Patents Issued in July 15, 2014
  • Crystal of fused pyridine compound salt
    Patent number: 8779140
    Abstract: [Problem] A salt or crystal of a compound which is highly stable in a solid state and useful as a bulk material for the preparation of a pharmaceutical product is provided. [Means for Solution] 4-{[(1R,2s,3S,5s,7s)-5-Hydroxy-2-adamantyl]amino}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide succinate, 4-{[(1R,2s,3S,5s,7s)-5-hydroxy-2-adamantyl]amino}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrobromide, and 4-{[(1R,2s,3S,5s,7s)-5-hydroxy-2-adamantyl]amino}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrochloride and crystals thereof are useful as a bulk material for the preparation of a solid preparation, in particular, a solid dispersion preparation. Furthermore, the crystal of the hydrobromide has excellent stability in a solid state and is useful as a bulk material for the preparation of a pharmaceutical product.
    Type: Grant
    Filed: June 22, 2011
    Date of Patent: July 15, 2014
    Assignee: Astellas Pharma Inc.
    Inventors: Takashi Kikuchi, Katsuhiko Gato, Koichiro Mukoyoshi, Tsuyoshi Kitamura, Takeshi Kawakami, Hironobu Yasuda
  • Viral inhibitors
    Patent number: 8779141
    Abstract: The present invention relates to imidazo[4,5-c]pyridine compounds and pharmaceutical compositions for the treatment or prevention of viral infections, wherein the imidazo[4,5-c]pyridine compounds have the formula:
    Type: Grant
    Filed: May 19, 2009
    Date of Patent: July 15, 2014
    Assignees: Gilead Sciences, Inc., K.U. Leuven Research & Development, Gerhard Puerstinger
    Inventors: Johan Neyts, Gerhard Pürstinger, Erik De Clercq
  • Azabicyclo compound and salt thereof
    Patent number: 8779142
    Abstract: It is intended to provide a novel azabicyclo compound which exhibits both HSP90 inhibitory activity and cell proliferation inhibitory effect. Specifically disclosed is a compound represented by the following general formula (I) or a salt thereof: wherein X1 represents CH or N; any one of X2, X3 and X4 represents N, and the others represent CH; any one or two of Y1, Y2, Y3 and Y4 represent C—R4, and the others are the same or different and represent CH or N; R1 represents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, S and O; R2 represents an alkyl group having 1 to 6 carbon atoms, or the like; and R3 and R4 represent —CO—R5 or the like.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: July 15, 2014
    Assignee: Taiho Pharmaceutical Co., Ltd.
    Inventors: Makoto Kitade, Shuichi Ohkubo, Chihoko Yoshimura, Satoshi Yamashita, Hiromi Oshiumi, Takao Uno, Yuichi Kawai
  • Crystalline forms of maraviroc phosphate and process for maraviroc amorphous form
    Patent number: 8779143
    Abstract: The present invention provides novel crystalline forms of maraviroc phosphate, processes for their preparation and pharmaceutical compositions comprising them. The present invention also provides novel process for the preparation of maraviroc amorphous form and pharmaceutical composition comprising it.
    Type: Grant
    Filed: August 30, 2010
    Date of Patent: July 15, 2014
    Assignee: Hetero Research Foundation
    Inventors: Bandi Parthasaradhi Reddy, Kura Rathnakar Reddy, Dasari Muralidhara Reddy, Rapolu Raji Reddy, Kesireddy Subash Chander Reddy, Bandi Vamsi Krishna
  • Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
    Patent number: 8779144
    Abstract: Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: July 15, 2014
    Assignee: Evotec (US) Inc.
