Abstract: The present invention provides antibodies that bind to the human glucagon receptor, designated GCGR and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human GCGR. The antibodies of the invention are useful for lowering blood glucose levels and blood ketone levels and are also useful for the treatment of diseases and disorders associated with one or more GCGR biological activities, including the treatment of diabetes, diabetic ketoacidosis, long-term complications associated with diabetes, or other metabolic disorders characterized in part by elevated blood glucose levels, including stress hyperglycemia.

Abstract: There is disclosed compositions and methods relating to or derived from anti-TIM3 antibodies. More specifically, there is disclosed fully human antibodies that bind TIM3, TIM3-antibody binding fragments and derivatives of such antibodies, and TIM3-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating a disease.

Abstract: There is disclosed compositions and methods relating to or derived from anti-JAG1 antibodies. More specifically, there is disclosed fully human antibodies that bind JAG1, JAG1-binding fragments and derivatives of such antibodies, and JAG1-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having JAG1 related disorders or conditions.

Abstract: The invention provides antibodies which bind to LY75. Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided. The antibodies may be used for the treatment of cancer, including pancreatic cancer, ovarian cancer, breast cancer, colorectal cancer, esophageal cancer, skin cancer, thyroid cancer, lung cancer, bladder cancer, multiple myeloma and lymphoma.

Abstract: This invention relates to antibodies that specifically bind HER2/neu, and particularly chimeric 4D5 antibodies to HER2/neu, which have reduced glycosylation as compared to known 4D5 antibodies. The invention also relates to methods of using the 4D5 antibodies and compositions comprising them in the diagnosis, prognosis and therapy of diseases such as cancer, autoimmune diseases, inflammatory disorders, and infectious disease.

Abstract: Provided is a monoclonal antibody which specifically recognizes B cell lymphoma cells and a use thereof. More specifically, provided are the monoclonal antibody; a pharmaceutical composition for preventing or treating B cell lymphoma including the monoclonal antibody; a composition for diagnosing B cell lymphoma including the monoclonal antibody; a method for providing information for diagnosing B cell lymphoma using the monoclonal antibody; a chimeric antigen receptor (CAR) protein including i) the antibody, ii) a transmembrane domain, and iii) an intracellular signaling domain; a recombinant vector which expresses the CAR protein; a CAR-modified T cell transformed with the recombinant vector; a pharmaceutical composition for preventing or treating B cell lymphoma including the CAR-modified T cell; and an antibody-drug conjugate wherein the monoclonal antibody and a drug are conjugated.

Abstract: Provided herein are isolated heteromultimers comprising: at least one single domain antigen-binding construct attached to at least one monomer of a heterodimer Fc region; wherein the heterodimer Fc region comprises a variant CH3 domain comprising amino acid mutations that promote the formation of said heterodimer with stability comparable to that of a native Fc homodimer; and wherein said isolated heteromultimer is devoid of immunoglobulin light chains and optionally devoid of immunoglobulin CH1 region. These novel molecules comprise complexes of heterogeneous components designed to alter the natural way antibodies behave and that find use in therapeutics.

Abstract: The invention relates to glycoengineered antibodies and antibody-conjugates. In particular, the invention relates to an antibody conjugate, prepared from an IgG antibody comprising one N-linked glycosylation site on the combination of a single heavy chain and single light chain, wherein the N-linked glycosylation site is a mutant N-linked glycosylation site as compared to its wild type counterpart. The invention further relates to methods for the preparation of the antibody-conjugates according to the invention.

Abstract: An antibody comprising an antigen recognition region which comprises CDR amino acid sequences set forth in SEQ ID NO: 7, 8, 9, 10, 11 and 12.

Abstract: The invention concerns a process for the manufacture of an acylated polymer composition comprising amylose and/or amylopectin, comprising a pre-treatment step in the presence of an acid, a salt and a polycarboxylic acid, subsequent acylation and, preferably, a post-treatment step with an acid. The products obtained are useful as additives in inks, varnishes, lacquers, coatings, thickeners, adhesives or binders.

