Patents Issued in July 29, 2014
-
Patent number: 8790839Abstract: A fuel cell system for use with an endothermic fuel generator including a fuel cell stack having a primary fuel cell stack having a first thermal mass and a secondary fuel cell stack having a second thermal mass smaller than the first, the fuel cell system further including a first thermal coupling mechanism configured to thermally couple waste heat from the secondary fuel cell stack to the primary fuel cell stack, and a second thermal coupling mechanism configured to thermally couple waste heat from the fuel cell stack to the endothermic fuel generator.Type: GrantFiled: August 2, 2012Date of Patent: July 29, 2014Assignee: Ardica Technologies, Inc.Inventors: Daniel Braithwaite, Tibor Fabian, Friedrich B. Prince
-
Patent number: 8790840Abstract: Thermal and hydration management systems and methods for fuel cell systems, including control of electrolytic membrane hydration levels. In some embodiments, the thermal properties of the fuel cell are controlled based on a variable associated with the oxidant supply stream and/or a variable associated with the fuel cell energy output. In some embodiments, the temperature of the fuel cell is controlled based on the temperature of the oxidant supply stream. In some embodiments, the temperature range across the fuel cell stack is controlled based on the flow rate of the oxidant stream and the electrical output generated by the fuel cell stack. In some embodiments, the humidity within the fuel cell stack is controlled. In some embodiments, the liquid water content of the cathode exhaust stream is controlled.Type: GrantFiled: March 10, 2010Date of Patent: July 29, 2014Assignee: DCNS SAInventors: Sudha Rani LaVen, Luc Rouveyre
-
Patent number: 8790841Abstract: A metal alloy catalyst for the oxygen reduction reaction in fuel cells is disclosed. The catalyst contains the metals Pd, M1 and M2. M1 and M2 are different metals selected from Co, Fe, Au, Cr and W, excluding the combination PdCoAu.Type: GrantFiled: November 8, 2012Date of Patent: July 29, 2014Assignee: Ilika Technologies Ltd.Inventors: Karen Marie Brace, Brian Elliot Hayden, Christopher Edward Lee, Thierry Le Gall
-
Patent number: 8790842Abstract: Fuel cell systems and methods having reduced volumetric requirements are described. The systems include, among other things, an enclosed region formed by the bonding of a fuel cell layer with a fluid manifold. The enclosed region transforms into a fluid plenum when, for example, a fluid exiting a manifold outlet pressurizes the enclosed region causing one or more portions of the fuel cell layer and/or the fluid manifold to deform away from each other.Type: GrantFiled: September 25, 2008Date of Patent: July 29, 2014Assignee: Societe BICInventors: Jeremy Schrooten, Paul Sobejko, Gerard F McLean
-
Patent number: 8790843Abstract: A fuel cell stack includes a plurality of membrane electrode assemblies (MEAs) and a stamped metal separator. The metal separator is positioned between the membrane electrode assemblies. The separator includes at least one channel on both surfaces of the separator formed by a stamping process. The separator comprises a plurality of holes, each of which form a manifold communicating with each the channels.Type: GrantFiled: January 24, 2008Date of Patent: July 29, 2014Assignee: Samsung SDI Co., LtdInventors: Young-Seung Na, Jun-Won Suh, In-Seob Song, Keun-Yong Lee, Sung-Won Jeong, Chan-Gyun Shin
-
Patent number: 8790844Abstract: A fuel cell stack with a plurality of membrane electrode assemblies (MEAs) and a plurality of bipolar plates, wherein at least one surface of a first bipolar plate runs in undulating fashion, meandering fashion or zig-zag-shaped fashion and extreme points of the surface of the bipolar plate make contact with a first surface of a MEA at contact points. At least some of the contact points are associated with mating contact points on a second surface of the MEA, which surface is opposite the first surface of the MEA, with a surface of a second bipolar plate making contact with said mating contact points, and that the contact points and the associated mating contact points are positioned one above the other in the stacking direction. A method for producing a fuel cell stack is provided. A bipolar plate for a fuel cell stack is also provided.Type: GrantFiled: September 29, 2009Date of Patent: July 29, 2014Assignee: Staxera GmbHInventor: Andreas Reinert
-