    Inventors: Michael G. Kelly, John Kincaid, Yeyu Cao, Carl Kaub, Sumithra Gowlugari, Jianhua He
  • Process for the preparation of 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline
    Patent number: 8779145
    Abstract: Industrially applicable process for preparing 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide, and salts thereof.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: July 15, 2014
    Assignee: Sanofi
    Inventor: Steven Elenbaas
  • Cilostazol cocrystals and compositions
    Patent number: 8779146
    Abstract: The invention relates to improvements of the physiochemical and/or the pharmaceutical properties of cilostazol. Disclosed herein are several new compositions and cocrystals of cilostazol, including: a 1:1 cilostazol gentisic acid cocrystal, a 1:1:1 cilostazol gentisic acid H2O cocrystal, a 1:1 cilostazol 4-hydroxybenzoic acid cocrystal, and a 1:1 cilostazol 2,4-dihydroxybenzoic acid cocrystal. The therapeutic methods and uses of these cilostazol cocrystals are described as well as therapeutic compositions containing them.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: July 15, 2014
    Assignee: Nuformix Limited
    Inventors: Alan Chorlton, Christopher Frampton, Daniel Gooding, Joanne Holland
  • 3,4-disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinase and glycogen synthase kinase-3 modulators
    Patent number: 8779147
    Abstract: The invention provides compounds of the formula (0) or salts or tautomers or N-oxides or solvates thereof, and combinations thereof with other anti-cancer agents, for use in the prophylaxis or treatment of disease states and conditions such as cancers mediated by cyclin-dependent kinase and glycogen synthase kinase-3.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: July 15, 2014
    Assignee: Astex Therapeutics, Ltd.
    Inventors: Valerio Berdini, Michael Alistair O'Brien, Maria Grazia Carr, Theresa Rachel Early, Adrian Liam Gill, Gary Trewartha, Alison Jo-Anne Woolford, Andrew James Woodhead, Paul Graham Wyatt
  • Fluoro-pyridinone derivatives useful as antibacterial agents
    Patent number: 8779148
    Abstract: The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.
    Type: Grant
    Filed: October 31, 2013
    Date of Patent: July 15, 2014
    Assignee: Pfizer Inc.
    Inventors: Usa Reilly, Michael Joseph Melnick, Matthew Frank Brown, Mark Stephen Plummer, Justin Ian Montgomery, Ye Che, Loren Michael Price
  • Aminopyridine- and aminopyrimidinecarboxamides as CXCR2 modulators
    Patent number: 8779149
    Abstract: There is disclosed aminopyridine- and aminopyrimidinecarboxamide compounds useful as pharmaceutical agents, synthesis processes, and pharmaceutical compositions which include aminopyridine- and aminopyrimidinecarboxamides compounds. More specifically, there is disclosed a genus of CXCR2 inhibitor compounds that are useful for treating a variety of inflammatory and neoplastic disorders.
    Type: Grant
    Filed: August 22, 2011
    Date of Patent: July 15, 2014
    Assignee: Syntrix Biosystems, Inc.
    Inventors: Dean Y. Maeda, John A. Zebala, Aaron D. Schuler
  • Processes for the manufacture of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1 H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide
    Patent number: 8779150
    Abstract: According to the present invention there are provided novel processes for the manufacture of the compound of formula 1 as well as intermediates and novel synthesis routes for key intermediates used in those processes.
    Type: Grant
    Filed: July 15, 2011
    Date of Patent: July 15, 2014
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Corey James Brumsted, Hendrik Moorlag, Roumen Nikolaev Radinov, Yi Ren, Pius Waldmeier
  • Orally bioavailable caffeic acid related anticancer drugs
    Patent number: 8779151
    Abstract: The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as inhibitors of Jak2/STAT3 pathways and downstream targets and inhibit the growth and survival of cancerous cell lines.
    Type: Grant
    Filed: April 2, 2007
    Date of Patent: July 15, 2014
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Waldemar Priebe, Izabela Fokt, Slawomir Szymanski, Timothy Madden, Jeffrey Myers, Charles Conrad
  • Methods for preparing ruthenium carbene complex precursors and ruthenium carbene complexes
    Patent number: 8779152
    Abstract: A method for preparing a ruthenium carbene complex precursor includes reacting a ruthenium refinery salt with a hydrogen halide to form a ruthenium intermediate, and reacting the ruthenium intermediate with an L-type ligand to form the ruthenium carbene complex precursor. A method for preparing a ruthenium vinylcarbene complex includes converting a ruthenium carbene complex precursor into a ruthenium hydrido halide complex, and reacting the ruthenium hydrido halide complex with a propargyl halide to form the ruthenium vinylcarbene complex. A method for preparing a ruthenium carbene complex includes converting a ruthenium carbene complex precursor into a ruthenium carbene complex having a structure (PR1R2R3)2Cl2Ru?CH—R4, wherein R1, R2, R3, and R4 are alike or different, and wherein covalent bonds may optionally exist between two or more of R1, R2, and R3.
