Abstract: A method for screening compounds for their ability to interact with transmembrane proteins is provided. Also provided is a method for determining whether proteins such as transmembrane proteins are able to oligomerise.

Abstract: Provided herein are screening methods for identifying arthropod repellent compounds based on modulation of ionotropic receptors, including an Ir40a receptor, an Ir93a receptor and an Ir25a receptor. Further provided are screening systems related to these methods. Such systems may include a sample that has one or more of the ionotropic receptors; and one or more compounds that each is a repellent for at least one arthropod species, wherein the one or more compound each modulates the activity of such ionotropic receptor(s). Further provided are one or more compounds identified using the screening methods described herein, and compositions containing such compounds.

Abstract: The present invention relates to a microarray comprising at least 50,000 oligopeptide features per cm2 where the oligopeptide features represent at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, at least 95%, at least 99%, or 100% of the proteome of a virus or an organism. The present invention further relates to methods for the synthesis of such microarrays and methods of using microarrays comprising at least 50,000 oligopeptide features per cm2. In an embodiment of the invention, the oligopeptide features represent proteins expressed in the same species, wherein the oligopeptide features are presented in a tiling pattern representing at least about 5,000, at least about 10,000, at least about 15,000, at least about 20,000, or at least about 25,000 proteins expressed in a species.

Abstract: Disclosed is a molecular library comprising a group of a plurality of molecules, wherein each member of the library is a polypeptide having a randomized sequence moiety and a microprotein moiety. The microprotein is a protein comprising an amino acid sequence of 30 or less amino acid residues having the ability to form a particular conformation by spontaneous folding in a solution and is, for example, chignolin comprising the amino acid sequence represented by SEQ ID NO: 1. Also, disclosed is a method for identifying a novel functional molecule using the library of the present invention.

Abstract: Methods, devices, and systems are disclosed for performing high throughput analysis of conformational change in biological molecules or other biological entities using surface-selective nonlinear optical detection techniques.

Abstract: A point of care immunization system based upon a range of detection methods to rapidly test a patient in order to ascertain an immunization profile so that vaccinations can be administered to address identified gaps. A point of care system comprised of sample and test strips/cartridges, with said test strips/cartridges configured to meet healthcare requirements of national governing bodies. A point of care system that can function as a stand-alone diagnostic system, stand-alone kit or with a device.

Abstract: A method of detecting antibodies to syphilis antigens includes providing a syphilis detection kit having a screening solid-phase platform with a screening portion coated with non-treponemal syphilis antigens. The screening portion is fabricated by initially dissolving cholesterol in an organic solvent and further diluting the dissolved cholesterol in an ethanol solution comprising cardiolipin and lecithin to form an antigen solution, permitting the antigen solution to evaporate at the screening portion and at least partially coating the screening portion with an antigen coating, and stabilizing the antigen coating into a syphilis antigen complex by overcoating the antigen coating with an overcoat solution comprising an inert protein.

Abstract: Methods, compositions, and kits for predicting whether a subject with chronic obstructive pulmonary disease (COPD) or at risk of developing COPD is likely to have progressive COPD are provided. Methods, compositions, and kits for predicting whether lung function is likely to decline in a subject with COPD or at risk for developing COPD are also provided.

Abstract: A method of classifying a lung graft subjected to normothermic ex vivo lung perfusion (EVLP), during perfusion and/or after perfusion, the method comprising: a) collecting a test sample from the lung graft; b) measuring a polypeptide level of a negative transplant predictor gene product selected from CCG predictor gene products M-CSF, IL-8 SCGF-beta, GRO-alpha, G-CSF, MIP-1 alpha, and/or MIP-1beta, endothelin predictor gene products endothelin 1 (ET-1) and/or big ET-1, and/or apoptosis predictor gene products cytokeratin 18 (CK-18), caspase 3 and/or HMGB-1 in the sample and/or determining a metabolite profile of the sample for lung grafts that are from donors where the death was due to cardiac death (DCD); c) identifying the graft as a good candidate for transplant or a poor candidate for transplant wherein an increased polypeptide level of one or more negative transplant outcome predictor gene products compared to an outcome control or a reference metabolic profile is indicative the graft is a poor candidate

Abstract: Methods for diagnosis of Kawasaki disease (KD) are disclosed. In particular, the invention relates to the use of biomarkers for aiding diagnosis, prognosis, and treatment of KD, and to a panel of biomarkers that can be used to distinguish KD from febrile illness.

