Patents Issued in March 6, 2014
  • Publication number: 20140066480
    Abstract: This document provides methods and materials related to assessing responsiveness to lenalidomide, thalidomide, and/or other IMiDs (structural and functional analogues of thalidomide that represent a promising new class of immunomodulators). For example, methods and materials for using CRBN levels to determine whether or not cancer cells (e.g., multiple myeloma cells) are susceptible to lenalidomide, thalidomide, and/or other IMiDs are provided.
    Type: Application
    Filed: March 8, 2012
    Publication date: March 6, 2014
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Alexander Keith Stewart, Peter Bergsagel, Rafael Fonseca, Esteban Braggio
  • Publication number: 20140066481
    Abstract: The present invention relates to a water-free pharmaceutical composition comprising one or more local anaesthetics in base form and which is suitable for topical administration. The composition further comprises a lipid vehicle comprising long-chain triglycerides (LCT) and at least 10% by weight of medium-chain monoglycerides (MCM) selected so the composition has an at least semi-solid appearance at the body temperature at the site of administration. The invention further relates to methods of producing and sterilizing the compositions.
    Type: Application
    Filed: March 30, 2011
    Publication date: March 6, 2014
    Applicant: PHARMANEST AB
    Inventors: Mark Sundberg, Arne Brodin, Anders Carlsson
  • Publication number: 20140066482
    Abstract: The invention is related to a pharmaceutical composition comprising repaglinide in combination with metformin or a salt thereof in unit dosage form wherein a pre-formulation of the repaglinide has a pH independent dissolution profile and a relative humidity of less than about 25% prior to mixing with the metformin or a salt thereof; and optionally one or more pharmaceutically acceptable excipients and to a method for its preparation.
    Type: Application
    Filed: November 13, 2013
    Publication date: March 6, 2014
    Applicant: Novo Nordisk A/S
    Inventors: Bent Hoejgaard, Breian Knudsen, Stella Rudkjaer Rasmussen, Lene Orup Jacobsen
  • Publication number: 20140066483
    Abstract: Disclosed herein is a method of upregulating regulatory T-cells, and treating diseases that would benefit from such upregulation, by administering an alpha 2 receptor agonist.
    Type: Application
    Filed: November 4, 2013
    Publication date: March 6, 2014
    Applicant: Allergan, Inc.
    Inventors: Daniel W. Gil, John E. Donello, Veena Viswanath, Lauren M.B. Luhrs
  • Publication number: 20140066484
    Abstract: The disclosure relates to improved methods of administering pirfenidone therapy when ciprofloxacin is administered concomitantly.
    Type: Application
    Filed: August 30, 2013
    Publication date: March 6, 2014
    Applicant: INTERMUNE, INC.
    Inventor: Williamson Z. Bradford
  • Publication number: 20140066485
    Abstract: A method for administration of ibuprofen to a subject in need of ibuprofen treatment is provided, in which an oral dosage form comprising a therapeutically effective amount of ibuprofen and a therapeutically effective amount of famotidine, in admixture, is administered three times per day.
    Type: Application
    Filed: February 15, 2013
    Publication date: March 6, 2014
    Applicant: HORIZON PHARMA USA, INC.
    Inventor: Horizon Pharma USA, Inc.
  • Publication number: 20140066486
    Abstract: This invention provides REL inhibitors which interfere with the DNA binding capacity of a REL protein. Additionally this invention provides methods of treating, abrogating, or preventing diseases which respond with a positive clinical score to a REL inhibitor. Methods of identifying REL inhibitor based on a REL protein three dimensional model are described.
    Type: Application
    Filed: August 27, 2013
    Publication date: March 6, 2014
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Youhai H. CHEN, Ramachandran MURALI, Jing SUN
  • Publication number: 20140066487
    Abstract: The present invention relates to novel compounds and compositions having antiviral activity. The invention also relates to methods for the therapeutic or prophylactic treatment of viral infections in mammals.
    Type: Application
    Filed: November 5, 2013
    Publication date: March 6, 2014
    Applicant: Biotron Limited
    Inventors: Gary Dinneen Ewart, Wayne Morris Best
  • Publication number: 20140066488
    Abstract: Proteases such as memapsin 2 are important enzymes, playing roles in a variety of diseases including Alzheimer's Disease. The inventors have developed inhibitors of memapsin 2 and methods of use therefore in the treatment of disease.
