Patents Issued in April 14, 2015
  • Patent number: 9005951
    Abstract: A method for studying a biological sample in a biochip (“lab-on-a-chip”) is disclosed. In at least one embodiment of the method, a biological sample is introduced into the biochip, the sample is subjected to at least one preparation step and, at the end of a measurement cycle, the concentration of a particular analyte is measured. The concentration of a marker substance, which for example is a reaction substance involved in a preparation step, is furthermore measured. A corresponding biochip is further disclosed.
    Type: Grant
    Filed: December 12, 2006
    Date of Patent: April 14, 2015
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventor: Klaus Abraham-Fuchs
  • Patent number: 9005952
    Abstract: The present invention relates to a microorganism producing L-methionine precursor, O-acetylhomoserine, and a method of producing L-methionine precursor using the microorganism.
    Type: Grant
    Filed: April 4, 2008
    Date of Patent: April 14, 2015
    Assignee: CJ Cheiljedang Corporation
    Inventors: Chul Ha Kim, So Young Kim, Young Uk Shin, Hye Won Um, Jin Sook Chang, Young Wook Cho, Han Jin Lee, In Kyung Heo, Chang Il Seo, Kwang Ho Na
  • Patent number: 9005953
    Abstract: This invention relates to a recombinant microorganism having improved butanol production capacity and butanol production with the use of such recombinant microorganism with good efficiency. In this invention, the acetoacetyl-CoA synthase gene encoding an enzyme capable of synthesizing acetoacetyl-CoA from malonyl-CoA and acetyl-CoA and a group of genes involved in butanol biosynthesis that enables synthesis of butanol from acetoacetyl-CoA are introduced into a host microorganism.
    Type: Grant
    Filed: May 6, 2010
    Date of Patent: April 14, 2015
    Assignee: Toyota Jidosha Kabushiki Kaisha
    Inventors: Masayoshi Muramatsu, Shusei Obata, Satoshi Yoneda, Masahiro Sugimura, Tomohisa Kuzuyama
  • Patent number: 9005954
    Abstract: The present invention relates to compositions and methods to identify novel bacteria and metabolites derived therefrom. More specifically, the invention describes a novel method to isolate bacteria producing metabolites of interest from environmental samples. Particularly, the invention discloses a method to select rare antibiotic producing bacteria. The invention can be used from any sample and allows the isolation of bacteria having e.g., pharmaceutical or agrochemical interest.
    Type: Grant
    Filed: January 18, 2010
    Date of Patent: April 14, 2015
    Assignees: Deinove, Centre National de la Recherche Scientifique
    Inventors: Jean-Paul Leonetti, Stéphanie Texier
  • Patent number: 9005955
    Abstract: Cultures of Chlamydomonas are disclosed comprising greater than 340 mg/l triacylglycerols (TAG). The cultures can include buoyant Chlamydomonas. Methods of forming the cultures are also disclosed. In some embodiments, these methods comprise providing Chlamydomonas growing in log phase in a first culture medium comprising a nitrogen source and acetate, replacing the first culture medium with a second medium comprising acetate but no nitrogen source, and subsequently supplementing the second medium with additional acetate. In some embodiments, a culture can comprise at least 1,300 mg/l triacyglycerols. In some embodiments, cultures can be used to produce a biofuel such as biodiesel.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: April 14, 2015
    Assignee: Washington University
    Inventors: Ursula Goodenough, Carrie Goodson
  • Patent number: 9005956
    Abstract: The present invention relates to a method of selectively obtaining phosphorus from solids containing heavy metals and phosphate. In this method, the solid is treated under acidic aerobic conditions using microorganisms comprising leaching microorganisms and polyphosphate-accumulating microorganisms, so that the heavy metals and the phosphates are released from the solid and the released phosphates may be taken up by the polyphosphate-accumulating microorganisms. The phosphorus-enriched biomass that is obtained in this manner is separated and may be utilized, e.g., as organic fertilizer.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: April 14, 2015
    Assignee: Georg Fritzmeier GmbH & Co. KG
    Inventors: Jennifer Zimmermann, Wolfgang Dott
  • Patent number: 9005957
    Abstract: The present invention relates to a microorganism of the Corynebacterium genus that produces N-acetyl glucosamine which retains the activity of 6-phophate acetyltransferase and a method for producing N-acetyl glucosamine or glucosamine using the same.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: April 14, 2015
    Assignee: CJ Cheiljedang Corporation
    Inventors: Kuk-Ki Hong, Jin-Su Chung, Sooan Shin, Hyeran Park, Jaehyun Jo
  • Patent number: 9005958
    Abstract: A cultivation apparatus and a cultivation method of a culture such as a cell or tissue. Provided are an incubator unit for accommodating a culture and a lever that penetrates through the incubator unit and can move in circular arc around a fulcrum as a center, the fulcrum being set at a wall of the incubator unit or in the vicinity thereof, then displacement is imparted to the culture by operating the lever. Bending force can be acted on the culture (cell construct) such as a cell or tissue, so that without any increase or decrease of a culture fluid in the incubator unit, namely, without any increase or decrease of pressure to the culture fluid, displacement required for cultivation can be imparted to the culture in the incubator unit. By curving, continuous compression and extension are generated in a direction of thickness from a concave portion to a convex portion of the curving.
