Patents Issued in September 8, 2016
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Publication number: 20160257607Abstract: Lithium disilicate apatite glass-ceramics are described which are characterized by a high chemical stability and can therefore be used in particular as restoration material in dentistry.Type: ApplicationFiled: May 17, 2016Publication date: September 8, 2016Inventors: Christian RITZBERGER, Wolfram HOLAND, Marcel SCHWEIGER, Volker RHEINBERGER
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Publication number: 20160257608Abstract: The present invention relates to a glass ceramic powder comprising i) a glass material formed from a glass mixture containing a lithium and oxygen containing compound selected from Li2O and/or Li2CO3, SiO2, K2O, La2O3, and ii) seed particles comprising Li2SiO3 crystals and/or Li2Si2O5 crystals.Type: ApplicationFiled: October 17, 2014Publication date: September 8, 2016Inventor: Sigvald HARRYSON
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Publication number: 20160257609Abstract: The present disclosure relates to a composition comprising an expanded and micronized volcanic glass (EMVG) and at least one chemical agent, wherein the at least one chemical agent is coated on the surface of the volcanic glass. The present disclosure also relates to an improved process to remove mineral impurities and to coat the surface of the EMVG. The disclosed composition can be used a functional reinforcing filler to improve the mechanical properties of plastic.Type: ApplicationFiled: October 15, 2014Publication date: September 8, 2016Inventors: Athanasios KARALIS, Ioannis POULAKIS, Salvatore Peter LAROSA, Christina KAPRALOU, Gary Charles PHILLIPS, Nils RICKERTSEN, Christos DEDELOUDIS, Doukas EFSTATHIADIS
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Publication number: 20160257610Abstract: A sealed structural body has an internal space and is made of glass, wherein at least a part of a boundary between the internal space of the sealed structural body and the outside is separated by a sealing material containing a metal material and a lead-free oxide glass. The lead-free oxide glass contains at least one of element Ag or P, Te, and V.Type: ApplicationFiled: December 4, 2013Publication date: September 8, 2016Applicant: HITACHI, LTD.Inventors: Motomune KODAMA, Masanori MIYAGI, Takuya AOYAGI, Takashi NAITO
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Publication number: 20160257611Abstract: A coated glass pane comprising at least the following layers in sequence: a glass substrate; a lower anti-reflection layer; a silver-based functional layer; and at least one further anti-reflection layer; wherein the further anti-reflection layer comprises at least the following layers in sequence: at least one barrier layer; at least one absorbing layer based on tungsten nitride; and at least one dielectric layer.Type: ApplicationFiled: October 6, 2014Publication date: September 8, 2016Applicant: PILKINGTON GROUP LIMITEDInventors: AXEL NOETHE, THOMAS PAUL
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Publication number: 20160257612Abstract: A method for forming a porous soot body that includes depositing soot on a release coating supported by a bait substrate. Characteristics of the release coating control the strength of attachment of the porous soot body to the bait substrate. Weak attachment of the porous soot body to the bait substrate facilitates separation of the porous soot body from the bait substrate without damaging the porous soot body. The release coating may be formed from a brittle material or a material that oxidizes or otherwise depletes during deposition of the soot that forms the porous soot body. The release coating may include carbon. The separated porous soot body may be consolidated to form a core cane or may function as a sleeve (porous cladding) in a cane-in-soot fiber preform manufacturing process.Type: ApplicationFiled: February 22, 2016Publication date: September 8, 2016Inventors: Liam Ruan de Paor, Nicolas LeBlond, Richard Curwood Peterson, Kenneth William Roberts, Li Yang
