Patents Issued in March 4, 2014
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Patent number: 8663588Abstract: A double-layer three-way catalyst for purification of the exhaust gases from internal combustion engines which has excellent activity and thermal stability is described. The catalyst contains active aluminum oxide and a first cerium/zirconium mixed oxide which are both catalytically activated with palladium in the first layer applied to a catalyst support. In the second layer which is in direct contact with the exhaust gas, the catalyst likewise contains an active aluminum oxide and a second cerium/zirconium mixed oxide which are both catalytically activated with rhodium. The second cerium/zirconium mixed oxide has a higher zirconium oxide content than the first mixed oxide.Type: GrantFiled: June 27, 2007Date of Patent: March 4, 2014Assignee: Umicore AG & Co. KGInventors: Dieter Lindner, Martin Roesch, Raoul Klingmann, Anke Wolf, Joerg-Michael Richter
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Patent number: 8663589Abstract: The invention relates to a method for recovering sulphur from a sour gas containing hydrogen sulphide and carbon dioxide, comprising: oxidation of the sour gas, wherein a part of the hydrogen sulphide is oxidized to sulphur dioxide and water, reaction of the resulting sulphur dioxide with the residual hydrogen sulphide to elementary sulphur, and removal of elementary sulphur. According to the invention carbon dioxide and/or carbon dioxide generated by oxidation of the sour gas is compressed, and at least a part of the carbon dioxide is injected into an oil well. Furthermore, the invention relates to a plant suitable for performing the above method.Type: GrantFiled: September 20, 2012Date of Patent: March 4, 2014Assignee: Linde AktiengesellschaftInventor: Stephen Rhys Graville
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Patent number: 8663590Abstract: To provide a method for producing a carbonate, including: growing seed crystals, wherein the seed crystals are grown in a reaction solution containing at least urea. An aspect in which the seed crystals are strontium carbonate particles, an aspect in which the reaction solution contains a metal ion source and the metal ion source is a hydroxide of strontium, and the like are favorable.Type: GrantFiled: April 1, 2008Date of Patent: March 4, 2014Assignee: FUJIFILM CorporationInventor: Tetsuo Kawano
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Patent number: 8663591Abstract: Provided are a method of preparing a graphene shell and a graphene shell prepared using the method. A first heat treatment is performed on a mixture of an organic solvent and a graphitization catalyst so as to carburize the graphitization catalyst with carbon decomposed from the organic solvent. The graphitization catalyst is in the form of particles. A second heat treatment process is performed on the carburized graphitization catalyst in an inert or reductive gas atmosphere to thereby form graphene shells on surfaces of the carburized graphitization catalyst.Type: GrantFiled: June 2, 2008Date of Patent: March 4, 2014Assignee: Samsung Electronics Co., Ltd.Inventors: Seon-mi Yoon, Jae-young Choi, Hyeon-Jin Shin
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Patent number: 8663592Abstract: For implementing startup and priming phases of a vegetable carbon production method, an installation includes a generator of hot gases with low oxygen content, and a fan downstream which boosts the hot gases into a lower part of a reactor. The reactor includes a column of substantial height whose upper inlet, with a temperature T3 of less than 65° C., is used to continuously load and add biomass and whose lower part has a grid for support and removal of the load, an underlying injection chamber for the gases from the generator, and a mechanism for retrieving processed substances. The installation also includes, at the outlet for cold gases at temperature T3 at the top of the reactor column, a thermal post-combustion chamber for the extracted gases, a heat exchanger, a fan, a second heat exchanger, a vent and connecting pipes.Type: GrantFiled: February 29, 2008Date of Patent: March 4, 2014Assignee: Areva RenouvelablesInventor: David Mateos
