Patents Issued in January 26, 2017
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Publication number: 20170022556Abstract: Methods for determining the sequence of a polynucleotide comprising the steps of (i) contacting a polynucleotide processive enzyme immobilised in a fixed position, with a target polynucleotide under conditions sufficient to induce enzyme activity; (ii) detecting an effect consequent on the interaction of the enzyme and the polynucleotide, wherein the effect is detected by measurement of a non-linear optical signal or a linear signal coupled to a non-linear signal.Type: ApplicationFiled: September 29, 2016Publication date: January 26, 2017Inventor: Daniel Henry DENSHAM
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Publication number: 20170022557Abstract: The invention relates to a new method of determining the presence, absence or one or more characteristics of multiple analytes. The invention concerns coupling a first analyte to a membrane containing a detector and investigating the first analyte using the detector. The invention also concerns coupling a second analyte to the membrane and investigating the second analyte. The first analyte is uncoupled from the membrane prior to investigating the second analyte. The invention also relates to polynucleotide sequencing.Type: ApplicationFiled: March 31, 2015Publication date: January 26, 2017Applicant: Oxford Nanopore Technologies Ltd.Inventors: James Anthony Clarke, Marion Louise Crawford, James White
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Publication number: 20170022558Abstract: An integrated end-to-end system for large-scale, high-quality nucleic acid sequencing having a nucleic acid extraction module, a library preparation module, a nucleic acid sequencing module, and a data analysis module reversibly integrated with one another and having components that are physically loosely-coupled within such system and reversibly integrated for sequence interrogation and analysis. This system is fully automated from sample to data output. A workflow management system is integrated across all system components and provides an intuitive user interface for managing system operations.Type: ApplicationFiled: June 2, 2016Publication date: January 26, 2017Inventors: William Banyai, Scott Lockard, Daniel Chernikoff, David Rosenfeld, Arnold Oliphant
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Publication number: 20170022559Abstract: The present disclosure provides methods and systems for detecting multiple different nucleotides in a sample. In particular, the disclosure provides for detection of multiple different nucleotides in a sample utilizing fewer detection moieties than the number of nucleotides being detected and/or fewer imaging events than the number of nucleotides being detected.Type: ApplicationFiled: July 12, 2016Publication date: January 26, 2017Applicant: Illumina, Inc.Inventors: Robert C. Kain, Xiaohai Liu, Wenyi Feng, Bernard Hirschbein, Helmy A. Eltoukhy, Xiaolin Wu, Geoffrey Paul Smith, Jonathan Mark Boutell, Thomas Joseph, Randall Smith, Min-Jui Richard Shen, Carolyn Tregidgo, Kay Klausing
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Publication number: 20170022560Abstract: Efficient methods are disclosed for the high throughput identification of mutations in genes in members of mutagenized populations. The methods comprise DNA isolation, pooling, amplification, creation of libraries, high throughput sequencing of libraries, preferably by sequencing-by-synthesis technologies, identification of mutations and identification of the member of the population carrying the mutation and identification of the mutation.Type: ApplicationFiled: October 7, 2016Publication date: January 26, 2017Applicant: Keygene N.V.Inventors: Michael Josephus Theresia Van EIJK, Adrianus Johannes Van TUNEN
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Publication number: 20170022561Abstract: A method of predicting the risk of a patient for developing phenytoin-induced adverse drug reactions (ADRs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), or drug reactions with eosinophilia and systemic symptoms (DRESS) is disclosed. Genetic polymorphisms of CYP2C genes (including rs1057910 (CYP2C9*3) and rs3758581 on CYP2C19), and HLA alleles (including HLA-B*1502, HLA-B*1301, and HLA-B*5101) can predict adverse reactions caused by phenytoin or fosphenytoin. Accordingly, the present invention provides a kit to assess the risk of a patient for developing adverse reactions in response to phenytoin-related drugs, which comprises the determination of the presence of a specific allele selected from the group consisting of rs1057910 (CYP2C9*3), rs3758581 on CYP2C19, HLA-B*1502, HLA-B*1301, and HLA-B*5101, wherein the presence of at least one allele is indicative of a risk for the adverse drug reactions.Type: ApplicationFiled: October 5, 2016Publication date: January 26, 2017Inventors: WEN-HUNG CHUNG, SHUEN-IU HUNG
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Publication number: 20170022562Abstract: The present invention relates to markers and therapeutic targets of abnormal retinal pigment epithelium (RPE).Type: ApplicationFiled: January 23, 2015Publication date: January 26, 2017Inventor: Nady GOLESTANEH
