Patents Issued in March 4, 2014
  • Patent number: 8663588
    Abstract: A double-layer three-way catalyst for purification of the exhaust gases from internal combustion engines which has excellent activity and thermal stability is described. The catalyst contains active aluminum oxide and a first cerium/zirconium mixed oxide which are both catalytically activated with palladium in the first layer applied to a catalyst support. In the second layer which is in direct contact with the exhaust gas, the catalyst likewise contains an active aluminum oxide and a second cerium/zirconium mixed oxide which are both catalytically activated with rhodium. The second cerium/zirconium mixed oxide has a higher zirconium oxide content than the first mixed oxide.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: March 4, 2014
    Assignee: Umicore AG & Co. KG
    Inventors: Dieter Lindner, Martin Roesch, Raoul Klingmann, Anke Wolf, Joerg-Michael Richter
  • Patent number: 8663589
    Abstract: The invention relates to a method for recovering sulphur from a sour gas containing hydrogen sulphide and carbon dioxide, comprising: oxidation of the sour gas, wherein a part of the hydrogen sulphide is oxidized to sulphur dioxide and water, reaction of the resulting sulphur dioxide with the residual hydrogen sulphide to elementary sulphur, and removal of elementary sulphur. According to the invention carbon dioxide and/or carbon dioxide generated by oxidation of the sour gas is compressed, and at least a part of the carbon dioxide is injected into an oil well. Furthermore, the invention relates to a plant suitable for performing the above method.
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: March 4, 2014
    Assignee: Linde Aktiengesellschaft
    Inventor: Stephen Rhys Graville
  • Patent number: 8663590
    Abstract: To provide a method for producing a carbonate, including: growing seed crystals, wherein the seed crystals are grown in a reaction solution containing at least urea. An aspect in which the seed crystals are strontium carbonate particles, an aspect in which the reaction solution contains a metal ion source and the metal ion source is a hydroxide of strontium, and the like are favorable.
    Type: Grant
    Filed: April 1, 2008
    Date of Patent: March 4, 2014
    Assignee: FUJIFILM Corporation
    Inventor: Tetsuo Kawano
  • Patent number: 8663591
    Abstract: Provided are a method of preparing a graphene shell and a graphene shell prepared using the method. A first heat treatment is performed on a mixture of an organic solvent and a graphitization catalyst so as to carburize the graphitization catalyst with carbon decomposed from the organic solvent. The graphitization catalyst is in the form of particles. A second heat treatment process is performed on the carburized graphitization catalyst in an inert or reductive gas atmosphere to thereby form graphene shells on surfaces of the carburized graphitization catalyst.
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: March 4, 2014
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Seon-mi Yoon, Jae-young Choi, Hyeon-Jin Shin
  • Patent number: 8663592
    Abstract: For implementing startup and priming phases of a vegetable carbon production method, an installation includes a generator of hot gases with low oxygen content, and a fan downstream which boosts the hot gases into a lower part of a reactor. The reactor includes a column of substantial height whose upper inlet, with a temperature T3 of less than 65° C., is used to continuously load and add biomass and whose lower part has a grid for support and removal of the load, an underlying injection chamber for the gases from the generator, and a mechanism for retrieving processed substances. The installation also includes, at the outlet for cold gases at temperature T3 at the top of the reactor column, a thermal post-combustion chamber for the extracted gases, a heat exchanger, a fan, a second heat exchanger, a vent and connecting pipes.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: March 4, 2014
    Assignee: Areva Renouvelables
    Inventor: David Mateos
  • Patent number: 8663593
    Abstract: There is provided a method for fabricating a three dimensional graphene structure using a catalyst template, in which the three dimensional graphene structure in various forms can be obtained through a simple process by using a metal catalyst in various forms as a template and growing graphene thereon. There is also provided a method for controlling length of a three dimensional graphene structure to be from a few nanometers to a few millimeters by controlling length of the metal catalyst template.