    Type: Grant
    Filed: June 20, 2007
    Date of Patent: April 14, 2015
    Assignee: Purpose Company Limited
    Inventor: Setsuo Watanabe
  • Patent number: 9005959
    Abstract: An exhaust system suitable for high volume exhaust from flexible disposable bags is described that prevents nutrient media volume loss and prevents cross-contamination without using any filters. The invention described here allows the use of disposable two-dimensional bioreactors for the cultivation of bacterial and other organisms and cells require high aeration.
    Type: Grant
    Filed: May 1, 2011
    Date of Patent: April 14, 2015
    Assignee: Therapeutic Proteins International, LLC
    Inventor: Sarfaraz Niazi
  • Patent number: 9005960
    Abstract: The present invention relates to a functionalized semi-permeable membrane composed of a porous biocompatible support pretreated so as to increase the surface energy thereof and characterized in that it includes at least two layers, each having a hydrophilic polymer and at least one biological active molecule, and to the use thereof in particular for producing a bioartificial organ.
    Type: Grant
    Filed: May 31, 2011
    Date of Patent: April 14, 2015
    Assignees: Association pour les Transferts de Technologie du Mans, Centre Europeen d'Etude du Diabete
    Inventors: Gilbert Legeay, Séverine Sigrist, Arnaud Coudreuse
  • Patent number: 9005961
    Abstract: The invention relates to a cDNA molecule which encodes the nucleotide sequence of the full length antigenomic (+)RNA strand of a measles virus (MV) originating from an approved vaccine strain, for example, the Schwarz strain. It also concerns the preparation of infectious recombinant viruses and immunogenic compositions using the cDNA.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: April 14, 2015
    Assignees: Institut Pasteur, Centre National de la Recherche Scientifique
    Inventors: Fréderic Tangy, Chantal Combredet, Valérie Labrousse-Najburg, Michel Brahic
  • Patent number: 9005962
    Abstract: The present invention relates to the generation of anterior definitive endoderm (ADE) cells from embryonic stem cells and the differentiation of such cells to, for example, pancreatic or liver cells. The invention also relates to cell lines, cell culture methods, cells markers and the like and their potential uses in a variety of applications.
    Type: Grant
    Filed: August 25, 2008
    Date of Patent: April 14, 2015
    Assignee: The University Court of the University of Edinburgh
    Inventors: Gillian Mary Morrison, Joshua Mark Brickman, Ifigenia Oikonomopoulou
  • Patent number: 9005963
    Abstract: The present invention relates to amino acid sequences that are directed against (as defined herein) human cellular receptors for viruses and/or bacteria such as e.g. NANOBODIES specifically recognizing hCD4, hCXCR4, hCCR5, hTLR4, human alphaV integrin, human beta3 integrin, human beta1 integrin, human alpha2 integrin, hCD81, hSR-BI, hClaudin-1, hClaudin-6 and hClaudin-9, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The amino acid sequences may be used to prevent human cell entry of HIV, HCV, adenoviruses, hantavirus, herpesvirus, echo-virus 1 and others.