Patent number: 8790845Abstract: One embodiment includes a substrate having a plurality of molecular chains, each chain comprising a hydrophilic group, a hydrophobic segment, and a reversible crosslinker.Type: GrantFiled: June 4, 2010Date of Patent: July 29, 2014Assignee: GM Global Technology Operations LLCInventor: Tao Xie
-
Patent number: 8790846Abstract: An object of the present invention is to provide a gas diffusion layer having gas flow passages formed at its one main surface, which is capable of achieving a further improvement in power generation performance. The fuel cell-use gas diffusion layer (14A, 14C) of the present invention has a double-layer structure made up of a first diffusion layer (15A, 15C) having gas flow passages (21A, 21C) at its one main surface, and a second diffusion layer (16A, 16C) disposed on the other main surface of the first diffusion layer. The first diffusion layer and the second diffusion layer are each structured with a porous member mainly comprised of conductive particles and a polymer resin, and the first diffusion layer is structured to be lower in porosity than the second diffusion layer.Type: GrantFiled: July 2, 2010Date of Patent: July 29, 2014Assignee: Panasonic CorporationInventors: Masaki Yamauchi, Yoichiro Tsuji
-
Patent number: 8790847Abstract: A method of producing a reversible solid oxide cell. The method includes the steps of tape casting an anode support layer on a support (1); tape casting an anode layer on a support (2); tape casting an electrolyte layer on a support (3); and either laminating said anode layer on top of said anode support layer; removing said support (2) from said anode layer; laminating said electrolyte layer on top of said anode layer; and sintering the multilayer structure; or laminating said anode layer on top of said electrolyte layer; removing said support (2) from said anode layer; laminating said anode support layer on top of said anode layer; and sintering the multilayer structure.Type: GrantFiled: November 21, 2007Date of Patent: July 29, 2014Assignee: Technical University of DenmarkInventors: Peter Halvor Larsen, Karen Brodersen
-
Patent number: 8790848Abstract: In fuel cell separator, the periphery of manifold through which fuel gas, reaction water, etc., pass and the seal line being a site of bonding with an adjacent separator are provided with a resin layer. Within the surface of the separator, the resin application site on which the resin layer is formed undergoes subbing treatment in advance to thereby increase the capability of bonding with the resin. When the resin layer consists of a resin having an NH group, as the subbing treatment, hydroxide deposition treatment is carried out on the surface of the separator.Type: GrantFiled: February 22, 2007Date of Patent: July 29, 2014Assignee: Toyota Jidosha Kabushiki KaishaInventors: Yusuke Watanabe, Kazutaka Iizuka
-
Patent number: 8790849Abstract: A manufacturing method for an electrode catalyst layer includes: containing a conductive carrier on which a catalyst is supported, a substrate, an electrolyte resin and a supercritical fluid inside a closed container (S102 to S106); and cooling the substrate to form an electrode catalyst layer, having the conductive carrier on which the catalyst is supported and the electrolyte resin, on the substrate (S 108).Type: GrantFiled: April 8, 2010Date of Patent: July 29, 2014Assignee: Toyota Jidosha Kabushiki KaishaInventors: Yuichiro Hama, Takayoshi Doi
-
Patent number: 8790850Abstract: A current collection apparatus and its method of processing for a solid oxide fuel cell, which mainly includes using screen printing process to print conductive adhesive onto the surface of the electrode of solid oxide fuel cell (SOFC), forming a current collection layer with drying process, using an appropriate amount of conductive adhesive to paste a conductive wire onto the current collection layer, forming an adhesion layer through drying, fixing the conductive wire on the electrode surface with an appropriate amount of ceramic adhesive, and forming a fixing layer after baking. A good connection is hence made between metal conductive wire and electrode through current collection layer, not only the interface impedance between electrode and current collection layer can be reduced effectively, but also the output power density of the SOFC unit cell can be enhanced, and stable as well as long term power output can be provided.Type: GrantFiled: March 1, 2012Date of Patent: July 29, 2014Assignee: Institute of Nuclear Energy ResearchInventors: Jen-Chen Chang, Maw-Chwain Lee, Rung-Je Yang, Tai-Nan Lin, Yang-Chuang Chang, Wei-Xin Kao, Lin-Song Lee
