Patents Issued in March 14, 2017
  • Method of and apparatus for controlling a gasifier
    Patent number: 9593283
    Abstract: A method of controlling a circulating fluidized bed gasifier includes feeding first and second portions of particulate material to be gasified through inlets in a gasifier. Oxygen and steam are fed through a bottom grid into a lower portion of the gasifier to fluidize the bed. Product gas and entrained particles are discharged from an upper portion of the gasifier. Particles are separated from the product gas and a portion of the separated particles is returned to the lower portion. A portion of the returned particles is oxidized to generate heat. Heat and oxidizing products from the lower portion are transferred to the center portion to generate the product gas. A ratio of the first and second portions of particulate material to be gasified is determined on the basis of a measured temperature profile so as to control the vertical temperature distribution in the gasifier.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: March 14, 2017
    Assignee: AMEC FOSTER WHEELER ENERGIA OY
    Inventors: Juha Palonen, Sami Kokki, Katja Häkkinen
  • Methods for the preparation and delivery of fuel compositions
    Patent number: 9593284
    Abstract: A process for generating a main fuel composition comprising methanol and water and not more than 20% by weight dimethyl ether, and a fumigant comprising dimethyl ether, the process comprising: providing a pre-fuel composition comprising methanol and dimethyl ether, adding water to the pre-fuel composition to cause or aid evaporation of at least a portion of the dimethyl ether from the pre-fuel composition, collecting the portion of dimethyl ether evaporated from the pre-fuel composition for use as a fumigant, and using the remainder of the pre-fuel composition comprising methanol and water as a main fuel composition. The water may be at a temperature above ambient.
    Type: Grant
    Filed: November 24, 2014
    Date of Patent: March 14, 2017
    Assignee: Gane Energy & Resources Pty Ltd
    Inventor: Greg Morris
  • Unleaded gasoline formulations including mesitylene and pseudocumene
    Patent number: 9593285
    Abstract: The present invention provides an unleaded, piston engine fuel formulation comprising a blend of mesitylene, pseudocumene and isopentane having a MON of at least 94 and an RVP of 38 to 49 kPa at 37.8° C. In certain aspects, the formulation comprises specific weight percentages of each of the mesitylene, pseudocumene and isopentane components, and varying MON ratings. In additional aspects, the formulations comprise a combination of mesitylene, isopentane, and one or more additional components selected from the group consisting of pseudocumene, toluene and xylenes. In certain embodiments, the formulations also include alkylates and or alkanes. The formulations have unusually high MON ratings, and desirable RVP and distillation curve characteristics for formulations not including additional components, particularly octane boosters.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: March 14, 2017
    Assignee: Swift Fuels, LLC
    Inventor: Chris D'Acosta
  • Method and system for cogenerating gas-steam based on gasification and methanation of biomass
    Patent number: 9593286
    Abstract: A method for cogenerating gas-steam based on gasification and methanation of biomass. The method includes: 1) mixing oxygen and water vapor with biomass, transporting the resulting mixture via a nozzle to a gasifier, gasifying the biomass to yield crude gasified gas, and transporting superheated steam having a pressure of 5-6 MPa resulting from sensible heat recovery to a steam turbine; 2) adjusting the hydrogen/carbon ratio of the crude gasified gas generated from step 1) to 3:1, and eluting the crude gasified gas whereby yield purified syngas; 3) introducing the purified syngas from step 2) to a methanation unit and transporting intermediate pressure superheated steam generated in the methanation unit to the steam turbine; and 4) concentrating methane of synthetic natural gas containing trace nitrogen and water vapor obtained from step 3) through pressure swing adsorption.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: March 14, 2017
    Assignee: SUNSHINE KAIDI NEW ENERGY GROUP CO., LTD.