Abstract: The invention concerns a process for the manufacture of an acylated polymer composition comprising amylose and/or amylopectin, comprising a pre-treatment step in the presence of an acid, and optionally one additive selected from the group of a hydroxycarboxylic acid and a salt in combination with a polycarboxylic acid. After pre-treatment, the polymer is acylated and, preferably, subjected to a post-treatment step with an acid. The products obtained are useful as additives in varnishes, lacquers, coatings, thickeners, adhesives or binders, and preferably inks.

Abstract: A method of using supercritical fluid technology to separate and purify the functional components of Antrodia cinnamomea is described. Triterpenoids and polysaccharides of Antrodia cinnamomea are extracted from a fractionation tank containing extract of Antrodia cinnamomea and supercritical solvent at a set temperature and pressure. The extracted functional components and supercritical solvent are then continuously fed into three separating tanks at a set temperature and a pressure below that of the aforesaid pressure to obtain various functional components of triterpenoids and polysaccharides from the Antrodia cinnamomea feed in each separating tank.

Abstract: The present invention relates a heteropolysaccharide characterized in that it is substantially composed of the monosaccharides glucose and galactose and rhamnose and N-acetylgalactosamine and a process for the production thereof. The invention further relates to a bacterium capable of producing said heteropolysaccharide and to the use of the heteropolysaccharide and the bacterium for improving the texture of fermented milk products.

Abstract: The invention relates to neodymium-catalysed polybutadienes (NdBR) comprising >95 wt % of cis-1,4 units and <1 wt % of 1,2-vinyl content, based on the neodymium-catalysed polybutadiene, wherein the NdBR evinces a molar mass breakdown of not less than 25%.

Abstract: An intermediate compound for forming a RAFT agent is provided that can have the formula: where n is an integer from 1 to 20; m is an integer from 0 to 20; R1 is H, an alkyl group, or a cyano group; R2 is H, an alkyl group, or a cyano group; Y is OH, COOH, or NH2; and X is OH, COOH, NH2, a nitrobenzyl, benzyl, or para-methyl benzyl group. A RAFT agent is also provided that comprises a thiocarbonylthio-containing organic compound having a phosphonic end group. A method is also provided for forming a polymer chain on a surface of a nanoparticle utilizing the RAFT agent, along with nanoparticles and nanocomposites formed therefrom.

Abstract: The present disclosure relates to catalysts comprising two heterogeneous chromium catalysts for the polymerization of olefins are provided herein. The catalysts, as well as related compositions and methods using the same, may be used to for the production of polyolefins, including for the production of bimodal molecular weight distribution polyolefins, e.g., polyethylene and copolymers of ethylene and 1-hexene.

Abstract: The present invention relates to copolymer rubbers containing nitrile groups and to the preparation thereof, to vulcanizable mixtures comprising copolymer rubbers containing nitrile groups and to the production thereof, and to vulcanizates based on copolymer rubbers containing nitrile groups, to the production thereof and to the use thereof as technical material.

Abstract: Polymeric dispersants are disclosed that include an acrylic backbone at least one pendantly attached imide group, wherein the carbonyl of the imide are chemically bonded to a fused aromatic ring. The aromatic ring can be substituted with various electron withdrawing or releasing groups. Desirably dispersant also includes solvent-solubilising chains of polyether, polyester, polyacrylate, and or polyolefin.

Abstract: The present invention relates to a polyurethane resin including, as constituent units, a diol (a1) having a number average molecular weight of 500 to 10,000, an organic diisocyanate (b), and a chain extender (a2). The total concentration of urethane groups and urea groups in the polyurethane resin is 1.25 to 2.50 mmol/g based on the weight of the polyurethane resin. Hard segment domains of the polyurethane resin have an average domain size of 20 to 30 nm as measured with an atomic force microscope.

Abstract: The present invention relates to a method for producing flexible polyurethane foams, wherein an isocyanate component (component B) is used which comprises polyether carbonate polyol, and to the isocyanate component itself. The invention also provides an NCO-terminated, urethane group-comprising prepolymer obtainable by reaction of one or more polyisocyanates (B1) with one or more polyether carbonate polyols.

