Patents Issued in December 8, 2016
  • Publication number: 20160356751
    Abstract: An apparatus is disclosed comprising an intake, configured to be coupled to a vapor device, a pump coupled to the air intake, configured for drawing vapor from the vapor device via the intake, a sensor, coupled to the pump, configured for detecting a condition of the drawn vapor, and a processor, configured for collecting data related to the condition of the drawn vapor from the sensor.
    Type: Application
    Filed: June 8, 2016
    Publication date: December 8, 2016
    Inventor: Jonathan Seamus Blackley
  • Publication number: 20160356752
    Abstract: Methods, systems, and computer-readable media for monitoring a gas are generally described. In some embodiments, the concentration of a gas may be predicted based on gas measurement information received from a gas sensor and gas sensor response information for the gas sensor. The gas sensor response information may include a response curve. In some embodiments, the response curve may include a curve generated based on a Sigmoid function and/or a curve of the first derivative thereof. In some embodiments, the predicted gas measurement value may be generated by predicting an asymptotic value of the gas measurement information based on a rate of change of the concentration of the gas and the response curve.
    Type: Application
    Filed: December 22, 2014
    Publication date: December 8, 2016
    Inventor: Christopher Todd Yocum
  • Publication number: 20160356753
    Abstract: A sensor control apparatus controls a gas sensor including an electromotive force cell (a detection cell) and an oxygen pump cell. The sensor control apparatus includes an AD conversion section (31); a PID computation section (61); a first signal generation section (63) which generates a DAC control signal S1 (a pump current control signal) based on the results of PID performed by the PID computation section (61); a current DA conversion section (35); and a first signal generation section (63), a second signal generation section (65), and a signal output section (67) configured to selectively set a combination of the results of the computations performed by the PID computation section (61) and to generate a gas detection signal S2 based on the set combination of the computation results.
    Type: Application
    Filed: May 31, 2016
    Publication date: December 8, 2016
    Applicant: NGK SPARK PLUG CO., LTD.
    Inventor: Yuzo HIGUCHI
  • Publication number: 20160356754
    Abstract: A freshness indicating medium includes a base member having a first region and a second region. Both the first and second regions contain a reactive material that changes a state thereof by reaction with a food-derived material that is generated as the food product putrefies, such that, as an amount of the food-derived material increases, the reactive material in the first region changes the state before the reactive material in the second region does.
    Type: Application
    Filed: August 18, 2016
    Publication date: December 8, 2016
    Inventors: Ryozo AKIYAMA, Kenichi KOMIYA, Daisuke ISHIKAWA, Ryuichi ARAI, Naoko FUTAMI
  • Publication number: 20160356755
    Abstract: A method of sensing parameters in a fluid distribution system includes the steps of receiving, at a monitoring device, fluid parameter information from a sensor in a fluid distribution system; collecting, by the monitoring device, sampling data of the fluid parameter information from the sensor based on predetermined criteria; receiving, by the monitoring device, a request to collect transient data from the sensor; collecting, by the monitoring device, transient data of the fluid parameter information from the sensor based on predetermined criteria; and communicating the sampling data and the transient data to another device.
    Type: Application
    Filed: June 2, 2016
    Publication date: December 8, 2016
    Inventors: Paul Gifford, Timofey Sitnikov, Harold Mosley
  • Publication number: 20160356756
    Abstract: The present invention provides methods for determining the toxicity of fresh-water and marine sediments and sediment pore water containing indigenous or introduced toxicants from each as a one-time analysis and/or for analysis over a period of time. The present invention further provides kits assembled for the afore-mentioned determination. The methods and kits of the present invention can be used for analyzing sediment and pore water samples from, among other locations, all environments where species having a dormant life stage may exist including, for example, natural zooplankton.
    Type: Application
    Filed: June 2, 2016
    Publication date: December 8, 2016
    Applicant: University of North Carolina Wilmington
    Inventor: Joseph A. Covi
  • Publication number: 20160356757
    Abstract: The current apparatus and method relate to a process for determining the amount and type of organic contaminants in industrial process fluids. The current process enables an industrial plant to quickly analyze the process fluid and thus control the amount of deposition that takes place on the surfaces of equipment in contact with the process fluid.