    Type: Application
    Filed: August 28, 2013
    Publication date: March 6, 2014
    Applicants: Purdue Research Foundation, Oklahoma Medical Research Foundation
    Inventors: Jordan Tang, Venkateswararao Kalapala, Arun K. Ghosh
  • Publication number: 20140066489
    Abstract: Method of exposing agricultural substrates (plant matter 10, animal matter 12) to agrochemicals (A); method of decreasing or preventing sub-surface geological matter (20, 22) contamination resulting from exposing agricultural substrates to agrochemicals; composition [(A)/(T)] 30 used therein; article-of-manufacture including the composition. Includes exposing agricultural substrates to composition including combination (mixture) of an agrochemical and at least one transforming agent capable of decreasing or eliminating concentration of the agrochemical which contacts sub-surface geological matter (at temporally varying times, and at spatially varying depths). Before entering sub-surface geological matter, transforming agent exhibits inactivity for decreasing agrochemical concentration, and inactivity for affecting or/and interfering with agrochemical functionality with respect to agricultural substrates.
    Type: Application
    Filed: November 10, 2013
    Publication date: March 6, 2014
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Brian BERKOWITZ, Ishai Dror
  • Publication number: 20140066490
    Abstract: A system and method for programming DNAzymes to be utilized as programmable drugs, which are active only in the presence of specific input combinations and/or certain conditions.
    Type: Application
    Filed: August 14, 2013
    Publication date: March 6, 2014
    Applicant: YEDA Research and Development Co. Ltd.
    Inventors: Ehud Y. SHAPIRO, Maya KANAN-HANUM, Yehonatan DOUEK, Rivka ADAR
  • Publication number: 20140066491
    Abstract: The present invention provides polynucleotides having chemistry patterns that provide for improved stability, potency, and/or toxicity relative to their use as miRNA inhibitors or miRNA mimetics. The invention further provides pharmaceutical compositions and formulations comprising the polynucleotides, and methods for treating patients having a condition associated with miRNA or mRNA expression.
    Type: Application
    Filed: August 22, 2013
    Publication date: March 6, 2014
    Applicant: MIRAGEN THERAPEUTICS
    Inventors: Christina Dalby, William S. Marshall
  • Publication number: 20140066492
    Abstract: The present invention is directed to methods and compositions capable of blocking the inhibitory effect of a newly-identified intronic inhibitory sequence element, named ISS-N1 (for “intronic splicing silencer”), located in the SMN2 gene. The compositions and methods of the instant invention include oligonucleotide reagents (e.g., oligoribonucleotides) that effectively target the SMN2 ISS-N1 site in the SMN2 pre-mRNA, thereby modulating the splicing of SMN2 pre-mRNA to include exon 7 in the processed transcript. The ISS-N1 blocking agents of the invention cause elevated expression of SMN protein, thus compensating for the loss of SMN protein expression commonly observed in subjects with spinal muscular atrophy (SMA).
    Type: Application
    Filed: October 15, 2013
    Publication date: March 6, 2014
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Ravindra N. SINGH, Natalia N. SINGH, Nirmal K. SINGH, Elliot J. ANDROPHY
  • Publication number: 20140066493
    Abstract: The present invention relates to pharmaceutical compositions useful for topical, non-invasive delivery of an oligonucleotide to the ear and to methods for the treatment of an ear disorder, including hearing loss arising from chemical-induced ototoxicity, acoustic trauma and presbycusis; and microbial infections. The method comprises topically administering to the ear of a subject in need thereof a pharmaceutical composition comprising an inhibitory oligonucleotide, a permeability enhancer and a pharmaceutically acceptable carrier, wherein the oligonucleotide reduces or inhibits expression of a gene associated with the ear disorder in the subject.
    Type: Application
    Filed: April 22, 2013
    Publication date: March 6, 2014
    Applicant: QUARK PHARMACEUTICALS, INC.
    Inventors: Evgenia Alpert, Igor Spivak, Amir Bar-Ilan
  • Publication number: 20140066494
    Abstract: The invention relates to the use of lipooxigenase inhibitors for treating acne, particularly inflammatory acne. The inventive lipooxigenase inhibitor can be used alone or in combination with other lipooxigenase inhibitors or anti-acne active agents in a pharmaceutically suitable composition, particularly through oral and/or local-topic application.
