Abstract: Manifolds suitable for use in hemodialysis, hemofiltration, hemodiafiltration, and peritoneal dialysis are provided. One or more of the manifolds can include a manifold body and an external tube. The manifold body can include at least one conduit including a first conduit and at least one port including a first port in fluid communication with the first conduit. The external tube can be in fluid communication with the first port and can include a main segment, a first branch segment, and a second branch segment containing at least one bacterial filter. The first branch segment and/or second branch segment can include at least one flow restrictor. Dialysis machines, systems, and kits including one or more such manifold are also provided, as are methods of performing hemodiafiltration using such manifolds.

Abstract: A method is provided for controlling the return phase of a blood separation procedure having a draw phase in which blood is drawn through an access or donor line, is separated, and a fluid, such as a cellular concentrate, is flowed into a reservoir, and a return phase in which fluid is flowed from the reservoir through the donor line. The method comprises flowing fluid from the reservoir through the donor line in a steady state return; monitoring the donor line for the presence of air; and, upon detecting air in the donor line, determining the amount of fluid remaining in the reservoir. Then, either i) the donor line is purged, if the amount of fluid remaining in the reservoir exceeds a predetermined amount, and the steady state return of fluid from the reservoir through the donor line is resumed; or ii) if the amount of fluid remaining in the reservoir does not exceed the predetermined amount, the return phase is ended by terminating the flow of fluid from the reservoir through the donor line.

Abstract: A microenvironment of a biological body is controlled, and more particularly, is measured, changed, and monitored with respect to temperature, pH level, moisture and other tissue parameters of a region of the body while, optionally, administering a therapeutic agent to that region.

Abstract: A purgative product is provided which includes a gelatinous purgative and a dispenser for dispensing the gelatinous purgative. The dispenser includes a container with an open end and an opening on the opposite end. A plunger and sealing element can be inserted into the container, such that when the plunger is pushed towards the opening in the container, the gelatinous purgative between the sealing element and the opening of the container is pushed towards and out of the opening for ingestion by a user.

Abstract: A medical imaging facility that has a signal detection unit with a patient accommodation area that accommodates a patient for a medical imaging investigation. The patient accommodation area is at least partially surrounded by the signal detection unit, and the medical imaging facility has a contrast agent injector that is integrated within the medical imaging facility.

Abstract: Systems and methods are provided for a drug delivery device and use of the device for drug delivery. In various aspects, the drug delivery device combines a “solid drug in reservoir” (SDR) system with an electrolytic pump. In various aspects an improved electrolytic pump is provided including, in particular, an improved electrolytic pump for use with a drug delivery device, for example an implantable drug delivery device. A catalytic reformer can be incorporated in a periodically pulsed electrolytic pump to provide stable pumping performance and reduced actuation cycle.

Abstract: Ambulatory infusion pumps, durable assemblies, and disposable assemblies, including energy sources, reservoirs, baseplates, and related components therefor, as well as component combinations and related methods.

Abstract: The disclosed subject matter relates to a valve device that includes a valve member located within a housing in which the valve member's operation can be bypassed. For example, the valve device can include a bypass device that has an input structure, a motion conversion structure, and an output structure. The input structure can include a portion configured to resiliently deform if a valve opening input force is applied to the input structure in an input direction. The motion conversion structure can be configured to convert the valve opening input force into motion of the output structure in an output direction that is non-parallel to the input direction. The output structure can be configured to move the valve member (e.g., from a closed state to an opened state in order to bypass normal valve operation) if the motion conversion structure is displaced in the input direction. The valve device can be used in various manners, and is particularly suitable for use in a patient fluid delivery system.

Abstract: A medical device includes an antenna external to a case, package, or encapsulant for the electronic systems of the medical device. In one embodiment, a diabetes infusion pump is enclosed within a metal case, the pump including a processor and a communication module for wireless communications. An antenna is disposed in the delivery tubing of the pump outside the case with an antenna feed interconnecting the external antenna with the internal communication module. In another aspect, a thin film antenna is formed on the outer surface of the case in which a physiological parameter sensor, such as a glucose sensor, is enclosed. Multiple antennas may be used for communications on different frequencies.