-
Patent number: 8790851Abstract: A photo mask for exposing according to an embodiment includes a mark pattern arranged in a mark region that is different from an effective region to form a semiconductor device; and a regular pattern arranged in the mark region and around the mark pattern and smaller than the mark pattern in size and pitch.Type: GrantFiled: August 8, 2012Date of Patent: July 29, 2014Assignee: Kabushiki Kaisha ToshibaInventors: Yosuke Okamoto, Kazutaka Ishigo, Taketo Kuriyama
-
Patent number: 8790852Abstract: The present invention provides a colored composition for a light-shielding film including at least one selected from titanium atom-containing black titanium pigments and at least one organic pigment selected from the group consisting of a red organic pigment, a yellow organic pigment, a violet organic pigment, and an orange color organic pigment, which has a maximum value of the transmittance of light having a wavelength of 400 to 700 nm of 1.5% or less when a film is formed such that the light transmittance at a wavelength of 650 nm is 0.2%, has a wavelength showing the maximum transmittance at 400 to 550 nm, and has a light transmittance at a wavelength of 400 nm of 0.1% or more.Type: GrantFiled: July 7, 2010Date of Patent: July 29, 2014Assignee: FUJIFILM CorporationInventor: Tatsuya Tanaka
-
Patent number: 8790853Abstract: The present disclosure is directed to charge generating compositions and methods of making the charge generating compositions. The composition may comprise one or more polymers comprising styrene units and allyl alcohol units, and one or more photoconductive particles. Electrophotographic devices employing the compositions, including methods of making the devices, are also disclosed.Type: GrantFiled: March 1, 2006Date of Patent: July 29, 2014Assignee: Xerox CorporationInventors: Jin Wu, John J. Wilbert, Marc J. Livecchi, Liang-bih Lin
-
Patent number: 8790854Abstract: An electrophotographic photoreceptor includes a substrate and a photosensitive layer, wherein the electrophotographic photoreceptor has a surface layer containing fluorine resin particles, and the fluorine resin particles exposed on a surface satisfy the following Expression (1): 0.5?(A)/(B)?10??Expression (1) wherein, (A) represents a number of aggregated particles in which 5 to 20 fluorine resin particles are connected and aggregated, and (B) represents a total number of fluorine resin particles that are isolated without being aggregated and aggregated particles in which 2 to 4 fluorine resin particles are connected and aggregated.Type: GrantFiled: September 28, 2012Date of Patent: July 29, 2014Assignee: Fuji Xerox Co., Ltd.Inventor: Yukimi Kawabata
-
Patent number: 8790855Abstract: The present invention provides a charge control agent containing, as an active substance(s), one or two or more thiazolidinedione derivatives represented by the following formula (1), where R1 represents a hydrogen atom, etc.; R2 represents a hydrogen atom, a linear or branched alkyl group having 1 to 8 carbon atoms which may have a substituent, etc.; R3 to R7, which may be identical to or different from each other, represent a hydrogen atom, a chlorine atom, a linear or branched alkyl group having 1 to 8 carbon atoms which may have a substituent, etc., and may be joined to each other to form a ring; and V, W, X, Y and Z represent a carbon atom or a nitrogen atom, and 0 to 3 of any of V, W, X, Y and Z are nitrogen atoms which do not have the substituents of R3 to R7.Type: GrantFiled: September 1, 2011Date of Patent: July 29, 2014Assignee: Hodogaya Chemical Co., LtdInventors: Ikuo Kimura, Motonori Tsuji, Masami Ito, Masaya Tojo, Kanae Hiraishi
-
Patent number: 8790856Abstract: The present disclosure describes toner compositions containing an additive package including one or more additives that exhibit low dielectric loss, which toners exhibit improved tribo charging, 2nd transfer efficiency and IQ without affecting color.Type: GrantFiled: November 9, 2011Date of Patent: July 29, 2014Assignee: Xerox CorporationInventors: Suxia Yang, Richard P N Veregin, Magid Kamel, Cuong Vong, Kimberly Nosella, Eric Rotberg
-
