Patents Issued in March 31, 2015
  • Patent number: 8993477
    Abstract: The present invention relates to a catalyst composition and a catalyst material produced therefrom for the steam reforming of methane in fuel cells, in particular for the direct internal reforming of methane in molten carbonate fuel cells. The invention further relates to a process for producing such catalyst compositions.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: March 31, 2015
    Assignee: BASF SE
    Inventors: Andrian Milanov, Ekkehard Schwab, Alexander Schäfer
  • Patent number: 8993478
    Abstract: The present invention provides a method for producing an activated carbon for an electric double layer capacitor, with which the wettability of a carbon material with an alkali activator is improved, thereby improving contact efficiency between the carbon material and the alkali activator and efficiently promoting reaction between the carbon material, which is a starting material and the activator. The method comprises adjusting a carbon material as it is or after having been calcined to produce a carbon powder having an average particle diameter of 0.5 to 15 ?m, oxidizing the carbon powder to contain 3 percent by mass or more of oxygen, and activating the oxidized product with an alkali activator.
    Type: Grant
    Filed: December 24, 2010
    Date of Patent: March 31, 2015
    Assignee: JX Nippon Oil & Energy Corporation
    Inventors: Masaki Fujii, Noriyuki Kiuchi, Shinya Taguchi, Keizo Ikai
  • Patent number: 8993479
    Abstract: The present invention relates to a process for modifying or functionalizing oxide surfaces, such as surfaces of SiO2 and Al2O3, but also metals including alloys such as stainless steel with alkenes or alkynes under mild conditions by photochemical reaction. The process is very well suited to form patterned modified surfaces which are of use for example in microelectronics, biosensing and catalysis.
    Type: Grant
    Filed: October 16, 2009
    Date of Patent: March 31, 2015
    Assignee: Surfix BV
    Inventors: Johannes Teunis Zuilhof, Jurjen ter Maat
  • Patent number: 8993480
    Abstract: Agrochemical compositions comprising at least one active compound from the class of the anthranilamides and at least one further active compound selected from the group consisting of insecticides, fungicides, and/or acaricides have excellent synergistic activity.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: March 31, 2015
    Assignee: Bayer CropScience AG
    Inventors: Christian Funke, Rüdiger Fischer, Reiner Fischer, Wolfgang Thielert, Anton Kraus, Heike Hungenberg
  • Patent number: 8993481
    Abstract: Provided is a method which exerts an excellent effect in controlling a pest in a field of soybean, corn or cotton, using a SDHI compound and a PPO-inhibiting compound.
    Type: Grant
    Filed: November 27, 2012
    Date of Patent: March 31, 2015
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Yoshinao Sada
  • Patent number: 8993482
    Abstract: The present invention relates to a composition of granulated or pelletized endomycorrhizal fungi spores coated with a covering of mineral clays and binders with calcium sulphate monohydrate and the production and use thereof in agriculture.
    Type: Grant
    Filed: October 25, 2010
    Date of Patent: March 31, 2015
    Inventor: José Luis Miranda Valencia
  • Patent number: 8993483
    Abstract: The invention relates to novel insecticidal active compound combinations comprising, firstly, compounds which act as insecticides on nicotinergic acetylcholine receptors as agonists and antagonists, and at least one active compound from the group of the anthranilamides, which combinations are suitable for protecting plants against attack by pests.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: March 31, 2015
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Christian Funke, Reiner Fischer, Rüdiger Fischer, Heike Hungenberg, Wolfram Andersch, Wolfgang Thielert, Anton Kraus
  • Patent number: 8993484
    Abstract: Methods of improving the growth of a plant by applying a plant growth effective amount of a plant growth composition that includes a hydrated aluminum-magnesium silicate and at least one dispersant selected from the group consisting of a sucrose ester, a lignosulfonate, an alkylpolyglycoside, a naphthalenesulfonic acid formaldehyde condensate and a phosphate ester to plant propagation material in the absence of insect pest pressure.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: March 31, 2015
    Assignee: FMC Corporation
    Inventors: Timothy M. Martin, Frank Zawacki
  • Patent number: 8993485
