Patents Issued in March 12, 2013
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Patent number: 8394885Abstract: The present invention relates to a composition for imparting water repellency to porous mineral substrates and for producing a water repellency effect on the surface of the substrate and to a process for the preparation of such a composition, said composition being based on at least one silane oligomer, at least one hydrolysis or condensation catalyst, at least one fluorine-containing polymer, optionally water and/or at least one organic solvent, optionally at least one emulsifier and optionally further auxiliaries.Type: GrantFiled: June 3, 2009Date of Patent: March 12, 2013Assignee: Evonik Degussa GmbHInventors: Manuel Friedel, Spomenko Ljesic, Sabine Giessler-Blank
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Patent number: 8394886Abstract: Aliphatic unsaturated polyester resins providing excellent weathering resistance. Use of a gelcoat providing excellent weathering resistance, UV resistance, reduction of yellowing and retention of gloss that is especially suitable as gelcoat for exterior glass fiber surfaces such as sailboats, motorboats, yachts and mobile homes. The gel comprises an aliphatic unsaturated polyester resin characterized in having a viscosity of 100-1000 mPa s (25° C.), a monomer content of 40±15% and an acid number of max 15 mg KOH/g.Type: GrantFiled: February 16, 2009Date of Patent: March 12, 2013Assignee: NEW-COAT A/SInventor: Peter Kjær
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Patent number: 8394887Abstract: A fluoropolymer comprising: (A) repeating unit derived from an S-sulfate monomer having an —S—SO3— group and carbon to carbon double bond; and (B) repeating unit derived from a fluoromonomer having a fluorine atom and carbon to carbon double bond. This fluoropolymer can be a constituent of water/oil repellent agent having excellent water/oil repelling capability, and is stable in air and permits an arbitrary control of crosslinking.Type: GrantFiled: April 6, 2006Date of Patent: March 12, 2013Assignee: Daikin Industries, Ltd.Inventors: Kiyoshi Yamauchi, Shinichi Minami, Ikuo Yamamoto
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Patent number: 8394888Abstract: An aqueous dispersion-type acrylic pressure-sensitive adhesive composition includes acrylic copolymer emulsion particles dispersed in an aqueous medium. The acrylic copolymer emulsion particles has a ratio (ANIN)/(ANSUR) of 1 or more, wherein (ANIN) is an amount of acid groups in the acrylic copolymer emulsion particles, and (ANSUR) is an amount of acid groups on the surfaces of the acrylic copolymer emulsion particles, (ANIN) and (ANSUR) being calculated from a titration curve of potentiometric titration performed by adding an inorganic base solution to an acidic sample dispersion solution containing the acrylic copolymer emulsion particles dispersed in ion exchange water. A pressure-sensitive adhesive tape which strongly adheres to an adherend and has excellent removability can be formed using the aqueous dispersion-type acrylic pressure-sensitive adhesive composition.Type: GrantFiled: February 23, 2009Date of Patent: March 12, 2013Assignee: DIC CorporationInventors: Akinori Morino, Naoki Kato
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Patent number: 8394889Abstract: A composition and process for manufacturing a camouflaged aircraft component. The process includes providing an aircraft component; applying an uncured coating onto the aircraft component wherein the uncured coating comprises polysilazane resin, at least one pigment, at least one matting agent, and at least one diluent; allowing the diluent to evaporate; curing the coating to provided a cured coating that comprises cured polysilazane, at least one pigment, and at least one matting agent.Type: GrantFiled: March 22, 2011Date of Patent: March 12, 2013Assignee: Texas Research International Inc.Inventors: John W. Bulluck, Brad A. Rix
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Patent number: 8394890Abstract: Cosmetic composition comprising, as film-forming agent, an aliphatic polyurethane based on dialkyl tartrate diol in a mixture of organic solvents and cosmetically acceptable ingredients.Type: GrantFiled: October 29, 2009Date of Patent: March 12, 2013Assignee: Intercos S.p.A.Inventors: Simona Morlacchi, Anika Salanti
