Patents Issued in March 4, 2014
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Patent number: 8664141Abstract: Provided is a silver-supported alumina catalyst for reducing nitrogen oxides using ethanol, which has the drawbacks of the conventional silver-supported alumina catalysts improved, has high performance, is not likely to deteriorate over time, and has excellent initial performance and durability. A catalyst for purifying nitrogen oxides, which purifies nitrogen oxides in exhaust gas using an alcohol as a reducing agent, and contains alumina, aluminum sulfate and silver as main components.Type: GrantFiled: July 29, 2009Date of Patent: March 4, 2014Assignee: Babcock-Hitachi Kabushiki KaishaInventors: Masatoshi Fujisawa, Yasuyoshi Kato
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Patent number: 8664142Abstract: Disclosed is a method for preparing a solid catalyst for propylene polymerization, specifically to a method for preparing a solid catalyst for propylene polymerization which can produce a polypropylene having high melt flow rate, a wide molecular distribution and excellent stereoregularity with a high production yield.Type: GrantFiled: October 1, 2010Date of Patent: March 4, 2014Assignee: Samsung Total Petrochemicals Co., Ltd.Inventors: Sang Yull Kim, Joon Ryeo Park, Eun Il Kim, Jin Woo Lee
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Patent number: 8664143Abstract: A metal oxide-carbon composite includes a carbon aerogel with an oxide overcoat. The metal oxide-carbon composite is made by providing a carbon aerogel, immersing the carbon aerogel in a metal oxide sol under a vacuum, raising the carbon aerogel with the metal oxide sol to atmospheric pressure, curing the carbon aerogel with the metal oxide sol at room temperature, and drying the carbon aerogel with the metal oxide sol to produce the metal oxide-carbon composite. The step of providing a carbon aerogel can provide an activated carbon aerogel or provide a carbon aerogel with carbon nanotubes that make the carbon aerogel mechanically robust.Type: GrantFiled: October 25, 2011Date of Patent: March 4, 2014Assignee: Lawrence Livermore National Security, LLC.Inventors: Marcus A. Worsley, Thomas Yong-Jin Han, Joshua D. Kuntz, Octavio Cervantes, Alexander E. Gash, Theodore F. Baumann, Joe H. Satcher, Jr.
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Patent number: 8664144Abstract: A method of reactivating a spent catalyst comprising a metal and a catalyst support, the method comprising redispersing the metal in the spent catalyst to produce a redispersed spent catalyst, contacting the redispersed spent catalyst with a reactivating composition to produce a redispersed, reactivated spent catalyst, and thermally treating the redispersed, reactivated spent catalyst to produce a reactivated catalyst.Type: GrantFiled: November 12, 2009Date of Patent: March 4, 2014Assignee: Chevron Phillips Chemical Company LPInventor: An-Hsiang Wu
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Patent number: 8664145Abstract: A method of preparing a fresh catalyst comprising impregnating a metal into a catalyst support to produce an impregnated catalyst, dispersing the metal in the impregnated catalyst to produce an impregnated, dispersed catalyst, contacting the impregnated, dispersed catalyst with an activating composition to produce an impregnated, dispersed, activated catalyst, and thermally treating the impregnated, dispersed, activated catalyst to produce a fresh catalyst wherein the activating composition is in the liquid phase.Type: GrantFiled: November 12, 2009Date of Patent: March 4, 2014Assignee: Chevron Phillips Chemical Company LPInventor: An-Hsiang Wu
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Patent number: 8664146Abstract: A bulk metal oxide catalyst composition of the general formula (X)b(M)c(Z)d(O)e??(I) wherein X represents at least one non-noble Group VIII metal; M represents at least one non-noble Group VIb metal; Z represents one or more elements selected from aluminum, silicon, magnesium, titanium, zirconium, boron, and zinc; one of b and c is the integer 1; and d and e and the other of b and c each are a number greater than 0 such that the molar ratio of b:c is in the range of from 0.5:1 to 5:1, the molar ratio of d:c is in the range of from 0.2:1 to 50:1, and the molar ratio of e:c is in the range of from 3.7:1 to 108:1; is prepared by controlled (co)precipitation of component metal compounds, refractory oxide material, and alkali compound in protic liquid. Resulting compositions find use in hydrotreatment processes involving particularly hydrodesulphurization and hydrodenitrification.Type: GrantFiled: November 17, 2011Date of Patent: March 4, 2014Assignee: Shell Oil CompanyInventors: Laszlo Domokos, Hermanus Jongkind, Johannes Anthonius Robert Van Veen
