Abstract: The present invention is directed to the combination therapy of an afucosylated anti-CD20 antibody with an anti-VEGF antibody for the treatment of cancer, especially to the combination therapy of CD20 expressing cancers with an afucosylated humanized B-Ly1 antibody and an anti-VEGF antibody.

Abstract: The invention relates to human targets of interest (TOI), anti-TOI ligands, kits compositions and method.

Abstract: The invention relates to anti-Factor D antibody variants, their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation.

Abstract: Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to EGFR are provided. Methods of using the agents, antibodies, or immunoconjugates, such as methods of inhibiting tumor growth are further provided.

Abstract: An anti-cancer drug compound comprises a spermidine/spermine N1-acetyltransferase antibody. The spermidine/spermine N1-acetyltransferase antibody may be a monoclonal antibody or a polyclonal antibody. A method of treating cancer comprises the use of a spermidine/spermine N1-acetyltransferase antibody. The spermidine/spermine N1-acetyltransferase antibody may be a monoclonal antibody or a polyclonal antibody.

Abstract: Disclosed herein are antibodies capable of binding to plasma kallikrein and inhibit its activity. Such antibodies interact with one or more critical residues in the catalytic domain of the plasma kallikrein. The antibodies may also contain specific heavy chain complementarity determining region 3 (CDRs) motifs and optionally specific residues at certain positions within both the heavy chain variable region and the light chain variable region.

Abstract: The invention relates to human targets of interest (TOI), anti-TOI ligands, kits compositions and method.

Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of three polypeptides: a) a polypeptide chain of formula (I): (Vxx)nVx-Cx-X—V1; and b) a polypeptide chain of formula (II): (Vyy)nVy-Cy c) a polypeptide of formula (III):V2 wherein Vx represents a variable domain, Vxx represents a variable domain, Cx represents a constant region, X represents a linker, V represents a variable domain, Vy represents a variable domain, Vyy represents a variable domain, Cy represents a constant region, V2 represents a variable domain, n independently represents 0 or 1, wherein the polypeptide chain of formula (I) and the polypeptide chain of formula (II) is aligned such that the constant regions Cx and Cy are paired and the variable domains Vx and Vy are paired to form a binding domain and optionally a disulphide bond is present between V and V2, in particular where a disulphide bond is present.

Abstract: Methods, compositions and uses are provided for bispecific antibodies comprising one or more unnatural amino acids. The bispecific antibodies may bind to two or more different receptors, co-receptors, antigens, or cell markers on one or more cells. The bispecific antibodies may be used to treat a disease or condition (e.g., cancer, autoimmune disease, pathogenic infection, inflammatory disease). The bispecific antibodies may be used to modulate (e.g., stimulate or suppress) an immune response.

Abstract: An adsorbent of the present invention includes a support; and a protein having an adsorption site for adsorbing a target substance, in which the protein includes a reversible binding site and a covalent binding site, the support includes an orientation-controlling site forming a reversible bond with the reversible binding site, and an immobilization site forming a covalent bond with the covalent binding site, the covalent binding site includes a nucleophilic functional group, and the immobilization site includes a functional group capable of reacting with the nucleophilic functional group by a nucleophilic substitution or a nucleophilic addition. Thus, it is possible to provide an adsorbent in which the utilization efficiency of the adsorption site of the protein is improved. As a result, the protein amount can be reduced, and the step for storing a culture solution can be simplified due to the faster purification step.

Abstract: A hybrid vegetable protein is described, comprising a guest protein having the structure of prolamine and glutelin, and a host protein having the structure of globulin and albumin, obtained from vegetable grains, such as corn and soybean, respectively. Likewise, a method for obtaining said hybrid vegetable protein is described, which comprises the steps of extracting the guest and host proteins, carrying out an acidification thereof, and further applying a magnetic field to provoke their attachment, and finally adding an alkali to the attached proteins to obtain a hybrid vegetable protein at its isoelectric point. The protein thus produced has a value higher than 0.97 according to the PDCAAS rating.

Abstract: The invention is directed to a process for refining prepared biomass to produce hemicellulose hydrolyzates, cellulose of sugars involving the perforate at least a portion of the cells of the prepared biomass prior to hydrolyzing the biomass, reclaiming the catalysts used in hydrolysis, and drying the hydrolysis using reclaimed heat from previous steps in the process.

Abstract: A compound comprising one or more polysaccharide moieties each independently represented by the formula ?(1?4)-[GlcNH—R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.

