Patents Issued in April 9, 2013
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Patent number: 8415257Abstract: Amorphous carbon material may be deposited with superior adhesion on dielectric materials, such as TEOS based silicon oxide materials, in complex semiconductor devices by applying a plasma treatment, such as an argon treatment and/or forming a thin adhesion layer based on silicon dioxide, carbon-doped silicon dioxide, prior to depositing the carbon material. Consequently, the hard mask concept based on amorphous carbon may be applied with an increased degree of flexibility, since a superior adhesion may allow a higher degree of flexibility in selecting appropriate deposition parameters for the carbon material.Type: GrantFiled: October 6, 2010Date of Patent: April 9, 2013Assignee: GLOBALFOUNDRIES Inc.Inventors: Hartmut Ruelke, Volker Jaschke
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Patent number: 8415258Abstract: Provided is a method of manufacturing a semiconductor device. The method includes: loading a substrate into a process vessel; performing a process to form an film on the substrate by alternately repeating: (a) forming a layer containing an element on the substrate by supplying at least two types of source gases into the process vessel, each of the at least two types of source gases containing the element, and (b) changing the layer containing the element by supplying reaction gas into the process vessel, the reaction gas being different from the at least two types of source gases; and unloading the processed substrate from the process vessel.Type: GrantFiled: November 1, 2011Date of Patent: April 9, 2013Assignee: Hitachi Kokusai Electric Inc.Inventors: Naonori Akae, Yoshiro Hirose, Yushin Takasawa, Yosuke Ota, Ryota Sasajima
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Patent number: 8415259Abstract: A method of forming a film on a semiconductor substrate by plasma enhanced atomic layer deposition (PEALD), includes: introducing a nitrogen- and hydrogen-containing reactive gas and a rare gas into a reaction space inside which the semiconductor substrate is placed; introducing a precursor in pulses of less than 1.0-second duration into the reaction space wherein the reactive gas and the rare gas are introduced; exiting a plasma in pulses of less than 1.0-second duration immediately after the precursor is shut off; and maintaining the reactive gas and the rare gas as a purge of less than 2.0-second duration.Type: GrantFiled: March 2, 2012Date of Patent: April 9, 2013Assignee: ASM Japan K.K.Inventors: Woo Jin Lee, Kuo-Wei Hong, Akira Shimizu, Daekyun Jeong
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Patent number: 8415260Abstract: A chip identification for organic laminate packaging and methods of manufacture is provided. The method includes forming a material on a wafer which comprises a plurality of chips. The method further includes modifying the material to provide a unique identification for each of the plurality of chips on the wafer. The organic laminate structure includes a chip with a device and a material placed on the chip which is modified to have a unique identification mark for the chip.Type: GrantFiled: April 8, 2010Date of Patent: April 9, 2013Assignee: International Business Machines CorporationInventors: Albert J. Banach, Timothy H. Daubenspeck, Wolfgang Sauter
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Patent number: 8415261Abstract: Methods of forming a capping layer on conductive lines in a semiconductor device may be characterized by the following operations: (a) providing a semiconductor substrate comprising a dielectric layer having (i) exposed conductive lines (e.g., copper lines) disposed therein, and (ii) an exposed barrier layer disposed thereon; and (b) depositing a capping layer material on at least the exposed conductive lines of the semiconductor substrate. In certain embodiments, the method may also involve removing at least a portion of a conductive layer (e.g., overburden) disposed over the barrier layer and conductive lines to expose the barrier layer.Type: GrantFiled: October 11, 2011Date of Patent: April 9, 2013Assignee: Novellus Systems, Inc.Inventors: Jonathan D. Reid, Eric G. Webb, Edmund B. Minshall, Avishai Kepten, R. Marshall Stowell, Steven T. Mayer
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Patent number: 8415262Abstract: Porous fibrous sheets are provided that are useful in end uses requiring microbial barrier properties such as medical packaging and medical gowns and drapes. The porous fibrous sheets may contain nanofibers and wood pulp.Type: GrantFiled: October 22, 2004Date of Patent: April 9, 2013Assignee: E I du Pont de Nemours and CompanyInventors: Ioannis V. Bletsos, Joseph Robert Guckert, Mikhail R. Levit, David Carl Roberts