Abstract: Panels of 1-, 2-, 3-, and 4 protein-biomarker for diagnostic and prognostic methods to determine a subject's radiation exposure and discriminates between persons who have been exposed to various levels of radiation, 1-5 days after exposure.

Abstract: The present invention provides a method of diagnosing rheumatoid arthritis (RA), comprising: testing a sample from a subject for the presence or absence of antibodies against oxidised collagen II; wherein the presence of antibodies against oxidised collagen II in the sample is indicative of RA in the subject. The present invention also provides a method for identifying whether a subject responds to a disease modifying anti-rheumatic drug (DMARD) and related methods of treating RA, a method for identifying whether a subject responds to an anti-TNF biologic and related methods of treating RA, and a method of diagnosing osteoarthritis (OA).

Abstract: Methods for the treatment and monitoring of diabetic retinopathy are provided. More specifically, the method for the treatment of diabetic retinopathy comprises administering to an individual suspected of having diabetic retinopathy a composition comprising an agent that inhibits the activity or expression of EMAPII or CXCR3. Methods for diagnosing and monitoring the progression of diabetic retinopathy in an individual, or monitoring the efficacy of a therapy for diabetic retinopathy are provided. More specifically, the method comprises determining the levels of EMAPII in a biological sample from an individual and comparing them to a control or reference sample, or a chronological sample from the individual.

Abstract: Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).

Abstract: The present invention provides various biomarkers of fatty liver disease, including steatosis and steatohepatitis. The present invention also provides various methods of using the biomarkers, including methods for diagnosis of fatty liver disease, methods of determining predisposition to fatty liver disease, methods of monitoring progression/regression of fatty liver disease, methods of assessing efficacy of compositions for treating fatty liver disease, methods of screening compositions for activity in modulating biomarkers of fatty liver disease, methods of treating fatty liver disease, as well as other methods based on biomarkers of fatty liver disease.

Abstract: Certain embodiments include methods for assessing a subject having a trypanosome infection for the presence or absence of indications of cardiomyopathy.

Abstract: The present invention provides a method of determining and treating amyotrophic lateral sclerosis (ALS) in a subject, comprising the following steps: (1) measuring a concentration of an autoantibody against high mobility group box 1 protein (HMGB1) in a biological sample from the subject; and (2) administering an effective amount of ALS-treating drug to the subject whose measured concentration of the autoantibody against HMGB1 is higher than 0.874 ?g/ml.

Abstract: A sample acquiring device, an apparatus and a method for spectrophotometric measurement of high density lipoprotein (HDL) and at least one of total cholesterol (TC), triglycerides (TG) and glucose (FPG).

Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

Abstract: A method, system, and sensor for air flow sensing. The system can include a cantilever, a transducer, and a processing module. The method can include measuring beam deflections of one or more cantilevers, extracting information about air flow, and determining one or more of an airspeed, an angle of attack, and a sideslip, based on extracted information. The system and method can exploit nonlinearities in the behavior of the cantilever in fluid flow.

Abstract: Systems and methods are disclosed herein for extracting system parameters from nonlinear periodic signals from sensors. A sensor such as an inertial device includes a first structure and a second structure that is springedly coupled to the first structure. The sensor is configured to generate an output voltage based on a current between the first and second structures. Monotonic motion of the second structure relative to the first structure causes a reversal in direction of the current.

Abstract: Systems and methods are disclosed herein for extracting system parameters from nonlinear periodic signals from sensors. A sensor such as an inertial device includes a first structure and a second structure that is springedly coupled to the first structure. The sensor is configured to generate an output voltage based on a current between the first and second structures. Monotonic motion of the second structure relative to the first structure causes a reversal in direction of the current.

