Abstract: The invention relates to a flow measurement system for determining a flow of a medium, comprising a Coriolis flow sensor, a thermal flow sensor and a processing unit connected thereto. According to the invention, the processing unit is arranged for determining, based on the output signals of both the Coriolis flow sensor and the thermal sensor, at least one of the thermal conductivity and the specific heat capacity of a medium in the flow measurement system. The invention further relates to a method of determining at least one of the thermal conductivity and the specific heat capacity of a medium.

Abstract: Systems and methods for monitoring microorganisms on a surface are provided. In particular, a flat, patterned sensing electrode can be positioned proximate a surface in non-contact relationship with the surface. The sensing electrode can include a working electrode and a counter electrode. The surface and the sensing electrode can be submerged in an aqueous medium. An alternating current signal can be applied at the working electrode. The signal can propagate through the aqueous medium and can be measured at the counter electrode. The presence of microorganisms on the surface can cause changes in the signal as the signal propagates through the aqueous medium. Such changes in the signal can be used to determine impedance parameters, which can correspond to microbial characteristics associated with the surface. For instance, the microbial characteristics can be associated with a biofilm, corrosion and/or bio-corrosion on the surface.

Abstract: A fluid testing system comprises controlling hardware that serves to control an electric sensor on a fluid testing cassette. In one implementation, the controlling hardware is part of a cassette interface. In another implementation, the controlling hardware is part of the portable electronic device. In one implementation, the fluid testing system applies two different frequencies of alternating current are applied to two different electric sensors.

Abstract: A sensor for measuring conductivity of a fluid containing dissolved ions, particularly for measuring conductivity of salt water, features a cylindrical tube (57) of poorly conductive material such as glass, a first electrode (51A) and a second electrode (51B) inside the tube, connected together (56) to maintain a common electrical potential, a first transformer (52,53) concentrically arranged around the tube (57) to drive current through the fluid in the tube, and a second transformer (54, 55) arranged to sense a value of the current flowing in the fluid, and a digital processing circuit (62) coupled to receive an output signal of the second transformer, and to derive therefrom a value representing the conductivity of the fluid. The sensor is adapted to be towed behind a research ship, or to be deployed on an autonomous underwater vehicle (AUV) or the like. Current signals are preferably processed by digital switching measurement technology (dMST).

Abstract: A sensor system for detection of an analyte in an industrial fluid in the presence of interferences which includes: a multivariable inductor-capacitor-resistor resonant transducer with multiple operationally independent outputs; a sensing material composition configured to provide different response patterns to an analyte in the fluid in the presence of interferences; and a signal processor that quantifies the analyte. Also, a sensor system for detection of an analyte that includes: a transducer with multiple operationally independent outputs; a sensing material compositions configured to provide different response patterns to an analyte in the industrial fluid in the presence of interferences; and a signal processor configured to quantify the analyte in the industrial fluid in the presence of interferences. An embodiment of the sensor system detects methane.

Abstract: A humidity sensor that includes a humidity sensitive material. A sensing circuit associated with the humidity sensitive material estimates the ambient humidity based upon the humidity sensitive material. A heating element is associated with the humidity sensitive material. A temperature circuit increases the temperature proximate the humidity sensitive material and thereafter the sensing circuit estimates the ambient humidity.

Abstract: The disclosure includes a control method for test strip electrodes. The method can include inserting a test strip into a glucose meter and applying a predetermined voltage to the working electrode W of the test strip. The Method can also include applying a sample to the test strip and acquiring real-time data of current generation at the electrodes R1 and R2 of the test strip. Some embodiments can also include determining whether the electrode R1 generates current earlier than the electrode R2 or not.

Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

Abstract: A cavity in which an analysis sample is held and measurement is performed, and an electrode system for measuring the concentration of the sample in the cavity are provided on a biosensor. A secondary cell and an environment temperature sensor are provided inside the measuring device. The environment temperature during charging is measured in real-time by specifying the environment temperature during charging from the time required to charge the secondary cell and the environment temperature during charging. The measured analysis sample concentration is corrected for temperature with high accuracy from the environment temperature information obtained during charging, and thus an analysis result with extremely high accuracy is obtained.