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Patent number: 8415263Abstract: A composite material as a sheet material is described, being relatively cheap, most useful as a raw material of a sanitary product or the like, such as underwear, dust-proof mask or dispensable paper diaper, etc., and good in processability, stretchability, gas-permeability, softness, and touch. The composite material is formed by laminating a stretchable layer and a conjugate spunbonded nonwoven fabric including conjugate fibers including a low-melting-point component and a high-melting-point component. The conjugate fibers are partially bonded to each other by thermocompression, wherein each bonded portion has fine folded structures including alternate hill and valley regions in the CD, and the distance between neighboring hills is 100-400 ?m in average. The conjugate spunbonded nonwoven fabric exhibits stretchability through the spread of the fine folded structures, and has, at 5% elongation, a CD-strength of 0.1 N/5 cm or less and an MD/CD strength ratio of 200 or more.Type: GrantFiled: March 30, 2011Date of Patent: April 9, 2013Assignees: JNC Corporation, JNC Fibers CorporationInventors: Toshikatsu Fujiwara, Taiju Terakawa
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Patent number: 8415264Abstract: One exemplary embodiment can be a process for regenerating catalyst in a fluid catalytic cracking unit. Generally, the process includes providing a feed to a riser of a reaction vessel, and providing a stream to a distributor positioned within a void proximate to an inlet receiving unregenerated catalyst in a regenerator. The feed can include at least one of a gas oil, a vacuum gas oil, an atmospheric gas oil, a coker gas oil, a hydrotreated gas oil, a hydrocracker unconverted oil, and an atmospheric residue.Type: GrantFiled: April 30, 2010Date of Patent: April 9, 2013Assignee: UOP LLCInventors: Daniel N. Myers, Paolo Palmas, David Nathan Myers
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Patent number: 8415265Abstract: A process for the preparation of melamine by decomposition of urea with the use of a catalyst, the catalyst comprising a) 10-90% by weight of zeolite, b) 10-90% by weight of a matrix comprising silica, alumina, silicon aluminum oxides and/or clay minerals, and c) 0-10% by weight of additives and the total content of nickel and vanadium in the catalyst being less than 500 ppm.Type: GrantFiled: May 21, 2008Date of Patent: April 9, 2013Assignee: BASF SEInventors: Christian Kuhrs, Andreas Kern, Tilo John, Wolfgang Steiner, Heiko Maas
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Patent number: 8415266Abstract: The invention relates to catalyst components, containing: (A) at least one Brönsted acid, (B) water, (C) at least one antacid-acting compound from the group consisting of the oxides, hydroxides, carbonates and/or carboxylates of the elements aluminum, chromium, copper, germanium, manganese, lead, antimony, tin, tellurium, titanium and/or zinc, (D) optionally at least one inert diluent, (E) optionally at least one modifier, the mixture of one part by weight of the catalyst component with three parts by weight bisaziridino polyether with an average imino equivalent mass of 3100, preparable from a polyetherdiol which comprises ethylene oxide and tetrahydrofuran units in the molar ratio 1:3.5 solidifying within 0.5 to 20 minutes to a solid elastomer material which has a shore A hardness of at least 20 according to DIN 53505 after 24 hours' storage time at room temperature.Type: GrantFiled: April 12, 2001Date of Patent: April 9, 2013Assignee: 3M Deutschland GmbHInventors: Gunther Eckhardt, Erich Wanek, Bernd Kuppermann
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Patent number: 8415267Abstract: Core-shell nanoparticles having a core material and a mesoporous silica shell, and a method for manufacturing the core-shell nanoparticles are provided.Type: GrantFiled: June 4, 2012Date of Patent: April 9, 2013Assignee: Korea University Research and Business FoundationInventor: Kwangyeol Lee
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Patent number: 8415268Abstract: A process for producing a ringlike oxidic shaped body by mechanically compacting a pulverulent aggregate introduced into the fill chamber of a die, wherein the outer face of the resulting compact corresponds to that of a frustocone.Type: GrantFiled: June 30, 2009Date of Patent: April 9, 2013Assignee: BASF SEInventors: Knut Eger, Jens Uwe Faust, Holger Borchert, Ralf Streibert, Klaus Joachim Mueller-Engel, Andreas Raichle