Abstract: Systems and methods are disclosed herein for extracting system parameters from nonlinear periodic signals from sensors. A sensor such as an inertial device includes a first structure and a second structure that is springedly coupled to the first structure. The sensor is configured to generate an output voltage based on a current between the first and second structures. Monotonic motion of the second structure relative to the first structure causes a reversal in direction of the current.

Abstract: An acceleration sensor includes a base substrate provided with a first recess part, and a sensor part located on the first recess part and swingably supported in a depth direction of the first recess part by a support part, wherein the sensor part is sectioned into a first part and a second part by the support part, includes a movable electrode part in the first part and the second part, a through hole is provided at least at an end side in the second part larger in mass than the first part, and the base substrate includes a fixed electrode part in a position opposed to the movable electrode part in the first recessed part, and a second recess part deeper than the first recess part is provided in a position opposed to the end side of the sensor part.

Abstract: Systems and techniques for varying a scan rate in a measurement instrument. The techniques may be used in scanning probe instruments, including atomic force microscopes (AFMs) and other scanning probe microscopes, as well as profilometers and confocal optical microscopes. This allows the selective imaging of particular regions of a sample surface for accurate measurement of critical dimensions within a relatively small data acquisition time.

Abstract: System for performing in-line nanoprobing on semiconductor wafer. A wafer support or vertical wafer positioner is attached to a wafer stage. An SEM column, an optical microscope and a plurality of nanoprobe positioners are all attached to the ceiling. The nanoprobe positioners have one nanoprobe configured for physically contacting selected points on the wafer. A force (or touch) sensor measures contact force applied by the probe to the wafer (or the moment) when the probe physically contacts the wafer. A plurality of drift sensors are provided for calculating probe vs. wafer alignment drift in real-time during measurements.

Abstract: The purpose of the present invention is to increase the detection light amount of near-field light, which is generated in a liquid between a measurement probe and a sample-to-be-inspected, at the time of employing a near-field scanning microscope for measurement in a liquid, and to improve measurement reproducibility and the SN ratio of near-field light images. The present invention provides a scanning probe microscope comprising: a measurement probe that is relatively scanned over a sample-to-be-inspected; a laser beam irradiation system that irradiates the measurement probe with a laser beam; a sample cell that holds the sample-to-be-inspected and that transmits scattered light of near-field light generated between the measurement probe and the sample-to-be-inspected by the laser beam irradiation; and a detector that detects the scattered light that has passed through the sample cell.

Abstract: Provided is a test socket having high-density conduction sections. The test socket is configured to be disposed between a device to be tested and a test apparatus for electrically connecting terminals of the device and pads of the test apparatus.

Abstract: The present invention relates to a socket device for testing a semiconductor device. More particularly, the present invention relates to a socket device that is capable of testing ball grid array (BGA) and land grid array (LGA) type semiconductor devices, or BGA/LGA hybrid semiconductor devices according to the shapes of leads of the semiconductor devices. A latch structure for pressing and holding a semiconductor device is improved such that a roller is provided at the front end of a latch so as to minimize wear caused by friction with a sandpaper-like surface on an upper surface of the semiconductor device, even in the case of approximately one hundred thousand or more rounds of testing, thereby remarkably extending the life of the socket device, increasing testing efficiency, and reducing costs.

Abstract: The present invention relates to a spring contact, which is integrally formed by blanking and bending a metal plate member, the spring contact comprising: an upper head portion 32 having an upper tip 31 protruding upward; a spring portion (36) formed by a strip cylindrically bent, the strip extending in a zigzag pattern from an upper connection portion 35 extending downward from the upper head portion 32; a lower head portion 39 extending downward from a lower connection 37 extending from the lower end of the spring portion 36; and a lower tip 40 being provided on the lower end of the lower head portion 39. The present invention is advantageously suitable for manufacturing a fine-pitch spring contact and can improve productivity and reduce manufacturing costs.