Abstract: There is provided an electrolyte measuring device that can decrease a liquid amount used for measurement, in which stable sealing can be provided in connecting passages of ion selective electrodes to each other with no gap, while maintaining high measurement accuracy of an existing ion selective electrode, and a residing sample liquid can be greatly decreased. In a flow-type ion selective electrode, a sealing member is used, which can be brought into intimate contact with a passage connecting unit to near a passage hole. A gap regulating member is provided to keep a gap between the electrodes constant and to prevent the sealing member from being excessively pressed. An electrode case has a structure suitable for the sealing member for allowing the alignment and holding of the sealing member.

Abstract: Disclosed are a gas sensor member, a gas sensor using the same, and manufacturing methods thereof, and specifically, a gas sensor member using a one-dimensional porous metal oxide nanotube composite material having a double average pore distribution in which mesopores (0.1 nm to 50 nm) and macropores (50 nm to 300 nm) are simultaneously formed on the surface of a nanotube through decomposition of a spherical polymer sacrificial template and continuous crystallization and diffusion of a metal oxide and a nanoparticle catalyst embedded in an apoferritin is uniformly loaded in the inside and on the outer wall and inner wall of a one-dimensional metal oxide nanotube through a high-temperature heat treatment, a gas sensor using the same, and manufacturing methods thereof are disclosed.

Abstract: A gas sensor element which has water-permeable electrodes, and water-impermeable leads connected to the electrodes A first electrode (133) has a space exposure portion (133b) exposed to internal space (160) of a gas sensor element (10) which communicates with an ambient atmosphere. A first lead (137) is connected to the first electrode (133). The first electrode (133) includes a first connection portion (133d) which is disposed at a position not exposed to the internal space (160) and connected to the first lead (137), and which is a portion of the first electrode (133) located most distant from the internal space (160). The entire first connection portion (133d) is located in a region A1 which extends from the internal space (160) over a distance of 1.0 mm or less. Also enclosed is a gas sensor including the gas sensor element.

Abstract: A sintered electrically conductive oxide for an oxygen sensor electrode includes a crystal phase formed of a perovskite-type electrically conductive oxide containing at least La, Fe and Ni. The oxide has an absolute value of thermoelectromotive force at 770° C. of 21.0 ?V/K or less.

Abstract: A device layer of an integrated circuit device includes a semiconductor active layer spanning a plurality of device regions. Each of the device regions has a heating element, a temperature sensor, and bioFETs in the device layer. The bioFETs have source/drain regions and channel regions in the semiconductor active layer and fluid gates exposed on a surface for fluid interfacing on one side of the device layer. A multilayer metal interconnect structure is disposed on the opposite side of the device layer. This structure places the heating elements in proximity to the fluid gates enabling localized heating, precision heating, and multiplexed temperature control for multiplexed bio-sensing applications.

Abstract: Methods that allow independently applied pressures to a BGE reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used. The methods are particularly suitable for use with a mass spectrometer.

Abstract: There are provided (i) a gel for use in polyacrylamide gel electrophoresis which gel produces a concentration effect for a longer time period and prevents heat generation during migration and (ii) an electrophoresis apparatus provided with the gel. A gel according to the present invention for use in polyacrylamide gel electrophoresis includes a concentration gel and a separation gel having a pH adjusted to a value different from the pH value of the concentration gel, an acrylamide buffer being covalently bonded to at least one of the concentration gel and the separation gel.

Abstract: A cassette for use in parallel electrophoretic assays and methods of manufacture and use of same are provided. The cassette comprises assay channels suitable for carrying out electrophoresis and sample ports for introducing samples into the assay channels. Each sample port comprises one or more tip registration features for guiding a pipette tip to a desired location, which corresponds to the position of a well for receiving the sample. The cassette is particularly suited for use with automated liquid handling systems.

Abstract: This disclosure provides systems, methods, and apparatus related to few-layer and monolayer hexagonal boron nitride having a pore therein. In one aspect, a method comprises providing a sheet of hexagonal boron nitride (h-BN). A defect is created in the sheet of h-BN. The sheet of h-BN is heated to a temperature above about 500° C. The defect in the sheet of h-BN is irradiated with charged particles to enlarge the defect to a hexagonal-shaped pore or a parallelogram-shaped pore in the sheet of h-BN.