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Patent number: 8415269Abstract: A supported palladium-gold catalyst is produced under mild conditions using a commonly available base, such as sodium hydroxide (NaOH) or sodium carbonate (Na2CO3). In this method, support materials and a base solution are mixed together and the temperature of the mixture is increased to a temperature above room temperature. Then, palladium salt and gold salt are added to the mixture while maintaining the pH of the mixture to be greater than 7.0 and keeping the mixture at a temperature above room temperature. This is followed by cooling the mixture while adding acetic acid to maintain the pH of the mixture to be within a desired pH range, filtering out the supported palladium-gold particles, washing with a pH buffer solution and calcining.Type: GrantFiled: January 13, 2010Date of Patent: April 9, 2013Assignee: WGCH Technology LimitedInventors: Xianghong Hao, Ramesh Sharma, Geoffrey McCool, Brian Harrison, Dietmar Wahl
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Patent number: 8415270Abstract: A heat-sensitive recording material comprises a support, a heat-sensitive recording layer including a leuco dye and a developer, and a protective layer comprising a pigment and a binder. The heat-sensitive recording layer is located between the support and the protective layer. The pigment in the protective layer comprises secondary particles with an average particle diameter of about 30 to 900 nm formed preferably by aggregation of amorphous silica primary particles with a particle diameter of about 3 to 70 nm. The secondary particles are present in a proportion of about 5 to 35 mass % relative to total solids of the protective layer. The colloidal silica is present in a proportion of about 1 to 25 mass % relative to total solids of the protective layer.Type: GrantFiled: January 27, 2010Date of Patent: April 9, 2013Assignee: Kanzaki Specialty PapersInventors: Hidenori Yada, Shigetoshi Seki
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Patent number: 8415271Abstract: Strains of psychrophilic bacteria isolated from the rizosphere of Deschampsia antarctica are characterized and biofertilizer compositions comprising one or more of these psychrophilic bacteria strains are disclosed.Type: GrantFiled: April 21, 2008Date of Patent: April 9, 2013Assignee: Uxmal S.A.Inventors: Manuel Gidekel, Ana Gutierrez, Leticia Barrientos, Gustavo Cabrera, Graciela Berrios, Ivan Mihovilovic
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Patent number: 8415272Abstract: Compounds of the general Formula (1) wherein the substituents are as defined in claim 1, are useful as fungicides.Type: GrantFiled: January 8, 2009Date of Patent: April 9, 2013Assignee: Syngenta Crop Protection LLCInventors: Fiona Murphy Kessabi, Laura Quaranta, Renaud Beaudegnies, Hans-Georg Brunner, Fredrik Cederbaum
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Patent number: 8415273Abstract: The present invention provides a broadleaf perennial weed control agent for grass, which has a powerful herbicide effect on weeds that have proven difficult to control with conventional herbicides for grass and/or on weeds having resistance to conventional herbicides, and yet is safe for use on grasses; and a method for controlling broadleaf perennial weeds in grass by applying the control agent to the soil or the foliage.Type: GrantFiled: February 1, 2008Date of Patent: April 9, 2013Assignee: Nippon Soda Co., Ltd.Inventors: Akira Ohno, Yasuji Okunishi, Takashi Sato
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Patent number: 8415274Abstract: Novel active compound combinations comprising a carboxamide of the general formula (I) (group 1) in which A, R1, R2 and R3 are as defined in the description, and the active compound groups (2) to (23) listed in the description have very good fungicidal properties.Type: GrantFiled: September 28, 2004Date of Patent: April 9, 2013Assignee: Bayer CropScience AGInventors: Ulrike Wachendorff-Neumann, Peter Dahmen, Ralf Dunkel, Hans-Ludwig Elbe, Anne Suty-Heinze, Heiko Rieck
