar Braun, Vladimir Vrzal, Libor Bittner, Dagmar Koukalova
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Patent number: 7648699Abstract: This invention is directed toward a process for reducing transfusion related complications in a recipient of an allogeneic blood transfusion by adding to the blood to be transfused a photosensitizer comprising riboflavin, irradiating the blood and riboflavin with light, transfusing the irradiated blood into a recipient, and reducing a transfusion related complication by the recipient to cells in the donor blood. The invention is also directed towards a process for preventing rejection of a donor organ by a recipient comprising the steps of transfusing the recipient of the donor organ with treated platelets; and transplanting the donor organ into the recipient.Type: GrantFiled: August 31, 2006Date of Patent: January 19, 2010Assignee: CaridianBCT Biotechnologies, LLCInventors: Raymond P. Goodrich, Junzhi Li
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Patent number: 7648700Abstract: A method of inducing bone formation in a subject in need of such inducement comprises the steps of mechanically inducing an increase in osteoblast activity in the subject and elevating blood concentration of at least one bone anabolic agent in the subject. The method steps may be performed in any order, but in sufficient time proximity that the elevated concentration of the anabolic agent and the mechanically induced increase in osteoblast activity overlaps. The method may additionally comprise providing the subject with an elevated blood concentration of at least one antiresorptive agent, wherein the elevated concentration is sufficient to prevent resorption of new bone growth produced due to the osteoblast activity. Use of the method permits targeting of specific bones of the subject for bone production and preservation, faster bone production and earlier discontinuation of bone anabolic pharmaceuticals. Kits adapted for performing the method are provided.Type: GrantFiled: August 16, 2007Date of Patent: January 19, 2010Assignees: Unigene Laboratories, Inc., Yale UniversityInventors: Agnes Vignery, Nozer M. Mehta, James P. Gilligan
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Patent number: 7648701Abstract: The invention provides peptides comprising a sequence homologous to a portion of the third constant domain of the epsilon heavy chain of IgE, covalently linked to either (1) a carrier protein, or (2) a helper T cell epitope, and optionally to other immunostimulatory sequences as well. The invention provides for the use of such peptides as immunogens to elicit the production in mammals of high titer polyclonal antibodies, which are specific to a target effector site on the epsilon heavy chain of IgE. The peptides are expected to be useful in pharmaceutical compositions, to provide an immunotherapy for IgE-mediated allergic diseases.Type: GrantFiled: November 24, 2003Date of Patent: January 19, 2010Assignee: United Biomedical, Inc.Inventors: Chang Yi Wang, Alan M. Walfield
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Patent number: 7648702Abstract: The present invention relates to an aqueous pharmaceutical composition suitable for long-term storage of polypeptides containing an Fc domain of an immunoglobulin, methods of manufacture, methods of administration and kits containing same.Type: GrantFiled: April 6, 2007Date of Patent: January 19, 2010Assignee: Immunex CorporationInventors: Wayne R. Gombotz, Richard L. Remmele, Jr.
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Patent number: 7648703Abstract: A combination of an anti-Ep-CAM antibody with a chemotherapeutic agent that is capable of arresting Ep-CAM antigen expressing cells in S or G2/M.Type: GrantFiled: January 13, 2005Date of Patent: January 19, 2010Assignee: GlaxoSmithKline LLCInventors: Vincent C. Knick, Julie Beth Stimmel, Linda M. Thurmond
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Patent number: 7648704Abstract: New methods for diagnosis of human dormancy syndrome are provided. Human dormancy syndrome is characterized by elevated serum ratio of rT3/fT3 compared to a population of normal subjects from which subjects suffering from fibromyalgia, chronic fatigue, obesity, dementias including Alzheimer's Disease and related dormancy conditions are excluded, and the presence of one or more findings related to reduced activity including torpor, chronic fatigue, insulin resistance, dementias, obesity and the like. Treatment of human dormancy syndrome is directed toward increasing fT3 levels or decreasing rT3 levels, or both, using pharmaceutical and/or behavioral methods. Other conditions that are associated with HDS can also be treated using T3 therapy, with or without specific psychological, behavioral or pharmaceutical therapies.Type: GrantFiled: October 18, 2007Date of Patent: January 19, 2010Inventor: Michael Powell
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Patent number: 7648705Abstract: The present invention provides a safe and effective vaccine composition against West Nile virus disease. An immunogenically active component of West Nile virus or plasmid DNA, an adjuvant such as a metabolizable oil, and a pharmacologically acceptable carrier are formulated into an immunizing vaccine. The invention also provides a method for the prevention or amelioration of West Nile disease, such as encephalitis, in equidae by administering the vaccine composition herein set forth.Type: GrantFiled: October 30, 2006Date of Patent: January 19, 2010Assignee: Wyeth LLCInventor: Hsien-Jue Chu
