Patents Issued in April 9, 2013
  • Patent number: 8415257
    Abstract: Amorphous carbon material may be deposited with superior adhesion on dielectric materials, such as TEOS based silicon oxide materials, in complex semiconductor devices by applying a plasma treatment, such as an argon treatment and/or forming a thin adhesion layer based on silicon dioxide, carbon-doped silicon dioxide, prior to depositing the carbon material. Consequently, the hard mask concept based on amorphous carbon may be applied with an increased degree of flexibility, since a superior adhesion may allow a higher degree of flexibility in selecting appropriate deposition parameters for the carbon material.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: April 9, 2013
    Assignee: GLOBALFOUNDRIES Inc.
    Inventors: Hartmut Ruelke, Volker Jaschke
  • Patent number: 8415258
    Abstract: Provided is a method of manufacturing a semiconductor device. The method includes: loading a substrate into a process vessel; performing a process to form an film on the substrate by alternately repeating: (a) forming a layer containing an element on the substrate by supplying at least two types of source gases into the process vessel, each of the at least two types of source gases containing the element, and (b) changing the layer containing the element by supplying reaction gas into the process vessel, the reaction gas being different from the at least two types of source gases; and unloading the processed substrate from the process vessel.
    Type: Grant
    Filed: November 1, 2011
    Date of Patent: April 9, 2013
    Assignee: Hitachi Kokusai Electric Inc.
    Inventors: Naonori Akae, Yoshiro Hirose, Yushin Takasawa, Yosuke Ota, Ryota Sasajima
  • Patent number: 8415259
    Abstract: A method of forming a film on a semiconductor substrate by plasma enhanced atomic layer deposition (PEALD), includes: introducing a nitrogen- and hydrogen-containing reactive gas and a rare gas into a reaction space inside which the semiconductor substrate is placed; introducing a precursor in pulses of less than 1.0-second duration into the reaction space wherein the reactive gas and the rare gas are introduced; exiting a plasma in pulses of less than 1.0-second duration immediately after the precursor is shut off; and maintaining the reactive gas and the rare gas as a purge of less than 2.0-second duration.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: April 9, 2013
    Assignee: ASM Japan K.K.
    Inventors: Woo Jin Lee, Kuo-Wei Hong, Akira Shimizu, Daekyun Jeong
  • Patent number: 8415260
    Abstract: A chip identification for organic laminate packaging and methods of manufacture is provided. The method includes forming a material on a wafer which comprises a plurality of chips. The method further includes modifying the material to provide a unique identification for each of the plurality of chips on the wafer. The organic laminate structure includes a chip with a device and a material placed on the chip which is modified to have a unique identification mark for the chip.
    Type: Grant
    Filed: April 8, 2010
    Date of Patent: April 9, 2013
    Assignee: International Business Machines Corporation
    Inventors: Albert J. Banach, Timothy H. Daubenspeck, Wolfgang Sauter
  • Patent number: 8415261
    Abstract: Methods of forming a capping layer on conductive lines in a semiconductor device may be characterized by the following operations: (a) providing a semiconductor substrate comprising a dielectric layer having (i) exposed conductive lines (e.g., copper lines) disposed therein, and (ii) an exposed barrier layer disposed thereon; and (b) depositing a capping layer material on at least the exposed conductive lines of the semiconductor substrate. In certain embodiments, the method may also involve removing at least a portion of a conductive layer (e.g., overburden) disposed over the barrier layer and conductive lines to expose the barrier layer.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: April 9, 2013
    Assignee: Novellus Systems, Inc.
    Inventors: Jonathan D. Reid, Eric G. Webb, Edmund B. Minshall, Avishai Kepten, R. Marshall Stowell, Steven T. Mayer
  • Patent number: 8415262
    Abstract: Porous fibrous sheets are provided that are useful in end uses requiring microbial barrier properties such as medical packaging and medical gowns and drapes. The porous fibrous sheets may contain nanofibers and wood pulp.
