Abstract: A vaso-occlusive device is introduced in a cavity of a patient's vasculature, such as an aneurysm, after which an external energy source, such as a MRI machine is activated to heat the vaso-occlusive device to assist in forming a thrombus or embolism within the treatment site, to release and/or activate a diagnostic or therapeutic agent carried by the vaso-occlusive device, and/or to fuse together portions of the vaso-occlusive device to help stabilize the device in a three-dimensional shape.

Abstract: In magnetic resonance imaging (MRI), the powerful magnetic fields can interfere with, damage, cause premature failure in, and attract certain non-MR safe instruments. Electromagnetic ally sensitive components are eliminated in favor of MR safe components, such as ceramic piezoelectric components and bi-metallic components. Instruments that previously had to be kept a safe distance away from the main magnet (12), e.g., beyond the 5 Gauss line, while a patient was being scanned are now allowed near the patient without fear of damage to the instrument (40) or danger to the patient and medical staff or the MRI device (10).

Abstract: A biopsy site marker is disclosed. The biopsy site marker includes a first marker element and a second marker element. The first marker element is configured for detection by a first imaging modality. The second marker element is configured for detection by a second imaging modality different from the first imaging modality. The second marker element may be a non-absorbable wire having a predetermined shape and is substantially engaged with the first marker element.

Abstract: An implantable medical device system includes an implantable device and an external locator device for percutaneously locating detecting port opening of the implantable device. The implantable device includes a port chamber forming the port opening, a septum sealing the port chamber relative to an exterior of the device, and a coil positioned at a known location relative to the port opening. The locator device includes a controller, at least one X-loop electrically coupled to the controller and oriented along a first major axis, and at least one Y-loop electrically coupled to the controller and oriented along a second major axis differing from the first major axis. The system is configured such that when the locator is spatially proximate the coil, an induced voltage in at least the Y-loop(s) is read by the controller to indicate a location of the coil relative to the locator device.

Abstract: System for guiding a catheter through a lumen system of a body of a patient, to a predetermined location within the lumen system, the system including a medical positioning system, a moving mechanism coupled with the catheter, and a controller coupled with the medical positioning system and with the moving mechanism, the medical positioning system including at least one position detector, the position detector being firmly attached to a distal portion of the catheter, the medical positioning system determining the position of the position detector, the controller controlling the operation of the moving mechanism to move the catheter to the predetermined location, according to the position and according to a topological representation of at least a portion of the lumen system.

Abstract: A system for and method of determining and compensating for the effect of a field influencing object on a field sensor, preferably a coil, that is within a navigational domain. The navigational domain contains navigational magnetic energy and disturbing magnetic energy, and the field influencing object produces the disturbing magnetic energy in response to the navigational magnetic energy. The correction system includes a first transmitter for projecting into the navigational domain field energy in a first waveform sufficient to induce a first signal value in the sensing coil. The system also includes a second transmitter for projecting into the navigational domain field energy in a second waveform sufficient to induce a second signal value in the sensing coil. The system further includes a signal processor for receiving the first signal value and for receiving the second signal value to determine the effect of the electrically conductive object on the field sensor.

Abstract: A system for motility contrast imaging a biological target within tissue comprising a CCD array; an illumination source for generating an incoming beam; a first beam splitter for receiving the incoming beam and producing an object beam and a reference beam; a second beam splitter for illuminating a multitude of biological targets with the object beam and for directing backscattered object beams towards the CCD array; a computer-controlled delay stage for zero-path-matching the reference beam to the backscattered object beams; a reference beam that intersects the backscattered object beams at an angle to produce a series of interference fringes that modulate Fourier-domain information; and a computer for receiving a time series of Fourier-domain information. The interference fringes between the backscattered object beam and the reference beam are recorded by the CCD array and passed to the computer which constructs a digital hologram at successive times.

Abstract: A system and method for improving safety in medical procedures where a substance is introduced into a patient is described. An in-vitro diagnostic (IVD) device may be used to measure the concentration of an analyte representing a marker and compare the measured concentration with a predetermined set point so as to determine whether an adverse reaction to the substance may be anticipated. The test data may be obtained at the point-of-service or retrieved from a patient data base. The device for administering the substance is enabled when the comparison of the test data with the predetermined set point indicates that the procedure is expected to be performed with an acceptable risk of an adverse reaction.