Abstract: Implementations described herein relate to an etheramine mixture containing a cyclobutane based amine and its method of production by alkoxylating an initiator with an alkylene oxide to produce a precursor polyol and reductively aminating the precursor polyol to form the ehteramine mixture. The etheramine mixture may be used in a variety of applications including as a curing agent for an epoxy resin or as a reactant in the production of polyurea materials.

Abstract: Implementations described herein generally relate to etheramine mixtures formed from a mixture of two or more multifunctional alcohol initiators, processes for the etheramine mixtures production, and its use as a curing agent or as a raw material in the synthesis of polymers. In one implementation, the process comprises mixing a polyol initiator having a melting point greater than a processing temperature and a polyol initiator having a melting point less than the processing temperature to form a polyol initiator mixture having a melting point less than the processing temperature, charging the polyol initiator mixture to an alkoxylation reaction zone, contacting the polyol initiator mixture with an alkylene oxide in the alkoxylation reaction zone to provide a mixture of alkoxylated precursor polyols and charging the mixture of alkoxylated precursor polyols to a reductive amination zone and reductively aminating the mixture of alkoxylated precursor polyols to form the etheramine mixture.

Abstract: The present invention relates to methods and compositions for olefin metathesis. More particularly, the present invention relates to methods and compositions for ring opening metathesis polymerization (ROMP) reactions and the manufacture of polymer articles and/or polymer composite articles via ROMP Polymer products produced via the metathesis reactions of the invention may be utilized in a wide range of materials and composite applications. The invention has utility in the fields of polymer and materials chemistry and manufacture.

Abstract: The invention relates to a process for synthesizing poly(3,4-ethylenedioxythiophene)-electrolytic (co)polymer composite in a single step.

Abstract: The invention relates to a thermosetting powder coating composition comprising a first resin and a second resin, the first resin being an acid functional polyester resin with an acid value below 50 mg KOH/g, the second resin being obtainable by reacting hydroxyl functional components and acid functional components, the hydroxyl functional components comprising components containing 2 hydroxyl functional groups per molecule and/or components containing at least 3 hydroxyl functional groups per molecule, the acid functional components comprising components containing 2 acid functional groups per molecule and/or components containing at least 3 acid functional groups per molecule, wherein more than 90 mol.

Abstract: Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.

Abstract: The present invention provides methods, processes, and systems for the manufacture of three-dimensional articles of polymer materials using 3D printing. A syringe or an inkjet print head prints a solution of prepolymer onto a build plate. The printed prepolymer is exposed to a stimulus whereby the prepolymer is converted to the polymer. After a predetermined time, sequential layers are printed to provide the three-dimensional article. The three-dimensional article can be cured to produce the 3D article made from the final polymer.

Abstract: Provided are [1] a xylylenediamine composition containing xylylenediamine and 1,2-ditolylethane wherein the content of 1,2-ditolylethane is 0.001 to 0.02 parts by mass based on 100 parts by mass of the xylylenediamine; and [2] a method for producing a polyamide resin including the steps of introducing a diamine containing xylylenediamine, a dicarboxylic acid, and 1,2-ditolylethane into a reaction system and performing polycondensation reaction, wherein the amount of the 1,2-ditolylethane to be introduced is 0.001 to 0.02 parts by mass based on 100 parts by mass of the xylylenediamine.

Abstract: Disclosed herein are monomer embodiments that can be used to make polymers, such as homopolymers, heteropolymers, and that can be used in particular embodiments to make sequence-defined polymers. Also disclosed herein are methods of making polymers using such monomer embodiments. Methods of using the polymers disclosed herein also are described.

Abstract: A degradable downhole tool or component thereof comprising a thiol-based polymer having at least one thiol functional group, wherein the thiol-based polymer is capable of at least partially degrading in a wellbore environment, thereby at least partially degrading the downhole tool or component thereof. The thiol-based polymer may be selected from the group consisting of a thiol-ene, a thiol-yne, a thiol-epoxy, and any combination thereof.