Abstract: A binder comprising a polymeric binder comprising the products of a carbohydrate reactant and organic acid is disclosed. The binder is useful for consolidating loosely assembled matter, such as fibers. Fibrous products comprising fibers in contact with a carbohydrate reactant and an organic acid are also disclosed. The binder composition may be cured to yield a fibrous product comprising fibers bound by a cross-linked polymer. Further disclosed are methods for binding fibers with the carbohydrate based binder using an organic acid.

Abstract: The present invention relates to a method of and an apparatus for extending the shelf life of an initiated monomer mixture, the method comprising the prevention of premature free radical polymerisation by introducing oxygen or oxygen-containing gas into a container of the initiated monomer mixture and providing mechanical agitation to the container, wherein said introduction and agitation are performed in a temperature and pressure controlled environment.

Abstract: The disclosure generally relates to formation of polymers grafted to or polymerized from the surface of gold nanoparticles. The polymers are functionalized to include therapeutic agents and/or targeting agents at their surface, thereby allowing both therapeutic and targeting compounds to be directed to specific cells in a patient.

Abstract: The present invention provides a polymer compound for a conductive polymer, containing one or more repeating units (a) represented by the following general formula (1), the polymer compound for a conductive polymer being synthesized by ion-exchange of a lithium salt, a sodium salt, a potassium salt, or a nitrogen compound salt of a sulfonic acid residue, and having a weight average molecular weight in the range of 1,000 to 500,000. There can be provided a polymer compound for a conductive polymer having a specific superacidic sulfo group which is soluble in an organic solvent, and suitably used for a fuel cell or a dopant for a conductive material.

Abstract: A modifying agent includes an acrylic copolymer containing an acrylic acid ester monomer unit, a methacrylic acid ester monomer unit, a monomer unit of a compound represented by Formula (1), and a cationic monomer unit: wherein, in the formula, R1 is a hydrogen atom or a methyl group; R2, R3, and R4 are hydrogen atoms or organic groups having 1 to 10 carbon atoms in which hydrogen does not exist in carbon adjacent to a double bond; R5 is an organic group having 1 to 10 carbon atoms in which hydrogen does not exist in carbon adjacent to a double bond; X2 is a hydrogen atom; Y is or —O—; and n is 1 or 0.

Abstract: The present invention provides a polymer compound for a conductive polymer, containing one or more repeating units (a) represented by the following general formula (1), the polymer compound for a conductive polymer being synthesized by ion-exchange of a lithium salt, a sodium salt, a potassium salt, or a nitrogen compound salt of a sulfonic acid residue, and having a weight average molecular weight in the range of 1,000 to 500,000. There can be provided a polymer compound for a conductive polymer having a specific superacidic sulfo group which is soluble in an organic solvent, and suitably used for a fuel cell or a dopant for a conductive material.

Abstract: Disclosed herein are polymerization processes for the production of olefin polymers. These polymerization processes use a catalyst system containing three metallocene components, often resulting in polymers having a reverse comonomer distribution and a broad and non-bimodal molecular weight distribution.

Abstract: A process for preparing a vinyl acetate rich polymer for formulating surfactant containing compositions comprising at least one anionic surfactant and having yield stress properties without a significant increase in viscosity, low turbidity, and the ability to suspend insoluble materials in the form of particulates and/or droplets that require suspension or stabilization is disclosed.

Abstract: Provided is a (meth)acrylate and a radical curable material with which the sensitivity can be enhanced to improve the curability, the increase in viscosity can be suppressed due to good compatibility with various acrylate compounds, and there is no risk that the physical properties of the curable material are deteriorated. The (meth)acrylate has one or more structures represented by Formula 1 in the molecule, and when the (meth)acrylate is used for radical curing, the sensitivity is enhanced. In Formula 1, R1 is a hydrogen atom or a methyl group, R2 is a C1-C10 alkyl chain, R3 is either Formula 2 or 3, and R4 is an alkyl chain constituted by carbon atoms and hydrogen atoms.

Abstract: Disclosed is a fluorine-containing oligomer comprising a copolymer of a fluoroalkyl alcohol (meth)acrylic acid derivative of the formula: CnF2n+1(CH2)dOCOCR?CH2 [I], wherein R is a hydrogen atom or a methyl group, n is an integer of 1 to 10, and d is an integer of 1 to 6; and a (meth)acrylic acid derivative of the formula: (CH2?CRCO)mR? [II], wherein R is a hydrogen atom or a methyl group, m is 1, 2, or 3; and when m is 1, R? is —OH group, NH2 group that is unsubstituted or mono- or di-substituted with an alkyl group having 1 to 6 carbon atoms, or a monovalent group derived from an alkylene glycol or polyalkylene glycol group containing an alkylene group having 2 or 3 carbon atoms; when m is 2 or 3, R? is a divalent or trivalent organic group derived from a diol or triol. The copolymerization reaction is performed using a hydrocarbon-based peroxide or azo compound polymerization initiator.