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Patent number: 8663593Abstract: There is provided a method for fabricating a three dimensional graphene structure using a catalyst template, in which the three dimensional graphene structure in various forms can be obtained through a simple process by using a metal catalyst in various forms as a template and growing graphene thereon. There is also provided a method for controlling length of a three dimensional graphene structure to be from a few nanometers to a few millimeters by controlling length of the metal catalyst template.Type: GrantFiled: November 17, 2011Date of Patent: March 4, 2014Assignee: Research and Business Foundation Sungyunkwan UniversityInventors: Jibeom Yoo, Shashikant P. Patole, Hyunmyoung Lee
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Patent number: 8663594Abstract: An exhaust gas treating method removes sulfur dioxide from exhaust gas containing at least sulfur dioxide and mercury by bringing the exhaust gas into contact with absorption liquid. Persulfate is added into the absorption liquid or alternatively, iodine gas is added to the exhaust gas before the exhaust gas is brought into contact with the absorption liquid. A high removal rate for both sulfur dioxide and mercury is stably maintained if the load of power generation and the composition of exhaust gas fluctuate.Type: GrantFiled: March 5, 2008Date of Patent: March 4, 2014Assignee: Chiyoda CorporationInventors: Kazushige Kawamura, Dai Takeda, Eiji Awai, Akira Kumagai
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Patent number: 8663595Abstract: In one embodiment, the invention is to a process for purifying a by-product stream. The process comprises the step of providing a by-product stream comprising an ammonium salt, dimerized amide, and optionally water. The process further comprises the step of precipitating at least a portion of the dimerized amide in the by-product stream to form solid dimerized amide. The process further comprises the step of separating the solid dimerized amide from the by-product stream to form a treated by-product stream comprising less than 1 wt. % solid dimerized amide.Type: GrantFiled: December 21, 2011Date of Patent: March 4, 2014Assignee: Celanese International CorporationInventors: Stephan Brietzke, Peter Groer, Christoph Mollenkopf, Michael J. Bayer
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Patent number: 8663596Abstract: Disclosed is a reactor, a structured packing, and a method for increasing the rate of decomposition of polysulfides and oxidation of polysulfides and hydrogen sulfide in liquid sulfur. The reactor, the structured packing, and the method involve a structured packing for contacting a first stream and a second stream in a reactor including a catalyst. The catalyst increases the rate of decomposition of polysulfides and oxidation of polysulfides and hydrogen sulfide in the liquid sulfur of the first stream with the second stream. The first stream includes liquid sulfur containing polysulfides and dissolved hydrogen sulfide. The second stream includes an oxygen-containing gas.Type: GrantFiled: January 25, 2010Date of Patent: March 4, 2014Assignee: Fluor Enterprises, Inc.Inventors: Diwakar Garg, Xianming Jimmy Li, Uday Navin Parekh, Jung Soo Choe, Elmo Nasato
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Patent number: 8663597Abstract: The present invention relates to a method of obtaining 68Ga from a 68Ge/68Ga radioisotope generator and a method of preparing 68Ga-radiolabelled complexes using the obtained 68Ga. The method comprises elution of the generator with an aqueous chloride ion solution. The invention further relates to an apparatus for carrying out the 68Ga metal complex formation.Type: GrantFiled: September 21, 2010Date of Patent: March 4, 2014Assignees: GE Healthcare Limited, Hammersmith Imanet LimitedInventors: Johan Ulin, Bengt Langstrom, Irina Velikyan
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Patent number: 8663598Abstract: One embodiment of the disclosure provides an amino sequence of an anti-human transferrin receptor antibody, including: an amino sequence of a heavy chain variable region which is represented by SEQ ID NO.: 1 or SEQ ID NO.: 2, wherein the anti-human transferrin receptor antibody is capable of specifically binding to a human transferrin receptor.Type: GrantFiled: September 11, 2012Date of Patent: March 4, 2014Assignee: Industrial Technology Research InstituteInventors: Ming-Hua Yang, Min-Yuan Chou, Hsiang-Ching Wang