Patent number: 8790857Abstract: Disclosed is a toner obtained by coating surfaces of core particles including at least a binder resin having a carboxyl group and a coloring agent with successive coatings of a water-soluble crosslinking agent capable of crosslinking with a carboxyl group and a water-soluble polymer having a carboxyl group, which have been successively applied on the core particles and crosslinked with each other. The thus-formed toner is provided with a good harmony of favorable fixability represented by a low lowest fixable temperature and favorable storage stability represented by little aggregation after standing at 50° C. for 8 hours.Type: GrantFiled: June 29, 2012Date of Patent: July 29, 2014Assignee: Toshiba Tec Kabushiki KaishaInventors: Tsuyoshi Itou, Motonari Udo, Kazuhisa Takeda, Takayasu Aoki, Masahiro Ikuta, Takafumi Hara
-
Patent number: 8790858Abstract: An electrostatic charge image developing carrier has magnetic particles and a coating resin layer that coats surfaces of the magnetic particles and contains a hindered amine compound.Type: GrantFiled: August 10, 2012Date of Patent: July 29, 2014Assignee: Fuji Xerox Co., Ltd.Inventors: Toshiaki Hasegawa, Mona Tasaki, Fusako Kiyono
-
Patent number: 8790859Abstract: The present invention relates to a photoresist composition for digital exposure and a method of fabricating a thin film transistor substrate. The photoresist composition for digital exposure includes a binder resin including a novolak resin and a compound represented by the chemical formula (1), a photosensitizer including a diazide-based compound, and a solvent: wherein R1-R9 each include a hydrogen atom, an alkyl group, or a benzyl group, a is an integer from 0 to 10, b is an integer from 0 to 100, and c is an integer from 0 to 10.Type: GrantFiled: November 18, 2009Date of Patent: July 29, 2014Assignee: Samsung Display Co., Ltd.Inventors: Sang-Hyun Yun, Woo-Seok Jeon, Jung-In Park, Hi-Kuk Lee, Byung-Uk Kim, Dong-Min Kim, Seung-Ki Kim, Ja-Hun Byeon
-
Patent number: 8790860Abstract: An actinic ray-sensitive or radiation-sensitive resin composition capable of forming a hole pattern which has an ultrafine pore diameter (for example, 60 nm or less) and has an excellent cross-sectional shape with excellent local pattern dimensional uniformity; and a resist film, a pattern forming method, a method for preparing an electronic device, and an electronic device, each using the same, are provided.Type: GrantFiled: September 11, 2012Date of Patent: July 29, 2014Assignee: FUJIFILM CorporationInventors: Kosuke Koshijima, Hidenori Takahashi, Shuhei Yamaguchi, Kei Yamamoto
-
Patent number: 8790861Abstract: A monomer has the Formula I: wherein R1, R2, and R3 are each independently a C1-30 monovalent organic group, and R1, R2, and R3 are each independently unsubstituted or include a halogen, nitrile, ether, ester, ketone, alcohol, or a combination comprising at least one of the foregoing functional groups; R4 includes H, F, C1-4 alkyl, or C1-4 fluoroalkyl; A is a single bond or a divalent linker group, wherein A is unsubstituted or substituted to include a halogen, nitrile, ether, ester, ketone, alcohol, or a combination comprising at least one of the foregoing functional groups; m and n are each independently an integer of 1 to 8; and x is 0 to 2n+2, and y is 0 to 2m+2.Type: GrantFiled: December 21, 2012Date of Patent: July 29, 2014Assignee: Rohm and Haas Electronic Materials LLCInventors: Cong Liu, Mingqi Li, Cheng-Bai Xu
-
Patent number: 8790862Abstract: The invention provides a photosensitive element and a method for preparing a printing form from the element. The photosensitive element includes a layer of a photosensitive composition containing a binder, a monomer, and a Norrish type II photoinitiator, wherein the photosensitive layer has a transmittance to actinic radiation of less than 20% and contains reinforcing particles of graphene and/or carbon nanotubes.Type: GrantFiled: January 16, 2013Date of Patent: July 29, 2014Assignee: E I du Pont de Nemours and CompanyInventor: Adrian Lungu
-
Patent number: 8790863Abstract: In a method for imaging a solid state substrate, a vapor is condensed to an amorphous solid water condensate layer on a surface of a solid state substrate. Then an image of at least a portion of the substrate surface is produced by scanning an electron beam along the substrate surface through the water condensate layer. The water condensate layer integrity is maintained during electron beam scanning to prevent electron-beam contamination from reaching the substrate during electron beam scanning. Then one or more regions of the layer can be locally removed by directing an electron beam at the regions. A material layer can be deposited on top of the water condensate layer and any substrate surface exposed at the one or more regions, and the water condensate layer and regions of the material layer on top of the layer can be removed, leaving a patterned material layer on the substrate.Type: GrantFiled: October 26, 2011Date of Patent: July 29, 2014Assignee: President and Fellows of Harvard CollegeInventors: Daniel Branton, Anpan Han, Jene A. Golovchenko