    Inventors: Weiguang Yang, Yan Gong, Xiaodong Zhan, Dechen Song
  • Process for producing a lubricant from an epoxy-triglyceride
    Patent number: 9593287
    Abstract: A process for producing a lubricant from an epoxy-triglyceride comprising treating the epoxy-triglyceride with an esterifying agent in the presence of a heterogeneous catalyst under conditions to produce the lubricant is disclosed.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: March 14, 2017
    Assignee: University of Saskatchewan
    Inventors: Ajay Kumar Dalai, Rajesh Vishnudev Sharma
  • Lubricants from mixed alpha-olefin feeds
    Patent number: 9593288
    Abstract: This invention discloses an improved process which employs mixed alpha-olefins as feed over activated metallocene catalyst systems to provide essentially random liquid polymers particularly useful in lubricant components or as functional fluids.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: March 14, 2017
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Margaret M. Wu, Norman Yang, Phil Surana, Anura Patil, Steven P. Rucker, Kuangnan Qian, Shakeel Tirmizi, Mark P. Hagemeister
  • Corrosion inhibiting hydraulic fluid additive
    Patent number: 9593289
    Abstract: Corrosion inhibiting hydraulic fluid additives, kits, and methods are disclosed. The hydraulic fluid additive may be adapted for use with brake fluid in vehicular brake systems. The kits may include an additive, a hydraulic fluid tester, and/or correlated information on test results and hydraulic fluid service actions.
    Type: Grant
    Filed: February 24, 2015
    Date of Patent: March 14, 2017
    Inventor: Jon A. Petty
  • Lubricating oil composition and production thereof
    Patent number: 9593290
    Abstract: This invention relates to a lubricating oil composition and production thereof. The lubricating oil composition comprises a Mannich base represented by the following formula (III) (wherein A and R2 are as defined in the specification) and a lubricant base oil. The lubricating oil composition according to this invention exhibits excellent cleansing and dispersing performance and excellent anticorrosion performance.
    Type: Grant
    Filed: April 25, 2013
    Date of Patent: March 14, 2017
    Assignees: CHINA PETROLEUM & CHEMICAL CORPORATION, RESEARCH INSTITUTE OF PETROLEUM PROCESSING SINOPEC
    Inventors: Shihao Xin, Xin Xie, Zuoxin Huang, Qinghua Duan, Zhiqiang Wu, Lihua Wang
  • Lubricating oil composition, and sliding mechanism using lubricating oil composition
    Patent number: 9593291
    Abstract: Disclosed is a lubricating oil composition for low-friction sliding materials, which is used in a sliding mechanism where a DLC film containing hydrogen in an amount of from 5 atom % to 50 atom % is formed on at least one sliding surface. The lubricating oil composition contains, in the lubricant base oil therein and based on the total amount of the composition, (A) an organic zinc dithiophosphate in an amount of from 0.005% by mass to 0.12% by mass in terms of the phosphorus concentration therein, (B) an amide-based friction-reducing agent in an amount of from 0.05% by mass to 5.0% by mass, and (C) an alkaline earth metal salicylate-based detergent and/or an alkaline earth metal sulfonate-based detergent in an amount of from 0.05% by mass to 0.5% by mass in terms of the alkaline earth metal concentration therein.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: March 14, 2017
    Assignee: IDEMITSU KOSAN CO., LTD.
    Inventors: Yoko Ogahara, Moritsugu Kasai, Hiroaki Koshima, Masanori Tsujioka, Koji Miyake
  • Engine lubricants containing a polyether
    Patent number: 9593292
    Abstract: A lubricant comprising (a) an oil of lubricating viscosity; (b) a polyether of number average molecular weight 1000 to 10,000; said polyether comprising alkylene oxide monomer units, where the alkylene group contains 3 to 6 carbon atoms, and ethylene oxide monomer units; and (c) one or more anti-foam agents, where the lubricant has a sulfated ash content of less than about 0.7 percent, is useful for lubricating a stationary gas engine where the engine drives a compressor and where both the engine and the compressor are lubricated with the same lubricant.