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Patent number: 8394891Abstract: The additive for a polymerizable composition according to the present invention contains a compound represented by the general formula (a). In the general formula (a), R represents a saturated hydrocarbon group having 1 to 3 carbon atoms. M represents Sn, Sb, Bi, or Ge. m represents 0 or 1. R and M are not directly bonded when m is 0. n represents an integer of 1 to 3. X represents a monovalent linking group, and a plurality of X may be the same as or different from each other. When two or more linking groups X are bonded with the metal atom M, the linking groups X may combine together to form a ring.Type: GrantFiled: December 11, 2008Date of Patent: March 12, 2013Assignee: Mitsui Chemicals, Inc.Inventors: Tomoyuki Ando, Seiichi Kobayashi
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Patent number: 8394892Abstract: The present invention provides a thermoplastic elastomer composition comprising: 100 parts by weight of component (A), 10 to 100 parts by weight of component (B), 50 to 200 parts by weight of component (C), and 5 to 30 parts by weight of component (D). Component (A) is a propylene polymer having a melting point of 155° C. or more. Component (B) is a crystalline propylene-ethylene copolymer. Component (C) is an ethylene-?-olefin rubber having Mooney Viscosity of 30 to 100(ML1+4, 125° C.). Component (D) is a hydrogenated product of block copolymer comprising blocks of aromatic vinyl compound units and blocks of conjugated diene compound units.Type: GrantFiled: September 14, 2009Date of Patent: March 12, 2013Assignee: Sumitomo Chemical Company, Ltd.Inventors: Nadeem Akhtar Bokhari, Kousuke Ohtani, Yasuhito Ijichi
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Patent number: 8394893Abstract: The invention relates to a heterophasic alpha-olefÊn random copolymer composition with a melting temperature (Tm) of at least 130° C. and a flexural modulus of not higher than 1000 MPa5 whereby the inventive composition comprises an al-pha-olefin random copolymer component (A) of at least two alpha-olefÊn (co)polymer fractions (i) and (ii) having a different comonomer content, whereby at least one of the fractions is an alpha-olefÊn random copolymer, and a rubber component (B).Type: GrantFiled: January 12, 2006Date of Patent: March 12, 2013Assignee: Borealis Polymers OyInventors: Torwald Vestberg, Bo Malm, Pirjo Jääskeläinen
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Patent number: 8394894Abstract: A conjugated diene polymer is provided that comprises a conjugated diene-based constituent unit and a constituent unit of formula (I) below, at least one terminus of the polymer being modified by a compound having a linkage of formula (II) below. wherein X1, X2, and X3 independently denote a group as defined in the specification.Type: GrantFiled: August 24, 2009Date of Patent: March 12, 2013Assignee: Sumitomo Chemical Company, LimitedInventor: Mayumi Oshima
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Patent number: 8394895Abstract: A process for continuous thermal postcrosslinking of water-absorbing polymer particles, wherein the postcrosslinker is applied to the water-absorbing polymer particles by means of suitable nozzles and the nozzles are exchanged or cleaned via the interior of a glovebox adjoining the plant section comprising the nozzle.Type: GrantFiled: June 10, 2009Date of Patent: March 12, 2013Assignee: BASF SEInventors: Oskar Stephan, Karl J. Possemiers, Ann Becker, Leo Van Miert, Ronny De Kaey
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Patent number: 8394896Abstract: The present invention relates to a liquid ?-olefin vinyl acetate compound containing a liquid ?-olefin vinyl acetate copolymer. Compositions according to the present invention have improved resistance to premature vulcanization as well as good physical properties and aging resistance. The present invention is also directed to a vulcanized compound containing a liquid ethylene vinyl acetate copolymer.Type: GrantFiled: December 6, 2004Date of Patent: March 12, 2013Assignee: Lanxess Inc.Inventors: Richard Pazur, Lorenzo Ferrari
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Patent number: 8394897Abstract: Provided herein are methods for a vinylidene terminated polyolefin comprising: a. ionizing a polyolefin in the presence of a Lewis acid to form an ionized polyolefin; b. reacting the ionized polyolefin from step (a) with one or more dihydrocarbylmonosulfides; and c. reacting the product of step (b) with one or more proton acceptor compounds. In some embodiments, the dihydrocarbylmonosulfide has the formula: R1—S—R2 wherein R1 and R2 are each, independently, hydrocarbyl.Type: GrantFiled: March 25, 2008Date of Patent: March 12, 2013Assignee: Chevron Oronite Company LLCInventor: Casey D. Stokes