    Type: Grant
    Filed: October 13, 2011
    Date of Patent: July 15, 2014
    Assignee: Elevance Renewable Sciences, Inc.
    Inventors: Linda A. Kunz, Steven A. Cohen, Melvin L. Luetkens, Jr.
  • 3-amino-pyrazole derivatives useful against tuberculosis
    Patent number: 8779153
    Abstract: A compound of Formula (I) or a pharmaceutically acceptable salt thereof: Wherein: Het is a 5 to 10-membered heteroaromatic ring; Either X is N and Y is CR5; or X is C and Y is S; Z is selected from N and CH; R1 is selected from H and C1-2alkyl; R2 is selected from H, C1-2alkyl, OH, —CH2OH and C1-2alkoxy; Each R3 is independently selected from OH, C1-3alkyl, F, Cl, Br, NH2, and C1-3alkoxy; R4 is selected from C1-3alkyl and haloC1-3alkyl; R5 is selected from H, C1-3alkyl and haloC1-3alkyl; R6 and R7 are either i) each independently selected from H, C1-3alkyl and C1-3alkoxy; or ii) R6 and R7 together with the ring to which they are attached form a 9-membered bicylic ring; p is 0-3; and RA is selected from H and C1-3alkyl, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: July 15, 2014
    Assignee: Glaxo Group Limited
    Inventors: Julia Castro Pichel, Raquel Fernandez Menendez, Esther Pilar Fernandez Velando, Silvia Gonzalez Del Valle, Araceli Mallo-Rubio
  • Fused ring compounds for inflammation and immune-related uses
    Patent number: 8779154
    Abstract: The invention relates to certain fused ring compounds, or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
    Type: Grant
    Filed: September 25, 2007
    Date of Patent: July 15, 2014
    Inventors: Qinglin Che, Nha Huu Vo, Shoujun Chen
  • 1,2,3-triazole based metal-organic framework as photo-active materials
    Patent number: 8779155
    Abstract: A TAF compound that can have substitutions on either of the two benzene rings and/or the C-5 position of the triazole to alter the properties of the TAF compound can be wherein X can be H, an aromatic group, a hetero aromatic group, an alkyl or any substituted alkyl group, ketone, aldyhyde, carboxylic acid derivatives; Y1, Y2, Y3, Y4, and Y5 can be one or more of H, aromatic groups, hetero aromatic groups, alkyl or any substituted alkyl groups, ketone, aldyhyde, or carboxylic acid derivatives; and Z1, Z2, Z3, Z4, and Z5 can be one or more of H aromatic groups, hetero aromatic groups, alkyl or any substituted alkyl groups, ketone, aldyhyde, or carboxylic acid derivatives. Included is a preparation of the TAF compound and use as a photoactive and/or catalyst.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: July 15, 2014
    Assignee: West Virginia University
    Inventor: Xiaodong Shi
  • Analogues for the treatment or prevention of flavivirus infections
    Patent number: 8779156
    Abstract: Compounds represented by formula I or pharmaceutically acceptable salts thereof, wherein A, B, B?, X, Y, R1, R2, R2?, R3, R3?, R4, R4?, R5, R5?, m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: July 15, 2014
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sanjoy Kumar Das, Youssef L. Benanni, Laval Chan Chun Kong, John Maxwell, T. Jagadeeswar Reddy, Constantin Yannopoulos, Bingcan Liu, Caroline Cadilhac, Simon Giroux, James A. Henderson, Real Denis, Louis Vaillancourt, Oswy Z. Pereira, Carl Poisson, Guy Falardeau, Mark A. Morris
  • MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Patent number: 8779157
    Abstract: Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and use thereof.
    Type: Grant
    Filed: September 7, 2010
    Date of Patent: July 15, 2014
    Assignee: Vanderbilt University
    Inventors: P. Jeffrey Conn, Craig W. Lindsley, Corey R. Hopkins, Charles David Weaver, Colleen M Niswender, Darren W. Engers, Patrick R. Gentry, Yiu-Yin Cheung, James M. Salovich, Rocco D. Gogliotti
  • Trisubstituted pyrazoles as acetylcholine receptor modulators
    Patent number: 8779158
    Abstract: The present invention relates to 1-alkyl-3-aniline-5-aryl-pyrazole derivatives and pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I). The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.