    Type: Grant
    Filed: February 17, 2014
    Date of Patent: March 14, 2017
    Assignee: The Lubrizol Corporation
    Inventors: Virginia A. Carrick, Alvin E. Haas, Jonathan S. Vilardo
  • Lubricating composition
    Patent number: 9593293
    Abstract: A lubricating formulation prepared from a blend of components comprised of 35-55% of a first base oil; 30-50% of a second base oil; 0.5-5% of a hydrophobic fumed silica; and 1-10% of a hydrophilic fumed silica, wherein the hydrophobic fumed silica and the hydrophilic fumed silica are introduced during formulation so that the hydrophobic famed silica and the hydrophilic fumed silica are pulverized, discharged and dissolved under a surface the blend during formulation.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: March 14, 2017
    Inventor: Sal A. Randisi, Sr.
  • Sensory use of 6-cyclopentylidenehexane derivatives
    Patent number: 9593294
    Abstract: The invention concerns the use of 6-cyclopentylidenehexane derivatives—6, cyclopentylidenehexan-1-ol and 6-cyclopentylidenehexanal—as sensory agents giving off a fragrance and/or a flavor of interest for a use in perfumery, in cosmetic, in parapharmacy, in detergent industry and in the food industry.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: March 14, 2017
    Assignee: V. MANE FILS
    Inventors: Agnes Muratore, Jean-Jacques Chanot
  • Surfactants with lower CMC, and surfactant systems and detergents containing said surfactants
    Patent number: 9593295
    Abstract: The invention relates to surfactants of the formula (I), in which R1 stands for —H or —CH3; R2, R3, R4, R5, R6 independently stand for —H, —CH3, —CH2CH3, —CH2CH2CH3, —CH(CH3)2, —CH2CH2CH2CH3, —CH2CH(CH3)2, —CH(CH3)CH2CH3, —C(CH3)3, —OH, —OCH3, —OCH2CH3, —OCH2CH2CH3, —OCH(CH3)2, a linear or branched alkyl group containing 8 to 20 C atoms, or —SO3?X+; X+ stands for a monovalent cation or the nth part of an n-valent cation; exactly one radical R2, R3, R4, R5, R6 stands for —SO3?X+; and exactly one radical R2, R3, R4, R5, R6 stands for a linear or branched alkyl radical containing 8 to 20 C atoms.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: March 14, 2017
    Assignees: Henkel AG & Co. KGaA & Studiengesellschaft, Kohle mbH
    Inventors: Christian Kropf, Nicole Bode, Danuta Bedrunka, Roberto Rinaldi, Hebert Jesus Estevez Rivera
  • Laundry detergent compositions including fermented fruit solutions
    Patent number: 9593296
    Abstract: Described herein are laundry detergent compositions comprising fermented fruit solutions and natural based surfactants, methods for making the same, and methods for using the same. The fermented fruit solutions can contain fruit, sugar and water. The natural based surfactant can be selected from the group consisting of sodium lauryl sulfate, cocamidopropyl betaine, alkyl polyglycoside, and mixtures thereof. The laundry detergent compositions can be used to clean articles, launder articles, and clean stains from articles.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: March 14, 2017
    Assignee: EQUATOR GLOBAL LIMITED
    Inventors: Peter Nelson Wainman, Sirilak Narongtanupone, Sungworn Sangsri
  • Compositions for removing residues and related methods
    Patent number: 9593297
    Abstract: Compositions for removing residues from a semiconductor structure. The compositions comprise water, a base, a polydentate chelator, a degasser, and a fluorine source. The compositions comprise greater than or equal to approximately 99 wt % of the water and are formulated to exhibit a pH of from approximately 10.0 to approximately 12.0. Methods of forming and using the compositions are also disclosed.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: March 14, 2017
    Assignee: MICRON TECHNOLOGY, INC.