Abstract: A positioner and a probe head of a probe card are provided. The positioner has a main opening, a first sub-opening, a second sub-opening, a third sub-opening, a fourth sub-opening, a first positioning portion, a second positioning portion, a first elastic portion and a second elastic portion. The first sub-opening, the second sub-opening, the third sub-opening, and the fourth sub-opening are sequentially arranged at the periphery of the main opening and are communicated to the main opening. A stiffness of the first positioning portion and a stiffness of the second positioning portion are higher than a stiffness of the first elastic portion and a stiffness of the second elastic portion.

Abstract: A meter cover removal detection arrangement includes a switch element, a pivoting lever arm, a meter cover and a plunger. The switch element has first and second positions, and conducts electricity between first and second contacts in only one of the first position and the second position. The pivoting lever arm has two arm positions, and is operably coupled to cause the switch element to be in the second position when the lever arm is in a second arm position. The lever arm engages a spring that biases the level arm toward the second arm position. The meter cover has an inward extending cam. The plunger has first and second plunger positions, and is operably coupled to hold the pivoting lever arm in the first arm position when the plunger is in the first plunger position. The cam engages the plunger to hold the plunger in the first plunger position when the meter cover is installed on a meter base. The cam is disengaged from the plunger when the meter cover is removed.

Abstract: A voltage measuring device that can contactlessly measure a direct-current voltage of a measurement target is provided. For that purpose, the voltage measuring device includes: a dielectric body provided so as to be able to face a conductor of a measurement target; an electrode provided on the dielectric body; a capacitor that, upon being connected to the electrode, holds a potential having a one-to-one correlation with a potential of the electrode; and a switch provided so as to be able to connect the electrode and the capacitor, and upon the electrode and the capacitor being disconnected, enable a voltage between opposite ends of the capacitor to be output.

Abstract: A detecting unit is presented. The detecting unit includes a flexible circuit having a first side and a second side opposite the first side. The flexible circuit includes a plurality of cells defined therein, each of the plurality of cells having a first side and a second side respectively corresponding to the first side and the second side of the flexible circuit. Moreover, the flexible circuit includes a plurality of conductive windings disposed on at least one of the first and second sides of the plurality of cells. Further, the flexible circuit includes a stress reduction feature between each of the plurality of cells. Also, the detecting unit includes a sealing element configured to secure the flexible circuit in a stacked configuration. A sensing system and a method of making a detecting unit are also presented.

Abstract: There is provided a neutral pole transformer module for a circuit breaker capable of minimizing an influence of external noise, detecting a neutral pole current at low manufacturing cost, and detecting a neutral pole current without modifying a configuration of an existing overcurrent relay or without installing an additional component in the existing overcurrent relay. The neutral pole transformer module for a circuit breaker comprises a ZCT configured to allow a transmission line of a neutral pole detection current output from the current transformer to pass therethrough and to provide a secondary output current signal obtained by reducing the neutral pole detection current in a predetermined ratio; a printed circuit board configured to convert the secondary output current signal into a voltage signal, and to differentiate the converted voltage signal and output the same; and an enclosure formed of an electrical insulator and enclosing the ZCT and the PCB.

Abstract: A semiconductor arrangement may comprise a multiplicity of semiconductor elements with controlling paths and controlled paths, the controlled paths having controllable conductivities and being connected parallel to each other. The semiconductor arrangement may also comprise a current evaluation circuit configured to measure current strengths of currents present in the controlled paths and to provide a signal representing the sum of the measured current strengths, and a control circuit connected to the controlling paths and configured to control the conductivities of the controlled paths in accordance with an input signal and the signal representing the sum of the current strengths, wherein at least one controlled path is controlled to have minimum conductivity if the signal representing the sum of the current strengths is below a threshold value.

Abstract: An electric current sensor includes a core having a coupling portion formed by bending a part of a plate member, and one end portion and the other end portion of the plate member are disposed to oppose to each other through a constant magnetic gap on a side opposite from the coupling portion. The core has: a first tapered portion in which a width of the plate member continuously decreases from one end of the coupling portion adjacent to the one end portion to a distal end of the one end portion; and a second tapered portion in which the width of the plate member continuously decreases from an other end of the coupling portion adjacent to the other end portion to a distal end of the other end portion.