Abstract: An analytical tool for use in analysis of a sample is provided. The analytical tool includes a first unit and a second unit. The first unit has an analysis portion where analysis is performed. The second unit, configured to be coupled with the first unit, has a liquid reservoir for confining a particular liquid used for the analysis of the sample. When the first unit and the second unit are coupled, a fluid passage for conducting the particular liquid from the liquid reservoir into the first unit is formed by only a part of the first unit, or only a part of the second unit, or a combination of respective parts of the first unit and the second unit.

Abstract: Use a pair of U-shaped doorframe (with U-shaped rubber sealing gaskets affixed along them) to divide the inside of a transparent ark into 3 compartments. Develop out a telescopic pushing tool. Place it into the middle compartment, and then use it to force 2 pieces of vertical slice gel cassette to rest against the 2 door frames respectively, so as to transform the 3 compartments into 3 water-tight compartments. Wherein, the 2 side 2 are the 2 upper buffer chambers of the present electrophoresis cell. This kind of electrophoresis cell has only 2 necessary components, and it can be made to be compatible with all of those so called mini gel cassettes with different thicknesses and/or heights.

Abstract: A method and apparatus for performing differential mobility spectrometer (DMS) which includes decreasing the amount of time that ions spend inside fringing fields generated by the DMS. The apparatus includes an entrance electrode plate sealingly engaged to the entrance of the DMS, and is electrically separated from the parallel plate electrodes of the DMS, the entrance electrode plate has an aperture for allowing the traversal of ions into the DMS; wherein the cross-sectional area of the aperture is less than the cross-sectional area of the ion path, the ion path being located between the two parallel plate electrodes of the DMS. The entrance electrode plate may also have a focusing potential applied to it for focusing of ions.

Abstract: Provided are magnetic sensors, which include a magnetic sensor element having a sensor surface modification and an inter-element area adjacent to the magnetic sensor element and having an inter-element area surface modification, where the sensor surface modification and the inter-element area surface modification provide a binding surface in the inter-element area. Also provided are devices, systems and methods in which the subject magnetic sensors find use.

Abstract: The invention relates to a method for determining the proportion of molecular oxygen in a respiratory gas, for example in lung function diagnostics, comprising the introduction of the respiratory gas into a measurement tube, transmitting a sound signal by means of a sound transmitter and receiving the sound signal by means of a sound receiver, defining a sound measurement zone by means of the sound transmitter and the sound receiver, determining the average molar mass of the respiratory gas by means of a sound propagation time measured over the measurement zone, and determination of the carbon dioxide content of the respiratory gas with a carbon dioxide gas sensor. The invention also relates to a device for performing the method.

Abstract: A method and system are described for examining the interior material of an object from a surface of an object using ultrasound having a frequency of at least 100 kHz. The method comprises the step of transmitting at least a first ultrasound signal by a first ultrasound transmitter of a first number of ultrasound transmitters to the interior material of the object for forming a first image in order to determine, according for example to the principle of inverse wave field extrapolation, where in the interior material of the object reflections and/or diffractions occur. Reflections and/or diffractions of the first ultrasound signal from the interior material of the object are received using a second number of ultrasound receivers which are acoustically coupled to the surface of the object at positions which are distributed in at least one dimension of the surface of the object.

Abstract: A device for ultrasound tests, includes one or more transducers for generating ultrasound beams with different powers/frequencies to be projected in direction of multiple targets, to ensure separate control of the temperature both of the targets and of the transducers and allows performing several tests contemporarily, by optimizing the functionality and the efficiency of the device, and guaranteeing results comparable therebetween for each test.

Abstract: A through-transmission ultrasonic (TTU) inspection system for ultrasonic inspection of a part, such as an aircraft component. The TTU inspection system may include a first end effector and/or a second end effector. The first end effector may be positioned on a first surface of the part and the second end effector may be positioned on a second surface of the part, opposite the first surface. The first and/or second end effector may also include an acoustic coupling medium encircled by a plurality of pins independently movable toward and away from a housing of the first and/or second end effector, such that the pins may follow local part contours along the first surface at all times, while retaining the acoustic coupling medium between the first surface and a transducer in the housing of the first and/or second end effector.