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Publication number: 20160257613Abstract: An extrudable cement-based material is formed from a mixture that includes cement in the range of about 40 to 90% by wet weight percent, a lightweight expanded aggregate in the range of about 10 to 60% by wet weight percent, a secondary material in the range of about 0.1 to 50% by wet weight percent, a reinforcement fiber in the range of about 1 to 20% by wet weight percent, a rheology modifying agent in the range of about 0.5 to 10% by wet weight percent, a retarder in the range of about 0.1 to 8% by wet weight percent, and water in the range of 10 to 60% of a total wet material weight.Type: ApplicationFiled: April 24, 2014Publication date: September 8, 2016Inventors: Evan R. Daniels, Per Just Andersen
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Publication number: 20160257614Abstract: The invention relates to use of nano-fibrillar cellulose as an gas-entrainment stabilizer, which when used in cementitious materials, provides improved gas pore structure quality and/or stability and/or robustness with regard to water content variation. The invention further relates to a method for stabilizing gasentrainment of cementitious materials and to a method for providing cementitious material with improved air pore structure quality and/or stability and/or robustness with regard to water content variation.Type: ApplicationFiled: August 28, 2014Publication date: September 8, 2016Applicant: UPM-KYMMENE CORPORATIONInventors: Hannele Kuosa, Anna Suurnakki, Antti Laukkanen, Jan-Erik Teirfolk, Markku Leivo
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Publication number: 20160257615Abstract: An artificial decorative rock formed plastic recycled elements which include a body with an outer surface being constructed of layer of epoxy resin filled with hard sand-type particles or standard concrete. The outer surface of the artificial decorative rock having at one recess or protrusion. The recess at least lightens up the weight of the structure or the protrusion can be used to stabilize the rock if so desired. Furthermore the recess or protrusion can be manipulated to have a variety of functions.Type: ApplicationFiled: March 2, 2015Publication date: September 8, 2016Inventors: Evelyn White, Michael Crute
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Publication number: 20160257616Abstract: The present invention relates to a self-foaming geopolymer composition comprising at least one hydraulic binder; at least one binder selected from latent hydraulic binders, pozzolanic binders, and mixtures thereof; at least one alkaline activator; and aluminum dross. It moreover relates to the use of that geopolymer composition for the production of geopolymer foams and/or foamed geopolymer products.Type: ApplicationFiled: October 7, 2014Publication date: September 8, 2016Inventors: Burkhard WALTHER, Bernhard FEICHTENSCHLAGER, Shengzhong ZHOU
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Publication number: 20160257617Abstract: An amount-reduction, harmless, disposal method for heavy metal waste gypsum (HMWG), which belongs to the technical fields of recycling economy and environmental protection. The HMWG used as raw material is subjected to processes of smelting fluxpreparation, lead smelting, fuming, and geopolymeric gelling, to realize amount-reduction, harmless and resources recycling utilization of heavy metal waste gypsum. The smoke containing sulfur dioxide produced in the smelting process is sent to the acid making system, and the produced dust with heavy metal is sent to the dedicated system for heavy mental disposing. The smoke dust produced in the fuming process is returned to the lead smelting system. The secondary HMWG produced in the acid making system would be returned to the preparation process of smelting flux. And the final products would be sulfuric acid and geopolymer material.Type: ApplicationFiled: March 13, 2014Publication date: September 8, 2016Inventors: De an Pan, Shen gen ZHANG, Ling jie LI, Bin GUO, Bo LIU
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Publication number: 20160257618Abstract: Embodiments of a microstructure that allows arrest of contaminant infiltration includes an inter layer and at least one highly reactive ceramic layer. The inter layer is not reactive to an infiltrating reactive species. The HRC layer includes materials that react with a reactive contaminant species to slow or arrest infiltration of such contaminant species.Type: ApplicationFiled: February 10, 2016Publication date: September 8, 2016Applicant: The University of ConnecticutInventors: Eric H. Jordan, Maurice Gell, Rishi Kumar, Chen Jiang