    Type: Grant
    Filed: October 22, 2004
    Date of Patent: April 9, 2013
    Assignee: E I du Pont de Nemours and Company
    Inventors: Ioannis V. Bletsos, Joseph Robert Guckert, Mikhail R. Levit, David Carl Roberts
  • Patent number: 8415263
    Abstract: A composite material as a sheet material is described, being relatively cheap, most useful as a raw material of a sanitary product or the like, such as underwear, dust-proof mask or dispensable paper diaper, etc., and good in processability, stretchability, gas-permeability, softness, and touch. The composite material is formed by laminating a stretchable layer and a conjugate spunbonded nonwoven fabric including conjugate fibers including a low-melting-point component and a high-melting-point component. The conjugate fibers are partially bonded to each other by thermocompression, wherein each bonded portion has fine folded structures including alternate hill and valley regions in the CD, and the distance between neighboring hills is 100-400 ?m in average. The conjugate spunbonded nonwoven fabric exhibits stretchability through the spread of the fine folded structures, and has, at 5% elongation, a CD-strength of 0.1 N/5 cm or less and an MD/CD strength ratio of 200 or more.
    Type: Grant
    Filed: March 30, 2011
    Date of Patent: April 9, 2013
    Assignees: JNC Corporation, JNC Fibers Corporation
    Inventors: Toshikatsu Fujiwara, Taiju Terakawa
  • Patent number: 8415264
    Abstract: One exemplary embodiment can be a process for regenerating catalyst in a fluid catalytic cracking unit. Generally, the process includes providing a feed to a riser of a reaction vessel, and providing a stream to a distributor positioned within a void proximate to an inlet receiving unregenerated catalyst in a regenerator. The feed can include at least one of a gas oil, a vacuum gas oil, an atmospheric gas oil, a coker gas oil, a hydrotreated gas oil, a hydrocracker unconverted oil, and an atmospheric residue.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: April 9, 2013
    Assignee: UOP LLC
    Inventors: Daniel N. Myers, Paolo Palmas, David Nathan Myers
  • Patent number: 8415265
    Abstract: A process for the preparation of melamine by decomposition of urea with the use of a catalyst, the catalyst comprising a) 10-90% by weight of zeolite, b) 10-90% by weight of a matrix comprising silica, alumina, silicon aluminum oxides and/or clay minerals, and c) 0-10% by weight of additives and the total content of nickel and vanadium in the catalyst being less than 500 ppm.
    Type: Grant
    Filed: May 21, 2008
    Date of Patent: April 9, 2013
    Assignee: BASF SE
    Inventors: Christian Kuhrs, Andreas Kern, Tilo John, Wolfgang Steiner, Heiko Maas
  • Patent number: 8415266
    Abstract: The invention relates to catalyst components, containing: (A) at least one Brönsted acid, (B) water, (C) at least one antacid-acting compound from the group consisting of the oxides, hydroxides, carbonates and/or carboxylates of the elements aluminum, chromium, copper, germanium, manganese, lead, antimony, tin, tellurium, titanium and/or zinc, (D) optionally at least one inert diluent, (E) optionally at least one modifier, the mixture of one part by weight of the catalyst component with three parts by weight bisaziridino polyether with an average imino equivalent mass of 3100, preparable from a polyetherdiol which comprises ethylene oxide and tetrahydrofuran units in the molar ratio 1:3.5 solidifying within 0.5 to 20 minutes to a solid elastomer material which has a shore A hardness of at least 20 according to DIN 53505 after 24 hours' storage time at room temperature.
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: April 9, 2013
    Assignee: 3M Deutschland GmbH
    Inventors: Gunther Eckhardt, Erich Wanek, Bernd Kuppermann
  • Patent number: 8415267
    Abstract: Core-shell nanoparticles having a core material and a mesoporous silica shell, and a method for manufacturing the core-shell nanoparticles are provided.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: April 9, 2013
    Assignee: Korea University Research and Business Foundation
    Inventor: Kwangyeol Lee
  • Patent number: 8415268
    Abstract: A process for producing a ringlike oxidic shaped body by mechanically compacting a pulverulent aggregate introduced into the fill chamber of a die, wherein the outer face of the resulting compact corresponds to that of a frustocone.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: April 9, 2013
    Assignee: BASF SE
    Inventors: Knut Eger, Jens Uwe Faust, Holger Borchert, Ralf Streibert, Klaus Joachim Mueller-Engel, Andreas Raichle
  • Patent number: 8415269
    Abstract: A supported palladium-gold catalyst is produced under mild conditions using a commonly available base, such as sodium hydroxide (NaOH) or sodium carbonate (Na2CO3). In this method, support materials and a base solution are mixed together and the temperature of the mixture is increased to a temperature above room temperature. Then, palladium salt and gold salt are added to the mixture while maintaining the pH of the mixture to be greater than 7.0 and keeping the mixture at a temperature above room temperature. This is followed by cooling the mixture while adding acetic acid to maintain the pH of the mixture to be within a desired pH range, filtering out the supported palladium-gold particles, washing with a pH buffer solution and calcining.