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Publication number: 20170022563Abstract: The present invention provides compositions and methods based on genetic polymorphisms that are associated with coronary heart disease (particularly myocardial infarction), aneurysm/dissection, and/or response to drug treatment, particularly statin treatment. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.Type: ApplicationFiled: May 10, 2016Publication date: January 26, 2017Inventors: Olga IAKOUBOVA, James J. DEVLIN, Carmen TONG, Charles ROWLAND
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Publication number: 20170022564Abstract: The present invention is based on the discovery of genetic polymorphisms that are associated with psoriasis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, including groups of nucleic acid molecules that may be used as a signature marker set, such as a haplotype, a diplotype, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.Type: ApplicationFiled: May 11, 2016Publication date: January 26, 2017Inventors: Ann BEGOVICH, Ellen BEASLEY, Michele CARGILL, Steven SCHRODI
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Publication number: 20170022565Abstract: The disclosure provides a pair of isolated biomarkers selected from the group consisting of IBP4/SHBG, IBP4/PSG3, IBP4/LYAM1, IBP4/IGF2, CLUS/IBP3, CLUS/IGF2, CLUS/LYAM1, INHBC/PSG3, INHBC/IGF2, PSG2/LYAM1, PSG2/IGF2, PSG2/LYAM1, PEDF/PSG3, PEDF/SHBG, PEDF/LYAM1, CD14/LYAM1, and APOC3/LYAM1, wherein the pair of biomarkers exhibits a change in reversal value between pregnant females at risk for pre-term birth and term controls. Also provided is a method of determining probability for preterm birth in a pregnant female, the method comprising measuring in a biological sample obtained from the pregnant female a reversal value for at least one pair of biomarkers selected from the group consisting of IBP4/SHBG, IBP4/PSG3, IBP4/LYAM1, IBP4/IGF2, CLUS/IBP3, CLUS/IGF2, CLUS/LYAM1, INHBC/PSG3, INHBC/IGF2, PSG2/LYAM1, PSG2/IGF2, PSG2/LYAM1, PEDF/PSG3, PEDF/SHBG, PEDF/LYAM1, CD14/LYAM1, and APOC3/LYAM1 to determine the probability for preterm birth in the pregnant female.Type: ApplicationFiled: June 17, 2016Publication date: January 26, 2017Inventors: John Jay BONIFACE, Andrew GASSMAN, Jeff FLICK, Chad BRADFORD, Ashoka POLPITIYA, Tracey Cristine FLEISCHER, Durlin Edward HICKOK, Paul KEARNEY
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Publication number: 20170022566Abstract: The present invention provides novel mutations of the CFTR gene related to cystic fibrosis or to conditions associated with cystic fibrosis. The mutations include duplication of exons including duplication of exons 6b through 10. Methods of identifying if an individual contains the exons 6b through 10 duplication are provided as well as nucleic acid fragments that contain the junction site of the duplicated segment. The detection of additional mutations in the CFTR gene are also provided.Type: ApplicationFiled: July 28, 2016Publication date: January 26, 2017Applicant: Quest Diagnostics Investments IncorporatedInventor: Feras Hantash
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Publication number: 20170022567Abstract: The invention relates to polypeptides containing a cytoplasmic domain ending with a MAST-2 binding domain, from 11 to 13 residues, the first two residues of which are S and W, and the last four residues of which are Q, T, R and L, the polypeptides presenting a high affinity for the PDZ domain of the human MAST2 protein. The invention also relates to polynucleotides, vectors, lentiviral particles, cells as well as compositions containing the same. The invention is also directed to the use of the polypeptides, polynucleotides, vectors, lentiviral particles, cells and compositions in the treatment and/or prevention of a disease, disorder or condition, which alters the Central Nervous System (CNS) and/or the Peripheral Nervous System (PNS). The invention also concerns molecular signatures of cellular genes to determine the neurosurvival and/or neuroprotection activity of a molecule.Type: ApplicationFiled: September 14, 2016Publication date: January 26, 2017Inventors: Christophe Prehaud, Monique Lafon, Nicolas Wolff, Zakir Khan, Elouan Terrien, Sandrine Vitry
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Publication number: 20170022568Abstract: Sepsis remains a leading cause of morbidity and mortality in neonates worldwide. There is also clinically a low threshold for suspicion of infection in neonates, in particular as presentation varies greatly from very subtle to catastrophic collapse. The lack of reliably sensitive tests and the potential life-threatening consequences of delayed treatment of infection results in the widespread use of empirical antibiotics exposing many infants without infection to broad-spectrum antibiotics. The present invention provides a series of patient-invariant biomarkers for screening neonates and other subjects for infection that predicts bacterial infection with high accuracy; and is further shown to have predictive value in identifying infection in suspected cases with blood-culture negative tests.Type: ApplicationFiled: April 7, 2015Publication date: January 26, 2017Inventors: Peter GHAZAL, Paul DICKINSON, Thorsten FORSTER, Claire SMITH, Ben STENSON, Mizan KHONDOKER