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Patent number: 8394898Abstract: Provided herein are methods for preparing a telechelic polymer of formula I wherein R1 is a polyolefin group; R2 and R3 are, independently in each —(CR2R3)— unit, hydrogen or alkyl from 1 to 6 carbons; m is an integer from 2 to 20; RX is a cationic initiator residue; and p is an integer from 1 to 4.Type: GrantFiled: July 31, 2009Date of Patent: March 12, 2013Assignee: The University of Southern MississippiInventors: Robson F. Storey, David L. Morgan
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Patent number: 8394899Abstract: A polyol composition comprising a polyol (a) and resin fine particles (b) dispersed in the polyol (a), and a method for producing the polyol composition are provided, wherein the resin fine particles (b) are particles such that an arithmetic standard deviation by volume of a particle size distribution of the particles, derived from respective values in 85 divisions of a range of 0.020 to 2000 ?m determined by a laser diffraction/scattering particle size distribution analyzer, is not more than 0.6. A resin fine particle-dispersed polyol composition that, even if the resin particles dispersed in the polyol have a small particle diameter, allows the production of a polyurethane resin having an excellent mechanical strength such as elongation at break, and a method for producing the same, are provided.Type: GrantFiled: August 16, 2011Date of Patent: March 12, 2013Assignee: Sanyo Chemical Industries, Ltd.Inventors: Shigekuni Nakada, Hiroyuki Watanabe, Takayuki Tsuji, Hiroki Mori
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Patent number: 8394900Abstract: The present invention generally relates to a method for sequestering carbon dioxide. Biomass is converted into paraffinic hydrocarbons. The paraffinic hydrocarbons are steam cracked into olefins. The olefins are polymerized into non-biodegradable polyolefins.Type: GrantFiled: March 18, 2010Date of Patent: March 12, 2013Assignee: Syntroleum CorporationInventor: Ramin Abhari
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Patent number: 8394901Abstract: An isoprene or butadiene cis 1,4-selective polymerization catalyst system together with its polymerization method is provided. This catalyst system is composed of NCN-imine pincer type rare earth metal complex of formula [2,6-(CH?N—R1)2-4-R2-1-C6H2]LnX2(THF)n and alkylating reagent. In an hydrocarbon solvent or under bulk conditions, at a polymerization temperature in a range of ?20-120° C., the conjugated diene is polymerized by using the catalyst system, to produce polyisoprene and polybutadiene having controllable number-average molecular weight, molecular weight distribution of 3.0 or less than, and cis 1,4-content of 95% or more, even 99% or more. The crude rubber and vulcanized rubber of the polyisoprene have high strength, stretching crystallization capability and transparency.Type: GrantFiled: April 28, 2009Date of Patent: March 12, 2013Assignee: Changchun Institute of Applied Chemistry Chinese Academy of SciencesInventors: Dongmei Cui, Xinli Liu, Dongtao Liu, Wei Gao, Shihui Li, Lingfang Wang, Zhichao Zhang
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Patent number: 8394902Abstract: Pyridyldiamido transition metal complexes are disclosed for use in alkene polymerization.Type: GrantFiled: March 25, 2011Date of Patent: March 12, 2013Assignee: ExxonMobil Chemical Patents Inc.Inventors: John R. Hagadorn, Renuka N. Ganesh, Dmitry V. Uborsky, Ilya S. Borisov, Ivan V. Pruss, Alexander Z. Voskoboynikov
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Patent number: 8394903Abstract: The present invention relates to a novel initiating system for the preparation of a living diene elastomer functionalized at the chain end by an amine group by anionic polymerization. The novel initiating system comprises an organolithium compound and a tin amide. The invention also relates to processes for the preparation of modified elastomers comprising an amine group at the chain end. These modified elastomers prove to be particularly advantageous in reinforced rubber compositions for tyres as they confer improved dynamic and mechanical properties in the vulcanized state.Type: GrantFiled: December 22, 2009Date of Patent: March 12, 2013Assignees: Compagnie Generale des Etablissements Michelin, Michelin Recherche et Technique S.A.Inventor: Jean-Marc Marechal