Abstract: A current sense circuit for a PWM driver comprises: a PWM control circuit comprising: a first switching device arranged to receive a PWM signal from the PWM driver whose current is to be sensed; and a second switching device whose supply current is arranged to track the sensed current of the PWM driver. An ADC is operably coupled to the first and second switching device. The ADC comprises: a DAC arranged to provide a current sense to the second switching device that tracks the current passing through the PWM driver; a first comparator arranged to receive and compare an output current from the DAC and an output current from the first switching device; and a first successive approximation register arranged to receive an output from the comparator and provide: a first output to the ADC; and a second output that provides a representation of the sensed current.

Abstract: Embodiments herein provide an energy measuring unit, compatible with a circuit breaker in a distribution board, for measuring energy usage information. The energy measuring unit includes a voltage input terminal, and a voltage measuring unit electrically, connected to the voltage input terminal, configured to measure a voltage value. The energy measuring unit measures energy usage information using the voltage value. Further, the energy measuring unit includes a communication unit configured to communicate the energy usage information to a remote electronic device. In an embodiment, the voltage input terminal is configured to fix the energy measuring unit to the distribution board to receive voltage from a busbar of the distribution board. The energy measuring unit is configured to be compatible with a branch circuit breaker coupled with the busbar of the distribution board.

Abstract: Disclosed herein are signal identification methods and systems. In some examples, the method and/or system allows appliances to be associated with their electrical usage. In one example, a method for determining whether a load is in a steady state or in transition includes analyzing a time series of electric power or current measurements on at least one circuit, at least one load coupled to the at least one circuit; and determining whether the load is in a steady state or a transition. Also disclosed is an appliance identification method. Further disclosed is a method of mapping unlabeled appliances which utilizes a STEC Table which summarizes linkages between transitions and steady state clusters.

Abstract: A method for determining power output levels of a plurality of nodes in an electric power system includes receiving, at a first node of the plurality of nodes, voltage information and multipliers of all neighboring nodes of the first node within the electric power system, determining, by the first node, a local power generation and a local voltage using the voltage information and the multipliers of the neighboring nodes and distributing the local power generation and the local voltage to the neighboring nodes, determining, by the first node, an estimated voltage of each of the neighboring nodes and distributing the estimated voltage to each of the neighboring nodes, and updating, by the first node, a local multiplier using the voltage information received from the neighboring nodes and the estimated voltage of each of the neighboring nodes determined by the node.

Abstract: A power consumption measurement method for operating an electronic component during an interval of time includes: logging power states that the component adopts during the interval, interrogating the log to determine the amount of time that the component spent in each power state during interval, and multiplying the rated power consumption for each state by the amount of time spent in each respective state. The power consumptions for each of the states are summed to determine a total power consumption of the component during the interval. Logging the power states may be achieved by counting command line instructions of different types, thus identify the beginning and end of each power state, during the interval. The method may be used to measure and/or benchmark the actual power consumption of a DDR RAM module. An apparatus for carrying out the method is also disclosed.

Abstract: A system that uses power spectrum analysis and auto-correlation function analysis to perform seasonality estimation of time series data. A power spectrum analyzer calculates and analyzes a power spectrum of a received time series data. An auto-correlation function analyzer calculates at least one auto-correlation function of the received time series, and generates a resulting set of one or more candidate seasonalities. A seasonality estimator estimates one or more seasonalities of the received time series using at least a portion of the analyzed result from the power spectrum analyzer and using the set of one or more candidates generated by the auto-correlation function analyzer. Accordingly, the estimation of candidate seasonality uses both auto-correlation and power spectrum analysis, thereby at least in some circumstances improving the seasonality estimation compared to auto-correlation function analysis alone or power spectrum analysis alone.