    Type: Grant
    Filed: October 14, 2009
    Date of Patent: April 14, 2015
    Assignee: Ablynx N.V.
    Inventors: Christophe Blanchetot, Martine Smit, Regorius Leurs, Sven Jähnichen, Dominique Schols, Michael John Scott Saunders, Johannes Joseph Wilhelmus De Haard, Peter Vanlandschoot, Peter Verheesen
  • Patent number: 9005964
    Abstract: The present invention relates to endodermal progenitor cells and methods of isolation, culture, differentiation and use thereof.
    Type: Grant
    Filed: November 26, 2007
    Date of Patent: April 14, 2015
    Assignee: Regents of the University of Minnesota
    Inventors: Catherine Verfaillie, Lucas Chase
  • Patent number: 9005965
    Abstract: Provided are systems and methods for providing human cell cultures. Further provided are cultures of feeder cells for use in stem cell technology, as well as cultures, culture systems and methods for maintenance and propagating of stem cells in an undifferentiated state as well as for the development of somatic cells cultures from stem cells, the somatic cell cultures being free of extraembryonic cells.
    Type: Grant
    Filed: January 13, 2011
    Date of Patent: April 14, 2015
    Assignee: Hadasit Medical Research Services & Development Limited
    Inventors: Etti Ben Shushan, Shelly Tannenbaum, Pavel Itsykson, Eyal Banin, Benjamin Reubinoff
  • Patent number: 9005966
    Abstract: Provided are methods and compositions useful for producing and propagating stem cells from fibroblasts.
    Type: Grant
    Filed: November 19, 2008
    Date of Patent: April 14, 2015
    Assignee: The Regents of the University of California
    Inventors: William E. Lowry, Kathrin Plath
  • Patent number: 9005967
    Abstract: The present invention provides a method for improving iPS cell generation efficiency, which comprises a step of introducing a Myc variant having the following features: (1) having an activity to improve iPS cell generation efficiency which is comparative to, or greater than that of c-Myc; and (2) having a transformation activity which is lower than that of c-Myc; or a nucleic acid encoding the variant, in a nuclear reprogramming step. Also, the present invention provides a method for preparing iPS cells, which comprises a step of introducing the above Myc variant or a nucleic acid encoding the variant and a combination of nuclear reprogramming factors into somatic cells. Moreover, the present invention provides iPS cells comprising the nucleic acid encoding the Myc variant which can be obtained by the above method, and a method for preparing somatic cells which comprises inducing differentiation of the iPS cells.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: April 14, 2015
    Assignee: Kyoto University
    Inventors: Shinya Yamanaka, Masato Nakagawa
  • Patent number: 9005968
    Abstract: The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, non-viral methods for reprogramming human somatic cells.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: April 14, 2015
    Assignee: The Scripps Research Institute
    Inventors: Tongxiang Lin, Sheng Ding
  • Patent number: 9005969
    Abstract: In one embodiment, a monocyte derived bone-forming cell population is provided. In one embodiment, the cell population comprises an isolated monocyte cell population treated with an effective dose of LL-37. In another embodiment, a method of producing a population of monocyte-derived bone-forming cells is provided. The method comprises obtaining a blood sample from a subject; isolating a population of monocytes from the blood sample; treating the isolated monocytes with an effective dose of LL-37; and culturing the LL-37 treated monocytes until they differentiate into the population of monocyte-derived bone-forming cells. In another embodiment, a method of treatment for a bone injury or bone disease is provided. The method comprises administering a therapeutically effective amount of a composition to a subject having the bone injury or disease, the composition comprising a population of monoosteophils.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: April 14, 2015
    Assignee: City of Hope
    Inventors: Zhifang Zhang, John E. Shively
  • Patent number: 9005970
    Abstract: [PROBLEMS] Relating to a bioassay method with the use of cultured cells and cell culture for a therapeutic purpose in the case of determining the efficacy of a drug or the like or examining the toxicity thereof, it is intended to provide a method of culturing cells under regulation in the extension direction and a cell culture plate. [MEANS FOR SOLVING PROBLEMS] A cell culture plate having a plural number of side walls (1) and a plural number of space structures (3) for providing cultured cells which are formed by the side walls (1), wherein the side walls (1) are provided with openings (2) so that the space structures (3) are linked together. By using this cell culture plate, a method of culturing cells under regulation in the extension direction can be provided.