    Abstract: Disclosed is a splicing method of two second-generation ReBCO high temperature superconductor coated conductors (2G ReBCO HTS CCs), in which, with stabilizing layers removed from the two strands of 2G ReBCO HTS CCs through chemical wet etching or plasma dry etching, surfaces of the two high temperature superconducting layers are brought into direct contact with each other and heated in a splicing furnace in a vacuum for micro-melting portions of the surfaces of the high temperature superconducting layers to permit inter-diffusion of ReBCO atoms such that the surfaces of the two superconducting layers can be spliced to each other and oxygenation annealing for recovery of superconductivity which was lost during splicing.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: March 31, 2015
    Assignee: K.Joins
    Inventors: Young-Kun Oh, Hee-Sung Ann, Myung-Whon Lee, Hai-Gun Lee
  • Patent number: 8993486
    Abstract: Synergy occurs when combined agents induce a response greater than the sum of their individual effects. The present invention provides new high throughput screening methods to detect agents acting synergistically in orthogonally pooled mixtures. Computational de-convolution of the pooled data with software reveals single-actives in the pools with twice the statistical power and with much greater efficiency than common high throughput screening approaches. Cross-correlating the orthogonal data reveals pools with activity that cannot be ascribed to any single compound. The components of such ‘Orphan’ activity pools are then tested individually and in all possible combination-pairs to identify and confirm synergy.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: March 31, 2015
    Inventors: Melvin Reichman, Preston Scott Donover
  • Patent number: 8993487
    Abstract: A bio-disc device including new valve control means and fluid movement system, a bio-driver apparatus in which a controller disc including a controller for the bio-disc is installed, and an assay method using the same, which are suitable for labs-on-a-chips for various diagnostic assays, nucleic acid hybridization assays, and immunoassays, are provided. The bio-driver apparatus is compatible with general optical discs, including audio CDs, CD-Rs, game CDs, DVDs, etc., and the assay method is compatible with general optical disc drivers, including CD-ROMs, DVD players, etc. Thus, the bio-driver apparatus and the assay method offer and economical and convenient alternative to existing products. In addition, the bio-driver apparatus can be readily and easily applied in connection with a computer for remote diagnosis via the Internet.
    Type: Grant
    Filed: May 2, 2006
    Date of Patent: March 31, 2015
    Assignee: Samsung Electronics Co., Ltd.
    Inventor: Jae Chern Yoo
  • Patent number: 8993488
    Abstract: A method and system remove hydrogen sulfide from a hydrocarbon containing fluid. In an embodiment, the method for removing hydrogen sulfide from a hydrocarbon containing fluid includes contacting a methylmorpholine-N-oxide solution with the hydrocarbon containing fluid. The method also includes allowing the methylmorpholine-N-oxide to react with the hydrogen sulfide to remove the hydrogen sulfide.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: March 31, 2015
    Assignee: United Laboratories International, LLC
    Inventors: Jack G. Frost, Stephen D. Matza, Martha T. Smith
  • Patent number: 8993489
    Abstract: Solid proppants are coated with a phenol-urethane coating in one or more layers by a method comprising coating a proppant solid and then curing the coated proppant under conditions sufficient to substantially cure said proppant, wherein said coating comprises a substantially homogeneous mixture of (i) an isocyanate component having at least 2 isocyanate groups, (ii) an amine reactant, and optionally (iii) an amine that is a latent curing agent for said isocyanate.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: March 31, 2015
    Assignee: Preferred Technology, LLC
    Inventors: Robert Ray McDaniel, Avis Lloyd McCrary
  • Patent number: 8993490
    Abstract: The present invention relates to environmentally friendly compositions and methods for removing or suppressing metal ions in waters, flowback waters, and produced waters to make such waters suitable for subsequent use in oil-field applications and for delinking metal cross-linked gelling agents. One embodiment of the present invention provides a method of providing a competitive binder and allowing the competitive binder to interact with interfering metal ions in a flowback fluid to suppress or remove interfering metal ions.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: March 31, 2015
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Rajesh K. Saini, Jeremy Holtsclaw, David M. Loveless, Lucas K. Fontenelle, Prajakta R. Patil, Ramesh Muthusamy
  • Patent number: 8993491
    Abstract: Compositions that swell on contact with water contain a non-swellable thermoplastic or thermoset polymer and a swellable inorganic compound. In particular, the compositions are suitable for use in subterranean wells such as those used in the oil and gas industry. The polymer may be polypropylene and the inorganic compound may be magnesium oxide.