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Patent number: 8394904Abstract: The invention relates to an improved process for preparing alkoxyamines resulting from ?-phosphorated nitroxides corresponding to the formula (I): by reaction with a halogenated derivative in the presence of an organometallic system. This process comprises carrying out the reaction in a water-miscible organic solvent and precipitating the alkoxyamine directly from the organic medium by adding an aqueous solution of a strong acid. These alkoxyamines can be used in particular as radical polymerizations initiators.Type: GrantFiled: July 8, 2008Date of Patent: March 12, 2013Assignee: Arkema FranceInventor: Jean-Luc Couturier
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Patent number: 8394905Abstract: Disclosed herein is a telechelic diacrylate fluoropolymer and a process for manufacture of the fluoropolymer. The diacrylate copolymer is of formula CH2?CR?COO—(CH2)n—R—(CH2)n—OOCCR??CH2, wherein R is selected from the group consisting of i) an oligomer comprising copolymerized units of vinylidene fluoride and perfluoro(methyl vinyl ether), ii) an oligomer comprising copolymerized units of vinylidene fluoride and hexafluoropropylene, iii) an oligomer comprising copolymerized units of tetrafluoroethylene and perfluoro(methyl vinyl ether), and iv) an oligomer comprising copolymerized units of tetrafluoroethylene and a hydrocarbon olefin, R? is H or —CH3, n is 1-4 and wherein said oligomer has a number average molecular weight of 1000 to 25,000 daltons.Type: GrantFiled: July 16, 2009Date of Patent: March 12, 2013Assignees: E I du Pont de Nemours and Company, Le Centre National de la Recherche ScienceInventors: Ming-Hong Hung, Bruno Ameduri, Georgi Kostov
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Patent number: 8394906Abstract: The invention is a polymeric ophthalmic lens material comprising a polymeric ophthalmic lens material comprising a) one or more lens-forming polymerizable monomers selected from the group of hydrophilic acrylate-substitute monomers, hydrophobic acrylate-substituted monomers, vinyl-substituted monomers, and platinum-catalyzed vinyl hydride addition-cured silicones, b) a polymerizable ultraviolet absorber and c) a polymerizable yellow dye. In one embodiment of the invention, the polymerizable ultraviolet absorber has the formula: and the polymerizable yellow dye has the formula: wherein R1=vinyl, R2, R3=H, alkyl, hydroxyalkyl, wherein R2=vinyl, R1, R3=H, alkyl, hydroxyalkyl, and wherein R3=vinyl, R1, R2=H, alkyl, hydroxyalkyl.Type: GrantFiled: February 11, 2009Date of Patent: March 12, 2013Assignee: Aaren Scientific Inc.Inventor: Marie Dvorak Christ
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Patent number: 8394907Abstract: A polypropylene resin comprising a propylene polymer having the following features: a) melt flow rate (MFR) (ISO 1133) (230° C./2.16 kg) comprised between 120 g/10? and 400 g/10?; b) distribution of molecular weight Mw/Mn lower than 4; c) haze measured according to ASTM D 1003 comprised between 5% and 30%; and d) flexural modulus measured according ISO 178 after 48 h comprised between 1750 N/m2 and 2300 N/m2.Type: GrantFiled: October 12, 2006Date of Patent: March 12, 2013Assignee: Basell Polyolefine GmbHInventors: Alexander Fuchs, Bernd Schuetz
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Patent number: 8394909Abstract: A silane-terminated polyurethane composition is the reaction product of a silane-terminated polyurethane prepolymer component, a silane-terminated monomeric diisocyanate, and optionally at least one multifunctional trisilane or tetrasilane component. A method for making a composition includes (a) providing a silane-terminated polyurethane prepolymer component, a silane-terminated monomeric diisocyanate component, and optionally at least one multifunctional trisilane or tetrasilane component, and (b) combining the prepolymer component, monomeric component, and optional multifunctional silane component to form a silane-terminated polyurethane reaction product with a tensile strength of about 4 MPa or greater and an elongation of about 200% or greater.Type: GrantFiled: December 29, 2008Date of Patent: March 12, 2013Assignee: Construction Research & Technology GmbHInventors: Michael J. Porsch, Kelly A. Kuznia Freudenberg
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Patent number: 8394910Abstract: A method of making a polymeric material is described, the method comprising contacting, for example polycondensing, a compound of formula with a compound of formula wherein each X is selected from a group comprising a chlorine and a fluorine atom, n represents 1, 2 or 3 and each Y1 is selected from a group comprising an alkali metal and a hydrogen atom.Type: GrantFiled: May 26, 2006Date of Patent: March 12, 2013Assignee: Victrex Manufacturing LimitedInventors: Brian Wilson, John Kevin Prescott, Graham Robert Webster