    Inventors: Cole S. Franklin, Jerome A. Imonigie
  • Composition comprising fatty acyl isethionate and synthetic wax and method producing the same
    Patent number: 9593298
    Abstract: A method of preparing a component of a personal care bar, the method comprising: (a) providing a composition comprising an isethionate surfactant at a temperature of at least 20° C.; (b) combining the composition comprising the isethionate surfactant with a synthetic 5 wax and optional further components at a temperature of at least 120° C.; and (c) cooling the mixture obtained in step (b).
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: March 14, 2017
    Assignee: Innospec Limited
    Inventors: Phillip Loraine Cotrell, Philip Arie Matena, Stephen Moss O'Connor
  • Treatment compositions containing water-soluble polyelectrolyte complex which are self-limiting
    Patent number: 9593299
    Abstract: The present invention relates to aqueous compositions of associative polyelectrolyte complexes (PECs), optionally containing surfactants, biocidal agents and/or oxidants, which can provide a cleaning benefit and surface protection to treated articles including reduced soiling tendency, reduced cleaning effort and improved soil repellancy, as well as providing bacteriostatic properties to treated surfaces that thereby gain resistance to water, environmental exposure and microbial challenge.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: March 14, 2017
    Assignee: The Clorox Company
    Inventors: David R. Scheuing, William L. Smith, Michael Kinsinger, Jared Heymann
  • Device for fuel and chemical production from biomass-sequestered carbon dioxide and method therefor
    Patent number: 9593300
    Abstract: A process and apparatus for sequestering carbon and converting it to fuel, such as methane, and/or materials, such as fermentation substrates, biopolymers, bioplastics, oils, pigments, biochar, metals, such as mercury, chromium and arsenic, fibers, proteins, vitamins, fertilizers and animal feed. The apparatus comprises a deep well carbon-sequestering bioreactor coaxially located within a deep well anaerobic bioreactor. Carbon is sequestered into a photosynthetic biomass or a heterotrophic biomass, which is subsequently digested by an anaerobic biomass containing methanogenic microbes, whereby methane is a digestion product. Alternatively, the biomass can be subjected to physical-chemical treatment to produce oil and other useful byproducts.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: March 14, 2017
    Inventors: Prasad S Kodukula, Charles R Stack
  • Method and system for harvesting micro organisms
    Patent number: 9593302
    Abstract: In an embodiment of the invention, aqueous growth medium in a pond can be used to grow algae which can be pumped to a primary dewatering device where the algae can be separated from the harvested growth media based on the flow of the harvested growth media and gravity. The flow through the primary de-watering device can be optimized to maintain log phase growth in the pond, while minimizing the pumping cost and maximizing the concentration of total solids in the primary de-watered algae.
    Type: Grant
    Filed: December 15, 2014
    Date of Patent: March 14, 2017
    Assignee: INDEPENDENCE BIO-PRODUCTS, INC.
    Inventors: Christopher J Davies, John Russell Teague, Ronald A Erd
  • Method for continuously culturing and
    Patent number: 9593303
    Abstract: The present invention relates to a method of culturing bacterial organisms belonging to the family Anaplasmataceae in mammalian embryonic or fetal cells. In particular, the present invention is directed to growth of bacterial organisms belonging to the family Anaplasmataceae including organisms belonging to the Anaplasma, Ehrlichia and Neorickettsia genera. The bacterial organisms may be cultured in mammalian embryonic or fetal host cells including feline embryonic host cells. Bacterial material cultured according to the methods described herein may be used as the basis for vaccines against diseases associated with the Anaplasmataceae bacteria, or as the basis for diagnostic applications useful for diagnosing diseases associated with the Anaplasmataceae bacteria.
    Type: Grant
    Filed: May 7, 2015
    Date of Patent: March 14, 2017
    Assignee: Intervet Inc.