    Type: Grant
    Filed: November 17, 2011
    Date of Patent: March 4, 2014
    Assignee: Research and Business Foundation Sungyunkwan University
    Inventors: Jibeom Yoo, Shashikant P. Patole, Hyunmyoung Lee
  • Patent number: 8663594
    Abstract: An exhaust gas treating method removes sulfur dioxide from exhaust gas containing at least sulfur dioxide and mercury by bringing the exhaust gas into contact with absorption liquid. Persulfate is added into the absorption liquid or alternatively, iodine gas is added to the exhaust gas before the exhaust gas is brought into contact with the absorption liquid. A high removal rate for both sulfur dioxide and mercury is stably maintained if the load of power generation and the composition of exhaust gas fluctuate.
    Type: Grant
    Filed: March 5, 2008
    Date of Patent: March 4, 2014
    Assignee: Chiyoda Corporation
    Inventors: Kazushige Kawamura, Dai Takeda, Eiji Awai, Akira Kumagai
  • Patent number: 8663595
    Abstract: In one embodiment, the invention is to a process for purifying a by-product stream. The process comprises the step of providing a by-product stream comprising an ammonium salt, dimerized amide, and optionally water. The process further comprises the step of precipitating at least a portion of the dimerized amide in the by-product stream to form solid dimerized amide. The process further comprises the step of separating the solid dimerized amide from the by-product stream to form a treated by-product stream comprising less than 1 wt. % solid dimerized amide.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: March 4, 2014
    Assignee: Celanese International Corporation
    Inventors: Stephan Brietzke, Peter Groer, Christoph Mollenkopf, Michael J. Bayer
  • Patent number: 8663596
    Abstract: Disclosed is a reactor, a structured packing, and a method for increasing the rate of decomposition of polysulfides and oxidation of polysulfides and hydrogen sulfide in liquid sulfur. The reactor, the structured packing, and the method involve a structured packing for contacting a first stream and a second stream in a reactor including a catalyst. The catalyst increases the rate of decomposition of polysulfides and oxidation of polysulfides and hydrogen sulfide in the liquid sulfur of the first stream with the second stream. The first stream includes liquid sulfur containing polysulfides and dissolved hydrogen sulfide. The second stream includes an oxygen-containing gas.
    Type: Grant
    Filed: January 25, 2010
    Date of Patent: March 4, 2014
    Assignee: Fluor Enterprises, Inc.
    Inventors: Diwakar Garg, Xianming Jimmy Li, Uday Navin Parekh, Jung Soo Choe, Elmo Nasato
  • Patent number: 8663597
    Abstract: The present invention relates to a method of obtaining 68Ga from a 68Ge/68Ga radioisotope generator and a method of preparing 68Ga-radiolabelled complexes using the obtained 68Ga. The method comprises elution of the generator with an aqueous chloride ion solution. The invention further relates to an apparatus for carrying out the 68Ga metal complex formation.
    Type: Grant
    Filed: September 21, 2010
    Date of Patent: March 4, 2014
    Assignees: GE Healthcare Limited, Hammersmith Imanet Limited
    Inventors: Johan Ulin, Bengt Langstrom, Irina Velikyan
  • Patent number: 8663598
    Abstract: One embodiment of the disclosure provides an amino sequence of an anti-human transferrin receptor antibody, including: an amino sequence of a heavy chain variable region which is represented by SEQ ID NO.: 1 or SEQ ID NO.: 2, wherein the anti-human transferrin receptor antibody is capable of specifically binding to a human transferrin receptor.