    Type: Application
    Filed: June 3, 2015
    Publication date: December 8, 2016
    Inventors: Fushan Zhang, Terry Lynn Bliss, Sarah D. Garchinsky
  • Publication number: 20160356758
    Abstract: A non-destructive testing system for propellant for a rocket is provided. The system includes an insertion tube having a first end and a second end in addition to a support sleeve configured to mate with a casing of the rocket. The insertion tube includes a channel that extends from the first end to the second end of the insertion tube to receive a probe and also includes a probe tip generally disposed at the second end of the channel. The support sleeve includes an insertion tube opening configured to receive the insertion tube and allow the insertion tube to slide along the support sleeve.
    Type: Application
    Filed: June 4, 2015
    Publication date: December 8, 2016
    Inventor: Sami Daoud
  • Publication number: 20160356759
    Abstract: The present invention relates to a system of analysis, which can be used in a mobile laboratory in a drilling site situation or in a similar situation, suitable for measuring (preferably in relation to at least two partially gaseous species, which derive preferably from a mixture extracted from a drilling mud, for example, methane, ethane, propane and/or any other heavier hydrocarbons) the quantities of the different isotopes of at least a same chemical element (preferably the quantities of 13C, carbon isotope with 6 protons and 7 neutrons, and of 12C, carbon isotope with 6 protons and 6 neutrons, respectively) by means of a laser isotopes analyser regulated for a single, at least partially gaseous species which contains said chemical element.
    Type: Application
    Filed: August 15, 2016
    Publication date: December 8, 2016
    Inventor: Antonio CALLERI
  • Publication number: 20160356760
    Abstract: Methods of characterizing ion-exchanged chemically strengthened Li-containing glasses include: a) measuring a mode spectrum of the glass sample; b) using the mode spectrum, estimating a first contribution to the center tension associated with a spike region and estimating a second contribution to the center tension due to a deep region only, wherein the deep region is assumed to follow a power-law stress profile; and c) determining a total center tension by adding of the first and second contributions to the center tension. The methods can be used for quality control during manufacturing of glass samples by comparing the total center tension to a center tension specification that provides optimum strength and durability.
    Type: Application
    Filed: June 2, 2016
    Publication date: December 8, 2016
    Inventors: Rostislav Vatchev Roussev, Vitor Marino Schneider
  • Publication number: 20160356761
    Abstract: A single-cell-based electromechanical method for cancerous state detection including the steps of preparing a suspension of individually suspended biological cells, extracting a single cell from the suspension, holding the extracted single cell from the suspension, measuring a first electrical response of the held single cell, step-wised mechanical aspirating the held single cell to form a mechanically deformed cell, and measuring an electrical response of the held single cell after each step of mechanical aspirating. The cancerous state of the single cell is determined based on the changes in the measured electrical responses.
    Type: Application
    Filed: August 17, 2016
    Publication date: December 8, 2016
    Inventors: Mohammad Abdolahad, Ali Saeidi, Milad Gharooni
  • Publication number: 20160356762
    Abstract: The methods disclosed herein relate to an improved tool incorporating platelet count into a multi-biomarker based outcome risk stratification model for evaluating mortality risk in pediatric patients having sepsis. The methods described here are useful for treating sepsis, for point of care clinical decision support, for stratifying septic shock patients based on baseline mortality risk, and for clinical trial design, among other uses.
    Type: Application
    Filed: June 2, 2016
    Publication date: December 8, 2016
    Inventor: Hector R. Wong
  • Publication number: 20160356763
    Abstract: A method of determining whether a patient has taken a dose of medication. The method includes including a first-pass tracer substance with at least one dose of the medication. The first-pass tracer substance is detectable in a body of the patient using a sensor. In addition, the first-pass tracer substance has a short half-life at the site of detection in the body. Further, processing circuitry determines that the patient has taken the dose of medication when the first-pass tracer substance is detected using the sensor at a time after a scheduled medication administration.