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Patent number: 8663599Abstract: The invention discloses a pharmaceutical composition of pH-sensitive liposome nanoparticles for lodging in a target tissue cell in situ of an animal subject, the nanoparticles comprising a proton-releasing photosensitive compound that releases protons upon photolysis, wherein the compound is in vesicles of the liposomes. A light or UV light is provided to induce the photosensitive compound to release the protons, thus the released protons causing the pH-sensitive liposome to decompose.Type: GrantFiled: November 21, 2012Date of Patent: March 4, 2014Assignees: GP Medical, Inc., National Tsing Hua UniversityInventors: Hsing-Wen Sung, Zi-Xian Liao, Min-Fan Chung, Ko-Jie Chen, Po-Yuan Cheng, Hosheng Tu
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Patent number: 8663600Abstract: Methods for diagnosing prostate cancer, and differentiate prostate cancer from other prostate complications, and use of said method, and diagnosing and monitoring lymph gland metastasis, post operative examinations, and examinations during or after radiation, cytostatic, and androgen treatments are disclosed. The methods comprise injecting tracer-labelled PSA or hK2 specific antibodies, visualising PSA or hK2 producing tissue with the aid of a visualization method, and diagnosing prostate cancer from the difference in visualization.Type: GrantFiled: February 17, 2005Date of Patent: March 4, 2014Assignee: Diaprost ABInventor: David Ulmert
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Patent number: 8663602Abstract: The invention enables high-throughput screening of compounds in living systems to detect unanticipated or unintended biological actions. The invention also allows for screening, detection, and confirmation of new indications for approved drugs. Screening and detection of toxic effects of compounds also can be achieved by using the methods of the invention. The methods comprise administering isotope-labeled substrates to a living system so that the label is incorporated into molecules in a manner that reveals flux rates through metabolic pathways thought to be involved in a disease. Comparisons between living systems exposed to compounds and living systems not so exposed reveals the effects of the compounds on the flux rates through the metabolic pathways. Combinations or mixtures of compounds can be systematically screened to detect unanticipated or unintended biological actions, including synergistic actions, in the same manner.Type: GrantFiled: February 18, 2011Date of Patent: March 4, 2014Assignee: The Regents of the University of CaliforniaInventor: Marc K. Hellerstein
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Patent number: 8663603Abstract: The invention provides compositions and methods for therapeutic and diagnostic applications.Type: GrantFiled: September 23, 2010Date of Patent: March 4, 2014Assignees: Bracco Suisse SA, Dyax Corp.Inventors: Christophe Arbogast, Philippe Bussat, Hong Fan, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Adrian D. Nunn, Radhakrishna K. Pillai, Sibylle Pochon, Kondareddiar Ramalingam, Ajay Shrivastava, Bo Song, Rolf E. Swenson, Mathew A. Von Wronski, Feng Yan, Aaron K. Sato, Sharon Michele Walker, Daniel T. Dransfield
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Patent number: 8663604Abstract: A method is provided for in vivo detection of a biochemical substance in an animal by culturing neurofluocytes that stably express a receptor of the biochemical substances by transfecting cells with cDNA of the receptor and a tag that will emit a detectable energy in the presence of the biochemical substance, implanting the neurofluocyte into the animal's brain; and detecting the energy emission of the tag. In a first embodiment, the biochemical substance is a neurotransmitter, the tag is a fluophore, and the step of detecting includes forming an opening in the animal's skull and optically detecting fluorescent emissions using a two-photon laser scanning microscope. Multiple biochemical substances can be simultaneously detected by culturing neurofluocytes that express different receptors and have different fluophor tags that produce fluorescent signals at distinguishable wavelengths.Type: GrantFiled: September 4, 2008Date of Patent: March 4, 2014Assignee: The Regents of the University of CaliforniaInventors: Quoc-Thang Nguyen, David Kleinfeld, Lee F. Schroeder