    Type: Grant
    Filed: January 11, 2006
    Date of Patent: April 14, 2015
    Assignees: Kuraray Co., Ltd., Ryosuke Nishio
    Inventors: Ryosuke Nishio, Taiji Nishi, Motohiro Fukuda, Yasuzo Kirita, Seiichi Kanai, Takenori Kitani
  • Patent number: 9005971
    Abstract: A container system includes a bag having of one or more sheets of flexible polymeric material, the bag having an interior surface at least partially bounding a chamber that is adapted to hold a fluid. A sparger is secured to the interior surface of the bag so that a compartment is formed between the interior surface of the bag and the sparger. At least a portion of the sparger includes a sparging sheet formed from a flexible sheet of a gas permeable material. A tubular port or tube is coupled with the bag so that a passage bounded by the tubular port or tube communicates with the compartment.
    Type: Grant
    Filed: December 2, 2013
    Date of Patent: April 14, 2015
    Assignee: Life Technologies Corporation
    Inventors: Michael E. Goodwin, Nephi D. Jones, Jeremy K. Larsen
  • Patent number: 9005972
    Abstract: Provided herein is an apparatus for printing cells which includes an electrospinning device and an inkjet printing device operatively associated therewith. Methods of making a biodegradable scaffold having cells seeded therein are also provided. Methods of forming microparticles containing one or more cells encapsulated by a substrate are also provided, as are methods of forming an array of said microparticles.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: April 14, 2015
    Assignee: Wake Forest University Health Sciences
    Inventors: Tao Xu, James J. Yoo, Anthony Atala, Dennis Dice
  • Patent number: 9005973
    Abstract: Disclosed herein are donor molecules comprising single-stranded complementary regions flanking one or more sequences of interest. The donor molecules and/or compositions comprising these molecules can be used in methods for targeted integration of an exogenous sequence into a specified region of interest in the genome of a cell.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: April 14, 2015
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Gregory J. Cost, Dmitry M. Guschin, Fyodor Urnov
  • Patent number: 9005974
    Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.
    Type: Grant
    Filed: December 9, 2005
    Date of Patent: April 14, 2015
    Assignees: Academish Medisch Centrum Bij de Universiteit van Amsterdam, AIMM Therapeutics B.V.
    Inventor: Hergen Spits
  • Patent number: 9005975
    Abstract: To efficiently identify and select a clone from clones of induced pluripotent stem cells (iPS cell) having low tumor formation rate in vivo when allowed to differentiate and transplanted in a living body, iPS cells of the clones are induced to differentiate, undifferentiated cells among the cells after the induction of differentiation are detected, and a clone having the content of the undifferentiated cell below a control is selected.
    Type: Grant
    Filed: May 28, 2010
    Date of Patent: April 14, 2015
    Assignee: Kyoto University
    Inventors: Hideyuki Okano, Yohei Okada, Shinya Yamanaka, Kyoko Miura
  • Patent number: 9005976
    Abstract: The present invention relates to a method for selecting induced pluripotent stem (iPS) cells.
    Type: Grant
    Filed: September 1, 2010
    Date of Patent: April 14, 2015
    Assignee: Kyoto University
    Inventors: Shinya Yamanaka, Takayuki Tanaka
  • Patent number: 9005977
    Abstract: The invention provides methods and compositions for inhibiting proliferation of a modified host cell outside of a designated process condition. Compositions and methods for providing a host cell having reduced viability when exposed to natural conditions external to a controlled environment are disclosed.
    Type: Grant
    Filed: September 21, 2011
    Date of Patent: April 14, 2015
    Assignee: Joule Unlimited Technologies, Inc.
