Abstract: The present invention provides nucleic acid amplification systems and methods that desirably reduce or eliminate false positive amplification signals resulting from contaminating biological material, e.g., nucleic acid, that may be present in one or more reagents used in an amplification reaction and/or that may be present in the environment in which an amplification reaction is performed. The invention offers the further advantage of requiring less stringent purification and/or sterility efforts than conventionally needed in order to ensure that enzymes and other reagents used in amplification reactions, and the environment in which an amplification reaction is performed, are free of bacterial or other nucleic acid contamination that may yield false positive results.

Abstract: A Positional Scanning-Synthetic Peptide Combinatorial Library (PS-SPC) searching apparatus and method using Surface Plasmon Resonance (SPR) are provided. The method includes spotting and fixing each of a plurality of peptide pools to a top of one thin metal film, inputting specific materials to the top of the thin metal film, applying a TM-mode light to a bottom of the thin metal film and exciting SPR for the thin metal film, and detecting a TM mode reflected light reflected from the thin metal film and displaying the detected light as a two-dimensional image.

Abstract: Methods are provided for detecting an aneuploidy in a fetus. These methods can be used to detect trisomy 13, 8 or 21, amongst other aneupoloidies. In some embodiments, the methods include selectively purifying fetal DNA from a maternal biological sample using the methylation status of a CpG containing genomic sequence and genotyping the fetus using the purified fetal DNA, thereby detecting aneuploidy in the fetus.

Abstract: The invention provides a method of printing, onto a substrate (12), an array (14) of spots of reagent compositions for use in a chemical and/or biochemical analysis. The method includes displacing an array of reagent composition containing capillary tubes (22) arranged alongside one another from an inoperative position to an operative position in which open ends of the capillary tubes (22) simultaneously impinge against a substrate and thereafter displacing the array of tubes (22) from the operative position back to the inoperative position. The invention extends to a printing apparatus (10), a method of printing a layered array of spots of reagent compositions, a method of introducing reagent compositions into the tubes, a reagent introducing device for introducing reagent compositions into the tubes and a printing installation which includes the printing apparatus (10) and the reagent introducing device.

Abstract: The present invention relates to reading-frame-correct fragment libraries, methods for their production, and the use of the fragment libraries for selection of functional polypeptide variants with improved properties.

Abstract: The present invention relates to a method for preparing a library of template polynucleotides and use thereof in methods of solid-phase nucleic acid amplification. More specifically, the invention relates to a method for preparing a library of template polynucleotides that have common sequences at their 5? ends and at their 3? ends.

Abstract: The invention combines the advantages of split and mix synthesis with the advantages of template directed synthesis. The method comprises the steps of: a) adding a linker molecule L to one or more reaction wells; b) adding a molecule fragment to each of said reaction wells; c) adding an oligonucleotide identifier to each of said reaction wells; d) subjecting said wells to conditions sufficient to allow said molecule fragments and said oligonucleotide identifiers to become attached to said linker molecule, or conditions sufficient for said molecule fragments to bind to other molecule fragments and sufficient for said oligonucleotide identifiers to bind to other oligonucleotide identifiers; e) combining the contents of said one or more reaction wells; and f) contacting the resulting bifunctional molecule(s) of step e) with one or more (oligonucleotide) templates each capable of hybridizing to at least one of the oligonucleotide identifiers added in step c).

Abstract: The invention provides a method of printing, onto a substrate (12), an array (14) of spots of reagent compositions for use in a chemical and/or biochemical analysis. The method includes displacing an array of reagent composition containing capillary tubes (22) arranged alongside one another from an inoperative position to an operative position in which open ends of the capillary tubes (22) simultaneously impinge against a substrate and thereafter displacing the array of tubes (22) from the operative position back to the inoperative position. The invention extends to a printing apparatus (10), a method of printing a layered array of spots of reagent compositions, a method of introducing reagent compositions into the tubes, a reagent introducing device for introducing reagent compositions into the tubes and a printing installation which includes the printing apparatus (10) and the reagent introducing device.

Abstract: An invert emulsion drilling fluid, and a method for the use thereof in drilling wellbores, with good rheological properties at high temperatures and pressures. One embodiment of the drilling fluids is free of organophilic clays and lignites, free of calcium chloride, and comprises glycerol in the internal phase, and a suspension agent comprising a combination of a fatty dimer diamine and a short chain acid, such as citric acid. In one embodiment, the base oil for the emulsion is a paraffin and/or mineral oil. The drilling fluids provide good rheological properties including good suspension of drill cuttings.