    Type: Grant
    Filed: May 8, 2009
    Date of Patent: July 15, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Johannes Wilhelmus John F. Thuring, Gregor James MacDonald, Wei Zhuang
  • Compound or its tautomer, metal complex compound, colored photosensitive curing composition, color filter, and production
    Patent number: 8779159
    Abstract: Provided is a colored photosensitive curing composition useful for color filters in primary colors, including blue, green, and red, having a high molar absorption coefficient and allowing a reduction in film thickness and superior color purity and fastness. A colored photosensitive curing composition, comprising, as its colorant, a dipyrromethene-based metal complex compound obtained from a metal or metal compound and a dipyrromethene-based compound represented by the following Formula (I): wherein in Formula (I), R1 to R6 each independently represents a hydrogen atom or a substituent group; and R7 represents a hydrogen or halogen atom, or an alkyl, aryl or heterocyclic group.
    Type: Grant
    Filed: May 23, 2012
    Date of Patent: July 15, 2014
    Assignee: FUJIFILM Corporation
    Inventors: Yuki Mizukawa, Ryoji Goto, Hideki Takakuwa, Masashi Ogiyama, Toru Fujimori
  • Process for the preparation of (1r,4r)-6?-fluoro-(N,N-dimethyl- and N-methyl)-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano-[3,4,b]indol]-4-amine
    Patent number: 8779160
    Abstract: A process for the preparation of (1r,4r)-6?-fluoro-N,N-dimethyl-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano[3,4b]indol]-4-amine and (1r,4r)-6?-fluoro-N-methyl-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano[3,4b]-indol]-4-amine or physiologically acceptable acid addition salts thereof.
    Type: Grant
    Filed: December 11, 2012
    Date of Patent: July 15, 2014
    Assignee: Gruenenthal GmbH
    Inventors: Stefan Pruehs, Carsten Griebel, Wolfgang Hell
  • Asenapine maleate
    Patent number: 8779161
    Abstract: Aspects of the present application relate to a microcrystalline monoclinic form of asenapine maleate represented by structural Formula (I); processes for its preparation; and pharmaceutically acceptable dosage forms thereof.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: July 15, 2014
    Assignees: Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
    Inventors: Srinivas Katkam, Srinivas Polavarapu, Venkata Madhavi Yaddanapudi, Krishna Vinigari, Narasimha Rao Pagadala, Rajeshwar Reddy Sagyam
  • Cyanate ester compounds and cured products thereof
    Patent number: 8779162
    Abstract: There is provided a novel cyanate ester compound that can provide a cured product possessing excellent heat resistance. The cyanate ester compound is represented by general formula (1): wherein R1 represents an aromatic substituent having 6 to 10 carbon atoms or an alkyl group having 1 to 20 carbon atoms; Rx1's each independently represent a hydrogen atom, an alkyl or alkoxy group having 1 to 20 carbon atoms, or a halogen; Ry1's each independently represent a hydrogen atom, an alkyl or alkoxy group having 1 to 20 carbon atoms, or a halogen; m is an integer of 0 to 4; and n is an integer of 0 to 4.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: July 15, 2014
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Taketo Ikeno, Makoto Tsubuku, Masayuki Katagiri, Tomoo Tsujimoto
  • Synthesis of UDP-Glucose: -acylsphingosine glucosyl transferase inhibitors
    Patent number: 8779163
    Abstract: Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: July 15, 2014
    Assignee: Genzyme Corporation
    Inventors: Bradford H. Hirth, Craig Siegel
  • Phosphine-based catalysts useful for the telomerization of butadiene
    Patent number: 8779164
    Abstract: A phosphine-based catalyst composition suitable for the telomerization of butadiene to produce 1-octene includes palladium and one of a class of novel phosphine ligands characterized by two potentially functionalized phenyl rings and cyclized 5- or 6-member alkoxy groups that, together, bridge the two potentially functionalized phenyl rings. In these groups the alkoxy moiety of each is located ortho to at least one functionalizing moiety, if any, on the phenyl rings. The catalysts including this class of phosphine ligands may exhibit higher catalytic activity and selectivity, and may be used at lower temperatures, than many other phosphine ligand catalysts, reducing costs. Palladium precipitation may also be reduced.