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Patent number: 8415275Abstract: The present invention relates to the use of LCOs in initiating earlier flowering, increased number of buds and flower buds and earlier fruit development in non legume and legume plants, as compared to flowering and fruit development under conditions without use of LCOs, and the enhancement of plant growth and yield associated therewith; to compositions comprising an effective amount of at least one LCO and agriculturally acceptable carriers, associated with earlier flowering, increased bud and flower numbers and earlier initiation of fruit development as compared to conditions without use of LCOs, and with increased growth and plant yield; and to methods using LCOs and compositions of one or more LCOs and agriculturally acceptable carriers, associated with earlier flowering initiation, increased bud and flower numbers and earlier fruit development in both legume and non-legume crop plants as compared to conditions without use of LCOs and associated enhancement of growth and yield.Type: GrantFiled: April 22, 2004Date of Patent: April 9, 2013Assignee: Novozymes Biologicals Holding A/SInventors: Chunquan Chen, Ewa Maria Cholewa, John David McIver, Birgit Carolyn Schultz, Yang Yang
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Method for operating a superconductor at a temperature higher than the superconductive temperature T
Patent number: 8415276Abstract: A method of operating a superconductor in its superconductivity state at a temperature Tc(i) in the range of Tc* to Tc, where Tc* is greater than the superconductivity temperature Tc of the superconductor, includes cooling the superconductor to a temperature of Tc or less and applying energy to the superconductor after the superconductor has entered a superconducting state. The energy corresponds to the quantum energy h? in the range of a minimum energy less than E0 to less than E0, where E0 is the ground state of the two-dimensional excitation binding energy of the superconductor The superconductor is then cooled to the selected temperature Tc(i). The minimum energy is 8/9 of E0.Type: GrantFiled: December 26, 2006Date of Patent: April 9, 2013Assignee: CZT Inc.Inventors: Susana Curatolo, Kai Wai Wong -
Patent number: 8415277Abstract: Provided are a bi-functional compound that is positively charged at a first pH and negatively charged at a second pH, a solid support having the bi-functional compound immobilized thereon, and a method of isolating a nucleic acid, including: binding the bi-functional compound with a nucleic acid at a first pH and isolating the nucleic acid from the bi-functional compound at a second pH.Type: GrantFiled: September 8, 2009Date of Patent: April 9, 2013Assignee: Samsung Electronics Co., Ltd.Inventors: Kyu-youn Hwang, Joon-ho Kim
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Patent number: 8415278Abstract: A composition for treating a portion of a wellbore or a portion of a subterranean formation is provided, the composition comprising: (a) water; (b) a source of hydrogen peroxide, and (c) an activator for the source of hydrogen peroxide; wherein the pH of the composition is adjusted to be within an appropriate range for the type of activator. A method for treating a portion of a wellbore or a portion of a subterranean formation, the method comprising the steps of: forming or providing a composition comprising: (a) water; (b) a source of hydrogen peroxide, and (c) an activator for the source of hydrogen peroxide; wherein the pH of the composition is adjusted within an appropriate range for the type of activator; and introducing the composition through a wellbore to treat a portion of a wellbore or a portion of a subterranean formation. The activator can be a water-soluble alkanoyl-donor compound or a chelated transition metal. Preferably, the composition further comprises an iron chelating agent.Type: GrantFiled: March 3, 2011Date of Patent: April 9, 2013Assignee: Halliburton Energy Services, Inc.Inventors: Michael W. Sanders, Jeffrey L. Mundy, Fong Fong Foo, Rajesh K. Saini
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Patent number: 8415279Abstract: Nanoemulsions, miniemulsions, microemulsion systems with excess oil or water or both (Winsor III) or single phase microemulsions (Winsor IV) may be pre-formed and used as one or more fluid pills during hydrocarbon recovery operations after drilling with OBM or SBM. The nanoemulsions, miniemulsions, microemulsion systems with excess oil or water or both or single phase microemulsions remove oil and solids from the well and wellbore surfaces. In one non-limiting embodiment, a single phase microemulsion (SPME) or other pre-formed fluid may be created from a polar phase, a nonpolar phase, an optional viscosifier, and at least one surfactant.Type: GrantFiled: April 21, 2010Date of Patent: April 9, 2013Assignee: Baker Hughes IncorporatedInventors: Lirio Quintero, Chad F. Christian, Alexander McKellar, Cristina Torres, David E. Clark, Thomas A. Jones