Abstract: A voltage/current verifier computes, for each phase, a phase difference between phase voltage and phase current from the phase of phase voltage and the phase of phase current computed for each phase by a phase acquirer, and determines conformity if all of the computed phase differences are within a preset range. A current/current verifier computes phase differences between phase currents from the phase of phase current computed for each phase by the phase acquirer, and determines conformity if all of the computed phase differences are less than 180°. A reporting device reports that a current transformer is incorrectly placed on a power line unless both the voltage/current verifier and the current/current verifier do not determine conformity.

Abstract: A bobbin and coil architecture is provided for use in an inductive sensor. The architecture eliminates the need for coil shielding and reduces the sensor's sensitivity to temperature and proximate mounting hardware. In one or more embodiments, all or portions of separate coils are located in a common slot on the bobbin, rather than being segregated into separate slots. In an example configuration, two receiver coils may be located in respective two slots on the bobbin, and a transmitter coil may divided into two substantially equal subsets of windings, with each subset wound together with one of the receiver coils in a common slot. This yields a symmetrical and balanced winding architecture that requires fewer slots relative to designs that segregate all coils into separate slots.

Abstract: A pre-characterised high frequency signal (14) is provided by means of a non-linear circuit, for example an amplifier circuit (10), fed with a first signal (12) with a component at a first, fundamental, frequency (FO). The amplifier circuit generates an output signal comprising harmonic components (14h1, 14h2, 14h3) having stable and predetermined phase relation relative to each other. Information concerning the phase relation of the harmonic frequency components is provided, for example by means of a data file (16). At least two of the harmonic components are at the tenth or lower harmonic frequencies. The signal strength of such low-order harmonic components may be relative high, thus enabling the provision of a pre-characterised high frequency multi-tone signal from the amplifier circuit with high signal to noise ratio.

Abstract: An electronic device is provided. The electronic device includes a printed circuit board (PCB), an antenna structure, a radio frequency signal transceiving circuit and a testing structure. The antenna structure is disposed on the PCB. The radio frequency signal transceiving circuit is disposed on the PCB, and is connected to the antenna structure through a conductive line. The testing structure includes a testing point and a grounding structure. The testing point is disposed on the conductive line, and the grounding structure is disposed on the PCB.

Abstract: A tester for testing a transformer is provided. The tester comprises a primary voltmeter and a plurality of secondary voltmeters. The tester may also comprise an ammeter in series with a voltage source configured to apply voltage to the transformer. The primary voltmeter is configured to measure voltage induced across a primary winding of the transformer, while the secondary voltmeters may simultaneously measure voltage outputs at secondary windings of the transformer. The tester is configured to calculate ratios, saturation curves, and knee points for multiple winding combinations based on the measurements simultaneously obtained by the ammeter and the primary and secondary voltmeters.

Abstract: Provided is an electronic apparatus that can prevent erroneous detection of a sensor output due to an AC line noise. A power supply circuit includes a noise filter, input rectifying smoothing circuit, converter circuit, and output smoothing circuit. The input rectifying smoothing circuit rectifies an input AC voltage passed through the noise filter to a pulsating flow and then smooth it. The converter circuit converts a DC voltage rectified and smoothed into a desired output voltage. The output smoothing circuit smoothes the convert output voltage to supply it to a control part. The noise determination part detects a noise that could not have been removed by the noise filter, as an AC line noise. The control part invalidates a detection signal outputted from the sensor for a previously set invalid period from the moment the AC line noise has been detected.

Abstract: An electrical circuit for a mobile machine, including an interface coupled between a controller and a plurality of sensors for accurately diagnosing faults in all of the sensor wires and the sensors themselves. This effective resolution reduces the downtime of the mobile machine and operator time by allowing faults to be timely isolated. The interface selectively couples a test signal to each of the sensor conductors, and also selectively couples a responsive returned characteristic signal to the controller, where the returned characteristic signal enables the controller to diagnose each of the plurality of conductors and sensors for faults. The electrical circuit may further include testing circuitry that can specifically determine a location of the determined fault in each of the plurality of conductors or each of the plurality of sensors.