Abstract: LXR nuclear receptor agonists have been previously shown to increase cholesterol efflux, raise plasma HDL cholesterol, stimulate cholesterol excretion, and reduce atherosclerotic lesions. However, these agonists have also been associated with the unwanted side effect of hypertriglyeridemia. This hypertriglyeridemia appears to be mediated by the LXR? subtype rather than LXR?, which suggests that LXR?-selective agonists are attractive candidates for modulation of human lipid metabolism. The present application provides novel LXR?-selective ligands that preferably modulate LXR? over LXR?. These ligands may be used to treat a variety of diseases associated with LXR, such as for example lipid metabolism disorders, atherosclerosis, Alzheimer disease, and inflammation.

Abstract: The invention relates to a viscoelastic system for drift reduction for pesticidal formulations, and the use thereof, wherein said formulation comprising at least one nitrogen-based cationic surfactant and at least one pesticide, wherein said pesticide contains at least one acid functional group associating with said cationic surfactant thereby forming a viscoelastic formulation.

Abstract: The present invention relates to substituted sulphonamido phenoxybenzamide compounds of general formula (I): in which A, R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined in the claims, to pharmaceutical compositions and combinations containing said compounds, to methods of preparing said compounds, and to the use of said compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.

Abstract: The present invention provides the use of a neutral endopeptidase inhibitor, in the manufacture of a medicament for the treatment, amelioration and/or prevention of contrast-induced nephropathy. The invention also relates to the use of a compound of Formula I: wherein R1, R2, R3, R5, X, A3, B1, s and n are defined herein, for the treatment, amelioration and/or prevention of contrast-induced nephropathy. The present invention further provides a combination of pharmacologically active agents for use in the treatment, amelioration and/or prevention of contrast-induced nephropathy.

Abstract: The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.

Abstract: It is reported herein that certain muscle diseases and conditions, including forms of muscular dystrophy, are characterized by impaired insulin-dependent signaling in the muscle tissue, in essence, a form of insulin resistance. The present disclosure relates to therapeutic agents, compositions and methods for treating a muscle disease or condition characterized by impaired insulin-dependent signaling by targeting components of the defective insulin signaling pathway. The disease or condition may be treated by administering a therapeutic agent that activates the insulin signaling pathway, in particular, therapeutic agents that act post-insulin receptor to modulate intracellular effector molecules. An exemplary modulator is metformin. Metformin may be administered alone or may be coadministered with another therapeutic agent for treating the muscle disease or condition, such as a corticosteroid.

Abstract: This application describes pharmaceutical compositions, kits, and methods for inhibiting cell proliferative disorders, especially those disorders characterized by overactivity and/or inappropriate activity of a receptor tyrosine kinase, including Her2 related cancers, and methods for imaging an Her-2 expressing tumor.

Abstract: The present invention relates to methods and feed compositions for increasing or maintaining the reproductive performance of sows. More particularly, the present invention relates to methods of increasing or maintaining the reproductive performance of sows by administering a biologically active compound during lactation, and food compositions comprising said biologically active compound for the purposes of increasing or maintaining the reproductive performance of sows. The present invention also relates to a method of increasing or maintaining ovarian function in sows.

Abstract: Ophthalmic, otic and nasal compositions containing a new class of antibiotics (e.g., moxifloxacin) are disclosed. The compositions preferably also contain one or more anti-inflammatory agents. The compositions may be utilized to treat ophthalmic, otic and nasal conditions by topically applying the compositions to the affected tissues.

Abstract: The present invention relates to a new use of citral for manufacturing a medicament for treating focal segmental glomerulosclerosis (FSGS). Particularly, the present invention discloses that citral is effective in alleviating symptoms of FSGS, including reducing glomerular epithelial hyperplasia lesions (EPHLs), peri-glomerular inflammation or glomerular hyalinosis or sclerosis, and also reducing proteinuria or hematuria or lowering serum urea nitrogen level or serum creatinine level in the subject.

Abstract: Provided are biocidal compositions comprising: tris(hydroxymethyl)nitromethane; and a brominated nitroalkanol compound of formula I: wherein R1, R2, and R3 are as defined herein. The compositions are useful for controlling microorganisms in aqueous or water-containing systems.