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Patent number: 8663605Abstract: Agent for treating fibers containing keratin, in particular human hair, having in a cosmetically acceptable carrier, (a) at least one amphiphilic, cationic polymer comprising at least one structural unit of formulae (I) to (IV), wherein R1 and R4 are independently hydrogen or a methyl group; X1 and X2 are independently oxygen or a NH group; A1 and A2 are independently ethane-1,2-diyl, propane-1,3-diyl or butane-1,4-diyl; R2, R3, R5 and R6 are independently a (C1 to C4)-alkyl group; R7 is a (C8 to C30)-alkyl group; (b) at least one other film-forming cationic and/or stabilizing cationic polymer; and (c) at least one film-forming non-ionic and/or stabilizing non-ionic polymer. The invention also relates to the use of the agent for temporarily styling hair and for haircare, particularly as an aerosol hairspray or aerosol mousse.Type: GrantFiled: February 15, 2011Date of Patent: March 4, 2014Assignee: Henkel AG & Co. KGaAInventors: Pamela Kaftan, Burkhard Mueller
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Patent number: 8663606Abstract: A method for producing a cationic liposomal preparation comprising a lipophilic active compound with physical and chemical stability during manufacturing, storing and reconstituting, and further a cationic liposomal preparation obtainable by this method as well as specific cationic liposomal preparations as well as pharmaceutical compositions are disclosed.Type: GrantFiled: October 21, 2011Date of Patent: March 4, 2014Assignee: Medigene AGInventors: Carsten Mundus, Christian Welz, Oliver Schramel, Heinrich Haas, Thomas Fichert, Brita Schulze, Toralf Peymann, Uwe Michaelis, Michael Teifel, Friedrich Gruber, Gerhard Winter
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Patent number: 8663607Abstract: Compositions containing ferrate(VI) are disclosed. Also, methods are disclosed that utilize ferrate(VI).Type: GrantFiled: March 10, 2008Date of Patent: March 4, 2014Assignee: Battelle Memorial InstituteInventors: Bruce F. Monzyk, Michael J. Murphy, Chad Cucksey, F. Michael von Fahnestock, Andrew J. Savage, David N. Clark
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Patent number: 8663608Abstract: A hydroxytyrosol polymer formed by either C—C coupling or C—O—C coupling is provided. Preferred polymers are formed by C—C coupling and the dimer has the following structure: Compounds of the invention have been found to have antioxidant properties and their use in antioxidant compositions forms a further aspect of the invention.Type: GrantFiled: September 22, 2010Date of Patent: March 4, 2014Assignee: University of Cape TownInventors: Stephanie Gail Burton, Lester Merlin Davids
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Patent number: 8663609Abstract: The invention relates to a composition comprising a oil-soluble polar modified polymer, a sugar silicone surfactant and a hyperbranched polyol.Type: GrantFiled: June 29, 2010Date of Patent: March 4, 2014Assignee: L'OrealInventors: Hy Si Bui, Mohamed Kanji, Chunhua Li, Anita Chon Tong, Susan Halpern, Bruno Bavouzet
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Patent number: 8663610Abstract: A method of producing an anhydrous antiperspirant composition comprising (a) providing a mixture of at least one antiperspirant active including a metal salt, and an anhydrous carrier for the at least one antiperspirant active in which the at least one antiperspirant active is dissolved, the carrier comprising a eutectic mixture of at least one basic compound selected from a basic amide and a basic amine and at least one member chosen from a cation and zwitterion; and (b) heating the mixture to form a stabilized eutectic system of the at least one antiperspirant active and the anhydrous carrier. Also, an anhydrous antiperspirant composition.Type: GrantFiled: December 16, 2010Date of Patent: March 4, 2014Assignee: Colgate-Palmolive CompanyInventors: Iraklis Pappas, Michael C. Fitzgerald, Long Pan
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Patent number: 8663611Abstract: The present disclosure is directed to a cosmetic composition for controlling perspiration and odor. Despite being free of volatile silicones—which have garnered a bad reputation due to their ecotoxicity and bioaccumulability in aquatic species—the composition of the instant disclosure replicates the textural and sensorial benefits provided by the use of volatile silicones like cyclotetrasiloxane, cyclopentasiloxane and cyclohexasiloxane.Type: GrantFiled: June 8, 2012Date of Patent: March 4, 2014Assignee: L'Oreal S.A.Inventors: Ethan Alden-Danforth, William Feuer, Nancy Williams