    Type: Grant
    Filed: September 11, 2012
    Date of Patent: March 4, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Ming-Hua Yang, Min-Yuan Chou, Hsiang-Ching Wang
  • Patent number: 8663599
    Abstract: The invention discloses a pharmaceutical composition of pH-sensitive liposome nanoparticles for lodging in a target tissue cell in situ of an animal subject, the nanoparticles comprising a proton-releasing photosensitive compound that releases protons upon photolysis, wherein the compound is in vesicles of the liposomes. A light or UV light is provided to induce the photosensitive compound to release the protons, thus the released protons causing the pH-sensitive liposome to decompose.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: March 4, 2014
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Zi-Xian Liao, Min-Fan Chung, Ko-Jie Chen, Po-Yuan Cheng, Hosheng Tu
  • Patent number: 8663600
    Abstract: Methods for diagnosing prostate cancer, and differentiate prostate cancer from other prostate complications, and use of said method, and diagnosing and monitoring lymph gland metastasis, post operative examinations, and examinations during or after radiation, cytostatic, and androgen treatments are disclosed. The methods comprise injecting tracer-labelled PSA or hK2 specific antibodies, visualising PSA or hK2 producing tissue with the aid of a visualization method, and diagnosing prostate cancer from the difference in visualization.
    Type: Grant
    Filed: February 17, 2005
    Date of Patent: March 4, 2014
    Assignee: Diaprost AB
    Inventor: David Ulmert
  • Patent number: 8663602
    Abstract: The invention enables high-throughput screening of compounds in living systems to detect unanticipated or unintended biological actions. The invention also allows for screening, detection, and confirmation of new indications for approved drugs. Screening and detection of toxic effects of compounds also can be achieved by using the methods of the invention. The methods comprise administering isotope-labeled substrates to a living system so that the label is incorporated into molecules in a manner that reveals flux rates through metabolic pathways thought to be involved in a disease. Comparisons between living systems exposed to compounds and living systems not so exposed reveals the effects of the compounds on the flux rates through the metabolic pathways. Combinations or mixtures of compounds can be systematically screened to detect unanticipated or unintended biological actions, including synergistic actions, in the same manner.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: March 4, 2014
    Assignee: The Regents of the University of California
    Inventor: Marc K. Hellerstein
  • Patent number: 8663603
    Abstract: The invention provides compositions and methods for therapeutic and diagnostic applications.
    Type: Grant
    Filed: September 23, 2010
    Date of Patent: March 4, 2014
    Assignees: Bracco Suisse SA, Dyax Corp.
    Inventors: Christophe Arbogast, Philippe Bussat, Hong Fan, Karen E. Linder, Edmund R. Marinelli, Palaniappa Nanjappan, Adrian D. Nunn, Radhakrishna K. Pillai, Sibylle Pochon, Kondareddiar Ramalingam, Ajay Shrivastava, Bo Song, Rolf E. Swenson, Mathew A. Von Wronski, Feng Yan, Aaron K. Sato, Sharon Michele Walker, Daniel T. Dransfield
  • Patent number: 8663604
    Abstract: A method is provided for in vivo detection of a biochemical substance in an animal by culturing neurofluocytes that stably express a receptor of the biochemical substances by transfecting cells with cDNA of the receptor and a tag that will emit a detectable energy in the presence of the biochemical substance, implanting the neurofluocyte into the animal's brain; and detecting the energy emission of the tag. In a first embodiment, the biochemical substance is a neurotransmitter, the tag is a fluophore, and the step of detecting includes forming an opening in the animal's skull and optically detecting fluorescent emissions using a two-photon laser scanning microscope. Multiple biochemical substances can be simultaneously detected by culturing neurofluocytes that express different receptors and have different fluophor tags that produce fluorescent signals at distinguishable wavelengths.
    Type: Grant
    Filed: September 4, 2008
    Date of Patent: March 4, 2014
    Assignee: The Regents of the University of California
    Inventors: Quoc-Thang Nguyen, David Kleinfeld, Lee F. Schroeder
  • Patent number: 8663605
    Abstract: Agent for treating fibers containing keratin, in particular human hair, having in a cosmetically acceptable carrier, (a) at least one amphiphilic, cationic polymer comprising at least one structural unit of formulae (I) to (IV), wherein R1 and R4 are independently hydrogen or a methyl group; X1 and X2 are independently oxygen or a NH group; A1 and A2 are independently ethane-1,2-diyl, propane-1,3-diyl or butane-1,4-diyl; R2, R3, R5 and R6 are independently a (C1 to C4)-alkyl group; R7 is a (C8 to C30)-alkyl group; (b) at least one other film-forming cationic and/or stabilizing cationic polymer; and (c) at least one film-forming non-ionic and/or stabilizing non-ionic polymer. The invention also relates to the use of the agent for temporarily styling hair and for haircare, particularly as an aerosol hairspray or aerosol mousse.