Abstract: The invention relates to the use of a L-theanine for the treatment of gastroesophageal reflux disease (e.g., heartburn) in a human or animal, including useful methods and compositions.

Abstract: The present invention relates generally to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide, polymorphic forms thereof, methods for preparation and use thereof, pharmaceutical compositions thereof, and kits and articles of manufacture thereof.

Abstract: A composition for and methods of preserving a topical cosmetic, toiletry or pharmaceutical formulation against microbiological contamination or growth are described in which the compositions used herein include at least one hydroxamic acid, salt or complex thereof, and the methods include addition of an effective amount of such compounds to a cosmetic, toiletry or pharmaceutical formulation. Compositions further including alkanediols and/or solubilizing agents in blends with hydroxamic acid are also described.

Abstract: The present invention provides a process for producing a hydrocarbon oil by performing a Fischer-Tropsch synthesis reaction using a reactor for a Fischer-Tropsch synthesis including a reaction apparatus having a slurry containing catalyst particles and a gaseous phase located above the slurry to obtain a hydrocarbon oil, wherein the Fischer-Tropsch reaction is performed while controlling a temperature of the slurry so that a difference T2?T1 between the average temperature T1 of the slurry and a temperature T2 at the liquid level of the slurry in contact with the gaseous phase is 5 to 30° C.

Abstract: Methods for producing or regenerating an iodinated anion exchange resin are presented. The methods include treating an iodide loaded anionic resin with an aqueous solution comprising an in situ formed I2 to produce the iodinated resin. The iodinated resins show reduced and stable levels of iodine elution compared to resins produced by conventional methods. Methods and systems for purifying water are also presented.

Abstract: Methods of reclaiming plastic from plastic medical waste containers containing medical waste and manufacturing recycled medical devices are described. Recycled medical devices made from plastic medical waste containers containing medical waste are also described.

Abstract: Provided by the invention is a compound containing an imido group that is obtained by partial hydrolysis of a polyimide molded article, in which the compound has an absorption peak derived from an imido group at wave number of 1375 cm?1, an absorption peak derived from an amide group at wave number of 1600 cm?1, and an absorption peak derived from a carboxyl group at wave number of 1413 cm?1 in the IR spectrum chart obtained by IR spectroscopic measurement.

Abstract: A porous polymer separator for use in a lithium ion battery is formed by a temperature-induced phase separation method. The porous polymer separator includes a polymer matrix having opposed major faces and a network of pore openings that extends between the major faces and permits intrusion of a lithium-ion conducting electrolyte solution. As part of the temperature-induced phase separation method, a single phase polymer solution that includes a polymer material dissolved in a miscible mixture of a real polymer solvent and a polymer non-solvent is prepared at an elevated temperature above room temperature. A film is then formed from the single phase polymer solution and cooled to phase-separate the polymer material into a solid polymer precipitate. Additional polymer non-solvent is then used to remove the real polymer solvent from the solid polymer precipitate followed by drying.

Abstract: [Objects] It is an object to provide a foam having a low specific gravity and a small compression set, more preferably a foam having a low specific gravity, a small compression set and uniform quality, a foaming composition, and applications of the foam. [Means for Solution] The foam is obtained by foaming an olefin polymer, wherein the foam has a specific gravity (d) in the range of 0.03 to 0.30, and a compression set (CS, %) and the specific gravity (d) satisfy the formula of CS??279×(d)+95. The foam is preferably obtained from a foaming composition that includes an ethylene polymer (A) including a specific ethylene/?-olefin copolymer (A1) and an ethylene/polar monomer copolymer (A2) in a specific mass ratio, and a specific ethylene/C3-20 ?-olefin/non-conjugated polyene copolymer (B).

Abstract: A polishing pad capable of maintaining a high level of dimensional stability during absorption of moisture or water includes a polishing layer including a polyurethane foam having fine cells, wherein the polyurethane foam includes a cured product of a reaction of an isocyanate-terminated prepolymer (A), a polymerized diisocyanate, and a chain extender, and the isocyanate-terminated prepolymer (A) includes an isocyanate monomer, a high molecular weight polyol (a), and a low molecular weight polyol. A method for manufacturing such a polishing pad includes mixing a first component containing an isocyanate-terminated prepolymer with a second component containing a chain extender and curing the mixture to form a polyurethane foam. The pad so made is used in the manufacture of semiconductor devices.