Abstract: Various salt crystal and agglomeration settling inhibiting agents may aid the ability to keep salt crystals of a desired particle size undissolved and dissolved in an aqueous drilling fluid, including, whey, wine-making residues, “steepwater solubles” or an organic liquid formed from the residue of wet processing of grains, sugar cane, sugar beets, and similar plants for the food and beverage industries for consumption by human or animals, and combinations thereof. A fluid so treated has more uniform properties and a reduced tendency for the salt therein to settle out as compared to an otherwise identical fluid absent an effective proportion or amount of the salt crystal agglomeration and settling inhibiting agent, even for saturated salt fluids. The salt crystal agglomeration and settling inhibiting agents are also believed to be useful in inhibiting or preventing the formation of gas hydrates under gas hydrate forming conditions of low temperature and high pressure.

Abstract: Viscosifying compositions having reduced toxicity are used in treatment fluids in subterranean operations; methods include providing such treatment fluids including a viscosifying composition and an aqueous base fluid, the viscosifying composition including hydroxyethyl cellulose, about 10% to about 60% by weight of 2-pyrrolidone, and about 10% to about 60% by weight of a water soluble monoalkyl ether of propylene glycol having substantially no swelling effect on the hydroxyethyl cellulose, wherein a weight ratio of hydroxyethyl cellulose to 2-pyrrolidone is in a range from about 1:2 to about 2.6:1 and the method including placing the treatment fluid in a subterranean formation.

Abstract: A method to control viscosity with respect to shear rate for an oil based drilling fluid by adding a polyamide drilling fluid additive to the oil based drilling fluid. In some embodiments, a polyamide drilling fluid additive includes a reaction product of (i) a carboxylic acid with a single carboxylic moiety or two carboxylic moieties, and (ii) a polyamine having an amine functionality of two or more; and placing the placing the oil based drilling fluid into the subterranean formation.

Abstract: Treatment fluids comprising an aqueous fluid and a low-leakoff particulate, wherein the low-leakoff particulate comprises a low molecular weight modified polysaccharide that has been crosslinked with a crosslinking agent wherein the low molecular weight modified polysaccharide contains one or more of the following monosaccharide units: galactose, mannose, glucoside glucose, xylose, arabinose, fructose, glucuronic acid, or pyranosyl sulfate.

Abstract: A polymer-brush-based, surface-modification strategy for friction and wear reduction in hard contact under boundary-lubrication conditions is proposed, specifically for a non-aqueous environment. Surface-initiated Atom Transfer Radical Polymerisation (SI-ATRP) was employed for the synthesis of three different oil-compatible, hydrophobic polymer brushes based on alkyl methacrylates. This study presents polymerisation kinetics, chemical characterization by means of Fourier transform infrared spectroscopy (FTIR) and surface morphologies observed in atomic force microscopy (AFM). The lubrication properties of the anchored polymers were evaluated macroscopically by means of ball-on-disk methods and on the nanonewton scale by lateral force microscopy (AFM/LFM) and showed significant reduction in friction up to contact pressures as high as 460 MPa. The frictional response of surface-grafted polymers is shown to depend strongly on the compatibility of the polymer with the chosen lubricating fluid.

Abstract: A method for producing a high viscosity, low volatiles blown stripped plant-based oil is provided. The method may include the steps of (i) obtaining a plant-based oil; (ii) heating the oil to at least 90C; (iii) passing air through the heated oil to produce a blown oil having a viscosity of at least 200 cSt at 40C; (iv) stripping the blown oil from step (iii) to reduce an acid value of the blown oil to from 5 mg KOH/g to about 9 mg KOH/g; (v) adding a polyol to the stripped oil from (iv); and (vi) stripping the oil from step (v) to reduce the acid value of the oil to less than 5.0 mg KOH/g or less.

Abstract: The invention provides a lubricating composition containing an oil of lubricating viscosity, an additive containing a polymeric backbone and at least one amino group. The invention further provides for the additive to have dispersant and/or dispersant viscosity modifying properties. The lubricating composition is suitable for lubricating an internal combustion engine.

Abstract: The present disclosure relates to a non-acidic, sulfur-containing, phosphorus-containing compound of the formula I where R1, R2, R3, R4, R5, R6, and R7 are as defined herein. Such a compound may exhibit improved antiwear performance and thermal stability in lubricating compositions.

Abstract: The present disclosure is directed to compositions having lecithin and an organic acid and related methods. The disclosed compositions may also include one or more co-surfactants such as anionic surfactants and/or non-ionic surfactants, and may be used as a dispersant.