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Publication number: 20170022569Abstract: This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.Type: ApplicationFiled: June 24, 2016Publication date: January 26, 2017Inventors: Victor Abkevich, Alexander Gutin, Kirsten Timms, Jerry Lanchbury
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Publication number: 20170022570Abstract: The current disclosure provides, inter alia, method of determining benign nodules from thyroid cancer in a subject that is found to have a thyroid nodule, method of treating thyroid cancer in a subject detected to have thyroid cancer by the method of the current disclosure, compositions for determining benign nodules from thyroid cancer in a subject, and kits including reagents and composition for determining benign nodules from thyroid cancer in a subject.Type: ApplicationFiled: July 22, 2016Publication date: January 26, 2017Inventors: MARIA A. HAHN, John H. Yim, Yuman Fong, Arthur X. Li, Xiwei Wu
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Publication number: 20170022571Abstract: The current invention pertains to miRNAs that are differentially expressed in samples of an individual having pancreatic cancer, or having a high risk of developing pancreatic cancer, as compared to the corresponding sample of an individual not having pancreatic cancer, or having low risk of developing pancreatic cancer, respectively. In certain embodiments, the miRNAs are differentially expressed in a tissue sample or blood plasma sample of an individual having a pancreatic lesion and having a high risk of developing pancreatic cancer as compared to the corresponding tissue sample or blood sample of an individual having the pancreatic lesion and having no risk or low risk of developing pancreatic cancer. These differentially expressed miRNAs can be used as biomarkers for diagnosis, treatment, and/or prevention of pancreatic cancer, particularly, in a subject having a pancreatic lesion.Type: ApplicationFiled: March 31, 2015Publication date: January 26, 2017Inventors: MOKENGE P. MALAFA, JENNIFER PERMUTH-WEY, DUNG-TSA CHEN
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Publication number: 20170022572Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions related to certain mutations in cancer. In one embodiment, a method for treating a subject having aggressive thyroid cancer comprises the steps of (a) obtaining a biological sample from the subject; (b) performing an assay on the sample obtained from the subject to identify a mutation at 1 295 228 C>T (C228T), corresponding to ?124 C>T from the translation start site in the promoter of the telomerase reverse transcriptase (TERT) gene, and a T1799A mutation in the BRAF gene that results in a V600E amino acid change; (c) identifying the subject as having or likely to develop aggressive thyroid cancer if the C228T and V600E mutations are identified; and (d) treating the subject with one or more treatment modalities appropriate for a subject having or likely to develop aggressive thyroid cancer.Type: ApplicationFiled: April 1, 2015Publication date: January 26, 2017Inventor: Michael Xing
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Publication number: 20170022573Abstract: The present invention provides compositions and methods for the multiplex detection of biomarkers in an environmental, non-biological or biological sample. Compositions and methods are provided for simultaneously detecting and identifying multiple pathogens, including viruses, bacteria, fungi, protozoa and helminths, present in a sample.Type: ApplicationFiled: April 10, 2015Publication date: January 26, 2017Inventors: Erle S. ROBERTSON, James ALWINE
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Publication number: 20170022574Abstract: The present invention is the field of plant breeding. More specifically, the invention focuses on the use of molecular markers to select for a genetic locus contributing to haploid induction.Type: ApplicationFiled: August 22, 2016Publication date: January 26, 2017Inventors: Rahul Dhawan, Jennifer L. Jacobs, Warren M. Kruger, Bryce M. Lemke, Ryan A. Rapp, Minghui Sun, Christopher A. Taylor
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Publication number: 20170022575Abstract: Various methods and compositions are provided for identifying and/or selecting soybean plants or soybean germplasm with tolerance or improved tolerance to Phytophthora infection. In certain embodiments, the method comprises detecting at least one marker locus that is associated with tolerance to Phytophthora infection. In other embodiments, the method further comprises detecting at least one marker profile or haplotype associated with tolerance to Phytophthora infection. In further embodiments, the method comprises crossing a selected soybean plant with a second soybean plant. Further provided are markers, primers, probes and kits useful for identifying and/or selecting soybean plants or soybean germplasm with tolerance or improved tolerance to Phytophthora infection.Type: ApplicationFiled: October 7, 2016Publication date: January 26, 2017Inventors: JULIAN M CHAKY, Holly J. Jessen, Joshua M. Shendelman, Paul A. Stephens, David M. Webb, John B. Woodward, Meizhu Yang
