Abstract: An apparatus for measuring a concentration of amyloid-beta within a sample includes signal generation circuitry and a detector. The signal generation circuitry generates a first signal having an applied first orbital angular momentum signature and applies the first signal to the sample. The detector receives the first signal after it passes through the sample and determines the concentration of the amyloid-beta within the sample based on a detected second orbital angular momentum signature within the first signal received from the sample. The detector provides an output of the determined concentration as an indication for determining an early onset of Alzheimer's.

Abstract: Methods, kits and compounds are provided that relate to the diagnosis, treatment, and/or prevention of preeclampsia.

Abstract: Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.

Abstract: The present invention relates to an in vitro method for the detection of an anti-drug antibody (ADA) against a therapeutic drug antibody (TDA) in a biological sample. The in vitro method comprises detecting and capturing said ADA using affinity moieties obtained from an intact therapeutic drug antibody, or a Fab fragment thereof, in a certain manner. Avoiding using only intact therapeutic drug antibodies or only Fab fragments thereof as reagents in such a method has been proven as an efficient way of increasing sensitivity, decreasing unspecific binding and the formation of large protein complexes. Such a method has great utility in therapeutic drug development or in the evaluation of a particular treatment of a patient.

Abstract: A method for aiding in categorising or determining prognosis in a subject with COPD, or in selecting a therapeutic strategy for a subject with COPD, or in monitoring disease progression or assessing effectiveness of a treatment regime for COPD, the method comprising the step of assessing the antibody response to carbonylated vimentin in a sample obtained from the subject. The method may further comprise the step of selecting a treatment regime making use of the information on the antibody response to carbonylated vimentin in the sample. The step of assessing of the antibody response to carbonylated vimentin may comprise the step of determining the ratio of IgG to IgM in the antibody response to carbonylated vimentin.

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Heat shock protein beta-1, WAP four-disulfide core domain protein 2, Choriogonadotropin subunit beta, Placenta growth factor, and Mitochondrial 60 kDa heat shock protein as diagnostic and prognostic biomarkers in renal injuries.

Abstract: The present invention relates to methods for the diagnosis of subjects that have or are at risk of having Alzheimer's disease (AD). In particular the present invention identifies individuals who have or are at risk of having AD through measurement of the levels of Afamin in combination with at least one other biomarker such as Alpha-1-antichymotrypsin, Alpha-2-macroglobulin, ApoB100, Complement C5, Serine threonine protein kinase TBK1 or Complement C3 in a fluid sample taken from a subject. Furthermore, genotype (Apolipoprotein E or glutathione S-transferase Omega) may also be taken into consideration and used within classification algorithms to determine the probability of a subject having or being at risk of having AD.

Abstract: Subject matter of the present invention is a method for stratifying a female subject for hormone replacement therapy wherein the level of Pro-Neurotensin or fragments thereof is determined and the level of Pro-Enkephalin or fragments thereof is determined.

Abstract: CSF diagnostic in vitro method for the diagnosis of dementias and neuroinflammatory diseases, in which a determination of the procalcitonin immunoreactivity (PCT immunoreactivity) is carried out in a sample of cerebrospinal fluid (C SF) of a patient who is suffering from a dementia or neuroinflammatory disease or is suspected of suffering from such a disease. Conclusions about the presence, the course, the severity or the success of a treatment of the dementia or neuroinflammatory disease are drawn from a measured PCT immunoreactivity which is above a threshold value typical for healthy individuals.

Abstract: The current invention provides an improved immunoassay for the detection and determination of pyrrolidinophenone based designer drugs in hair and biological fluids (urine, blood, and oral fluid). The generic immunoassay is underpinned by novel, sub-family-specific antibodies, which display surprising sensitivity. The invention further describes substrates comprising an antibody that is specific to compounds of the pyrrolidinophenone family. Also described are the novel immunogens from which the antibodies are derived and kits incorporating the antibodies of the current invention.

Abstract: The present invention relates to antibodies for use in detecting polymyxins and tracers; and to a single-capture immunodetection method and kits, each utilising the antibodies of the invention, and disclosed tracers.