    Type: Application
    Filed: June 1, 2016
    Publication date: December 8, 2016
    Inventor: Barry L. JENKINS
  • Publication number: 20160356764
    Abstract: Systems, apparatus and methods determine the presence of a volatile substance in expired breath. Alcohol concentrations can be determined from expired breath through the use of electromagnetic detection. The systems, apparatus and methods allow measurements of volatile substances to be done accurately and quickly over a wide range of temperatures, and are easily incorporated into vehicles.
    Type: Application
    Filed: April 5, 2016
    Publication date: December 8, 2016
    Inventors: Hans Göran Evald Martin, Henrik Rödjegård, Jan-Åke Henning, Pavel Zyrianov
  • Publication number: 20160356765
    Abstract: Coating compositions are described that include one or more rare metal components, such as rare alkali metal components, as well as diagnostics test elements that incorporate the same. Methods also are described for determining an amount of a dried coating composition in a coat based upon the rare metal components.
    Type: Application
    Filed: July 19, 2016
    Publication date: December 8, 2016
    Inventors: Wolfgang Schick, Alexander Ibach, Yilmaz Isgoeren, Kai Kuellmer
  • Publication number: 20160356766
    Abstract: The present invention provides a hapten derivative and conjugate of a natural high intensity sweetener containing hydroxyl groups. The conjugate can be used to produce antibodies specific against the natural high intensity sweetener. The present invention further provides a kit and method for detecting and quantifying the natural high intensity sweetener in a sample.
    Type: Application
    Filed: August 22, 2016
    Publication date: December 8, 2016
    Inventors: Jose Antonio GABALDON HERNANDEZ, Estrella Nunez Delicado, Rosa Puchades Pla, Angel Maquiera Catala, Eva Maria Brun Sanchez, Avetik Markosyan
  • Publication number: 20160356767
    Abstract: The present invention discloses, inter alia, methods for labeling a target protein with an SHG-active probe for detection by second harmonic or sum-frequency generation in order to identify agents which bind to an allosteric site on the target protein thereby altering its structural conformation
    Type: Application
    Filed: June 3, 2016
    Publication date: December 8, 2016
    Inventor: Joshua S. SALAFSKY
  • Publication number: 20160356768
    Abstract: The present invention discloses, inter alia, methods for labeling a target protein with an SHG-active probe for detection by second harmonic or sum-frequency generation in order to identify agents which bind to an allosteric site on the target protein thereby altering its structural conformation
    Type: Application
    Filed: June 3, 2016
    Publication date: December 8, 2016
    Inventor: Joshua S. SALAFSKY
  • Publication number: 20160356769
    Abstract: A piezoelectric plate sensor comprising a piezoelectric layer; two electrodes; and an insulation layer. The insulation layer is produced by soaking the piezoelectric layer and two electrodes in a mercaptopropyltrimethoxysilane solution with an amount of water from 0.1 v/v. % to about 1 v/v % and at pH from about 8 to about 150 for a period from about 8 to about 15 hours, and the mercaptopropyltrimethoxysilane solution has a concentration of mercaptopropyltrimethoxysilane from about 0.01 v/v % to about 0.5 v/v %. A method of detecting a biomolecule in a sample using the piezoelectric plate sensor in particular, that of detecting a genetic marker with PCR sensitivity and specificity without the need of DNA isolation or amplification is also provided. The piezoelectric plate sensor may be used to diagnose various diseases including breast cancer, myocardial infarction, diarrhea, Clostridium difficile infection, and hepatitis B infection.
    Type: Application
    Filed: December 19, 2014
    Publication date: December 8, 2016
    Applicant: Drexel University
    Inventors: Wan Y. Shih, Wei Wu, Wei-Heng Shih, Mehmet Cagri Soylu, Haitao Guo, Suresh G. Joshi, Ceyhun Ekrim Kirimli, Ying-Hsiu Su
  • Publication number: 20160356770
    Abstract: The present invention concerns a device for measuring the concentration of analytes in liquid samples such as bodily samples. The device comprises an application zone, to which a sample can be applied, and which contains a specific molecule capable of specifically binding the analyte of interest, said specific molecule being conjugated to a reporter which can give rise to variations in impedance. The resulting complex migrates by capillarity and enters a detection zone, on which another molecule capable of specifically binding the analyte of interest is immobilised. The concentration of reporter molecules in the detection zone is proportional with the concentration of analyte in the sample, and variations in concentration of reporter molecules yield a measurable change in electrical properties such as a change in impedance and/or capacitance which can be correlated to the concentration of analyte.