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Patent number: 8663612Abstract: Novel ampholytic ter-polymers comprising at least an ethylenically unsaturated cationic monomer, a monomer containing a carboxylic acid or sulfonic acid group and diallyamine or derivative are claimed. Further, the ter-polymers may be used in personal care or personal washing compositions optionally in the presence of conditioning agents such as silicone, fatty amines, fatty amine oxides and fatty quaternaries and/or various benefit agents. The ter-polymer compositions are especially useful in the treatment of keratin-containing substrates. Keratin substrates include, but are not limited to, animal and human hair, skin and nails.Type: GrantFiled: February 24, 2010Date of Patent: March 4, 2014Assignee: BASF SEInventors: Manuel Gamez-Garcia, Xian-Zhi Zhou
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Patent number: 8663613Abstract: Disclosed are hair or skin conditioning compositions comprising by weight: (a) from about 0.1% to about 10% of a thickening polymer system; (b) from about 0.1% to about 8.0% of a surfactant system selected from the group consisting of cationic surfactant, nonionic surfactant, and mixtures thereof; (c) from about 0.1% to about 10% of a hydrophobically modified amido silicone copolyol; and (d) an aqueous carrier; wherein the composition has a transmittance of 25% or more and/or wherein the composition has a viscosity of from about 1,000 cps to about 50,000 cps and Shear Thinning Index of 30 or more. The compositions are especially suitable for hair care products such as hair conditioning products for rinse-off/leave-on use.Type: GrantFiled: March 22, 2013Date of Patent: March 4, 2014Assignee: The Procter & Gamble CompanyInventors: Nobuaki Uehara, Satomi Asari, Natsumi Komure
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Patent number: 8663614Abstract: The present invention relates to a method of shaving the skin, in particular the facial skin of men, using a composition comprising, in a cosmetically acceptable medium, at least one salicylic acid derivative of formula in which: R represents a linear, branched or cyclic, saturated aliphatic chain containing from 3 to 11 carbon atoms; an unsaturated aliphatic chain containing from 3 to 17 carbon atoms bearing one or more conjugated or nonconjugated double bonds; an aromatic nucleus linked to the carbonyl radical directly or by means of saturated or unsaturated aliphatic chains containing from 2 to 7 carbon atoms; it being possible for said R groups to be substituted with one or more substituents, which may be identical or different, chosen from halogen atoms, a trifluoromethyl group, a hydroxyl group in free form or in a form esterified with an acid containing from 1 to 6 carbon atoms or else with a carboxyl function, which is free or esterified with a C1-C6 alcohol; R? represents a hydroxyl group or anType: GrantFiled: October 7, 2009Date of Patent: March 4, 2014Assignee: L'OrealInventor: Lionel Aubert
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Patent number: 8663615Abstract: The present invention comprises a bio-polymer based solid for the sustained release of an active agent into the air consisting of: a) a primary starched—based polymer; b) a secondary polyether block amide polymer, and: c) a filler component. d) one or more active oils The active oils can be one or more fragrances so as to provide an air freshening composition, a flavor to create a certain aromatic environment or a repellant such as insect repellants for the elimination of mosquitoes and the like. Animal repellants may be incorporated to ward off unwanted pets and wildlife outside the home and attractants may also be utilized in the production of fishing lures and the like.Type: GrantFiled: August 17, 2011Date of Patent: March 4, 2014Inventors: Paul Joseph Albee, Jr., Eric Matthew Albee, Sandra Albee Keeley
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Patent number: 8663616Abstract: Disclosed herein are compositions and methods to treat an oral cavity surface with a peracid-based benefit agent. The peracid benefit agent can be use for oral surface bleaching, whitening, disinfecting, destaining, deodorizing, decreasing or removing biofilm, and combinations thereof. The peracid is enzymatically generated from a carboxylic acid ester substrate using a CE-7 carbohydrate esterase having perhydrolytic activity (perhydrolase) in the presence of a source of peroxygen. A fusion protein comprising the perhydrolase coupled to a peptidic component having affinity for an oral cavity surface, either directly or through an optional linker, may be used to target the perhydrolytic activity to the oral cavity surface.Type: GrantFiled: December 19, 2011Date of Patent: March 4, 2014Assignee: E I du Pont de Nemours and CompanyInventors: Lisa A. Butterick, Scott D. Cunningham, Robert DiCosimo, Kari A. Fosser, Tanja Maria Gruber, Sharon L. Haynie, Mark S. Payne, Pierre E. Rouviere, Hong Wang
