Patents Issued in July 29, 2014
  • Patent number: 8790839
    Abstract: A fuel cell system for use with an endothermic fuel generator including a fuel cell stack having a primary fuel cell stack having a first thermal mass and a secondary fuel cell stack having a second thermal mass smaller than the first, the fuel cell system further including a first thermal coupling mechanism configured to thermally couple waste heat from the secondary fuel cell stack to the primary fuel cell stack, and a second thermal coupling mechanism configured to thermally couple waste heat from the fuel cell stack to the endothermic fuel generator.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: July 29, 2014
    Assignee: Ardica Technologies, Inc.
    Inventors: Daniel Braithwaite, Tibor Fabian, Friedrich B. Prince
  • Patent number: 8790840
    Abstract: Thermal and hydration management systems and methods for fuel cell systems, including control of electrolytic membrane hydration levels. In some embodiments, the thermal properties of the fuel cell are controlled based on a variable associated with the oxidant supply stream and/or a variable associated with the fuel cell energy output. In some embodiments, the temperature of the fuel cell is controlled based on the temperature of the oxidant supply stream. In some embodiments, the temperature range across the fuel cell stack is controlled based on the flow rate of the oxidant stream and the electrical output generated by the fuel cell stack. In some embodiments, the humidity within the fuel cell stack is controlled. In some embodiments, the liquid water content of the cathode exhaust stream is controlled.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: July 29, 2014
    Assignee: DCNS SA
    Inventors: Sudha Rani LaVen, Luc Rouveyre
  • Patent number: 8790841
    Abstract: A metal alloy catalyst for the oxygen reduction reaction in fuel cells is disclosed. The catalyst contains the metals Pd, M1 and M2. M1 and M2 are different metals selected from Co, Fe, Au, Cr and W, excluding the combination PdCoAu.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: July 29, 2014
    Assignee: Ilika Technologies Ltd.
    Inventors: Karen Marie Brace, Brian Elliot Hayden, Christopher Edward Lee, Thierry Le Gall
  • Patent number: 8790842
    Abstract: Fuel cell systems and methods having reduced volumetric requirements are described. The systems include, among other things, an enclosed region formed by the bonding of a fuel cell layer with a fluid manifold. The enclosed region transforms into a fluid plenum when, for example, a fluid exiting a manifold outlet pressurizes the enclosed region causing one or more portions of the fuel cell layer and/or the fluid manifold to deform away from each other.
    Type: Grant
    Filed: September 25, 2008
    Date of Patent: July 29, 2014
    Assignee: Societe BIC
    Inventors: Jeremy Schrooten, Paul Sobejko, Gerard F McLean
  • Patent number: 8790843
    Abstract: A fuel cell stack includes a plurality of membrane electrode assemblies (MEAs) and a stamped metal separator. The metal separator is positioned between the membrane electrode assemblies. The separator includes at least one channel on both surfaces of the separator formed by a stamping process. The separator comprises a plurality of holes, each of which form a manifold communicating with each the channels.
    Type: Grant
    Filed: January 24, 2008
    Date of Patent: July 29, 2014
    Assignee: Samsung SDI Co., Ltd
    Inventors: Young-Seung Na, Jun-Won Suh, In-Seob Song, Keun-Yong Lee, Sung-Won Jeong, Chan-Gyun Shin
  • Patent number: 8790844
    Abstract: A fuel cell stack with a plurality of membrane electrode assemblies (MEAs) and a plurality of bipolar plates, wherein at least one surface of a first bipolar plate runs in undulating fashion, meandering fashion or zig-zag-shaped fashion and extreme points of the surface of the bipolar plate make contact with a first surface of a MEA at contact points. At least some of the contact points are associated with mating contact points on a second surface of the MEA, which surface is opposite the first surface of the MEA, with a surface of a second bipolar plate making contact with said mating contact points, and that the contact points and the associated mating contact points are positioned one above the other in the stacking direction. A method for producing a fuel cell stack is provided. A bipolar plate for a fuel cell stack is also provided.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: July 29, 2014
    Assignee: Staxera GmbH
    Inventor: Andreas Reinert
  • Patent number: 8790845
    Abstract: One embodiment includes a substrate having a plurality of molecular chains, each chain comprising a hydrophilic group, a hydrophobic segment, and a reversible crosslinker.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: July 29, 2014
    Assignee: GM Global Technology Operations LLC
    Inventor: Tao Xie
  • Patent number: 8790846
    Abstract: An object of the present invention is to provide a gas diffusion layer having gas flow passages formed at its one main surface, which is capable of achieving a further improvement in power generation performance. The fuel cell-use gas diffusion layer (14A, 14C) of the present invention has a double-layer structure made up of a first diffusion layer (15A, 15C) having gas flow passages (21A, 21C) at its one main surface, and a second diffusion layer (16A, 16C) disposed on the other main surface of the first diffusion layer. The first diffusion layer and the second diffusion layer are each structured with a porous member mainly comprised of conductive particles and a polymer resin, and the first diffusion layer is structured to be lower in porosity than the second diffusion layer.