Abstract: A method for determining a physical property of a biological sample. The method comprises the steps of: acquiring a set of preliminary calibration signals of a first lot of a reagent using an automatic analyzer with a first photometry module; acquiring a reference set of signals of the first lot of the reagent using a calibration analyzer with a second photometry module; determining a set of module specific components by subtracting the reference set of signals from the preliminary calibration signals; acquiring a lot specific set of signals of a second lot of the reagent using the second photometry module; determining a lot calibration for the first photometry module using the set of module specific components and the lot specific set of signals; acquiring a measurement signal of the biological sample using the first photometry module and the second lot of the reagent; and determining a physical property of the biological sample using the measurement signal and the lot calibration.

Abstract: A module for a laboratory sample distribution system, a laboratory sample distribution system comprising such modules, and a laboratory automation system comprising such a laboratory sample distribution system are presented. A magnetic coupling enhancer is provided in order to increase magnetic coupling between adjacent modules.

Abstract: Provided are a smart band, a motion state determining method of the smart band, and a computer-readable recording medium including a program for performing the same. The smart band includes: a motion sensor that detects a user's motion and creates motion data; a memory that stores a normal motion score of a user; and a control unit that determines scores of first to third factors, which are standards for determining a user's motion state, on the basis of the created motion data, calculates a final score on the basis of the determined scores of the first to third factors, and determines the user's motion state by comparing the normal motion score with the final score.

Abstract: A technique for automatically determining direction of motion of a pedestrian is described. In embodiments, accelerometer measurements obtained from an accelerometer of a mobile device are converted from a mobile device reference frame to a local level reference frame. The local level accelerometer measurements are filtered to obtain a first series of frequency components representing acceleration at an estimated stride frequency of the pedestrian in a first direction and a second series of frequency components representing acceleration at the estimated stride frequency of the pedestrian in a second direction that is orthogonal to the first direction. A heading angle of a major axis or semi-major axis of an ellipse defined at least by one or more frequency components in the first series and one or more frequency components in the second series is then determined The direction of motion of the pedestrian is determined based on the heading angle.

Abstract: A microelectromechanical-systems (MEMS) device includes a driven mass and has a natural stiffness or damping. An actuator applies force to the mass, movement of which is measured by a sensing capacitor. A control circuit operates the actuator per displacement or velocity of the driven mass, so that a characteristic stiffness or damping of the mechanical subsystem is different from the respective natural value. A method of transforming a MEMS device design includes determining an aim performance value of the design and a baseline performance uncertainty of the design, selecting candidate sets of parameter values, determining a candidate, first, and second performance value for each, scoring the candidates, and repeating until one of the candidates satisfies a termination criterion, so the transformed design using that candidate set has the aim performance value and the respective first and second performance values closer to each other than the baseline performance uncertainty.

Abstract: According to one example, a system includes a flexural beam having a first face and a second face opposite the first face and a first coil of optical fiber coupled to the first face, where the first coil of optical fiber is encapsulated by a cured encapsulation composition, wherein the encapsulation composition has a viscosity from 30 to 300 millipascal-second at 25° C.

Abstract: In some exemplary embodiments, a MEMS accelerometer includes a device wafer having a proof mass and a plurality of tracking anchor points attached to a substrate. Each tracking anchor is configured to deflect in response to asymmetrical deformation in the substrate, and transfer mechanical forces generated in response to the deflection to tilt the proof mass in a direction of the deformation.

Abstract: A microelectromechanical systems (MEMS) device, such as a three-axis MEMS device can sense acceleration in three orthogonal axes. The MEMS device includes a single proof mass and suspension spring systems that movably couple the proof mass to a substrate. The suspension spring systems include translatory spring elements and torsion spring elements. The translatory spring elements enable translatory motion of the proof mass relative to the substrate in two orthogonal directions that are parallel to the plane of the MEMS device in order to sense forces in the two orthogonal directions. The torsion spring elements enable rotation of the proof mass about a rotational axis in order to sense force in a third direction that is orthogonal to the other two directions. The translatory spring elements have asymmetric stiffness configured to compensate for an asymmetric mass of the movable element used to sense in the third direction.