    Type: Application
    Filed: December 17, 2012
    Publication date: March 6, 2014
    Inventor: Christos C. Zouboulis
  • Publication number: 20140066495
    Abstract: The present invention provides a pharmaceutical composition for delivering an active agent taxane through transmucosal administration, more particularly through the buccal mucosa or sublingual mucosa. The present invention provides a method for treating cancer by buccal or sublingual administration of the pharmaceutical composition to a subject. The pharmaceutical composition comprises a taxane, a non-ionic surfactant, a viscosity enhancing agent, an adhesive agent, and an alcohol solvent at pH 4-6.
    Type: Application
    Filed: September 5, 2012
    Publication date: March 6, 2014
    Inventors: Ying YE, Janshon Zhu
  • Publication number: 20140066496
    Abstract: There is herein provided a composition comprising azadirachtin, preferably neem oil, and methods of use thereof for inhibiting macrofouling on a polymer in an aquatic environment.
    Type: Application
    Filed: April 11, 2012
    Publication date: March 6, 2014
    Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Nikhil A. Gunari, Mallika Das, Gilbert C. Walker
  • Publication number: 20140066497
    Abstract: This invention discloses cannabinoid derivatives and pharmaceutical uses thereof.
    Type: Application
    Filed: August 27, 2013
    Publication date: March 6, 2014
    Inventor: Craig TRAVIS
  • Publication number: 20140066498
    Abstract: The present invention relates to triterpenoid derivatives, benzenoid derivatives, and pharmaceutical compositions containing the same for treating cancers or inflammatory symptoms. According to the present invention, the triterpenoid derivatives and the benzenoid derivatives are respectively represented by the following formulas (I) and (II): wherein, R1, R2, R3, R4, R5, R6, R7, R8, , , , R1?, R2?, R3?, and R4? are defined the same as the specification.
    Type: Application
    Filed: November 8, 2013
    Publication date: March 6, 2014
    Applicant: National Cheng Kung University
    Inventor: TIAN-SHUNG WU
  • Publication number: 20140066499
    Abstract: An industrial process for production of high-purity optically active amine derivatives in high yield while inhibiting the formation of by-products, which comprises subjecting (E)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-ylidene)ethylamine to asymmetric reduction, catalytically reducing the obtained product at a reaction temperature of 40 to 100° C. and a pH of 3 to 9, subjecting the obtained (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine to propionylation, and then crystallizing the reaction mixture.
    Type: Application
    Filed: November 13, 2013
    Publication date: March 6, 2014
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Shinichi Urayama, Eigo Mutou, Atsushi Inagaki, Takashi Okada, Shigeharu Sugisaki
  • Publication number: 20140066500
    Abstract: The present invention provides novel cycloalkylmethylamine derivatives, and methods of preparing cycloalkylmethylamine derivatives. The present invention also provides methods of using cycloalkylmethylamine derivatives and compositions of cycloalkylmethylamine derivatives. The pharmaceutical compositions of the compounds of the present invention can be advantageously used for treating and/or preventing obesity and obesity related co-morbid indications and depression and depression related co-morbid indications.
    Type: Application
    Filed: November 6, 2013
    Publication date: March 6, 2014
    Applicant: Reviva Pharmaceuticals, Inc.
    Inventors: Laxminarayan BHAT, Seema BHAT
  • Publication number: 20140066501
    Abstract: Crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid anhydrate and crystalline (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl)butanoic acid hemihydrate, pharmaceutical compositions comprising such compounds, methods of making and methods of using the same are disclosed.
    Type: Application
    Filed: November 11, 2013
    Publication date: March 6, 2014
    Applicant: XenoPort, Inc.
    Inventors: Stephen P. Raillard, Suresh K. Manthati, Sudhir Joshi
  • Publication number: 20140066502
    Abstract: The present invention inter alia relates to a method of treating or preventing an arterial insufficiency, wherein an NO donor is administered in an intermitting manner to a subject in an amount effective for the induction of arteriogenesis, and wherein the NO donor is a solid pharmaceutical preparation with the active substance glyceryl trinitrate for oromucosal or oral administration characterized in that it contains between 0.05 and 2 weight % glyceryl trinitrate (GTN), at least one diluent, one carrier material, and at least one substance that reduces the volatility of GTN, whereby this substance is a non-volatile ester stabilizer whose melting point is not higher than 60° C.