Abstract: Provided is a fluorescent indication clip for surgery that has an improved function as a position indicator due to a photo-reactive fluorescent material included in the bio-clip, and allows people to rapidly and easily detect the accurate position of an internal operation region, and thus can improve operation accuracy and reduce side effects caused by excessive incision. The fluorescent indication clip includes a self-spreadable clip body, a fluorescent indicator prepared at the rear end of the clip body and including a photo-reactive fluorescent material, and a clamper configured to slide from a position at which the clamper is mounted on the fluorescent indicator to the clip body by an external force, and fasten the clip body to narrow front ends of the clip body.

Abstract: An embodiment of the invention relates to a process for acquiring a three-dimensional radiological image of an organ in movement of a patient, according to which a control unit executes steps of: (53, 54) receiving a signal representative of a movement parameter of the organ, (53, 54) detecting variation in the signal due to artificial maintenance of the organ in a reduced state of movement, and in response to detection, (59, 510) triggering acquisition of a sequence of images by a radiological imaging device to reconstruct a three-dimensional radiological image of the organ from the sequence of images.

Abstract: The present invention relates to a method of detecting ?-amyloid peptide aggregates in the brain of an individual and kits thereto. The method includes administering to an individual an effective amount of an A?-binding radiopharmaceutical, waiting a period of time, measuring a gamma radiation count over an external area of the head corresponding to the cortex of the individual using a radiation detection device, and comparing the gamma radiation count with a control gamma radiation count.

Abstract: A marker delivery system including a surgical needle defining a lumen. The surgical needle is adapted to receive a marker. The surgical needle includes a side opening substantially adjacent to a first end of the surgical needle. The marker delivery system also includes a plunger insertable into the surgical needle at a second end of the surgical needle. Depression of the plunger inside the lumen of the surgical needle pushes the marker through the side opening of the surgical needle.

Abstract: A power injector (110) is disclosed that operates a drive train (116) in a single, common configuration to operate each of a first syringe (132) and a second syringe (152). That is, no changes need to be made to the drive train (116) to change the discharge from the first syringe (132) to the second syringe (152), or vice versa. In one embodiment, the first plunger (140) of the first syringe (132) is maintained in a stationary position, while its corresponding first syringe barrel or housing (134) is moved, to provide a discharge from the first syringe (132). Conversely for the noted embodiment, the second plunger (160) of the second syringe (152) is moved, while its corresponding second syringe barrel or housing (154) is maintained in a stationary position.

Abstract: At least one embodiment is directed to a sensor for measuring a skeletal system. A signal path of the system comprises an amplifier (612), a sensor element, and an amplifier (620). The sensor element comprises a transducer (4), a waveguide (5), and a reflecting surface (30). An external condition is applied to the sensor element. For example, the sensor element is placed in an artificial orthopedic joint to measure loading of the joint. Pulsed energy waves are emitted by the transducer (4) into the waveguide (5) and the reflected back to be received by the transducer (4). The transit time of each pulsed energy wave corresponds to the external condition applied to the sensor. The transducer (4) outputs a signal corresponding to each pulsed energy wave. A detection circuit edge detects the signal and outputs a pulse to the transducer (4) to generate a new pulse energy wave.

Abstract: A measurement system measures a parameter of a muscular-skeletal system. The measurement system is placed in proximity to the muscular-skeletal system such that the parameter to be measured is applied to a sensing assemblage (3). The measurement system further comprises a digital counter (20), a digital timer (22), a digital clock 24, and a data register (26). The digital counter (20) is preset to a predetermined number of measurement cycles. The digital timer (22) measures an elapsed time of a measurement sequence comprising the predetermined number of measurement cycles. The digital counter (20) is decremented each measurement cycle until a zero count is reached thereby stopping the measurement sequence. The digital timer (22) measures an elapsed time of the measurement sequence. The parameter value can be related to the elapsed time. The precision of a parameter measurement can be modified by changing the predetermined number of measurement cycles.