    Type: Grant
    Filed: February 17, 2010
    Date of Patent: July 15, 2014
    Assignee: Dow Global Technologies LLC
    Inventors: Petrus Van Leeuwen, Mathieu Tschan, Zoraida Freixa, Henk Hagen
  • Fluorescent ion indicators and their applications
    Patent number: 8779165
    Abstract: Fluorescent dyes useful for preparing fluorescent metal ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators for the detection, discrimination and quantification of metal cations.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: July 15, 2014
    Assignee: AAT Bioquest, Inc.
    Inventors: Zhenjun Diwu, Jianjun He, Jinfang Liao
  • Polymers bearing pendant pentafluorophenyl ester groups, and methods of synthesis and functionalization thereof
    Patent number: 8779166
    Abstract: A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl ester group is disclosed. The cyclic carbonyl compounds can be polymerized by ring opening methods to form ROP polymers comprising repeat units comprising a side chain pentafluorophenyl ester group. Using a suitable nucleophile, the pendant pentafluorophenyl ester group can be selectively transformed into a variety of other functional groups before or after the ring opening polymerization.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: July 15, 2014
    Assignee: International Business Machines Corporation
    Inventors: James Lupton Hedrick, Alshakim Nelson, Daniel Paul Sanders
  • Method for preparing a statin compound by lactonization
    Patent number: 8779167
    Abstract: A method for preparing a statin compound by lactonization is disclosed, which comprises the following step: lactonizing a compound of formula II into the compound of formula I in the presence of a strong acid catalyst and a dehydrant in a first solvent, wherein Z represents H, ammonium, or a metal cations; R1 is H or C1-C6 alkyl, preferably H or CH3, R2 is CH3, OH, CH2OH, CH2OC(O)R3, CH2OR3, or COOR4, preferably CH3 or OH, R3 and R4 are independently selected from the group consisting of H and C1-C6 alkyl.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: July 15, 2014
    Assignees: Peking University Founder Group Co., Ltd., Southwest Synthetic Pharmaceutical Corp., Ltd., PKU International Healthcare Group Co., Ltd.
    Inventors: Deyin Ma, Qingkai He, Yunhui Zhang
  • Lactone compounds and materials made therefrom
    Patent number: 8779168
    Abstract: The present invention relates to lactone compounds represented by the following Formulas I and II, and methods of making such lactone compounds. The present invention also relates to methods of making other materials from such lactone compounds, such as fused ring indenol compounds (e.g., indeno-fused naphthols), and fused ring indenopyran compounds (e.g., indeno-fused naphthopyrans).
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: July 15, 2014
    Assignee: Transitions Optical, Inc.
    Inventors: Meng He, Darrin R. Dabideen, Ruisong Xu, Anil Kumar
  • Process for the preparation of 2 substituted tetrahydropyranols
    Patent number: 8779169
    Abstract: The present invention relates to a process for the preparation of 2-substituted 4-hydroxy-4-methyltetrahydropyrans by reacting 3-methylbut-3-en-1-ol(isoprenol) with the corresponding alkenealdehydes in the presence of a strongly acidic ion exchanger with subsequent hydrogenation. Specifically, the present invention relates to a corresponding process for the preparation of 2-isobutyl-4-hydroxy-4-methyltetrahydropyran by reacting isoprenol with prenal, with subsequent hydrogenation.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: July 15, 2014
    Assignee: BASF SE
    Inventors: Gabriele Gralla, Ralf Pelzer
  • Method of producing beraprost
    Patent number: 8779170
    Abstract: An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: July 15, 2014
    Assignee: Lung Biotechnology Inc.
    Inventors: Vijay Sharma, Hitesh Batra, Sudersan Tuladhar
  • Hydroxamates as therapeutic agents
    Patent number: 8779171
    Abstract: The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed.
    Type: Grant
    Filed: January 17, 2013
    Date of Patent: July 15, 2014
    Assignee: Pharmacyclics, Inc.