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Patent number: 8415280Abstract: A penetrating lubricant with the capacity to offer a both penetration into rust and corrosion. Further, this lubricant actively penetrates the crystalline surface of the metal while exhibiting extreme pressure lubrication, non-migrating with lasting protection. Further lubricant exhibits dielectric strength of over 8000 volts, at the same time cleaning electrical contacts, thereby reducing resistance and associated heat. The preferred embodiment may contain alpha-olefins, low-odor aromatic solvents, base oils, and high flash mineral spirits.Type: GrantFiled: December 2, 2011Date of Patent: April 9, 2013Assignee: BestLine International Research, Inc.Inventor: Ronald J. Sloan
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Patent number: 8415281Abstract: A sliding resin composition is provided which rapidly forms a transfer adhesion film of PTFE on the surface of a counter member at the initial stage of sliding. That is, in the case of using resin composition 1 which is in such a state that particles of PTFE 3 having PTFE film forming agent 4 embedded are dispersed in synthetic resin 2, when the surface of particles of PTFE 3 on the sliding surface of resin composition 1 contacts with the surface of an associated shaft, the PTFE film forming agent 4 is also present at the contact portion, whereby transfer adhesion of PTFE 3 to the surface of the associated shaft is accelerated and thus the time required for decrease of coefficient of friction can be shortened.Type: GrantFiled: September 29, 2010Date of Patent: April 9, 2013Assignee: Daido Metal Company Ltd.Inventor: Hideki Iwata
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Patent number: 8415282Abstract: The lubricating oil composition of the present invention comprises a base oil for lubricating oil, (A) at least one species selected from the phosphorus compounds represented by the following General Formula (1) or (2) as well as metal salts (excluding molybdenum salts) and amine salts thereof, and (B) an organic molybdenum compound not containing sulfur as a constituent element (in the formula, R1 and R4 represent hydrocarbon groups having 1 to 30 carbons, R2, R3, R5 and R6 represent hydrogen atoms or hydrocarbon groups having 1 to 30 carbons, X1 to X7 represent oxygen atoms or sulfur atoms, and n represents 0 or 1).Type: GrantFiled: September 26, 2005Date of Patent: April 9, 2013Assignee: Nippon Oil CorporationInventor: Kazuhiro Yagishita
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Patent number: 8415283Abstract: The invention provides lubricant compositions for diesel engines having a regenerative DPF, which prolong life of the DPF by inhibiting accumulation of components depositable on DPF inner walls, diesel engine systems having a regenerative DPF with prolonged life, and a method for inhibiting accumulation of components depositing on the DPF in the system. The present composition is for diesel engines having a regenerative DPF and running on diesel fuel with <10 mass ppm sulfur, contains a base oil and additives including (A) metal detergent, (B) ashless dispersant, and (C) phosphorus-based anti-wear agent, and satisfies the conditions of a sulfated ash content of 0.4-2 mass %, an atomic ratio of metal from component (A) to the total phosphorus of 0.2-3, an atomic ratio of the total boron to metal from component (A) of 0.2-2, and an atomic ratio of the total sulfur to metal from component (A) of 0-4.Type: GrantFiled: February 19, 2010Date of Patent: April 9, 2013Assignees: Nippon Oil Corporation, Japan Petroleum Energy CenterInventors: Isao Kurihara, Mineo Kagaya
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Patent number: 8415284Abstract: A lubricating oil composition and methods of operating an internal combustion engine to provide improved engine operation. The lubricating composition includes a major amount of oil of lubricating viscosity and a minor amount of at least one olefin copolymer having a number average molecular weight greater than about 10,000 up to about 300,000. The olefin copolymer is grafted with (A) a vinyl-substituted aromatic compound, and (B) a compound selected from the group consisting of a C5-C30 olefin, a polyalkylene compound, and mixtures thereof. A mole ratio of A/B in the reaction mixture ranges from about 0.25:1 to about 5:1. The lubricating composition optionally includes a minor amount of at least one non-grafted olefin copolymer, styrene-isoprene copolymer, methacrylate copolymer, or styrene butadiene copolymer have number average molecular weight greater than about 50,000 up to about 300,000.Type: GrantFiled: November 5, 2009Date of Patent: April 9, 2013Assignee: Afton Chemical CorporationInventor: Akhilesh Duggal