Abstract: An erasure fluid includes a vehicle, an erasure component incorporated into the vehicle, and a polymer. The erasure component interacts with a selected colorant of an erasable inkjet ink printed on a medium to erase the inkjet ink from the medium, and is chosen from persulfate ions, peroxymonosulfate ions, hydrogen peroxide, chlorate ions, hypochlorite ions, ascorbic acid, and a chelating agent. Further, the polymer is chosen from carboxymethylcelluloses, methyl celluloses, polyethylene glycols, guar gum, starches, and combinations thereof.

Abstract: A particulate coke composition including expandable coke is capable of removing deposits from rotating parts of a gas turbine engine while under full fire or idle speed. The coke composition may be introduced directly into the combustion chamber (combustor) of the gas turbine or, alternatively, anywhere in the fuel stream, water washing system, or the combustion air system. By kinetic impact with the deposits on blades and vanes, the deposits will be dislodged and will thereby restore the gas turbine to rated power output. If introduced into the compressor section, the coke particles impinge on those metal surfaces, cleaning them prior to entering the hot gas section where the process is repeated.

Abstract: An aqueous aerosol bathroom cleaner includes a surfactant, a water-soluble or dispersible organic solvent, a chelating agent and a propellant that comprises n-butane. Comparative data demonstrate that the presence of n-butane in the composition enhances the rate of bathroom soap scum removal relative to aerosol compositions that do not contain n-butane in the propellant. The amount of surfactant present is sufficient so that the composition, develops a stable foam upon being dispensed onto a soiled bathroom hard surface. The foam collapses after 10 to 60 seconds to deliver the cleaning components onto the surface.

Abstract: This invention refers to a stabilized pipe scaling remover and inhibitor compound, where a useful formulation is presented for the dissolution of scaling such as barium sulfate, calcium sulfate, calcium carbonate, magnesium carbonate, barium carbonate and ferric oxide. This formulation is made up by a stabilized group of organic and inorganic acids, in addition to amines or alcohols of a high molecular weight which make it a low-corrosion, highly-effective fluid. The possible fluids to be obtained from this document ensure the least amount of damage to the pipes used for its transportation and are friendly to different polymer materials. They progressively attack buildup scaling by solubilizing it in an aqueous medium and breaking down the carbonate ion. Its use in the oil industry is as scale inhibitor, inorganic scale inhibitor, or scale formation inhibitor (when applied in solution).

Abstract: The present invention relates to a laundry detergent or a cleaning composition, preferably a granular detergent product, comprising a carboxyl-group containing polymer, which is useful in improving whiteness and/or anti-soil redeposition. Processes for making and methods of using the laundry detergent or cleaning composition are also encompassed by the present invention.

Abstract: The present invention relates to a cleaning composition, preferably a granular detergent product, comprising a carboxyl-group containing polymer, which is useful in improving whiteness and/or anti-soil redeposition. Processes for making and methods of using the cleaning composition are also encompassed by the present invention.

Abstract: A synergistic mixture for promoting soil release from fabric, under laundry washing conditions, which comprises a polyacrylate polymer and at least one water soluble modified cellulose ether. The polyacrylate polymer comprises: (i) 90-100 weight % of polymerized units derived from acrylic acid and (ii) up to 10 weight % of polymerized units derived from one or more C3-C8 monoethylenically unsaturated carboxylic acids, based on the total weight of said polyacrylate polymer. A laundry formulation is also provided which contains the synergistic mixture in an amount of up to 2 weight %, based on the total weight of the laundry formulation. Also provided are methods of promoting soil release from soiled fabric which involve contacting the soiled fabric with an aqueous solution comprising the above-described inventive synergistic mixture or with the above-described laundry formulation.

Abstract: Detergent compositions including at least one AMPS copolymer, at least one organophosphonate, an alkaline agent, free of acrylic homopolymer, and an optional complexing agent are disclosed. Embodiments of the present invention reduce scale accumulation and provide stain removal capability for warewash applications.

Abstract: A hard surface cleaning solution having improved cleaning and descaling properties. The cleaning solution includes the following components: a first organic acid, a second organic acid, a surfactant, a solvent and a diluent. The first organic acid is a carboxylic acid, preferably lactic acid, while the second organic acid is also a carboxylic acid, preferably gluconic acid. The surfactant is selected from the group consisting of amine oxides, preferably lauramine oxide. The solvent may be an alkoxylated alcohol, preferably selected from the propylene glycol ether class of compounds.

Abstract: A process is disclosed to make polyurea microcapsules containing fragrance oil. The microcapsules are heat stable such that the fragrance substantially remains when the microcapsules are exposed for 1 hour at a temperature of from about 190° F. to about 240° F.