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Patent number: 8663617Abstract: The current invention relates to methods and compositions for the treatment of wounds in a mammalian subject. Particularly, the invention relates to novel polypeptides and encoding nucleic acids that stimulate keratinocyte and endothelial cell motility and/or proliferation.Type: GrantFiled: October 16, 2012Date of Patent: March 4, 2014Assignee: Tufts UniversityInventor: Ira M Herman
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Patent number: 8663618Abstract: A process for surface modification of polymer that enhances cell growth as well as inhibits growth of microorganisms is disclosed.Type: GrantFiled: March 9, 2011Date of Patent: March 4, 2014Assignee: Council of Scientific & Industrial ResearchInventors: Prasad L. V. Bhagavatula, Virginia D. Britto
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Patent number: 8663619Abstract: Provided herein are uses of murgantiol for attracting stink bugs in indoor settings. Stink bug traps comprising murgantiol and methods of using murgantiol in traps indoors are provided. Compositions comprising murgantiol are also described.Type: GrantFiled: July 11, 2011Date of Patent: March 4, 2014Assignee: Sterling International Inc.Inventors: Qing-He Zhang, Rodney G. Schneidmiller, Guiji Zhou, Doreen R. Hoover
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Patent number: 8663620Abstract: Provided herein are uses of the Harlequin bug pheromone, murgantiol, alone or in a synergistic combination with at least one other stink bug attractant, such as methyl (2E,4E,6Z)-decatrienoate or methyl (2E,4Z)-decadienoate, or both, for attracting stink bugs such as the brown marmorated stink bug in outdoor settings. Stink bug traps comprising murgantiol, or synergistic compositions comprising murgantiol with at least one other stink bug attractant, and methods of using these compositions in traps outdoors are provided. Compositions comprising murgantiol are also described as synergistic combinations of murgantiol with at least one other stink bug attractant.Type: GrantFiled: March 1, 2012Date of Patent: March 4, 2014Assignee: Sterling International Inc.Inventors: Qing-He Zhang, Rodney G. Schneidmiller, Guiji Zhou, Doreen R. Hoover
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Patent number: 8663621Abstract: An unsaturated hydroxyl-ester pheromone for the neotropical root weevil Diaprepes abbreviatus has been isolated, identified and synthesized. It is useful for trapping the weevil to reduce or prevent damage to plants.Type: GrantFiled: January 18, 2013Date of Patent: March 4, 2014Assignee: The United States of America, as represented by The Secretary of AgricultureInventors: Stephen L Lapointe, Ashot Khrimian, Joseph C Dickens, Peter Edmund Alan Teal, Fatma Kaplan
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Patent number: 8663622Abstract: The invention is directed to compositions capable of augmenting the immunogenicity of a vaccine. The composition, or adjuvant, is administered to a mammal in need thereof in sequential or concurrent combination with a vaccine antigen. In one preferred aspect, the adjuvant is provided in the form of a recombinant poxvirus vector, such as a vaccinia virus vector, which comprises a nucleic acid sequence encoding IL-15.Type: GrantFiled: December 15, 2003Date of Patent: March 4, 2014Assignee: The United States of America, as represented by the Secretary, Department of Health & Human ServicesInventors: Liyanage P. Perera, Thomas A. Waldmann, Sang-Kon Oh, Jay A. Berzofsky
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Patent number: 8663623Abstract: The present invention relates to multi purpose herbal cattle feed supplement compositions for enhancing the productivity and quality of milk by improved bioavailability/bioenhancing of nutrients. The herbal composition comprises an effective amount of an extract and/or at least one bioactive fraction or powder from herbs such as Asparagus, Withania, Lepidium, Bacopa, Nardostachys, Vetiveria, Pueraria, Emblica, Tinospora etc.; one or more additive selected from Probiotics, decorticated cotton seed extract (DCC), chelated mineral mixture, mineral nutrients, dicalcium phosphate (DCP), dolomite, calcite, vitamins and amino acids to obtain the herbal feed supplement compositions.Type: GrantFiled: October 12, 2009Date of Patent: March 4, 2014Inventor: Prashant Neminath Patil