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Patent number: 8415285Abstract: The present invention provides compositions, in particular blocks, tablets and gels, for the prevention or removal of insoluble salt deposits comprising: a) an organic acid with two carboxylic acid functional groups obtainable by fermentation, selected from the list of itaconic acid, itaconic acid anhydride, succinic acid, succinic anhydride and combinations thereof, and b) at least one compound determining the release of said acid from said composition, said compound is selected from a list comprising: i) a hygroscopic compound, ii) a carbonate source, iii) an acid solubility retarding compound, iv) a compound with melting point situated between 60° C.-95° C., and combinations thereof. The invention further provides uses of the compositions for the prevention or removal of insoluble salt deposits. The invention also provides a method of manufacturing such compositions and a method for the prevention or removal of insoluble salt deposits with a product of the invention.Type: GrantFiled: January 31, 2011Date of Patent: April 9, 2013Assignee: Ecover Coordination Center N.V.Inventors: Dirk Willem Godfried Develter, Luc Marc Leonie Lauryssen
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Patent number: 8415286Abstract: The present invention is directed toward an oil dispersant composition useful in treating oil spills, and for cleanup of the shoreline, animals, plants, and equipment. The oil dispersant product is a non-toxic, solvent-free composition which efficiently breaks down grease, grime and crude oil at the molecular level, by breaking down the hydrocarbon chains and preventing the oil molecules from ever reforming again.Type: GrantFiled: June 13, 2012Date of Patent: April 9, 2013Assignee: Green On Industries Inc.Inventor: Terrence J. McGuire
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Patent number: 8415287Abstract: The present invention relates to personal care compositions, especially those personal care compositions in the form of a personal care article that is a porous dissolvable solid substrate. The porous dissolvable solid substrate has a surface resident coating comprising an inorganic particulate perfume complex that can provide a consumer benefit.Type: GrantFiled: December 8, 2009Date of Patent: April 9, 2013Assignee: The Procter & Gamble CompanyInventors: Robert Wayne Glenn, Jr., Kathy Mary Kaufman
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Patent number: 8415288Abstract: The present invention relates to the therapeutic and prophylactic use of C1 inhibitor for preventing, reducing and treating ischemia and reperfusion injury. The C1 inhibitor of the present invention is still therapeutically effective when administered after an ischemic period and reperfusion and therefore particularly useful for unforeseen occurrences of ischemic reperfusion such as e.g. a stroke.Type: GrantFiled: October 11, 2011Date of Patent: April 9, 2013Assignee: Pharming Intellectual Property B.V.Inventors: Maurice Mannesse, Johannes Henricus Nuijens, Frank Pieper, Maria Grazia De Simoni, Gijsbertus Johannes Ziere
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Patent number: 8415289Abstract: This invention relates to a treatment of acne. Specifically, the invention is directed to the use of bacteriocin-like inhibitory substances (BLIS), isolated from S. salivarius as bactericide or bacteriostat for acne-causing bacteria, namely P. acnes.Type: GrantFiled: December 13, 2006Date of Patent: April 9, 2013Assignee: The Trustees of the University of PennsylvaniaInventors: David Margolis, Whitney Bowe
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Patent number: 8415290Abstract: Protein hydrogel monomers incorporating bio-active proteins and methods for producing the same are provided. In some embodiments, the disclosed subject matter includes a protein hydrogel monomer including a bio-active protein and two alpha helices that are adapted to interact with alpha helices on other monomers to form coiled-coil junctions.Type: GrantFiled: October 10, 2008Date of Patent: April 9, 2013Assignee: The Trustees of Columbia University in the City of New YorkInventors: Scott Banta, Scott Andrew Calabrese Barton, Ian R. Wheeldon
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Patent number: 8415291Abstract: A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, preferably human Tenascin, that binds to human TNF? including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.Type: GrantFiled: October 27, 2009Date of Patent: April 9, 2013Assignee: Centocor Ortho Biotech Inc.Inventors: Steven Jacobs, Karyn O'Neil