    Inventors: George Church, Frank A. Skraly, Brian D. Green, Jacob C. Harrison
  • Patent number: 9005978
    Abstract: A pouch (2) includes: a first, inner, envelope (1) which is closed, delimiting a first space (6) forming a pouch stricto sensu (1) intended for receiving a biopharmaceutical product or device; a second, outer, envelope (8) which is closed, delimiting a second space (9) in which is located the first envelope/pouch stricto sensu (1); a spacer element (11); at least one tracer gas located in the first space (6) or in the intermediate space (14) at a partial pressure different from that of the intermediate space or of the first space; and at least one colorimetric detection layer (12), responding to the concentration of tracer gas which reaches it by changing from a first color to a second color, and being an integral part of a wall (3, 4) of the first envelope/defined pouch (1) and/or of a wall (13) of the second envelope and/or of the spacer element.
    Type: Grant
    Filed: August 22, 2011
    Date of Patent: April 14, 2015
    Assignee: Sartorius Stedim FMT SAS
    Inventors: Lars Bottcher, Martin Dahlberg
  • Patent number: 9005979
    Abstract: A method for determining origins of food products, and more specifically for determining geographic and/or biological origin of food products containing alcohols or sugars includes preparing an alcohol sample from a product in question, removing exchangeable hydrogen/deuterium atoms from alcohol molecules of the sample, determining the isotopic composition of non-exchangeable hydrogen/deuterium atoms from sample alcohol, and analyzing results for adulteration or determination of product origin. In addition, alcohol ?13C and ?18O isotopic values, along with ?18O isotopic value of the product water are used for the analysis. Products containing sugar are also subjected to tightly controlled fermentation.
    Type: Grant
    Filed: December 18, 2010
    Date of Patent: April 14, 2015
    Inventor: Ivan Smajlovic
  • Patent number: 9005980
    Abstract: A method including automatically displaying information obtained from a first identifier associated with a slide and a second identifier associated with a reagent cartridge. The method further including generating a staining log based on the information obtained from the first identifier and the second identifier. A further method includes displaying a location of a slide within a sample processing system and information obtained from a first identifier associated with the slide in a first table and displaying a location of a reagent cartridge within a sample processing system and information obtained from a second identifier associated with the reagent cartridge in a second table. The first table is then aligned with the second table.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: April 14, 2015
    Assignee: Sakura Finetek U.S.A., Inc.
    Inventors: Robert E. Evans, Anthony L. Hartman, Richard A. Suchter, Gilles Lefebvre
  • Patent number: 9005981
    Abstract: The present invention is in the field of identification and characterization of novel insecticidal target sites and, in particular, relates to host cells, assays and antibodies thereto.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: April 14, 2015
    Assignee: Dow AgroSciences LLC
    Inventors: Nailah Orr, Gerald B. Watson, Gary D. Gustafson, James M. Hasler, Chaoxian Geng, Scott Chouinard, Kevin R. Cook, Vincent L. Salgado
  • Patent number: 9005982
    Abstract: The present disclosure is generally related to pulmonary autoantigens. The disclosure provides methods and kits for assessing whether a subject has or is predisposed to interstitial lung disease. Additionally the present disclosure provides methods of treatment and animal models of interstitial lung disease.
    Type: Grant
    Filed: June 10, 2011
    Date of Patent: April 14, 2015
    Assignee: The Regents of the University of California
    Inventors: Mark S. Anderson, Anthony K. Shum
  • Patent number: 9005983
    Abstract: The present invention provides an electrochemical sensor having a solid electrically conductive substrate and a compound immobilized thereon which has binding affinity for an analyte species to be detected and also displays electrochemical behavior which is modified upon binding of that analyte species, so that binding of an analyte species can be detected by measuring electrochemical properties, such as by voltammetry. Desirably the immobilized compound contains both a first moiety with binding affinity for the analyte and a separate second moiety which is a redox system whose electrochemical oxidation/reduction properties become modified when the first moiety binds the analyte. The analyte binding moiety may be a diol or polyol and preferably is a sugar. The electrochemical sensor finds use in methods of analyzing reservoir and process fluids, particularly at a subterranean location. The electrochemical sensor may be a component of a downhole tool, adapted for deployment downhole.