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Publication number: 20160257619Abstract: A silicon carbide-natured refractory block includes a fire-resistant block body, and a calcination coated layer. The fire-resistant block body includes a silicon carbide-natured refractory having a predetermined configuration. The calcination coated layer includes silicon oxide made by heating an outer superficial portion of the fire-resistant block body to oxidize at least some of silicon carbide therein to turn the silicon carbide into the silicon oxide. The silicon oxide sinters the calcination coated layer to increase the corrosion resistance.Type: ApplicationFiled: March 3, 2016Publication date: September 8, 2016Applicant: TYK CorporationInventor: Kenji YANAGI
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Publication number: 20160257620Abstract: A low density annular grout composition for filling voids. The composition may consist of cementitious fly ash, water, set retarder and cellular foam. The composition may have a compressive strength of between 100 and 600 psi at seven days and less than 1500 psi at 28 days. The composition may have a density between 20 and 75 pcf. Also disclosed is a method of filling a void with a low density annular grout composition. The method can include determining the time necessary to fill the void, adding water and set retarder to a cementitious fly ash to make a wet mixture, adding air to the wet mixture, and adding the composition to the void.Type: ApplicationFiled: May 16, 2016Publication date: September 8, 2016Applicant: Flashfill Services, LLCInventors: Stanley R. Peters, Douglas Alex Hernandez, Darin R. Duran, William S. Caires, Brian P. Masloff, John Charles Fodor
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Publication number: 20160257621Abstract: The present invention relates to a method for increasing carbon assimilation of a plant, and thereby for increasing a biomass, and more specifically, to a fertilizer which can increase carbon assimilation of the plant and thereby increase biomass, and manufacturing method thereof. A plant growth accelerator according to the present invention includes a nano zerovalent iron. When the plant is exposed to the nano zerovalent iron, stomata of leaves are increased, carbon assimilation is increased and thus biomass is increased.Type: ApplicationFiled: December 8, 2015Publication date: September 8, 2016Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Yoon-Seok Chang, Hakwon Yoon, Jaehwan Kim, Inhwan Hwang, Youngjun Oh
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Publication number: 20160257622Abstract: The invention provides a new chemical process, a new cassette configuration, and new software. The invention allows one synthesizer in one hot cell to produce sequentially two batches of [18F]-labelled PET tracer in the same day.Type: ApplicationFiled: November 12, 2014Publication date: September 8, 2016Inventor: Xavier Franci
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Publication number: 20160257623Abstract: A process for oxygenate conversion using a family of crystalline aluminosilicate zeolites that is a layered pentasil zeolite with a silica or fluorine modified surface. These zeolites are represented by the empirical formula: Mmn+Rrp+Al1-xExSiyOz where M is an alkali, alkaline earth, or rare earth metal such as sodium or potassium, R can be a mixture of organoammonium cations and E is a framework element such as gallium, iron, boron, or indium. These zeolites are characterized by unique x-ray diffraction patterns and compositions and have catalytic properties for carrying out oxygenate conversion processes.Type: ApplicationFiled: March 3, 2015Publication date: September 8, 2016Inventors: Deng-Yang Jan, Nicholas J. Schoenfeldt, Jaime G. Moscoso
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Publication number: 20160257624Abstract: A process for the conversion of oxygenates to olefins is presented. The process utilizes a catalyst having a 2-dimensional morphology, and the catalyst is a pentasil zeolite. The process is an oxygenate to olefins conversion under typical temperatures and pressures, but provides for an increased propylene yield and a reduced ethylene yield.Type: ApplicationFiled: March 3, 2015Publication date: September 8, 2016Inventors: Nicholas J. Schoenfeldt, Jaime G. Moscoso, Deng-Yang Jan