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Patent number: 8394911Abstract: A phenol resin composition used as a curing agent for an epoxy resin includes a naphthol novolac resin (a1) represented by general formula (1) (wherein R1 and R2 each independently represent a hydrogen atom, an alkyl group, or an alkoxy group, and n is a repeating unit and an integer of 1 or more), and a compound (a2) represented by general formula (2) (wherein R1 and R2 each independently represent a hydrogen atom, an alkyl group, or an alkoxy group), wherein the total ratio of compounds with n=1 and n=2 in the general formula (1) present in the composition is in the range of 10 to 35%, the average of n in the general formula (1) is in the range of 3.0 to 7.0, and the content of the compound (a2) in the composition is 1 to 6%.Type: GrantFiled: January 19, 2011Date of Patent: March 12, 2013Assignee: DIC CorporationInventors: Yutaka Satou, Kazuo Arita, Ichirou Ogura
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Patent number: 8394912Abstract: The invention relates to a process for the pretreatment of material surfaces in order to minimize the interaction between polycarbonate and metal and, in the processing and synthesis of polycarbonate, to obtain a high-quality polymer which in particular does not become discolored and is free of insoluble constituents.Type: GrantFiled: December 20, 2010Date of Patent: March 12, 2013Assignee: Bayer MaterialScience AGInventors: Frank Doebert, Andreas Stremmel, Christoph Biedron, Stephan Laue, Johann Rechner, Torsten Hagen, Frank Bruynseels, Frank Quaeyhaegens, Johan Decloedt, Paul Van Dorst, Uwe Arndt, Johan Vanden Eynde, Ursula Tracht, Thomas König, Ulrich Liesenfelder
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Patent number: 8394913Abstract: Method for producing polyphenylene ether, comprising preparing a polymerization solution of 10-25 parts by mass of a phenolic compound (M) and 75-90 parts by mass of an aromatic solvent (A) with the total of the compound and the solvent being 100 parts by mass, and 0.1-10 parts by mass of a catalyst (C) containing a metal salt; performing oxidative polymerization of the phenolic compound (M) by passing oxygen-containing gas through polymerization solution; stopping polymerization by mixing aqueous chelating agent solution into polymerization solution; subjecting a diphenoquinone compound produced as a by-product to quinone binding process or removal by reduction; and obtaining polyphenylene ether by separating aqueous phase through liquid-liquid separation. In the method for producing a polyphenylene ether, 0.001-0.004 part by weight of an ion catalyst (D) is added into the polymerization solution before the liquid-liquid separation.Type: GrantFiled: February 15, 2012Date of Patent: March 12, 2013Assignee: Asahi Kasei Chemicals CorporationInventors: Mutsumi Maeda, Hiroaki Furukawa
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Patent number: 8394914Abstract: Poly(glycolide) polymers are disclosed. The polymers generally include a glycolide-based polymer backbone that includes one or more functional groups such as alkynyl groups, hydrophilic organic triazole groups, hydrophobic organic triazole groups (also including amphiphilic organic triazole groups), di-triazole organic crosslinking groups, and triazole-substituted drug derivatives. The alkynyl groups provide reactive sites for further functionalization of the polymer, for example by reaction with azide derivatives. The polymers can further encapsulate a drug for delivery to a patient (i.e., as compared to drug derivatives that are covalently attached to the polymer). The polymers can be in the form of thermodynamically stable unimolecular micelles or crosslinked nanoparticles. The polymer compositions are completely biodegradable and hold great potential for use in biomedical applications.Type: GrantFiled: July 22, 2009Date of Patent: March 12, 2013Assignee: Board of Trustees of Michigan State UniversityInventors: Gregory L. Baker, Milton R. Smith, III, Erin Vogel
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Patent number: 8394915Abstract: A polyesterification method comprises steps of mixing, by combining N,N-dialkylformamide dialkyl acetal with a tin catalyst, so as to transfer an alkoxy group from the N,N-dialkylformamide dialkyl acetal to the tin catalyst to obtain a Sn coordination complex; and polymerization, by conducting a ring-opening polymerization of a ester under the catalysis of the Sn coordination complex, and finally to obtain a polyester compound; wherein, the chemical formula of the N,N-dialkylformamide dialkyl acetal is (RO)2CHNR2, with the R being an alkyl group.Type: GrantFiled: July 22, 2011Date of Patent: March 12, 2013Assignee: Kaohsiung Medical UniversityInventors: Hsuan-Ying Chen, Hsin-Jou Fang