    Type: Grant
    Filed: April 23, 2009
    Date of Patent: March 31, 2015
    Assignee: Schlumberger Technology Corporation
    Inventors: Simon James, Bruno Drochon
  • Patent number: 8993492
    Abstract: A crosslinking composition for hydrocarbon gels containing phosphate ester gelling agents comprising a modified imidazoline or pyrimidine including an alkyl group (or unsaturated carbon chain) or of 10 to 22 carbon atoms, a polyamine, and ferric sulfate. The method of making the crosslinking agent features adding the polyamine after reaction of the other ingredients; unique gels formed with the crosslinking agent are particularly effective for LNG at very cold temperatures.
    Type: Grant
    Filed: August 14, 2012
    Date of Patent: March 31, 2015
    Assignee: CST Performance Products Corp.
    Inventors: Larry W. Gatlin, Glen E. Walden, Ernest McMillan
  • Patent number: 8993493
    Abstract: Sliding parts are made of Pb-free Cu—Bi based sintered material. The side in contact with a shaft is machined to a predetermined roughness. A number of Bi phases are present on the finished surface. Stable performance of Bi is to be exhibited. Machined sintered material covers a portion of the Bi phases. The ratio of the exposed surface area of the Bi phases is 0.5% or more relative to the area of the finished surface.
    Type: Grant
    Filed: September 9, 2009
    Date of Patent: March 31, 2015
    Assignee: Taiho Kogyo Co., Ltd.
    Inventors: Ryo Mukai, Hiromi Yokota, Kao Mouri
  • Patent number: 8993494
    Abstract: Compositions containing a reverse micelle comprising a first compound and a second compound are disclosed, wherein the second compound is configured to change conformation in response to a stimulus, a first conformation selected for formation of the reverse micelle, and a second conformation selected for disruption of the reverse micelle; and wherein the first compound is selected to interact with the first conformation of the second compound to form the reverse micelle.
    Type: Grant
    Filed: December 1, 2010
    Date of Patent: March 31, 2015
    Assignee: Empire Technology Development LLC
    Inventor: Takahisa Kusuura
  • Patent number: 8993495
    Abstract: A novel composition is provided that incorporates the residual solids from solvent deasphalting to make a high value asphalt product. A process for making the asphalt composition is also provided. A first portion of heavy oil or another feedstock can be deasphalted using propane deasphalting or another suitable deasphalting process. This generates a solvated fraction and an insoluble deasphalting residue. The deasphalting residue is then added to a second portion of heavy oil, such as a second portion of the same type of heavy oil that was used as feedstock in the solvent deasphalting. The mixture of deasphalting residue and heavy oil results in a novel dispersion that is suitable for use as an asphalt. Optionally, an additive such as an alkyl substituted aromatic sulfonic acid can be added to the composition to further improve the asphalt properties.
    Type: Grant
    Filed: December 2, 2011
    Date of Patent: March 31, 2015
    Assignee: ExxonMobil Research and Engineering Company
    Inventors: Ramesh Varadaraj, Lyle E. Moran, John Brownie, Mary J. Gale
  • Patent number: 8993496
    Abstract: Disclosed is a method for improving compatibility of a fluorocarbon elastomer seal with a lubricating oil composition containing (a) a major amount of a base oil of lubricating viscosity; and (b) one or more dispersants containing one or more basic nitrogen atoms. The method involves adding to the lubricating oil composition an effective amount of one or more fluorocarbon elastomer compatibility improving agents comprising one or more oil-soluble titanium compounds.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: March 31, 2015
    Assignee: Chevron Oronite Company LLC
    Inventors: Kenneth D. Nelson, Elaine S. Yamaguchi, Kam-Sik Ng, Paula S. Rogers
  • Patent number: 8993497
    Abstract: The present invention provides a grease composition which has excellent conductivity and can rapidly remove static electricity generated by using a bearing. The grease composition comprises a base oil, a thickener and a tungsten disulfide powder, wherein the average particle diameter of the tungsten disulfide powder is 0.5 to 5.0 ?m and the amount of tungsten disulfide powder based on 100 parts by mass of the total amount of base oil and thickener is 2.0 to 4.0 parts by mass.