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Publication number: 20160257625Abstract: A process for converting oxygenates to olefms comprising: a) contacting an oxygenate containing stream with a molecular sieve catalyst under oxygenate to olefms conversion conditions in a reactor to form an effluent comprising olefms; b) separating C3-hydrocarbons from C4+ hydrocarbons in the effluent; c) separating C1 hydrocarbons and other light gases from C2+ hydrocarbons; d) separating C2 hydrocarbons from the C3 hydrocarbons; e) sending the C3 hydrocarbons to a C3 splitter to separate pro pylene from propane; f) removing propylene from the C3 splitter; and g) removing propane from the C3 splitter.Type: ApplicationFiled: October 30, 2014Publication date: September 8, 2016Inventors: Jeroen Gerard MARSMAN, Leslie Andrew CHEWTER, Sivakumar SADASIVAN VIJAYAKUMARI, Jeroen VAN WESTRENEN
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Publication number: 20160257626Abstract: A process for converting oxygenates to olefins comprising: a) providing an oxygenate containing stream to an oxygenate to olefins conversion reactor; b) passing the oxygenate containing stream through a feed introduction system comprising one or more nozzles and one or more corresponding caps; c) contacting the oxygenate containing stream with a molecular sieve catalyst in the oxygenate to olefins conversion reactor to form an olefin containing product stream; and d) removing the product stream from the reactor.Type: ApplicationFiled: October 30, 2014Publication date: September 8, 2016Inventors: Richard Addison SANBORN, Sivakumar SADASIVAN VIJAYAKUMARI, Leslie Andrew CHEWTER, Ye-Mon CHEN
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Publication number: 20160257627Abstract: A process for the preparation of an alkene from an oxygenate comprising contacting a reactant feedstream comprising at least one oxygenate reactant and water with a supported heteropolyacid catalyst at a temperature of at least 170° C., wherein the process is initiated using a start-up procedure comprising the following steps: (i) heating the supported heteropolyacid catalyst to a temperature of at least 220° C.; (ii) maintaining the heat-treated supported heteropolyacid catalyst of step (i) at a temperature of at least 220° C. for a time sufficient to remove bound water from the heteropolyacid component of the supported heteropolyacid catalyst; (iii) under an anhydrous atmosphere, reducing the temperature of the heat-treated supported heteropolyacid catalyst of step (ii) to a temperature below 220° C.; and (iv) contacting the supported heteropolyacid catalyst of step (iii) with the reactant feedstream at a temperature of at least 170° C.Type: ApplicationFiled: May 16, 2016Publication date: September 8, 2016Inventor: Stephen Roy Partington
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Publication number: 20160257628Abstract: The invention relates to a method for producing latent heat storage material from linear alcohols by dehydrating to dialkyl ethers or to olefins, and hydrogenating to paraffins and dialkyl ether as a latent heat storage material.Type: ApplicationFiled: May 12, 2016Publication date: September 8, 2016Inventors: Holger Ziehe, Achim Weitze, Thoralf Gross
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Publication number: 20160257629Abstract: A process for the preparation of en alkene from an oxygenate comprising contacting a reactant feedstream comprising at least one oxygenate reactant and water with a supported heteropolyacid catalyst at a temperature of at least 170° C., wherein the process is initiated using a start-up procedure comprising the following steps: (i) heating the supported heteropolyacid catalyst to a temperature of at least 220° C.; (ii) maintaining the heat-heated supported heteropolyacid catalyst of step (i) at a temperature of at least 220° C. for a time sufficient to remove bound water from the heteropolyacid component of the supported heteropolyacid catalyst; and (iii) whilst maintaining the supported heteropolyacid catalyst of step (ii) at a temperature of at least 220° C., contacting the supported heteropolyacid catalyst with the reactant feedstream having a temperature of at least 220° C.Type: ApplicationFiled: May 16, 2016Publication date: September 8, 2016Inventor: Stephen Roy Partington