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Publication number: 20170022576Abstract: In alternative embodiments, provided are products of manufacture, such as assays, chimeric nucleic acids and nucleic acid constructs, recombinant cells, and methods, comprising use of beta3-integrin (ITGB3) promoters operatively linked to a reporter, for drug screening, and in particular, screening for agents that inhibit cancer cell survival and metastasis. In alternative embodiments, compositions and methods as provided herein also can be used to identifying novel pathways that lead to acquired resistance, stemness, and anchorage independent growth; and characterizing distinct populations of cancer cells within a tumor microenvironment.Type: ApplicationFiled: March 18, 2016Publication date: January 26, 2017Inventors: David CHERESH, Maricel GOZO, Mayra YEBRA, Laetitia SEGUIN
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Publication number: 20170022577Abstract: A first intracellular pathogen in a biological sample that may contain more than one intracellular pathogen is studied by a method comprising the steps of (i) contacting the sample with a population of cells in the presence of an agent inhibiting the reproduction of a second intracellular pathogen; (ii) incubating the cells under conditions that permit the reproduction of the first intracellular pathogen; and (iii) testing material arising from step (ii) for the first intracellular pathogen.Type: ApplicationFiled: September 23, 2016Publication date: January 26, 2017Applicant: Novartis AGInventor: Theodore TSAI
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Publication number: 20170022578Abstract: In an apparatus, comprising a plant for the electrothermic preparation of ethyne from coal or a hydrocarbon-containing gas providing a hydrogen-containing gas, a plant for the production of iron by reduction of oxidic iron ores, and at least one gas conduit which feeds the hydrogen-containing gas from the plant for the electrothermic preparation of ethyne as reducing agent to the plant for the production of iron by reduction of oxidic iron ores, electric energy can be utilized for the production of iron from oxidic iron ores by feeding a hydrogen-containing gas, obtained in the electrothermic preparation of ethyne from coal or a hydrocarbon-containing gas, as reducing agent to the plant for the production of iron by reduction of oxidic iron ores.Type: ApplicationFiled: March 20, 2015Publication date: January 26, 2017Applicant: EVONIK DEGUSSA GMBHInventors: GEORG MARKOWZ, RAOUL NEUHAUS, FLORIAN BÖSS, HARALD SCHNEIDER, MARTIN MÖLLER
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Publication number: 20170022579Abstract: A cooling device configured to cool an article to be treated by immersing the article to be treated in coolant includes a cooling chamber configured to accommodate the article to be treated and store the coolant therein, a supply nozzle configured to supply the coolant into the cooling chamber from below the article to be treated, a recovery pipeline configured to collect the coolant stored in the cooling chamber from above the article to be treated, and a pump configured to pump the coolant collected by the recovery pipeline to the supply nozzle.Type: ApplicationFiled: October 4, 2016Publication date: January 26, 2017Applicants: IHI Corporation, IHI Machinery and Furnace Co., Ltd.Inventors: Kazuhiko KATSUMATA, Kaoru ISOMOTO, Takahiro NAGATA, Akira NAKAYAMA, Yuusuke SHIMIZU, Gen NISHITANI
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Publication number: 20170022580Abstract: Provided is a spring steel that contains 0.15-0.40% carbon, 1-3.5% silicon, 0.20-2.0% manganese, 0.05-1.20% chromium, at most 0.030% phosphorus, at most 0.02% sulfur, and at least one of the following: 0.005-0.10% titanium, 0.005-0.05% niobium, and at most 0.25% vanadium. The remainder of said spring steel comprises iron and unavoidable impurities. The carbon equivalent (Ceq1) of the provided spring steel, as calculated by formula (1), is at most 0.55. Ceq1=[C]+0.108×[Si]?0.067×[Mn]+0.024×[Cr]?0.05×[Ni]+0.074×[V]??(1) (In the formula (1), each symbol in brackets represents the content (mass %) of the corresponding element.Type: ApplicationFiled: October 5, 2016Publication date: January 26, 2017Applicant: KABUSHIKI KAISHA KOBE SEIKO SHO (KOBE STEEL, LTD.)Inventors: Sayaka NAGAMATSU, Tomotada MARUO, Nao YOSHIHARA
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Publication number: 20170022581Abstract: A seamless steel tube has a particular composition and a structure with an average prior ? grain size of 150 ?m or less in an axial cross-section after cold drawing and heat treatment. The structure retards the growth of a fatigue crack. The steel tube has a tensile strength TS of 500 MPa or more and good internal pressure fatigue resistance and is suitable for use as a fuel injection tube under high injection pressures. The composition of the steel tube may further contain at least one of Cu, Ni, Cr, Mo, and B; at least one of Ti, Nb, and V; and/or Ca.Type: ApplicationFiled: March 20, 2015Publication date: January 26, 2017Inventors: Yoshikazu Kawabata, Manabu Nishino, Makio Gunji
