Patents Issued in August 16, 2016
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Patent number: 9416060Abstract: An agricultural blend, an agricultural binder system, and a process of forming an agricultural blend are described. The agricultural blend includes a binder system having soy polymer and one or both of metal slag by-product and synthetic gypsum. The agricultural binder system includes soy polymer. The agricultural binder system is a powder. The process of forming an agricultural blend includes blending a binder system having soy polymer with one or both of metal slag by-product and synthetic gypsum to form the agricultural blend.Type: GrantFiled: February 3, 2015Date of Patent: August 16, 2016Assignee: HARSCO CORPORATIONInventors: Stephen R. Miranda, Kimberly A. Papania
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Patent number: 9416061Abstract: A composition of matter comprising: a combination of a phytate and a plurality of microorganisms comprising a Trichoderma virens fungus, a Bacillus amyloliquefaciens bacterium, and one or a plurality of mycorrhizae fungi that is placed in the vicinity of a plant root in a manner that allows the microorganisms in the composition of matter to colonize said plant root; and a method for increasing plant yield comprising: placing a combination of a phytate and a plurality of microorganisms comprising a Trichoderma virens fungus, a Bacillus amyloliquefaciens bacterium, and one or a plurality of mycorrhizae fungi in the vicinity of a plant root in a manner that allows the microorganisms in the composition of matter to colonize said plant root.Type: GrantFiled: April 13, 2015Date of Patent: August 16, 2016Assignee: NOVOZYMES BIOAG A/SInventor: Thomas D. Johnson
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Patent number: 9416062Abstract: This invention relates to processes and systems for converting fresh food waste into nutrient rich hydrolysates and particulate compositions. The invention also relates to the hydrolysates and compositions useful, for example, as fertilizers, feedstock or other nutrient supplements.Type: GrantFiled: September 29, 2015Date of Patent: August 16, 2016Assignee: CAL SAFE SOIL, LLCInventors: Daniel M. Morash, Mark LeJeune
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Patent number: 9416063Abstract: Improved agriculturally useful products are provided, including solid materials such as nitrogenous fertilizers (e.g., urea), together with a polycarboxylated polymer selected from the group consisting of a salts of copolymers containing individual quantities of maleic and itaconic moieties. The polymer composition also includes from about 10-60% by weight of an organic drying agent such as a lower alcohol which enhances the quick drying properties thereof. The compositions may also include an amount of boron, and bimodal vinylic polymer made up of quantities of high and low molecular weight (MW) vinylic polymers such as PVA.Type: GrantFiled: April 28, 2014Date of Patent: August 16, 2016Assignee: Verdesian Life Sciences, LLCInventors: John Larry Sanders, Grigory Mazo, Jacob Mazo
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Patent number: 9416064Abstract: A method for producing controlled-release fertilizer coated with polyurethane is provided, wherein granular fertilizer is preheated under fluidized state in a fluidized bed; the surface of the granular fertilizer is pretreated after liquid paraffin being atomized; polyol and isocyanate are mixed in a nozzle, then atomized and sprayed onto the surface of the granular fertilizer; after the reaction materials are added, liquid paraffin is added for surface release treatment.Type: GrantFiled: August 6, 2014Date of Patent: August 16, 2016Assignee: CHINESE ACADEMY OF AGRICULTURAL SCIENCES INSTITUTE OF AGRICULTURAL RESOURCES AND REGIONAL PLANNINGInventors: Xiangdong Yang, Bingqiang Zhao, Yanting Li, Juan Li, Zhian Lin, Liang Yuan
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Patent number: 9416065Abstract: Described herein are compositions comprising an acidifier intermixed with an emulsifier and a co-surfactant that form stable microemulsions in water. Also described are methods of dispersing a compound in an aqueous solution using the compositions of the present invention.Type: GrantFiled: February 5, 2008Date of Patent: August 16, 2016Assignee: Archer Daniels Midland CompanyInventors: Shireen Baseeth, Bruce Sebree