    Type: Grant
    Filed: January 13, 2010
    Date of Patent: April 9, 2013
    Assignee: WGCH Technology Limited
    Inventors: Xianghong Hao, Ramesh Sharma, Geoffrey McCool, Brian Harrison, Dietmar Wahl
  • Patent number: 8415270
    Abstract: A heat-sensitive recording material comprises a support, a heat-sensitive recording layer including a leuco dye and a developer, and a protective layer comprising a pigment and a binder. The heat-sensitive recording layer is located between the support and the protective layer. The pigment in the protective layer comprises secondary particles with an average particle diameter of about 30 to 900 nm formed preferably by aggregation of amorphous silica primary particles with a particle diameter of about 3 to 70 nm. The secondary particles are present in a proportion of about 5 to 35 mass % relative to total solids of the protective layer. The colloidal silica is present in a proportion of about 1 to 25 mass % relative to total solids of the protective layer.
    Type: Grant
    Filed: January 27, 2010
    Date of Patent: April 9, 2013
    Assignee: Kanzaki Specialty Papers
    Inventors: Hidenori Yada, Shigetoshi Seki
  • Patent number: 8415271
    Abstract: Strains of psychrophilic bacteria isolated from the rizosphere of Deschampsia antarctica are characterized and biofertilizer compositions comprising one or more of these psychrophilic bacteria strains are disclosed.
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: April 9, 2013
    Assignee: Uxmal S.A.
    Inventors: Manuel Gidekel, Ana Gutierrez, Leticia Barrientos, Gustavo Cabrera, Graciela Berrios, Ivan Mihovilovic
  • Patent number: 8415272
    Abstract: Compounds of the general Formula (1) wherein the substituents are as defined in claim 1, are useful as fungicides.
    Type: Grant
    Filed: January 8, 2009
    Date of Patent: April 9, 2013
    Assignee: Syngenta Crop Protection LLC
    Inventors: Fiona Murphy Kessabi, Laura Quaranta, Renaud Beaudegnies, Hans-Georg Brunner, Fredrik Cederbaum
  • Patent number: 8415273
    Abstract: The present invention provides a broadleaf perennial weed control agent for grass, which has a powerful herbicide effect on weeds that have proven difficult to control with conventional herbicides for grass and/or on weeds having resistance to conventional herbicides, and yet is safe for use on grasses; and a method for controlling broadleaf perennial weeds in grass by applying the control agent to the soil or the foliage.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: April 9, 2013
    Assignee: Nippon Soda Co., Ltd.
    Inventors: Akira Ohno, Yasuji Okunishi, Takashi Sato
  • Patent number: 8415274
    Abstract: Novel active compound combinations comprising a carboxamide of the general formula (I) (group 1) in which A, R1, R2 and R3 are as defined in the description, and the active compound groups (2) to (23) listed in the description have very good fungicidal properties.
    Type: Grant
    Filed: September 28, 2004
    Date of Patent: April 9, 2013
    Assignee: Bayer CropScience AG
    Inventors: Ulrike Wachendorff-Neumann, Peter Dahmen, Ralf Dunkel, Hans-Ludwig Elbe, Anne Suty-Heinze, Heiko Rieck
  • Patent number: 8415275
    Abstract: The present invention relates to the use of LCOs in initiating earlier flowering, increased number of buds and flower buds and earlier fruit development in non legume and legume plants, as compared to flowering and fruit development under conditions without use of LCOs, and the enhancement of plant growth and yield associated therewith; to compositions comprising an effective amount of at least one LCO and agriculturally acceptable carriers, associated with earlier flowering, increased bud and flower numbers and earlier initiation of fruit development as compared to conditions without use of LCOs, and with increased growth and plant yield; and to methods using LCOs and compositions of one or more LCOs and agriculturally acceptable carriers, associated with earlier flowering initiation, increased bud and flower numbers and earlier fruit development in both legume and non-legume crop plants as compared to conditions without use of LCOs and associated enhancement of growth and yield.