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Publication number: 20160257630Abstract: The invention relates to the in situ regeneration of heterogeneous oligomerization catalysts which are used in the liquid phase oligomerization of ethene.Type: ApplicationFiled: February 29, 2016Publication date: September 8, 2016Inventors: Guido Stochniol, Stephan Peitz, Dietrich Maschmeyer, Helene Reeker
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Publication number: 20160257631Abstract: A process for the production of para-xylene is presented. The process includes the isomerization of C8 aromatics to para-xylene utilizing a new catalyst. The new catalyst is a layer MFI zeolite and is represented by the empirical composition in the as synthesized and anhydrous basis expressed by the empirical formula of: Mmn+Rrp+AlSiyOz where M is at least one exchangeable cation selected from the group consisting of alkali and alkaline earth metals and R is at least one organoammonium cation.Type: ApplicationFiled: March 3, 2015Publication date: September 8, 2016Inventors: Gregory B. Kuzmanich, Jaime G. Moscoso, Deng-Yang Jan
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Publication number: 20160257632Abstract: A process for the production of para-xylene is presented. The process includes the isomerization of C8 aromatics to para-xylene utilizing a new catalyst. The new catalyst and designated as UZM-54 is represented by the empirical composition in the as synthesized and anhydrous basis expressed by the empirical formula of: Mmn+R1 r1p1+R2 r2p2+Al1-xExSiyOz where M is an alkali, alkaline earth, or rare earth metal such as sodium and/or potassium, R1 and R2 are organoammonium cation and E is a framework element such as gallium, iron, boron, or indium. UZM-54 are characterized by unique x-ray diffraction patterns, high meso surface area, low Si/Al ratios.Type: ApplicationFiled: March 3, 2015Publication date: September 8, 2016Inventors: Gregory B. Kuzmanich, Jaime G. Moscoso, Deng-Yang Jan
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Publication number: 20160257633Abstract: The present invention relates to processes for the preparation of (R)-1-(5-chloro-[1,1?-biphenyl]-2-yl)-2,2,2-trifluoroethanol, 1-(5-chloro-[1,1?-biphenyl]-2-yl)-2,2,2-trifluoroethanone, and intermediates thereof, which are useful in the preparation of inhibitors of TPH1 for the treatment of, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, low bone mass diseases, serotonin syndrome, and cancer.Type: ApplicationFiled: March 3, 2016Publication date: September 8, 2016Inventors: Stéphane De Lombaert, Daniel R. Goldberg
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Publication number: 20160257634Abstract: The invention is concerned with a process for preparing 2,2?-biaryls, especially of 2,2?-biphenols in which a reaction mixture comprising a first aryl, a second aryl and selenium dioxide is heated, the first aryl being reacted with the second aryl to give the corresponding 2,2?-biaryl, wherein the reaction mixture additionally comprises molybdenum(V) chloride.Type: ApplicationFiled: March 2, 2016Publication date: September 8, 2016Inventors: Katrin Marie Dyballa, Robert Franke, Dirk Fridag, Michael Mirion, Thomas Quell, Siegfried R. Waldvogel
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Publication number: 20160257635Abstract: A multi-reaction train hydroformylation process wherein a common product-catalyst separation zone is employed.Type: ApplicationFiled: December 9, 2014Publication date: September 8, 2016Inventors: Thomas C. Eisenschmid, Morteza Mokhtarzadeh, Cloid R. Smith, III, Michael C. Becker, George R. Phillips, Michael A. Brammer, Glenn A. Miller, Rick B. Watson, Irvin B. Cox, Edward A. Lord, Martin Lucas Smidt
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Publication number: 20160257636Abstract: A multi-reactor hydroformylation process wherein a common product-catalyst separation zone is employed.Type: ApplicationFiled: December 9, 2014Publication date: September 8, 2016Inventors: Glenn A. Miller, Jason F. Giles, Irvin B. Cox