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Patent number: 9416066Abstract: Catalysts supports and catalysts capable of being used in heterogeneous catalysis. The catalyst support belongs to the porous supports based on silicon carbide (SiC), in particular, based on ?-SiC, modified by a surface deposit of TiO2.Type: GrantFiled: June 24, 2013Date of Patent: August 16, 2016Assignees: Sicat Catalysts, Inc., Centre National de la Recherche Scientifique, Universite de StrasbourgInventors: Yuefeng Liu, Cuong Pham-Huu, Patrick Nguyen, Charlotte Pham
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Patent number: 9416067Abstract: The present invention relates to a catalyst composition comprising cobalt manganese oxide which is modified with lanthanum and/or phosphorus and optionally one or more basic elements selected from the group consisting of alkali metal, alkaline earth metal and transition metal. Furthermore, a method for preparing said catalyst composition and a process for producing aliphatic and aromatic hydrocarbons by Fischer-Tropsch synthesis using said catalyst composition is provided.Type: GrantFiled: December 15, 2011Date of Patent: August 16, 2016Assignee: Saudi Basic Industries CorporationInventors: Khalid Karim, Saleh A. Al-Sayari
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Patent number: 9416068Abstract: The invention relates to a method for producing liquid fuel having a high alkane content and a low oxygenized compound content, said method comprising at least: a first step of treating 2-methylfuran with a catalyst and water in reaction conditions in order to form a mixture of products with at least ten carbon atoms; and a second step of catalytic hydrogenation and dehydration of the product or the mixture obtained in step 1, using suitable hydrogenation and dehydration catalysts.Type: GrantFiled: December 14, 2012Date of Patent: August 16, 2016Assignees: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), UNIVERSIDAD POLITECNICA DE VALENCIAInventors: Avelino Corma Canos, Michael Renz, Olalla De La Torre Alfaro
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Patent number: 9416069Abstract: Disclosed is a method of producing a polyolefin composition comprising contacting a metallocene pre-catalyst, a co-catalyst, a primary surrogate, and a secondary surrogate; adding a first olefin monomer; and polymerizing the first monomer for a time sufficient to form the polyolefin. Also disclosed is a method of producing a block polyolefin composition comprising contacting a metallocene pre-catalyst, a co-catalyst, a primary surrogate, and a secondary surrogate; polymerizing the first monomer for a time sufficient to form the polyolefin; adding a second monomer; and polymerizing the second olefin monomer for a time sufficient to form said block polyolefin composition. The method allows for the production of polyolefins of low molecular weights and narrow molecular weight distributions.Type: GrantFiled: January 4, 2011Date of Patent: August 16, 2016Assignee: University of Maryland, College ParkInventors: Lawrence R. Sita, Jia Wei
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Patent number: 9416070Abstract: A method that includes forming ethylene from methane including contacting supported-palladium with hydrogen sulfide to form a palladium sulfide catalyst and contacting the palladium sulfide catalyst with methane to form ethylene.Type: GrantFiled: July 18, 2013Date of Patent: August 16, 2016Assignee: Northwestern UniversityInventors: Tobin J. Marks, Chao Xie
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Patent number: 9416071Abstract: A hydrocarbon conversion process is described. The process involves contacting a hydrocarbon feed with a lactamium based ionic liquid catalyst in a reaction zone under reaction conditions to form a mixture comprising reaction products, and the lactamium based ionic liquid catalyst. Typical hydrocarbon conversion processes include alkylation, oligomerization, isomerization, disproportionation, and reverse disproportionation.Type: GrantFiled: December 1, 2014Date of Patent: August 16, 2016Assignee: UOP LLCInventors: Erin M. Broderick, Stuart Smith, Alakananda Bhattacharyya, Susie C. Martins
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Patent number: 9416072Abstract: A feedstream comprising paraxylene and styrene is contacted, in the presence of hydrogen, with a catalyst comprising at least one metal, selected from one or more metals selected from Groups 8-10.Type: GrantFiled: May 2, 2016Date of Patent: August 16, 2016Assignee: ExxonMobil Chemical Patents Inc.Inventors: Tan-Jen Chen, John D. Ou, Jeevan S. Abichandani, Glenn A. Heeter