    Type: Grant
    Filed: April 22, 2004
    Date of Patent: April 9, 2013
    Assignee: Novozymes Biologicals Holding A/S
    Inventors: Chunquan Chen, Ewa Maria Cholewa, John David McIver, Birgit Carolyn Schultz, Yang Yang
  • Patent number: 8415276
    Abstract: A method of operating a superconductor in its superconductivity state at a temperature Tc(i) in the range of Tc* to Tc, where Tc* is greater than the superconductivity temperature Tc of the superconductor, includes cooling the superconductor to a temperature of Tc or less and applying energy to the superconductor after the superconductor has entered a superconducting state. The energy corresponds to the quantum energy h? in the range of a minimum energy less than E0 to less than E0, where E0 is the ground state of the two-dimensional excitation binding energy of the superconductor The superconductor is then cooled to the selected temperature Tc(i). The minimum energy is 8/9 of E0.
    Type: Grant
    Filed: December 26, 2006
    Date of Patent: April 9, 2013
    Assignee: CZT Inc.
    Inventors: Susana Curatolo, Kai Wai Wong
  • Patent number: 8415277
    Abstract: Provided are a bi-functional compound that is positively charged at a first pH and negatively charged at a second pH, a solid support having the bi-functional compound immobilized thereon, and a method of isolating a nucleic acid, including: binding the bi-functional compound with a nucleic acid at a first pH and isolating the nucleic acid from the bi-functional compound at a second pH.
    Type: Grant
    Filed: September 8, 2009
    Date of Patent: April 9, 2013
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Kyu-youn Hwang, Joon-ho Kim
  • Patent number: 8415278
    Abstract: A composition for treating a portion of a wellbore or a portion of a subterranean formation is provided, the composition comprising: (a) water; (b) a source of hydrogen peroxide, and (c) an activator for the source of hydrogen peroxide; wherein the pH of the composition is adjusted to be within an appropriate range for the type of activator. A method for treating a portion of a wellbore or a portion of a subterranean formation, the method comprising the steps of: forming or providing a composition comprising: (a) water; (b) a source of hydrogen peroxide, and (c) an activator for the source of hydrogen peroxide; wherein the pH of the composition is adjusted within an appropriate range for the type of activator; and introducing the composition through a wellbore to treat a portion of a wellbore or a portion of a subterranean formation. The activator can be a water-soluble alkanoyl-donor compound or a chelated transition metal. Preferably, the composition further comprises an iron chelating agent.
    Type: Grant
    Filed: March 3, 2011
    Date of Patent: April 9, 2013
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Michael W. Sanders, Jeffrey L. Mundy, Fong Fong Foo, Rajesh K. Saini
  • Patent number: 8415279
    Abstract: Nanoemulsions, miniemulsions, microemulsion systems with excess oil or water or both (Winsor III) or single phase microemulsions (Winsor IV) may be pre-formed and used as one or more fluid pills during hydrocarbon recovery operations after drilling with OBM or SBM. The nanoemulsions, miniemulsions, microemulsion systems with excess oil or water or both or single phase microemulsions remove oil and solids from the well and wellbore surfaces. In one non-limiting embodiment, a single phase microemulsion (SPME) or other pre-formed fluid may be created from a polar phase, a nonpolar phase, an optional viscosifier, and at least one surfactant.
    Type: Grant
    Filed: April 21, 2010
    Date of Patent: April 9, 2013
    Assignee: Baker Hughes Incorporated
    Inventors: Lirio Quintero, Chad F. Christian, Alexander McKellar, Cristina Torres, David E. Clark, Thomas A. Jones
  • Patent number: 8415280
    Abstract: A penetrating lubricant with the capacity to offer a both penetration into rust and corrosion. Further, this lubricant actively penetrates the crystalline surface of the metal while exhibiting extreme pressure lubrication, non-migrating with lasting protection. Further lubricant exhibits dielectric strength of over 8000 volts, at the same time cleaning electrical contacts, thereby reducing resistance and associated heat. The preferred embodiment may contain alpha-olefins, low-odor aromatic solvents, base oils, and high flash mineral spirits.