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Patent number: 8664147Abstract: This invention concerns a procedure for the formation of a bimetallic composition by means of the subsequent depositing of Co(0) and Pd(0) on an inert support, a composition obtained by means of said procedure and the use of said bimetallic composition as a catalyst. Another aspect of this invention is a catalytic device that includes said bimetallic composition.Type: GrantFiled: December 28, 2010Date of Patent: March 4, 2014Assignee: QID S.R.L.Inventors: Valentina Bello, Helmut Boen-Nemann, Paolo Canu, Massimo Centazzo, Luca Conte, Daniela Dalle Nogare, Giovanni Mattei, Renzo Rosei
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Patent number: 8664148Abstract: Use of physical vapor deposition methodologies to deposit nanoscale gold on activating support media makes the use of catalytically active gold dramatically easier and opens the door to significant improvements associated with developing, making, and using gold-based, catalytic systems. The present invention, therefore, relates to novel features, ingredients, and formulations of gold-based, heterogeneous catalyst systems generally comprising nanoscale gold deposited onto a nanoporous support.Type: GrantFiled: July 24, 2013Date of Patent: March 4, 2014Assignee: 3M Innovative Properties CompanyInventors: Larry A. Brey, Thomas E. Wood, Gina M. Buccellato, Marvin E. Jones, Craig S. Chamberlain, Allen R. Siedle
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Patent number: 8664149Abstract: Heterogeneous catalyst systems, methods of making these systems, and methods of using these systems, wherein catalytically active gold is deposited onto composite support media. The composite support media is formed by providing nanoporous material on at least a portion of the surfaces of carbonaceous host material. In representative embodiments, relatively fine, nanoporous guest particles are coated or otherwise provided on surfaces of relatively coarser activated carbon particles. Catalytically active gold may be deposited onto one or both of the guest or host materials either before or after the guest and host materials are combined to from the composite host material. PVD is the preferred catalyst system of depositing gold.Type: GrantFiled: July 24, 2013Date of Patent: March 4, 2014Assignee: 3M Innovative Properties CompanyInventors: John T. Brady, Marvin E. Jones, Larry A. Brey, Gina M. Buccellato, Craig S. Chamberlain, John S. Huberty, Allen R. Siedle, Thomas E. Wood, Badri Veeraraghavan, Duane D. Fansler
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Patent number: 8664150Abstract: Methods of producing a metal oxide are disclosed. The method comprises dissolving a metal salt in a reaction solvent to form a metal salt/reaction solvent solution. The metal salt is converted to a metal oxide and a caustic solution is added to the metal oxide/reaction solvent solution to adjust the pH of the metal oxide/reaction solvent solution to less than approximately 7.0. The metal oxide is precipitated and recovered. A method of producing adsorption media including the metal oxide is also disclosed, as is a precursor of an active component including particles of a metal oxide.Type: GrantFiled: March 16, 2010Date of Patent: March 4, 2014Assignee: Battelle Energy Alliance, LLCInventors: Nicholas R. Mann, Troy J. Tranter
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Patent number: 8664151Abstract: Articles, such as absorbent articles, are described, comprising a coating or film, for example applied to superabsorbent polymer particles, the coating or film containing a polyurethane polymer material, containing polyurethane polymers with covalently bonded modified silica-containing material.Type: GrantFiled: May 1, 2012Date of Patent: March 4, 2014Assignee: The Procter & Gamble CompanyInventors: Karl Haeberle, Klaus Dieter Hoerner, Jensen Kiziri Buhiru, Axel Meyer, Michaela Monika Czupik, Robin Lynn McKiernan
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Patent number: 8664152Abstract: The present invention provides a porous cellulose gel having a high mechanical strength capable of being operated at a higher flow rate, and a method for producing the same. To a suspension liquid of cellulose particles, a crosslinking agent in an amount of from 4 to 12 times the amount of the cellulose monomer in terms of moles and an alkali in an amount of from 0.1 to 1.5 times the amount of the crosslinking agent in terms of moles are added continuously dropwise or added dividedly over a prescribed period of time, whereby flow rate characteristics of a resulting porous cellulose gel can be enhanced. According to the invention, the production efficiency of a polymer substance, such as a nucleic acid and a protein can be enhanced.Type: GrantFiled: August 27, 2008Date of Patent: March 4, 2014Assignee: JNC CorporationInventors: Yasuto Umeda, Yasuo Matsumoto, Masami Shiina, Masami Todokoro, Yoshihiro Matsumoto