Abstract: In a method for controlling the administration of insulin to a patient (P) a target glucose level (T) is set and a controller (10) computes a recommended infusion rate (R) based on the target glucose level (T) and a measured glucose level (G) of a patient (P) for administering insulin to the patient (P). The controller (10) comprises a controller gain (K) for computing the recommended infusion rate (R). Herein, an insulin sensitivity (IS) of the patient (P) is determined by means of a mathematical model taking into account the measured glucose level (G) and an actual infusion rate (IR) of insulin administered to the patient (P) and, based on the insulin sensitivity (IS), the controller gain (K) of the controller (10) is determined. In this way a method for controlling the administration of insulin to a patient is provided which in a reliable, computationally efficient manner allows for maintaining a patient's blood glucose level at or around a desired target glucose level.

Abstract: A method for treating a disorder using an automatic injection device is disclosed. The device includes a syringe movably disposed in a housing and including a barrel portion, a needle and a bung for sealing the barrel portion. The device includes a syringe actuation component for moving the syringe towards a first open end of the housing such that the needle projects from the first end, and for subsequently applying pressure to the bung. The syringe actuation component includes a pressurizer, a rod comprising a compressible portion projecting therefrom, and a flange between a second end of the rod and the compressible portion. The device also includes a biasing mechanism for biasing the syringe actuation component towards the first open end of the housing, the biasing mechanism disposed about the second end of the rod between the flange and a second end of the housing.

Abstract: The present disclosure relates to a needleless syringe and method for delivering therapeutic particles. A source of therapeutic particles is located between a gas source and a cannon having a side opening. Gas released from the gas source causes a propagation of the therapeutic particles through the cannon. The side opening causes a reduction of a pressure of the gas in the cannon.

Abstract: Finger control handles for conventional syringes are disclosed. The finger control handles may be configured to be assembled with a hand-held syringe, to be secured in place on a proximal portion of the barrel of the syringe and, when secured in place, to rotate freely about a circumference of the proximal portion of the barrel of the syringe. Systems that include the finger control handles and a hand-held syringe that is configured to capture the finger control handles are also disclosed, as are various methods of use, including methods for assembling the finger control handles with the syringe and methods for connecting the syringe to an elongated medical instrument, such as a catheter.

Abstract: The present invention relates to a medicament delivery device comprising a drive means configured to act on a medicament container for expelling a medicament; a holding means configured to hold said drive means in a pre-tensioned state; an activation means configured to interact with said holding means for releasing said drive means from the pre-tensioned state; wherein the device further comprises feedback means configured to interact both with said holding means and with said drive means for generating an audible and/or tactile and/or visual signal indicating that the medicament has been completely expelled.

Abstract: A syringe includes a gasket, a barrel, and a plunger. The plunger includes a helical rib provided on an outer surface of a head portion, and the gasket comprises a helical valley portion for threadedly engaging with the helical rib, a plunger-retaining annular rib, and an accommodation portion for a part of the plunger at which the helical rib is formed. The annular rib comprises a rib absent portion for guiding, to the accommodation portion, the helical rib reaching the annular rib as threaded engagement is advanced between the plunger and the gasket. The helical rib comprises an entrance-restricting terminal end portion for restricting the entrance of the helical rib into the rib absent portion after the part of the plunger 4 at which the helical rib is formed is stored in the accommodation portion 32 of the gasket.

Abstract: A drug delivery device has a cartridge holder adapted to receive and hold a cartridge, the cartridge holder having a receiving and a holding state. The device further comprises a drive assembly with a piston rod and a drive spring, setting means allowing a user to set a dose amount to be expelled and strain the drive spring correspondingly, and user actuated release means for releasing the drive spring, wherein the drive assembly spring cannot be released to move the piston rod unless the cartridge holder is in the holding state.

Abstract: Drug delivery device adapted to receive a cartridge and comprising a housing, a front-loaded cartridge holder adapted to receive and hold a cartridge in a loaded position, and stop means adapted to engage a proximal surface of a received cartridge The stop means is actuatable between a receiving state in which the stop means is positioned in a first axial position thereby defining how far proximally a received cartridge can be inserted, and an operational state in which the stop means allows an inserted cartridge to be moved axially to a second more proximal position.

Abstract: A multiple dose syringe has a first valve defining a first valve opening pressure and a second valve defining a second valve opening pressure. A storage chamber in fluid communication with the second valve stores multiple doses of a substance therein and includes an outlet for dispensing multiple doses of the stored substance therethrough. A compression surface is movable between first and second positions and defines a compression chamber between the compression surface and the first valve. Movement of the compression surface in a direction from the first position toward the second position dispenses substance in the compression chamber through the first valve and out of the syringe. Movement of the compression surface in a direction from the second position toward the first position causes substance to flow from the storage chamber through the second valve and into the compression chamber.