    Type: Grant
    Filed: November 23, 2012
    Date of Patent: March 31, 2015
    Assignee: Nippon Grease Co., Ltd.
    Inventors: Hiroki Iwamatsu, Kenji Yuki, Masahiro Okumiya
  • Patent number: 8993498
    Abstract: A continuously variable transmission oil composition comprising a base oil and at least one phosphorous compound in such an amount that the phosphorus in the phosphorus compound accounts for 0.005 to 0.15 mass % of the total mass of the composition and wherein the continuously variable transmission oil composition has a friction coefficient from 0.146 to 0.164 when tested according to ASTM D2714.
    Type: Grant
    Filed: February 8, 2010
    Date of Patent: March 31, 2015
    Assignee: JX Nippon Oil & Energy Corporation
    Inventors: Yoshitaka Manabe, Shin Saeki
  • Patent number: 8993499
    Abstract: A carboxylate detergent prepared by the process comprising (a) alkylating a hydroxyaromatic compound with at least one normal alpha olefin having from about 12 to about 30 carbon atoms per molecule that has been isomerized to obtain an isomerized alpha olefin having 15-98 wt % branching and a residual alpha olefin content of between from about 0.1 to about 30 wt %, thereby producing an alkylated hydroxyaromatic compound; (b) neutralizing the resulting alkylated hydroxyaromatic compound with an alkali metal base; (c) carbonating the alkali metal salt from step (b) with carbon dioxide; (d) acidifying the salt produced in step (c); and (e) overbasing the resulting alkylated hydroxyaromatic carboxylic acid.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: March 31, 2015
    Assignees: Chevron Oronite Company LLC, Chevron Oronite S.A.
    Inventors: Curt B. Campbell, Gilles P. Sinquin, Eugene E. Spala, Gilbert R. Chapon
  • Patent number: 8993500
    Abstract: The invention relates to a liquid cleaning and disinfecting hand dishwashing detergent composition comprising at least one surfactant selected from the group consisting of anionic, nonionic, cationic, zwitterionic, amphoteric surfactants, and mixtures thereof, at least one organic solvent and/or at least one hydrotrope, and a single antibacterial active and/or at least one sequestering agent. The cleaning and disinfecting hand dishwashing detergent composition eliminates 99.999% of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Enterococcus hirae in no more than 5 minutes at an 80% product concentration and 20 degrees Celsius according to the EN1276 suspension test The present invention further relates to methods of cleaning and disinfecting dishware and/or dishwashing implements and/or skin using such a liquid of cleaning and disinfecting detergent composition.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: March 31, 2015
    Assignee: The Procter & Gamble Company
    Inventors: Jamila Tajmamet, Robby Renilde François Keuleers, Marie-Emile Lascaux, Shruti Amar Sachdev, Vaishali Shailendra Rane
  • Patent number: 8993501
    Abstract: A sprayable homogeneous and high viscosity surface cleaning gel or gel foam composition and method of cleaning is provided. The composition may include from about 70% to about 99% of a liquid carrier; from about 0.002% to about 10% of surfactant selected from the group of non-ionic, anionic, amphoteric, and zwitterionic surfactants, and mixtures thereof; from about 0.005% to about 5% of a water-soluble polymeric thickening agent; and from about 0.001 to about 1.0% of a pH balancing agent. The sprayable gel cleaner composition may be completely clear without any suspended encapsulated particles in it and includes a viscosity range from about 200 centipoise to about 30,000 centipoise at standard temperature and pressure.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: March 31, 2015
    Assignee: Visichem Technology, Ltd.