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Publication number: 20160257637Abstract: The invention relates to a device comprising a feed which is arranged below the center of the device, a quenching agent inlet which is arranged above the feed, an outlet which is arranged below the feed, and a discharge which is arranged above the quenching agent inlet, said device having a region provided with one or more packets between the quenching agent inlet and the feed. The device is characterized in that at least one means is provided between the quenching agent inlet and a packet provided between the quenching agent inlet and the feed, said means ensuring the formation of a liquid layer with a height of at least 1 cm.Type: ApplicationFiled: August 11, 2014Publication date: September 8, 2016Inventors: Jürgen Mosler, Christian Psiorz, Franz-Felix Kuppinger, Raphael Schriewer, Arnd Bruhns, Armin Rix, Peter Kreis, Ralf Meier, James Edward Elder
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Publication number: 20160257638Abstract: Dicarboxylic acids, such as adipic acid, and diesters, such as adipates, may be produced by hydrogenating alkynes that may be produced from raw materials salvaged from waste stream processes. The carbons of the dicarboxylic acids are provided by alkynes generated from biomass waste and carbon dioxide recovered from waste streams such as exhaust gases.Type: ApplicationFiled: October 25, 2013Publication date: September 8, 2016Applicant: EMPIRE TECHNOLOGY DEVELOPMENT LLCInventor: Josef Peter KLEIN
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Publication number: 20160257639Abstract: The invention relates to an esterification unit (150) and esterification process for producing crude methyl methacrylate (MMA) from methacrylamide (MAM), which enable particularly to improve the yield, meaning that the organics spent acids are low; and at the same time, providing crude MMA with rather good quality, meaning that MMA concentration in crude MMA is rather high and preferably from 50 wt % to 80 wt %. According to the invention, the esterification unit comprises esterification reactors (1, . . . , 5 (or 6) set up in a serial way so that there is a counter current flow between gaseous phase and liquid phase, the liquid phase flowing from first reactor (1) of the series to last reactor (5 (or 6)), and the gaseous phase flowing from reactor to first reactor (1).Type: ApplicationFiled: October 17, 2014Publication date: September 8, 2016Inventors: Yves BERNARDIN, Romain BILLON, Xavier MARCARIAN, Florent VALLET
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Publication number: 20160257640Abstract: A process for the preparation of substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds which has advantages over conventional processes with respect to higher conversions and yields, flexibility, a shorter overall route, environmentally acceptable conditions, influence of stereoselectivity such as diastereoselectivity in a targeted manner and at least partial suppression of the formation of undesired side-products and/or undesired stereoisomers, in particular undesired diastereomers.Type: ApplicationFiled: May 17, 2016Publication date: September 8, 2016Inventors: Helmut Heinrich BUSCHMANN, Joerg HOLENZ
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Publication number: 20160257641Abstract: The object of the present invention is to provide novel compounds having ACC2 inhibiting activity. In addition, the object of the present invention is to provide a pharmaceutical composition comprising the compound. A compound of formula (I): wherein R1 is substituted or unsubstituted fused aromatic heterocyclyl etc., ring A is substituted or unsubstituted non-aromatic carbocycle etc., -L1- is —O—(CR6R7)m- etc., -L2- is —O—(CR6R7)n- etc., each R6 and R7 are independently hydrogen, halogen etc., R2 is substituted or unsubstituted alkyl, R3 is hydrogen or substituted or unsubstituted alkyl, R4 is substituted or unsubstituted alkylcarbonyl etc.Type: ApplicationFiled: October 17, 2014Publication date: September 8, 2016Applicant: Shionogi & Co., Ltd.Inventors: Naotake KOBAYASHI, Kentarou ASAHI, Yutaka TOMIDA, Masahide OHDAN, Masataka FUMOTO, Yoshikazu SASAKI, Kana KURAHASHI, Takatsugu INOUE, Tomomi URABE, Yuji NISHIURA, Masafumi IWATSU, Keisuke MIYAZAKI, Naoki OHYABU, Toshihiro WADA, Manabu KATOU
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Publication number: 20160257642Abstract: The invention provides compounds for use in treating microbial infection in an animal. Example compounds include Pyridin-3-ylmethyl (4-((2-aminophenyl)-carbamoyl)benzyl)carbamate (“Entinostat”). The compounds can act via induction of the innate antimicrobial peptide defense system, and stimulation of autophagy.Type: ApplicationFiled: October 29, 2014Publication date: September 8, 2016Applicant: AKTHELIA PHARMACEUTICALSInventors: Roger Stromberg, Hakan Ottoson, Birgitta Agerberth, Gudmundur Gudmundsson, Erica Miraglia, Frank Nylen