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Patent number: 8663624Abstract: The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.Type: GrantFiled: October 5, 2011Date of Patent: March 4, 2014Assignee: The Regents of the University of CaliforniaInventors: David V. Schaffer, Ryan R. Klimczak, James T. Koerber, John G. Flannery
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Patent number: 8663625Abstract: The present invention relates to a monolithic biomaterial. The monolithic biomaterial has a primary network of convective flow, microfluidic channels that are embedded in a substrate, where the substrate is diffusively permeable to aqueous solutes. The present invention also relates to a method of making the monolithic biomaterial, as well as methods of using the monolithic biomaterial to facilitate healing of a cutaneous wound of a mammalian subject and of regulating cells.Type: GrantFiled: October 17, 2005Date of Patent: March 4, 2014Assignee: Cornell Research FoundationInventors: Abraham D. Stroock, Mario Cabodi, Lawrence Bonassar
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Patent number: 8663626Abstract: An isolated composition of matter is provided comprising a heterogeneous population of cells seeded on a surface of a scaffold, wherein the heterogeneous population of cells comprises at least one pancreatic islet, endothelial cells and fibroblast cells. Methods of generating same and uses thereof are also provided.Type: GrantFiled: March 12, 2008Date of Patent: March 4, 2014Assignee: Technion Research & Development Foundation LimitedInventors: Shulamit Levenberg, Keren Francis
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Patent number: 8663627Abstract: Methods, compositions, and kits for repairing damaged myocardium and/or myocardial cells including the administration cytokines are disclosed and claimed. Methods and compositions for the development of large arteries and vessels are also disclosed and claimed. The present application also discloses and claims methods and media for the growth, expansion, and activation of human cardiac stem cells.Type: GrantFiled: October 27, 2010Date of Patent: March 4, 2014Assignee: New York Medical CollegeInventor: Piero Anversa
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Patent number: 8663628Abstract: An enzymatic solid phase reaction for preparing a solid having greater than 40% monoglyceride from a reaction mixture; wherein the reaction mixture comprises: (i) lipase; (ii) at least 14 weight % glycerol; and (iii) glyceride; and optionally (iv) lecithin; such that if (iv) is not present then the glyceride (iii) has an iodine value of between about 5 and about 35, and a solid fat content of more than about 75% at 20° C. The present invention further relates to a process of preparing an enzymatic solid phase reaction mixture for preparing a solid having greater than 40% monoglyceride.Type: GrantFiled: May 30, 2008Date of Patent: March 4, 2014Assignee: Dupont Nutrition Biosciences APSInventor: Jorn B. Soe
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Patent number: 8663629Abstract: This invention provides: novel protein homologous of a Kunitz domain, which are capable of binding kallikrein; polynucleotides that encode such novel proteins; and vectors and transformed host cells containing these polynucleotides.Type: GrantFiled: August 9, 2012Date of Patent: March 4, 2014Assignee: Dyax Corp.Inventors: William Markland, Robert C. Ladner
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Patent number: 8663630Abstract: The molecular mechanisms of peroxisome biogenesis have begun to emerge; in contrast, relatively little is known about how the organelle functions as cells age. The present inventors characterized age-related changes in peroxisomes of human cells and showed that aging compromises peroxisomal targeting signal 1 (PTS1) protein import, with the critical antioxidant enzyme, catalase, especially affected. The number and appearance of peroxisomes are altered in these cells, and the organelles accumulate the PTS1-import receptor, Pex5p, on their membranes. Concomitantly, cells produce increasing amounts of the toxic metabolite, H2O2, and this increased load of reactive oxygen species (ROS) may further reduce peroxisomal protein import and exacerbate the effects of aging.Type: GrantFiled: September 29, 2009Date of Patent: March 4, 2014Assignee: Wayne State UniversityInventors: Stanley R. Terlecky, Paul A. Walton