Abstract: A sensor system uses positive closed-loop feedback to provide energy waves into a medium. It comprises a transducer (604), a propagating structure (602), and a transducer (606). A parameter is applied to the propagating structure that affects the medium. A sensor is coupled to a propagation tuned oscillator (416) that forms a positive closed-loop feedback path. The propagation tuned oscillator (416) includes a zero-crossing receiver (200) that generates a pulse upon sensing a transition of an energy wave from the propagating structure (602). The zero-crossing receiver (200) is in the feedback path that maintains the emission of energy waves into the propagating structure (602). The zero-crossing receiver (200) comprises a preamplifier (206), a filter (208), an offset adjustment circuit (210), a comparator (212) and a pulse circuit (218). The transit time, phase, or frequency is measured of the propagating energy waves and correlated to the parameter being measured.

Abstract: A sensing insert device (100) is disclosed for measuring a parameter of the muscular-skeletal system. The sensing insert device (100) can be temporary or permanent. Used intra-operatively, the sensing insert device (100) comprises an insert dock (202) and a sensing module (200). The sensing module (200) is a self-contained encapsulated measurement device having at least one contacting surface that couples to the muscular-skeletal system. The sensing module (200) comprises one or more sensors (303), electronic circuitry (307), a capacitor (1410), and communication circuitry (320). The capacitor (1410) powers the sensing module during a measurement process. An application specific integrated circuit (ASIC) increases power efficiency while reducing a form factor of the sensing module (200). The ASIC comprises power management circuitry (1412) and operational circuitry (1414).

Abstract: A sensing insert device (100) is disclosed for measuring a parameter of the muscular-skeletal system. The sensing insert device (100) can be temporary or permanent. The sensing module (200) is a self-contained encapsulated measurement device having at least one contacting surface that couples to the muscular-skeletal system. The sensing module (200) comprises one or more sensing assemblages (2302), electronic circuitry (307), an antenna (2302), and communication circuitry (320). The sensing assemblages (2302) are between a top plate (1502) and a bottom plate (1504) in a sensing platform (121). The bottom plate (1504) is supported by a ledge (1708) on an interior surface of a sidewall (1716) of a housing (1706). A cap (1702) couples to top plate (1502). The sensing assemblage (2302) includes one of a piezo-resistive sensor, MEMS sensor, strain gauge, or mechanical sensor when a force, pressure, or load is applied to the top plate (1502).

Abstract: A method and apparatus for obtaining the absolute value of intracranial pressure in a non-invasive manner is described by using an ultrasonic Doppler measuring device which detects the intracranial and extracranial blood flow velocities of the intracranial and extracranial segments of the ophthalmic artery. The eye in which the blood flow is monitored is subjected to an external pressure, sufficient to equalize the intracranial and extracranial angle-independent blood flow factors calculated from the intracranial velocity signal and extracranial velocity signal. The absolute value of the intracranial pressure is identified as that external pressure at which such equalization occurs.

Abstract: A measurement system for capturing a transit time, phase, or frequency of energy waves propagating through a propagation medium is disclosed. The measurement system comprises two different closed-loop feedback paths. The first path includes a transducer driver (726), a transducer (704), a propagation structure (702), a transducer (706), and a zero-crossing receiver (740). The transducer driver (726) efficiently drives the transducer (704) and comprises a digital driver (106), a level shifter (112), and a matching network (114). A second path includes a transducer driver (1126), a transducer (1104), a propagation medium (1102), a reflecting surface (1106), and an edge-detect receiver (1140). Energy waves in the propagating medium (1102) are reflected at least once. The edge-detect receiver (1140) detects a wave front of an energy wave. Each positive closed-loop path maintains the emission, propagation, and detection of energy waves in the propagation medium.

Abstract: A method and related system for providing therapy to a treatment site, such as stenosis or other vasculature disease, at one or more locations of a subject, such as the vasculature. The method includes: advancing an ultrasound catheter to or in proximity to the subject's treatment site; infusing microbubbles into or proximal to the treatment site; and delivering ultrasonic energy from the ultrasound catheter. The ultrasonic energy may be adapted for: imaging the treatment site, translating the microbubbles into or in the vicinity of the treatment site and/or rupturing the microbubbles.

Abstract: A measurement system for capturing a transit time, phase, or frequency of energy waves propagating through a propagation medium is disclosed. The measurement system comprises two different closed-loop feedback paths. The first path includes a driver circuit (628), a transducer (604), a propagation medium (602), a transducer (606), and a zero-crossing receiver (640). The zero-crossing receiver (640) detects transition states of propagated energy waves in the propagation medium including the transition of each energy wave through a mid-point of a symmetrical or cyclical waveform. A second path includes the driver circuit (1228), a transducer (1204), a propagation medium (1202), a reflecting surface (1206), and an edge-detect receiver (1240). Energy waves in the propagating medium (1202) are reflected at least once. The edge-detect receiver (1240) detects a wave front of an energy wave. Each positive closed-loop path maintains the emission, propagation, and detection of energy waves in the propagation medium.