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Patent number: 9416073Abstract: In the halogenation reaction of olefin/halo-olefin (i.e., organic), an excess amount of halogen gas (fluorine, chlorine, vaporized bromine and iodine, or their combination) is normally used in order to achieve as complete as possible conversion of the organic. In a conventional process, the excess halogen gas in the off-gas stream is scrubbed by caustic solution which increases the consumption of halogen and generates waste for disposal. The present invention provides a novel process to recover and reuse the excess halogen gas and thus reduce the operating cost of the process.Type: GrantFiled: October 2, 2015Date of Patent: August 16, 2016Assignee: Honeywell International Inc.Inventors: Terris Yang, Hsueh Sung Tung
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Patent number: 9416074Abstract: The present invention relates, in part, to the discovery that the presence of impurities in a reactor for dehydrochlorinating HCFC-244bb to HFO-1234yf results in a reduced conversion rate and/or a selectivity changeover from HFO-1234yf to HCFO-1233xf. By substantially removing such impurities, it is shown that the conversion rate may be improved and selectivity to HFO-1234yf via dehydrochlorination of HCFC-244bb is also improved.Type: GrantFiled: October 10, 2012Date of Patent: August 16, 2016Assignee: HONEYWELL INTERNATIONAL INC.Inventors: Haiyou Wang, Hsueh Sung Tung, Daniel C. Merkel
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Patent number: 9416075Abstract: The present invention is a method for 2-fluorobutane to obtain highly purified 2-fluorobutane through a process comprising a step for: bringing crude 2-fluorobutane that includes 5 to 50 wt % of butene into contact with a brominating agent that can form a bromonium ion in an aprotic polar solvent in the presence of water or an alcohol having up to 4 carbon atoms; converting the butene into compounds having a boiling point higher than that of 2-fluorobutane, then recovering 2-fluorbutane from the reaction solution; and purifying the recovered 2-fluorabutane by distillation.Type: GrantFiled: July 16, 2014Date of Patent: August 16, 2016Assignee: ZEON CORPORATIONInventor: Tatsuya Sugimoto
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Patent number: 9416077Abstract: An integrated plant is provided to improve carbon utilization of carbon molecules from gasified woody biomass to be converted into methanol. Detectors ensure a minimized sulfur content of less than 0.05% by dry weight of the woody biomass. A biomass gasifier reacts woody biomass in a rapid gasification reaction to produce a syngas composition having a ratio of hydrogen to carbon dioxide that is higher than needed for methanol synthesis. Parallel to the gasifier, a hydrocarbon reforming reactor provides a syngas composition having a ratio of hydrogen to carbon monoxide that is higher than needed for methanol synthesis. The combined syngas mixture from the biomass gasifier and the hydrocarbon reforming reactor comprises feed to a methanol synthesis plant, such that a majority of the carbon dioxide produced by the biomass gasification reaction and the hydrogen produced by the hydrocarbon reforming reactor are synthesized into methanol.Type: GrantFiled: September 13, 2013Date of Patent: August 16, 2016Assignee: Sundrop Fuels, Inc.Inventors: Renus Constantyn Kelfkens, Herbert Mark Kosstrin
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Patent number: 9416079Abstract: A process for preparing 4-cyclohexyl-2-methyl-2-butanol, comprising: a) reaction of styrene with isopropanol at elevated temperature to obtain 2-methyl-4-phenyl-2-butanol, and b) heterogeneously catalyzed hydrogenation of 2-methyl-4-phenyl-2-butanol over a catalyst suitable for ring hydrogenation of aromatics, where the molar ratio of the styrene used in step a) to the isopropanol used in step a) is in the range from 1:below 5 to 1:0.5.Type: GrantFiled: May 12, 2015Date of Patent: August 16, 2016Assignee: BASF SEInventors: Rudolf Schuch, Stefan Rüdenauer, Klaus Ebel, Ralf Pelzer, Andreas Keller
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Patent number: 9416080Abstract: Disclosed is a method for the transition metal-mediated oxidation of C—H bonds to form C—O or C—S bonds. The methods are useful for the formation of ethers (R—OR?) from alcohols, R?OH, and sp3-hybridized C—H bonds in substrates, R—H. Aryl or heteroaryl acetates may also be used for C—H to C—OAr bond formation. The methods are also useful in the preparation of C—S bonds from acetyl-protected thiols, MeC(O)SR, and disulfides, RSSR. Advantageously, the methods minimize reaction steps, the handling of oxidized intermediates, and environmental impact.Type: GrantFiled: June 14, 2013Date of Patent: August 16, 2016Assignee: Georgetown UniversityInventors: Timothy H. Warren, Nicholas G. Sapiezynski