    Type: Grant
    Filed: July 2, 2010
    Date of Patent: July 29, 2014
    Assignee: Panasonic Corporation
    Inventors: Masaki Yamauchi, Yoichiro Tsuji
  • Patent number: 8790847
    Abstract: A method of producing a reversible solid oxide cell. The method includes the steps of tape casting an anode support layer on a support (1); tape casting an anode layer on a support (2); tape casting an electrolyte layer on a support (3); and either laminating said anode layer on top of said anode support layer; removing said support (2) from said anode layer; laminating said electrolyte layer on top of said anode layer; and sintering the multilayer structure; or laminating said anode layer on top of said electrolyte layer; removing said support (2) from said anode layer; laminating said anode support layer on top of said anode layer; and sintering the multilayer structure.
    Type: Grant
    Filed: November 21, 2007
    Date of Patent: July 29, 2014
    Assignee: Technical University of Denmark
    Inventors: Peter Halvor Larsen, Karen Brodersen
  • Patent number: 8790848
    Abstract: In fuel cell separator, the periphery of manifold through which fuel gas, reaction water, etc., pass and the seal line being a site of bonding with an adjacent separator are provided with a resin layer. Within the surface of the separator, the resin application site on which the resin layer is formed undergoes subbing treatment in advance to thereby increase the capability of bonding with the resin. When the resin layer consists of a resin having an NH group, as the subbing treatment, hydroxide deposition treatment is carried out on the surface of the separator.
    Type: Grant
    Filed: February 22, 2007
    Date of Patent: July 29, 2014
    Assignee: Toyota Jidosha Kabushiki Kaisha
    Inventors: Yusuke Watanabe, Kazutaka Iizuka
  • Patent number: 8790849
    Abstract: A manufacturing method for an electrode catalyst layer includes: containing a conductive carrier on which a catalyst is supported, a substrate, an electrolyte resin and a supercritical fluid inside a closed container (S102 to S106); and cooling the substrate to form an electrode catalyst layer, having the conductive carrier on which the catalyst is supported and the electrolyte resin, on the substrate (S 108).
    Type: Grant
    Filed: April 8, 2010
    Date of Patent: July 29, 2014
    Assignee: Toyota Jidosha Kabushiki Kaisha
    Inventors: Yuichiro Hama, Takayoshi Doi
  • Patent number: 8790850
    Abstract: A current collection apparatus and its method of processing for a solid oxide fuel cell, which mainly includes using screen printing process to print conductive adhesive onto the surface of the electrode of solid oxide fuel cell (SOFC), forming a current collection layer with drying process, using an appropriate amount of conductive adhesive to paste a conductive wire onto the current collection layer, forming an adhesion layer through drying, fixing the conductive wire on the electrode surface with an appropriate amount of ceramic adhesive, and forming a fixing layer after baking. A good connection is hence made between metal conductive wire and electrode through current collection layer, not only the interface impedance between electrode and current collection layer can be reduced effectively, but also the output power density of the SOFC unit cell can be enhanced, and stable as well as long term power output can be provided.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: July 29, 2014
    Assignee: Institute of Nuclear Energy Research
    Inventors: Jen-Chen Chang, Maw-Chwain Lee, Rung-Je Yang, Tai-Nan Lin, Yang-Chuang Chang, Wei-Xin Kao, Lin-Song Lee
  • Patent number: 8790851
    Abstract: A photo mask for exposing according to an embodiment includes a mark pattern arranged in a mark region that is different from an effective region to form a semiconductor device; and a regular pattern arranged in the mark region and around the mark pattern and smaller than the mark pattern in size and pitch.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: July 29, 2014
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Yosuke Okamoto, Kazutaka Ishigo, Taketo Kuriyama
  • Patent number: 8790852
    Abstract: The present invention provides a colored composition for a light-shielding film including at least one selected from titanium atom-containing black titanium pigments and at least one organic pigment selected from the group consisting of a red organic pigment, a yellow organic pigment, a violet organic pigment, and an orange color organic pigment, which has a maximum value of the transmittance of light having a wavelength of 400 to 700 nm of 1.5% or less when a film is formed such that the light transmittance at a wavelength of 650 nm is 0.2%, has a wavelength showing the maximum transmittance at 400 to 550 nm, and has a light transmittance at a wavelength of 400 nm of 0.1% or more.