    Type: Grant
    Filed: February 15, 2011
    Date of Patent: March 4, 2014
    Assignee: Henkel AG & Co. KGaA
    Inventors: Pamela Kaftan, Burkhard Mueller
  • Patent number: 8663606
    Abstract: A method for producing a cationic liposomal preparation comprising a lipophilic active compound with physical and chemical stability during manufacturing, storing and reconstituting, and further a cationic liposomal preparation obtainable by this method as well as specific cationic liposomal preparations as well as pharmaceutical compositions are disclosed.
    Type: Grant
    Filed: October 21, 2011
    Date of Patent: March 4, 2014
    Assignee: Medigene AG
    Inventors: Carsten Mundus, Christian Welz, Oliver Schramel, Heinrich Haas, Thomas Fichert, Brita Schulze, Toralf Peymann, Uwe Michaelis, Michael Teifel, Friedrich Gruber, Gerhard Winter
  • Patent number: 8663607
    Abstract: Compositions containing ferrate(VI) are disclosed. Also, methods are disclosed that utilize ferrate(VI).
    Type: Grant
    Filed: March 10, 2008
    Date of Patent: March 4, 2014
    Assignee: Battelle Memorial Institute
    Inventors: Bruce F. Monzyk, Michael J. Murphy, Chad Cucksey, F. Michael von Fahnestock, Andrew J. Savage, David N. Clark
  • Patent number: 8663608
    Abstract: A hydroxytyrosol polymer formed by either C—C coupling or C—O—C coupling is provided. Preferred polymers are formed by C—C coupling and the dimer has the following structure: Compounds of the invention have been found to have antioxidant properties and their use in antioxidant compositions forms a further aspect of the invention.
    Type: Grant
    Filed: September 22, 2010
    Date of Patent: March 4, 2014
    Assignee: University of Cape Town
    Inventors: Stephanie Gail Burton, Lester Merlin Davids
  • Patent number: 8663609
    Abstract: The invention relates to a composition comprising a oil-soluble polar modified polymer, a sugar silicone surfactant and a hyperbranched polyol.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: March 4, 2014
    Assignee: L'Oreal
    Inventors: Hy Si Bui, Mohamed Kanji, Chunhua Li, Anita Chon Tong, Susan Halpern, Bruno Bavouzet
  • Patent number: 8663610
    Abstract: A method of producing an anhydrous antiperspirant composition comprising (a) providing a mixture of at least one antiperspirant active including a metal salt, and an anhydrous carrier for the at least one antiperspirant active in which the at least one antiperspirant active is dissolved, the carrier comprising a eutectic mixture of at least one basic compound selected from a basic amide and a basic amine and at least one member chosen from a cation and zwitterion; and (b) heating the mixture to form a stabilized eutectic system of the at least one antiperspirant active and the anhydrous carrier. Also, an anhydrous antiperspirant composition.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: March 4, 2014
    Assignee: Colgate-Palmolive Company
    Inventors: Iraklis Pappas, Michael C. Fitzgerald, Long Pan
  • Patent number: 8663611
    Abstract: The present disclosure is directed to a cosmetic composition for controlling perspiration and odor. Despite being free of volatile silicones—which have garnered a bad reputation due to their ecotoxicity and bioaccumulability in aquatic species—the composition of the instant disclosure replicates the textural and sensorial benefits provided by the use of volatile silicones like cyclotetrasiloxane, cyclopentasiloxane and cyclohexasiloxane.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: March 4, 2014
    Assignee: L'Oreal S.A.