Abstract: A device configured to administer a medication can comprise a lower housing that includes a housing latch. The device can further comprise a needle guard that is movable relative to the lower housing along a first direction from a first position to a second position so as to expose a needle, and an upper housing supported relative to the lower housing. The upper housing can be configured to move with respect to the lower housing along a second direction from a pre-use position to a dispensed position. The housing latch can releasably interfere with the upper housing when the upper housing is in the pre-use position so as to prevent the upper housing from moving toward the dispensed position, and the movement of the needle guard toward the second position, causes the interference to be removed, thereby allowing the upper housing to move toward the second position.

Abstract: Systems and methods are provided for processing a fluid and then returning processed fluid and/or replacement fluid to a fluid recipient. The returning fluid is monitored to detect air therein and, if air is detected, steps are taken to automatically purge the air from the returning fluid without requiring the intervention of a system operator. The system may respond to detected air by pumping the processed fluid and/or replacement fluid away from the fluid recipient and into a processed fluid reservoir, where the air is purged from the processed fluid and/or replacement fluid. Thereafter, the weight of the processed fluid reservoir may be checked to confirm that sufficient fluid has been pumped back into the reservoir to remove the air. After it has been confirmed that the air has been purged from the fluid, the system may resume pumping the fluid toward the fluid recipient.

Abstract: Systems for managing pressure in a fluid reservoir chamber of a fluid infusion device are provided. For example, a fluid infusion device comprises a housing having a chamber for receiving a fluid reservoir. The fluid infusion device also comprises a drive system contained within the housing. A portion of the drive system is movable for dispensing fluid from the fluid reservoir. The fluid infusion device comprises a pressure management system at least partially defined in the portion of the drive system to vent air from the chamber.

Abstract: Systems for managing pressure in a fluid reservoir chamber of a fluid infusion device are provided. For example, a fluid infusion device is provided. The fluid infusion device comprises a housing defining a reservoir chamber for receiving a fluid reservoir. The fluid infusion device also comprises a drive system contained within the housing for dispensing fluid from the fluid reservoir. The fluid infusion device comprises a pressure management system at least partially defined in the reservoir chamber to manage air pressure in the reservoir chamber.

Abstract: A substance delivery module (4) and apparatus (2) for delivering substance in aerosol form are disclosed. The substance delivery module (4) comprises a plurality of substance containers (90) and a plurality of pistons (76), with each substance container (90) being mounted in the module for cooperation with a dedicated piston (76). Another substance delivery module (4) is disclosed comprising a piston (76) defining a delivery axis (150) and a substance container (90), moveably mounted with respect to the piston (76). The substance container (90) is moveable along the delivery axis (150) and may for example be moved towards and onto the piston (76). Either of the substance delivery modules (4) may be assembled with an aerosol generator (10) and an aerosol delivery conduit (14) in fluid communication with the aerosol generator (10) to form an apparatus (2) for delivering substance in aerosol form. The apparatus (2) may further comprise a control module (6).

Abstract: A vapor inhalation device (10) comprising: a housing (12) adapted to enable a user to inhale vapor, simulating the effects of smoking, the housing being adapted to receive a cartridge (14) for containing liquids; the cartridge (14) comprising or connected to a first release device (15a) arranged to vaporize and release a first liquid (A) comprising a first substance (a) from a first reservoir (16a) into the housing (12); and to a second release device (15b) arranged to vaporize and release a second liquid (B) from a second reservoir (16b), wherein the housing (12) is adapted to mix the vaporized first (A) and second liquids (B) such that the user can inhale vapor containing the first substance (a) of a particular amount; a communication unit (17) configured to receive and transmit data for controlling the inhalation device (10); a controller (18) configured to communicate with the communication unit (17) and to receive data from the communication unit; and to determine an amount of first substance (a) to

Abstract: The present disclosure pertains to a pressure support system (10) configured to deliver a pressurized flow of breathable gas to the airway of a subject (12), the pressure support system comprising: a pressure generator (14) configured to generate the pressurized flow of breathable gas; one or more sensors (18) configured to generate output signals conveying information related to whether the subject is ready to receive breath stacking therapy; and one or more processors (20) configured to execute computer program modules, the computer program modules comprising:—a control module (52) configured to control the pressure generator to generate the pressurized flow of breathable gas according to a pressure control therapy regime,—an event module (54) configured to determine breath stacking events responsive to the output signals indicating that the subject is ready to receive breath stacking therapy, and—a breath stacking module (56) configured to, responsive to the determination of a breath stacking event, contro

Abstract: A device for maintaining a water level in a respiratory humidification system, said device comprising: at least one sensor positioned external to a humidification component, the at least one sensor configured for sensing water related information in the humidification component and providing the water related information to a water control module, the water related information comprising data configured for being used to control an operation of the water control module.