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Patent number: 8394916Abstract: The present invention is based on a process for oligothiophene synthesis at elevated temperatures and low catalyst concentrations.Type: GrantFiled: August 1, 2008Date of Patent: March 12, 2013Assignee: Bayer Technology Services GmbHInventors: Björn Henninger, Frank Rauscher, Leslaw Mleczko
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Patent number: 8394917Abstract: Embodiments of the invention are directed to alternating donor-acceptor (DA) polymers that are soluble and display a blue or green neutral state that oxidizes to a transmissive state for use as an electrochromic polymer. The D units have 3,4-dioxythiophene, 3,6-dialkoxythieno[3,2-b]thiophene or 3,5-dialkoxy-dithieno[3,2-b:2?,3?-d]thiophene groups. Embodiments of the invention are directed to a method for preparation of the alternating DA polymeric sequences of the DA polymers by a cross-condensation of a nucleophilic acceptor monomer and an electrophilic donor monomer.Type: GrantFiled: July 2, 2010Date of Patent: March 12, 2013Assignee: University of Florida Research Foundation, Inc.Inventors: Chad Martin Amb, Pierre Marc Beaujuge, John R. Reynolds
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Patent number: 8394918Abstract: Compounds having a core comprised of an aromatic ring and at least two annulated beta-substituted fused thiophene ring systems of the general formula: -(?-R2—FT2ArFT2-?-R2)—, and polymers or copolymers thereof, of the general formulas: -{-?-R2—FT2ArFT2-?-R2)-G1-}n-, or -{-G1-(?-R2—FT2ArFT2-?-R2)-G1-G2-}n-, where ?-R2—FT2ArFT2-?-R2, -G1-, -G2-, and n are as defined herein. Also disclosed are compositions, articles, or devices comprising the polymers, and methods for making and using the polymers. The compositions, articles, or devices can be used, for example, for electronic applications, such as light emitting devices and semiconductor devices.Type: GrantFiled: February 28, 2011Date of Patent: March 12, 2013Assignee: Corning IncorporatedInventors: Mingqian He, Thomas Mark Leslie, Weijun Niu, Adama Tandia
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Patent number: 8394919Abstract: The present invention provides a polymer comprising a unit of formula The present invention also provides an electronic device comprising the polymer as semiconducting material.Type: GrantFiled: April 24, 2012Date of Patent: March 12, 2013Assignee: BASF SEInventors: Ashok Kumar Mishra, Subramanian Vaidyanathan, Hiroyoshi Noguchi, Florian Dötz, Yucui Guan
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Patent number: 8394920Abstract: According to a preferable embodiment of the present invention, a composition for a resin comprising an inorganic compound having a sulfur atom and/or a selenium atom, an episulfide compound, and a mercaptodisulfide compound can be provided. According to another preferable embodiment of the present invention, a composition for a resin having the viscosity thereof decreased to facilitate a cast polymerization operation and thus to improve the tonality of the obtained optical material can be provided. According to still another preferable embodiment of the present invention, an optical material obtained by curing the above-described composition for a resin and having a high refractive index can be provided.Type: GrantFiled: February 2, 2009Date of Patent: March 12, 2013Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Motoharu Takeuchi, Takashi Aoki
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Patent number: 8394921Abstract: The present invention relates to methods for producing N-terminal derivatives of proteins in which a polysaccharide, preferably having at least terminal sialic units and preferably consisting essentially only of sialic acid units, is reacted at the N-terminus of a protein or peptide under controlled conditions to produce an N-terminal derivative. The controlled conditions include use of acidic pH for the derivatisation step and a higher pH for purification. The derivatives are useful for improving pharmacokinetics and pharmacodynamics of proteins and peptides.Type: GrantFiled: July 25, 2007Date of Patent: March 12, 2013Assignee: Lipoxen Technologies LimitedInventors: Sanjay Jain, Peter Laing, Gregory Gregoriadis