    Type: Grant
    Filed: July 7, 2010
    Date of Patent: July 29, 2014
    Assignee: FUJIFILM Corporation
    Inventor: Tatsuya Tanaka
  • Patent number: 8790853
    Abstract: The present disclosure is directed to charge generating compositions and methods of making the charge generating compositions. The composition may comprise one or more polymers comprising styrene units and allyl alcohol units, and one or more photoconductive particles. Electrophotographic devices employing the compositions, including methods of making the devices, are also disclosed.
    Type: Grant
    Filed: March 1, 2006
    Date of Patent: July 29, 2014
    Assignee: Xerox Corporation
    Inventors: Jin Wu, John J. Wilbert, Marc J. Livecchi, Liang-bih Lin
  • Patent number: 8790854
    Abstract: An electrophotographic photoreceptor includes a substrate and a photosensitive layer, wherein the electrophotographic photoreceptor has a surface layer containing fluorine resin particles, and the fluorine resin particles exposed on a surface satisfy the following Expression (1): 0.5?(A)/(B)?10??Expression (1) wherein, (A) represents a number of aggregated particles in which 5 to 20 fluorine resin particles are connected and aggregated, and (B) represents a total number of fluorine resin particles that are isolated without being aggregated and aggregated particles in which 2 to 4 fluorine resin particles are connected and aggregated.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: July 29, 2014
    Assignee: Fuji Xerox Co., Ltd.
    Inventor: Yukimi Kawabata
  • Patent number: 8790855
    Abstract: The present invention provides a charge control agent containing, as an active substance(s), one or two or more thiazolidinedione derivatives represented by the following formula (1), where R1 represents a hydrogen atom, etc.; R2 represents a hydrogen atom, a linear or branched alkyl group having 1 to 8 carbon atoms which may have a substituent, etc.; R3 to R7, which may be identical to or different from each other, represent a hydrogen atom, a chlorine atom, a linear or branched alkyl group having 1 to 8 carbon atoms which may have a substituent, etc., and may be joined to each other to form a ring; and V, W, X, Y and Z represent a carbon atom or a nitrogen atom, and 0 to 3 of any of V, W, X, Y and Z are nitrogen atoms which do not have the substituents of R3 to R7.
    Type: Grant
    Filed: September 1, 2011
    Date of Patent: July 29, 2014
    Assignee: Hodogaya Chemical Co., Ltd
    Inventors: Ikuo Kimura, Motonori Tsuji, Masami Ito, Masaya Tojo, Kanae Hiraishi
  • Patent number: 8790856
    Abstract: The present disclosure describes toner compositions containing an additive package including one or more additives that exhibit low dielectric loss, which toners exhibit improved tribo charging, 2nd transfer efficiency and IQ without affecting color.