    Type: Grant
    Filed: August 26, 2009
    Date of Patent: April 14, 2015
    Assignee: Schlumberger Technology Corporation
    Inventors: Kay McGuinness, Nathan Lawrence, Andrew Meredith
  • Patent number: 9005984
    Abstract: Methods and compositions are disclosed for determining feline proBNP or fragments thereof in a sample. In one method, feline proBNP or fragments thereof are determined by providing a feline sample, contacting the sample with at least one antibody that binds an epitope in the region from amino acids 68 to 80 of feline proBNP, and determining the presence of the feline proBNP or fragments thereof present in the sample. Antibodies that bind feline proBNP and kits comprising such antibodies are also disclosed.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: April 14, 2015
    Assignee: Biomedica Medizinprodukte GmbH & Co KG
    Inventors: Wolfgang Woloszczuk, Gerhard Hawa
  • Patent number: 9005985
    Abstract: This invention provides compositions that have a light emitting reporter linked to biomolecules, preferably, nucleotide oligomers. The light reporter particles are silylated and functionalized to produce a coated light reporter particle, prior to covalently linking the biomolecules to the light reporter particle. The light reporter particles of the invention can be excited by a light excitation source such as UV or IR light, and when the biomolecule is DNA, the attached DNA molecule(s) are detectable by amplification techniques such as PCR.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: April 14, 2015
    Assignee: APDN (B.V.I.) Inc.
    Inventors: Thomas Kwok, Benjamin MingHwa Liang, Stephane Shu Kin So
  • Patent number: 9005986
    Abstract: A method for rapidly measuring melatonin adulteration of Chinese patent medicines and healthcare foods comprises: (1) extracting melatonin added to a Chinese patent medicine or healthcare food by using ethyl acetate; and (2) adding p-dimethylaminocinnamaldehyde to the extracted solution, and observing color. The method is rapid, simple and convenient, has strong specificity, high accuracy, reaction sensitivity, and a wide application range, and is applicable to on-site detection of melatonin adulteration of a Chinese patent medicine or healthcare food.
    Type: Grant
    Filed: July 2, 2012
    Date of Patent: April 14, 2015
    Assignee: Shenzhen Institute For Drug Control
    Inventors: Tiejie Wang, Yi Lu, Lihe Xiao, Xiaoying Guan, Dongqi Han, Guo Yin, Jue Wang, Xueqing Li, Yan Yan
  • Patent number: 9005987
    Abstract: Described herein are methods for quantitative target detection in a sample through use of microbeads and related devices and systems.
    Type: Grant
    Filed: April 15, 2010
    Date of Patent: April 14, 2015
    Assignees: University of Southern California, California Institute of Technology
    Inventors: Emil P. Kartalov, Axel Scherer, Clive R. Taylor
  • Patent number: 9005988
    Abstract: A method for the assessment of a multiphase (aqueous and organic) sample phase, the method comprising adding at least one detection molecule to the multiphase sample; detecting a signal emitted from the detection molecule/multiphase sample mixture, the signal being detectably different when the at least one detection molecule is present in one of either an organic phase, an aqueous phase or an interface between said organic phase and said aqueous phase of the multiphase sample; and analyzing the detected signal to assess the properties of a phase or an interface between phases. A system for use in such a method, use of at least one detection molecule for the assessment of a multiphase sample, and a composition for use in the assessment of a multiphase sample are also disclosed.
    Type: Grant
    Filed: July 20, 2009
    Date of Patent: April 14, 2015
    Assignee: Lux Innovate Limited
    Inventors: Emma Perfect, Catherine Rowley-Williams, Cameron Mackenzie, Artin Moussavi
  • Patent number: 9005989
    Abstract: The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.