Abstract: Certain embodiments provide an automatic diagnosis support apparatus includes extracting a plurality of parameters associated with a predetermined object by using medical information acquired by a medical image diagnosis apparatus and extracting the plurality of parameters for each disease associated with a disable-bodied person by using medical information associated with the disable-bodied person, calculating a ruler associated with each disease case by executing an MT system using the plurality of parameters for each disease associated with the disable-bodied person, calculating a distance between the object and a state space of the disable-bodied person associated with the each disease by executing the MT system using a plurality of parameters associated with the object, determining a disease type of the object by using the ruler and a distance between the object and a state space of a disable-bodied person, and generating diagnosis support information based on the determination result.

Abstract: In an ultrasound imaging system that applies a beamformer to received ultrasound signal samples to form one or more beams represented by arrays of beamformed samples, a method and an apparatus compress each array of beamformed samples independently of the other arrays to form compressed beams. A plurality of analog to digital converters sample multiple analog ultrasound signals produced by a transducer array to provide multiple streams of ultrasound signal samples to the beamformer. The compressed beams are transferred via a digital interface to a signal processor. At the signal processor, the compressed beams are decompressed to form decompressed beams. The signal processor further processes the decompressed beams for diagnostic imaging, such as for B-mode and Doppler imaging, and scan conversion to prepare the resulting ultrasound image for display. This abstract does not limit the scope of the invention as described in the claims.

Abstract: An elastogram device comprises a driver controller including a wave generator, and an amplifier assembly receiving waves from the wave generator for driving an actuator, the amplifier assembly compatible with at least one pneumatic actuator, at least one hydraulic actuator, at least one piezoelectric actuator, and at least one electromechanical actuator, an elastogram processor receiving a wave image from an imaging source and generating an elastogram from the wave image, and a user input and output assembly including a display rendering the elastogram, a user interface providing a plurality of options for selection, the options including selectable parameters to control the wave generator and to generate the elastogram.

Abstract: Certain embodiments provide an ultrasonic diagnosis apparatus includes acquiring ultrasonic image data corresponding to each time phase in a first interval including at least one contraction and one stretching by scanning a diagnosis region of an object which repeats a contracting motion and a stretching motion, with an ultrasonic wave, accompanying application of a dynamic load including repetitive contraction and relaxation, over the first interval, generating velocity information of the diagnosis region associated with the contracting motion and the stretching motion by using the ultrasonic image data corresponding to each time phase in the first interval, deciding reference information as a reference for a period of the dynamic load by using the velocity information, and generating support information for supporting operation of applying the dynamic load by using the reference period and outputting the information in a predetermined form.

Abstract: In one embodiment, an ultrasonic diagnostic apparatus includes an image creating unit, an image-creation control unit and a display control unit. The image creating unit creates an ultrasound image from data created by adding a reflected wave signal of an ultrasound wave transmitted to an imaging target portion of a subject by using a reception delay time calculated from a set sound velocity set as a sound velocity in the imaging target portion. The image-creation control unit switches a set sound velocity set at a present moment in a variable range, and controls the image creating unit so as to create a plurality of ultrasound images each using a reception delay time corresponding to each of the set sound velocities to be switched. The display control unit controls display such that the ultrasound images created are displayed on a certain display unit.

Abstract: An ultrasound image diagnosis apparatus that can display image data acquired at a plurality of measuring positions in panoramic image data and display measured results of diagnosis parameters for each of the measuring positions of the panoramic image data The panoramic image data is generated by combining a plurality of reference image data generated at a plurality of diagnosis target positions. The plurality of measuring positions is designated based on the latest reference image data composing the panoramic image data. Based on Doppler signals acquired through ultrasound transmissions and receptions to and from the plurality of measurement positions, image data is generated.