    Type: Application
    Filed: April 25, 2014
    Publication date: December 8, 2016
    Inventors: Jesper Fleischer, Michael Hasenkam, Nils E. Magnusson, Hans Nygaard
  • Publication number: 20160356771
    Abstract: A method of screening a sample of body fluid obtained from an animal subject for analyte autoantibodies reactive with one or more antigenic molecules selected from pancreatic islet cell antigenic molecules (GAD, 1A2) and insulin, or one or more variants, analogues, derivatives or fragments thereof, and a kit for use in such a method. After addition of the sample one or more complexes comprising [antigenic molecule of first source]-[analyte auto antibody]-[antigenic molecule of second source]. The antigenic molecule of first source is immobilised to a solid phase, the second is labelled.
    Type: Application
    Filed: August 19, 2016
    Publication date: December 8, 2016
    Inventors: Bernard Rees SMITH, Jadwiga FURMANIAK, Michael POWELL
  • Publication number: 20160356772
    Abstract: A method of screening a sample of body fluid obtained from an animal subject for analyte autoantibodies reactive with one or more antigenic molecules selected from pancreatic islet cell antigenic molecules (GAD, 1A2) and insulin, or one or more variants, analogues, derivatives or fragments thereof, and a kit for use in such a method. After addition of the sample one or more complexes comprising [antigenic molecule of first source]-[analyte auto antibody]-[antigenic molecule of second source]. The antigenic molecule of first source is immobilised to a solid phase, the second is labeled.
    Type: Application
    Filed: August 19, 2016
    Publication date: December 8, 2016
    Inventors: Bernard Rees SMITH, Jadwiga FURMANIAK, Michael POWELL
  • Publication number: 20160356773
    Abstract: Provided herein are bitter taste receptor ligands, related agents, combinations, compositions, methods and systems for modulating release of a metabolic hormone in vitro and in vivo from cells of the GI tract of an individual.
    Type: Application
    Filed: January 29, 2016
    Publication date: December 8, 2016
    Inventors: WILLIAM A. GODDARD, III, MARK MENNA, STEPHEN PANDOL, RAVINDER ABROL
  • Publication number: 20160356774
    Abstract: Disclosed herein are methods for the early, non-invasive diagnosis of antibody-mediated allograft rejection, methods of identifying a population of allograft recipients at risk for developing antibody-mediated rejection and methods of monitoring the treatment of patients for antibody-mediated rejection.
    Type: Application
    Filed: March 5, 2015
    Publication date: December 8, 2016
    Inventor: Behzad Najafian
  • Publication number: 20160356775
    Abstract: A method for aiding in categorising or determining prognosis in a patient with cancer, for example breast cancer (or, for example, hepatocellular, bladder or gastric cancer) or in selecting a therapeutic strategy for a patient with cancer, for example breast cancer (or, for example, hepatocellular, bladder or gastric cancer), the method comprising the step of assessing the level of LMTK3 nucleic acid, protein or activity in a sample obtained from the patient and/or assessing the patient's genotype for LMTK3, optionally at position rs8108419 (in intron 2 of the LMTK3 gene) and/or position rs9989661 (in intron 15 of the LMTK3 gene). The method may further comprise the step of assessing the level of ER? nucleic acid, protein or activity in a sample obtained from the patient, particularly in the case of breast cancer.
    Type: Application
    Filed: May 10, 2016
    Publication date: December 8, 2016
    Inventors: Georgios GIAMAS, Justin STEBBING
  • Publication number: 20160356776
    Abstract: The present invention provides a molecular construct capable of fluorescent resonance energy transfer (FRET), comprising a linker peptide, and donor and acceptor fluorophore moieties, where the linker peptide is a substrate of a botulinum neurotoxin selected from the group consisting of synaptobrevin, syntaxin and SNAP-25, or a fragment thereof capable being cleaved by the botulinum neurotoxin, and separates the donor and acceptor fluorophores by a distance of not more than 10 nm, and where emission spectrum of the donor fluorophore moiety overlaps with the excitation spectrum of the acceptor fluorophore moiety; or where the emission spectra of the fluorophores are detectably different. Also provided are isolated nucleic acid expressing the construct, kits comprising said construct and cell lines comprising said nucleic acid. Further provided are methods of detecting a BoNT using the above described construct via FRET, and methods for detecting a BoNT using surface plasmon resonance imaging.