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Patent number: 8664153Abstract: The present teachings relate to processes to impregnate activated carbon derived from a vegetal source with permanganate and optionally, iron (III) oxide. The present teachings also include the adsorbent compositions resulting from such processes.Type: GrantFiled: May 23, 2013Date of Patent: March 4, 2014Assignee: Sociedad Oxidquimica LimitadaInventor: Eduardo Ahumada
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Patent number: 8664154Abstract: The present disclosure relates to methods of making and using activated carbon-containing coated substrates, and products made therefrom.Type: GrantFiled: June 20, 2013Date of Patent: March 4, 2014Assignee: Corning IncorporatedInventors: Kishor Purushottam Gadkaree, Andrew Fleitz Husted, James Robert Lim
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Patent number: 8664155Abstract: The present invention provides a process for producing an activated carbon having a small average particle diameter, a uniform particle size and a relatively large specific surface area suitable for an electric double layer capacitor electrode, in an easy and cost effective manner. The process comprises calcining an easily graphitizable carbon material such as petroleum coke or coal coke, used as the raw material under an oxidizing gas atmosphere, adjusting the particle size of the carbon material, and then activating the carbon material. The use of the activated carbon produced by the process of the present invention in an electrode can provide an electric double layer capacitor having a large capacitance per unit volume.Type: GrantFiled: September 11, 2009Date of Patent: March 4, 2014Assignee: JX Nippon Oil & Energy CorporationInventors: Masaki Fujii, Shinya Taguchi, Yutaka Sanokawa, Keizo Ikai
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Patent number: 8664156Abstract: An irreversible thermochromic ink composition can include thermochromic pigment capsules dispersed in a carrier. The irreversible thermochromic pigment capsules can include an inner core having a color changing dye, a color activator for activating the color changing dye, and a wax, an outer core surrounding the inner core and comprising a color destroying agent, and a shell surrounding the outer core. Alternatively, the irreversible thermochromic pigment capsules can include an inner core having a color destroying agent and a wax, an outer core surrounding the inner core and comprising a color changing dye and a color activator for activating the color changing dye, and a shell surrounding the outer core. Written marks made with the irreversible thermochromic inks can be rendered a different color or substantially colorless by application of a sufficient amount of heat to melt or substantially liquefy the wax in the irreversible thermochromic pigment capsules.Type: GrantFiled: December 31, 2011Date of Patent: March 4, 2014Assignee: Sanford, L.P.Inventor: Wing Sum V. Kwan
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Patent number: 8664157Abstract: An object of the present invention is to provide a recording material or a recording sheet that is excellent not only in whiteness of a background but also in storage property for a background and an image, and further has excellent dynamic sensitivity. In order to achieve the object, a phenol compound represented by Formula (I) [wherein R1 represents a hydroxyl group or a halogen atom, p represents 0 or an integer of 1 to 5, R2 and R3 each independently represent a hydrogen atom or a C1-C6 alkyl group, R4 represents a hydrogen atom, a C1-C6 alkyl group, an optionally substituted phenyl group or an optionally substituted benzyl group; and a bond shown with a wavy line represents E- or Z-form, or a mixture thereof] and having a color space b* of 10 or less, and preferably having brightness by Hunter of 75 or more, is used as a recording material.Type: GrantFiled: August 29, 2011Date of Patent: March 4, 2014Assignee: Nippon Soda Co., Ltd.Inventors: Hiroshi Sakai, Shuntaro Kinoshita, Tadahiro Kondo, Kazumi Jyujyo
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Patent number: 8664158Abstract: An Ink transfer medium configured to receive and transfer an image on a bi-dimensional or tri-dimensional article by way of thermal transfer. The ink transfer medium includes a sub-layer made of amorphous polyethylene terephthalate (APET), an image receiving coating, a barrier coating, a binding system, and an ink transfer coating which includes a layer having a combination of pigment systems formed by cellulose fibers, microspheres and silica. The barrier coating includes resins and mineral elements supporting the ink transfer coating applied on the APET film.Type: GrantFiled: February 18, 2010Date of Patent: March 4, 2014Assignee: Policrom Screens S.p.A.Inventor: Giorgio Vavassori Bisutti