    Type: Grant
    Filed: December 2, 2011
    Date of Patent: April 9, 2013
    Assignee: BestLine International Research, Inc.
    Inventor: Ronald J. Sloan
  • Patent number: 8415281
    Abstract: A sliding resin composition is provided which rapidly forms a transfer adhesion film of PTFE on the surface of a counter member at the initial stage of sliding. That is, in the case of using resin composition 1 which is in such a state that particles of PTFE 3 having PTFE film forming agent 4 embedded are dispersed in synthetic resin 2, when the surface of particles of PTFE 3 on the sliding surface of resin composition 1 contacts with the surface of an associated shaft, the PTFE film forming agent 4 is also present at the contact portion, whereby transfer adhesion of PTFE 3 to the surface of the associated shaft is accelerated and thus the time required for decrease of coefficient of friction can be shortened.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: April 9, 2013
    Assignee: Daido Metal Company Ltd.
    Inventor: Hideki Iwata
  • Patent number: 8415282
    Abstract: The lubricating oil composition of the present invention comprises a base oil for lubricating oil, (A) at least one species selected from the phosphorus compounds represented by the following General Formula (1) or (2) as well as metal salts (excluding molybdenum salts) and amine salts thereof, and (B) an organic molybdenum compound not containing sulfur as a constituent element (in the formula, R1 and R4 represent hydrocarbon groups having 1 to 30 carbons, R2, R3, R5 and R6 represent hydrogen atoms or hydrocarbon groups having 1 to 30 carbons, X1 to X7 represent oxygen atoms or sulfur atoms, and n represents 0 or 1).
    Type: Grant
    Filed: September 26, 2005
    Date of Patent: April 9, 2013
    Assignee: Nippon Oil Corporation
    Inventor: Kazuhiro Yagishita
  • Patent number: 8415283
    Abstract: The invention provides lubricant compositions for diesel engines having a regenerative DPF, which prolong life of the DPF by inhibiting accumulation of components depositable on DPF inner walls, diesel engine systems having a regenerative DPF with prolonged life, and a method for inhibiting accumulation of components depositing on the DPF in the system. The present composition is for diesel engines having a regenerative DPF and running on diesel fuel with <10 mass ppm sulfur, contains a base oil and additives including (A) metal detergent, (B) ashless dispersant, and (C) phosphorus-based anti-wear agent, and satisfies the conditions of a sulfated ash content of 0.4-2 mass %, an atomic ratio of metal from component (A) to the total phosphorus of 0.2-3, an atomic ratio of the total boron to metal from component (A) of 0.2-2, and an atomic ratio of the total sulfur to metal from component (A) of 0-4.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: April 9, 2013
    Assignees: Nippon Oil Corporation, Japan Petroleum Energy Center
    Inventors: Isao Kurihara, Mineo Kagaya
  • Patent number: 8415284
    Abstract: A lubricating oil composition and methods of operating an internal combustion engine to provide improved engine operation. The lubricating composition includes a major amount of oil of lubricating viscosity and a minor amount of at least one olefin copolymer having a number average molecular weight greater than about 10,000 up to about 300,000. The olefin copolymer is grafted with (A) a vinyl-substituted aromatic compound, and (B) a compound selected from the group consisting of a C5-C30 olefin, a polyalkylene compound, and mixtures thereof. A mole ratio of A/B in the reaction mixture ranges from about 0.25:1 to about 5:1. The lubricating composition optionally includes a minor amount of at least one non-grafted olefin copolymer, styrene-isoprene copolymer, methacrylate copolymer, or styrene butadiene copolymer have number average molecular weight greater than about 50,000 up to about 300,000.