    Inventors: Jane Kwun-Lai Battles, Kimberly D. Proudfoot, Brenda L. Meding, Patrick G. Funk, R. Monty Warthen, F. Randall Bethke, Eric A. Ellis, Amy Y. Purse
  • Three-dimensional discontinuous entity for cell culturing
    Patent number: 9593304
    Abstract: The present invention is related to methods and materials for culturing and transporting stem cells in a three-dimensional culture. The materials comprise cellulose nanofibrils in a form of three-dimensional discontinuous entities in a biocompatible hydrogel.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: March 14, 2017
    Assignee: UPM-KYMMENE CORPORATION
    Inventors: Antti Laukkanen, Yan-Ru Lou, Marjo Yliperttula, Tytti Kuisma, Johanna Nikander, Jaakko Pere
  • Differentiation of pluripotent stem cells
    Patent number: 9593305
    Abstract: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: March 14, 2017
    Assignee: Janssen Biotech, Inc.
    Inventors: Janet Davis, Jiajian Liu, Christine Parmenter, Pascal Ghislain André Bonnet
  • Differentiation of pluripotent stem cells
    Patent number: 9593306
    Abstract: The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: March 14, 2017
    Assignee: Janssen Biotech, Inc.
    Inventors: Janet Davis, Jiajian Liu, Christine Parmenter, Pascal Ghislain André Bonnet
  • Defined media for expansion and maintenance of pluripotent stem cells
    Patent number: 9593307
    Abstract: The present invention provides methods to promote the proliferation of undifferentiated pluripotent stem cells in defined media. Specifically, the invention provides a defined cell culture formulation for the culture, maintenance, and expansion of pluripotent stem cells, wherein culturing stem cells in the defined cell culture formulation maintains the pluripotency and karyotypic stability of the cells for at least 10 passages. Further disclosed is a cell population, grown under defined media conditions, that expresses OCT4, SOX2, NANOG, and FOXA2.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: March 14, 2017
    Assignee: Janssen Biotech, Inc.
    Inventor: Alireza Rezania
  • Device for enhancing immunostimulatory capabilities of T-cells
    Patent number: 9593308
    Abstract: T-cells are generated with enhanced immunostimulatory capabilities for use in self therapy treatment protocols, by utilizing a biodegradable device with a biodegradable support that has one or more agents that are reactive to T-cell surface moieties. The biodegradable devices are mixed with the T-cells sufficiently so that the one or more agents cross-link with the T-cells' surface moieties and deliver a signal to the T-cells to enhance immunostimulatory capabilities.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: March 14, 2017
    Assignee: IMMUNOVATIVE THERAPIES LTD.
    Inventor: Michael Har-Noy
  • Media for culturing, preserving, and administering regenerative cells
    Patent number: 9593309
    Abstract: A culture media, media supplement, or soluble matrix for cryopreservation or enhanced regenerative cell growth in culture and maintenance of multi-lineage differentiation potentiation. The inventive culture media, media supplement, or soluble matrix comprises a GAG composition comprising a sulfated GAG, such as chondroitin sulfate. A soluble matrix, a cell administration package or kit comprising the soluble matrix and a device for cell administration, and a method of use thereof, for administration of regenerative cells for treating a joint disease or other weakened or damaged tissue comprising the specified GAG compositions are further provided.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: March 14, 2017
    Assignees: ArthroDynamic Holdings, LLC, InGeneron Incorporated
    Inventors: Michael Coleman, Ivone Bruno, Rudy Martinez, Amir Sanchez, Eckhard Alt, Frank D. Marcum, Paul Shealy
  • Differentiation of human embryonic stem cells
    Patent number: 9593310
    Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells expressing markers characteristic of the pancreatic endocrine lineage that co-express NKX6.1 and insulin and minimal amounts of glucagon.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: March 14, 2017
    Assignee: Janssen Biotech, Inc.