-
Patent number: 8790864Abstract: A method of tailoring the shape of a plurality of relief printing dots created in a photosensitive printing blank during a platemaking process is provided. The photocurable layer is exposed to actinic radiation using an array of UV LED light assemblies and the use of the array of UV LED light assemblies produces relief printing dots having at least one geometric characteristic selected from the group consisting of a desired planarity of a top surface of the relief printing dots, a desired shoulder angle of the relief printing dots and a desired edge sharpness of the relief printing dots.Type: GrantFiled: August 27, 2012Date of Patent: July 29, 2014Inventor: Kyle P. Baldwin
-
Patent number: 8790865Abstract: The present disclosure relates to a method of fabricating a capacitive touch pane where a plurality of groups of first conductive patterns are formed along a first direction, a plurality of groups of second conductive patterns are formed along a second direction, and a plurality of connection components are formed on a substrate. Each first conductive pattern is electrically connected to another adjacent first conductive pattern in the same group by each connection component and each group of the second conductive patterns is interlaced with and insulated from each group of the first conductive patterns. Next, a plurality of curved insulation mounds are formed to cover the first connection components. Then, a plurality of bridge components are formed to electrically connect each second conductive pattern with another adjacent second conductive pattern in the same group.Type: GrantFiled: September 11, 2013Date of Patent: July 29, 2014Assignees: Innocom Technology (Shenzhen) Co., Ltd., Innolux CorporationInventors: Chao-Sung Li, Lien-Hsin Lee, Kai Meng
-
Patent number: 8790866Abstract: A negative pattern is formed by coating a resist composition comprising a methylol-substituted urea, amide or urethane compound, a polymer comprising recurring units having an acid labile group-substituted hydroxyl group, and an acid generator onto a substrate, prebaking, exposing to high-energy radiation, and developing in an organic solvent developer such that the unexposed region of resist film is dissolved away and the exposed region of resist film is not dissolved. In image formation via positive/negative reversal by organic solvent development, the resist film is characterized by a high dissolution contrast between the unexposed and exposed regions.Type: GrantFiled: August 15, 2012Date of Patent: July 29, 2014Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Jun Hatakeyama, Kazuhiro Katayama, Tomohiro Kobayashi
-
Patent number: 8790867Abstract: Provided are methods of forming photolithographic patterns by negative tone development. The methods employ a photoresist composition that includes a polymer having a unit of the following general formula (I): wherein: R1 represents hydrogen or a C1 to C3 alkyl group; a represents an integer from 1 to 3; and b represents 0 or 1. The methods find particular applicability in the manufacture of semiconductor devices.Type: GrantFiled: November 3, 2012Date of Patent: July 29, 2014Assignee: Rohm and Haas Electronic Materials LLCInventors: Young Cheol Bae, Jibin Sun, Seung-Hyun Lee, Jong Keun Park, Cecily Andes
-
Patent number: 8790868Abstract: A method of forming a resist pattern, the method including: forming a resist film on a substrate using a resist composition containing a base component (A) that exhibits reduced solubility in an organic solvent under the action of acid, an acid generator component (B) that generates acid upon exposure and a fluorine-containing polymeric compound (F), exposing the resist film, and patterning the resist film by negative tone development using a developing solution containing the organic solvent, thereby forming a resist pattern, wherein the base component (A) contains a resin component (A1) containing a structural unit (a1) derived from an acrylate ester, the dissolution rates of (A1) and (F) in the developing solution are each at least 10 nm/s, and the absolute value of the difference in the dissolution rates of (A1) and (F) in the developing solution is not more than 80 nm/s.Type: GrantFiled: April 26, 2012Date of Patent: July 29, 2014Assignee: Tokyo Ohka Kogyo Co., Ltd.Inventors: Hiroaki Shimizu, Hideto Nito