Abstract: An ultrasonic diagnostic apparatus that can display various information obtained by acquiring an elasticity image in association with the elasticity image or a biometric simulation image is implemented. The ultrasonic diagnostic apparatus 1 of this invention generates an elasticity image representing hardness or softness of a tissue at a cross-sectional site on the basis of a pair of RF signal frame data which are obtained by transmitting/receiving ultrasonic wave to/from an object 10 and different in acquisition time, and also generates a biometric simulation image 85 simulating the object.

Abstract: A system and method are disclosed that facilitate generating visual representations of characterized tissue based upon ultrasound echo information obtained from a portion of an imaged body. The system includes a first filter having a first filter band that is applied to a near range portion of the ultrasound echo information to render near range filtered echo information. A second filter, having a second filter band that covers a frequency range of the first filter band, is applied to a far range portion of the ultrasound echo information to render far range filtered echo information. The system furthermore includes a set of characterization criteria that are applied to the near and far range filtered echo information. The characterized near and far range image data are thereafter combined into a single tissue-characterization image.

Abstract: The method of accurately measuring the volume of urine in a bladder includes the steps of; generating a plurality of ultrasound scan planes using the received ultrasound signals; detecting distances between the front and back walls of the bladder for each scan line in the ultrasound scan planes; determining an area of the bladder using the detected distances of the scan lines for each ultrasound scan plane; generating a virtual radius of the bladder using the determined area of the bladder for each ultrasound scan plane; determining a calibration coefficient for each ultrasound scan plane using the detected distances of the scan lines; calibrating the virtual radius of the bladder for each ultrasound scan plane using the calibration coefficient; determining the volume of urine in the bladder by calculating the volume of a sphere of which the radius is the average of the calibrated virtual radii for the ultrasound scan planes.

Abstract: An echogenic medical device, such as a needle catheter, which produces an improved ultrasonic image of the device, and a method of performing a medical procedure using a device of the invention. One aspect is directed to a catheter which reduces artifacts in the ultrasound image of the catheter. In one embodiment, the catheter has a spherical distal tip. Another aspect of the invention is directed to an echogenic catheter with echogenic portions arranged in an array to facilitate determination by ultrasonic imaging of the rotational orientation of the catheter relative to a desired location within the patient.

Abstract: An ultrasonic diagnostic apparatus characterized by comprising: an ultrasonic probe for transmitting/receiving an ultrasonic wave to/from an object; a phasing and summing unit for generating RF signal frame data of a cross-sectional site of the object on the basis of a reflection echo signal measured by the ultrasonic probe; an elasticity calculator for generating frame data of elasticity information representing the degree of hardness or softness of a tissue at each measurement point of the cross-sectional site on the basis of a pair of RF signal frame data acquired in different times; a weighting unit for weighting the elasticity information of each measurement point of the generated elasticity frame data in accordance with the degree of sharpness of a distribution of elasticity information for plural measurement points containing adjacent measurement points; a smoothing unit for smoothing the weighted elasticity information of the plurality of elasticity frame data generated at the different times; and an

Abstract: A modular, flexible architecture for offering full-field breast ultrasound (FFBU) functionality and general-purpose ultrasound functionality in a single system is described. A conventional, general-purpose ultrasound system (202) is modified with an FFBU toolkit to create a dual-capability ultrasound system (200), the dual-capability ultrasound system (200) being able to accommodate both general-purpose ultrasound functionality and FFBU functionality, using a single ultrasound engine (112). Among other advantages, real-world clinical environments may enjoy cost savings for initial system procurement, space savings on clinic floors, easier and less expensive system upgrades, and the ability to use a single system and user interface for both FFBU screening and for follow-up diagnosis, biopsy, etc.

Abstract: According to one embodiment, an ultrasonic diagnosis apparatus includes a storage unit, a ultrasonic probe, a transmission/reception unit, a measured value calculation unit, a distance calculation unit, and a determination unit. The storage unit stores data of a state space based on a first measured values of a measurement item associated with an able-bodied person. The transmission/reception unit transmits ultrasonic waves to a subject via an ultrasonic probe, and generates reception signals corresponding to an ultrasonic waves reflected by the subject. The measured value calculation unit calculates a second measured value of the measurement item associated with the subject based on the reception signals. The distance calculation unit calculates a Mahalanobis distance of the subject based on the state space and the second measured value. The determination unit compares the Mahalanobis distance with a threshold to determine whether the subject has the disease evaluated by the measurement item.