    Type: Application
    Filed: May 29, 2013
    Publication date: March 6, 2014
    Inventor: Michaela Gorath
  • Publication number: 20140066503
    Abstract: A method of treating tachycardia while minimizing and/or controlling hypotension associated with such treatment includes administering a therapeutically effective amount of a pharmaceutical composition comprising the S-isomer of esmolol to a subject in need thereof.
    Type: Application
    Filed: November 8, 2013
    Publication date: March 6, 2014
    Applicants: BAXTER INTERNATIONAL INC.
    Inventors: Barrett Rabinow, Jeff McKee
  • Publication number: 20140066504
    Abstract: Novel analogs and prodrugs of the loop diuretic bumetanide are described. Pharmaceutical compositions containing bumetanide analogs and prodrugs are also described. These analogs and prodrugs are particularly useful for the treatment and/or prophylaxis of conditions that involve the NKCC cotransporter family (NKCC1 and NKCC2), or the KCC cotransporter family (KCC1, KCC2, KCC3, KCC4), or GABAa receptors. Such conditions include, but are not limited to anxiety disorders, epilepsy, migraine, non-epileptic seizures, sleep disorders, obesity, eating disorders, autism, depression, edema, glaucoma, stroke, ischemia, neuropathic pain, addictive disorders, schizophrenia, psychosis, and tinnitus.
    Type: Application
    Filed: September 3, 2013
    Publication date: March 6, 2014
    Inventor: Daryl W. HOCHMAN
  • Publication number: 20140066505
    Abstract: The present invention relates to the use of certain dialkyl fumarates for the preparation of pharmaceutical preparations for use in transplantation medicine or for the therapy of autoimmune diseases and said compositions in the form of micro-tablets or pellets. For this purpose the dialkyl fumarates may also be used in combination with conventional preparations used in transplantation medicine and immunosuppressive agents, especially cyclosporines.
    Type: Application
    Filed: March 13, 2013
    Publication date: March 6, 2014
    Applicant: Biogen Idec International GmbH
    Inventors: Rajendra Kumar JOSHI, Hans-Peter Strebel
  • Publication number: 20140066506
    Abstract: Disclosed is a method for treating macular degeneration in a mammalian subject, which includes administering to the subject in need thereof an effective amount of a 15-keto-prostaglandin compound such as 13,14-dihydro-15-keto-20-ethyl-prostaglandin F2? isopropyl ester.
    Type: Application
    Filed: November 5, 2013
    Publication date: March 6, 2014
    Applicant: SUCAMPO AG
    Inventors: Ryuji UENO, John CUPPOLETTI
  • Publication number: 20140066507
    Abstract: The present disclosure is directed generally to cosmetic compositions comprising EPA free acid and salicylic acid. In some embodiments, the cosmetic compositions have a cosmetically acceptable odor.
    Type: Application
    Filed: May 31, 2013
    Publication date: March 6, 2014
    Applicant: Dignity Sciences Limited
    Inventors: Mehar Manku, John Climax, David Coughlan
  • Publication number: 20140066508
    Abstract: A method for ameliorating metabolic syndrome may include administering, to a patient in need thereof, an effective amount of a monounsaturated fatty acid having 22 carbons or a salt or an ester thereof and/or an effective amount of a monounsaturated fatty acid having 20 carbons or a salt or an ester thereof.
    Type: Application
    Filed: February 29, 2012
    Publication date: March 6, 2014
    Applicant: NIPPON SUISAN KAISHA, LTD.
    Inventors: Zhi-hong Yang, Hiroko Miyahara, Shuhei Takemura, Akimasa Hatanaka
  • Publication number: 20140066509
    Abstract: The present disclosure is directed generally to cosmetic compositions comprising EPA free acid and GLA free acid. In some embodiments, the cosmetic compositions have a cosmetically acceptable odor.