    Inventors: Ethan Alden-Danforth, William Feuer, Nancy Williams
  • Patent number: 8663612
    Abstract: Novel ampholytic ter-polymers comprising at least an ethylenically unsaturated cationic monomer, a monomer containing a carboxylic acid or sulfonic acid group and diallyamine or derivative are claimed. Further, the ter-polymers may be used in personal care or personal washing compositions optionally in the presence of conditioning agents such as silicone, fatty amines, fatty amine oxides and fatty quaternaries and/or various benefit agents. The ter-polymer compositions are especially useful in the treatment of keratin-containing substrates. Keratin substrates include, but are not limited to, animal and human hair, skin and nails.
    Type: Grant
    Filed: February 24, 2010
    Date of Patent: March 4, 2014
    Assignee: BASF SE
    Inventors: Manuel Gamez-Garcia, Xian-Zhi Zhou
  • Patent number: 8663613
    Abstract: Disclosed are hair or skin conditioning compositions comprising by weight: (a) from about 0.1% to about 10% of a thickening polymer system; (b) from about 0.1% to about 8.0% of a surfactant system selected from the group consisting of cationic surfactant, nonionic surfactant, and mixtures thereof; (c) from about 0.1% to about 10% of a hydrophobically modified amido silicone copolyol; and (d) an aqueous carrier; wherein the composition has a transmittance of 25% or more and/or wherein the composition has a viscosity of from about 1,000 cps to about 50,000 cps and Shear Thinning Index of 30 or more. The compositions are especially suitable for hair care products such as hair conditioning products for rinse-off/leave-on use.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: March 4, 2014
    Assignee: The Procter & Gamble Company
    Inventors: Nobuaki Uehara, Satomi Asari, Natsumi Komure
  • Patent number: 8663614
    Abstract: The present invention relates to a method of shaving the skin, in particular the facial skin of men, using a composition comprising, in a cosmetically acceptable medium, at least one salicylic acid derivative of formula in which: R represents a linear, branched or cyclic, saturated aliphatic chain containing from 3 to 11 carbon atoms; an unsaturated aliphatic chain containing from 3 to 17 carbon atoms bearing one or more conjugated or nonconjugated double bonds; an aromatic nucleus linked to the carbonyl radical directly or by means of saturated or unsaturated aliphatic chains containing from 2 to 7 carbon atoms; it being possible for said R groups to be substituted with one or more substituents, which may be identical or different, chosen from halogen atoms, a trifluoromethyl group, a hydroxyl group in free form or in a form esterified with an acid containing from 1 to 6 carbon atoms or else with a carboxyl function, which is free or esterified with a C1-C6 alcohol; R? represents a hydroxyl group or an
    Type: Grant
    Filed: October 7, 2009
    Date of Patent: March 4, 2014
    Assignee: L'Oreal
    Inventor: Lionel Aubert
  • Patent number: 8663615
    Abstract: The present invention comprises a bio-polymer based solid for the sustained release of an active agent into the air consisting of: a) a primary starched—based polymer; b) a secondary polyether block amide polymer, and: c) a filler component. d) one or more active oils The active oils can be one or more fragrances so as to provide an air freshening composition, a flavor to create a certain aromatic environment or a repellant such as insect repellants for the elimination of mosquitoes and the like. Animal repellants may be incorporated to ward off unwanted pets and wildlife outside the home and attractants may also be utilized in the production of fishing lures and the like.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: March 4, 2014
    Inventors: Paul Joseph Albee, Jr., Eric Matthew Albee, Sandra Albee Keeley
  • Patent number: 8663616
    Abstract: Disclosed herein are compositions and methods to treat an oral cavity surface with a peracid-based benefit agent. The peracid benefit agent can be use for oral surface bleaching, whitening, disinfecting, destaining, deodorizing, decreasing or removing biofilm, and combinations thereof. The peracid is enzymatically generated from a carboxylic acid ester substrate using a CE-7 carbohydrate esterase having perhydrolytic activity (perhydrolase) in the presence of a source of peroxygen. A fusion protein comprising the perhydrolase coupled to a peptidic component having affinity for an oral cavity surface, either directly or through an optional linker, may be used to target the perhydrolytic activity to the oral cavity surface.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: March 4, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: Lisa A. Butterick, Scott D. Cunningham, Robert DiCosimo, Kari A. Fosser, Tanja Maria Gruber, Sharon L. Haynie, Mark S. Payne, Pierre E. Rouviere, Hong Wang
  • Patent number: 8663617
    Abstract: The current invention relates to methods and compositions for the treatment of wounds in a mammalian subject. Particularly, the invention relates to novel polypeptides and encoding nucleic acids that stimulate keratinocyte and endothelial cell motility and/or proliferation.