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Publication number: 20170022582Abstract: A high-strength cold-rolled steel sheet having good ductility, hole expandability, and delayed fracture resistance and being excellent in material homogeneity. The steel sheet has a chemical composition containing, in mass %, C: 0.15 to 0.25%, Si: 1.2 to 2.2%, Mn: 1.7 to 2.5%, P: 0.05% or less, S: 0.005% or less, Al: 0.01 to 0.10%, N: 0.006% or less, Ti: 0.003 to 0.030%, B: 0.0002 to 0.0050%, and Fe and inevitable impurities. The steel sheet has a microstructure that includes ferrite having an average crystal grain diameter of 4 ?m or less at a volume fraction of 5 to 20%, retained austenite at a volume fraction of 5% or less, including 0%, and tempered martensite at a volume fraction of 80 to 95%. Additionally, the mean free path of the ferrite is 3.0 to 7.5 ?m.Type: ApplicationFiled: March 17, 2015Publication date: January 26, 2017Applicant: JFE STEEL CORPORATIONInventors: Katsutoshi TAKASHIMA, Kohei HASEGAWA
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Publication number: 20170022583Abstract: A steel material for highly deformable line pipes that has superior strain aging resistance, superior HIC resistance, and a metallographic structure including ferrite, bainite, and martensite-austenite constituent. The area fraction of the martensite-austenite constituent is 0.5 to 5.0%, and the difference in hardness between the ferrite and the bainite is 60 or more in terms of Vickers hardness. Additionally, the steel material has a uniform elongation of 9% or more and a yield ratio of 90% or less both before a strain aging treatment at a temperature of 300° C. or lower and after the strain aging treatment.Type: ApplicationFiled: March 26, 2015Publication date: January 26, 2017Applicant: JFE STEEL CORPORATIONInventors: Kyono YASUDA, Daisuke MIZUNO, Haruo NAKAMICHI, Nobuyuki ISHIKAWA
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Publication number: 20170022584Abstract: A method of laser hardening a surface area of a workpiece, such as a surface of a journal of a crankshaft, includes the step of: generating a relative movement between the surface of the workpiece and a laser source to allow a laser spot to subsequently be projected onto different portions of said surface area. The method also includes the step of repetitively scanning the laser beam so as to produce a two-dimensional equivalent effective laser spot on said surface area, during the relative movement. The scanning pattern can include at least three substantially parallel lines which the laser spot follows in a certain order. When the workpiece includes several journals having different widths, two laser sources may be used to harden the surface area of the wider journals.Type: ApplicationFiled: February 11, 2015Publication date: January 26, 2017Inventors: Jesús DOMÍNGUEZ, Paula SANCHO, Olatz BILBAO
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Publication number: 20170022585Abstract: Disclosed herein is a method for recovering an acid or a base during a metal extraction process. The method comprises contacting a feed stream comprising the acid or base and the metal with an ultrafiltration membrane to produce an ultrafiltration retentate and an ultrafiltration permeate, and contacting the ultrafiltration permeate with a nanofiltration membrane. The nanofiltration retentate produced comprises a majority of the metal from the feed stream, and the nanofiltration permeate produced comprises a majority of the acid or base from the feed stream. Also disclosed herein is a recovery apparatus for recovering an acid or a base during a metal extraction process.Type: ApplicationFiled: April 22, 2014Publication date: January 26, 2017Inventors: Paul BOSHOFF, Merrill FORD, Shana MCDOUGALL, Mark PEACOCK
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Publication number: 20170022586Abstract: A nickel-base alloy of, in atomic percent unless otherwise stated, up to 8 percent Fe, up to 16 percent Co, between 15 and 25 percent Cr, up to 3 percent Mo, up to 2 percent W, between 3 and 5 percent Al, between 3 and 7.5 percent Nb, up to 3 percent Ta, up to 0.2 percent Ti, up to 0.5 percent C, up to 0.175 percent B, up to 0.07 percent Zr, up to 1 percent Mn, up to 1 percent Si, up to 0.2 percent Hf, the balance of Ni and incidental impurities, wherein the atomic ratio of Al to Nb is between 0.4 and 1.7, the atomic ratio of the sum of Al and Ti to Nb is between 0.4 and 1.8, and, the composition including at least 10 percent of elements from the group of Al, Nb, and Ti.Type: ApplicationFiled: June 23, 2016Publication date: January 26, 2017Applicant: ROLLS-ROYCE plcInventors: Mark C. HARDY, Howard J. STONE, Nicholas G. JONES, Paul M. MIGNANELLI
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Publication number: 20170022587Abstract: A nanocomposite comprising metal and carbon-based nanotube (CNT), wherein the carbon-based nanotube comprises a doping element selected from the group consisting of boron (B), iron (Fe), zinc (Zn), nickel (Ni), cadmium (Cd), tin (Sn), antimony (Sb), Nitrogen (N) and the combination thereof, and methods of making the nanocomposite.Type: ApplicationFiled: April 9, 2015Publication date: January 26, 2017Inventor: Kofi W. Adu
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Publication number: 20170022588Abstract: A centrifugally cast composite metal product having an axis of rotational symmetry and a mass of at least 5 kg, comprises a host metal and insoluble solid refractory particles of & refractory material in a non-uniform distribution throughout the host metal. The particles have a density that is within 30% of the density of the host metal at its casting temperature.Type: ApplicationFiled: December 30, 2014Publication date: January 26, 2017Inventors: Xinhu Tang, Kevin Francis Dolman