Abstract: The present disclosure provides an ionically crosslinkable composition comprising a (meth)acrylate copolymer component having pendant acid functional groups and pendant photobase functional groups. On exposure to light, the pendant photobase group photolyzes to provide a pendant amine group, that ionically crosslinks the copolymer.

Abstract: Described is a composition comprising: a compound (A) having a substituent (a) being at least either one of an acryloyl group and a methacryloyl group, and a perfluoroalkylene group; and a compound (B) having a substituent (b) being either one of an acryloyl group and a methacryloyl group, and a substituent (c) being either one of an acryloyl group and a methacryloyl group.

Abstract: A copolymer includes a structure unit represented by Chemical Formula I; and a structure unit represented by Chemical Formula II, where R1 and R2 each, independently represent hydrogen atoms or methyl groups, X represents a hydrogen atom or a cation, and L represents an alkylene group having 2 to 18 carbon atoms.

Abstract: The present invention provides a curable composition, which contains a crosslinking aid (B) containing three or more allyl groups in the molecule in an amount of 1 to 50 parts by mass, polyfunctional (meth)acrylic compound (C) in an amount of 5 to 50 parts by mass, and photopolymerization initiator (D1) and/or thermal polymerization initiator (D2) in an amount of 0.1 to 10 parts by mass, respectively, as a polymerization initiator (D) to 100 parts by mass of allyl group-terminated allyl ester oligomer (A); wherein the crosslinking aid (B) containing allyl group is a compound containing three or more allyl groups in a molecule; wherein the content of impurities derived from the crosslinking aid (B) in the curable composition is less than 0.1 mass %; wherein the content of the (meth)acrylic compound containing a hydroxyl group in a molecule (C1) in the curable composition is 0.5 to 30 mass %.

Abstract: Disclosed herein are a donor-acceptor conjugated polymer and an organic electronic device including the same. According to embodiments of the invention, it is possible to realize a conjugated polymer suitable for organic memory devices and a multi-functional, high-performance, large-area organic memory device for electronics including the same, the organic memory device operating in air.

Abstract: A terminal-modified polymer is manufactured by performing a polymerization reaction of a vinyl aromatic monomer, a conjugated diene monomer or both in the presence of an anionic polymerization initiator: and then adding an alkoxy titanium compound thereinto to terminate the polymerization reaction. Alternatively, a terminal-modified polymer can also be manufactured by adding an titanium halide compound instead of the alkoxy titanium compound to terminate the polymerization reaction, and adding for a reaction with a lower alcohol having 1 to 4 carbon atoms. The resulting terminal-modified polymer can improve the dispersibility of silica used as a compounding agent in rubber compositions for automobile pneumatic tires and the like.

Abstract: Polysaccharide alkali swellable rheology modifiers include an emulsion polymer including at least one polysaccharide portion and at least one synthetic portion wherein the at least one synthetic portion is obtained from at least one anionic ethylenically unsaturated monomer, at least one nonionic ethylenically unsaturated monomer or a combination thereof, wherein at least one of the nonionic ethylenically unsaturated monomers is a hydrophobic ethylenically unsaturated monomer, as well as methods of making polysaccharide alkali swellable rheology modifiers.

Abstract: The invention is directed to polysiloxane based block copolymers that comprise siloxane units and units derived from diol compounds comprising at least one pendant oligomeric or polymeric group. The block copolymers according to the invention surprisingly allows any glassware used during its preparation to be washed cleaned with water. The block copolymer can be used in ophthalmic lenses, and may be useful in providing contact lens formulations which are water processable.

Abstract: A method for producing functionalized thermoplastic elastomers on the basis of grafting substrates, selected from olefine-block copolymers of composition 80 to 98 mass-% ethylene-/2 to 20 mass-% C3- to C-12-olefine units or partially crystalline propylene/ethylene and/or C4- to C-12-olefine and/or C4- to C12-diene-copolymers of composition 50 to 98 mass-% propylene-/2 to 50 mass-% C2,- and/or C4- to C12-olefine and/or C4- to C12-diene units or cross-linked styrene/define/styrene or styrene/olefine-block copolymers, wherein, in a liquid mixing reactor per 100 mass parts of particular grafting substrate—0.1 to 15 mass parts of at least one functional monomer from the series of functional groups comprising ?,?-ethylenic unsaturated compounds or 0.1 to 15 mass parts of a monomer mixture comprising at least one of said functional monomers and—0.01 to 10 mass parts of at least one initiator forming free radicals having a 1-hour half-life temperature (THwz/1h) between 50 and 200° C.