Abstract: A method for analyzing and quantifying a panel of drugs in a clinical sample comprises: trapping a first portion of drug parent compounds and their metabolites on a first chromatographic column; trapping a second portion of the drug parent compounds and their metabolites on a second chromatographic column; separately eluting the first and second portions of the drug parent compounds and their metabolites from the first and second chromatographic columns; detecting concentrations of each of the drug parent compounds and metabolites eluted from each of the first and second chromatographic columns with a detector; and summing the detected concentration of each drug parent compound together with the detected concentrations of all of its respective analytes so as to derive a respective total concentration of each drug in the sample.

Abstract: A thermal conductivity detector includes a heatable resistive detector configured to be physically arranged in an analytes flow eluting from a chromatography column and electrically arranged with resistors in separate arms of a measuring bridge, an amplifier which detects differential voltage between two opposite nodes of the bridge and applies an output voltage to other opposite nodes of the measuring bridge to maintain the detector at a constant operating temperature, and an additional resistor with a controllable switch in parallel connected in series with the detector or resistor arranged in one arm of the bridge, where the switch is periodically turned on and off at a predetermined duty cycle and/or controlled by information on characteristic times-of-arrival of analytes at the detector to compensate for operating temperature uncertainties due to manufacturing variations of the resistors and/or to allow for processing small and large peaks of a chromatogram with highest available resolution.

Abstract: An apparatus used for the surface examination of components. The apparatus comprises: a radiation source configured to convert at least one non-volatile substance at least partially into a gas by irradiating a sample surface of a component; and a detector unit configured to qualitatively and/or quantitatively detect the at least one substance converted into gas. A method provided for a surface examination of components. The method comprises irradiating a sample surface of a component with a radiation source configured to convert at least one non-volatile substance at least partially into a gas; and a qualitative and/or quantitative detection of the at least one substance converted into gas via a detector unit.

Abstract: Embodiments relate generally to systems and methods for determining the location of a gas detector device, wherein the location may be within a predefined location zone, and automatically configuring the gas detector device based on the location zone. Each location zone in a facility may be associated with a configuration for the gas detector device. The location of the gas detector device may be monitored by a central station, and when it is determined that a gas detector device has moved from one location zone to another, the configuration of the gas detector device may be updated accordingly. Additionally, other parameters may be monitored by the central station and/or the gas detector device to determine the appropriate configuration of the gas detector device.

Abstract: A hazard detector includes a chassis configured to house components of the hazard detector. The chassis includes a front defining a central aperture. The front has a domed contour such that an outer edge of an inner portion extends beyond an outer periphery of the front. The inner surface tapers from the outer edge toward the inner portion. The detector includes a mesh formed to the contour of the front so the mesh is flat against the front. The mesh defines an aperture corresponding to the central aperture. The detector includes a grille secured to the chassis that defines an aperture corresponding to the central aperture and defines openings positioned along the grille. An inner surface of the grille includes a contour corresponding to the contour of the front so the mesh is flat against the inner surface. The mesh is positioned between the grille and the chassis.

Abstract: A method for testing a component for contamination. The method comprises a heating of a specimen surface of the component under a measuring bell defining a measurement volume, an at least two-time measuring of a contamination of the measurement volume with at least one contaminant, and a purging of the measurement volume with gas. An apparatus for testing a component for contamination is also disclosed. The apparatus comprises a measuring bell configured to form a measurement volume about the component or contacting the component. A heating element is configured to heat at least one specimen surface of the component. A purging unit is configured to purge the measurement volume with gas. A sensor system is configured to measure a contamination of the measurement volume with at least one contaminant.

Abstract: A device for measuring the concentrations of volatile organic compounds (VOCs) in air. The device includes a sample chamber for accepting a sample of air; at least one ionization source for ionizing VOCs in the sample; an ionic liquid trap containing an ionic liquid that captures the ionized VOCs; a circuit for generating a electric current through the device to run the ionization and capture of the ionized VOCs; and a chemical sensor for detecting and measuring concentrations of the VOCs in the sample of air. The device, which may be hand-held, portable, or designed to sit on a bench top, may be used on any animal, including humans.