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Publication number: 20170022589Abstract: An acetone storage tank or acetone transfer pipe comprising stainless steel in which the amount of Cr is in the range 10.5 wt % to 20 wt %; the amount of Ni is ?9 wt %, and the amount of Mo is 2.75%?Mo?0 wt %, of the stainless steel.Type: ApplicationFiled: October 5, 2016Publication date: January 26, 2017Inventors: René Dicke, Andreas Leitner
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Publication number: 20170022590Abstract: A steel material for highly deformable line pipes that has superior strain aging resistance, superior HIC resistance, and a metallographic structure composed mainly of ferrite and bainite. The total area fraction of the ferrite and the bainite is 90% or more, and the difference in hardness between the ferrite and the bainite is 70 or more in terms of Vickers hardness. Additionally, the steel material has a uniform elongation of 9% or more and a yield ratio of 90% or less both before a strain aging treatment at a temperature of 300° C. or lower and after the strain aging treatment.Type: ApplicationFiled: March 26, 2015Publication date: January 26, 2017Applicant: JFE STEEL CORPORATIONInventors: Kyono YASUDA, Daisuke MIZUNO, Haruo NAKAMICHI, Nobuyuki ISHIKAWA
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Publication number: 20170022591Abstract: An aluminum alloy composition includes, in weight percent: less than or equal to 0.70 iron; less than or equal to 0.30 silicon; and less than or equal to 0.30 copper, with the balance being aluminum and other elements, with the other elements being present at up to 0.05 weight percent each and up to 0.15 weight percent total. The alloy is homogenized at a temperature of 520° C. to 570° C. for 2-10 hours. The volume phase fraction of ?-AlFeSi phase present in the homogenized aluminum alloy product may be at least 10%.Type: ApplicationFiled: March 31, 2015Publication date: January 26, 2017Inventors: Xiao-Guang Chen, Mohammad Shakiba, Nicholas C. Parson
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Publication number: 20170022592Abstract: Provided herein are anodized quality AA6xxx series aluminum alloy sheets and methods for making anodized quality AA6xxx series aluminum alloy sheets. Also described herein are products prepared from the anodized quality AA6xxx series aluminum alloy sheets. Such products include consumer electronic products, consumer electronic product parts, architectural sheet products, architectural sheet product parts, and automobile body parts.Type: ApplicationFiled: July 18, 2016Publication date: January 26, 2017Applicant: Novelis Inc.Inventors: Alok Gupta, Daehoon Kang, Rajeev G. Kamat, Devesh Mathur
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Publication number: 20170022593Abstract: The invention is a class of new 6XXX series high strength aluminum alloys with a fine grain structure and methods of manufacture and extrusion. Aluminum alloys of the invention comprise from about 0.90 percent to about 1.2 percent by weight silicon, up to about 0.5 percent by weight iron, from about 0.05 percent to about 0.3 percent by weight copper, up to about 0.75 percent by weight manganese, from about 0.70 percent to about 1.0 percent by weight magnesium, up to about 0.25 percent by weight chromium, up to about 0.05 percent by weight zinc, up to about 0.1 percent by weight titanium, with the balance consisting essentially of aluminum. The alloys are cast and homogenized, then extruded, quenched and artificially aged to produce a fine grain crystallization in the final aluminum product exhibiting superior yield strength and elongation properties.Type: ApplicationFiled: March 11, 2015Publication date: January 26, 2017Inventor: David A. Lukasak
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Publication number: 20170022594Abstract: The invention relates to a method for the treatment of an alloy based on titanium aluminide. The method comprises the following steps, during which no hot isostatic pressing is carried out: obtaining a semi-finished product (7) produced by centrifugal casting, then heat treating the semi-finished product in order to obtain an alloy microstructure comprising gamma grains and/or lamella grains (alpha2/gamma).Type: ApplicationFiled: April 2, 2015Publication date: January 26, 2017Applicant: Safran Aircraft EnginesInventors: Guillaume Martin, Céline Jeanne Marcillaud, Marie Mineur-Panigeon
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Publication number: 20170022595Abstract: The present invention provides a plasma-resistant component for use in a plasma apparatus, wherein an oxide film is formed on at least part of a surface of a substrate of the component, the oxide film is a deposited oxide film formed as an aggregate of polycrystalline particles, the polycrystalline particles being formed by sinter-bonding of microparticles having an average particle size of 0.05 to 3 ?m, and the deposited oxide film has a film thickness of 10 ?m or more and 200 ?m or less and a film density of 90% or more. Due to above structure, it becomes possible to obtain a plasma-resistant component and a method of manufacturing a plasma-resistant component in which the generation of particles removed from the component is stably and effectively suppressed, and damage such as corrosion and deformation rarely occur during the regeneration process.Type: ApplicationFiled: March 20, 2015Publication date: January 26, 2017Applicants: KABUSHIKI KAISHA TOSHIBA, TOSHIBA MATERIALS CO., LTD.Inventors: Michio SATO, Takashi HINO, Masashi NAKATANI, Takashi NAKAMURA