Abstract: Provided is a pressure-sensitive adhesive for polarizing plates which can adhere a polarizing plate on a liquid crystal cell with good adhesion durability and has the characteristic that a liquid crystal display device obtained therefrom is less liable to cause light leakage even under the environment of high temperature and high humidity and which makes it possible remove the polarizing plate.

Abstract: A dental coloring material composition comprising containing: (a) a polymerizable monomer and/or an oligomer, (b) a polymerization catalyst, and (c) a pigment and/or a dye, wherein a color tone thereof is a cyan color based on three subtractive primary colors, or a color tone thereof is a magenta color based on three subtractive primary colors, or a color tone thereof is a yellow color based on three subtractive primary colors, and a dental color material set using the dental coloring material compositions in combination.

Abstract: The invention provide a class of chain-extended polysiloxane crosslinkers which comprises (1) at least two polysiloxane segments, wherein each pair of adjacent polysiloxane segments is linked by one divalent organic radical which includes at least one pendant hydrophilic group (hydroxyl and/or carboxyl groups) or at least one dangling hydrophilic polymer chain and a di-thioether linkage —S-DR-S— in which DR is a divalent organic radical; and (2) two terminal ethylenically unsaturated groups. The present invention is also related to a polymer comprising crosslinking units derived from chain-extended polysiloxane crosslinker of the invention and to ophthalmic lenses comprising such a polymer.

Abstract: A dual-cure curable material kit comprising: (A) a radical-polymerizable monomer component; (B) a photopolymerization initiator component comprising (b1) an ?-diketone compound, (b2) an aliphatic tertiary amine compound having a tertiary amino group in which three saturated aliphatic groups are bonded to a nitrogen atom and one of the saturated aliphatic groups has an electron-withdrawing group as a substituent, and (b3) an s-triazine compound having a trihalomethyl group as a substituent, or a diaryliodonium salt compound; and a chemical polymerization initiator component (C) comprising (c1) an organic peroxide, and (c2) an N,N-di(hydroxyalkyl)-p-toluidine compound; which is packed separately at least in two packages so that the component (b2) and the component (b3) of the photopolymerization initiator component (B) are not packed together in a single package and the component (c1) and the component (c2) of the chemical polymerization initiator component (C) are not packed together in a single package.

Abstract: The present invention relates to biodegradable polymers, and especially polyacrylic and/or polyaspartic acid based biodegradable polymers. Further, the present invention relates to methods for the preparation of the present biodegradable polymers and the use thereof as, for example, protective layer or packaging material. Specifically, the present invention relates to methods for preparing a biodegradable polymer comprising: a) preparing an acidic mixture of polyacrylic and/or polyaspartic acid, sodium ions, one or more oligosaccharides, or derivatives thereof, and water, wherein the resulting mixture has a pH equal to or lower than 5; b) maintaining the temperature of said acidic mixture in a range of from 80° C. to 130° C. until an homogeneous suspension is obtained; and c) adding polyvinyl alcohol (PVA) and one or more polycarboxylic acids, or derivatives thereof, to the mixture of step (b) while maintaining the temperature in a range of from 80° C. to 130° C. until the biodegradable polymer is formed.

Abstract: The invention relates to a graft copolymer latex comprising the which comprises a graft copolymer ABC of at least one olefinically unsaturated monomer C and at least one modified alkyd resin A2B or modified oil A1B which modified alkyd resin A2B or modified oil A1B have chain-pendant olefinically unsaturated groups, to a process for its preparation, and the use thereof a binder in coating compositions.