    Inventor: Brij P. Singh
  • Patent number: 8993502
    Abstract: A composition for treating a hard surface. The composition has: (a) at least one adhesion promoter; (b) at least one surfactant selected from the group consisting of: anionic, non-ionic, cationic, amphoteric, zwitterionic, and combinations thereof; (c) mineral oil; (d) a blend of linear primary alcohols, wherein each alcohol of said blend includes a carbon chain containing 9 to 17 carbons or an ethoxylated blend thereof; (e) water; (f) optionally, at least one solvent; and wherein the composition is self-adhering upon application to a surface to be treated, and wherein the composition provides a wet film to said surface when water passes over said composition and surface.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: March 31, 2015
    Assignee: S. C. Johnson & Son, Inc.
    Inventors: Michael E. Klinkhammer, Russell B. Wortley, Thomas A. Strash
  • Patent number: 8993503
    Abstract: A liquid detergent comprising from about 5% to about 20% by weight thereof of a surfactant system wherein the surfactant system comprises an alkoxylated anionic surfactant having and alkoxylation degree of from 0.20 to 1.75 and wherein the detergent at 20° C. has a pouring viscosity of from about 2500 mPa s to about 6000 mPa s and a ratio of medium to high shear viscosity of from about 2 to about 1.
    Type: Grant
    Filed: January 16, 2014
    Date of Patent: March 31, 2015
    Assignee: The Procter & Gamble Company
    Inventors: Robby Renilde Francois Keuleers, Kelly Paula August Merckx
  • Patent number: 8993504
    Abstract: The present invention provides an oxidation catalyst for bleaching containing a component (a) which is an anion caused from a chelating agent having less than or equal to coordination position 5 and/or the chelating agent, and a component (b) which is a copper and/or manganese compound; and a binder compound (c); a hydrogen peroxide-based compound (d) which dissolves in water and generates hydrogen peroxide, the bleaching composition containing a granulated product or a molded product in which at least the component (b) and the component (c) are granulated or molded together. According to the invention, an oxidation catalyst that promotes the oxidation effect of hydrogen peroxide-based compounds with a trace amount of the composition, and has excellent effects of suppressing the decomposition of hydrogen peroxide-based compounds and suppressing coloration of the catalyst itself, and a bleaching composition containing the oxidation catalyst can be utilized.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: March 31, 2015
    Assignee: LION Corporation
    Inventors: Takayasu Kubozono, Tomonari Suekuni, Yosuke Kono, Yukiko Iwasa, Hideyuki Kaneda, Yukihiro Dannoue, Hiroaki Hara, Yasushi Hirata
  • Patent number: 8993505
    Abstract: The invention relates to compositions and methods of treatment employing compositions comprising polyelectrolyte complexes. The compositions include a water-soluble first polyelectrolyte bearing a net cationic charge or capable of developing a net cationic charge and a water-soluble second polyelectrolyte bearing a net anionic charge or capable of developing a net anionic charge. The total polyelectrolyte concentration of the first solution is at least 110 millimolar. The composition is free of coacervates, precipitates, latex particles, synthetic block copolymers, silicone copolymers, cross-linked poly(acrylic) and cross-linked water-soluble polyelectrolyte. The composition may be a concentrate, to be diluted prior to use to treat a surface.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: March 31, 2015
    Assignee: The Clorox Company
    Inventors: David R. Scheuing, Thomas F. Fahlen, Jared Heymann, Mike Kinsinger, William Ouellette, William L. Smith
  • Patent number: 8993506
    Abstract: A hydrophilized article includes (a) a substrate having a hydrophobic surface, and (b) a hydrophilizing layer disposed on at least a portion of the hydrophobic surface of the substrate. said layer comprising an organophosphorus material or a vinyl alcohol material, or a mixture of an organophosphorus material and a vinyl alcohol material.
    Type: Grant
    Filed: June 12, 2007
    Date of Patent: March 31, 2015
    Assignee: Rhodia Operations
    Inventors: Tobias Johannes Fütterer, Robert Lee Reierson, Jean-Christophe Castaing
  • Patent number: 8993507
    Abstract: Functional additives for cleansing compositions exhibiting enhanced anti soil-re-deposition and/or dye transfer inhibitory properties comprising polymers in the form of homopolymers, copolymers or terpolymers synthesized from at least one hydrophobic monomer. Examples of hydrophobic monomers include N-vinyl caprolactam, vinyl acetate, vinyl esters, acrylated glycols, methacrylamide, C1 to C12 alkyl- and C1 to C12 dialkylacrylamide, C1 to C12 alkyl- and C1 to C12 dialkylmethacrylamide, C1 to C12 alkyl aery late, C1 to C12 alkyl methacrylate, 4-butyl phenyl maleimide, octyl acrylamide.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: March 31, 2015
    Assignee: ISP Investments Inc.