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Patent number: 9416081Abstract: Provided is a method for producing an aldehyde that provides a target aldehyde at a high conversion rate over an extended period of time. It is a method for producing an aldehyde comprising bringing a raw material gas containing a primary alcohol having 4 to 18 carbon atoms and water into contact with a dehydrogenation catalyst containing copper and iron so as to dehydrogenate the alcohol contained in the raw material gas, thereby obtaining an aldehyde, wherein the raw material gas has a water partial pressure of 0.2 kPa to 99 kPa.Type: GrantFiled: December 2, 2013Date of Patent: August 16, 2016Assignee: KAO CORPORATIONInventors: Ryo Nishimura, Jun Kono, Tsubasa Arai
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Patent number: 9416082Abstract: The present invention concerns a process for the isomerization of an exo double bond toward an endo double bond being performed in the presence of a catalyst system comprising palladium (Pd) or platinum (Pt) and molecular hydrogen or a hydrogen source.Type: GrantFiled: February 7, 2014Date of Patent: August 16, 2016Assignee: Firmenich SAInventors: Ramez Boshra, Koenraad Vanhessche, Anatoly Alexander
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Patent number: 9416083Abstract: The present invention relates to a new method for isolating ingenol (C20H28O5) from mixtures of diterpenoid esters and ingenol esters in a single step. Ingenol isolated by means of this method can be used as a precursor for the synthesis of biologically active ingenol derivatives, such as ingenol-3-angelate and ingenol-3-tigliate.Type: GrantFiled: October 26, 2015Date of Patent: August 16, 2016Assignee: INDENA S.P.A.Inventors: Maria Luz Bellido Cabello De Alba, Giovanni Appendino, Alberto Pagani, Eduardo Munoz Blanco
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Patent number: 9416084Abstract: The present invention relates to methods of producing ingenol-3-angelate (I) from ingenol (II). Furthermore, the invention relates to intermediates useful for the synthesis of ingenol-3-angelate (I) from ingenol (II) and to methods of producing said intermediates.Type: GrantFiled: December 1, 2014Date of Patent: August 16, 2016Assignee: LEO Laboratories LimitedInventors: Thomas Hogberg, Gunnar Grue-Sorensen, Xifu Liang, Anne Marie Horneman, Anders Klarskov Petersen
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Patent number: 9416085Abstract: A process for the manufacture of a perfluorooxycarboxylate of formula (I): RfO—CF2CF2—O—CF2—COOXa (I), wherein Rf is a perfluoro(oxy)alkyl group, and Xa is H, a monovalent metal or an ammonium group of formula NRN4, with RN, equal or different at each occurrence, being H or a C1-6 hydrocarbon group, said process comprising: (A) reacting a perfluorovinylether of formula Rf—O—CF?CF2 with an ethylene glycol derivative selected among ethylene glycol (HO—CH2CH2—OH), glycolic acid (HO—CH2—COOH), glycolaldehyde (HO—CH2—CHO) and protected derivatives thereof, so as to yield the corresponding addition product of formula Rf—O—CFH—CF2—O—CH2-E, and E being selected among —CH2OH, —COOH and —CHO; (B) optionally protecting functional group E with suitable chemistry; (C) fluorinating the (protected) addition product to yield the corresponding perfluorinated addition product; (D) optionally deprotecting the perfluorinated addition product to yield corresponding acyl fluoride of formula Rf—O—CF2—CF2—O—CF2—C(O)F; and (E) hydrolType: GrantFiled: July 7, 2009Date of Patent: August 16, 2016Assignee: SOLVAY SPECIALTY POLYMERS ITALY S.P.A.Inventors: Giuseppe Marchionni, Vito Tortelli
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Patent number: 9416086Abstract: The invention provides processes for purification of streams containing carboxylic acids and carboxylic acid anhydrides without using the amount of high-cost, corrosion resistant alloy required for a distillation column. The invention provides methods in which streams containing carboxylic acids and carboxylic acid anhydrides are subjected to a hydrolysis process by combining them with a stoichiometric excess of water and optionally an added hydrolysis catalyst. The resulting hydrolyzed stream is subsequently separated to produce a stream containing carboxylic acid and water and a carboxylic acid product stream comprising carboxylic acid.Type: GrantFiled: December 30, 2010Date of Patent: August 16, 2016Assignee: Eastman Chemical CompanyInventors: Jerry Allan Barron, Brandon Tyler Earls, Carl Franklin Fillers, Robert Sterling Kline, Gregory Abbott Wellman, Jr.