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Patent number: 8664159Abstract: The present invention relates to a thermal transfer image-receiving sheet including a dye receiving layer formed of a resin composition for thermal transfer image-receiving sheets, wherein said resin composition includes a resin composition (A) containing a graft polymer (A0) which contains a main chain segment (A1) formed of a polyester resin obtained by polycondensing an alcohol component containing an alkyleneoxide adduct of 2,2-bis(4-hydroxyphenyl)propane in an amount of 50 mol % or more with a carboxylic acid component, and a side chain segment (A2) formed of an addition polymer-based resin, and has a glass transition temperature of 50° C. or higher; and a resin composition (B) containing a resin (B0) and having a glass transition temperature lower by from 10 to 80° C. than the glass transition temperature of the resin composition (A), and to a process for producing the thermal transfer image-receiving sheet.Type: GrantFiled: December 22, 2010Date of Patent: March 4, 2014Assignee: Kao CorporationInventors: Yuuta Matsumoto, Nobumichi Kamiyoshi, Yoshiaki Ban, Takashi Mukai
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Patent number: 8664160Abstract: Fungicidal mixtures, comprising (1) triticonazole of the formula I or salts or adducts thereof and (2) pyraclostrobin of the formula II and (3) at least one acylalanine selected from the group consisting of metalaxyl-M of the formula III and (4) kiralaxyl of the formula IV in a synergistically effective amount, methods for controlling harmful fungi using mixtures of the compounds I to III or I, II and IV and the use of the compounds I to III or I, II and IV for preparing such mixtures, and also compositions comprising such mixtures.Type: GrantFiled: November 6, 2006Date of Patent: March 4, 2014Assignee: BASF SEInventors: Hendrik Ypema, Andreas Hopf, Nathan Froese, Reinhard Stierl
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Patent number: 8664161Abstract: A composition and method increases storage stability of cut flowers, particularly roses. A liquid composition is applied onto the cut flowers, and then it is converted to a protective polymeric film of a thickness of from about 0.001 to about 0.5 mm.Type: GrantFiled: October 31, 2008Date of Patent: March 4, 2014Assignee: Greenoy Ltd.Inventor: Jaron Tandler
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Patent number: 8664162Abstract: The present invention provides methods for applying active ingredients including pesticides, plant growth regulators and plant nutrients to plants by applying formulations comprising the active ingredients and a solvent to the soil around a plant.Type: GrantFiled: July 24, 2009Date of Patent: March 4, 2014Assignee: ArborSystemsInventor: Glayne D. Doolittle, Jr.
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Patent number: 8664163Abstract: Described is an article including a sapphire substrate carrying a superconductive layer of a compound of the formula YBa2Cu3O7-x (YBCO), the layer having surface area of at least 10 cm2, and critical current of at least 100 A/cm width at a temperature of 77K or higher. In one exemplary embodiment, the thickness of the superconductive layer is between 10 nm and 50 nm. In another exemplary embodiment, the thickness of the superconductive layer is more than 600 nm. In preferred embodiment, an YSZ layer and a non-superconductive YBCO layer separate between the superconductive layer and the substrate.Type: GrantFiled: January 14, 2010Date of Patent: March 4, 2014Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Guy Deutscher, Mishael Azoulay, Boaz Almog
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Patent number: 8664164Abstract: The present invention provides a method for detecting or enriching for a target deoxyribonucleic acid (DNA) present in a nucleic acid sample, said method comprising: (a) fragmenting a nucleic acid sample to generate nucleic acid fragments including a target fragment containing said target DNA and non-specifically ligating an adaptor sequence to an end of said fragments; (b) rendering said fragments at least partially single-stranded; (c) contacting the at least partially single-stranded fragments of step (b) with oligonucleotides A and B of a single target-specific nucleic acid probe; (d) ligating oligonucleotide B of said probe to the part of the single-stranded portion of said target fragment which is hybridised to oligonucleotide A of said probe to produce a probe-target fragment hybrid; and (e) detecting or enriching for said probe-target fragment hybrid.Type: GrantFiled: July 23, 2010Date of Patent: March 4, 2014Assignee: Agilent Technologies, Inc.Inventors: Olof Ericsson, Magnus Isaksson, Henrik Johansson, Ulf Landegren