    Type: Application
    Filed: September 6, 2013
    Publication date: March 6, 2014
    Applicant: DIGNITY SCIENCES LIMITED
    Inventors: Mehar Manku, John Climax, David Coughlan
  • Publication number: 20140066510
    Abstract: A simple and efficient method for the production of stable, clear, high-potency oat extracts is disclosed. The method employs the use of differential dissociation constants and ultrafiltration to stabilise extracts, prevent hazing, and prevent the loss of functional activity as an anti-irritant and anti-oxidant. Also disclosed are compositions of oat extracts derived from whole oat grains and oatmeal. Further disclosed are compositions of oat extracts for use in cosmetic, nutraceutical, therapeutic medical and veterinary preparations.
    Type: Application
    Filed: August 2, 2013
    Publication date: March 6, 2014
    Inventors: Mark J. Redmond, David A. Fielder
  • Publication number: 20140066511
    Abstract: A preparation is disclosed for producing enhanced blood flow in tissue thus causing beneficial effects such as promoting hair growth on scalp tissue lacking sufficient hair, restoring normal sexual function in males with erectile dysfunction. Specifically, this is a preparation which provides local delivery of the amino acid L-arginine, an important biological precursor to the main substance which is responsible for relaxation of blood vessels permitting enhancement of blood flow. In the preferred embodiments, the L-arginine is provided so that it can be topically applied to the scalp or penis. The preparation also contains an agent which aids in the transfer of L-arginine into the tissue. In the preferred embodiments this agent overcomes the resistance to transfer caused by the high charge density of L-arginine. In the preferred embodiments this means is high ionic strength created by addition of choline chloride, magnesium chloride and sodium chloride.
    Type: Application
    Filed: October 30, 2013
    Publication date: March 6, 2014
    Applicant: Strategic Science & Technologies, LLC
    Inventor: Eric T. Fossel
  • Publication number: 20140066512
    Abstract: The present invention relates to rehydration and nutritional products comprising creatine and/or its salts, or analogues or precursors thereof, in ready to use aqueous oral compositions, such as gels, pastes and the like, and products for reconstitution in water, for use by humans and animals, together with processes for their preparation and uses thereof.
    Type: Application
    Filed: May 1, 2012
    Publication date: March 6, 2014
    Applicant: PATENTNAV IRELAND LTD
    Inventor: Edward O'Gorman
  • Publication number: 20140066513
    Abstract: A method for a prevention and/or treatment of irritable bowel syndrome or amelioration of a symptom thereof in a subject, comprises administering to said subject an effective amount of a compound of formula I:
    Type: Application
    Filed: August 26, 2013
    Publication date: March 6, 2014
    Applicant: MediciNova, Inc.
    Inventors: Kazuko MATSUDA, Yuichi Iwaki, Kale Ruby
  • Publication number: 20140066514
    Abstract: Veterinary compositions are described for controlling ecto- and endo-parasites in animals, such as bovine. The compositions contain an IGR compound(s) or a benzoyl substituted urea(s) along with a mineral mix and at least one carrier.
    Type: Application
    Filed: October 10, 2012
    Publication date: March 6, 2014
    Applicant: CHAMPION FARMOQUIMICO LTDA.
    Inventor: Flávio Alves da Rocha
  • Publication number: 20140066515
    Abstract: The present invention is directed to the use of a class of peptide compounds for treating diseases associated with hyperexcitability. The present invention is also directed to the use of a class of peptide compounds for treating diseases associated with dysfunction of an ion channel.
    Type: Application
    Filed: September 10, 2013
    Publication date: March 6, 2014
    Applicant: UCB Pharma GmbH
    Inventors: Cara Heers, Thomas Stoehr, Bettina Beyreuther
  • Publication number: 20140066516
    Abstract: The present invention is directed to a novel method for reducing intrapatient variability in pharmaceutically active agent which is suitably not absorbed in the stomach, such as paracetamol, containing formulations in patients having gastric dysmotility, or a method of improving analgesia in a diabetic patient, or improving absorption of an active agent is a patient with gastric dysmotility, which methods comprises administering orally to said patient in need thereof a pharmaceutical dosage form comprising a first active agent, calcium carbonate, at least one first binding agent, and at least one disintegrating agent as intragranular components in the form of a granulate, and as an extragranular component at least one hydrophilic colloid, an optionally a second binding agent, calcium carbonate, a super disintegrant, and a second active agent.