    Type: Grant
    Filed: November 5, 2009
    Date of Patent: April 9, 2013
    Assignee: Afton Chemical Corporation
    Inventor: Akhilesh Duggal
  • Patent number: 8415285
    Abstract: The present invention provides compositions, in particular blocks, tablets and gels, for the prevention or removal of insoluble salt deposits comprising: a) an organic acid with two carboxylic acid functional groups obtainable by fermentation, selected from the list of itaconic acid, itaconic acid anhydride, succinic acid, succinic anhydride and combinations thereof, and b) at least one compound determining the release of said acid from said composition, said compound is selected from a list comprising: i) a hygroscopic compound, ii) a carbonate source, iii) an acid solubility retarding compound, iv) a compound with melting point situated between 60° C.-95° C., and combinations thereof. The invention further provides uses of the compositions for the prevention or removal of insoluble salt deposits. The invention also provides a method of manufacturing such compositions and a method for the prevention or removal of insoluble salt deposits with a product of the invention.
    Type: Grant
    Filed: January 31, 2011
    Date of Patent: April 9, 2013
    Assignee: Ecover Coordination Center N.V.
    Inventors: Dirk Willem Godfried Develter, Luc Marc Leonie Lauryssen
  • Patent number: 8415286
    Abstract: The present invention is directed toward an oil dispersant composition useful in treating oil spills, and for cleanup of the shoreline, animals, plants, and equipment. The oil dispersant product is a non-toxic, solvent-free composition which efficiently breaks down grease, grime and crude oil at the molecular level, by breaking down the hydrocarbon chains and preventing the oil molecules from ever reforming again.
    Type: Grant
    Filed: June 13, 2012
    Date of Patent: April 9, 2013
    Assignee: Green On Industries Inc.
    Inventor: Terrence J. McGuire
  • Patent number: 8415287
    Abstract: The present invention relates to personal care compositions, especially those personal care compositions in the form of a personal care article that is a porous dissolvable solid substrate. The porous dissolvable solid substrate has a surface resident coating comprising an inorganic particulate perfume complex that can provide a consumer benefit.
    Type: Grant
    Filed: December 8, 2009
    Date of Patent: April 9, 2013
    Assignee: The Procter & Gamble Company
    Inventors: Robert Wayne Glenn, Jr., Kathy Mary Kaufman
  • Patent number: 8415288
    Abstract: The present invention relates to the therapeutic and prophylactic use of C1 inhibitor for preventing, reducing and treating ischemia and reperfusion injury. The C1 inhibitor of the present invention is still therapeutically effective when administered after an ischemic period and reperfusion and therefore particularly useful for unforeseen occurrences of ischemic reperfusion such as e.g. a stroke.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: April 9, 2013
    Assignee: Pharming Intellectual Property B.V.
    Inventors: Maurice Mannesse, Johannes Henricus Nuijens, Frank Pieper, Maria Grazia De Simoni, Gijsbertus Johannes Ziere
  • Patent number: 8415289
    Abstract: This invention relates to a treatment of acne. Specifically, the invention is directed to the use of bacteriocin-like inhibitory substances (BLIS), isolated from S. salivarius as bactericide or bacteriostat for acne-causing bacteria, namely P. acnes.
    Type: Grant
    Filed: December 13, 2006
    Date of Patent: April 9, 2013
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David Margolis, Whitney Bowe
  • Patent number: 8415290
    Abstract: Protein hydrogel monomers incorporating bio-active proteins and methods for producing the same are provided. In some embodiments, the disclosed subject matter includes a protein hydrogel monomer including a bio-active protein and two alpha helices that are adapted to interact with alpha helices on other monomers to form coiled-coil junctions.
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: April 9, 2013
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Scott Banta, Scott Andrew Calabrese Barton, Ian R. Wheeldon
  • Patent number: 8415291
    Abstract: A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, preferably human Tenascin, that binds to human TNF? including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Grant
    Filed: October 27, 2009
    Date of Patent: April 9, 2013
    Assignee: Centocor Ortho Biotech Inc.
    Inventors: Steven Jacobs, Karyn O'Neil
  • Patent number: 8415292
    Abstract: The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction between CAL and mutant CFTR proteins, thereby stabilizing the CFTR and facilitating transport of the same to the cell surface.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: April 9, 2013
    Assignee: Trustees of Dartmouth College
    Inventors: Dean Madden, Patrick R. Cushing, Prisca Boinguérin, Rudolf Volkmer, Lars Vouilleme
  • Patent number: 8415293
    Abstract: The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABAC1 that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.