Abstract: An organopolysiloxane emulsion composition having good age stability is prepared by (I) emulsifying a mixture comprising (A) an organopolysiloxane of formula: HO(R12SiO)nH, (B) a surfactant and (C-1) water to form a first emulsion composition and (II) effecting emulsion polymerization of the first emulsion composition in the presence of (D) an acid catalyst below 40° C. The target emulsion composition contains an organopolysiloxane product having a viscosity?300,000 mPa·s at 25° C. and an octamethylcyclotetrasiloxane content 3,000 ppm, and has an emulsified particle size?500 nm.

Abstract: The present application relates to a cured product and the use thereof. When the cured product, for example, is applied to a semiconductor device such as an LED or the like, the decrease in brightness may be minimized even upon the long-term use of the device, and since the cured product has excellent cracking resistance, the device having high long-term reliability may be provided. The cured product has excellent processability, workability, and adhesive properties or the like, and does not cause whitening and surface stickiness, etc. Further, the cured product exhibits excellent heat resistance at high temperature, gas barrier properties, etc. The cured product may be, for example, applied as an encapsulant or an adhesive material of a semiconductor device.

Abstract: A block copolymer containing a first block having a structure represented by general formula (1) shown below (Rs01 and Rs02 each independently represents an organic group, provided that at least one of Rs01 and Rs02 has a polar group; and * represents a valence bond).

Abstract: Provided are a polycarbonate-polyorganosiloxane copolymer having a carbon tetrachloride concentration of less than 4 ppm by mass, and the following production method for producing the polycarbonate-polyorganosiloxane copolymer.

Abstract: The present invention relates to a method for treating lignin, wherein the method comprises the following steps: a) dissolving lignin into an aqueous composition, which contains a compound selected from the class of phenols and alkali, while keeping the temperature of the composition at 40-85° C., wherein the alkali comprises a hydroxide of an alkali metal; and b) heating the composition at a temperature, which is higher than the temperature of the composition in step a), with the proviso that the temperature of the composition does not exceed 100° C., while keeping the pH of the composition at a pH value of 6-14.

Abstract: A composite may include polylactic acid, polyethylene, and optionally a compatibilizer. The composite may be formed by combining the polylactic acid with the polyethylene. The composite may be formed into an extruded article.

Abstract: A carbon fiber-reinforced polyarylene sulfide has both dynamic characteristics and molding cycle characteristics and can be produced with high productivity by preparing a polycarbodiimide-modified polyarylene sulfide using a polyarylene sulfide and a polycarbodiimide as raw materials, then melting the resulting polycarbodiimide-modified polyarylene sulfide, and combining the polycarbodiimide-modified polyarylene sulfide with carbon fibers at a specific ratio to produce a composite.

Abstract: The invention relates to a fibre composite (42) comprising at least one fibre layer (4, 14, 16) composed of a fibre material which is embedded in a matrix (8, 18) based on a thermoplastic, where the composition of the matrix (8, 18) contains: 60-95 parts by weight of aromatic polycarbonate and/or aromatic polyester carbonate and further additives. The invention further relates to the use of such a fibre composite for a component for a rail vehicle, in particular for a rail vehicle for transporting passengers.

Abstract: The present invention relates to an aqueous polyarethaneurea dispersion, wherein the polyurethaneurea has specific formation components, and which is characterized in that it has a content of —COOH groups of at least 0.75% by weight, where 0% to 35% of these groups have been neutralized, and in that 5 to 50 mol % of isocyanate groups present have been reacted with a monofunctional component. The invention further relates to the use of this dispersion as coating composition, to a fibre having a cured coating and to a composite material.

Abstract: Provided is a waterborne adhesive composition comprising (i) an aqueous medium; (ii) one or more isocyanate compounds dispersed in said aqueous medium, and (iii) one or more functional silane compounds dispersed in said aqueous medium. Also provided is a method of bonding a metal foil to a polymeric film comprising the steps of (A) applying a layer of the waterborne adhesive composition to a surface of said metal foil, (B) drying said layer of said adhesive composition to produce a layer of dried adhesive, and (C) after said drying, bringing a surface of a polymeric film into contact with said layer of said dried adhesive composition.