    Type: Grant
    Filed: March 3, 2011
    Date of Patent: April 14, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: James Douglas Harper, Richard Hart Mathews, Bernadette Johnson, Martha Susan Petrovick, Ann Rundell, Frances Ellen Nargi, Timothy Stephens, Linda Marie Mendenhall, Mark Alexander Hollis, Albert M. Young, Todd H. Rider, Eric David Schwoebel, Trina Rae Vian
  • Patent number: 9005990
    Abstract: The present invention concerns a method of purifying colistin using reverse phase chromatography, wherein loading a column with colistin base in acetic acid and high ethanol concentration and eluting with low ethanol concentration is performed.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: April 14, 2015
    Assignee: Xellia Pharmaceuticals APS
    Inventors: Torben Koch, Carsten Overblle Petersen
  • Patent number: 9005991
    Abstract: Devices and methods for testing a biological sample for an analyte of interest are provided that make use of a reaction chamber for receiving a reaction mixture, a housing positioned below the reaction chamber for receiving a test cassette, and a door that is positioned in the top portion of the housing. The door includes a ramp that extends downwardly into the housing such that biasing the ramp upwards opens the door into the cavity of the reaction chamber and places the reaction chamber in fluid communication with the insertion area to thereby allow the reaction mixture to flow onto a test cassette and allow for the determination of an amount of an analyte of interest.
    Type: Grant
    Filed: January 5, 2012
    Date of Patent: April 14, 2015
    Assignee: American Bio Medica Corporation
    Inventors: Douglas Casterlin, Larry Ferringo
  • Patent number: 9005992
    Abstract: The present invention relates to a novel fusion protein comprising Staphylococcal protein A and mussel adhesive protein, a biochip comprising a solid substrate to which the fusion protein is attached, and a method for detecting a target antigen in a biological sample using the biochip. Furthermore, the present invention relates to a polynucleotide encoding the fusion protein, a recombinant vector comprising the polynucleotide, a transformed cell comprising the recombinant vector, and a method of preparing the fusion protein by transformed cell comprising the recombinant vector.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: April 14, 2015
    Assignee: Postech Academy-Industry Foundation
    Inventors: Hyung Joon Cha, Chang Sup Kim
  • Patent number: 9005993
    Abstract: The present disclosure provides methods and/or kits for detecting an analyte in a sample. Some embodiments provide a method for detecting a non-nucleic acid analyte in a sample using a solid substrate comprising a bound immobilization agent and an antibody capture agent and a detectable agent, which can bind to the analyte. The antibody capture agent comprises, at a plurality of sites, a ligand for the immobilization agent. A complex between the analyte, the antibody capture agent and a detectable agent is formed and immobilized on the solid substrate by binding between the immobilization agent and the ligand. In some embodiments, the ligand and the immobilization agent are a binding pair comprising a peptide tag and an anti-peptide tag antibody.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: April 14, 2015
    Assignee: TGR BioSciences Pty Ltd.
    Inventors: Antony James Sheehan, Ronald Ian William Osmond, Michael Francis Crouch, Anthony Ross Dyer
  • Patent number: 9005994
    Abstract: The present application pertains to improved methods of detecting biomolecules in a biological sample (or system), In particular, embodiments discussed herein allow for the detection of biomolecule complexes. The embodiments enable for the first time the elucidation of the significance of biomolecule complexes for certain disease states, which in turn enables the diagnosis of disease states based on the identity and complexing level of a biomolecule complex in a particular biological sample.
    Type: Grant
    Filed: January 12, 2011
    Date of Patent: April 14, 2015
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventor: Qun Huo
  • Patent number: 9005995
    Abstract: The present invention relates to a nanoscale or microscale particle for encapsulation and delivery of materials or substances, including, but not limited to, cells, drugs, tissue, gels and polymers contained within the particle, with subsequent release of the therapeutic materials in situ, methods of fabricating the particle by folding a 2D precursor into the 3D particle, and the use of the particle in in-vivo or in-vitro applications. The particle can be in any polyhedral shape and its surfaces can have either no perforations or nano/microscale perforations. The particle is coated with a biocompatible metal, e g gold, or polymer e g parvlene, layer and the surfaces and hinges of the particle are made of any metal or polymer combinations.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: April 14, 2015
    Assignee: The Johns Hopkins University
    Inventors: David H. Gracias, Timothy Gar-Ming Leong, Hongke Ye
  • Patent number: 9005996
    Abstract: The current invention is a capture-particle comprising: a) a molecular sieve portion; and b) an analyte binding portion; wherein the molecular sieve portion, analyte binding portion or both further comprise a cross-linked region having modified porosity. Capture particles wherein the molecular sieve portion, analyte binding portion or both comprise pore dimensions sufficient to exclude molecules larger than about 60 kDa. These particles are useful in purification and diagnostic methods. Kits comprising the capture particles are also described.