-
Patent number: 8790869Abstract: Disclosed herein is a method of identifying a tumor biomarker. In one example, a tumor biomarker is identified by obtaining a peripheral biological fluid sample from a subject with a tumor as well as a tumor sample and an adjacent non-tumor sample from such subject. A protein expression profile is detected in the peripheral biological fluid sample, tumor sample and adjacent non-tumor sample. The protein expression profiles of the peripheral biological fluid sample, tumor sample and adjacent non-tumor sample are then compared, wherein an increase in expression of a specific protein in the tumor sample and peripheral biological fluid sample but not in the adjacent non-tumor sample indicates that the specific protein is a biomarker of the tumor. Also disclosed herein is a gene profiling signature that can be used to diagnosis a subject with renal cell carcinoma (RCC) or to identify agents with therapeutic potential to treat RCC. Thus, methods of diagnosing a subject with RCC are disclosed.Type: GrantFiled: March 20, 2009Date of Patent: July 29, 2014Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Josip Blonder, Bih-Rong Wei, Donald J. Johann, Timothy D. Veenstra
-
Patent number: 8790870Abstract: The present invention concerns a method for predicting quantitative phenotype, e.g. gag-phenotype, integrase phenotype or tropism in a patient infected by Human Immunodeficiency Virus (HIV).Type: GrantFiled: February 2, 2007Date of Patent: July 29, 2014Assignee: Virco BVBAInventors: Lieven Jozef Stuyver, Kurt Van Baelen, Ina Isabel Vandenbroucke
-
Patent number: 8790871Abstract: Disclosed herein are methods of detecting and predicting diastolic heart failure and predicting congestive heart failure comprise protease and protease inhibitor profiling.Type: GrantFiled: April 24, 2007Date of Patent: July 29, 2014Assignee: MUSC Foundation for Research DevelopmentInventors: Francis G. Spinale, Robert E. Stroud, Michael R. Zile
-
Patent number: 8790872Abstract: A method of detecting the production of an analyte by cells in a sample, which method comprises: (i) providing an antibody capable of binding to said analyte and a first agent capable of enhancing detection of said analyte, wherein said antibody and said first agent are immobilized on the same support; (ii) contacting said antibody and said agent with a sample of cells; and (iii) detecting binding of said analyte to said antibody thereby detecting the production of an analyte by cells in a sample.Type: GrantFiled: April 29, 2005Date of Patent: July 29, 2014Assignee: Mabtech ABInventors: Staffan Paulie, Sten Braesch-Andersen
-
Patent number: 8790873Abstract: Disclosed are methods and compositions for detection and amplification of nucleic acids, wherein two DNA strands hybridized to an RNA strand are ligated. In one aspect, the disclosed methods include removal of an energy source, such as ATP, upon charging a ligase to form an enzyme-AMP intermediate, and then adding substrate, which results in one complete round of RNA-templated DNA ligation. In another aspect, the ligation reaction is accomplished by use of a mixture of at least two different ligase enzymes. The disclosed methods and compositions for RNA-templated DNA ligation may be particularly useful for detection of RNA sequence variants, for example RNA splice variants, and for quantitative expression analysis.Type: GrantFiled: January 19, 2010Date of Patent: July 29, 2014Assignee: Affymetrix, Inc.Inventors: Eugeni A. Namsaraev, Xin Miao, John E. Blume
-
Patent number: 8790874Abstract: A device for investigation of a flow conduit comprising: a base; and a module formed in the base, the module comprising: a main channel for the flow conduit, the main channel having a loading inlet for loading the flow conduit; a culture chamber in the main channel for at least one of perfusion and superfusion of the flow conduit; at least two fixation lines in communication with the main channel for providing fixation of the flow conduit at at least two fixation locations along the length of the flow conduit.Type: GrantFiled: June 17, 2009Date of Patent: July 29, 2014Inventors: Axel Guenther, Steffen-Sebastian Bolz