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Patent number: 9416087Abstract: Processes for producing an ?,?-unsaturated carboxylic acid, such as acrylic acid, or a salt thereof, using solid promoters are disclosed. The solid promoters can be certain solid oxides, mixed oxides, and clays, illustrative examples of which can include alumina, zirconia, magnesia, magnesium aluminate, sepiolite, and similar materials.Type: GrantFiled: October 8, 2014Date of Patent: August 16, 2016Assignee: Chevron Phillips Chemical Company LPInventors: Mark L. Hlavinka, Max P. McDaniel
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Patent number: 9416088Abstract: A process for producing acetic acid is disclosed in which the recycle ratio of the mass flow of the light liquid phase recycled to the reactor to the mass flow of the aqueous recycle stream recycled to the reactor is less than or equal to 2.Type: GrantFiled: October 2, 2015Date of Patent: August 16, 2016Assignee: CELANESE INTERNATIONAL CORPORATIONInventors: Ronald D. Shaver, Yaw-Hwa Liu, Mark O. Scates
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Patent number: 9416089Abstract: A dielectric fluid composition for electrical apparatus comprises a functionalized 12-hydroxy stearic acid having desirable properties including a pour point less than ?30° C. and a fire point greater than 250° C. It may be prepared by a process wherein 12-hydroxy methyl stearate is transesterified by reaction with a C3-C20 alcohol to form an alkyl-12-hydroxy stearate, followed by esterification thereof with a linear or branched C4-C20 carboxylic acid. This acid may be a free acid chloride, a fatty acid, a carboxylic acid anhydride, or combination thereof. The resulting functionalized 12-hydroxy stearic acid exhibits improved thermoxidative capability, low temperature flowability, and increased fire point.Type: GrantFiled: September 26, 2012Date of Patent: August 16, 2016Assignee: Dow Global Technologies LLCInventors: Suh Joon Han, Dirk B. Zinkweg, Zenon Lysenko
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Patent number: 9416090Abstract: The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogs, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.Type: GrantFiled: February 2, 2013Date of Patent: August 16, 2016Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Joachim B. Kohn, Durgadas Bolikal
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Patent number: 9416091Abstract: Disclosed are methods for the catalytic transesterification of compounds having one or more ester groups and groups reactive under transesterification conditions, such as 1,1-disubstituted alkene compounds, with alcohols or esters and novel compositions prepared therefrom. Further disclosed are novel compounds and compositions prepared as a result of the methods.Type: GrantFiled: July 31, 2015Date of Patent: August 16, 2016Assignee: SIRRUS, INC.Inventors: Jeffrey M. Sullivan, Aniruddha Sudhir Palsule, Peter Rulon Stevenson, Kshitij Kishen Parab
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Patent number: 9416092Abstract: A transesterification process produces a (meth)acrylate ester product from a mixture comprising an alkyl(meth)acrylate reactant, an alcohol reactant, a catalyst, and a polymerization inhibitor. The mixture is subjected to reaction conditions sufficient to produce a product (meth)acrylate and a product alcohol, which are different than the reactants.Type: GrantFiled: February 11, 2013Date of Patent: August 16, 2016Assignee: Rohm and Haas CompanyInventors: David A. Flosser, Philippe P. Maillot, Nawal K. Sharma, Alejandro Ceron, Mingyu Ye
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Patent number: 9416093Abstract: This invention relates to a supported quaternary phosphonium catalyst, preparation thereof and use thereof in producing dialkyl carbonates. The supported quaternary phosphonium catalyst of this invention has the following average molecular structure (I), and is characterized by a relatively high and stable catalyst activity. wherein, each of X, L, n, R1, R2, R3 and is the same as that in the specification.Type: GrantFiled: May 15, 2013Date of Patent: August 16, 2016Assignees: China Petroleum & Chemical Corporation, Shanghai Research Institute of Petrochemical Technology, SinopecInventors: Liangfeng Chen, Wenjun He