Abstract: Anxiety attacks can often be limited or eliminated by reducing the concentration of inhaled carbon dioxide. Disclosed is a handheld device for reducing the carbon dioxide concentration of inhaled air by using stacked sheets having rows of adsorbents deposited thereon and which form a removable cartridge. The cartridge is placed into an adsorbent cartridge cradle to secure the cartridge within the device housing and to maintain ventilation channels through the cartridge. Inhaled air passes through the adsorbent containing cartridge and exhaled air exits the device through a bypass to avoid poisoning the adsorbent with exhaled carbon dioxide.

Abstract: A catheter guide device configured to facilitate precise placement of a downstream end of a catheter within a patient. The catheter guide device comprises a torque assembly configured to frictionally engage an exterior surface of a catheter and a hub configured to engage a catheter sheath and thereby prevent rotation of the catheter sheath relative to the hub. The torque assembly is rotatably secured to the hub such that rotating the torque assembly relative to the hub rotates the catheter relative to the catheter sheath and thereby moves the downstream end of the catheter within the patient. The hub additionally comprises a detent mechanism configured to engage a plurality of gear teeth on an exterior surface of the torque assembly to thereby impede unintended rotation of the torque assembly relative to the hub.

Abstract: A catheter assembly includes an inner needle; a catheter through which the inner needle extends; and a catheter hub retaining the catheter; a needle cover that accommodates the inner needle when the inner needle is withdrawn from the catheter, the needle cover including: an inner tube attached to and detached from a catheter hub, the inner tube including a stopper portion, and an outer tube covering a portion of the inner tube, and moving relative to the inner tube when the inner needle is withdrawn. The stopper portion prevents relative movement between the inner tube and the outer tube in a standby position proximate to a radially outer side of the inner tube, while the inner needle extends through the catheter. The stopper portion slides to a blocking position accompanying relative movement of the outer tube with respect to the inner tube when the inner needle is withdrawn.

Abstract: A guide wire includes (1) a core shaft, (2) a coil body covering a distal end portion of the core shaft and having spirally wound multiple element wires, and (3) a distal end fixed portion by which a distal end of the core shaft is fixed to a distal end of the coil body. The distal end of the coil body includes (i) a fixed portion in which adjacent ones of the multiple element wires are fixed to each other and (ii) a gap portion in which adjacent ones of the multiple element wires are not fixed to each other to provide a gap between the adjacent ones of the multiple element wires in the gap portion, as viewed in a cross section that is perpendicular to a longitudinal axis of the guide wire. The distal end fixed portion enters into the gap portion.

Abstract: A wire guide for feeding a medical catheter through the body passage of a patient to a distant target site within the body has a variably flexible distal portion. The distal portion facilitates threading the guidewire in a tortuous path through acute bends at branch junctions in the body passages of the patient. The wire guide end is able to feed into very delicate vessels such as ventricles of the brain and the spinal canal without puncturing the wall or damaging organs.

Abstract: A dilator for sheathless access to a vessel of a patient, having a distal portion with a maximal outer diameter that extends from a distal end to a guidewire exit port and a proximal portion with a reduced profile that extends from the guidewire exit port to the proximal end and a lumen that extends between the distal end and the guidewire exit port. A first guidewire may be positioned within the vessel and the dilator advanced over the guidewire. A guide catheter may then be advanced over the dilator.

Abstract: An expandable medical balloon, the expandable medical balloon comprising a first balloon wall, the first balloon wall comprising a first balloon layer of polyethylene terephthalate having a first intrinsic viscosity, the first layer is outer to a second layer of polyethylene terephthalate, the second balloon layer of polyethylene terephthalate having a second intrinsic viscosity, the second layer is an inner layer, wherein the intrinsic viscosity of the first balloon layer is higher than the intrinsic viscosity of the second balloon layer by about 0.05 dl/g or more.