    Type: Application
    Filed: July 11, 2016
    Publication date: December 8, 2016
    Inventors: Edwin R. Chapman, Min Dong
  • Publication number: 20160356777
    Abstract: This invention relates to a method for gastric cancer diagnosis through the detection of glycan changes, and to a kit for gastric cancer diagnosis. More specifically, based on the fact that in gastric cancer patient-derived haptoglobin, there are changes in N-linked glycosylation of haptoglobin, which are detected through lectin and mass spectrometery, that is, an increase in fucosylation, increases or significant changes in specific glycan structures depending on the classification of antennary structures, or a remarkable decrease in a high mannose structure of the N-glycan as compared to normal persons, N-glycan structures identified using the changes in N-linked glycosylation of haptoglobin may be usefully used as a diagnosis marker in a method for gastric cancer diagnosis using lectin or mass spectrometry, and a kit for gastric cancer diagnosis.
    Type: Application
    Filed: October 22, 2014
    Publication date: December 8, 2016
    Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Jung Hoe KIM, Sung Hyeon LEE, Seung Yeol PARK, Jin Man KIM, Hyun Joo AN, Jae-Han KIM, Myung Jin OH
  • Publication number: 20160356778
    Abstract: A method of identifying a subject having cancer who is likely to be responsive to a treatment compound, comprising administering a treatment compound to a subject having cancer; obtaining a sample from the subject; determining the ratio of a first biomarker level to a second biomarker level in the sample from the subject, wherein at least one of the biomarkers is a CRBN-associated protein; and diagnosing the subject as being likely to be responsive to the treatment compound if the ratio of the biomarker levels in the sample of the subject changes as compared to a reference ratio of the biomarker levels.
    Type: Application
    Filed: June 1, 2016
    Publication date: December 8, 2016
    Inventors: Hidekatsu IHA, Emi IKEBE
  • Publication number: 20160356779
    Abstract: Methods for grading carcinomas are provided as well as kits therefor. A method is provided for grading a carcinoma, or suspected carcinoma, comprising obtaining a sample of the carcinoma or suspected carcinoma and contacting the sample with one or more reagents so as to identify LacNAc or Gal.beta.1,4GlcNAc expression on cell surfaces thereof, quantifying the identified LacNAc or Gal.beta.1,4GlcNAc expression, and comparing quantified LacNAc or Gal.beta.1,4GlcNAc expression to one or more predetermined control values, and assigning a grade to the suspected carcinoma based on the quantified LacNAc or Gal.beta.1,4GlcNAc expression being in excess of, or less than, the one or more predetermined control values. Also provided is a method for identifying a sample from a subject as a carcinoma sample. Also provided is a kit for grading carcinoma samples comprising a LacNAc-specific or Gal-1,4GlcNAc-specific glycosylation enzyme and a synthetically-labeled sugar molecule and written instructions for use thereof.
    Type: Application
    Filed: February 9, 2015
    Publication date: December 8, 2016
    Applicant: Albert Einstein College of Medicine, Inc.
    Inventors: Peng WU, Sara ROUHANIFARD, Tianqing ZHENG
  • Publication number: 20160356780
    Abstract: New methods and assays for multiplexed detection of analytes using phosphors that are uniform in morphology, size, and composition based on their unique optical lifetime signatures are described herein. The described assays and methods can be used for imaging or detection of multiple unique chemical or biological markers simultaneously in a single assay readout.