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Patent number: 8664165Abstract: A fluid loss pill that includes a crosslinked polymer gel, a brine, and solid salt particles disposed in said gel is described. Further, a method for reducing fluid loss that includes pumping a selected amount of a fluid loss pill into a wellbore leading to an oil-, condensate-, or gas-producing formation, the fluid loss pill including a crosslinked polymer gel, a brine, and solid salt particles disposed in said gel is described.Type: GrantFiled: June 29, 2006Date of Patent: March 4, 2014Assignee: M-I L.L.C.Inventors: Robert L. Horton, Bethicia B. Prasek
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Patent number: 8664166Abstract: A method of treating a hydrocarbon containing formation, comprising (a) providing a composition to at least a portion of the hydrocarbon containing formation, wherein the composition comprises a derivative selected from the group consisting of a carboxylate or a sulfate or glycerol sulfonate of an ethoxylated/propoxylated primary alcohol having a branched aliphatic group with an average carbon number from 10 to 24 and having an average number of branches per aliphatic group of from 0.7 to 2.5 and having at least 0.5 moles of propylene oxide per mole of primary alcohol and having at least 0.5 moles of ethylene oxide per mole of primary alcohol; and (b) allowing the composition to interact with hydrocarbons in the hydrocarbon containing formation.Type: GrantFiled: February 6, 2009Date of Patent: March 4, 2014Assignee: Shell Oil CompanyInventors: Kirk Herbert Raney, Thomas Carl Semple
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Patent number: 8664167Abstract: A method of treating a hydrocarbon containing formation, comprising (a) providing a hydrocarbon recovery composition to at least a portion of the hydrocarbon containing formation, wherein the hydrocarbon recovery composition comprises a propoxylated composition which comprises (1) a glycerol sulfonate of a propoxylated primary alcohol having a branched aliphatic group with an average carbon number from 10 to 24 and having an average number of branches per aliphatic group of from 0.7 to 2.5 and having at least 0.Type: GrantFiled: February 6, 2009Date of Patent: March 4, 2014Assignee: Shell Oil CompanyInventors: Kirk Herbert Raney, Thomas Carl Semple
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Patent number: 8664168Abstract: A well treatment composite comprising a well treatment agent adsorbed onto a water-insoluble adsorbent may be prepared by precipitating the well treatment agent, in the presence of a metal salt, from a liquid while the well treatment agent is being adsorbed onto the water-insoluble adsorbent. After a treatment fluid containing the composite is introduced into a well or a subterranean formation, the well treatment agent is slowly released from the composite. The composite permits a continuous supply of the well treatment agent into a targeted area and is particularly effective in high pH treatment fluids.Type: GrantFiled: March 30, 2011Date of Patent: March 4, 2014Assignee: Baker Hughes IncorporatedInventor: William H. Steiner
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Patent number: 8664169Abstract: The present disclosure relates to lubricating compositions for transmissions, in particular for gear boxes, and to the use thereof for limiting the fuel consumption of motor vehicles. The compositions according to the disclosure are suitable for all types of vehicles, especially light vehicles, and are particularly suitable for hybrid engine vehicles.Type: GrantFiled: October 2, 2009Date of Patent: March 4, 2014Assignee: Total Marketing ServicesInventor: Alain Bouffet
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Patent number: 8664170Abstract: The present invention is directed to a method for preparing an unsulfurized, carboxylate-containing additive for lubricating oils and the product produced by said method, wherein said method comprises a) neutralization of a mixture of at least two alkyl phenols using an alkaline earth base in the presence of a promoter, to produce a mixture of alkyl phenates, wherein the mixture of at least two alkyl phenols comprises at least a first alkyl phenol wherein the alkyl group is derived from an isomerized alpha olefin and a second alkyl phenol wherein the alkyl group is derived from a branched chain olefin; (b) carboxylation of the mixture of alkyl phenates obtained in step (a) using carbon dioxide under carboxylation conditions sufficient to convert at least 20 mole % of the starting alkyl phenols to alkyl salicylate; and (c) removal of at least about 10% of the starting mixture of at least two alkyl phenols from the product produced in step (b) to produce said additive.Type: GrantFiled: February 15, 2013Date of Patent: March 4, 2014Assignee: Chevron Oronite Company LLCInventors: Curtis Bay Campbell, Eugene Edward Spala, Willie Horn, Jr.