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Patent number: 8415292Abstract: The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction between CAL and mutant CFTR proteins, thereby stabilizing the CFTR and facilitating transport of the same to the cell surface.Type: GrantFiled: October 20, 2009Date of Patent: April 9, 2013Assignee: Trustees of Dartmouth CollegeInventors: Dean Madden, Patrick R. Cushing, Prisca Boinguérin, Rudolf Volkmer, Lars Vouilleme
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Patent number: 8415293Abstract: The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABAC1 that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.Type: GrantFiled: June 17, 2009Date of Patent: April 9, 2013Assignee: The Regents of the University of CaliforniaInventors: John K. Bielicki, Jan Johansson
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Patent number: 8415294Abstract: The present invention is directed to cyclodepsipeptide compounds having antineoplastic and/or antimicrobial activity, preferably Kitastatin 1. The present invention is further directed to methods of inhibiting cancer cell growth and/or microbial growth in a host inflicted therewith by administering cyclodepsipeptide compounds to the inflicted host.Type: GrantFiled: June 5, 2008Date of Patent: April 9, 2013Assignee: Arizona Board of RegentsInventors: George R. Pettit, Rui Tan, Robin K. Pettit
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Patent number: 8415295Abstract: Dipeptidyl peptidase IV (DPP-IV)-inhibiting compounds are provided that have formula I: wherein n is 1 to 3; X is CH2; S; O; CF2 or C(CH3)2; Z is H; halogen; hydroxyl; (C1-6)alkoxy; (C1-12)alkyl; (C3-12)cycloalkyl; phenyl; or heteroaryl; where the phenyl and heteroaryl groups are optionally mono- or independently plurisubstituted with R7; optionally, X together with an adjacent ring carbon and Z form a fused cyclopropyl; and optionally, one of the bonds in the ring containing X is a double bond; and CriRii, R1, R1, R3, R4 and R5 are as described herein. Methods for preparing these compounds, and methods for treating diabetes, especially Type II diabetes, and other related diseases are described using the compounds of formula I in pharmaceutical compositions which contain these compounds. Pharmaceutical compositions which contain combinations of these compounds with other antidiabetic agents are also described herein.Type: GrantFiled: January 22, 2010Date of Patent: April 9, 2013Assignee: Phenomix CorporationInventors: David Alan Campbell, David T. Winn, Juan Manuel Betancort
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Patent number: 8415296Abstract: The present invention provides Oxyntomodulin peptide analogues useful in the treatment of diabetes and/or obesity.Type: GrantFiled: December 15, 2010Date of Patent: April 9, 2013Assignee: Eli Lilly and CompanyInventors: Jorge Alsina-Fernandez, Wayne David Kohn
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Patent number: 8415297Abstract: The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.Type: GrantFiled: February 17, 2012Date of Patent: April 9, 2013Assignee: Merck Sharp & Dohme Corp.Inventors: Tesfaye Biftu, Ann E. Weber
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Patent number: 8415298Abstract: The present invention provides methods for diagnosing mental disorders. The invention also provides methods of identifying modulators of mental disorders as well as methods of using these modulators to treat patients suffering from mental disorders.Type: GrantFiled: June 21, 2005Date of Patent: April 9, 2013Assignee: The Board of Trustees of the Leland Stanford Junior University of StanfordInventors: Huda Akil, William E. Bunney, Jr., Prabhakara V. Choudary, Simon J. Evans, Edward G. Jones, Jun Li, Juan F. Lopez, David M. Lyons, Margherita Molnar, Richard M. Myers, Alan F. Schatzberg, Richard Stein, Robert C. Thompson, Hiroaki Tomita, Marquis P. Vawter, Stanley J. Watson
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Patent number: 8415299Abstract: A method is disclosed which is useful for elevating blood thyroid hormone levels in avian species (especially poultry species such as chickens, turkeys, ducks, quail, etc.) by implantation, injection, or supplementation of feed or water with thyroid hormones or thyroid-active substances (e.g., L-thyroxine, triiodothyronine, defatted and dessicated thyroid) to induce molting in order to extend egg production.Type: GrantFiled: July 7, 2005Date of Patent: April 9, 2013Inventors: Danny Michael Hooge, Robert Frederick Wideman, Jr., Wayne John Kuenzel