    Type: Grant
    Filed: June 17, 2009
    Date of Patent: April 9, 2013
    Assignee: The Regents of the University of California
    Inventors: John K. Bielicki, Jan Johansson
  • Patent number: 8415294
    Abstract: The present invention is directed to cyclodepsipeptide compounds having antineoplastic and/or antimicrobial activity, preferably Kitastatin 1. The present invention is further directed to methods of inhibiting cancer cell growth and/or microbial growth in a host inflicted therewith by administering cyclodepsipeptide compounds to the inflicted host.
    Type: Grant
    Filed: June 5, 2008
    Date of Patent: April 9, 2013
    Assignee: Arizona Board of Regents
    Inventors: George R. Pettit, Rui Tan, Robin K. Pettit
  • Patent number: 8415295
    Abstract: Dipeptidyl peptidase IV (DPP-IV)-inhibiting compounds are provided that have formula I: wherein n is 1 to 3; X is CH2; S; O; CF2 or C(CH3)2; Z is H; halogen; hydroxyl; (C1-6)alkoxy; (C1-12)alkyl; (C3-12)cycloalkyl; phenyl; or heteroaryl; where the phenyl and heteroaryl groups are optionally mono- or independently plurisubstituted with R7; optionally, X together with an adjacent ring carbon and Z form a fused cyclopropyl; and optionally, one of the bonds in the ring containing X is a double bond; and CriRii, R1, R1, R3, R4 and R5 are as described herein. Methods for preparing these compounds, and methods for treating diabetes, especially Type II diabetes, and other related diseases are described using the compounds of formula I in pharmaceutical compositions which contain these compounds. Pharmaceutical compositions which contain combinations of these compounds with other antidiabetic agents are also described herein.
    Type: Grant
    Filed: January 22, 2010
    Date of Patent: April 9, 2013
    Assignee: Phenomix Corporation
    Inventors: David Alan Campbell, David T. Winn, Juan Manuel Betancort
  • Patent number: 8415296
    Abstract: The present invention provides Oxyntomodulin peptide analogues useful in the treatment of diabetes and/or obesity.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: April 9, 2013
    Assignee: Eli Lilly and Company
    Inventors: Jorge Alsina-Fernandez, Wayne David Kohn
  • Patent number: 8415297
    Abstract: The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: April 9, 2013
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Tesfaye Biftu, Ann E. Weber
  • Patent number: 8415298
    Abstract: The present invention provides methods for diagnosing mental disorders. The invention also provides methods of identifying modulators of mental disorders as well as methods of using these modulators to treat patients suffering from mental disorders.
    Type: Grant
    Filed: June 21, 2005
    Date of Patent: April 9, 2013
    Assignee: The Board of Trustees of the Leland Stanford Junior University of Stanford
    Inventors: Huda Akil, William E. Bunney, Jr., Prabhakara V. Choudary, Simon J. Evans, Edward G. Jones, Jun Li, Juan F. Lopez, David M. Lyons, Margherita Molnar, Richard M. Myers, Alan F. Schatzberg, Richard Stein, Robert C. Thompson, Hiroaki Tomita, Marquis P. Vawter, Stanley J. Watson
  • Patent number: 8415299
    Abstract: A method is disclosed which is useful for elevating blood thyroid hormone levels in avian species (especially poultry species such as chickens, turkeys, ducks, quail, etc.) by implantation, injection, or supplementation of feed or water with thyroid hormones or thyroid-active substances (e.g., L-thyroxine, triiodothyronine, defatted and dessicated thyroid) to induce molting in order to extend egg production.
    Type: Grant
    Filed: July 7, 2005
    Date of Patent: April 9, 2013
    Inventors: Danny Michael Hooge, Robert Frederick Wideman, Jr., Wayne John Kuenzel
  • Patent number: 8415300
    Abstract: A fluid, milky microcrystalline aqueous suspension of a peptide or peptidomimetic and a counter-ion of a strong proton donor in water, wherein the peptide or peptidomimetic and counter-ion are present in amounts and at a molar ratio sufficient to form the suspension upon mixing and without formation of a gel. Also, lyophilized compositions that include a dried suspension, methods of making the lyophilized composition, methods of preparing the suspension, and sustained release formulations prepared by the methods.