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Patent number: 8394922Abstract: Antiproliferative compounds having a structure represented by formula (II), where n, R1, R2, R3, R4, and R5 are as defined herein, can be used to treat tumors, optionally when conjugated to a ligand such as an antibody:Type: GrantFiled: July 29, 2010Date of Patent: March 12, 2013Assignee: Medarex, Inc.Inventors: Heng Cheng, Qiang Cong, Sanjeev Gangwar
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Patent number: 8394923Abstract: A simple, efficient apparatus and method for separating layers of immiscible or partially miscible liquids useful in methods of high-throughput combinatorial organic synthesis or parallel extraction of large libraries or megaarrays of organic compounds is disclosed. The apparatus and method are useful, whether as part of an automated, robotic or manual system for combinatorial organic synthesis or purification (extraction). In a preferred embodiment, an apparatus and method for separating layers of immiscible or partially miscible liquids compatible with microtiter plate type array(s) of reaction vessels is disclosed. Another application of centrifugation based liquid removal was found for washing the plates in biological assays or synthesis on modified substrates.Type: GrantFiled: May 11, 2012Date of Patent: March 12, 2013Assignee: Illumina, Inc.Inventor: Michal Lebl
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Patent number: 8394924Abstract: The present invention features engineered proteins that include a first polypeptide that specifically binds a first target (e.g., a cellular target, such as a cell-surface antigen) and a second polypeptide that selectively binds an activating FcR.Type: GrantFiled: October 23, 2009Date of Patent: March 12, 2013Assignee: Massachusetts Institute of TechnologyInventors: K. Dane Wittrup, Shanshan Wu Howland
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Patent number: 8394925Abstract: The present application relates to a variant Fc region comprising the double mutation 428L/434S that increases serum half-life and the numbering is according to the EU index.Type: GrantFiled: December 15, 2011Date of Patent: March 12, 2013Assignee: Xencor, Inc.Inventors: Aaron Keith Chamberlain, Bassil I. Dahiyat, John R. Desjarlais, Sher Bahadur Karki, Gregory Alan Lazar
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Patent number: 8394926Abstract: The present disclosure relates to a bispecific single chain antibody which has a first binding domain specifically binding to human CD3, and a second binding domain specifically binding to human CEA, where the second binding domain comprises at least a part of the CDR-H3 or the complete CDR-H3 of murine monoclonal antibody A5B7, a pharmaceutical composition comprising the bispecific single chain antibody, and methods for the treatment of an epithelial tumor in a human with the pharmaceutical compositions containing the bispecific single chain antibody. Furthermore, processes for the production of the pharmaceutical compositions as well as medical/pharmaceutical uses for the specific bispecific single chain antibody molecules bearing specificities for the human CD3 antigen and the human CEA antigen are disclosed.Type: GrantFiled: December 21, 2006Date of Patent: March 12, 2013Assignee: Micromet AGInventors: Ralf Lutterbüse, Petra Mayer, Evelyne Schaller, Doris Rau, Susanne Mangold, Peter Kufer, Alexander Murr, Tobias Raum, Monika Wissinger
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Patent number: 8394927Abstract: The present invention relates to FGFR4 antibodies including fragments or derivatives thereof and the polynucleotides encoding the antibodies. Expression vectors and host cells comprising the polynucleotides are provided. Further, the invention refers to pharmaceutical compositions comprising the FGFR4 antibodies and methods for the treatment, prevention or diagnosis of disorders associated with FGFR4 expression.Type: GrantFiled: November 2, 2007Date of Patent: March 12, 2013Assignee: U3 Pharma GmbHInventors: Johannes Bange, Jens Niewoehner, Patricia Aus Dem Siepen, Mike Rothe
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Patent number: 8394928Abstract: The present invention relates to humanized antibodies against human CDCP1 (anti-CDCP1 antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.Type: GrantFiled: August 26, 2010Date of Patent: March 12, 2013Assignee: Roche Glycart AGInventors: Johannes Auer, Birgit Bossenmaier, Guy Georges, Alexander Lifke, Ekkehard Moessner, Gerhard Niederfellner