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Publication number: 20160257643Abstract: The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile.Type: ApplicationFiled: December 28, 2015Publication date: September 8, 2016Inventor: Rao S. Bezwada
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Publication number: 20160257644Abstract: A method includes reacting, at a first pressure and in the presence of a catalyst, ammonia, oxygen, and a hydrocarbon selected from the group consisting of propane, propylene and isobutylene, and combinations thereof, to provide a reactor effluent stream that includes acrylonitrile. The method includes quenching the reactor effluent stream with a first aqueous stream to provide a quenched stream that includes acrylonitrile. The method includes compressing the quenched stream to provide an effluent compressor stream comprising acrylonitrile, and conveying, at a second pressure, the effluent compressor stream to an absorber. The method includes, in the absorber, absorbing acrylonitrile in a second aqueous stream to provide a rich water comprising acrylonitrile, wherein the absorbing is performed at a pressure greater than the first pressure.Type: ApplicationFiled: March 4, 2016Publication date: September 8, 2016Applicant: INEOS EUROPE AGInventors: Timothy Robert McDonel, Jay Robert Couch, David Rudolph Wagner, Paul Trigg Wachtendorf
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Publication number: 20160257645Abstract: Compounds of Formula I with activity against HIV, including pharmaceutical compositions and methods for using these compounds in treating human immunodeficiency virus (HIV) infection, are set forth: Formula: (I)Type: ApplicationFiled: October 23, 2014Publication date: September 8, 2016Inventors: Annapurna Pendri, Guo Li, John A. Bender, Zhong Yang, Alan Xiangdong Wang, Brett R. Beno, Robert A. Fridell, Makonen Belema, Nicholas A. Meanwell, Robert G. Gentles
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Publication number: 20160257646Abstract: The invention relates to a method for synthesising a mercaptan from a terminal olefin and hydrogen sulphide which comprises the following consecutive steps: A—catalytic addition of hydrogen sulphide to a terminal olefin catalysed by an acid catalyst; B—separation of the products of the addition reaction into a light fraction including the surplus hydrogen sulphide and the olefins, and into a heavy fraction including at least one mercaptan and optionally one or more thioethers; C—a finishing step of passing the light fraction obtained in step B over an acid catalyst; then D—separation of the products of the finishing step into a fraction that is rich in hydrogen sulphide and into a fraction that is rich in additives; and finally E—recirculation of the fraction that is rich in hydrogen sulphide to the catalytic addition step A. The invention also relates to the facility for implementing said method.Type: ApplicationFiled: October 22, 2014Publication date: September 8, 2016Applicant: Arkema FranceInventors: Jean-Benoit CAZAUX, Delphine OSTORERO
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Publication number: 20160257647Abstract: The present invention discloses polythiol compositions containing sulfur-containing compounds with carbamate groups, and to methods for producing such polythiol compositions. These polythiol compositions can be synthesized via the reaction of an isocyanate with an allyl ether alcohol, followed by thiolation with H2S, and these polythiol compositions are often used in formulations for adhesives, paints, and coatings.Type: ApplicationFiled: March 3, 2015Publication date: September 8, 2016Inventors: Thomas A. Upshaw, Michael S. Matson
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Publication number: 20160257648Abstract: The present invention relates to new oxindole inhibitors of tyrosine kinase, pharmaceutical compositions thereof, and methods of use thereof.Type: ApplicationFiled: November 9, 2015Publication date: September 8, 2016Inventors: Tadimeti Rao, Chengzhi Zhang