-
Patent number: 8790875Abstract: Single nucleotide polymorphic sites of the bovine HSP genes are associated with improved fertilization rate and/or improved embryo survival rate in cattle. Nucleic acid molecules, kits, methods of genotyping and marker assisted bovine breeding methods based on these SNPs are disclosed.Type: GrantFiled: August 1, 2012Date of Patent: July 29, 2014Assignee: Wisconsin Alumni Research FoundationInventor: Hasan Khatib
-
Patent number: 8790876Abstract: An apparatus and method for performing rapid DNA sequencing, such as genomic sequencing, is provided herein. The method includes the steps of preparing a sample DNA for genomic sequencing, amplifying the prepared DNA in a representative manner, and performing multiple sequencing reaction on the amplified DNA with only one primer hybridization step.Type: GrantFiled: April 20, 2007Date of Patent: July 29, 2014Assignee: 454 Life Sciences CorporationInventors: John H. Leamon, Kenton L. Lohman, Jonathan M. Rothberg, Michael P. Weiner
-
Patent number: 8790877Abstract: The solutions provided here use DNA aptamers and quantum dots for the detection of bacteria, viruses, proteins or other targets. An example of a method described here comprises: providing a complex of DNA complementary strands, one strand being an aptamer, having one strand covalently linked to a quantum dot, and having the other strand linked to a quencher; and contacting the complex of DNA complementary strands with a microorganism or components thereof, under conditions that permit binding of the aptamer with the microorganism or components thereof.Type: GrantFiled: July 9, 2008Date of Patent: July 29, 2014Assignee: The United States of America as represented by the Secretary of the Air ForceInventors: Eric A. Holwitt, Jonathan L. Kiel, Veronica Franz Sorola
-
Patent number: 8790878Abstract: The present invention relates to compositions and methods for determining a treatment course of action. In particular, the present invention relates to compositions and methods for the prediction of a subject's response to cancer therapies and administration of appropriate treatments.Type: GrantFiled: July 7, 2011Date of Patent: July 29, 2014Assignee: The Regents of The University of MichiganInventor: Daniel Hayes
-
Patent number: 8790879Abstract: Oligonucleotides useful for determining the presence of Trichomonas vaginalis in a test sample.Type: GrantFiled: January 21, 2011Date of Patent: July 29, 2014Assignee: Gen-Probe IncorporatedInventors: Damon Kittredge Getman, Barbara Susan Weinbaum
-
Patent number: 8790880Abstract: Accurate and fast detection of the presence of Clostridium difficile (C. difficile) disease is crucial for the proper treatment of patients with C. difficile infection. Present tests detecting the presence of C. difficile disease are fast and cost effective, but are not very sensitive. Using an ELISA including Cell Wall Protein 84 (Cwp84) increases the sensitivity of the ELISA. Cwp84 may be used alone or in combination with other markers to support a diagnosis of C. difficile-associated disease.Type: GrantFiled: September 25, 2012Date of Patent: July 29, 2014Assignee: Techlab, Inc.Inventors: Manli Y. Davis, David M. Lyerly, Tracy D. Wilkins
-
Patent number: 8790881Abstract: A method for measuring immunoglobulin G-mediated complement activation, includes the following steps: a) preparing a sample A of immunoglobulin G and a sample B including natural serum, the natural serum optionally being diluted in a dilution buffer; b) mixing sample A with sample B at a ratio (amount of IgG in A in grams):(volume of natural serum in B in liters) of between and 75, at a temperature of between 2° C. and 6° C., and subsequently incubating the resulting reaction mixture at a temperature of between 35° C. and 40° C. for a period of between 30 minutes and 2 hours; c) cooling the reaction mixture obtained at the end of step b) to a temperature of between 0° C. and 4° C. in the presence of EDTA; and d) measuring the amount of C5a fragment in the cooled reaction mixture obtained in c).Type: GrantFiled: May 4, 2011Date of Patent: July 29, 2014Assignee: Laboratoire francais du Fractionnement et des BiotechnologiesInventors: Frederic Dhainaut, Gerald Perret
-