Abstract: A functionalized carbon fiber having covalently bound on its surface a partially cured epoxy or amine-containing sizing agent, wherein at least a portion of epoxide or amine groups in the sizing agent are available as uncrosslinked epoxide or amine groups, which corresponds to a curing degree of epoxide or amine groups of no more than about 0.6. Composites comprised of these functionalized carbon fibers embedded in a polymeric matrix are also described. Methods for producing the functionalized carbon fibers and composites thereof are also described.

Abstract: Provided is a foamable polyamide composition comprising a) at least one polyamide comprising at least one carboxylic group; b) at least one thermoplastic rubber; and c) at least one compound having at least one isocyanate group; and optionally d) at least one filler and e) at least one additive.

Abstract: A formulation for producing a polymeric material including high-density polyethylene, a chemical blowing agent, and other optional components is described.

Abstract: The purpose of the present invention is to provide a novel urethane decomposing method by which urethane in the environment is treated efficiently and at a low cost, and a urethane decomposing agent. The above purpose is attained by employing a urethane decomposing method including: a step of treating a urethane-containing material to be treated using an unsaturated fatty acid; and a step of making a microorganism belonging to a Streptomyces genus and exhibiting urethane decomposing function, to act on the material treated using the unsaturated fatty acid.

Abstract: A method of increasing fire resistance of a synthetic material by bringing the material into contact with a fire retardant composition including boric acid and a salt of boric acid, the fire retardant composition being free from carboxymethylcellulose. A synthetic material of increased fire resistance. A fire retardant composition and a method for preparing a fire retardant composition.

Abstract: Polymeric compositions are provided that include a 1,2,5-pentanetriol trialkylester plasticizer. The plasticizer has low odor, has good compatibility with a variety of polymers such as hydrophilic polymeric materials, and can be formed from renewable resources. Further, the plasticizer can be used at temperatures often encountered during hot melt processing of polymeric compositions.

Abstract: A bioderived based plasticizer is produced by reacting a bioderived diol (and/or a bioderived alcohol) and a bioderived carboxylic acid in the presence of N,N?-dicyclohexylcarbodiimide (DCC), wherein the bioderived carboxylic acid includes a hydrolyzed oil. The bioderived carboxylic acid (e.g., linoleic acid, ?-linolenic acid, oleic acid, and mixtures thereof) may be produced by hydrolyzing a triglyceride, such as canola oil, linseed oil, soybean oil, and mixtures thereof. In one embodiment of the present invention, a bioderived based plasticizer is produced by reacting 2,5-bis-(hydroxymethyl)furan and ?-linolenic acid in the presence of DCC. In some embodiments of the present invention, the bioderived based plasticizer is blended into one or more polymers.

Abstract: A bioderived based plasticizer is produced by reacting a bioderived diol (and/or a bioderived alcohol) and a bioderived carboxylic acid in the presence of N,N?-dicyclohexylcarbodiimide (DCC), wherein the bioderived carboxylic acid includes a hydrolyzed oil. The bioderived carboxylic acid (e.g., linoleic acid, ?-linolenic acid, oleic acid, and mixtures thereof) may be produced by hydrolyzing a triglyceride, such as canola oil, linseed oil, soybean oil, and mixtures thereof. In one embodiment of the present invention, a bioderived based plasticizer is produced by reacting 2,5-bis-(hydroxymethyl)furan and ?-linolenic acid in the presence of DCC. In some embodiments of the present invention, the bioderived based plasticizer is blended into one or more polymers.

Abstract: The present invention relates to a molding composition, a process for the manufacturing of said molding composition, molded parts obtainable therefrom as well as the use of the molding composition for the manufacturing of molded parts used in the automotive industry, for housings, latches, window winding systems, wiper systems, pulleys, sun roof systems, seat adjustments, levers, gears, claws, pivot housing, brackets, wiper arms or seat rails.

Abstract: The present invention relates to a three-dimensional cellulosic molded body that has an optically detectable core/shell structure, the shell having a higher density and a lower crystallinity than the core, and the core having a sponge-like structure. The invention further relates to a method for producing this molded body as well as to its use, especially in the cosmetics and pharmaceutical industries.