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Patent number: 8664171Abstract: This invention relates to products useful in friction-reducing extreme-pressure lubricating applications such as internal combustion engines, gear oils and applications which involve rubbing metallic moving parts. The invention includes additive blends and a process of using synergistic combinations of nitro compounds with non-chlorine containing additives such as sulfur-containing moieties and phosphorus-containing moieties.Type: GrantFiled: August 8, 2008Date of Patent: March 4, 2014Assignee: Dover Chemical CorporationInventors: Donald Stevenson, Duong N. Nguyen
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Patent number: 8664172Abstract: A self-sticking disintegrating cleansing block to be attached directly to a wall of a toilet bowl or urinal, above the water-line and in the stream of flush water, by pressing the cleansing block to the wall. The cleaning block includes 25% to 99% of a solid surfactant, and 1% to 25% of a liquid component. The cleansing block may include a substrate removably attached to a surface of the cleansing block. In use, the substrate is removed from the cleansing block and the exposed surface of the cleansing block is pressed to a surface in a position above any waterline that is contacted by a rinse liquid that disintegrates the cleansing block. Rinse liquid is then allowed to contact the cleansing block such that an amount of the cleansing block is mixed with rinse fluid to clean the surface or a liquid reservoir adjacent the surface.Type: GrantFiled: January 22, 2010Date of Patent: March 4, 2014Assignee: S.C. Johnson & Son, Inc.Inventors: Jerome J. Veltman, Michael E. Klinkhammer
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Patent number: 8664173Abstract: The present invention is directed to a premoistened, disposable, cleaning substrate to improve dirt pick-up and to retard redeposition of the dirt back onto the cleaned leather surface. The said substrate is incorporated therein with a cleaning composition to improve cleaning and impart protection and/or preservation of the leather surface or article. The said substrate is further incorporated therein with UV absorbers to further protect the leather surface, improve appearance and durability. The impregnated substrate can be employed to clean leather surfaces such as furniture, clothing, shoes, belts, automobile upholstery and the like. In addition, a method of preserving a leather surface or article by contacting said surface with said substrate is disclosed.Type: GrantFiled: December 3, 2007Date of Patent: March 4, 2014Assignee: BASF SEInventors: Andress K. Johnson, Stephen E. Minter
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Patent number: 8664174Abstract: A liquid composition having a microcapsule, the microcapsule having an aldehyde-containing resin, and one or more formaldehyde scavenger which reacts with formaldehyde to achieve more than about 60% reaction completeness in about 15 minutes time at pH 8 and at about 21° C. A liquid composition having a microcapsule, the microcapsule having an aldehyde-containing resin, one or more sulfur-based formaldehyde scavenger and optionally a non-sulfur-based formaldehyde scavenger.Type: GrantFiled: September 29, 2009Date of Patent: March 4, 2014Assignee: The Procter & Gamble CompanyInventors: Karl Ghislain Braeckman, Karel Jozef Maria Depoot, Tim Roger Michel Van Pachtenbeke, Johan Smets
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Patent number: 8664175Abstract: The present invention relates to polyglycerol partial esters of linear, unsubstituted carboxylic acids and bifunctional carboxylic acids with the provisos that the polyglycerol partial ester comprises an HLB-value from 2 to 10 and that the polyglycerol obtained by hydrolysis or alcoholysis of the polyglycerol partial ester comprises an average degree of polymerization of from 2 to 8 and at least 1% of the polyglycerol comprises cyclic structures. The present invention also relates to the preparation thereof and their use in fabric and textile care products.Type: GrantFiled: January 12, 2011Date of Patent: March 4, 2014Assignee: Evonik Goldschmidt GmbHInventors: Hans Henning Wenk, Peter Lersch, Ulrike Kottke
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Patent number: 8664176Abstract: A method is disclosed for treating diseases or disorders of the eye involving undesired neovascularization by administration of a complement inhibitory protein such as soluble complement receptor type I (sCR1). The present invention relates to the direct treatment of macular degeneration, particularly age-related macular degeneration (AMD), by administering a complement inhibitory protein intraocularly or systemically.Type: GrantFiled: October 19, 2007Date of Patent: March 4, 2014Assignee: Celldex Therapeutics, Inc.Inventors: Henry C. Marsh, Lawrence Thomas, Hua Gao, Xiaoxi Qiao