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Patent number: 8394929Abstract: Disclosed are NgR proteins and biologically active Nogo (ligand) protein fragments. Also disclosed are compositions and methods for modulating the expression or activity of the Nogo and NgR protein. Also disclosed are peptides which block Nogo-mediated inhibition of axonal extension. The compositions and methods of the invention are useful in the treatment of cranial or cerebral trauma, spinal cord injury, stroke or a demyelinating disease.Type: GrantFiled: January 26, 2010Date of Patent: March 12, 2013Assignee: Yale UniversityInventor: Stephen M. Strittmatter
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Patent number: 8394930Abstract: An isolated VEGF polypeptide having anti-angiogenic activity, said polypeptide including the amino acid sequence of SEQ.ID NO.1, or variants thereof.Type: GrantFiled: April 27, 2010Date of Patent: March 12, 2013Assignee: University of BristolInventors: David O. Bates, Steven J. Harper
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Patent number: 8394931Abstract: This invention concerns a panel of monoclonal antibodies against the High Mobility Group A 1 protein (HMGA1) and a process for preparing them, as well as the use of said antibodies for the quantitative determination of HMGA1 in biological fluids or in protein Iy sates deriving from lymphocyte cells. This invention also concerns a diagnostic kit for assessing risk factors related to the expression of the HMGA1 proteins.Type: GrantFiled: April 29, 2009Date of Patent: March 12, 2013Assignee: Areta International S.R.L.Inventors: Alfredo Fusco, Antonio Orlandi, Maria Luisa Nolli
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Patent number: 8394932Abstract: The present invention relates to the discovery of the human survival motor-neuron gene or SMD gene, which is a chromosome 5-SMA (Spinal Muscular Atrophy) determining gene. The present invention further relates to the nucleotide sequence encoding the SMN gene and corresponding amino acid sequence, a vector containing the gene encoding the SMN protein or a DNA sequence corresponding to the gene and transformant strains containing the SMN gene or a DNA sequence corresponding to the gene.Type: GrantFiled: April 28, 2011Date of Patent: March 12, 2013Assignee: Institut National de la Sante et de la Recherche MedicaleInventors: Judith Melki, Arnold Munnich
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Patent number: 8394933Abstract: It is an object of the present invention to provide: a protein refolding column filler, which is effective for the refolding, namely, the activation of the function, of an inactive protein with an as yet unformed higher order structure produced in Escherichia coli or the like, or a protein whose conformation has been changed due to a certain cause and which has become inactivated; and a column filled with the aforementioned column filler. The present invention provides a protein refolding column filler, which comprises zeolite with BEA structure (Zeolite Beta) that is granulated into a particle state.Type: GrantFiled: April 4, 2008Date of Patent: March 12, 2013Assignee: FUJIFILM CorporationInventors: Masayuki Kawakami, Tatsuo Tsunoda, Hideaki Togashi, Takayuki Nara, Shun-ichi Matsuura, Chisato Sekikawa, Akiko Kawai, Akiyoshi Kawata, Fujio Mizukami, Kengo Sakaguchi
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Patent number: 8394934Abstract: A method is disclosed for synthesizing 2?,3?-didehydro-2?,3?-dideoxynucleosides (d4Ns) from a nucleophile-mediated elimination, such as a telluride-mediated elimination reaction. After substitution of 2,2?-anhydronucleosides with a nucleophile, such as a telluride monoanion, a telluride intermediate is formed, and its elimination leads to formation of the olefin products (d4Ns). This disclosure describes this telluride-assisted (or nucleophile-assisted) reaction and how to facilitate the substitution and elimination in order to form d4Ns.Type: GrantFiled: March 20, 2009Date of Patent: March 12, 2013Inventors: Zhen Huang, Jia Sheng
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Patent number: 8394935Abstract: An object of the present invention is to provide a industrially appropriate method for producing the ?-anomers of ribofuranose derivatives in a highly selective manner at a high yield. The present invention provides a method for producing ribofuranose derivatives wherein ?-anomers is precipitated from among the generated furanose derivatives by controlling the amount of a reaction reagent used and/or using a poor solvent in the acetolysis reactions of 2,3,5-tri-O-acyl-1-O-alkyl-ribofuranose and 2,3-di-O-acyl-1-O-alkyl-5-deoxy-ribofuranose.Type: GrantFiled: December 7, 2007Date of Patent: March 12, 2013Assignee: API CorporationInventors: Manabu Katsurada, Tomoko Sasaki, Yasuko Nakajima, Nobuo Kyoumura