    Type: Grant
    Filed: October 16, 2012
    Date of Patent: March 4, 2014
    Assignee: Tufts University
    Inventor: Ira M Herman
  • Patent number: 8663618
    Abstract: A process for surface modification of polymer that enhances cell growth as well as inhibits growth of microorganisms is disclosed.
    Type: Grant
    Filed: March 9, 2011
    Date of Patent: March 4, 2014
    Assignee: Council of Scientific & Industrial Research
    Inventors: Prasad L. V. Bhagavatula, Virginia D. Britto
  • Patent number: 8663619
    Abstract: Provided herein are uses of murgantiol for attracting stink bugs in indoor settings. Stink bug traps comprising murgantiol and methods of using murgantiol in traps indoors are provided. Compositions comprising murgantiol are also described.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: March 4, 2014
    Assignee: Sterling International Inc.
    Inventors: Qing-He Zhang, Rodney G. Schneidmiller, Guiji Zhou, Doreen R. Hoover
  • Patent number: 8663620
    Abstract: Provided herein are uses of the Harlequin bug pheromone, murgantiol, alone or in a synergistic combination with at least one other stink bug attractant, such as methyl (2E,4E,6Z)-decatrienoate or methyl (2E,4Z)-decadienoate, or both, for attracting stink bugs such as the brown marmorated stink bug in outdoor settings. Stink bug traps comprising murgantiol, or synergistic compositions comprising murgantiol with at least one other stink bug attractant, and methods of using these compositions in traps outdoors are provided. Compositions comprising murgantiol are also described as synergistic combinations of murgantiol with at least one other stink bug attractant.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: March 4, 2014
    Assignee: Sterling International Inc.
    Inventors: Qing-He Zhang, Rodney G. Schneidmiller, Guiji Zhou, Doreen R. Hoover
  • Patent number: 8663621
    Abstract: An unsaturated hydroxyl-ester pheromone for the neotropical root weevil Diaprepes abbreviatus has been isolated, identified and synthesized. It is useful for trapping the weevil to reduce or prevent damage to plants.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: March 4, 2014
    Assignee: The United States of America, as represented by The Secretary of Agriculture
    Inventors: Stephen L Lapointe, Ashot Khrimian, Joseph C Dickens, Peter Edmund Alan Teal, Fatma Kaplan
  • Patent number: 8663622
    Abstract: The invention is directed to compositions capable of augmenting the immunogenicity of a vaccine. The composition, or adjuvant, is administered to a mammal in need thereof in sequential or concurrent combination with a vaccine antigen. In one preferred aspect, the adjuvant is provided in the form of a recombinant poxvirus vector, such as a vaccinia virus vector, which comprises a nucleic acid sequence encoding IL-15.
    Type: Grant
    Filed: December 15, 2003
    Date of Patent: March 4, 2014
    Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
    Inventors: Liyanage P. Perera, Thomas A. Waldmann, Sang-Kon Oh, Jay A. Berzofsky
  • Patent number: 8663623
    Abstract: The present invention relates to multi purpose herbal cattle feed supplement compositions for enhancing the productivity and quality of milk by improved bioavailability/bioenhancing of nutrients. The herbal composition comprises an effective amount of an extract and/or at least one bioactive fraction or powder from herbs such as Asparagus, Withania, Lepidium, Bacopa, Nardostachys, Vetiveria, Pueraria, Emblica, Tinospora etc.; one or more additive selected from Probiotics, decorticated cotton seed extract (DCC), chelated mineral mixture, mineral nutrients, dicalcium phosphate (DCP), dolomite, calcite, vitamins and amino acids to obtain the herbal feed supplement compositions.