    Type: Grant
    Filed: November 9, 2011
    Date of Patent: July 29, 2014
    Assignee: Xerox Corporation
    Inventors: Suxia Yang, Richard P N Veregin, Magid Kamel, Cuong Vong, Kimberly Nosella, Eric Rotberg
  • Patent number: 8790857
    Abstract: Disclosed is a toner obtained by coating surfaces of core particles including at least a binder resin having a carboxyl group and a coloring agent with successive coatings of a water-soluble crosslinking agent capable of crosslinking with a carboxyl group and a water-soluble polymer having a carboxyl group, which have been successively applied on the core particles and crosslinked with each other. The thus-formed toner is provided with a good harmony of favorable fixability represented by a low lowest fixable temperature and favorable storage stability represented by little aggregation after standing at 50° C. for 8 hours.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: July 29, 2014
    Assignee: Toshiba Tec Kabushiki Kaisha
    Inventors: Tsuyoshi Itou, Motonari Udo, Kazuhisa Takeda, Takayasu Aoki, Masahiro Ikuta, Takafumi Hara
  • Patent number: 8790858
    Abstract: An electrostatic charge image developing carrier has magnetic particles and a coating resin layer that coats surfaces of the magnetic particles and contains a hindered amine compound.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: July 29, 2014
    Assignee: Fuji Xerox Co., Ltd.
    Inventors: Toshiaki Hasegawa, Mona Tasaki, Fusako Kiyono
  • Patent number: 8790859
    Abstract: The present invention relates to a photoresist composition for digital exposure and a method of fabricating a thin film transistor substrate. The photoresist composition for digital exposure includes a binder resin including a novolak resin and a compound represented by the chemical formula (1), a photosensitizer including a diazide-based compound, and a solvent: wherein R1-R9 each include a hydrogen atom, an alkyl group, or a benzyl group, a is an integer from 0 to 10, b is an integer from 0 to 100, and c is an integer from 0 to 10.
    Type: Grant
    Filed: November 18, 2009
    Date of Patent: July 29, 2014
    Assignee: Samsung Display Co., Ltd.
    Inventors: Sang-Hyun Yun, Woo-Seok Jeon, Jung-In Park, Hi-Kuk Lee, Byung-Uk Kim, Dong-Min Kim, Seung-Ki Kim, Ja-Hun Byeon
  • Patent number: 8790860
    Abstract: An actinic ray-sensitive or radiation-sensitive resin composition capable of forming a hole pattern which has an ultrafine pore diameter (for example, 60 nm or less) and has an excellent cross-sectional shape with excellent local pattern dimensional uniformity; and a resist film, a pattern forming method, a method for preparing an electronic device, and an electronic device, each using the same, are provided.
    Type: Grant
    Filed: September 11, 2012
    Date of Patent: July 29, 2014
    Assignee: FUJIFILM Corporation
    Inventors: Kosuke Koshijima, Hidenori Takahashi, Shuhei Yamaguchi, Kei Yamamoto
  • Patent number: 8790861
    Abstract: A monomer has the Formula I: wherein R1, R2, and R3 are each independently a C1-30 monovalent organic group, and R1, R2, and R3 are each independently unsubstituted or include a halogen, nitrile, ether, ester, ketone, alcohol, or a combination comprising at least one of the foregoing functional groups; R4 includes H, F, C1-4 alkyl, or C1-4 fluoroalkyl; A is a single bond or a divalent linker group, wherein A is unsubstituted or substituted to include a halogen, nitrile, ether, ester, ketone, alcohol, or a combination comprising at least one of the foregoing functional groups; m and n are each independently an integer of 1 to 8; and x is 0 to 2n+2, and y is 0 to 2m+2.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: July 29, 2014
    Assignee: Rohm and Haas Electronic Materials LLC
    Inventors: Cong Liu, Mingqi Li, Cheng-Bai Xu
  • Patent number: 8790862
    Abstract: The invention provides a photosensitive element and a method for preparing a printing form from the element. The photosensitive element includes a layer of a photosensitive composition containing a binder, a monomer, and a Norrish type II photoinitiator, wherein the photosensitive layer has a transmittance to actinic radiation of less than 20% and contains reinforcing particles of graphene and/or carbon nanotubes.