    Inventors: David K. Hood, Karyn B. Visscher, Tony Gough, Surya Kamin, Purvita Shah, Jayanti V. Patel, Sarah Orton, Osama M. Musa
  • Patent number: 8993508
    Abstract: The present invention relates to a laundry care composition comprising from 0.00001 wt % to 0.5 wt % mono-azo carboxylate dye having the structure of Formula I: wherein each R3 is independently selected from the group consisting of alkyl, oxyalkyl, oxyaryl, sulfonamidoalkyl, sulfonamidoaryl, amidoalkyl, amidodialkyl, amidoaryl, amidodiaryl, halogen, thioalkyl and thioaryl; wherein the index a is an integer from 0 to 4, preferably from 0 to 2; wherein D is an aromatic or heteroaromatic group, with the proviso that the heteroaromatic group is not a thiophene; wherein R1 is independently selected from the group consisting of: (a) unsubstituted or substituted C1 to C12 alkyl chains, optionally the alkyl chains comprise ether (C—O—C), ester and/or amide links, optionally the alkyl chains are substituted with —Cl, —Br, —CN, —NO2, —SO2CH3, —OH and mixtures thereof; and (b) (CH2CH2O)y((CH2)wNH)zQ; wherein R2 is (CH2CH2O)y?((CH2)w?NH)z?Q?.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: March 31, 2015
    Assignee: The Procter & Gamble Company
    Inventor: Gregory Scot Miracle
  • Patent number: 8993509
    Abstract: The present invention relates to agents, and methods for identifying compounds, which agents and compounds are effective in the treatment, and more particularly, that inhibit cachexia, and its associated or related disorders and conditions. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by cachexia, and its associated or related disorders and conditions and/or cachexia, and its associated or related disorders and conditions, such as for example, cancer cachexia and cachexia associated with AIDS, autoimmune disorders, drug addiction, alcoholism, chronic inflammatory disorders, cirrhosis of the liver, anorexia and neurodegenerative disease. In particular, the diagnostic marker and drug target of the invention is the ATGL Lipase, which can be inhibited by e.g. siRNAs and compounds with any of the following structures (I).
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: March 31, 2015
    Inventors: Robert Zimmerman, Rudolf Zechner, Günther Haemmerle, Gerald Höfler, Suman Das, Achim Lass
  • Patent number: 8993510
    Abstract: Peptides having at least 2 amino acids and no more than 15 amino acids are provided. The peptides comprise amino acid sequence X-Y or Y-X, wherein X is an aromatic amino acid and Y is any amino acid other than glycine. Also provided are pharmaceutical compositions and kits including such peptides as well as methods using same for diagnosing and treating amyloid associated diseases.
    Type: Grant
    Filed: August 26, 2013
    Date of Patent: March 31, 2015
    Assignee: Tel Aviv University Future Technology Development L.P.
    Inventor: Ehud Gazit
  • Patent number: 8993511
    Abstract: This application describes a family of compounds acting as ?-arrestin effectors. Such compounds may provide significant therapeutic benefit in the treatment of chronic and acute cardiovascular diseases.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: March 31, 2015
    Assignee: Trevena, Inc.
    Inventors: Dennis Yamashita, Xiao-Tao Chen
  • Patent number: 8993512
    Abstract: A method and composition for the treatment of ischemic neuronal reperfusion injury are provided. The composition can include a compound which is a combination of dantrolene and a residue of FMOC-valine. This composition can be used to provide a faster and higher CNS penetration than heretofore experienced with dantrolene. In another form, dantrolene may be formulated as a pro-drug, a pro-pro-drug and the like.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: March 31, 2015
    Assignee: Howard University
    Inventors: Harpal S. Mangat, Pradeep K. Karla
  • Patent number: 8993513
    Abstract: A molecular device including: at least one molecule of zinc cytochrome c; in which an electron or a hole is transferred within the at least one molecule of zinc cytochrome c bar utilizing transition of an electron between molecular orbitals of the at least one molecule of zinc cytochrome c. The molecular orbitals, for example, are a first molecular orbital localized in a first amino acid residue of the at least one molecule of zinc cytochrome c, and a second molecular orbital which is localized in a second amino acid residue of the at least one molecule of zinc cytochrome c and which has a maximum transition probability per unit time with respect to the first molecular orbital. In this case, the electron or the hole is transferred between the first amino acid residue and the second amino acid residue.