    Type: Application
    Filed: November 6, 2013
    Publication date: March 6, 2014
    Applicant: GLAXOSMITHKLINE, LLC
    Inventors: Geoffrey Douglas Clarke, Timothy James Grattan, Ian Burnett
  • Publication number: 20140066517
    Abstract: A product comprising a calixarene for its use in the treatment of pathologies involving at least one bacterial strain having a resistance to at least one defined antibiotic, on patients undergoing simultaneous or sequential treatment with a given antibiotic to which said bacterial strain optionally has a resistance.
    Type: Application
    Filed: April 11, 2012
    Publication date: March 6, 2014
    Inventors: Marion Grare, Raphaël Emmanuel Duval
  • Publication number: 20140066518
    Abstract: The present invention relates to ambroxol hydrochloride for the treatment of acute pharyngitis, wherein ambroxol hydrochloride as a sprayable composition comprising up to 30 mg/ml ambroxol hydrochloride is administered locally in a dose of 1 to 20 mg.
    Type: Application
    Filed: March 13, 2012
    Publication date: March 6, 2014
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Sandra Sauerland, Julia Elisabeth Boni, Bernd Karl Plohmann
  • Publication number: 20140066519
    Abstract: Method for the prevention and/or control of liver diseases, such as non-alcoholic steatohepatitis (NASH) even when eating a high fat diet. Prevention of NASH can be accomplished by preventing the liver from becoming a fatty liver even when eating a high fat diet by providing xanthohumol as a supplement to the high fat diet.
    Type: Application
    Filed: November 7, 2013
    Publication date: March 6, 2014
    Applicant: FLAXAN GMBH & CO. KG
    Inventor: Claus HELLERBRAND
  • Publication number: 20140066520
    Abstract: Disclosed is a pharmaceutical composition including a therapeutic quantity of a COX-2 inhibitor having an IC50-WHMA COX-2/COX-1 ratio ranging from about 0.23 to about 3.33 with reduced gastrointestinal and cardiovascular toxicity. Also disclosed are methods for treating osteoarthritis, rheumatoid arthritis or acute pain with less side-effects and faster onset of action utilizing the disclosed pharmaceutical composition.
    Type: Application
    Filed: November 5, 2013
    Publication date: March 6, 2014
    Applicant: METAPROTEOMICS, LLC
    Inventor: Eric Hauser KUHRTS
  • Publication number: 20140066521
    Abstract: The present invention relates to an antibacterial and/or preserving composition which contains 3-butoxy-1,2-propanediol as a preserving agent. The antibacterial or preserving composition according to the present invention has an excellent resistance to microorganisms and has an excellent moisturizing effect, and hardly causes skin troubles.
    Type: Application
    Filed: November 4, 2011
    Publication date: March 6, 2014
    Applicant: LG HOUSEHOLD & HEALTH CARE LTD.
    Inventors: Min-Ji Gu, Jung-Jin Choi, Gug-In Jeong, Sug-Youn Chang
  • Publication number: 20140066522
    Abstract: The subject application provides for an emulsion comprising an amount of a perfluorocarbon liquid dispersed as particles within a continuous liquid phase, wherein the dispersed particles have a monomodal particle size distribution and uses thereof. The subject application also provides for a method of manufacturing a perfluorocarbon emulsion, a process for preparing a pharmaceutical product containing a PFC emulsion and a process for validating a batch of an emulsion for pharmaceutical use.
    Type: Application
    Filed: August 27, 2013
    Publication date: March 6, 2014
    Applicant: OXYGEN BIOTHERAPEUTICS, INC.
    Inventors: Richard Kiral, Deborah P. Thompson, Gary L. Clauson
  • Publication number: 20140066523
    Abstract: The invention provides moldable drug delivery carriers made up of a suspension of a solid phase and an organic liquid phase for the sustained release of a therapeutic agent. The invention also provides multiphase drug delivery systems made up of a granular hydrophobic solid phase, an organic liquid phase and a hydrogel, for sustained drug delivery at varying rates over the life of the composition.
    Type: Application
    Filed: May 1, 2012
    Publication date: March 6, 2014
    Applicant: ABYRX, Inc.