    Type: Application
    Filed: June 6, 2016
    Publication date: December 8, 2016
    Inventors: Howard Y. BELL, Joshua E. COLLINS, Paul L.A.M. CORSTJENS, Sukwan HANDALI, Hans J. TANKE
  • Publication number: 20160356781
    Abstract: Provided are a fluorescent particle and a method for manufacturing the same. The fluorescent particle may include a gold nanoparticle; a silica shell covering the gold nanoparticle; and lanthanide group complex particles dispersed in the silica shell. Each of the lanthanide group complex particles may include a lanthanide group ion; a ligand bonded to the lanthanide group ion and including phosphorus; and a ligand bonded to the lanthanide group ion and having a beta diketone functional group. The fluorescent particle is observable with the naked eye and may emit light when ultraviolet light is irradiated. The fluorescent particle may be used for detecting and analyzing biomaterial samples.
    Type: Application
    Filed: August 18, 2014
    Publication date: December 8, 2016
    Inventors: So yeon KIM, Nae Young HEO, Jeaan JUNG, Won Jung KIM, Byung Gap HWANG, Young Seop KIM, Myoung Hoon LEE
  • Publication number: 20160356782
    Abstract: The present disclosure is directed to fluorogenic schiff base-forming dyes capable of detecting analytes containing aldehyde and ketone groups. The dyes contain nucleophilic hydrazinyl appendages and are capable of binding and detecting analytes in situ.
    Type: Application
    Filed: June 8, 2016
    Publication date: December 8, 2016
    Inventors: Aimei CHEN, Kyle Gee, Hee Chol Kang
  • Publication number: 20160356783
    Abstract: A multi-dimensional chromatographic method for the separation of N-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged N-glycan. The glycan preparation is then separated by anion-exchange chromatography and at least one secondary chromatographic technique.
    Type: Application
    Filed: August 19, 2016
    Publication date: December 8, 2016
    Inventors: Ian Christopher Parsons, Ting Zheng, Nur Sibel Gunay, Carlos J. Bosques
  • Publication number: 20160356784
    Abstract: The present invention is related to a method for detecting a protein comprising: (1) providing a fusion protein, wherein the fusion protein comprises the protein which is fused with a secondary antibody detected protein tag, wherein the secondary antibody detected protein tag comprises at least one epitope selected from the Fc region of at least one primary antibody which is capable of being detected by a corresponding secondary antibody; (2) contacting the fusion protein with a secondary antibody which binds to the secondary antibody detected protein tag to form a protein/antibody complex; and (3) detecting the protein/antibody complex.
    Type: Application
    Filed: August 23, 2016
    Publication date: December 8, 2016
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: TIAN-LU CHENG, Steve ROFFLER, WEN-WEI LIN, I-JU CHEN
  • Publication number: 20160356785
    Abstract: The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to methods and kits for determining the human sperm quality.
    Type: Application
    Filed: September 4, 2014
    Publication date: December 8, 2016
    Inventors: Nicolas SERGEANT, Valérie MITCHELL, Fanny JUMEAU, Julien SIGALA
  • Publication number: 20160356786
    Abstract: Compositions and methods of tagging peptides and other molecules using novel isobaric tandem mass tagging reagents, including novel N, N-dimethylated amino acid 8-plex and 16-plex isobaric tandem mass tagging reagents. The tagging reagents comprise: a) a reporter group having at least one atom that is optionally isotopically labeled; b) a balancing group, also having at least one atom that is optionally isotopically labeled, and c) an amine reactive group. The tagging reagents disclosed herein serve as attractive alternatives for isobaric tag for relative and absolute quantitation (iTRAQ) and tandem mass tags (TMTs) due to their synthetic simplicity, labeling efficiency and improved fragmentation efficiency.
    Type: Application
    Filed: June 14, 2016
    Publication date: December 8, 2016
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Lingjun LI, Feng XIANG, Tyler GREER, Dustin FROST, Zhidan LIANG
  • Publication number: 20160356787
    Abstract: Described herein are methods and compositions for the diagnosis, prognosis, selection of treatment and treatment of cancer, and particularly, of lung cancer such as non-small cell lung cancer. Embodiments of the present invention involve the detection of LKB1 levels and sensitivity to endoplasmic reticulum (ER) stress. Treatment can be made through the administration of ER stress activators.