    Inventors: Erik J. Verner, Martin Sendzik, Chitra Baskaran, Joseph J. Buggy, James Robinson
  • Corn stillage oil derivatives
    Patent number: 8779172
    Abstract: Corn stillage oil derivatives having values for Gardner color of 10 or less and methods for making the corn stillage oil derivatives are disclosed. In one aspect, the corn stillage oil derivative comprises a heat bleached corn stillage oil. Preferably, the heat bleached corn stillage oil has a value for Gardner color of from 4 to 8. In another aspect, the corn stillage oil derivative comprises a blown corn stillage oil. Preferably, the blown corn stillage oil has a value for Gardner color of from 5 to 8.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: July 15, 2014
    Assignee: Cargill, Incorporated
    Inventor: Frank P. Lochel
  • Method of preparing silica composite particles
    Patent number: 8779173
    Abstract: Provided is a method of preparing silica composite particles, including treating silica particles, wherein the treating is for treating the silica particles with a metal compound in which a metal atom binds to an organic group via an oxygen atom, in supercritical carbon dioxide, and the metal atom is selected from a group consisting of Ti, Al, Zr, V, and Mg.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: July 15, 2014
    Assignee: Fuji Xerox Co., Ltd.
    Inventors: Hiroyoshi Okuno, Takeshi Iwanaga, Yoshifumi Iida, Chika Hama, Yasunobu Kashima, Shunsuke Nozaki
  • Titanium complex, processes for producing the same, titanium-containing thin film, and process for producing the same
    Patent number: 8779174
    Abstract: A subject for the invention is to provide novel titanium complexes which have a high vapor pressure and high thermal stability and serve as an excellent material for producing a titanium-containing thin film by a technique such as the CVD method or ALD method and to further provide processes for producing these complexes, titanium-containing thin films produced from the complexes, and a process for producing the thin films. The invention relates to producing a titanium complex represented by general formula (1): (wherein R1 and R4 each independently represent an alkyl group having 1-16 carbon atoms; R2 and R3 each independently represent a hydrogen atom or an alkyl group having 1-3 carbon atoms; and R5 represents an alkyl group which has 1-16 carbon atoms and may have been substituted with one or more fluorine atoms) and to producing a titanium-containing thin film using the complex.
    Type: Grant
    Filed: June 12, 2009
    Date of Patent: July 15, 2014
    Assignees: Tosoh Corporation, Sagami Chemical Research Institute
    Inventors: Ken-ichi Tada, Toshiki Yamamoto, Hirokazu Chiba, Kohei Iwanaga, Atsushi Maniwa, Tadahiro Yotsuya, Noriaki Oshima
  • Coordination complexes, pharmaceutical solutions comprising coordination complexes, and methods of treating patients
    Patent number: 8779175
    Abstract: A coordination complex having a physiologically acceptable pKa includes a metal and a biologically active agent. The pKa of the coordination complex is less than the pKa of the biologically active agent. A pharmaceutical solution for treating a patient includes a coordination complex and water, wherein the coordination complex is at least partially soluble in the water at physiological pH and in a therapeutically efficacious concentration. A method for treating a patient includes administering a pharmaceutical solution including a coordination complex and water to a patient in need of a biologically active agent.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: July 15, 2014
    Assignee: Synthonics, Inc.
    Inventors: Thomas Piccariello, John D. Price, Robert A. Oberlender, Michaela E. Mulhare, Mary C. Spencer, Scott B. Palmer
  • Metal complexes
    Patent number: 8779176
    Abstract: The present invention relates, inter alia, to metal complexes having improved solubility, process for the preparation of the metal complexes, devices comprising these metal complexes, and the use of the metal complexes.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: July 15, 2014
    Assignee: Merck Patent GmbH
    Inventors: Rémi Manouk Anémian, Bernd Schröder, Amir Hossain Parham, Claire De Nonancourt
  • Method for bottom-up graphene sheet preparation and bandgap engineering
    Patent number: 8779177
    Abstract: A combination of a substrate selected from silicon, silicon carbide or a metal and a graphene precursor having the following properties: (a) an aromatic structure that forms the basis of the graphene structure, said aromatic structure being selected from the group consisting of: benzene, naphthalene, pyrene, anthracene, chrysene, coronene, and phenanthrene, or a cyclic or acyclic structures which can be converted to aromatic structures and (b) functional groups that can react with each other to form additional aromatic structures.