    Inventor: Jean Xu
  • Wnt pathway stimulation in reprogramming somatic cells with nuclear reprogramming factors
    Patent number: 9593311
    Abstract: The invention provides compositions and methods of use in reprogramming somatic cells. Compositions and methods of the invention are of use, e.g., for generating or modulating (e.g., enhancing) generation of induced pluripotent stem cells by reprogramming somatic cells. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a pluripotent state and/or enhances the speed and/or efficiency of reprogramming. Certain of the compositions and methods relate to modulating the Wnt pathway.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: March 14, 2017
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Brett Chevalier, Alexander Marson, Richard A. Young, Ruth Foreman, Rudolf Jaenisch
  • Viral vector construct for neuron specific optimized continuous DOPA synthesis in vivo
    Patent number: 9593312
    Abstract: The present invention relates to a one-vector expression system comprising a sequence encoding two polypeptides, such as tyrosine hydroxylase (TH) and GTP-cyclohydrolase 1 (GCH1). The two polypeptides can be should preferentially be expressed at a ratio between 3:1 and 15:1, such as between 3:1 and 7:1. The invention is useful in the treatment of catecholamine deficient disorders, such as dopamine deficient disorders including but not limited to Parkinson's Disease. Moreover, the present invention provides a method to deliver the vector construct in order to limit the increased production of the catecholamine to the cells in need thereof.
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: March 14, 2017
    Assignee: Genepod Therapeutics AB
    Inventors: Tomas Björklund, Anders Björklund, Deniz Kirik
  • 28 kDa GST proteins from schistosoma for the use thereof in the treatment of inflammatory autoimmune diseases generating a Th1 and/or Th17 response
    Patent number: 9593313
    Abstract: The present invention relates to a product selected from a protein, a fragment of the protein, a derived sequence and a homologous sequence of the protein, the protein including or being constituted by the 28 kDa glutathione S-transferase protein from a schistosome selected from Schistosoma haematobium, Schistosoma mansoni, Schistosoma bovis represented respectively by the sequences SEQ ID NO: 1, SEQ ID NO: 2 and SEQ ID NO: 3 for the use thereof in the treatment of an inflammatory autoimmune disease generating a response of type Th1 and/or Th17.
    Type: Grant
    Filed: February 6, 2013
    Date of Patent: March 14, 2017
    Assignees: UNIVERSITE DU DROIT ET DE LA SANTE DE LILLE 2, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE
    Inventors: Monique Capron, Mohamed El Nady, Jean-Frederic Colombel, Gilles Riveau
  • Binding molecules with antitumoral activity
    Patent number: 9593314
    Abstract: The present invention relates to a binding molecule that specifically binds to two different epitopes of an antigen expressed on tumor cells, wherein the binding molecule comprises: (a) a first binding (poly)peptide that specifically binds to a first epitope of said antigen expressed on tumor cells, wherein said first binding (poly)peptide is a Fyn SH3-derived polypeptide; and (b) a second binding (poly)peptide that specifically binds to a second epitope of said antigen expressed on tumor cells. The present invention further relates to a nucleic acid molecule encoding the binding molecule of the invention, a vector comprising said nucleic acid molecule as well as a host cell or a non-human host transformed with said vector. The invention further relates to a method of producing a binding molecule of the invention as well as to pharmaceutical and diagnostic composition.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: March 14, 2017
    Assignee: Covagen AG
    Inventors: Simon Brack, Frédéric Mourlane, Isabella Toller, Richard Woods, Julian Bertschinger, Dragan Grabulovski, Babette Schade, Kristina Klupsch, Helen Hachemi
  • Mutant RB69 DNA polymerase
    Patent number: 9593315
    Abstract: Provided herein are mutant DNA-dependent polymerases which are derived from, or otherwise related to, wild type RB69 DNA polymerase. These mutant polymerases are capable of selectively binding labeled nucleotides. These mutant polymerases are also capable of incorporating a variety of naturally occurring and modified nucleotides, including, for example, terminator nucleotides.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: March 14, 2017
    Assignee: Life Technologies Corporation
    Inventors: Marian Peris, Michael Phelan, Barnett Rosenblum, Stephen Hendricks
  • Polynucleotides encoding mutant hydrolase proteins with enhanced kinetics and functional expression
    Patent number: 9593316
    Abstract: The invention provides a mutant hydrolase protein with enhanced kinetics and functional expression, as well as polynucleotides encoding the mutant proteins and methods of using the polynucleotides and mutant proteins.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: March 14, 2017
    Assignee: Promega Corporation
    Inventors: Aldis Darzins, Lance P. Encell, Rachel Friedman Ohana, Paul Otto, Michael R. Slater, Gediminas Vidugiris, Keith V. Wood, Monika G. Wood, Kate Qin Zhao, Kris Zimmerman
  • Methods and means to modify a plant genome at a nucleotide sequence commonly used in plant genome engineering
    Patent number: 9593317
    Abstract: Methods and means are provided to modify in a targeted manner the plant genome of transgenic plants comprising chimeric genes wherein the chimeric genes have a DNA element commonly used in plant molecular biology. Re-designed meganucleases to cleave such an element commonly used in plant molecular biology are provided.