    Type: Grant
    Filed: January 16, 2013
    Date of Patent: July 29, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventor: Adrian Lungu
  • Patent number: 8790863
    Abstract: In a method for imaging a solid state substrate, a vapor is condensed to an amorphous solid water condensate layer on a surface of a solid state substrate. Then an image of at least a portion of the substrate surface is produced by scanning an electron beam along the substrate surface through the water condensate layer. The water condensate layer integrity is maintained during electron beam scanning to prevent electron-beam contamination from reaching the substrate during electron beam scanning. Then one or more regions of the layer can be locally removed by directing an electron beam at the regions. A material layer can be deposited on top of the water condensate layer and any substrate surface exposed at the one or more regions, and the water condensate layer and regions of the material layer on top of the layer can be removed, leaving a patterned material layer on the substrate.
    Type: Grant
    Filed: October 26, 2011
    Date of Patent: July 29, 2014
    Assignee: President and Fellows of Harvard College
    Inventors: Daniel Branton, Anpan Han, Jene A. Golovchenko
  • Patent number: 8790864
    Abstract: A method of tailoring the shape of a plurality of relief printing dots created in a photosensitive printing blank during a platemaking process is provided. The photocurable layer is exposed to actinic radiation using an array of UV LED light assemblies and the use of the array of UV LED light assemblies produces relief printing dots having at least one geometric characteristic selected from the group consisting of a desired planarity of a top surface of the relief printing dots, a desired shoulder angle of the relief printing dots and a desired edge sharpness of the relief printing dots.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: July 29, 2014
    Inventor: Kyle P. Baldwin
  • Patent number: 8790865
    Abstract: The present disclosure relates to a method of fabricating a capacitive touch pane where a plurality of groups of first conductive patterns are formed along a first direction, a plurality of groups of second conductive patterns are formed along a second direction, and a plurality of connection components are formed on a substrate. Each first conductive pattern is electrically connected to another adjacent first conductive pattern in the same group by each connection component and each group of the second conductive patterns is interlaced with and insulated from each group of the first conductive patterns. Next, a plurality of curved insulation mounds are formed to cover the first connection components. Then, a plurality of bridge components are formed to electrically connect each second conductive pattern with another adjacent second conductive pattern in the same group.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: July 29, 2014
    Assignees: Innocom Technology (Shenzhen) Co., Ltd., Innolux Corporation
    Inventors: Chao-Sung Li, Lien-Hsin Lee, Kai Meng
  • Patent number: 8790866
    Abstract: A negative pattern is formed by coating a resist composition comprising a methylol-substituted urea, amide or urethane compound, a polymer comprising recurring units having an acid labile group-substituted hydroxyl group, and an acid generator onto a substrate, prebaking, exposing to high-energy radiation, and developing in an organic solvent developer such that the unexposed region of resist film is dissolved away and the exposed region of resist film is not dissolved. In image formation via positive/negative reversal by organic solvent development, the resist film is characterized by a high dissolution contrast between the unexposed and exposed regions.
    Type: Grant
    Filed: August 15, 2012
    Date of Patent: July 29, 2014
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Jun Hatakeyama, Kazuhiro Katayama, Tomohiro Kobayashi
  • Patent number: 8790867
    Abstract: Provided are methods of forming photolithographic patterns by negative tone development. The methods employ a photoresist composition that includes a polymer having a unit of the following general formula (I): wherein: R1 represents hydrogen or a C1 to C3 alkyl group; a represents an integer from 1 to 3; and b represents 0 or 1. The methods find particular applicability in the manufacture of semiconductor devices.
    Type: Grant
    Filed: November 3, 2012
    Date of Patent: July 29, 2014
    Assignee: Rohm and Haas Electronic Materials LLC
    Inventors: Young Cheol Bae, Jibin Sun, Seung-Hyun Lee, Jong Keun Park, Cecily Andes
  • Patent number: 8790868
    Abstract: A method of forming a resist pattern, the method including: forming a resist film on a substrate using a resist composition containing a base component (A) that exhibits reduced solubility in an organic solvent under the action of acid, an acid generator component (B) that generates acid upon exposure and a fluorine-containing polymeric compound (F), exposing the resist film, and patterning the resist film by negative tone development using a developing solution containing the organic solvent, thereby forming a resist pattern, wherein the base component (A) contains a resin component (A1) containing a structural unit (a1) derived from an acrylate ester, the dissolution rates of (A1) and (F) in the developing solution are each at least 10 nm/s, and the absolute value of the difference in the dissolution rates of (A1) and (F) in the developing solution is not more than 80 nm/s.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: July 29, 2014
    Assignee: Tokyo Ohka Kogyo Co., Ltd.