Abstract: Methods are provided for selecting optimal operating conditions for the hydrodesulfurization of a liquid hydrocarbon feed in a reactor. According to one aspect, a desired sulfur content of the product stream is selected. The carbazoles content of a first liquid hydrocarbon feed is measured, and a reaction order for the first liquid hydrocarbon feed is calculated based on the measured carbazoles content. An operating severity index based on the calculated reaction order is then calculated. According to one aspect, the operating severity index comprises an operating temperature of the reactor to yield the product stream with the desired sulfur content from the first liquid hydrocarbon feed. According to another aspect, the carbazoles content of a plurality of liquid hydrocarbon feeds are measured to generate a database of the measured carbazoles content.

Abstract: The apparatus (1) is used for forming a ball of yarn. It contains a container (2) having an internal volume (21) which is outwardly bounded in the vertical direction partially by an internal wall (31) and in the horizontal direction completely by the internal wall (31). The internal wall (31) has an inlet opening (41) through which the yarn is injectable into the internal volume (21) by means of an air flow. The internal wall (31) is rigid. The internal volume (21) has a downwardly open outlet opening (22) for a yarn ball formed in the internal volume (21). A lower part (33) of the internal wall (31) is inclined downwardly towards the outlet opening (22). By virtue of the rigid construction, the apparatus is simple and cost-effective. Possible problems with moving parts are avoided.

Abstract: The present invention provides a method for determining differentiation level of pluripotent stem cell, comprising a step of determining a flatness of cultured pluripotent stem cell, wherein the flatness is an indication.

Abstract: Graphical representation of glycemic variation and average blood glucose values. The invention comprises storing in a memory a series of blood glucose values measured over a period of time; determining, using a processor, a variation value for the series of blood glucose values during the time period based on a standard deviation of the series of blood glucose values; plotting points using the processor for each of the blood glucose values around a center point where the radial distance from the center point to each point to be plotted is determined based on the variation value and a blood glucose value of the point to be plotted, and outputting to a display operative coupled to the processor, a graphical representation of the plotted series of blood glucose values and an indicia representative of the variation value.

Abstract: Described is a personal device and methods for measuring the concentration of an analyte in a sample of gas. The device and method may utilize a chemically selective sensor element with low power consumption integrated with circuitry that enables wireless communication between the sensor and any suitable electronic readout such as a smartphone, tablet, or computer. In preferred form, the sensor circuitry relies upon the quantum capacitance effect of graphene as a transduction mechanism. Also in preferred form, the device and method employ the functionalization of the graphene-based sensor to determine the concentration of nitric oxide in exhaled breath.

Abstract: An apparatus is provided for sensing an analyte in a fluid.

Abstract: A basket for use with a fluidics device for simulating in vivo membrane permeation and response is provided. The basket includes an impermeable surface defining a bottom aperture for positioning within the host fluid of the dosing well of the fluidics device. Further, the basket further includes a permeable membrane positioned within the basket and covering the bottom aperture. Additionally, the basket includes a layer covering at least a portion of the membrane covering the bottom aperture for exposing a bottom side of the layer to the host fluid and for preventing an opposing top side of the layer from being exposed to the host fluid. A dose may be placed in contact with the layer for analyzing downstream permeations and responses.

Abstract: The present invention relates to a method for screening an anticancer agent or a cancer preventive agent, comprising the steps of: (a) isolating mutant luterial or normal luterial from a body fluid extracted from a patient or a normal person; (b) treating the isolated mutant luterial with anticancer agent candidates or cancer preventive agent candidates; and (c) either selecting, as the anticancer agent, a candidate that reduces the size or changes the shape or increases the mobility of the mutant luterial, compared to the control mutant luterial upon treatment with the candidate, or selecting, as the cancer preventive agent, a candidate that suppresses the increase in size, minimizes the change in shape or maintains the mobility of luterial, compared to the control luterial, upon treatment with the candidate.

Abstract: Disclosed are methods and systems for testing the effects of various morphogens and/or feeder cells on the differentiation of pluripotent cells. The assays described herein can be used for determining the optimum conditions that lead to differentiation of stem cells. Once the optimum conditions for stem cell differentiation are determined, such cells may be used in a variety of therapies.