    Type: Grant
    Filed: June 7, 2011
    Date of Patent: March 14, 2017
    Assignee: Bayer CropScience NV
    Inventor: Kathleen D'Halluin
  • Linker-bridged gene or domain fusion reverse transcriptase enzyme
    Patent number: 9593318
    Abstract: The present invention relates to combinations of a linker bridged gene or domain fusion reverse transcriptase enzyme, and more particularly, combinations of a linker bridged gene or domain fusion reverse transcriptase enzyme and their fusion construction utilizing for more efficient and quality DNA synthesis in reverse transcription. The composition of the invention includes a polymerase domain; a linker, consisting of 3-40 amino acids; and an RNase H domain, wherein the RNase H domain is either unmodified or modified with point mutations. The composition may further include another mutated RNase H, a mutated RNase A, and an additional linker which consists of 3-40 amino acids.
    Type: Grant
    Filed: April 25, 2013
    Date of Patent: March 14, 2017
    Inventor: Jun Euihum Lee
  • Temperature-stable ?-pyranosidase
    Patent number: 9593319
    Abstract: The invention relates to temperature-stable polypeptides with ?-pyranosidase activity. The polypeptide substrates include ?-glucopyranosides and ?-xylopyranosides. The polypeptides can be expressed alone or as fusion proteins for example in yeast or bacteria and subsequently purified. The polypeptides according to the invention can be used alone or in a mixture with other enzymes for the degradation of plant raw materials, among others for the enzymatic degradation of biomass containing lignocellulose, in particular hemicellulose and the hemicellulose component xylan. The enzymes are suitable for use in textile processing, as an additive of detergents, or in the food or feed industry.
    Type: Grant
    Filed: October 26, 2011
    Date of Patent: March 14, 2017
    Assignee: CLARIANT PRODUKTE (DEUTSCHLAND) GMBH
    Inventors: Christoph Reisinger, Farah Qoura, Barbara Klippel, Garabed Antranikian
  • Proteases with modified pro regions
    Patent number: 9593320
    Abstract: The present invention provides methods and compositions for the production of mature proteases in bacterial host cells. The compositions include modified polynucleotides that encode modified proteases, which have at least one mutation in the pro region; the modified serine proteases encoded by the modified polynucleotides; expression cassettes, DNA constructs, and vectors comprising the modified polynucleotides that encode the modified proteases; and the bacterial host cells transformed with the vectors of the invention. The methods include methods for enhancing the production of mature proteases in bacterial host cells e.g. Bacillus sp. host cells. The produced proteases find use in the industrial production of enzymes, suitable for use in various industries, including but not limited to the cleaning, animal feed and textile processing industry.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: March 14, 2017
    Assignee: DANISCO US INC.