    Type: Grant
    Filed: June 25, 2008
    Date of Patent: March 31, 2015
    Assignee: Sony Corporation
    Inventors: Yuichi Tokita, Jusuke Shimura
  • Patent number: 8993514
    Abstract: Methods of using portions of the N-terminal domain of prion protein for binding hemin are disclosed. In a particular embodiment, a method comprises administering at least one isolated amino acid sequence comprising a peptide from the octarepeat region of PrPC to a solution containing hemin, wherein the isolated amino acid sequence is effective for forming one or more chemical bonds with hemin.
    Type: Grant
    Filed: July 8, 2013
    Date of Patent: March 31, 2015
    Assignee: Florida State University Research Foundation, Inc.
    Inventor: Ewa Bienkiewicz
  • Patent number: 8993515
    Abstract: Novel peptidomimetics comprising N-amino cyclic urea residues are disclosed. Use of such peptidomimetics for modulating the activity of CD36 or IL-1 receptor in a cell, and for treating CD36- or IL-1-related disease, disorder or condition is also described.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: March 31, 2015
    Assignees: Valorisation-Recherche, Limited Partnership, RSEM, Limited Partnership
    Inventors: William D. Lubell, Sylvain Chemtob, Huy Ong, Robert Hopewell, Caroline Proulx, Kim Beauregard, Yesica Garcia-Ramos, Ngoc-Duc Doan
  • Patent number: 8993516
    Abstract: A method treating a patient includes administering a physiologically effective amount of a fibrillation-resistant insulin analogue or a physiologically acceptable salt thereof to the patient. The fibrillation-resistant insulin analogue or a physiologically acceptable salt thereof, contains an insulin A-chain sequence modified at position A8 and an insulin B-chain sequence or an analogue thereof. The fibrillation-resistant insulin analogue may exhibit thermodynamic stability similar to or exceeding that of wild-type human insulin and displays a susceptibility to fibrillation similar to or exceeding that of wild-type human insulin. An insulin analogue may display greater in vitro insulin receptor binding than normal insulin while displaying binding to IGFR less than twice that of normal insulin and less than that of fast-acting insulin analogs.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: March 31, 2015
    Assignee: Case Western Reserve University
    Inventor: Michael Weiss
  • Patent number: 8993517
    Abstract: The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
    Type: Grant
    Filed: June 27, 2013
    Date of Patent: March 31, 2015
    Assignee: Human Genome Sciences, Inc.
    Inventors: Craig A. Rosen, William A. Haseltine, Steven M. Ruben
  • Patent number: 8993518
    Abstract: The invention features compositions and methods of using a dimeric inhibitor, e.g., A1-A1, to selectively target ?2GPI in ?2GPI/antibody complexes. The compositions can be administered to subjects (e.g., a mammal, such as a human) having or likely to develop APS, or one or more symptoms of APS, in order to treat or inhibit the disease or treat or reduce its symptoms. The inhibitors of the invention include two ligand-binding A1 modules, e.g., from ApoER2, connected by a flexible linker.