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Patent number: 9416094Abstract: The invention relates to a method for producing diamines and polyamines of the diphenylmethane series in which, by using a coalescence auxiliary in the phase separation of the process product obtained in the scrubbing of the neutralized crude product, the fraction of water and thus also of water-soluble impurities in the organic MDA-containing phase is reduced. According to the invention, the coalescence auxiliary used is a filter bed made of coalescence fiber material. The di- and polyamines of the diphenylmethane series obtained after distillative purification of this MDA-containing organic phase are exceptionally suitable for the preparation of the corresponding isocyanates.Type: GrantFiled: April 8, 2014Date of Patent: August 16, 2016Assignee: Covestro Deutschland AGInventors: Thomas Knauf, Wolfgang Lorenz, Stefan Wershofen, Richard Adamson, Karsten Becker
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Patent number: 9416095Abstract: The present invention relates to new salts, complexes, crystals, solutions, dispersions, and slurries of threonine-N,N-diacetic acid or derivatives thereof, to formulations containing those, to processes to prepare those, and to the use thereof.Type: GrantFiled: July 11, 2014Date of Patent: August 16, 2016Assignee: AKZO NOBEL CHEMICALS INTERNATIONAL B.V.Inventors: Axel Carstens, Tjerk Oedse Boonstra, Alexey Borisovich Zaitsev, Martin Heus, Wouter Jan Veenis
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Patent number: 9416096Abstract: Disclosed herein are crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, which is a prodrug of methyl hydrogen fumarate. Crystalline form 1, Crystalline form 2, Crystalline 3, and Crystalline form 4 are disclosed.Type: GrantFiled: September 5, 2014Date of Patent: August 16, 2016Assignee: XenoPort, Inc.Inventors: Chen Mao, Randall A. Scheuerman, Sami Karaborni
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Patent number: 9416097Abstract: The invention provides crystalline minocycline base. In particular, three crystalline polymorphic forms, designated Form I, Form II and Form III, of minocycline base are provided. These are characterized by XRD and IR data. Processes for preparing the new polymorphic forms are also provided. For example, Form I is prepared by dissolving and/or suspending amorphous minocycline base in an organic solvent chosen from ethers followed by crystallization from the mixture.Type: GrantFiled: August 30, 2012Date of Patent: August 16, 2016Assignee: Hovione Scientia LimitedInventors: Zita Mendes, Jose Rafael Antunes, Susana Marto, William Heggie
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Patent number: 9416098Abstract: A biguanide derivative compound with N1-N5 substitution, which is represented by Formula 1, or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a pharmaceutical composition containing the same as an active ingredient are provided. The biguanide derivative may exhibit excellent effect on activation of AMPK? and inhibition of cancer cell proliferation in a low dose, compared to conventional drugs, and thus, may be useful to treat diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer, etc.Type: GrantFiled: January 6, 2011Date of Patent: August 16, 2016Assignee: IMMUNOMET THERAPEUTICS INC.Inventors: Sung Wuk Kim, Sung Soo Jun, Chang Hee Min, Young Woong Kim, Min Seok Kang, Byung Kyu Oh, Se Hwan Park, Yong Eun Kim, Duck Kim, Ji Sun Lee, Ju Hoon Oh