    Type: Grant
    Filed: September 27, 2006
    Date of Patent: April 14, 2015
    Assignee: George Mason Research Foundation
    Inventors: Lance Liotta, Emanuel Petricoin, David Geho
  • Patent number: 9005997
    Abstract: Provided are a magneto resistive element and a method of manufacturing the same, and in particular, a magneto resistive element and a method of manufacturing the same that may be applied to a digitizer sensing panel. The magneto resistive element includes a substrate, a first electrode disposed on the substrate, a first hole transport layer disposed on the first electrode, a first magneto resistive layer disposed on the first hole transport layer, wherein the first magneto resistive layer comprises an organic material, a first transport layer disposed on the first magneto resistive layer, a second magneto resistive layer disposed on the first transport layer, wherein the second magneto resistive layer comprises an organic material, a first electron transport layer disposed on the second magneto resistive layer, and a second electrode disposed on the first electron transport layer.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: April 14, 2015
    Assignee: Samsung Display Co., Ltd.
    Inventors: Hyun-Sung Bang, Won-Jong Kim, Ji-Young Choung, Joon-Gu Lee, Jin-Baek Choi, Yeon-Hwa Lee
  • Patent number: 9005998
    Abstract: A laser annealing apparatus reduces laser annealing time and has a simple configuration. A laser annealing method is used to manufacture a display apparatus. The laser annealing apparatus includes a mounting unit, a substrate mounted on the mounting unit, first and second driving modules installed on the mounting unit and adjusting locations of first and second mark masks to be placed on a part of the substrate, first and second image modules that may obtain image data regarding the first and second mark masks to be location-adjusted by first and second driving modules, and a laser module that radiates a laser beam to the substrate and changes at least a part of an amorphous silicon layer of the substrate to crystalline silicon.
    Type: Grant
    Filed: July 16, 2013
    Date of Patent: April 14, 2015
    Assignee: Samsung Display Co., Ltd.
    Inventors: Cheol-Ho Park, Byung-Sul Kim, Jong-Hyun Yun, Hee-Geun Son
  • Patent number: 9005999
    Abstract: Methods for chemical mechanical polishing (CMP) of semiconductor substrates, and more particularly to temperature control during such chemical mechanical polishing are provided. In one aspect, the method comprises polishing the substrate with a polishing surface during a polishing process to remove a portion of the conductive material, repeatedly monitoring a temperature of the polishing surface during the polishing process, and exposing the polishing surface to a rate quench process in response to the monitored temperature so as to achieve a target value for the monitored temperature during the polishing process.
    Type: Grant
    Filed: June 30, 2012
    Date of Patent: April 14, 2015
    Assignee: Applied Materials, Inc.
    Inventors: Kun Xu, Jimin Zhang, David H. Mai, Stephen Jew, Shih-Haur Walters Shen, Zhihong Wang, Thomas H. Osterheld, Wen-Chiang Tu, Gary Ka Ho Lam, Tomohiko Kitajima
  • Patent number: 9006000
    Abstract: A semiconductor device, such as a semiconductor die, is disclosed including embedded temperature sensors for scanning the junction temperature, Tj, at one or more locations of the semiconductor die while the die is operating. Once a temperature of a hot spot is detected that is above a temperature specified for the die or package containing the die, the die/package may be discarded. Alternatively, the functionality of the die may be altered in a way that reduces the temperature of the hot spots.
    Type: Grant
    Filed: May 3, 2012
    Date of Patent: April 14, 2015
    Assignee: SanDisk Technologies Inc.
    Inventors: Deny Hanan, Eddie Redmard, Itai Dror