Patent number: 8790882Abstract: The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic antibody:antigen complexes, soluble antigens or soluble therapeutic antibodies may be measured and used to stage or monitor a hyperproliferative disease.Type: GrantFiled: July 3, 2013Date of Patent: July 29, 2014Assignee: Board of Regents, The University of Texas SystemInventors: Maher Albitar, Michael J. Keating, Taghi Manshouri
-
Patent number: 8790883Abstract: The present invention relates to polypeptides that inhibit the NF-?B signaling pathway and polynucleotides encoding the same. The present invention further provides methods for the modulation of and/or treatment of inflammatory responses, oncogenesis, viral infection; the regulation of cell proliferation and apoptosis; and regulation of B or T lymphocytes in antigenic stimulation, by administering the polypeptides of the present invention to a subject in need thereof. Finally, the present invention provides a method of identifying polypeptides that modulate oligomerization of NEMO.Type: GrantFiled: April 24, 2008Date of Patent: July 29, 2014Assignee: Institut PasteurInventors: Fabrice Agou, Gilles Courtois, Alain Israel, Michel Vernon, Francois Traincard, Shoji Yamaoka
-
Patent number: 8790884Abstract: A method for measuring the amount of sialic acid in immunoglobulin G and immunoglobulin G anti-ds DNA antibodies is disclosed. The method for measuring the amount of sialic acid in immunoglobulin G in the present invention uses culture fluid, blood, plasma, or serum to directly measure the amount of sialic acid in immunoglobulin G. Also, using a mouse monoclonal antibody immunoglobulin G as a standard, which is diluted from 1000 ng/ml to 15.625 ng/ml in phosphate buffered saline (PBS), produces good results. The method for measuring the amount of sialic acid in immunoglobulin G anti-ds DNA antibodies has never been done and the present invention produces good results as well.Type: GrantFiled: January 7, 2013Date of Patent: July 29, 2014Assignee: Chang Gung Medical Foundation, Linkou BranchInventor: Lieh-bang Liou
-
Patent number: 8790885Abstract: Disclosed is a technique for obtaining a coagulogen raw material which can irreversibly inactivate the activity of a coagulase while retaining the function of coagulogen in an LAL reagent, a LAL reagent contaminated by an organism-derived biologically active substance or the like, and which can be used in a reagent. An LAL reagent is heated at a predetermined temperature for a predetermined period of time to deactivate only the activity of an enzyme contained in the LAL reagent irreversibly, wherein such an activity inherent in coagulogen that coagulogen can be hydrolyzed with the activated coagulase and converted to coagulin to induce gelatinization or an agglutination reaction is retained.Type: GrantFiled: February 19, 2010Date of Patent: July 29, 2014Assignee: Kowa Company, Ltd.Inventor: Katsumi Yabusaki
-
Patent number: 8790886Abstract: Methods to assay kinase activity are provided herein. The methods employ elemental analysis, including inductively charged plasma mass spectrometry (ICP-MS). The methods allow for the convenient and accurate analysis of post-translation modifications of substrates by kinase enzymes involved in post-translational modifications.Type: GrantFiled: November 21, 2012Date of Patent: July 29, 2014Assignee: Fluidigm Canada Inc.Inventor: Olga Ornatsky
-
Patent number: 8790887Abstract: The invention relates to the field of disorders of the peripheral or central nervous system, in particular, Alzheimer's disease, and the prevention and/or treatment thereof. In particular, the invention relates to ARF6 and/or ARF6 effector proteins as new targets in Alzheimer's disease, and based thereon, screening methods for compounds that reduce amyloid beta peptide formation in mammalian cells by affecting ARF6-mediated endosomal sorting.Type: GrantFiled: December 6, 2010Date of Patent: July 29, 2014Assignees: VIB VZW, Katholieke Universiteit Leuven, K.U. Leuven R&DInventors: Wim Annaert, Ragna Sannerud, Katrijn Coen, Bart De Strooper
-
Patent number: 8790889Abstract: A method of activating a latent neural precursor cell population, comprising: (1) providing a neural cell population derived from the hippocampus; (2) introducing the neural cell population to a neurosphere-forming culture medium; and (3) activating the latent precursor cell population by treatment with a ?3 adrenergic receptor agonist.Type: GrantFiled: December 21, 2010Date of Patent: July 29, 2014Assignee: The University of QueenslandInventors: Dhanisha Jhaveri, Perry Francis Bartlett