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Patent number: 9416099Abstract: Quaternary ammonium, betaine, or sulfobetaine compositions derived from fatty amines, wherein the fatty amine is made by reducing the amide reaction product of a metathesis-derived C10-C17 monounsaturated acid, octadecene-1,18-dioic acid, or their ester derivatives and a secondary amine, are disclosed. Quaternary ammonium, betaine, or sulfobetaine compositions derived from fatty amidoamines, wherein the amidoamine is made by reacting of a metathesis-derived C10-C17 monounsaturated acid, octadecene-1,18-dioic acid, or their ester derivatives and an aminoalkyl-substituted tertiary amine, are also disclosed. The quaternized compositions are advantageously sulfonated or sulfitated. In one aspect, the ester derivative of the C10-C17 monounsaturated acid or octadecene-1,18-dioic acid is a lower alkyl ester. In other aspects, the ester derivative is a modified triglyceride made by self-metathesis of a natural oil or an unsaturated triglyceride made by cross-metathesis of a natural oil with an olefin.Type: GrantFiled: September 28, 2015Date of Patent: August 16, 2016Assignee: Stepan CompanyInventors: Dave R Allen, Marcos Alonso, Randal J Bernhardt, Aaron Brown, Sangeeta Ganguly-Mink, Andrew Malec, Teresa Manuel, Ronald A. Masters, Lawrence A. Munie, Dennis S. Murphy, Patti Skelton, Brian Sook, Michael R. Terry, Jeremy Aaron Weitgenant, Laura Lee Whitlock, Michael Wiester, Patrick Shane Wolfe
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Patent number: 9416100Abstract: The present invention relates to a process for hydrogenating a substrate comprising a carbon-heteroatom double bond, the process comprising the step of reacting the substrate with hydrogen gas in the presence of a hydrogenation catalyst, wherein the hydrogenation catalyst is a complex of formula (I): R1-10, A and Hal are as defined in the specification. The present invention also provides processes for the preparation of the complex of formula (I) and intermediates thereof.Type: GrantFiled: March 17, 2010Date of Patent: August 16, 2016Assignee: Johnson Matthey Public Limited CompanyInventors: Alan Dyke, Damian Mark Grainger, Jonathan Alan Medlock, Hans Guenter Nedden, Jacques Jean Marie Le Paih, Stephen James Roseblade, Andreas Seger, Vilvanathan Sivakumar, Antonio Zanotti-Gerosa
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Patent number: 9416101Abstract: Provided herein are novel compounds, pharmaceutical compositions for use, inter alia, in methods of reducing Wnt-mediated effects and treating cancer.Type: GrantFiled: October 31, 2014Date of Patent: August 16, 2016Assignee: STEMSYNERGY THERAPEUTICS, INC.Inventor: Darren Orton
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Patent number: 9416102Abstract: Disclosed are (22E)-2-methylene-22-dehydro-1,24,25-trihydroxy-19-nor-vitamin D3 compounds, their biological activities, and various pharmaceutical uses for these compounds. Particularly disclosed are (22E)-(24R)-2-methylene-22-dehydro-1?,24,25-trihydroxy-19-nor-vitamin D3 and (22E)-(24S)-2-methylene-22-dehydro-1?,24,25-trihydroxy-19-nor-vitamin D3, their biological activities, and various pharmaceutical uses for these compounds.Type: GrantFiled: November 19, 2013Date of Patent: August 16, 2016Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Lori A. Plum, Rafal Barycki, Margaret Clagett-Dame
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Patent number: 9416103Abstract: Novel alkylindoles that bind tightly to cannabinoid receptors and are neutral antagonists for the cannabinoid 1 receptor and agonists for the cannabinoid 2 receptor are provided. These compounds are useful for treating alcoholism and drug abuse and for treating obesity.Type: GrantFiled: January 8, 2013Date of Patent: August 16, 2016Assignees: The Board of Trustees of the University of Arkansas, The University of KansasInventors: Paul L. Prather, Thomas E. Prisinzano, William E. Fantegrossi, Lisa K. Brents, Jeffery Moran, Anna Radominska-Pandya, Tamara Vasiljevik
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Patent number: 9416104Abstract: Described herein are compounds, pharmaceutical compositions and methods for inhibiting the expression of a vitamin D receptor target gene, inhibiting interactions between the vitamin D receptor and at least one vitamin D receptor coactivator, for treating cancer in a subject, and for inhibiting angiogenesis in a subject.Type: GrantFiled: August 26, 2012Date of Patent: August 16, 2016Assignees: UWM Research Foundation, Inc., Women and Infants' Hospital of Rhode IslandInventors: Alexander E. Arnold, Preetpal Singh Sidhu, Premchendar Nandhikonda, Rakesh K. Singh