Abstract: Angioplasty or valvuloplasty balloon catheters with a ripcord for cutting, ripping, or tearing a balloon can achieve faster deflation times. Methods using such catheters can improve patient outcomes in percutaneous transluminal valvuloplasty and angioplasty.

Abstract: Systems and methods are provided for optically reading a setting of an implantable valve. The valve includes optical emitters that are wirelessly powered by a valve reading tool that images the emitted light to determine the valve setting.

Abstract: A method of using a catheter assembly for inserting in a fluid filled space in a body includes providing a main body having a first end portion and a second end portion. The first end portion is positioned within the fluid filled space. The second end portion is adjusted to extend outwardly from the fluid filled space when the first end portion is positioned within the fluid filled space. A catheter tip is connected to the second end portion of the main body. The catheter tip includes a housing having a cavity defined therein and a rotating element positioned within the fluid filled space. The rotating element is rotated within the cavity of the housing to impart movement of the first end portion of the main body within the fluid filled space.

Abstract: An implantable catheter or shunt for draining fluid from a body cavity. The catheter or shunt body has a wall structure that carries one or more therapeutic agents in a manner enabling release of the therapeutic agent from the wall structure in situ after surgical implantation of the catheter or shunt body. The therapeutic agent can be gradually released over time to prevent infection, inhibit tissue ingrowths, and/or provide some other desired medicinal purpose. As an example, the therapeutic agent can be rapamycin or an mTOR inhibitor. According to some contemplated embodiments of the present invention, the therapeutic agent carried by the catheter/shunt is rechargeable or refillable in situ so that the therapeutic agent can be gradually released from the catheter/shunt over the expected useful life of the catheter/shunt.

Abstract: A urethral stricture treatment apparatus and treatment method are disclosed, which can easily inhibit the position of a medical material from deviating from a treatment site and can make the medical material selectively indwell different treatment sites. The urethral stricture treatment apparatus can have a dilation portion, which dilates in a state of holding a medical material providing an epithelial function so as to bring the medical material into contact with an inner wall of urethra, and a restriction portion which is provided in a position closer to a distal side than the dilation portion in an insertion direction such that a distance between the restriction portion and the dilation portion can be relative changed, and comes into contact with external urethral sphincter in a living body so as to restrict the movement of the medical material toward the distal side.

Abstract: A dilator for dilating the tissue of a corpora cavernosum of a penis. The dilator includes a handle, a stem and an intermediate portion connecting the handle and the stem. A dilation portion includes an exterior surface defining a groove configured to leave at least one section or segment of the tissue in the corpora cavernosum undisturbed and un-dilated. A kit of parts including a dilator and a penile prosthetic insert is also disclosed.

Abstract: Disclosed in some examples are methods, machine readable mediums, and systems for automatic activation of pharmaceutical agents using wearable devices in response to detecting one or more contexts of the user which indicate the need for pharmaceuticals. In some examples, a wearable device may emit signals to automatically release or activate drugs that are already in a user in response to a particular context of the user. For example, if the user begins vigorous exercise, the system may activate a pain medication that was already previously ingested by the user to alleviate anticipated joint pain.

Abstract: The appliance includes an appliance body/handle and an interface assembly for receiving a detachable workpiece. The body/handle includes a signal-generating assembly with electrical connections to the appliance body interface. The signal-generating assembly is controlled by a microprocessor, which generates signals adapted to control and operate the workpiece which is attached to the appliance. A plurality of workpieces are included which are individually adapted for treating various spot skin irregularities. The appliance further includes a system for identifying the workpiece attached, so that appropriate operating signals can be generated and provided to the attached workpiece.

Abstract: A device for dispensing a topically administered drug has a spreader which is used to actuate a pump to release the drug and then to spread the drug on the skin and. The spreader is coupled to a lock that prevents it from actuating the pump after a number of drug doses have been dispensed. The pump can be actuated to release no more than the selected quantity of drug per day or actuation.

Abstract: A micro-needle roller (MNR) infusion system for transdermal delivery of active agents, skin-care products, and other topical formulations is described herein. The infusion system of the instant invention comprises a needle roller assembly with needles enclosed in a housing with a vacuum line and a disposable cartridge having the active agent, the skin-care product or the topical formulation. The vacuum delivers the fluid and ensures that the skin is being pulled against the needle wheel surface to ensure that penetration of the needles is complete into the skin, simultaneously the fluid is flowing to the wheel and to skin as it rolls along with the outer housing of the tip cap assembly being occluded to the skin surface.