    Type: Grant
    Filed: September 1, 2011
    Date of Patent: April 9, 2013
    Assignee: Medical Research Council Technology
    Inventors: Romano Deghenghi, Francois Boutignon
  • Patent number: 8415301
    Abstract: The disclosure pertains to methods of reducing decompensation through acute intervention including in subjects afflicted with acute decompensated heart failure. Particularly, the disclosure provides methods for treating acute cardiac decompensation by administering a pharmaceutically effective amount of relaxin.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: April 9, 2013
    Assignee: Corthera, Inc.
    Inventors: Elaine Unemori, Sam L Teichman, Gad Cotter, Dennis R Stewart, Martha J Whitehouse
  • Patent number: 8415302
    Abstract: The present invention relates to the clinical application of BBP, alone or in combination with other growth factors, for use in bone healing applications, such as spinal surgery. Additional applications include use in orthopedic implantable prostheses and implantation into other surgical sites (e.g., surgical reconstruction, regional osteopenia, etc.) where bone is desired.
    Type: Grant
    Filed: December 26, 2007
    Date of Patent: April 9, 2013
    Assignees: The Regents of the University of California, The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Samuel S. Murray, Elsa J. Brochmann-Murray, Keyvan Behnam, Jeffrey C. Wang
  • Patent number: 8415303
    Abstract: The present invention relates to nucleotide sequences of vertebrate Delta genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In a specific embodiment, the vertebrate Delta protein is a human protein. The invention further relates to fragments (and derivatives and analogs thereof) of Delta which comprise one or more domains of the Delta protein, including but not limited to the intracellular domain, extracellular domain, DSL domain, domain amino-terminal to the DSL domain, transmembrane region, or one or more EGF-like repeats of a Delta protein, or any combination of the foregoing. Antibodies to Delta, its derivatives and analogs, are additionally provided. Methods of production of the Delta proteins, derivatives and analogs, e.g., by recombinant means, are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are provided.
    Type: Grant
    Filed: October 10, 2006
    Date of Patent: April 9, 2013
    Assignees: Imperial Cancer Research Technology, Ltd., Yale University
    Inventors: David Ish-Horowicz, Domingos Manuel Pinto Henrique, Julian Hart Lewis, Spyridon Artavanis-Tsakonas, Grace E. Gray
  • Patent number: 8415304
    Abstract: The invention provides methods for predicting or determining the response of a mammalian tumor to a chemotherapeutic agent and for treating a mammalian tumor comprising detecting and quantifying the SPARC protein or RNA in a sample isolated from the mammal. The invention further provides kit for predicting the response of a mammalian tumor to a chemotherapeutic agent, comprising a means for the isolation of protein or RNA from the tumor, a SPARC protein or RNA detection and quantification means, control RNAs, and rules for predicting the response of the tumor based on the level of SPARC protein or RNA in tumor.
    Type: Grant
    Filed: March 29, 2007
    Date of Patent: April 9, 2013
    Assignee: Abraxis BioScience, LLC
    Inventors: Vuong Trieu, Neil P. Desai, Patrick Soon-Shiong
  • Patent number: 8415305
    Abstract: The present application relates to cyclic depsipeptides of Formula I: or derivatives thereof, wherein X, A1, A2, A3, A4, A5, A6 and A7 are defined herein. The cyclic depsipeptides of Formula I are inhibitors of kallikrein 7 and thus can be employed for the treatment of kallikrein-7 dependent diseases.
    Type: Grant
    Filed: August 14, 2008
    Date of Patent: April 9, 2013
    Assignee: Novartis AG
    Inventors: Philipp Krastel, Brigitta-Maria Liechty, Esther Schmitt, Erwin Paul Schreiner
  • Patent number: 8415306
    Abstract: The present invention relates to insulin-like growth factor 1 receptor binding peptides, polynucleotides encoding them, and methods of making and using the foregoing.
    Type: Grant
    Filed: May 25, 2011
    Date of Patent: April 9, 2013
    Assignee: Janssen Biotech, Inc.
    Inventors: Michael Diem, Karyn O'Neil