Abstract: According to one embodiment, an ultrasonic diagnosis apparatus includes an ultrasonic probe and an ultrasonic scanning unit configured to repeatedly scan an interior of an subject with an ultrasonic wave via the ultrasonic probe and repeatedly acquire echo signals. An image generation unit generates data of blood flow images based on the echo signals. An interpolation processing unit identifies at least one pixel in which clutter components occupy the majority of the pixel value, and to interpolate a pixel value of the identified pixel based on pixel values of at least two other blood flow images corresponding to a substantially same cardiac phase as that of the blood flow image including the identified pixel.

Abstract: According to one embodiment, an ultrasonic probe includes a probe unit and cooling unit. The probe unit is obtained by arranging, in a housing, a transducer unit which transmits and receives ultrasonic waves with an object to be examined, an electronic circuit unit which is connected to the transducer unit and performs electrical signal processing, and a heat transfer member which is made of a material having a heat transfer coefficient higher than that of the electronic circuit unit, and transfers heat of the electronic circuit unit to a housing surface. The cooling unit is detachably mounted on the housing of the probe unit, and cools the heat transfer member by passing a coolant in a channel formed inside the cooling unit.

Abstract: An ultrasound transducer drive circuit includes an output line connected to an ultrasound transducer, a plurality of switching circuits each of which turns on and off a connection of a power supply unit with the output line, a plurality of ground clamp circuits each of which turns on and off a connection of the output line with ground, and a control signal output unit which outputs control signals for turning on and off the switching circuits and the ground clamp circuits. The switching circuits are different in impedance from one another, and the ground clamp circuits are different in impedance from one another.

Abstract: A sensing assemblage (1) for capturing a transit time, phase, or frequency of energy waves propagating through a medium is disclosed to measure a parameter of the muscular-skeletal system. The sensing assemblage (1) comprises a transducer (2) and a waveguide (3). The transducer (2) is coupled to the waveguide (3) at a first location. A second transducer (11) can be coupled to the waveguide (3) at a second location. An interface material that is transmissive to acoustic energy waves can be placed between transducers (402, 404) and a waveguide (414) to improve transfer. The interface material (408, 410) can affix the transducers (402, 404) to the waveguide (414). Alternatively, a reflecting feature (5) can be placed at a second location of the waveguide (3) to reflect acoustic waves back to the transducer (2) where transducer (2) emits energy waves into the medium and detects propagated energy waves.

Abstract: A method for detecting the presence of inhomogeneities in an interior of a turbid medium (1) is provided. The method comprises the steps: performing a first measurement with the turbid medium (1) to be examined placed in a receiving volume (2) of a device for examining the interior of turbid media; performing a second measurement with the turbid medium (1) to be examined placed in the receiving volume (2) of the device for examining the interior of turbid media. The second measurement is performed after a time interval (?t) has passed after the first measurement. Each of the first and second measurements comprises: subsequently irradiating the turbid medium (1) with light from at least one light source (6) from a plurality of different source positions and detecting light emanating from the turbid medium in a plurality of different detection positions for each source position, and storing the detected values as measurement results.

Abstract: An optical analyzer performing analysis excellent in spatial resolution and in invasion depth is provided.

Abstract: A biological information imaging apparatus includes: a light source; an acoustic wave detector that detects an acoustic wave generated from a light absorption material in a living body that has absorbed a part of energy of light irradiated from the light source to the living body, and converts it into a first electric signal; a photodetector that detects optical intensity of a portion of the light irradiated from the light source to the living body and propagating in the living body, and converts it into a second electric signal; and a calculation unit that calculates optical property distribution information on the living body by making use of an analytical result of one of the first electric signal and the second electric signal for analysis of the other electric signal.

Abstract: Methods for monitoring cardiovascular conditions, i.e., hyperdynamic circulation, vasodilation, vasoconstriction, or central-to-peripheral arterial pressure decoupling conditions are described. These methods involve measuring a central signal proportional to or a function of the subject's heart activity and a peripheral signal proportional to or a function of a signal related to the central signal. Then calculating a time difference between features in the central and peripheral signals representing the same heart event. The cardiovascular condition is indicated if the time difference is greater or lower than a threshold value, if the time difference is greater or lower than a threshold value over a specified period of time, or if there is a significant statistical change in the times over the specified time period. These methods can alert a user that a subject is experiencing the cardiovascular condition, which can enable a clinician to appropriately provide treatment to the subject.