Abstract: A micro inertial measurement system includes a housing, a sensing module, and a damper. The sensing module includes a rigid sensing support, a measuring and controlling circuit board mounted on the rigid sensing support and an inertial sensor set on the measuring and controlling circuit board. The inertial sensor includes a gyroscope and an accelerometer. The sensing module is mounted in the housing. The damper is mounted in the housing and set in the gap between the sensing module and the inside wall of the housing. By use of the above-mentioned structure, the noise immunity of the inertial measuring system can be greatly improved, and the volume and weight of the inertial measuring system can be greatly reduced.

Abstract: A low-cost and high-precision current sensing device and methods for use and manufacturing. In one embodiment, the current sensing apparatus comprises a Rogowski-type coil which is manufactured in segments so as to facilitate the manufacturing process. In an exemplary embodiment, the current sensing apparatus segments comprise a number of bobbin elements that are wound and subsequently formed into complex geometric shapes such as torus-like shapes. In an alternative embodiment, bonded windings are utilized which allow the segments to be formed without a bobbin or former. In yet another alternative embodiment, the aforementioned current sensing devices are stacked in groups of two or more. Methods of manufacturing and using the aforementioned current sensing apparatus are also disclosed.

Abstract: In the present invention the issue of calculating voltage drop at the contact points of the power network with injected power currents is proposed. The method consists of the three steps. First, the said power network is partitioned into sub-networks. Secondly, the said sub-networks are expressed in terms of their admittance matrices and voltage transfer functions, which are then fed into timing simulator handling both time and frequency to compute the voltage drop at the said contact points. To achieve better partition result, inputs, outputs including user assigned nodes for recording voltages, are utilized to absorb the sub-network without inputs and outputs into the same partition as its parent node, and generate output cone with single input and outputs. Timing simulator uses convolution to get input voltage at each time step recursively and then voltage transfer used to evaluate output voltage at the same time step with minimal computational overhead.

Abstract: A wireless mesh network is configured to manage a power grid. Each node within the wireless mesh network is configured to detect and classify voltage fluctuations in power supplied by an upstream transformer coupled to the power grid. When a given node detects a particular type of fluctuation (i.e., an “event”), the node generates a timestamped event classification that reflects the type of event and a time when the event occurred. A server configured to manage the wireless mesh network receives timestamped event classifications from each node within the wireless mesh network and then performs a time correlation with the received timestamped event classifications to determine which nodes detected similar events. When two or more nodes detected the same event at similar times, the server determines that those nodes are coupled to the same transformer.

Abstract: An apparatus is provided for RF signal discrimination. A master laser of the apparatus is connected to an optical input of an optical phase modulator. The optical phase modulator is configured to receive a plurality of RF signals at an RF input and further configured to receive an output from the master laser at an optical input. A slave laser operating below a lasing threshold is configured to receive a modulated output from the optical phase modulator. An optical filter is configured to receive a mixed signal generated inside the slave laser. A photodetector receives the filtered mixed signal and is configured to recover a RF signal from the plurality of RF signals, where a frequency of a sideband of the recovered RF signal corresponds to a mode of the slave laser.

Abstract: Exemplary embodiments of the present disclosure are directed to diagnostic testing of electrical power cables using a resonant test system. The resonant test system can be configured to adjust an inductance to set the inductance of the resonant test system to a test inductance value and to adjust an output frequency of the resonant test system to set the output frequency to a test output frequency. The inductance of the resonant test system can be adjusted by controlling a reactor of the resonant test system and the output frequency of the resonant test system can be controlled by an inverter of the resonant test system. The test inductance value and the test output frequency the test inductance value and the test output frequency can be automatically and dynamically set by a controller of the resonant test system to achieve resonance in series with an electrical power cable under test. One or more diagnostic tests can be performed on the electrical power cable.