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Publication number: 20170022596Abstract: A carburizing device includes a furnace body that performs heat treatment on a treatment object to perform carburization treatment on the treatment object, in which: a heater configured to perform heat treatment on the treatment object is provided upright in a vertical direction within the furnace body; a gas supply section configured to supply a gas for burnout toward the heater is provided at a lower end part of the heater; the heater is inserted through a protective tube provided upright in the vertical direction; and the gas supply section is configured to supply the gas for burnout to between the protective tube and the heater.Type: ApplicationFiled: October 7, 2016Publication date: January 26, 2017Applicants: IHI Corporation, IHI Machinery and Furnace Co., Ltd.Inventors: Kazuhiko KATSUMATA, Masatoshi MITSUZUKA, Osamu SAKAMOTO, Takahiro NAGATA
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Publication number: 20170022597Abstract: A machine for coating an optical article with an anti-soiling coating composition, includes a vacuum chamber (8) configured to receive the optical article, a vacuum pump (20) connected to the vacuum chamber (8), a plasma generator (11) configured to carry out a vacuum plasma treatment of the optical article, an evaporation device (10) configured to carry out a vacuum evaporation treatment of the composition for depositing it on the optical article, a control unit (2) controlling the plasma generator for removing an initial outermost anti-soiling coating of the article, controlling the evaporation device for recoating the article with the anti-soiling coating composition, being configured to causes the vacuum pump (20) to suck gases from the chamber (8) during vacuum plasma treatment and being further configured to causes the vacuum pump (20) not to suck gases from the chamber (8) during vacuum evaporation treatment.Type: ApplicationFiled: October 6, 2016Publication date: January 26, 2017Inventors: Reto STROBEL, Stephan SCHOLZE, Gérald FOURNAND, Narendra BORGHARKAR
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Publication number: 20170022598Abstract: A depositing arrangement for evaporation of a material including an alkali metal or alkaline earth metal, and for deposition of the material on a substrate is described. The depositing arrangement includes a first chamber configured for liquefying the material, wherein the first chamber comprises a gas inlet configured for inlet of a gas in the first chamber, an evaporation zone configured for vaporizing the liquefied material, a line providing a fluid communication between the first chamber and the evaporation zone for the liquefied material, wherein the line includes a first portion defining a flow resistance of the line, a valve configured for controlling the flow rate of the gas in the first chamber for controlling a flow rate of the liquefied material through the line having said flow resistance, and one or more outlets for directing the vaporized material towards the substrate.Type: ApplicationFiled: December 6, 2013Publication date: January 26, 2017Inventors: Uwe SCHÜßLER, Stefan BANGERT, Karl-Albert KEIM, Jose Manuel DIEGUEZ-CAMPO
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Publication number: 20170022599Abstract: Method for the decoration of small three-dimensional objects (1, 1a) comprising the steps of: providing a semi-finished three-dimensional object (2) to be treated comprising a support (10); by means of physical vapor deposition (PVD), realizing on at least one surface (5) of said support (10) a metallization layer (12) comprising a three-dimensional FIG. 15, 15a), said three-dimensional FIG. 15, 15a) comprising a plurality of reliefs and/or recesses (20, 21). A three-dimensional impression (16, 16a) is provided on at least one surface (5) of said support, comprising a plurality of projections and/or cavities (18, 19), for which the metallization layer realized by means of the PVD treatment presents a three-dimensional FIG. 15, 15a), comprising a plurality of reliefs and/or recesses (20, 21) respectively in correspondence of said projections and cavities (18, 19). The three-dimensional impression (16, 16a) is obtained by means of a laser marking treatment.Type: ApplicationFiled: July 19, 2016Publication date: January 26, 2017Inventor: Luciano PEREGO
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Publication number: 20170022600Abstract: An evaporator body for a PVD coating system comprises a basic body and an evaporator surface, to which a titanium dihydride layer is applied. A titanium hydride layer comprises an organic carrier agent and titanium hydride as the single inorganic solid. The thickness of the layer is less than or equal to 10 ?m.Type: ApplicationFiled: July 20, 2016Publication date: January 26, 2017Inventors: Rudolf Karl GRAU, Rodrigue NGOUMENI YAPPI, Hubert Josef SCHWEIGER