    Type: Application
    Filed: February 18, 2015
    Publication date: December 8, 2016
    Applicant: Dignity Health
    Inventor: Landon J. Inge
  • Publication number: 20160356788
    Abstract: The invention provides methods of diagnosing and treating multiple sclerosis (MS) patients, including methods of identifying and treating multiple sclerosis patients who are at increased risk of developing a secondary autoimmune disease following lymphocyte depletion, caused, e.g., by treatment with an anti-CD52 antibody. Also embraced are methods of selecting treatment regimens for MS patients, and reagents useful in the above methods.
    Type: Application
    Filed: February 2, 2016
    Publication date: December 8, 2016
    Inventors: Alasdair J. Coles, Joanne L. Jones, Alastair Compston
  • Publication number: 20160356789
    Abstract: The present disclosure provides methods for assessing a subject's cardiovascular health. In one embodiment, the method comprises determining a level of cardiac Troponin I and a level of cardiac Troponin T in a sample, and comparing a combined score determined as a function of the cardiac Troponin levels to reference cardiac Troponin levels associated with a reference population. In some embodiments, the present disclosure provides methods of treating a subject, the method comprising determining a level of cardiac Troponin I and a level of cardiac Troponin T in a sample, comparing a combined score determined as a function of the cardiac Troponin levels to reference cardiac Troponin levels associated with a reference population, and initiating a therapeutic regimen in the subject if the combined score is greater than the reference cardiac Troponin levels.
    Type: Application
    Filed: April 6, 2016
    Publication date: December 8, 2016
    Inventors: Rebecca E. Caffrey, Joseph P. McConnell, Mohmed E. Ashmaig
  • Publication number: 20160356790
    Abstract: The present invention provides methods for measuring the total and/or activation levels of one or more analytes such as HER1, HER2, HER3, cMET, IGF-1R, PI3K, AKT, PRAS40, MEK, RSK, JAK1, STAT1, STAT3, TNF?, and/or anti-TNF? drug to determine whether a subject with inflammatory bowel disease (IBD) has non-inflamed and/or non-involved or inflamed and/or involved gastrointestinal tissue. The methods of the present invention can be used to evaluate mucosal healing, to diagnose, prognose, and monitor the progression of IBD, and to select and monitor the therapeutic response to IBD therapy.
    Type: Application
    Filed: June 2, 2016
    Publication date: December 8, 2016
    Applicant: NESTEC S.A.
    Inventors: SHARAT SINGH, KATHERINE DRAKE, ANJALI JAIN, RICHARD KIRKLAND, XINJUN LIU
  • Publication number: 20160356791
    Abstract: The present invention provides LMNA gene products as biomarkers for the determination of the vulnerability of an individual to an adverse health outcome when the individual is submitted to a stressor. As herewith provided, a decreased expression of a lamin A/C polypeptide, an increased expression in a lamin precursor polypeptide or a decreased ratio between the lamin A/C polypeptide/lamin precursor polypeptide is observed in individuals who are more vulnerable to an adverse health outcome upon the introduction of a stressor. In some embodiments, these susceptible individuals are considered as frail. The present application provides methods for using this biomarker to assess the risk associated thereto, commercial packages for performing the methods, software products as well as associated systems.
    Type: Application
    Filed: June 6, 2016
    Publication date: December 8, 2016
    Inventors: Jonathan Afilalo, Samuel Meyer Ohayon, Marc Afilalo
  • Publication number: 20160356792
    Abstract: Materials and methods related to diagnosing depression disorders, using a multi-parameter biomarker system and algorithms related thereto.
    Type: Application
    Filed: August 16, 2016
    Publication date: December 8, 2016
    Applicant: VINDRAUGA HOLDINGS, LLC
    Inventors: John Bilello, Bo Pi, Linda Thurmond
  • Publication number: 20160356793
    Abstract: The invention provides reagents and methods for diagnosing kidney disease in a human or animal.
    Type: Application
    Filed: August 22, 2016
    Publication date: December 8, 2016
    Inventors: Wallace B. Haigh, Donald L. Very, JR.
  • Publication number: 20160356794
    Abstract: The present invention provides novel antibodies that bind to human Tau and assays for quantifying human Tau using these antibodies.