Abstract: A method for detecting a wiring fault in a capacitive sensor (1), such as a knock sensor, connected, via a passive acquisition interface (5), to a communication port (P1), that can be configured in either input mode or output mode, of a computer (2), wherein the communication port (P1) is configured in output mode, and a square wave voltage Vn capable of at least partially charging the capacitors (C6, C7, C8a, C8b, C10) of the acquisition interface (5) and the capacitive sensor (1) is generated during a time interval Tc, after which the communication port is switched to its input mode, so that at least one data element representative of the voltage of the capacitors and of the capacitive sensor is acquired, and finally these data are compared with previously stored reference data so that a wiring fault can be deduced if there is no matching between the data.

Abstract: Apparatus and method are provided for testing continuity of a ring circuit of an electricity distribution system, the ring circuit including at least a first conductor connecting, in a ring configuration, a source of electricity to a plurality of accessories. The apparatus includes: a switch arranged to cause a break in the ring circuit at a location in the ring circuit, the break resulting in a first end and a second end of the ring circuit at the location; a detector for measuring the relative voltage between the first end and the second end of the ring circuit; and an indicator which indicates, responsive to the detector detecting a relative voltage between the first end and the second end of the ring circuit, that there is a lack of continuity in the ring circuit.

Abstract: Systems and methods for connectors with insertion counters are provided. In one embodiment, a connector comprises: an interface configured to interface with a corresponding interface of a port to communicate signals between the port and a cable attached to the connector; at least one switch configured to change from a first state to a second state when the connector is inserted into the port; and a microcontroller configured to record insertion events, wherein the microcontroller increments an insertion count stored within the microcontroller when the at least one switch transitions from the first state to the second state.

Abstract: A receptacle testing device for testing the wiring condition of three phase receptacles is disclosed. The receptacle testing device may be used for performing a quick check of the wiring of three phase receptacles to assess that power is present at the correct terminals within the receptacle, and that the neutral and ground wires are properly wired.

Abstract: A built-in test system includes a control circuit, a transient voltage suppressor circuit, and a test switch. The control circuit is configured to receive a signal, and the transient voltage suppressor circuit includes first and second transient voltage suppressors connected in series between the signal and ground. The test switch is connected to selectively conduct current between the signal and a node between the first and second transient voltage suppressors. The control circuit is configured to control the test switch to test the first and second transient voltage suppressors.

Abstract: An approach for transmission line pulse and very fast transmission line pulse reflection control is provided. The approach includes using a power splitter to split an incident pulse into two identical pulses with one going to a device under test (DUT) through a delivery cable and the other going down an open ended delay cable. The structure of the power splitter, along with having the delivery cable and the open ended delay cable with the same signal propagation time and pulse transmission characteristics enable the canceling of pulse reflections from the DUT.

Abstract: In an example implementation, an integrated circuit (IC) includes: a plurality of transistors disposed in a plurality of locations on a die of the IC; conductors coupled to terminals of each of the plurality of transistors; a digital-to-analog converter (DAC), coupled to the conductors, to drive voltage signals to the plurality of transistors in response to a digital input; and an analog-to-digital converter (ADC), coupled to at least a portion of the conductors, to generate samples in response to current signals induced in the plurality of transistors in response to the voltage signals, the samples being indicative of at least one electrostatic characteristic for the plurality of transistors.

Abstract: A method for testing a signal path of a first IC formed as a monolithically integrated circuit on a semiconductor body together with a magnetic field sensor and has a signal output and a power supply connection and a test mode state and a normal operating state. A power supply of the first IC is switched off, and a signal output is connected with a reference potential, and the power supply of the first IC is switched on and the signal output is disconnected from the reference potential. Subsequently in a test mode state, a self-test is performed in the first IC and a test pattern is configured at the signal output or at the power supply connection and the test pattern is evaluated by the control unit for testing of the signal path.

Abstract: A method for electrical testing of a 3-D integrated circuit chip stack is described. The 3-D integrated circuit chip stack comprises at least a first integrated circuit chip and a second integrated circuit chip. The first integrated circuit chip and the second integrated circuit chip are not soldered together for performing electrical testing.