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Publication number: 20160257649Abstract: Dual function compounds are provided that may be inhibitors of histone deacetylase (HDAC) and activators of ataxia telangiectasia mutated (ATM). Pharmaceutical compositions and methods of use are also provided that utilize such compounds.Type: ApplicationFiled: March 3, 2015Publication date: September 8, 2016Inventors: Scott Grindrod, Mira Jung, Milton Brown, Anatoly Dritschilo
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Publication number: 20160257650Abstract: The present invention relates to a selective process for performing the Hartwig-Buchwald coupling of biphenyl derivatives.Type: ApplicationFiled: October 17, 2014Publication date: September 8, 2016Applicant: Umicore AG & Co. KGInventors: Lukas GOOSSEN, Matthias GRUENBERG
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Publication number: 20160257651Abstract: A compound represented by the general formula (I) or a salt thereof having a potent antibacterial activity against bacteria that have acquired resistance to quinolones, and a medicament for prophylactic and/or therapeutic treatment of an infectious disease containing the compound or a salt thereof as an active ingredient, as well as a medicament for prophylactic and/or therapeutic treatment of an infectious disease containing a combination of the compound or a salt thereof, and a quinolone.Type: ApplicationFiled: April 18, 2014Publication date: September 8, 2016Applicant: JUNTENDO EDUCATIONAL FOUNDATIONInventors: Keiichi HIRAMATSU, Yuh MORIMOTO, Tadashi BABA, Isao HAYAKAWA
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Publication number: 20160257652Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.Type: ApplicationFiled: November 10, 2014Publication date: September 8, 2016Inventors: Tesfaye Biftu, Purakkattle Biju, Steven L. Colletti, Qun Dang, Pawan Dhondi, Candido Gude, Hubert Josien, Nam Fung Kar, Anilkumar G. Nair, Ravi P. Nargund, De-Yi Yang, Cheng Zhu
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Publication number: 20160257653Abstract: This invention relates to novel benzazepine dicarboxamide compounds of the formula wherein R1 to R4 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are TLR agonists and may therefore be useful as medicaments for the treatment of diseases such as cancer, autoimmune diseases, inflammation, sepsis, allergy, asthma, graft rejection, graft-versus-host disease, immunodeficiencies, and infectious diseases.Type: ApplicationFiled: March 4, 2016Publication date: September 8, 2016Applicant: Hoffmann-La Roche Inc.Inventors: Sabine Hoves, Lisha Wang, Hongying Yun, Weixing Zhang, Wei Zhu
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Publication number: 20160257654Abstract: A compound, or a pharmaceutically acceptable salt or ester thereof, comprising (i) a CB1 receptor mediating scaffold and (ii) a second therapeutic scaffold.Type: ApplicationFiled: March 4, 2016Publication date: September 8, 2016Applicant: The United States of America, as represented by the Secretary, Department of Health and Human ServInventors: Resat Cinar, George Kunos, Malliga R. Iyer, William A. Gahl, Bernadette R. Gochuico, May Christine Vergara Malicdan
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Publication number: 20160257655Abstract: Antibacterial and antimalarial IspF inhibitor compounds and compositions are described. Methods include administering described compounds and compositions to treat bacterial or parasitic infections and to inhibit parasite or bacterial growth.Type: ApplicationFiled: March 9, 2016Publication date: September 8, 2016Inventors: Timothy J. HAGEN, Zheng ZHANG, Zachary LAZOWSKI, Michael CLARE, Darren W. BEGLEY
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Publication number: 20160257656Abstract: The present invention relates to heterocyclic compounds useful for antagonising angiotensin II Type 2 (AT2) receptor. More particularly the invention relates to piperazine and diazepine compounds, compositions containing them and their use in methods of treating or preventing disorders or diseases associated with AT2 receptor function including neuropathic pain, inflammatory pain, conditions associated with neuronal hypersensitivity, impaired nerve conduction velocity, cell proliferation disorders, disorders associated with an imbalance between bone resorption and bone formation and disorders associated with aberrant nerve regeneration.Type: ApplicationFiled: May 9, 2016Publication date: September 8, 2016Inventors: Thomas David McCarthy, Alan Naylor