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Patent number: 8663631Abstract: The present invention provides methods of treating LAL deficiency comprising administering to a mammal a therapeutically effective amount of lysosomal acid lipase with an effective dosage frequency. Methods of improving growth and liver function, increasing LAL tissue concentration, and increasing LAL activity in a human patient suffering from LAL deficiency are also provided.Type: GrantFiled: September 9, 2011Date of Patent: March 4, 2014Assignee: Synageva Biopharma CorporationInventor: Anthony Quinn
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Patent number: 8663632Abstract: Compositions and methods of treating cancer using a thiaminase compound are described. The presently-disclosed subject matter includes a method of treating cancer by administering a thiaminase compound and a thiamine-dependent enzyme inhibitor.Type: GrantFiled: October 14, 2011Date of Patent: March 4, 2014Assignee: University of Kentucky Research FoundationInventors: Jeffrey Moscow, Shuqian Liu, Younsoo Bae
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Patent number: 8663633Abstract: Methods for identifying modified proteases with modified substrate specificity or other properties are provided. The methods screen candidate and modified proteases by contacting them with a substrate, such as a serpin, an alpha macroglobulins or a p35 family protein or modified serpins and modified p35 family members or modified alpha macroglobulins, that, upon cleavage of the substrate, traps the protease by forming a stable complex. Also provided are modified proteases.Type: GrantFiled: July 2, 2012Date of Patent: March 4, 2014Assignees: Torrey Pines Institute for Molecular Studies, Catalyst Biosciences, Inc.Inventor: Edwin L. Madison
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Patent number: 8663634Abstract: The present invention provides methods of treating, preventing or ameliorating the symptoms of T cell-mediated immunological diseases, particularly autoimmune diseases, through the use of anti-CD3 antibodies. In particular, the methods of the invention provide for administration of antibodies that specifically bind the epsilon subunit within the human CD3 complex. Such antibodies modulate the T cell receptor/alloantigen interaction and, thus, regulate the T cell mediated cytotoxicity associated with autoimmune disorders. Additionally, the invention provides for modification of the anti-CD3 antibodies such that they exhibit reduced or eliminated effector function and T cell activation as compared to non-modified anti-CD3 antibodies.Type: GrantFiled: July 11, 2006Date of Patent: March 4, 2014Assignee: MacroGenics, Inc.Inventors: Scott Koenig, Ronald Wilder, Ezio Bonvini, Leslie S. Johnson
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Patent number: 8663635Abstract: The present invention provides methods of diagnosis, providing a prognosis and a therapeutic target for the treatment of cancers that express N-cadherin, including prostrate and bladder cancers.Type: GrantFiled: November 10, 2008Date of Patent: March 4, 2014Assignee: The Regents of the University of CaliforniaInventor: Robert E. Reiter
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Patent number: 8663636Abstract: The invention relates to targeted binding agents against DLL4 and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to DLL4. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of DLL4 and as diagnostics.Type: GrantFiled: April 13, 2012Date of Patent: March 4, 2014Assignee: MedImmune, LLCInventors: Ian Foltz, David Jenkins, Vahe Bedian
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Patent number: 8663637Abstract: The present invention relates to antibodies against specific domains of Olfml3 and the use of such in angiogenesis. In particular aspects, angiogenesis-related conditions, such as cancer, can be treated by the composition comprising the Olfml3 antagonists.Type: GrantFiled: July 25, 2012Date of Patent: March 4, 2014Assignee: Research Development FoundationInventors: Beat A. Imhof, Marijana Miljkovic-Licina, Philippe Hammel
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Patent number: 8663638Abstract: The invention describes the use of trifunctional bispecific and trispecific antibodies for destroying tumor cells which e.g. are disseminated intraperitoneally due to a surgical intervention, wherein the antibody is administered intraoperatively, preferably directly locally into the abdominal cavity.Type: GrantFiled: September 4, 2008Date of Patent: March 4, 2014Assignee: Trion Pharma GmbHInventors: Horst Lindhofer, Markus M. Heiss