    Inventors: Hiroaki Shimizu, Hideto Nito
  • Patent number: 8790869
    Abstract: Disclosed herein is a method of identifying a tumor biomarker. In one example, a tumor biomarker is identified by obtaining a peripheral biological fluid sample from a subject with a tumor as well as a tumor sample and an adjacent non-tumor sample from such subject. A protein expression profile is detected in the peripheral biological fluid sample, tumor sample and adjacent non-tumor sample. The protein expression profiles of the peripheral biological fluid sample, tumor sample and adjacent non-tumor sample are then compared, wherein an increase in expression of a specific protein in the tumor sample and peripheral biological fluid sample but not in the adjacent non-tumor sample indicates that the specific protein is a biomarker of the tumor. Also disclosed herein is a gene profiling signature that can be used to diagnosis a subject with renal cell carcinoma (RCC) or to identify agents with therapeutic potential to treat RCC. Thus, methods of diagnosing a subject with RCC are disclosed.
    Type: Grant
    Filed: March 20, 2009
    Date of Patent: July 29, 2014
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Josip Blonder, Bih-Rong Wei, Donald J. Johann, Timothy D. Veenstra
  • Patent number: 8790870
    Abstract: The present invention concerns a method for predicting quantitative phenotype, e.g. gag-phenotype, integrase phenotype or tropism in a patient infected by Human Immunodeficiency Virus (HIV).
    Type: Grant
    Filed: February 2, 2007
    Date of Patent: July 29, 2014
    Assignee: Virco BVBA
    Inventors: Lieven Jozef Stuyver, Kurt Van Baelen, Ina Isabel Vandenbroucke
  • Patent number: 8790871
    Abstract: Disclosed herein are methods of detecting and predicting diastolic heart failure and predicting congestive heart failure comprise protease and protease inhibitor profiling.
    Type: Grant
    Filed: April 24, 2007
    Date of Patent: July 29, 2014
    Assignee: MUSC Foundation for Research Development
    Inventors: Francis G. Spinale, Robert E. Stroud, Michael R. Zile
  • Patent number: 8790872
    Abstract: A method of detecting the production of an analyte by cells in a sample, which method comprises: (i) providing an antibody capable of binding to said analyte and a first agent capable of enhancing detection of said analyte, wherein said antibody and said first agent are immobilized on the same support; (ii) contacting said antibody and said agent with a sample of cells; and (iii) detecting binding of said analyte to said antibody thereby detecting the production of an analyte by cells in a sample.
    Type: Grant
    Filed: April 29, 2005
    Date of Patent: July 29, 2014
    Assignee: Mabtech AB
    Inventors: Staffan Paulie, Sten Braesch-Andersen
  • Patent number: 8790873
    Abstract: Disclosed are methods and compositions for detection and amplification of nucleic acids, wherein two DNA strands hybridized to an RNA strand are ligated. In one aspect, the disclosed methods include removal of an energy source, such as ATP, upon charging a ligase to form an enzyme-AMP intermediate, and then adding substrate, which results in one complete round of RNA-templated DNA ligation. In another aspect, the ligation reaction is accomplished by use of a mixture of at least two different ligase enzymes. The disclosed methods and compositions for RNA-templated DNA ligation may be particularly useful for detection of RNA sequence variants, for example RNA splice variants, and for quantitative expression analysis.
    Type: Grant
    Filed: January 19, 2010
    Date of Patent: July 29, 2014
    Assignee: Affymetrix, Inc.
    Inventors: Eugeni A. Namsaraev, Xin Miao, John E. Blume
  • Patent number: 8790874
    Abstract: A device for investigation of a flow conduit comprising: a base; and a module formed in the base, the module comprising: a main channel for the flow conduit, the main channel having a loading inlet for loading the flow conduit; a culture chamber in the main channel for at least one of perfusion and superfusion of the flow conduit; at least two fixation lines in communication with the main channel for providing fixation of the flow conduit at at least two fixation locations along the length of the flow conduit.