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Patent number: 9416105Abstract: Described is an improved and industrially feasible process for the preparation of Saxagliptin or its hydrochloride salt. Also described are the novel intermediates and their use in the preparation of Saxagliptin or its hydrochloride salt.Type: GrantFiled: August 28, 2014Date of Patent: August 16, 2016Assignee: Amneal Pharmaceuticals LLCInventors: Agarwal Virendra Kumar, Siddiqui Arif Badrulhusan, Kataria Lalit Keshav, Maheta Abhay Subodhbhai, Butani Pankaj Changanbhai, Patil Shashikant Prabhakarrao, Patil Tushar Yashwant, Deore Ganesh Suryakant, Pansuriya Ketan Jahyantibhai, Patel Hitesh Sureshbhai, Sondharava Lalit Badhabhai
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Patent number: 9416106Abstract: Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.Type: GrantFiled: August 31, 2015Date of Patent: August 16, 2016Assignee: Northwestern UniversityInventors: Richard B. Silverman, Qing Jing
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Patent number: 9416107Abstract: A heterocyclic compound represented by Formula 1 below and an organic light-emitting device including the same: wherein Formula 1 is defined as in the detailed description.Type: GrantFiled: October 13, 2011Date of Patent: August 16, 2016Assignee: Samsung Display Co., Ltd.Inventors: Sun-Young Lee, Yoon-Hyun Kwak, Bum-Woo Park, Hee-Joo Ko, Jong-Hyuk Lee
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Patent number: 9416108Abstract: Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W is a bond, —C(?S)—, —S(O)—, —S(O)2—, —C(?O)—, —O—, —C(R6)(R7)—, —N(R5)— or —C(?N(R5))—; X is —O—, —N(R5)— or —C(R6)(R7)—; provided that when X is —O—, U is not —O—, —S(O)—, —S(O)2—, —C(?O)— or —C(?NR5)—; U is a bond, —S(O)—, —S(O)2—, —C(O)—, —O—, —P(O)(OR15)—, —C(?NR5)—, —(C(R6)(R7))b— or —N(R5)—; wherein b is 1 or 2; provided that when W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, U is not —S(O)—, —S(O)2—, —O—, or —N(R5)—; provided that when X is —N(R5)— and W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, then U is not a bond; and R1, R2, R3, R4, R5, R6, and R7 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I.Type: GrantFiled: December 18, 2014Date of Patent: August 16, 2016Assignee: Merck Sharp & Dohme Corp.Inventors: Zhaoning Zhu, Andrew W. Stamford
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Patent number: 9416109Abstract: The present disclosure provides compounds and methods that are useful for the preparation of compounds useful as orexin-2 receptor antagonists.Type: GrantFiled: February 14, 2013Date of Patent: August 16, 2016Assignee: Eisai R&D Management Co., Ltd.Inventors: George Anthony Moniz, Annie Zhu Wilcoxen, Farid Benayoud, Jaemoon Lee, Huiming Zhang, Taro Terauchi, Ayumi Takemura, Yu Yoshida, Toshiaki Tanaka, Keiichi Sorimachi, Yoshimitsu Naoe, Yuji Kazuta
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Patent number: 9416110Abstract: The invention provides processes for preparing a compound of formula I and salts thereof, wherein R1 is defined herein, and compounds and intermediates of said formula.Type: GrantFiled: May 17, 2013Date of Patent: August 16, 2016Assignees: Array BioPharma Inc., Genentech, Inc.Inventors: David Askin, Chong Han, Jonathan W. Lane, Travis Remarchuk, Sagar Shakya, C. Gregory Sowell, Keith L. Spencer, Peter J. Stengel
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Patent number: 9416111Abstract: The invention provides certain substituted diazine and triazine compounds of the Formula (I) (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Rcy, Cy, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.Type: GrantFiled: June 17, 2013Date of Patent: August 16, 2016Assignee: Merck Sharp & Dohme Corp.Inventors: Andrew M. Haidle, Michael D. Altman, Solomon D. Kattar, Matthew Christopher, John Michael Ellis, Christian Fischer, Alan B. Northrup, Kaleen Konrad Childers