Abstract: Provided are cationic comb polymers, obtainable by polymerizing a monomer mixture, which contains at least one monomer having at least one cationic group covalently bonded to the monomer and which contains at least one monomer of the formula R1—O-[AO]n—R2, wherein R1 is an alkenyl group, R2 represents H, an alkyl group having 1 to 20 C atoms, or an aryl group or alkylaryl group having 7 to 20 C atoms, A independently of one another represents a C2 to C6 alkylene group, and n is a value from 2 to 300. Also provided are hydraulically setting cement compositions, shaped bodies, uses, and methods for producing comb polymers. Also provided are novel comb polymers with cationic side chains and structural subunits that comprise polyether components. Further provided are hydraulically setting cement compositions, shaped bodies, uses and methods for producing comb polymers.

Abstract: The present invention provides a modified novolac phenol resin having excellent developability and heat resistance, a method for producing the same, a photosensitive composition, a resist material, and a permanent film. The modified novolac phenol resin has a molecular structure in which hydrogen atoms of phenolic hydroxyl groups possessed by a novolac phenol resin (C) are partially or entirely substituted by acid dissociable groups, the novolac phenol resin (C) being produced by condensing an aromatic compound (A) represented by structural formula (1) below with an aldehyde compound (B).

Abstract: A method of making frothed gel in which no blowing (gas producing) agents are used, and in which non-aqueous gel precursor polyol and additive systems are frothed using a froth mix head, either prior to, or after addition of the isocyonate, depending on desired speed of reaction and cell structure. Isocyanate may be added after the material leaves the froth mix head, in which case it can be added to the froth using a static mixer. No water, or very little water, is used in the process.

Abstract: Provided is a method for producing a molded product comprising preparing a polymerizable composition for optical materials and curing the polymerizable composition for optical materials to produce the molded product. The preparation of the polymerizable composition comprises preparing a polythiol compound containing, as a main component, one kind or two or more kinds selected from a defined group of compounds, and preparing the polymerizable composition from the polythiol compound.

Abstract: Disclosed are methods and compositions for forming a flexible, open cell viscoelastic foams which utilize a thermosetting composition comprising one or more components capable of forming a thermoset matrix and a blowing agent comprising at least one chemical blowing agent, such as water, and at least one physical blowing agent selected from the group consisting of trans-1-chloro-3,3,3-trifluoropropene (HFCO-1233zd(E)), 1,1,1,3,3-pentafluoropropane (HFC-245fa); 1,1,1,3,3-pentafluorobutane (365mfc), blends consisting essentially of at least about 80% of HFC-365mfc and 1,1,1,2,3,3,3-heptafluoropropane (227ea), and combinations of any two or more of these.

Abstract: An epoxide based composition that can be cured at a temperature of less than about 70 C is disclosed. The composition is a liquid at ambient conditions and, therefore, can be used to rehabilitate the interior surfaces of pipelines. The epoxide-based composition comprises at least one epoxide component (component A) and at least one curing agent component (component B) wherein (A) the epoxide component comprises a phenyl glycidyl ether polyepoxide; and (B) the curing agent component comprises a mixture of two salt compounds formed, respectively, from an N-alkanol piperidine and a carboxylic acid bearing 7-12 carbon atoms, and N-cyclohexyl-N,N-dialkyl amine and a carboxylic acid bearing 7-12 carbon atoms.

Abstract: An object of the present invention is to provide a novel curing agent or a curing accelerator for epoxy resin. The curing agent or a curing accelerator for epoxy resin of the present invention is a clathrate compound comprising the following (a1) and (a2): (a1) a tetrakis(hydroxyphenyl)ethane compound or a carboxylic acid compound represented by formula: A(COOH)k wherein, A represents a C1-C6 linear hydrocarbon group optionally having a substituent, a C3-C10 monocyclic hydrocarbon group optionally having a substituent, or a C6-C10 bicyclic hydrocarbon group optionally having a substituent, and k represents 2 or 3; and (a2) a xylylene diamine compound.

Abstract: The present invention relates to in-mold coating of a cyclic olefin polymer. More particularly, the present invention relates to methods and compositions for in-mold coating cyclic olefin polymers prepared by ring opening metathesis polymerization (ROMP) reactions and the manufacture of polymer articles via ROMP. Polymer products produced via the metathesis reactions of the invention may be utilized for a wide range of materials and composite applications. The invention has utility in the fields of polymer and material chemistry and manufacture.