    Type: Grant
    Filed: October 12, 2009
    Date of Patent: March 4, 2014
    Inventor: Prashant Neminath Patil
  • Patent number: 8663624
    Abstract: The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
    Type: Grant
    Filed: October 5, 2011
    Date of Patent: March 4, 2014
    Assignee: The Regents of the University of California
    Inventors: David V. Schaffer, Ryan R. Klimczak, James T. Koerber, John G. Flannery
  • Patent number: 8663625
    Abstract: The present invention relates to a monolithic biomaterial. The monolithic biomaterial has a primary network of convective flow, microfluidic channels that are embedded in a substrate, where the substrate is diffusively permeable to aqueous solutes. The present invention also relates to a method of making the monolithic biomaterial, as well as methods of using the monolithic biomaterial to facilitate healing of a cutaneous wound of a mammalian subject and of regulating cells.
    Type: Grant
    Filed: October 17, 2005
    Date of Patent: March 4, 2014
    Assignee: Cornell Research Foundation
    Inventors: Abraham D. Stroock, Mario Cabodi, Lawrence Bonassar
  • Patent number: 8663626
    Abstract: An isolated composition of matter is provided comprising a heterogeneous population of cells seeded on a surface of a scaffold, wherein the heterogeneous population of cells comprises at least one pancreatic islet, endothelial cells and fibroblast cells. Methods of generating same and uses thereof are also provided.
    Type: Grant
    Filed: March 12, 2008
    Date of Patent: March 4, 2014
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Shulamit Levenberg, Keren Francis
  • Patent number: 8663627
    Abstract: Methods, compositions, and kits for repairing damaged myocardium and/or myocardial cells including the administration cytokines are disclosed and claimed. Methods and compositions for the development of large arteries and vessels are also disclosed and claimed. The present application also discloses and claims methods and media for the growth, expansion, and activation of human cardiac stem cells.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: March 4, 2014
    Assignee: New York Medical College
    Inventor: Piero Anversa
  • Patent number: 8663628
    Abstract: An enzymatic solid phase reaction for preparing a solid having greater than 40% monoglyceride from a reaction mixture; wherein the reaction mixture comprises: (i) lipase; (ii) at least 14 weight % glycerol; and (iii) glyceride; and optionally (iv) lecithin; such that if (iv) is not present then the glyceride (iii) has an iodine value of between about 5 and about 35, and a solid fat content of more than about 75% at 20° C. The present invention further relates to a process of preparing an enzymatic solid phase reaction mixture for preparing a solid having greater than 40% monoglyceride.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: March 4, 2014
    Assignee: Dupont Nutrition Biosciences APS
    Inventor: Jorn B. Soe
  • Patent number: 8663629
    Abstract: This invention provides: novel protein homologous of a Kunitz domain, which are capable of binding kallikrein; polynucleotides that encode such novel proteins; and vectors and transformed host cells containing these polynucleotides.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: March 4, 2014
    Assignee: Dyax Corp.
    Inventors: William Markland, Robert C. Ladner
  • Patent number: 8663630
    Abstract: The molecular mechanisms of peroxisome biogenesis have begun to emerge; in contrast, relatively little is known about how the organelle functions as cells age. The present inventors characterized age-related changes in peroxisomes of human cells and showed that aging compromises peroxisomal targeting signal 1 (PTS1) protein import, with the critical antioxidant enzyme, catalase, especially affected. The number and appearance of peroxisomes are altered in these cells, and the organelles accumulate the PTS1-import receptor, Pex5p, on their membranes. Concomitantly, cells produce increasing amounts of the toxic metabolite, H2O2, and this increased load of reactive oxygen species (ROS) may further reduce peroxisomal protein import and exacerbate the effects of aging.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: March 4, 2014
    Assignee: Wayne State University
    Inventors: Stanley R. Terlecky, Paul A. Walton
  • Patent number: 8663631
    Abstract: The present invention provides methods of treating LAL deficiency comprising administering to a mammal a therapeutically effective amount of lysosomal acid lipase with an effective dosage frequency. Methods of improving growth and liver function, increasing LAL tissue concentration, and increasing LAL activity in a human patient suffering from LAL deficiency are also provided.