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Patent number: 7648706Abstract: The present invention provides a safe and effective vaccine composition against West Nile virus disease. An immunogenically active component of West Nile virus or plasmid DNA, an adjuvant such as a metabolizable oil, and a pharmacologically acceptable carrier are formulated into an immunizing vaccine. The invention also provides a method for the prevention or amelioration of West Nile disease, such as encephalitis, in equidae by administering the vaccine composition herein set forth.Type: GrantFiled: October 30, 2006Date of Patent: January 19, 2010Assignee: Wyeth LLCInventor: Hsien-Jue Chu
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Patent number: 7648707Abstract: The present invention relates to methods and compositions for treatment of microbial infections and for the enhancement of resistance to infection. The invention comprises administration of an effective amount of bacterial lysate compositions for the treatment of pathological conditions of microbial infections. The present invention can also be used to enhance the immune system to prevent infections by the administration of an effective amount of the compositions.Type: GrantFiled: February 11, 2008Date of Patent: January 19, 2010Assignee: Immunology Laboratories, Inc.Inventors: Jiri Pillich, John C. Balcarek
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Patent number: 7648708Abstract: Protein antigens from Streptococcus pneumoniae are disclosed, together with nucleic acid sequences encoding them. Their use in vaccines and in screening methods is also described.Type: GrantFiled: April 18, 2007Date of Patent: January 19, 2010Assignee: Sanofi Pastuer LimitedInventors: Christophe Francois Guy Gilbert, Philip Michael Hansbro
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Patent number: 7648709Abstract: The present invention relates to the field of Immunology, specifically with the branch of Immuno-Allergy and in particular with the use of adjuvant or carrier compounds, capable of modulating the immune response to allergens. The technical objective that is pursued is to obtain a pharmaceutical preparation of therapeutic or prophylactic use using bacterial proteoliposomes, which transform the allergic response Th2 and IgE when being applied in allergic individuals, toward a protector response Th1; as well as it is able to prevent the appearance and the development of allergies in individuals non-allergic yet. The vaccine composition consists of proteoliposomes derived from Gram-negative bacteria coupled to allergens and optionally contains other adjuvants or antigens. The method for its preparation and an immunization scheme of two doses are provided.Type: GrantFiled: May 8, 2003Date of Patent: January 19, 2010Inventors: Miriam de San Juan Bosco Lastre González, Oliver Germán Pérez Martín, Alexis Labrada Rosado, Igor Bidot Martínez, Gustavo Rafael Bracho Granado, Judith Mónica Del Campo Alonso, Dainerys Aleida Pérez Lastre, Elisa Facenda Ramos, Caridad Zayas Vignier, Claudio Rodríguez Martínez, Victoriano Gustavo Sierra González, Jorge Ernesto Pérez Lastre
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Patent number: 7648710Abstract: There is provided an emulsion composition for therapeutic administration comprising: (a) at least one mono-electron transfer agent phosphate derivative; (b) at leas tone di-electron transfer agent phosphate derivative; wherein the amount of mono-electron transfer agent phosphate derivatives is no less than equimolar to the amount of di-electron transfer agent phosphate; and (c) a suitable carrier.Type: GrantFiled: November 14, 2001Date of Patent: January 19, 2010Assignee: Vital Health Sciences Pty Ltd.Inventor: Simon Michael West
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Patent number: 7648711Abstract: A sustained release formulation by using dimeticone as the dispersion medium, which includes active ingredient (e.g., drugs against parasites, insecticides, NSAIDs, antibiotics, sex hormone like agents or oily soluble vitamins) and dimeticone as the medium. Suitable stabilizer, antioxidant, local analgesics and material for sustained release may be added. The formulation is bio-compatible, stable and injectable.Type: GrantFiled: October 8, 2003Date of Patent: January 19, 2010Inventors: Yuwan Wang, Zhende Pan, Xiaoxi Dai
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Patent number: 7648712Abstract: Physiologically acceptable films, including edible films, are disclosed. The films include a water soluble film-forming polymer, such as pullulan, and a taste masked pharmaceutically active agent, such as dextromethorphan. The taste masking agent is preferably a sulfonated polymer ion exchange resin comprising polystyrene cross-linked with divinylbenzene, such as AMBERLITE. Methods for producing the films are also disclosed.Type: GrantFiled: May 5, 2006Date of Patent: January 19, 2010Assignee: McNeil-PPC, Inc.Inventors: William S. Bess, Neema Kulkarni, Suhas H. Ambike, Michael P. Ramsay