    Inventors: David Knaack, Ankur Gandhi, Jordan Katz, Marci Wirtz, Richard L. Kronenthal
  • Publication number: 20140066524
    Abstract: The present disclosure relates generally to compositions for cosmetic or pharmaceutical application. The compositions include a carrier and rheology modulators.
    Type: Application
    Filed: November 13, 2013
    Publication date: March 6, 2014
    Applicant: Foamix Ltd.
    Inventors: Dov Tamarkin, Elana Gazal, Yohan Hazot, David Schuz, Irakliy Papiashvili
  • Publication number: 20140066525
    Abstract: Mixed alcohols are produced from syngas. The syngas is provided to a catalyst in a reactor at selected temperatures and pressures. Reactive products, including mixed alcohols, are removed from the reactor. Non-reactive components are removed from the mixed alcohols of their reaction products. At least part of the non-reactive components are reintroduced in the reactor along with syngas. The non-reactive components are a solvent or a super critical fluid. The non-reactive components can be reintroduced into the reactor with reactive components such as methanol or CO2.
    Type: Application
    Filed: February 26, 2013
    Publication date: March 6, 2014
    Inventors: Peter J. Tijm, Faisal Baksh
  • Publication number: 20140066526
    Abstract: A method of converting carbon containing compounds such as coal, methane or other hydrocarbons into a liquid hydrocarbon fuel utilizes a high pressure, high temperature reactor which operates upon a blend of a carbon compound including CO2 and a carbon source, a catalyst, and steam. Microwave power is directed into the reactor. The catalyst, preferably magnetite, will act as a heating media for the microwave power and the temperature of the reactor will rise to a level to efficiently convert the carbon and steam into hydrogen and carbon monoxide.
    Type: Application
    Filed: October 30, 2013
    Publication date: March 6, 2014
    Applicant: ECOKAP TECHNOLOGIES LLC
    Inventor: Ronald Kyle
  • Publication number: 20140066527
    Abstract: A process wherein synthesis gas is reacted to produce desired products, such as alcohols, and wherein by-products, such as methane, are reformed to provide hydrogen and carbon monoxide that is recycled to the feed of synthesis gas. The process also may provide for the recycle of unreacted hydrogen and unreacted carbon monoxide to the feed of synthesis gas.
    Type: Application
    Filed: February 21, 2013
    Publication date: March 6, 2014
    Inventors: Melissa Gaucher, Louis Denomme, Gregory Carr
  • Publication number: 20140066528
    Abstract: A graft chain containing an N-vinylimidazole derivative is introduced into a polymer substrate by radiation graft polymerization to obtain an alkyl substituted imidazolium salt by a reaction with an alkyl halide, so that an anion exchange membrane with high alkaline durability, in which a nucleophilic substitution reaction and an elimination reaction are inhibited, is obtained.
    Type: Application
    Filed: August 28, 2013
    Publication date: March 6, 2014
    Applicants: Daihatsu Motor Co., Ltd., Japan Atomic Energy Agency
    Inventors: Kimio YOSHIMURA, Hiroshi KOSHIKAWA, Tetsuya YAMAKI, Masaharu ASANO, Yasunari MAEKAWA, Hideyuki SHISHITANI, Koichiro ASAZAWA, Susumu YAMAGUCHI, Hirohisa TANAKA
  • Publication number: 20140066529
    Abstract: Silica polyamine composites (SPC) made from silanized amorphous nano-porous silica gel and poly(allylamine) (BP-1) were functionalized with phosphorus acid using the Mannich reaction, resulting in a phosphonic acid modified composite (BPAP). Zirconium (IV) was immobilized on BPAP. Arsenate anions strongly adsorbed on the ZrBPAP composite in the pH range 2 to 8, while arsenite only adsorbed well at pH 10. Regeneration of the resin was carried out successfully for As(V) and As(III) using 2M-H2SO4. Four adsorption/desorption cycles were performed for As(V) at pH 4 without significant decrease in the uptake performance. ZrBPAP capture capacity and kinetics for arsenate were tested for longevity over 1000 cycles with only a marginal loss of performance.
    Type: Application
    Filed: November 6, 2013
    Publication date: March 6, 2014
    Applicant: The University of Montana
    Inventors: Edward Rosenberg, Varadharajan Kailasam, Daniel Nielsen