Abstract: The present invention provides an alcohol-based stable and translucent fragrance composition containing a large amount of perfume. The fragrance composition of the present invention is a composition in which the total amount of (a) silicone oil and (b) ?-olefin oligomer that is a hydrogenated trimer, tetramer, pentamer, and/or hexamer of ?-olefin having 4 to 12 carbon atoms is 2 to 12% by mass in the composition, and the mass ratio of (b)/(a) is 0.1 to 0.7; the amount of (c) polyether-modified silicone with respect to (b) ?-olefin oligomer is 2 to 10 times in mass; the amount of (d) perfume is 3 to 30% by mass in the composition; the amount of (e) lower alcohol having 1 to 4 carbon atoms is 50% by mass or more in the composition; the amount of (f) water is 3.5 to 15% by mass in the composition; and the L value of the composition is 70 to 95 provided the L value is a percentage (%) of strength of a transmitted light compared with a strength of an incident light.

Abstract: According to a first aspect, hydrolysis of a protein-containing raw material and separation of amino acids/peptides is carried out, wherein the hydrolysis is effected by using the endogenous enzymes of the protein-containing raw material. The hydrolysate is passed through a membrane filter, wherein peptide/amino acids follow a permeate stream, whilst the active enzymes continuously break down any protein residues that are deposited on the membrane surface. The enzymes are passed together with retentate back to the hydrolysis. Furthermore, an amino acid and peptide product and an oil product are described and the use thereof is disclosed.

Abstract: The present invention provides uses and methods of using a sema3E polypeptide and a sema3e polynucleotide encoding a sema3E polypeptide. The methods include decreasing airway remodeling in a subject, treating asthma in a subject, treating a subject having, or at risk of having, acute asthma, and reducing inflammation of a subject's airway. The methods also include evaluating treatment options for a subject having asthma and diagnosing whether a subject has asthma.

Abstract: Peptides useful as angiotensin converting enzyme inhibitors are provided. Also provided are compositions comprising one or more of the peptides and methods for preventing, treating and/or diminishing one or more syndromes associated with angiotensin converting enzyme by using the peptides.

Abstract: The invention provides materials and methods for treating infections by reducing endogenous microbial H2S levels.

Abstract: A nanoparticle includes a carbohydrate carrier and a bacteriocin. A method for prolonging efficacy of a bacteriocin against a food pathogen includes providing the bacteriocin in a delivery system, and inhibiting the food pathogen by the bacteriocin. A duration of efficacy of the bacteriocin against the food pathogen when the bacteriocin is provided in the delivery system exceeds a duration of efficacy of the bacteriocin when the bacteriocin is provided without the delivery system.

Abstract: A tissue adhesive including cyanoacrylate and polyethylene glycol (PEG), wherein the PEG remains a polyether and wherein the tissue adhesive is bioabsorbable. A tissue adhesive including cyanoacrylate bulk monomer and cyanoacrylate nanoparticles containing a therapeutic therein. A kit for applying tissue adhesive, including the tissue adhesive described above and an applicator. Methods of accelerating degradation of a cyanoacrylate tissue adhesive applying a tissue adhesive, closing an internal wound, administering a therapeutic to tissue, treating cancer, and preventing infection in a wound. Methods of method of making a bioabsorbable tissue adhesive and making a therapeutic tissue adhesive.

Abstract: A product comprising at least one given antibiotic and a calixarene for use as medicament.

Abstract: There is provided a biologically-active agent, in particular, for the early diagnosis and/or preventative therapy of virally-infected living cells, the efficacy of which is selective for the cell membranes of the virally-infected cells, which are modified after viral infection. The agent includes at least one component, selected from a group of materials, including recombinant human histone H1 or at least an H1 subtype or the active portion thereof. The appropriate biological activity for killing a virally-infected cell at the modified cell membrane thereof through cooperation with similarly or differently active agent components may be achieved, which together form a biologically-effective complex with increased biological activity.

Abstract: This document provides methods and material related to natriuretic polypeptides. For example, substantially pure polypeptides having a natriuretic peptide activity, nucleic acids encoding polypeptides having a natriuretic peptide activity, host cells containing such nucleic acids, and methods for inducing a natriuretic or diuretic activity within a mammal are provided.

Abstract: Methods for affecting body composition include the use of amylin or amylin agonist(s). Total body weight be reduced, maintained or even increased; however, the body fat is reduced or body fat gain is prevented, while lean body mass is maintained or increased.