    Type: Application
    Filed: February 9, 2015
    Publication date: December 8, 2016
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Omar Laterza, Michael Tanen, Oitak Wong
  • Publication number: 20160356795
    Abstract: A reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein, an in vitro method for the detection of a vitamin D compound in which the vitamin D compound is released from vitamin D-binding protein by the use of this reagent composition and the reagent mixture obtained in this manner. The use of the disclosed reagent composition to release vitamin D compounds as well as a kit for detecting a vitamin D compound which contains the reagent composition for releasing vitamin D compounds in addition to common detecting reagents.
    Type: Application
    Filed: August 22, 2016
    Publication date: December 8, 2016
    Inventors: Sascha Antoni, Christian Vogl
  • Publication number: 20160356796
    Abstract: An Fe(II) ion detection agent, and related method, capable of fluorescently detecting Fe(II) ions quickly with high sensitivity is disclosed. The Fe(II) ion detection agent can be a compound represented by formula (I) (fluorescence probe): wherein R1 and R2 represent lower alkyl; R3 and R4 represent hydrogen; R5 represents hydrogen, hydroxyl, or a group represented by formula (A): —NR51R52 wherein R51 and R52 represent lower alkyl; R6 and R7 represent hydrogen; ring A represents an aromatic ring; V represents O or SiR10R11 wherein R10 and R11 are the same or different and represent, hydrogen or lower alkyl; W represents CH2, CO; Z represents O; m and n are the same or different and represent 0 or 1. The agent can be combined with a compound having at least three coordinating positions.
    Type: Application
    Filed: January 16, 2015
    Publication date: December 8, 2016
    Applicant: Metallogenics Co., Ltd.
    Inventors: Hideko NAGASAWA, Tasuku HIRAYAMA
  • Publication number: 20160356797
    Abstract: A detector arrangement is disclosed for a blood culture bottle incorporating a colorimetric sensor which is subject to change of color due to change in pH or CO2 of a sample medium within the blood culture bottle. The detector arrangement includes a sensor LED illuminating the colorimetric sensor, a reference LED illuminating the colorimetric sensor, a control circuit for selectively and alternately activating the sensor LED and the reference LED, and a photodetector. The photodetector measures reflectance from the colorimetric sensor during the selective and alternating illumination of the colorimetric sensor with the sensor LED and the reference LED and generates intensity signals. The reference LED is selected to have a peak wavelength of illumination such that the intensity signals of the photodetector from illumination by the reference LED are not substantially affected by changes in the color of the colorimetric sensor.
    Type: Application
    Filed: August 18, 2016
    Publication date: December 8, 2016
    Inventor: Bradford G. Clay
  • Publication number: 20160356798
    Abstract: Biomarkers relating to de novo lipogenesis are provided, as well as methods for using such biomarkers in an Index to assess DNL. In addition, methods for diagnosing, determining predisposition to, and monitoring progression/regression of diseases related to DNL are provided. Also provided are methods of monitoring the efficacy of treatments for diseases related to DNL as well as other methods based on biomarkers of DNL.
    Type: Application
    Filed: December 18, 2014
    Publication date: December 8, 2016
    Inventor: Steven M. WATKINS
  • Publication number: 20160356799
    Abstract: The present invention telates to a method for detecting small molecular analytes in a sample, which method comprises derivatizing at least one small molecular analyte or at least one carrier molecule, in such way that one can bind to the other, thus forming at least one analyte-carrier complex, adding a detection immunoligand that s binds to the analyte-carrier complex, and detecting the small molecular analyte.
    Type: Application
    Filed: June 23, 2014
    Publication date: December 8, 2016
    Applicant: IMMUSMOL SAS
    Inventor: Alban Bessede
  • Publication number: 20160356800
    Abstract: The present invention relates to systems and methods of determining quality compliance for a set of biological sample testing devices used with one or more test instruments at the point-of-care in a hospital or other location that delivers medical care. In particular, the systems and methods ensure that only biological sample testing devices that pass a quality assurance protocol are used for point-of-care testing.
    Type: Application
    Filed: May 4, 2016
    Publication date: December 8, 2016
    Inventors: Paul Glavina, Jody Ann Tirinato