Abstract: A method implements fixed-point polynomials in hardware logic. In an embodiment the method comprises distributing a defined error bound for the whole polynomial between operators in a data-flow graph for the polynomial and optimizing each operator to satisfy the part of the error bound allocated to that operator. The distribution of errors between operators is updated in an iterative process until a stop condition (such as a maximum number of iterations) is reached.

Abstract: A semiconductor device includes a built-in self-test controller suitable for generating a test command and test data, and generating a test result signal in response to test result data, in a built-in self-test mode, an internal circuit suitable for performing a test operation in response to the test command and the test data and generating the test result data as a result of the test operation, and a signal transfer controller suitable for outputting the test command, the test data, and the test result signal through a set probe pad and a set bump pad in the built-in self-test mode.

Abstract: A semiconductor device and a method for testing the same are provided. The semiconductor device includes a plurality of semiconductor dies staked, a plurality of through-electrodes disposed between the semiconductor dies, a first calculation unit calculating a first output value from input signals inputted into the through-electrodes by a logical operation, a second calculation unit calculating a second output value from output signals outputted from the through-electrodes by a logical operation, and a comparator comparing the first output value with the second output value.

Abstract: A scan flip-flop includes an input unit and a flip-flop. The input unit is configured to select one signal from among a data input signal and a scan input signal to supply the selected one signal as an internal signal according to an operation mode. The flip-flop os configured to latch the internal signal according to a clock signal. The flip-flop includes a cross coupled structure that includes first and second tri-state inverters which share a first output node and face each other.

Abstract: A semiconductor package may include a probe circuit unit configured to be driven by buffering a signal received from a probe pad during probe testing, a bump circuit unit configured to buffer a signal received from a bump pad, and a power-source selection unit configured to change a level of an internal power-supply voltage applied to the probe circuit unit in response to a test-mode signal.

Abstract: This invention is time stamping subsystem of an electronic apparatus. A time stamp generator generates a multibit time stamp value including a predetermined number of least significant bits overlapping a predetermined number of most significant bits. Each client receives the least significant bits. Each client associates captured data with a corresponding set of the least significant bits in a message. A central scheduling unit associates most significant bits of the time stamp value with the least significant bits of the message. This associating compares overlap bits of the most significant bits and least significant bits. The most significant bits are decremented until the overlap bits are equal.

Abstract: A system includes a proportional-integrated-derivative (PID) regulator. The system also includes a fault detection unit. The fault detection unit is for receiving at least two outputs from the PID regulator. The at least two outputs include at least two rotor reference frame (D-Q) currents. The fault detection unit is further for generating a detection signal based on the at least two rotor reference frame currents. The detection signal identifies a fault based on the fault detection signal amplitude value based on the magnitudes of the amplitudes for each of the at least two rotor reference frame D-Q currents. The fault detection unit is for identifying an existence of a permanent magnet motor fault based on a comparison between the fault detection signal amplitude value and an amplitude threshold value. Further the fault localization signature is utilized to locate the location of the fault.

Abstract: A method and apparatus to detect cell voltage of each of a plurality of battery cells in a rechargeable battery pack is disclosed. The method comprises generating a square wave form with a positive phase and a negative phase, sending the square wave form to a first circuit that is connected to a battery cell and to a second circuit with matching components of the first circuit, and finally driving a matching voltage of the second circuit to become equivalent to the battery cell voltage for measurement.

Abstract: An estimation method for SOC of lithium iron phosphate power battery packs, include: 1, selecting a secondary battery (A) having characteristics of linear relationship between terminal voltage and SOC1; 2, connecting the secondary battery (A) with lithium iron phosphate power battery packs (B) in series, 3, repeatedly detecting values of the SOC1 and values the terminal voltages Ua of the secondary battery during the secondary battery is charging or discharging, fitting a formula (1) between the SOC1 and the terminal voltage Ua, the formula (1) being shown as following: SOC1=K1*Ua+M1 (1); 4, obtaining a formula (2) between SOC1 and SOC of the lithium iron phosphate power battery pack: SOC1=K2*SOC+M2 (2); 5, by formula (1) and formula (2), obtaining a formula (3) for calculating the SOC of the lithium iron phosphate power battery pack, the formula (3) being shown as following: SOC=Ua*K1/K2+(M1?M2)/K2 (3).