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Patent number: 8664177Abstract: The present invention is directed to peptide compositions and methods of using the peptide compositions to treat prediabetes, diabetes, obesity, high blood pressure and metabolic syndrome.Type: GrantFiled: February 10, 2012Date of Patent: March 4, 2014Assignee: The Regents of the University of MichiganInventors: Yuqing E. Chen, Changyong Xue, Jifeng Zhang
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Patent number: 8664178Abstract: Acid-containing oral pharmaceutical compositions are provided wherein the pharmaceutical active agents are peptide compounds (i.e., those that include a plurality of amino acids and at least one peptide bond in their molecular structures). Certain barrier layers and/or particulate coated acid are used to reduce any adverse interactions that might otherwise occur between the acid of the compositions and other components of the composition. Use of these barrier layers and/or use of particulate coated acid is believed to promote a more simultaneous release of the components of the composition than is achieved by prior art acid-protection techniques, thus enhancing, and making more consistent, the bioavailability of the active peptide compounds.Type: GrantFiled: June 4, 2012Date of Patent: March 4, 2014Assignee: Enteris BioPharma, Inc.Inventors: William Stern, Angelo P. Consalvo
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Patent number: 8664179Abstract: A peptide with the following sequence YCQKFLWTCDSERPCCEGLVCRLWCKIN (SEQ ID NO 1) or a derivative thereof, and nucleic acids coding for the peptide having the sequence (SEQ ID NO 1). Also the use of this peptide as an antagonist and/or reverse agonist of T-type calcium channels. A use of the peptide for preparing a drug, in particular an analgesic one.Type: GrantFiled: January 15, 2010Date of Patent: March 4, 2014Assignees: Centre National de la Recherche Scientifique (CNRS), Universite de Nice Sophia AntipolisInventors: Emmanuel Bourinet, Pierre Escoubas, Fabrice Marger, Joel Nargeot, Michel Lazdunski
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Patent number: 8664180Abstract: Ophthalmic composition that includes 0.05% w/v to 2% w/v diglycine or a salt thereof; 0.01 ppm to 3 ppm poly(hexamethylene biguanide); 1 ppm to 10 ppm ?-[4-tris(2-hydroxyethyl)ammonium chloride-2-butenyl]poly[1-dimethylammonium chloride-2-butenyl]-?-tris(2-hydroxyethyl)ammonium chloride; and 0.1% w/v to 2% w/v of one or more boron buffering compounds.Type: GrantFiled: February 6, 2012Date of Patent: March 4, 2014Assignee: Bausch & Lomb IncorporatedInventors: Susan E. Burke, Erning Xia, Catherine A. Scheuer, Srini Venkatesh
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Patent number: 8664181Abstract: A prodrug comprising at least two different pharmaceutically and/or diagnostically active compounds independently bound by cleavable linkers and a protein-binding moiety which is capable of binding to carrier a molecule is described.Type: GrantFiled: February 15, 2008Date of Patent: March 4, 2014Assignee: KTB Tumorforschungsgesellschaft mbHInventors: Felix Kratz, Irmgard Merfort
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Patent number: 8664182Abstract: Methods of inhibiting cancer cell growth using HDAC10 inhibitors are provided. Methods of treating cancer in a subject using HDAC10 inhibitors are also provided. In certain embodiments, at least one second inhibitor selected from an autophagy inhibitor, an AMPK inhibitor, and methyl pyruvate is also used in the methods. Dose packs comprising HDAC10 inhibitors and at least one second inhibitor are provided. Methods of identifying HDAC10 inhibitors are also provided.Type: GrantFiled: November 10, 2009Date of Patent: March 4, 2014Assignee: Duke UniversityInventors: Tso-pang Yao, Hitoshi Sasajima, Yoshiharu Kawaguchi, Kai Cui, Chun-Hsiang Lai
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Patent number: 8664183Abstract: It is disclosed herein that SPANX-B is uniquely expressed in a number of human tumors and that SPANX-B is an immunogenic antigen that is recognized by human T cells inducing helper CD4+ and cytolytic CD8+ T cell responses. Specific SPANX-B polypeptides and polynucleotides are disclosed that can be used to generate an immune response. In several embodiments, these polypeptides can be used for the treatment of a variety of cancers, including melanoma, colon carcinoma, ovarian cancer, breast cancer, myeloma, lung carcinoma and renal cancer.Type: GrantFiled: February 26, 2010Date of Patent: March 4, 2014Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Bira Arya, Vladimir L. Larionov