    Type: Grant
    Filed: December 2, 2010
    Date of Patent: July 15, 2014
    Assignee: HRL Laboratories, LLC
    Inventors: Chaoyin Zhou, Tina T. Salguero
  • Hydrolysis-resistant silicone compounds
    Patent number: 8779178
    Abstract: In one aspect, the invention relates to hydrolysis-resistant silicone compounds. In particular, disclosed are sterically hindered hydrolysis-resistant silicone compounds and improved purity hydrolysis-resistant silicone compounds. Also disclosed are processes for making hydrolysis-resistant silicone compounds; the products of the disclosed processes; compositions and polymers comprising the disclosed compounds and products of the disclosed processes; and ophthalmic lenses, for example contact lenses, intraocular lenses, artificial cornea, and spectacle lenses, comprising the disclosed compositions, disclosed polymers, disclosed compounds, and products of the disclosed processes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: January 21, 2013
    Date of Patent: July 15, 2014
    Assignees: Johnson & Johnson Vision Care, Inc., Toray Industries, Inc.
    Inventors: Kazuhiko Fujisawa, Masataka Nakamura, Yokota Yokota, Douglas G. Vanderlaan
  • Synthesis of silyl acetylenes
    Patent number: 8779179
    Abstract: The present disclosure provides a method of preparing silylethynyl compounds in which two of the hydrocarbyl groups bonded to the silicon exclusive of the ethynyl group, are the same and one is different, that may be used in preparing novel silylethynyl functionalized acene semiconductor chromophores.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: July 15, 2014
    Assignee: 3M Innovative Properties Company
    Inventors: Robert S. Clough, John E. Anthony, Marcia M. Payne
  • Process for removing an alkanol impurity from an organic carbonate stream
    Patent number: 8779180
    Abstract: The invention relates to a process for removing an alkanol impurity from a stream containing an organic carbonate and the alkanol impurity, comprising contacting the stream with a catalyst to effect reaction of the alkanol impurity with the organic carbonate.
    Type: Grant
    Filed: October 16, 2009
    Date of Patent: July 15, 2014
    Assignee: Shell Oil Company
    Inventors: Evert Van Der Heide, Garo Garbis Vaporciyan, Cornelis Leonardus Maria Vrouwenvelder
  • Process for preparing isocyanates
    Patent number: 8779181
    Abstract: The invention relates to a process for preparing isocyanates by reacting the corresponding amines with phosgene in the gas phase, if appropriate in the presence of an inert medium, in which the amine and the phosgene are first mixed and converted to the isocyanate in a reactor, and in which a reaction gas which comprises isocyanate and hydrogen chloride and leaves the reactor is cooled in a quench space of a quench by adding a quench medium. The quench medium on addition to the quench space has a temperature above the condensation temperature or the desublimation temperature of the reaction gas.
    Type: Grant
    Filed: October 8, 2009
    Date of Patent: July 15, 2014
    Assignee: BASF SE
    Inventors: Torsten Mattke, Carsten Knoesche
  • Process for the simultaneous production of different mixtures of diisocyanate isomers of the diphenylmethane series
    Patent number: 8779182
    Abstract: Process for the simultaneous and continuous production of two different mixtures of predominantly 4,4?-MDI and 2,4?-MDI in a single-step suspension melt crystallisation process whereby a mixed diisocyanate feed stream [MIx] is used to produce simultaneously two mixed diisocyanate streams [MIy] and [MIz] wherein x=80 to 92, y=97 to 99 and z=60 to 80 preferably x=82 to 88, y=97.2 to 98.5 and z=63 to 70 where x, y and z are percentages by weight of the 4,4?-MDI isomer contained in the diisocyanate isomer mixture.
    Type: Grant
    Filed: October 1, 2009
    Date of Patent: July 15, 2014
    Assignee: Huntsman International LLC
    Inventors: Johannes Lodewijk Koole, Adolf Daan Zijl, Robert Henry Carr
  • Acid generating agent for chemically amplified resist compositions
    Patent number: 8779183
    Abstract: An acid generating agent used for chemically amplified resist compositions is provided, which agent is represented by the following formula (1): wherein X represents a monocyclic or polycyclic hydrocarbon group having 3 to 30 carbon atoms, and having at least one hydrogen atom on the ring substituted by an alkyl or alkoxy group which may be unsubstituted or substituted with a group selected from an ether group, an ester group, a carbonyl group, an acetal group, an epoxy group, a nitrile group and an aldehyde group, or by a perfluoroalkyl group, a hydroxyalkyl group, or a cyano group; R6 is an alkyl group, an alkoxy group, or a heteroatom selected from the group consisting of N, S and F; m is an integer from 0 to 2; and A+ is an organic counterion.