Abstract: A polymer colorant including polymer monomer units, and at least one alizarin unit which is incorporated into the polymer and which provides color to the polymer colorant and a process for preparing the polymer colorant. An article or composition containing the polymer colorant. A toner including the polymer colorant, and optionally, one or more ingredients selected from the group consisting of crystalline polyester resins, amorphous polyester resins, colorants, waxes, coagulants, mordants, and mixtures and combinations thereof. A polymer latex including an aqueous dispersion of polymer colorant, wherein the polymer colorant comprises polymer monomer units and at least one alizarin unit which is incorporated into the polymer and which provides color to the polymer colorant; and optionally, a mordant.

Abstract: A process for making a starch-resin copolymer is described, the process comprising: mixing at least one of a dicarboxylic acid and a dicarboxylic acid anhydride with a starch to yield a starch mixture; adding a liquid mixture including water and a polyol to the starch mixture to produce a functionalized starch; and mixing the functionalized starch with a resin to produce the starch-resin copolymer, wherein the starch used in the process has a low moisture content in comparison with the moisture content of starch used in current processes. Starch-resin copolymers produced by the present process can be biodegradable and compostable.

Abstract: An oxygen-absorbing resin composition containing a polyester compound and a transition metal catalyst, wherein the polyester compound has at least one constituent unit having a tetralin ring selected from the group consisting of constituent units represented by general formulas (1) to (4) and wherein the polyester compound is a polyester compound having a tetralin ring obtained by synthesis using a zinc compound.

Abstract: A process to prepare a cyclic polyester oligomer composition comprising a cyclic polyester oligomer having furanic units is disclosed. The process comprises the step of reacting a monomer component in the presence of an optional catalyst and/or optional organic base in a ring closing oligomerization step under conditions of a reaction temperature and reaction time sufficient to yield a cyclic polyester oligomer having furanic units. The invention further relates to a cyclic polyester oligomer composition obtainable by said process, wherein the cyclic polyester oligomer composition comprises a cyclic polyester oligomer of structure Y1 or Y2 having furanic units, wherein the composition contains less than 5%, preferably 3, most preferably 1 weight % of linear oligomeric polyester species in the composition. The present invention further relates also to the use of said cyclic polyester oligomer composition in the production of a polyester polymer.

Abstract: A process for preparing a polyoxazoline includes feeding continuously an oxazoline, a solvent, and a catalyst to a continuous stirred tank reactor at a rate which provides for a residence time sufficient to achieve ring opening of the oxazoline and polymerize the oxazoline; exiting a polyoxazoline solution from the continuous stirred reactor, the polyoxazoline solution including polyoxazoline, solvent, and, optionally, unreacted oxazoline, low molecular weight oligomeric oxazoline, or a mixture thereof; removing the solvent, and, optionally, unreacted oxazoline, low molecular weight oligomeric oxazoline, or a mixture thereof from the polyoxazoline solution; and recovering the polyoxazoline.

Abstract: A resin according to the present invention is prepared by reacting a reaction product, which is obtained by Michael addition reaction between the following component (A) and the following component (B) and a subsequent amide group formation reaction, with the following component (C): (A) an aliphatic diamine having 2 to 8 carbon atoms or a diamine having a C6-8 aromatic ring; (B) an unsaturated carboxylic acid represented by formula (2) and/or a derivative thereof, provided that the following component (C) is excluded: [in formula (2), R1 and R2 independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an aralkyl group having 1 to 8 carbon atoms or an aryl group]; and (C) a (meth)acrylic acid-type compound having at least one glycidyl or isocyanate group.

Abstract: An alkoxylated (poly)amine polymer prepared from an alkoxylated (poly)amine and an ethylenically unsaturated monomer containing a free radical polymerizable double bond, as well as formulations, such as personal care formulations, including the alkoxylated (poly)amine polymers.

Abstract: The invention relates to polyisocyanates comprising urethane groups, based on toluylene diisocyanate, to a method for their production, and to their use as the polyisocyanate component in one- and two-component polyurethane coatings.

Abstract: A disulfide-linked covalent organic polymer and a preparation method thereof are described, and more particularly a disulfide-linked covalent organic polymer prepared by a disulfide formation reaction, a preparation method thereof, and the use of the organic polymer as an organic solvent absorbent. A disulfide-linked covalent organic polymer prepared according to the disclosure may be used as an absorbent capable of selectively absorbing various organic solvents in aqueous solutions or wastewater.

Abstract: The present invention relates to silicone polymer ligands for binding to quantum dots. The silicone polymer ligands contain a multiplicity of amine, carboxy, and/or phosphine binding groups suitable for attachment to quantum dots. The present invention also describes a process for the preparation of quantum dot binding ligands.