Abstract: Capable of being provided are [1] a master batch comprising polyamide (X) comprising a diamine unit containing 70 mole % or more of a metaxylylenediamine unit and a dicarboxylic acid unit and an alkali compound (A), wherein an average particle diameter of the alkali compound (A) contained in the master batch is 50 ?m or less; a contained number of particles having a particle diameter of exceeding 80 ?m in 5 square millimeter of a cross section of the master batch is 1.5 particle or less; and a sum (m) of values obtained by multiplying a mole concentration of an alkali metal atom and a mole concentration of an alkaline earth metal atom each contained per g of the master batch by valencies thereof respectively is 60 ?mol/g or more and 1710 ?mol/g or less and [2] a production process for a polyamide resin composition prepared by making use of the master batch described in the above item [1].

Abstract: The present invention discloses compositions and methods wherein polycarboxylate comb polymers are used as grinding additives. The comb polymers contain a carbon-containing backbone and pendant groups wherein oxyalkylene pendant groups contain one or more ether linkage groups for providing robustness to the polymer for resisting degradation during grinding and hence sustaining workability and strength of hydratable cementitious materials, such as cements, pozzolans, limestone, and other cementitious materials.

Abstract: An acid modified asphalt binder is combined with an emulsifier solution to produce an emulsified asphalt binder. The acid modified asphalt binder may be formed by combining an asphalt binder, a phosphorous-based acid, and, optionally, a polymer modifier. The emulsifier solution may be produced by forming an aqueous solution of an amine and a phosphorous-based acid, which forms an aqueous solution comprising an amine phosphate. The emulsified asphalt binder may be combined with an aggregate to form a paving material. In other examples, the emulsified asphalt binder may be used alone, for example in a chip seal application, or in a diluted form, for example in a fog seal application.

Abstract: A surfactant composition selected from the group consisting of: ArO—(CH2CH[CH2CH3]O)1-10(CH2CH2O)5-50H, isomers, aromatic ring substituted analogs, and mixtures thereof; and an aqueous coating composition including an aqueous polymeric dispersion, and certain other compositions, including the surfactant composition are provided. Also provided are a method for forming a coating and a method for improving the freeze/thaw stability of an aqueous composition including an aqueous polymeric dispersion.

Abstract: A rubber composition contains diene-based rubber, silica, a sulfur-containing silane coupling agent, and an amine compound. The amine compound is indole, indigo, and derivatives thereof each of which is represented by a predetermined formula. The content of the silica is 20 to 120 parts by mass based on 100 parts by mass of the diene-based rubber. The content of the sulfur-containing silane coupling agent is 3 to 15 parts by mass based on 100 parts by mass of the silica. The content of the amine compound is 0.5 to 20 parts by mass based on 100 parts by mass of the silica. By the use of the rubber composition with this composition, a tire having improved dispersibility of silica, excellent wet performance, and excellent rolling resistance and showing a suppressed decrease in reinforcing property can be produced.

Abstract: The instant invention pertains to the use of an antistatic composition comprising a polar thermoplastic polymer and an ionic liquid as antistatic additive for non-polar thermo-plastic or elastomeric polymers. Further aspects of the invention are a process for the preparation of an antistatic non-polar thermoplastic or elastomeric polymer which process comprises incorporating therein a mixture of a polar thermoplastic polymer and an ionic liquid and the composition of a polar thermoplastic polymer, an ionic liquid and a non-polar thermoplastic or elastomeric polymer.

Abstract: Provided is a chloroprene rubber superior in the effectiveness of preventing mold staining. The chloroprene rubber contains at least one compound selected from phosphite ester compounds (such as tris(nonylphenyl)phosphite ester and tributyl phosphite ester) and phosphate ester compounds (such as tri(nonylphenyl)phosphate ester and tributyl phosphate ester) in a total amount of 0.1 to 5.0 mass % and additionally at least one compound selected from sulfonic acid compounds (such as benzenesulfonic acid and dodecylbenzenesulfonic acid) and fatty acid compounds in a total amount of 0.1 to 3.0 mass %.

Abstract: The present invention relates to a pulverulent adhesive for textile reinforcing inserts, which is dispersible in water, for the production of reinforced rubber products. The adhesive thereby comprises an at least partially capped, low-molecular isocyanate, a wetting agent, a binder and also possibly further additives.