Abstract: A blood pressure information measurement device includes a cuff (10A) serving as a detection unit. The cuff (10A) includes an air bladder (40), a photoelectric sensor (50), a belt member (20), and a fixing stand (32), and is attached to a living body by wrapping the belt member (20) around a measuring site. The photoelectric sensor (50) optically detects an intra-arterial volume fluctuation, and includes a light emitting element (51) and a light receiving element (52). The fixing stand (32) includes a base portion (32a) with a sensor attachment surface (32a1) attached with the photoelectric sensor (50), and a guide portion (32b) arranged projecting out from the base portion (32a) toward the sensor attachment surface (32a1) side, and having a distal end placed at a body surface near the measuring site in the attachment state of the cuff (10A).

Abstract: A blood pressure measurement cuff comprising an inflatable bladder, a source of fluidic pressure in fluidic communication with the inflatable bladder, a manometer in fluidic communication with the inflatable bladder, a cover at least partially covering the inflatable bladder and comprising an antimicrobial substance, and means to place the inflatable bladder sufficiently close to a limb of a living being to allow the measurement of the blood pressure of the living being. The source of fluidic pressure can be a pump that transforms human force into fluid pressure, such as a squeezable ball pump, or a canister of compressed fluid. The manometer can include a dial display or a digital display. The cuff can further comprise a tube providing fluidic communication between the manometer and the inflatable bladder, and the tube can be 1 foot or longer. The cover can be made of a fabric coated with an antimicrobial substance.

Abstract: The invention relates to a method and a device for deriving and evaluating cardiovascular information from curves of the cardiac current, in particular for applications in telemedicine. According to the invention, for data reduction purposes, a mean value and a standard deviation across the whole recording time are initially determined from a recorded ECG from the high-resolution signal, after which the RR intervals are assessed by means of an identification algorithm and only the results obtained are transmitted and/or recorded, for the purpose of data reduction.

Abstract: A method of locating a tip of a central venous catheter (“CVC”) having a distal and proximal pair of electrodes disposed within the superior vena cava, right atrium, and/or right ventricle. The method includes obtaining a distal and proximal electrical signal from the distal and proximal pair of electrodes and using those signals to generate a distal and proximal P wave, respectively. A deflection value is determined for each of the P waves. A ratio of the deflection values is then used to determine a location of the tip of the CVC. Optionally, the CVC may include a reference pair of electrodes disposed within the superior vena cava from which a reference deflection value may be obtained. A ratio of one of the other deflection values to the reference deflection value may be used to determine the location of the tip of the CVC.

Abstract: Post-exercise arrhythmias are detected by an implantable medical device. In some aspects, post-exercise arrhythmia may be prognostic of a worsening cardiovascular condition. Thus, the detection of post-exercise arrhythmia may be used as an indicator for adjusting the therapy prescribed for a patient. In some aspects post-exercise arrhythmia are detected if a patient is exercising at a level that equals or exceeds a threshold exercise level. In some aspects, therapy for a patient is modified if the detected post-exercise arrhythmia exceeds a threshold arrhythmia level. In some aspects therapy for a patient is modified if ischemia is detected in conjunction with post-exercise arrhythmia.

Abstract: A heart rate monitor determines a heart rate for a primary subject by reducing noise and cross-talk from unwanted signal transmission sources. A set of pulse peaks having about the same amplitude and an amplitude greater than any other set of peaks are processed to determine a subject's heart rate, while data having an amplitude below that of the set of peaks is ignored. To retrieve enough data to determine a peak amplitude, the signal having heart rate information is sampled at a frequency higher than a normal sampling frequency. In some embodiments, if no data is received for a set time period which is in or above the range, the threshold resets to zero under an assumption that the primary subject is no longer within transmitting range.

Abstract: A method and system for detecting effort events is disclosed. Effort may be determined through feature analysis of the signal as transformed by a continuous wavelet transform, which may be compared against a reference effort measure to trigger an effort event flag that signals the onset and/or severity of an effort event. For example, a respiratory effort measure may be determined based at least in part on a wavelet transform of a photoplethysmograph (PP G) signal and features of the transformed signal. A respiratory reference effort measure may be based at least in part on past values of the respiratory effort measure, and a threshold test may be used to trigger an effort event flag, which may indicate a marked change in respiratory effort exerted by a patient.