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Patent number: 7648713Abstract: Pharmaceutically acceptable hydrogel polymers of natural, recombinant or synthetic origin, or hybrids thereof, are introduced in a dry, less hydrated, or substantially deswollen state and rehydrate in a physiological environment to undergo a volumetric expansion and to affect sealing, plugging, or augmentation of tissue, defects in tissue, or of organs. The hydrogel polymers may deliver therapeutic entities by controlled release at the site. Methods to form useful devices from such polymers, and to implant the devices are provided.Type: GrantFiled: July 9, 2003Date of Patent: January 19, 2010Assignee: Incept LLCInventor: Amarpreet S. Sawhney
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Patent number: 7648714Abstract: This invention relates to a food containing a glycosylated ceramide and diacylglycerol. This food is capable of improving and enhancing the barrier function of skin and increasing water holding capacity of the skin.Type: GrantFiled: August 2, 2005Date of Patent: January 19, 2010Assignee: Kao CorporationInventors: Junko Ishikawa, Yutaka Takagi, Tomoko Nomura
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Patent number: 7648715Abstract: Polymeric particles comprising a polymeric matrix and colourant distributed throughout the matrix, wherein the polymeric matrix that has been formed from a blend of monomers comprising a first monomer which is an ethylenically unsaturated ionic monomer and a second monomer which is an ethylenically unsaturated hydrophobic monomer which is capable of forming a homopolymer of glass transition temperature in excess of 50° C., and in which the first monomer is a salt of a volatile counterion component, characterized in that the polymeric matrix is impermeable to the colourant The particles obtainable by the process of the invention can be used in a variety of industrial processes, for instance in the manufacture of inks, paper and cosmetics.Type: GrantFiled: April 19, 2002Date of Patent: January 19, 2010Assignee: Ciba Specialty Chemicals Water Treatments Ltd.Inventors: Kishor Kumar Mistry, Kenneth Charles Symes, Janine Andrea Preston
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Patent number: 7648716Abstract: An anti-microbial composition for providing a therapeutic application onto a living being. The composition includes from about 0.001 wt. % to about 0.20 wt. % chlorite compound and from about 0.001 wt. % to about 0.05 wt. % peroxy compound. The anti-microbial composition of the present invention is composed to remain intact without being degraded to generate chlorine dioxide during storage at about a room temperature. The anti-microbial composition of the present invention is at a pH range between about 6.0 and about 8.8.Type: GrantFiled: January 26, 2006Date of Patent: January 19, 2010Assignee: SK PharmaceuticalInventor: Hampar J. Karagoezian
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Patent number: 7648717Abstract: The invention relates to the herbal extract having anti-viral activity. More specifically, it relates to the herbal extract produced by extracting the comminuted Fructus Ligustri Lucidi (privet fruit), Rhizoma Polygonati (sealwort), Herba Agrimoniae (agrimonia), Radix Rehmanniae Glutinosae Conquitae (steamed glutinous rehmannia) or the mixture thereof, with a low polar solvent, and to the method for in vitro antagonizing virus by contacting the herbal extract with viruses.Type: GrantFiled: July 29, 2008Date of Patent: January 19, 2010Assignee: Industrial Technology Research InstituteInventors: Li-Ching Lo, Lien-Tai Chen
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Patent number: 7648718Abstract: The present invention relates to a composition comprising an extract of crude drug complex comprising Panax ginseng C. A. Meyer, Acanthopanax senticosus HARMS, Angelica sinensis DIELS, Scutellaria baicalensis GEORGI, prevention and treatment of stroke and neurodegenerative diseases such apoplexy, Alzheimer's disease (AD), Parkinson's disease (PD), Pick's disease, Creutzfeldt-Jakob disease and senile dementia.Type: GrantFiled: January 25, 2005Date of Patent: January 19, 2010Assignee: University-Industry Cooperation Group of Kyung Hee UniversityInventors: Hocheol Kim, Young Min Boo
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Patent number: 7648719Abstract: Method for oxygen treatment of liquid unsaturated carbon compounds with carbon number between 6 and 26 wherein the material is placed in a reaction chamber (11), a mixture ozone and oxygen is passed through the material, and by controlling the flow rate of the gas mixture through the material the temperature of the reaction is controlled to remain below a predetermined maximum value being 100° C. As a result of the reaction a novel material is obtained which has an epoxy-structure, has a higher density and smaller viscosity than the starting material, it has excellent burning properties and can be used as a limited rate source of oxygen. The apparatus for carrying of the method comprises an oxygen source, and ozonizer (6), a reaction chamber (11) for containing the liquid starting material, a gas pump (13) for removing the gas from the reaction chamber, and a temperature control system.Type: GrantFiled: December 4, 2002Date of Patent: January 19, 2010Inventors: Andras Bertha, Mihaly Lantos, Peter Kolta, Peter Kolta, legal representative, Gergely Kolta