Abstract: A first pattern and a second pattern are stacked with each other. In a pattern of a first circuit for high voltage, a GND is formed as a solid pattern. In a pattern of a second circuit for low voltage, a GND is formed as a solid pattern. The solid pattern of the GND of the pattern of the first circuit for high voltage and the solid pattern of the GND of the pattern of the second circuit for low voltage partially face each other, thereby improving noise-resistant performance of the circuit for high voltage.

Abstract: By configuring low-pass filters each with a resistor and a capacitor, noise is removed. Based on a reference value of DC voltage that appears at output terminals of a battery pack circuit, a lowering portion of capacitance that arises in the respective capacitors is estimated in advance, and a compensation value is included in the resistance value of the respective resistors such that the cutoff frequencies of the low-pass filters are within an intended range. Even when a high voltage is handled, the variance in cutoff frequencies can be prevented from arising and the noise in an unnecessary frequency domain can be adequately reduced.

Abstract: A battery monitoring device includes: a current detection unit that detects an electric current flowing through a battery; a voltage detection unit that detects a voltage between both ends of the battery; a temperature detection unit that detects the temperature of the battery; an internal resistance increase rate calculation unit that calculates the internal resistance increase rate of the battery based on the detected electric current, voltage between the both ends, and temperature; and a calculation invalid time setting unit that sets a predetermined calculation invalid time according to the characteristics of the internal resistance increase rate. The calculation results of the internal resistance increase rate is invalidated for an invalid period from the start of charging or discharging of the battery to the lapse of the calculation invalid time.

Abstract: A battery system for a portable information handling system may modify charging parameters based on temperature exposure of a battery. When the battery is charged and exposed to a high temperature, the battery may be discharged to a lower voltage. After a cumulative period of exposure to a high temperature, a top-of-charge (TOC) voltage may be permanently reduced for the battery. Prior to charging at a high temperature, the TOC voltage may be reduced for a next charge cycle. Reducing the TOC voltage may minimize adverse effects for battery performance.

Abstract: This disclosure relates to a method for monitoring the state of a battery of a motor vehicle, with which method internal corrosion in the battery can be identified. In this case, the water loss from the battery is estimated by means of a model, and an evaluation unit generates an alarm signal if the estimated water loss exceeds a defined limit value. The water loss model provides, in particular, that the z-curve, which is used in the charging strategy of the battery, and the battery temperature are used, and the mass flow of the water loss on account of gas development is determined as a function of the used z-curve and the battery temperature from a correlation, which is stored in the evaluation unit, at least between the mass flow of the water loss on account of gas development, a z-curve of the charging strategy and the battery temperature.

Abstract: Methods and circuits are described in which an SLS driver circuit includes an SLS driver current source that may be arranged to provide an SLS current to a series SLS chain at a series SLS node. The series SLS chain may include a plurality of SLSs connected in series. The SLS driver circuit also includes a diagnostic current source that is arranged to provide a diagnostic current to a diagnostic resistor at a diagnostic resistor node. The series SLS chain also includes a comparison circuit that may be arranged to compare a series SLS voltage at the series SLS node with a diagnostic voltage at the diagnostic resistor node, and to output a status signal based on a result of the comparison such that the status signal is based, at least in part, on whether a failure condition exists in the series SLS chain.

Abstract: A device for the measuring and closed-loop control of a magnetic field generated by means of an electromagnet (5, 12, 15), comprising a first measuring device (10) for purposes of measuring the absolute magnetic field strength of the magnetic field, a second measuring device (11) for purposes of measuring the alteration of the magnetic field strength of the magnetic field, at least two integrators (20) for purposes of determining the magnetic field strength of the alteration of the magnetic field strength measured in the second measuring device (11), which integrators are arranged in parallel to one another, calibration means, a unit for purposes of comparing the magnetic field strength measured by the first measuring device (10) and the second measuring device (11), and a further unit for purposes of comparing the measured magnetic field strength with a prescribed design field strength, and a method.