    Type: Grant
    Filed: June 17, 2009
    Date of Patent: July 29, 2014
    Inventors: Axel Guenther, Steffen-Sebastian Bolz
  • Patent number: 8790875
    Abstract: Single nucleotide polymorphic sites of the bovine HSP genes are associated with improved fertilization rate and/or improved embryo survival rate in cattle. Nucleic acid molecules, kits, methods of genotyping and marker assisted bovine breeding methods based on these SNPs are disclosed.
    Type: Grant
    Filed: August 1, 2012
    Date of Patent: July 29, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Hasan Khatib
  • Patent number: 8790876
    Abstract: An apparatus and method for performing rapid DNA sequencing, such as genomic sequencing, is provided herein. The method includes the steps of preparing a sample DNA for genomic sequencing, amplifying the prepared DNA in a representative manner, and performing multiple sequencing reaction on the amplified DNA with only one primer hybridization step.
    Type: Grant
    Filed: April 20, 2007
    Date of Patent: July 29, 2014
    Assignee: 454 Life Sciences Corporation
    Inventors: John H. Leamon, Kenton L. Lohman, Jonathan M. Rothberg, Michael P. Weiner
  • Patent number: 8790877
    Abstract: The solutions provided here use DNA aptamers and quantum dots for the detection of bacteria, viruses, proteins or other targets. An example of a method described here comprises: providing a complex of DNA complementary strands, one strand being an aptamer, having one strand covalently linked to a quantum dot, and having the other strand linked to a quencher; and contacting the complex of DNA complementary strands with a microorganism or components thereof, under conditions that permit binding of the aptamer with the microorganism or components thereof.
    Type: Grant
    Filed: July 9, 2008
    Date of Patent: July 29, 2014
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Eric A. Holwitt, Jonathan L. Kiel, Veronica Franz Sorola
  • Patent number: 8790878
    Abstract: The present invention relates to compositions and methods for determining a treatment course of action. In particular, the present invention relates to compositions and methods for the prediction of a subject's response to cancer therapies and administration of appropriate treatments.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: July 29, 2014
    Assignee: The Regents of The University of Michigan
    Inventor: Daniel Hayes
  • Patent number: 8790879
    Abstract: Oligonucleotides useful for determining the presence of Trichomonas vaginalis in a test sample.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: July 29, 2014
    Assignee: Gen-Probe Incorporated
    Inventors: Damon Kittredge Getman, Barbara Susan Weinbaum
  • Patent number: 8790880
    Abstract: Accurate and fast detection of the presence of Clostridium difficile (C. difficile) disease is crucial for the proper treatment of patients with C. difficile infection. Present tests detecting the presence of C. difficile disease are fast and cost effective, but are not very sensitive. Using an ELISA including Cell Wall Protein 84 (Cwp84) increases the sensitivity of the ELISA. Cwp84 may be used alone or in combination with other markers to support a diagnosis of C. difficile-associated disease.
    Type: Grant
    Filed: September 25, 2012
    Date of Patent: July 29, 2014
    Assignee: Techlab, Inc.
    Inventors: Manli Y. Davis, David M. Lyerly, Tracy D. Wilkins
  • Patent number: 8790881
    Abstract: A method for measuring immunoglobulin G-mediated complement activation, includes the following steps: a) preparing a sample A of immunoglobulin G and a sample B including natural serum, the natural serum optionally being diluted in a dilution buffer; b) mixing sample A with sample B at a ratio (amount of IgG in A in grams):(volume of natural serum in B in liters) of between and 75, at a temperature of between 2° C. and 6° C., and subsequently incubating the resulting reaction mixture at a temperature of between 35° C. and 40° C. for a period of between 30 minutes and 2 hours; c) cooling the reaction mixture obtained at the end of step b) to a temperature of between 0° C. and 4° C. in the presence of EDTA; and d) measuring the amount of C5a fragment in the cooled reaction mixture obtained in c).