    Type: Grant
    Filed: September 9, 2011
    Date of Patent: March 4, 2014
    Assignee: Synageva Biopharma Corporation
    Inventor: Anthony Quinn
  • Patent number: 8663632
    Abstract: Compositions and methods of treating cancer using a thiaminase compound are described. The presently-disclosed subject matter includes a method of treating cancer by administering a thiaminase compound and a thiamine-dependent enzyme inhibitor.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: March 4, 2014
    Assignee: University of Kentucky Research Foundation
    Inventors: Jeffrey Moscow, Shuqian Liu, Younsoo Bae
  • Patent number: 8663633
    Abstract: Methods for identifying modified proteases with modified substrate specificity or other properties are provided. The methods screen candidate and modified proteases by contacting them with a substrate, such as a serpin, an alpha macroglobulins or a p35 family protein or modified serpins and modified p35 family members or modified alpha macroglobulins, that, upon cleavage of the substrate, traps the protease by forming a stable complex. Also provided are modified proteases.
    Type: Grant
    Filed: July 2, 2012
    Date of Patent: March 4, 2014
    Assignees: Torrey Pines Institute for Molecular Studies, Catalyst Biosciences, Inc.
    Inventor: Edwin L. Madison
  • Patent number: 8663634
    Abstract: The present invention provides methods of treating, preventing or ameliorating the symptoms of T cell-mediated immunological diseases, particularly autoimmune diseases, through the use of anti-CD3 antibodies. In particular, the methods of the invention provide for administration of antibodies that specifically bind the epsilon subunit within the human CD3 complex. Such antibodies modulate the T cell receptor/alloantigen interaction and, thus, regulate the T cell mediated cytotoxicity associated with autoimmune disorders. Additionally, the invention provides for modification of the anti-CD3 antibodies such that they exhibit reduced or eliminated effector function and T cell activation as compared to non-modified anti-CD3 antibodies.
    Type: Grant
    Filed: July 11, 2006
    Date of Patent: March 4, 2014
    Assignee: MacroGenics, Inc.
    Inventors: Scott Koenig, Ronald Wilder, Ezio Bonvini, Leslie S. Johnson
  • Patent number: 8663635
    Abstract: The present invention provides methods of diagnosis, providing a prognosis and a therapeutic target for the treatment of cancers that express N-cadherin, including prostrate and bladder cancers.
    Type: Grant
    Filed: November 10, 2008
    Date of Patent: March 4, 2014
    Assignee: The Regents of the University of California
    Inventor: Robert E. Reiter
  • Patent number: 8663636
    Abstract: The invention relates to targeted binding agents against DLL4 and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to DLL4. The described targeted binding agents are useful in the treatment of diseases associated with the activity and/or overproduction of DLL4 and as diagnostics.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: March 4, 2014
    Assignee: MedImmune, LLC
    Inventors: Ian Foltz, David Jenkins, Vahe Bedian
  • Patent number: 8663637
    Abstract: The present invention relates to antibodies against specific domains of Olfml3 and the use of such in angiogenesis. In particular aspects, angiogenesis-related conditions, such as cancer, can be treated by the composition comprising the Olfml3 antagonists.
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: March 4, 2014
    Assignee: Research Development Foundation
    Inventors: Beat A. Imhof, Marijana Miljkovic-Licina, Philippe Hammel
  • Patent number: 8663638
    Abstract: The invention describes the use of trifunctional bispecific and trispecific antibodies for destroying tumor cells which e.g. are disseminated intraperitoneally due to a surgical intervention, wherein the antibody is administered intraoperatively, preferably directly locally into the abdominal cavity.
    Type: Grant
    Filed: September 4, 2008
    Date of Patent: March 4, 2014
    Assignee: Trion Pharma GmbH
    Inventors: Horst Lindhofer, Markus M. Heiss