Abstract: The present invention relates to compounds of Formula I and pharmaceutically acceptable salts, solvates, and hydrates thereof, that are useful as single pharmaceutical agents or in combination with one or more additional pharmaceutical agents, such as, a DPP-IV inhibitor, a biguanide, an alpha-glucosidase inhibitor, an insulin analogue, a sulfonylurea, an SGLT2 inhibitor, a meglitinide, a thiazolidinedione, or an anti-diabetic peptide analogue, in the treatment of for example, a disorder selected from: a GPR119-receptor-related disorder; a condition ameliorated by increasing a blood incretin level; a condition characterized by low bone mass; a neurological disorder; a metabolic-related disorder; type 2 diabetes; obesity; and complications related thereto.

Abstract: The disclosure provides Polypeptide Conjugates with multiple improved pharmacological and pharmacokinetic properties and their use in treating various diseases and conditions, such as diabetes and/or obesity.

Abstract: The present invention relates to methods and pharmaceutical compositions relating to administering hypoglycemic agents and/or GLP-1 agonists wherein the mean maximum plasma concentration (Cmax) and/or Area Under the Curve (AUC) values of the hypoglycemic agent are increased and/or sustained.

Abstract: The present invention relates to pharmaceutical compositions comprising {2-[3-cyclohexyl-3-(trans-4-propoxy-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid (FRI-1) in combination with an anti-diabetic drug selected from the group consisting of metformin, sitagliptin or exenatide. The present invention also relates to the use of the pharmaceutical compositions in restoring insulin sensitivity and treating type II diabetes, including reducing body weight in subjects undergoing type II diabetes treatment.

Abstract: Methods are provided of treating or preventing diabetes in a subject comprising administering to the subject an amount of oxytocin or an oxytocin analog. Methods are also provided of increasing insulin secretion in a subject comprising administering to the subject an amount of oxytocin or an oxytocin analog.

Abstract: The compositions and methods of the present invention relate to the co-delivery of a molecule and a polypeptide to cells to improve the therapeutic efficacy of the molecules. In one embodiment of the invention, the invention may improve delivery of growth factors by co-delivering these growth factors with their receptors and co-receptors, such as syndecans. Co-delivery of growth factors with syndecans, for example, may protect growth factors from proteolysis, enhance their activity, and target the growth factors to the cell surface to facilitate growth factor signaling. This novel approach to growth factor therapy could be extended to other systems and growth factors enabling the enhancement of multiple signaling pathways to achieve a desired therapeutic outcome.

Abstract: The present invention relates to a novel endocytic motif, and in particular, to a fusion polypeptide including the motif represented by an amino acid sequence of SEQ ID NO. 1 and a protein transduction domain, a pharmaceutical composition for preventing or treating cancer including the same, and a method for treating cancer including the step of administering the composition. The present invention shows the effects of suppressing metastasis, infiltration, angiogenesis, and growth of cancer by specifically inhibiting c-Met endocytosis and effectively inhibiting HGF/c-Met signaling pathway associated with metastasis and growth of various types of cancer cells. Therefore, the present invention can be applied to an anticancer agent for various types of cancer.

Abstract: Provided herein are compositions and methods related to promoting protection or repair of articular cartilage and/or musculoskeletal soft tissue by contacting the cartilage, tissues or cellular components thereof with a parathyroid hormone/parathyroid hormone-related protein (PTH/PTHrP) receptor agonist or releasing factor.

Abstract: The present disclosure relates to methods of modulating aquaporin channels. Particularly, the disclosure provides methods of modulating aquaporin channels in a tissue of a mammal by administering relaxin.

Abstract: Provided herein are multifunctional heteromultimer proteins. In specific embodiments is a heteromultimer comprising: at least two polypeptide constructs, each polypeptide construct comprising at least one cargo polypeptide attached to a transporter polypeptide, said transporter polypeptides derived from a monomeric native protein such that said monomeric constructs associate to form the heteromultimer and said transporter polypeptides associate to form a quasi-native structure of the monomeric native protein or analog thereof. These therapeutically novel molecules encompass heteromultimers comprising constructs that function as scaffolds for the conjugation or fusion of therapeutic molecular entities (cargo polypeptides) resulting in the creation of bispecific or multivalent molecular species. Provided herein is a method for creation of bispecific or multivalent molecular species.

Abstract: A recombinant vector, transgenic fish egg using the same and biomaterial using the same are applied to provide a transgenic fish that secreting recombinant human procollagens or collagens, and further to provide the biomaterial having the recombinant human procollagens or collagens and extract the recombinant human procollagens or collagens from the part(s), having the recombinant human procollagens or collagens, of the transgenic fish.