Abstract: The present embodiments relate to selection of agents effective in reducing or preventing gastrointestinal pain in a subject. Such an agent is selected and identified if it is capable of reducing spontaneous and/or induced transient receptor potential vanilloid 1 (TRPV1) activation.

Abstract: A method of qualifying whether a cell population is a suitable therapeutic is disclosed. The method comprises: (a) incubating a population of undifferentiated mesenchymal stem cells (MSCs) in a differentiating medium comprising basic fibroblast growth factor (bFGF), platelet derived growth factor (PDGF), heregulin and cAMP for at least two days to obtain a population of differentiated MSCs; and (b) analyzing the expression of CD49a in the differentiated MSC population, wherein an amount of CD49a above a predetermined level indicative of the cell population being suitable as a therapeutic.

Abstract: Fluorescent quinolizinocoumarin compounds substituted with electrophilic reactive groups that bind thiol compounds are described. The compounds are useful in detecting oxidative stress and processes associated therewith in live cells.

Abstract: Methods are disclosed for identifying one or more proteins or polypeptides comprised by a sample. The methods comprise determining binding of each polypeptide with respect to each binding pool of a plurality of binding pools, wherein each binding pool comprises one or more probes which bind a structure comprised by a protein or polypeptide. In some aspects, polypeptides can be denatured and separated into individual polypeptide strands and immobilized on a solid support prior to determining binding of the binding pools. A protein, polypeptide or polypeptide strand can be identified by searching, in at least one database, for a protein or polypeptide sequence comprising binding pool targets either identical to or most similar to the binding pool targets comprised by the protein, polypeptide or polypeptide strand to be identified. Kits for identifying proteins, polypeptides and polypeptide strands are also disclosed.

Abstract: A method for forming a hydration layer/lipid bilayer structure on a solid support is provided. The method includes contacting a solution comprising at least one polar lipid and a water-miscible alcohol as a solvent with the solid support; and adding water to said solution at a predetermined rate, thus inducing formation of a hydration layer on the solid support surface and formation of a planar lipid bilayer on the hydration layer, wherein the hydration layer has an average thickness of at least 2 nm as well as the thus obtained solid supports with a hydration layer/lipid bilayer structure.

Abstract: In various aspects and embodiments, the present invention is directed to versatile, label-free method for the quantitative and qualitative detection of biomarkers and/or other compounds in a fluid sample using functionalized microparticle aggregates. In these methods, micron-scale particles are functionalized to specifically interact with the biomarker being measured and added to the sample to form aggregates, the size and number of which are counted to find a volume fraction and/or number fraction of aggregates in the sample. There is a direct correlation between the volume fraction and number fraction of these aggregates and the concentration of the corresponding biomarker. By comparing the measured volume fraction and/or number fraction of aggregates in the sample to a calibration curve, the concentration of that biomarker may be determined even for biomarkers or other target compounds in samples at very low concentrations, without the need for fluorescence and enzyme labelling of antibodies.

Abstract: This invention provides a nanozyme immunochromatographic detection method for detecting a substance to be tested in a liquid sample, comprising, in this order, the steps of: 1) providing a detection probe, which is prepared by coupling a magnetic nanoparticle to a first molecule capable of specifically binding to the substance to be tested; 2) providing a capture probe, which is an immobilized second molecule capable of specifically binding to the substance to be tested; 3) bringing the liquid sample into contact with the detection probe; 4) bringing the liquid sample, which has been in contact with the detection probe, into contact with the capture probe; and 5) adding a hydrogen-donor substrate and a peroxide to the capture probe subject to the step 4) so as to perform color development reaction. This invention further provides a nanozyme immunochromatographic detection apparatus for detecting a substance to be tested in a liquid sample.

Abstract: Disclosed herein are compositions and methods for exosome detection with high sensitivity by using a nano-plasmonic sensor. The nano-plasmonic sensor comprises a plurality of nanoapertures suitable for transmission measurements. The detection sensitivity is on the order of 104-fold higher than western blotting and 102-fold higher than enzyme-linked immunosorbent assay (ELISA). A portable imaging system is also disclosed, enabling rapid and high-throughput detection of exosomes. The nano-plasmonic sensor and imaging system can be useful in diagnostics.