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Patent number: 8415300Abstract: A fluid, milky microcrystalline aqueous suspension of a peptide or peptidomimetic and a counter-ion of a strong proton donor in water, wherein the peptide or peptidomimetic and counter-ion are present in amounts and at a molar ratio sufficient to form the suspension upon mixing and without formation of a gel. Also, lyophilized compositions that include a dried suspension, methods of making the lyophilized composition, methods of preparing the suspension, and sustained release formulations prepared by the methods.Type: GrantFiled: September 1, 2011Date of Patent: April 9, 2013Assignee: Medical Research Council TechnologyInventors: Romano Deghenghi, Francois Boutignon
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Patent number: 8415301Abstract: The disclosure pertains to methods of reducing decompensation through acute intervention including in subjects afflicted with acute decompensated heart failure. Particularly, the disclosure provides methods for treating acute cardiac decompensation by administering a pharmaceutically effective amount of relaxin.Type: GrantFiled: May 15, 2009Date of Patent: April 9, 2013Assignee: Corthera, Inc.Inventors: Elaine Unemori, Sam L Teichman, Gad Cotter, Dennis R Stewart, Martha J Whitehouse
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Patent number: 8415302Abstract: The present invention relates to the clinical application of BBP, alone or in combination with other growth factors, for use in bone healing applications, such as spinal surgery. Additional applications include use in orthopedic implantable prostheses and implantation into other surgical sites (e.g., surgical reconstruction, regional osteopenia, etc.) where bone is desired.Type: GrantFiled: December 26, 2007Date of Patent: April 9, 2013Assignees: The Regents of the University of California, The United States of America as Represented by the Department of Veterans AffairsInventors: Samuel S. Murray, Elsa J. Brochmann-Murray, Keyvan Behnam, Jeffrey C. Wang
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Patent number: 8415303Abstract: The present invention relates to nucleotide sequences of vertebrate Delta genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In a specific embodiment, the vertebrate Delta protein is a human protein. The invention further relates to fragments (and derivatives and analogs thereof) of Delta which comprise one or more domains of the Delta protein, including but not limited to the intracellular domain, extracellular domain, DSL domain, domain amino-terminal to the DSL domain, transmembrane region, or one or more EGF-like repeats of a Delta protein, or any combination of the foregoing. Antibodies to Delta, its derivatives and analogs, are additionally provided. Methods of production of the Delta proteins, derivatives and analogs, e.g., by recombinant means, are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are provided.Type: GrantFiled: October 10, 2006Date of Patent: April 9, 2013Assignees: Imperial Cancer Research Technology, Ltd., Yale UniversityInventors: David Ish-Horowicz, Domingos Manuel Pinto Henrique, Julian Hart Lewis, Spyridon Artavanis-Tsakonas, Grace E. Gray
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Patent number: 8415304Abstract: The invention provides methods for predicting or determining the response of a mammalian tumor to a chemotherapeutic agent and for treating a mammalian tumor comprising detecting and quantifying the SPARC protein or RNA in a sample isolated from the mammal. The invention further provides kit for predicting the response of a mammalian tumor to a chemotherapeutic agent, comprising a means for the isolation of protein or RNA from the tumor, a SPARC protein or RNA detection and quantification means, control RNAs, and rules for predicting the response of the tumor based on the level of SPARC protein or RNA in tumor.Type: GrantFiled: March 29, 2007Date of Patent: April 9, 2013Assignee: Abraxis BioScience, LLCInventors: Vuong Trieu, Neil P. Desai, Patrick Soon-Shiong
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Patent number: 8415305Abstract: The present application relates to cyclic depsipeptides of Formula I: or derivatives thereof, wherein X, A1, A2, A3, A4, A5, A6 and A7 are defined herein. The cyclic depsipeptides of Formula I are inhibitors of kallikrein 7 and thus can be employed for the treatment of kallikrein-7 dependent diseases.Type: GrantFiled: August 14, 2008Date of Patent: April 9, 2013Assignee: Novartis AGInventors: Philipp Krastel, Brigitta-Maria Liechty, Esther Schmitt, Erwin Paul Schreiner
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Patent number: 8415306Abstract: The present invention relates to insulin-like growth factor 1 receptor binding peptides, polynucleotides encoding them, and methods of making and using the foregoing.Type: GrantFiled: May 25, 2011Date of Patent: April 9, 2013Assignee: Janssen Biotech, Inc.Inventors: Michael Diem, Karyn O'Neil