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: July 29, 2014
    Assignee: Laboratoire francais du Fractionnement et des Biotechnologies
    Inventors: Frederic Dhainaut, Gerald Perret
  • Patent number: 8790882
    Abstract: The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic antibody:antigen complexes, soluble antigens or soluble therapeutic antibodies may be measured and used to stage or monitor a hyperproliferative disease.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: July 29, 2014
    Assignee: Board of Regents, The University of Texas System
    Inventors: Maher Albitar, Michael J. Keating, Taghi Manshouri
  • Patent number: 8790883
    Abstract: The present invention relates to polypeptides that inhibit the NF-?B signaling pathway and polynucleotides encoding the same. The present invention further provides methods for the modulation of and/or treatment of inflammatory responses, oncogenesis, viral infection; the regulation of cell proliferation and apoptosis; and regulation of B or T lymphocytes in antigenic stimulation, by administering the polypeptides of the present invention to a subject in need thereof. Finally, the present invention provides a method of identifying polypeptides that modulate oligomerization of NEMO.
    Type: Grant
    Filed: April 24, 2008
    Date of Patent: July 29, 2014
    Assignee: Institut Pasteur
    Inventors: Fabrice Agou, Gilles Courtois, Alain Israel, Michel Vernon, Francois Traincard, Shoji Yamaoka
  • Patent number: 8790884
    Abstract: A method for measuring the amount of sialic acid in immunoglobulin G and immunoglobulin G anti-ds DNA antibodies is disclosed. The method for measuring the amount of sialic acid in immunoglobulin G in the present invention uses culture fluid, blood, plasma, or serum to directly measure the amount of sialic acid in immunoglobulin G. Also, using a mouse monoclonal antibody immunoglobulin G as a standard, which is diluted from 1000 ng/ml to 15.625 ng/ml in phosphate buffered saline (PBS), produces good results. The method for measuring the amount of sialic acid in immunoglobulin G anti-ds DNA antibodies has never been done and the present invention produces good results as well.
    Type: Grant
    Filed: January 7, 2013
    Date of Patent: July 29, 2014
    Assignee: Chang Gung Medical Foundation, Linkou Branch
    Inventor: Lieh-bang Liou
  • Patent number: 8790885
    Abstract: Disclosed is a technique for obtaining a coagulogen raw material which can irreversibly inactivate the activity of a coagulase while retaining the function of coagulogen in an LAL reagent, a LAL reagent contaminated by an organism-derived biologically active substance or the like, and which can be used in a reagent. An LAL reagent is heated at a predetermined temperature for a predetermined period of time to deactivate only the activity of an enzyme contained in the LAL reagent irreversibly, wherein such an activity inherent in coagulogen that coagulogen can be hydrolyzed with the activated coagulase and converted to coagulin to induce gelatinization or an agglutination reaction is retained.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: July 29, 2014
    Assignee: Kowa Company, Ltd.
    Inventor: Katsumi Yabusaki
  • Patent number: 8790886
    Abstract: Methods to assay kinase activity are provided herein. The methods employ elemental analysis, including inductively charged plasma mass spectrometry (ICP-MS). The methods allow for the convenient and accurate analysis of post-translation modifications of substrates by kinase enzymes involved in post-translational modifications.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: July 29, 2014
    Assignee: Fluidigm Canada Inc.
    Inventor: Olga Ornatsky
  • Patent number: 8790887
    Abstract: The invention relates to the field of disorders of the peripheral or central nervous system, in particular, Alzheimer's disease, and the prevention and/or treatment thereof. In particular, the invention relates to ARF6 and/or ARF6 effector proteins as new targets in Alzheimer's disease, and based thereon, screening methods for compounds that reduce amyloid beta peptide formation in mammalian cells by affecting ARF6-mediated endosomal sorting.
    Type: Grant
    Filed: December 6, 2010
    Date of Patent: July 29, 2014
    Assignees: VIB VZW, Katholieke Universiteit Leuven, K.U. Leuven R&D
    Inventors: Wim Annaert, Ragna Sannerud, Katrijn Coen, Bart De Strooper
  • Patent number: 8790889
    Abstract: A method of activating a latent neural precursor cell population, comprising: (1) providing a neural cell population derived from the hippocampus; (2) introducing the neural cell population to a neurosphere-forming culture medium; and (3) activating the latent precursor cell population by treatment with a ?3 adrenergic receptor agonist.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: July 29, 2014
    Assignee: The University of Queensland
    Inventors: Dhanisha Jhaveri, Perry Francis Bartlett