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Patent number: 8664184Abstract: The invention discloses high levels of receptors for Clostridium perfringens enterotoxin (CPE) have been found in ovarian cancer and uterine cancer tissue samples. In addition, successful in vivo treatment of a mouse model of ovarian cancer with intraperitoneal injection of CPE is disclosed. High levels of Ep-CAM protein is also disclosed in ovarian cancer tissue samples. Thus, the invention provides a method of treating ovarian cancer and uterine cancer by administering CPE. The invention also provides a method of treating cancer in a mammal involving intraperitoneal administration of CPE, where at least some cancerous cells are located in or adjacent to the peritoneal cavity of the mammal. The invention also provides a method of treating ovarian cancer involving administering an anti-Ep-CAM antibody. The invention also provides a method of treating cancers expressing claudin-3 or claudin-4 by administering an antibody against claudin-3 and/or an antibody against claudin-4.Type: GrantFiled: September 30, 2011Date of Patent: March 4, 2014Assignee: Yale UniversityInventor: Alessandro D. Santin
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Patent number: 8664185Abstract: A method for preparing a concentrated spinach extract in a liquid or dry form and having a polyphenol titer greater than or equal to 50% is described. The method includes a step of purifying a raw spinach extract in a liquid form using a liquid-liquid extraction technique with a food oil.Type: GrantFiled: May 4, 2010Date of Patent: March 4, 2014Assignee: NaturexInventor: Charles Duval
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Patent number: 8664186Abstract: The present invention relates to Stambomycin compounds, their derivatives and their pharmaceutically acceptable salt thereof.Type: GrantFiled: July 23, 2010Date of Patent: March 4, 2014Assignees: Universite de Lorraine, University of Warwick, Institut National de la Recherche AgronomiqueInventors: Bertrand Aigle, Gregory Challis, Luisa Laureti, Lijiang Song, Pierre Leblond
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Patent number: 8664187Abstract: The present invention provides methods for the treatment of an endobronchial infection in a patient by administering to the endobronchial system of the patient a dry powder aerosol composition comprising from 90 to 130 mg of an aminoglycoside antibiotic one to three times a day for a first treatment period of 20 to 36 days.Type: GrantFiled: February 24, 2012Date of Patent: March 4, 2014Assignee: Novartis AGInventors: Peter Challoner, Carlos Rodriguez, Emil Samara, Thomas E Tarara, John D Lord
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Patent number: 8664188Abstract: No antiviral regimen has been consistently successful in treating H5N1 virus infection. We demonstrate that a group of highly effective siRNAs targeting different H5N1 viral genes shares a unique motif, GGAGU/ACUCC. We further demonstrate that the effectiveness of siRNAs containing this motif is not sequence specific. The results suggested that the structure of the unique motif is critical in determining the potency of siRNA-mediated protective effects against viral infection and this potent in vivo protection is associated with early productions of ?-defensin and IL-6 induced by the motif. Provided are methods and prophylactic and therapeutic agents useful against other viral infections in addition to the H5N1 influenza virus.Type: GrantFiled: December 11, 2009Date of Patent: March 4, 2014Assignee: Xiangxue Group (Hong Kong) Company LimitedInventors: Bojian Zheng, Hongyan Sui, Yongping Lin
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Patent number: 8664189Abstract: The present invention relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal applications.Type: GrantFiled: September 22, 2009Date of Patent: March 4, 2014Assignee: RXi Pharmaceuticals CorporationInventors: Anastasia Khvorova, William Salomon, Joanne Kamens, Dmitry Samarsky, Tod M. Woolf, Pamela A. Pavco, James Cardia
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Patent number: 8664190Abstract: Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating, preventing, or ameliorating hypercholesterolemia and/or atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.Type: GrantFiled: November 22, 2011Date of Patent: March 4, 2014Assignee: Isis Pharmaceuticals, Inc.Inventors: Susan M. Freier, Rosanne M. Crooke, Mark J. Graham, Kristina L. Lemonidis, Sanjay Bhanot, Diane Tribble, Andrew T. Watt