Abstract: An aerosol is described comprising a composition comprising an acrylic block copolymer, a solvent, and a propellant. An article is described comprising the aerosol contained within a pressurized containment vessel comprising a valve. An aerosol mist is also described comprising droplets of an adhesive composition, wherein the adhesive composition comprises an acrylic block copolymer, a glass transition temperature modifier, and optionally an additive.

Abstract: The present invention provides a rubber composition for tires capable of improving handling stability, fuel economy, wet grip performance, elongation at break, and abrasion resistance together while maintaining the balance between them. The present invention also provides a pneumatic tire including the rubber composition. The present invention relates to a rubber composition for tires containing a diene rubber, silica having a BET specific surface area of 170 to 270 m2/g, sulfur, and a liquid resin having a softening point of ?20 to 45° C., wherein the amount of the liquid resin is 0.5 to 20 parts by mass, and the amount of the silica is 40 to 120 parts by mass, each per 100 parts by mass of the rubber component of the rubber composition.

Abstract: The present invention relates to polymers, nanomaterials, and methods of making the same. Various embodiments provide an amphiphilic multi-arm copolymer. The copolymer includes a core unit and a plurality of amphiphilic block copolymer arms. Each block copolymer arm is substituted on the core unit. Each block copolymer arm includes at least one hydrophilic homopolymer subunit and at least one hydrophobic homopolymer subunit. In some examples, the copolymer can include a star-like or bottlebrush-like block copolymer, and can include a Janus copolymer. Various embodiments provide a nanomaterial. In some examples, the nanomaterial can include Janus nanomaterials, and can include nanoparticles, nanorods, or nanotubes. The nanomaterial includes the amphiphilic multi-arm copolymer and at least one inorganic precursor. The inorganic precursor can be coordinated to at least one homopolymer subunit of one of the amphiphilic block copolymer arms to form the nanomaterial.

Abstract: For the purpose of improving rolling resistance and durability, the present invention provides a rubber composition for insulation of a tire comprising 0.2 to 4 parts by mass of (B) an alkylphenol-sulfur chloride condensate, and 20 to 59 parts by mass of (C) carbon black having a BET specific surface area of 25 to 50 m2/g based on 100 parts by mass of (A) a rubber component comprising 30 to 85% by mass of (a1) a natural rubber and/or an isoprene rubber, 0 to 70% by mass of (a2) at least one styrene butadiene rubber selected from the group consisting of an emulsion-polymerized styrene butadiene rubber, a solution-polymerized styrene butadiene rubber and a modified styrene butadiene rubber, and 0 to 60% by mass of (a3) a butadiene rubber, and a tire having insulation prepared from the rubber composition.

Abstract: The present invention provides elastomeric roof coatings and aqueous coating compositions of (i) an acrylic emulsion copolymer that comprises (ii) a reductant and has a high molecular weight, (iii) a combination of a hydrophilic polymeric dispersant and a pigment, extender or filler, and (iv) a multivalent transition metal ion or multivalent transition metal ion compound or salt. The composition and coating provide excellent swelling resistance and a balance of tensile and elongation in an acrylic roof coating composition.

Abstract: What are described are polyvinyl ester dispersions which are prepared in a multistage process and have a low content of polymerized acids or acid anhydrides. They can be obtained by a multistage process in which a polyvinyl ester dispersion is obtained in a first stage, monomers in dissolved or pure form are added to the reaction mixture in a second stage and then the polymerization is started again. The polymer dispersions obtained in this way are notable for a low coagulum content and for increased tensile strengths of the films formed therefrom.

Abstract: The present invention is directed to a functionalized elastomer comprising the reaction product of a living anionic elastomeric polymer and a polymerization terminator of formula I wherein R1, R2, R3, R4, and R5 are as defined. The invention is further directed to a rubber composition including the functionalized elastomer, and a pneumatic tire including the rubber composition.

Abstract: The present invention provides a glass fiber-reinforced thermoplastic resin composition in which a particular relationship is satisfied between the glass fiber content (W (parts by weight)) and the melt viscosity (?) of the thermoplastic resin composition at molding temperature as determined at a shear rate of 1,000 sec?1. According to the present invention, there can be obtained a glass fiber-reinforced thermoplastic resin having increased strength and rigidity and excellent in practical characteristics such as impact resistance and antifreeze liquid resistance. In addition, molded articles obtained by injection-molding the composition are available as components having reduced anisotropies of mechanical characteristics and mold shrinkage factor.