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Publication number: 20170022601Abstract: A processing apparatus for processing devices, particularly devices including organic materials therein, is described. The processing apparatus includes a processing vacuum chamber; at least one evaporation source for organic material, wherein the at least one evaporation source includes at least one evaporation crucible, wherein the at least one evaporation crucible is configured to evaporate the organic material, and at least one distribution pipe with one or more outlets, wherein the at least one distribution pipe is in fluid communication with the at least one evaporation crucible; and a maintenance vacuum chamber connected with the processing vacuum chamber, wherein the at least one evaporation source can be transferred from the processing vacuum chamber to the maintenance vacuum chamber and from the maintenance vacuum chamber to the processing vacuum chamber.Type: ApplicationFiled: August 19, 2014Publication date: January 26, 2017Inventors: Jose Manuel DIEGUEZ-CAMPO, Stefan BANGERT, Uwe SCHÜßLER, Dieter HAAS
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Publication number: 20170022602Abstract: There is provided an oxide sintered body including indium, tungsten and zinc, wherein the oxide sintered body includes a bixbite type crystal phase as a main component and has an apparent density of higher than 6.5 g/cm3 and equal to or lower than 7.1 g/cm3, a content rate of tungsten to a total of indium, tungsten and zinc is higher than 1.2 atomic % and lower than 30 atomic %, and a content rate of zinc to the total of indium, tungsten and zinc is higher than 1.2 atomic % and lower than 30 atomic %. There are also provided a sputtering target including this oxide sintered body, and a semiconductor device including an oxide semiconductor film formed by a sputtering method by using the sputtering target.Type: ApplicationFiled: March 18, 2015Publication date: January 26, 2017Applicant: SUMITOMO ELECTRIC INDUSTRIES, LTD.Inventors: Miki MIYANAGA, Kenichi WATATANI, Koichi SOGABE
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Publication number: 20170022603Abstract: Sputter targets and methods of making same. The targets comprise B doped n-type Si. The targets may be made from single crystal boron doped p-type Si ingot made by the CZ method. Resistivities along the length of the crystal are measured, and blanks may be cut perpendicular to the ingot central axis at locations having resistivities of from about 1-20 ohm.cm. The blanks are then formed to acceptable shapes suitable for usage as sputter targets in PVD systems. No donor killing annealing is performed on the ingot or blanks.Type: ApplicationFiled: March 18, 2015Publication date: January 26, 2017Inventors: Eugene Y. Ivanov, Yongwen Yuan
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Publication number: 20170022604Abstract: A system and method for single magnetron sputtering are described. One example includes a system having a power supply, a plasma chamber enclosing a substrate, an anode, and a target for depositing a thin film material on the substrate. This example also has a datastore with uncoated anode characterization data and an anode sputtering adjustment system including an anode analysis component to generate a first health value. The first health value is indicative of whether the anode is coated with a dielectric material. This example also has an anode power controller to receive the first health value and provide an anode-energy-control signal to the pulse controller of the pulsed DC power supply to adjust a second anode sputtering energy relative to a first anode sputtering energy to eject at least a portion of the dielectric material from the anode.Type: ApplicationFiled: July 24, 2015Publication date: January 26, 2017Inventors: David Christie, Skip B. Larson
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Publication number: 20170022605Abstract: A vapor deposition apparatus that performs co-deposition to deposit different vapor deposition materials onto a vapor deposition target. The vapor deposition apparatus includes: a chamber accommodating the vapor deposition target; a first vapor deposition source ejecting vapor of a first vapor deposition material towards the vapor deposition target; a second vapor deposition source ejecting vapor of a second vapor deposition material differing from the first vapor deposition material towards the vapor deposition target; a first heater heating the first vapor deposition material; a second heater heating the second vapor deposition material; and a heat controller controlling the first and second heaters. The heat controller is capable of controlling the first and second heaters so that increasing of the temperature of the second vapor deposition material is commenced after a predetermined time period has elapsed from commencement of increasing of the temperature of the first vapor deposition material.Type: ApplicationFiled: February 23, 2015Publication date: January 26, 2017Applicant: JOLED INC.Inventor: Akira TAKIGUCHI