Abstract: A medical tubing connector includes a first connector portion configured for connecting to a mating second connector. A tube engagement portion is integral with and opposite the first connector portion and configured for connecting to a medical tube. A liquid passage extends through the first connector portion and the tube engagement portion. The first connector portion includes a continuous outer surface for sealing engagement with the mating second connector. An annular portion is integral with and surrounds the male connector portion. A connecting portion connects the first connector portion to the annular portion. The connecting portion is discontinuous permitting liquid to pass through the connecting portion so that liquid is prevented from pooling between the first connector portion and the annular portion.

Abstract: A connector device for a fluid system for medical purposes is disclosed that includes a main housing having a fluid flow chamber forming two channel portions leading in different directions towards two open attachments, wherein the attachments are provided for connection to a fluid line or a fluid reservoir, and also with an attachment port which opens into the fluid flow chamber and which has a closure arrangement and which includes a Luer connecting portion. The fluid flow chamber has a dimensionally stable flow-guiding wall which is arranged between the two channel portions in the fluid flow chamber and protrudes freely with a front edge towards the attachment port in such a way that the closure arrangement, upon opening of the closure arrangement, interacts with the front edge of the flow-guiding wall in order to effect a flow of fluid out of the attachment port into only one channel portion.

Abstract: A medical device cap that protectively surrounds a medical device component for disinfection purposes and includes an identification element that can record and transmit pertinent information of the medical device cap and the medical device component is disclosed. The medical device cap enables documentation of instances when the cap is used and promotes stronger compliance with the use of medical device caps for applications involving disinfection of a medical device component such as an IV access port or a luer tip. Use of the medical device cap results in better compliance and monitoring of the use of such caps and leads to reduced incidence of CRBSI infections related to medical device component contamination. In one embodiment, the medical device cap enables automated real-time electronic documentation of when the cap is applied, while also documenting duration of application and tracking of device for inventory management.

Abstract: In a method, an electrode lead is provided that includes a tubular lead body, an electrode supported by the lead body, a rotatable member, a deployable member and a deployment mechanism. The rotatable member is contained within a distal end of the tubular lead body. The deployable member is attached to the rotatable member and comprises a tissue anchor that includes mesh. Also in the method, the distal end of the tubular lead body is positioned proximate target tissue of a patient. The rotatable member is rotated relative to the tubular lead body. The deployable member is driven along the central axis, out the distal end of the tubular lead body, and into the target tissue using the deployment mechanism responsive to the rotation of the rotatable member. The deployment member does not rotate about the central axis with the rotation of the rotatable member.

Abstract: A lead for deep brain stimulation includes a first electrode group and a second electrode group. The first electrode group includes at least one first electrode which is adapted for being positioned in a nucleus accumben of a brain. The second electrode group includes at least one second electrode which is adapted for being positioned in an anterior limb of an internal capsule of the brain. With one single lead implanted in the brain, the first electrode group and the second electrode group simultaneously stimulating the nucleus accumben and the anterior limb of the internal capsule, and the present disclosure improves the effect and safety of DBS in the therapy of drug-addiction, OCD and/or depression.

Abstract: Various examples are directed to systems and methods comprising receiving a control signal at a control circuit of a surgical device. The control circuit may comprise a first circuit portion coupled to at least one switch operable between an open state and a closed state. The first circuit portion may be configured to communicate with a surgical generator over a conductor pair to receive the control signal and may comprise at least one resistor coupled to the at least one switch. Methods may also comprise determining the state of the at least one switch based on the value of the resistor.

Abstract: Cosmetic facial treatment delivery system with skincare benefit agents and iontophoresis micro-current zones are provided for delivering skincare treatments to multiple targeted areas of the skin to treat different concerns of an individual user. The system includes a sheet substrate with skincare agents and a dual-phase cream that generates micro-current when activated. A first phase contains a reduction agent and a second phase contains an oxidation agent. The cream is activated to produce micro-current when the two phases are combined. The cream is applied to skin along with the sheet substrate. The micro-current generated facilitates delivery of skin benefit agents from the sheet by iontophoresis, or directly affects treatment by delivery of iontophoresis micro-current to the skin.