Abstract: The present invention is directed to a blended composition comprising one or more polycarbonates wherein at least one of the polycarbonates is a polyesterpolycarbonate having at least one unit derived from a soft block ester unit, e.g., sebacic acid, and at least one unit derived from bisphenol A, and a polylactic polymer wherein the composition has an overall biocontent of at least 10% according to ASTMD6866.

Abstract: Polyolefin block and graft copolymers comprised of two or more semicrystalline polyolefin blocks or grafts and one or more amorphous polyolefin blocks can be blended with a low molecular weight fluid diluent that preferentially locates within and swells the amorphous domains of the block or graft copolymer, while preserving the crystallinity of the semicrystalline block domains. After mechanical or thermomechanical processing, such compositions combine softness with high strength and high recoverable elasticity. Compositions are also disclosed whereby the diluent species is removed from the composition, either before or after the mechanical or thermomechanical processing, in order to create a strong elastic material with an ultra-low entanglement density within the amorphous domains.

Abstract: An object of the present invention is to provide an aqueous coating composition with excellent finished appearance and removability in bell cleaning, and a method for forming a multilayer coating film having excellent smoothness by a 3-coat-1-bake method including successively applying an aqueous first colored coating composition, an aqueous second colored coating composition, and a clear coating composition to a substrate, and heat-curing the resulting three layers of the multilayer coating film all at once.

Abstract: To provide an inkjet ink polymer capable of providing an inkjet ink capable of forming a printed product having excellent weather resistance, print density (coloring properties), and fixability (abrasion properties) with good productivity and providing a pigment dispersion having excellent dispersibility with good productivity. An inkjet ink copolymer contains 10 to 99% by weight of a cyclohexyl methacrylate unit and 1 to 90% by weight of an acrylic acid unit. The purpose is achieved by an inkjet ink pigment dispersion containing the inkjet ink copolymer and a pigment.

Abstract: An alkali metal-reacted aromatic compound which has three or more carbon atoms which are directly bonded to alkali metal atoms and aromatic rings in one molecule is used as a polymerization initiator to polymerize a monomer mixture which is contains at least one conjugated diene compound to thereby produce a radial conjugated diene polymer. Further, active ends of the polymer having active ends which is obtained by this method is made to react with a modifier which can react with the active ends to thereby produce an end-modified radial conjugated diene polymer. According to the present invention, it is possible to provide a method of production of the radial conjugated diene polymer which gives a high degree of freedom of polymer design and easy control of the polymer structure.

Abstract: A blend of polylactic acid resin and copolyester resin, which has excellent impact resistance and heat resistance, and a molded article manufactured using the same are disclosed. The blend of polylactic acid resin and copolyester resin, comprises 5 to 94 wt % of a polylactic acid resin; 3 to 92 wt % of a copolyester resin comprising a dicarboxylic acid component, which contains a terephthalic acid residue, and a diol component which contains 3 to 99 mol % of a cyclohexanedimethanol residue and 1 to 60 mol % of an isosorbide residue; and 3-30 wt % of a compatibilizer containing at least one reactive functional group selected from the group consisting of glycidyl, maleic anhydride, epoxy, isocyanate, amino, carboxylic acid and oxazoline groups, and mixtures thereof.

Abstract: Provided is a polyamide resin composition comprising an elastomer etc, and a reactive polyamide resin excellent in reactivity. The polyamide resin composition comprises 0.5 to 100 parts by mass of an elastomer per 100 parts by mass of a reactive polyamide resin, wherein the reactive polyamide resin obtained by polycondensing a diamine (A) containing 70 mol % or more of a diamine structural unit derived from xylylenediamine and a dicarboxylic acid (B) containing 50 mol % or more of a dicarboxylic acid structural unit derived from sebacic acid, and has a concentration of reactive functional groups of 100 ?eq/g or more and a molar ratio of reacted diamine to reacted dicarboxylic acid (the number of moles of reacted diamine/the number of moles of reacted dicarboxylic acid) of 1.0 or more.