    Type: Grant
    Filed: October 31, 2011
    Date of Patent: March 31, 2015
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventor: Natalia Beglova
  • Patent number: 8993519
    Abstract: Described herein are compositions and methods for treating, preventing and ameliorating diseases and conditions characterized by a lower than normal white blood cell count, such as leukopenia and neutropenia. The compositions and methods include recombinant human albumin-human granulocyte colony stimulating factor. Pharmaceutical formulations including the recombinant fusion protein, and methods of making such formulations are also described.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: March 31, 2015
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Jason Benjamin Bock, Xia Luo
  • Patent number: 8993520
    Abstract: The invention is directed to a transdermal drug delivery composition which includes at least one physiologically active agent; and at least one volatile solvent; and at least one viscosity modulating agent. The invention extends to methods of administering such a composition to a subject and treatment of subjects using the composition.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: March 31, 2015
    Assignee: Acrux DDS Pty Ltd
    Inventors: Tony Dipietro, Andrew Humberstone, Igor Gonda, Adam Watkinson, Kerrie Setiawan, Nina Wilkins
  • Patent number: 8993521
    Abstract: The present invention relates to a liquid oral pharmaceutical composition of desmopressin, and its use for the treatment of central diabetes insipidus, primary nocturnal enuresis, bleeding in patients with Hemophilia A, with von Willebrand-Jürgens disease and postoperative bleeding.
    Type: Grant
    Filed: August 1, 2008
    Date of Patent: March 31, 2015
    Assignees: GP Pharm, S.A., Laboratorio Reig Jofre, S.A.
    Inventors: Nuria Carbajal Navarro, Antonio Boix Montanes, Carlos Nieto Abad, Antonio Parente Duena, Ricard Mis Vizcaino, Cesar Garcia Plumed
  • Patent number: 8993522
    Abstract: The subject invention provides therapeutic compositions, and uses thereof for the treatment or amelioration of injury to small intestine mucosa. In preferred embodiments, the composition comprises one or more nutrients and/or electrolytes that acquire or retain considerable absorptive capacity.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: March 31, 2015
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Sadasivan Vidyasagar, Paul Okunieff, Lurong Zhang
  • Patent number: 8993523
    Abstract: The present invention provides compounds of formula M-L-M? (where M and M? are each independently a monomeric moiety of Formula (I) and L is a linker). The dimeric compounds have been found to be effective in promoting apoptosis in rapidly dividing cells.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: March 31, 2015
    Assignee: Novartis AG
    Inventors: Zhuoliang Chen, Christopher Sean Straub
  • Patent number: 8993524
    Abstract: The present invention is based on the seminal discovery that targeted immunomodulatory antibodies and fusion proteins can counter act or reverse immune tolerance of cancer cells. Cancer cells are able to escape elimination by chemotherapeutic agents or tumor-targeted antibodies via specific immunosuppressive mechanisms in the tumor microenvironment and such ability of cancer cells is recognized as immune tolerance. Such immune suppressive mechanisms include immunosuppressive cytokines (for example, Transforming growth factor beta (TGF-?) and regulatory T cells and/or immunosuppressive myeloid dendritic cells (DCs). By counteracting tumor-induced immune tolerance, the present invention provides effective compositions and methods for cancer treatment, optional in combination with another existing cancer treatment.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: March 31, 2015
    Assignee: The Johns Hopkins University
    Inventors: Atul Bedi, Rajani Ravi
  • Patent number: 8993525
    Abstract: Pharmacological chaperone compounds and methods for the treatment of an individual having, or at risk of having, a disease condition associated with alpha-1-antitrypsin by using said compounds are disclosed. In particular, such methods are useful for the treatment or prevention of lung disorders associated with alpha-1-antitrypsin deficiency as well as liver disorders associated with an excess of alpha-1-antitrypsin. Suitable pharmacological chaperones include peptides and low-molecular weight compounds. Also provided is an assay for determining whether a test compound modulates alpha-1-antitrypsin activity.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: March 31, 2015
    Assignee: Amicus Therapeutics, Inc.
    Inventors: Eric Richard Sjoberg, Gary Lee
  • Patent number: 8993526
    Abstract: The invention relates to the identification of carboxylic acids, present in human sweat, as natural ligands of a specific subgroup of seven olfactory receptor (OR) belonging to class 1 within the OR classification. The invention encompasses the use of the interaction of OR polypeptides and carboxylic acids as the basis of screening assays for agents that specifically modulate the activity of the seven ORs of the invention.
    Type: Grant
    Filed: June 12, 2013
    Date of Patent: March 31, 2015
    Assignee: ChemCom S.A.
    Inventors: Pierre Chatelain, Alex Veithen