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: July 15, 2014
    Assignee: Korea Kumho Petrochemical Co., Ltd.
    Inventors: Jung-Hoon Oh, Dong-Cheol Seo, Hyun-Sang Joo, Chang-Soo Lee
  • Manufacturing method for sulfonic acid group-containing ether compound
    Patent number: 8779184
    Abstract: The present invention provides a method for efficiently producing a sulfonic acid group-containing ether compound having a high purity and a good polymerizability while preventing production of a byproduct, and provides a sulfonic acid group-containing ether compound containing fewer impurities and having a good radical (co)polymerizability. The present invention provides a method of producing a sulfonic acid group-containing ether compound by reacting a sulfurous acid compound with a compound represented by the formula (1): wherein R1 represents a single bond, a CH2 group, or a CH2CH2 group, and R2 represents H, or a CH3 group, the method comprising the steps of: adjusting pH of a reaction system to 5.5 or greater with use of an alkaline substance; and adding the compound represented by the formula (1) to a reaction vessel containing the sulfurous acid compound.
    Type: Grant
    Filed: September 14, 2009
    Date of Patent: July 15, 2014
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Masato Nakano, Akihiko Kanzaki, Takahiro Tsumori
  • Process and apparatus for manufacturing pure forms of aromatic carboxylic acids
    Patent number: 8779185
    Abstract: A process and apparatus for manufacture of aromatic carboxylic acids comprises a liquid phase oxidation of aromatic hydrocarbon feed materials and treatment of a high pressure off-gas from the liquid phase oxidation to separate water and reaction solvent and purification of impure aromatic carboxylic acid products wherein a purification liquid includes water from off-gas treatment.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: July 15, 2014
    Assignee: BP Corporation North America Inc.
    Inventor: Thomas M. Bartos
  • Process for the synthesis of fluorinated ethers of aromatic acids
    Patent number: 8779186
    Abstract: New fluorinated ethers of aromatic acids and diesters are disclosed. These compositions can be applied to, e.g., fibers, yarns, carpets, garments, films, molded parts, paper and cardboard, stone, and tile to impart soil, water and oil resistance. By incorporating the fluorinated ethers of aromatic acids, or diesters thereof, into polymer backbones, more lasting soil, water and oil resistance, as well as improved flame retardance, can be achieved.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: July 15, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: Neville Everton Drysdale, Kenneth Gene Moloy, Joachim C. Ritter, Joel M. Pollino, Surbhi Mahajan Du
  • Soft-gelatin capsule formulation
    Patent number: 8779187
    Abstract: The present invention discloses a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which comprises: a soft gelatin capsule shell comprising gelatin and sugar alcohol as a plasticizer, and a mixture comprising a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto-prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: July 15, 2014
    Assignees: Sumcampo AG, R-Tech Ueno, Ltd.
    Inventors: Yukiko Hashitera, Ryu Hirata, Yasuhiro Harada, Ryuji Ueno
  • Process for the production of L-carnitine tartrate
    Patent number: 8779188
    Abstract: The invention relates to a process for the production of L-carnitine tartrate, wherein the L-carnitine tartrate is precipitated from a reaction mixture comprising L-carnitine and tartaric acid dissolved in ethanol, the ethanol having a water content of less than 5% (w/w).
    Type: Grant
    Filed: September 6, 2011
    Date of Patent: July 15, 2014
    Assignee: Lonza Ltd.
    Inventors: Thomas Buechner, Uwe Zacher
  • High protein supplement
    Patent number: 8779189
    Abstract: The present disclosure relates to high protein dietary supplements for treating various symptoms and diseases associated with protein deficiency including weight gain, obesity, catabolic diseases, fibromyalgia, anxiety reactions, posttraumatic stress and chronic fatigue syndrome. Embodiments of dietary supplements comprise combinations of proteins, essential and semi-essential amino acids including L-Lysine, L-Arginine, and/or L-Histidine.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: July 15, 2014
    Inventor: George Scheele