    Inventors: Eugenio Ferrari, Carol Fioresi, Anita van Kimmenade
  • L-arabinose isomerase variants with improved conversion activity and method for production of D-tagatose using them
    Patent number: 9593321
    Abstract: The present invention relates to the development of an L-arabinose isomerase variant from Thermotoga neapolitana DSM 5068, which is a kind of thermophile, on the basis of protein molecular modeling. Moreover, the present invention relates to a method of producing D-tagatose from D-galactose by using the enzyme or a microorganism of the genus Corynebacterium expressing the enzyme.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: March 14, 2017
    Assignee: CJ Cheiljedang Corporation
    Inventors: In Seok Oh, Chang Gyeom Kim, Seung Hyun Cho, Seong Bo Kim, Yang Hee Kim, Kyong Yeon Cho, Sung Jae Yang, Jin Ha Kim
  • Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases
    Patent number: 9593322
    Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: March 14, 2017
    Assignees: aTyr Pharma, Inc., Pangu BioPharma Limited
    Inventors: Leslie Ann Greene, Kyle P. Chiang, Fei Hong, Alain P. Vasserot, Wing-Sze Lo, Jeffry D. Watkins, Cheryl L. Quinn, John D. Mendlein
  • Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases
    Patent number: 9593323
    Abstract: Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: March 14, 2017
    Assignees: aTyr Pharma, Inc., Pangu BioPharma Limited
    Inventors: Leslie Ann Greene, Kyle P. Chiang, Fei Hong, Alain P. Vasserot, Wing-Sze Lo, Jeffry D. Watkins, Cheryl L. Quinn, John D. Mendlein
  • Treatment of cellulosic material and enzymes useful therein
    Patent number: 9593324
    Abstract: The present invention relates to the production of sugar hydrolysates from cellulosic material. The method may be used e.g. for producing fermentable sugars for the production of bioethanol from lignocellulosic material. Cellulolytic enzymes and their production by recombinant technology is described, as well as uses of the enzymes and enzyme preparations.
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: March 14, 2017
    Assignee: Roal Oy
    Inventors: Jari Vehmaanperä, Marika Alapuranen, Terhi Puranen, Matti Siika-Aho, Jarno Kallio, Satu Jamsa, Sanni Voutilainen, Teemu Halonen, Liisa Viikari
  • Stable lysis buffer mixture for extracting nucleic acids
    Patent number: 9593325
    Abstract: Embodiments relate to a lysis buffer mixture that is stable in storage for isolating nucleic acids from biological, preferably diagnostic samples. The mixture is preferably associated with an extraction control. The aim of the invention is to provide an improved nucleic acid extraction system, which is cost-effective, stable and easy to use, thus fulfilling the requirements of a modern nucleic acid extraction system and containing, among other things, extraction controls. Embodiments relate to a lysis buffer mixture for isolating nucleic acids, said mixture containing non chaotropic salts, a special selection of detergents, a defined quantity of at least one nucleic acid as an extraction control, optionally lytic enzymes, optionally carrier nucleic acids and optionally other additives.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: March 14, 2017
    Assignee: STRATEC BIOMEDICAL AG
    Inventors: Peter Bendzko, Hans Joos
  • Protein variant generation by region shuffling
    Patent number: 9593326
    Abstract: Region shuffling methods for efficiently introducing diversity and exploring sequence space are described. Libraries produced directly from these methods contain high fractions of protein variants harboring multiple beneficial mutations. Typically, the methods produce these variants efficiently without the need for sequencing beneficial mutants identified at intermediate stages of the process.
    Type: Grant
    Filed: June 25, 2012
    Date of Patent: March 14, 2017
    Assignee: Codexis, Inc.
    Inventors: Louis Clark, Trish Choudhary
  • Identification of antigen or ligand-specific binding proteins
    Patent number: 9593327
    Abstract: The present invention discloses novel methods for the generation, expression and screening of diverse collections of binding proteins such as antibodies or fragments thereof in vertebrate host cells in vitro, for the identification and isolation of ligand- or antigen-specific binding proteins. The methods disclosed herein allow the expression of diverse collections of binding proteins from at least one vector construct, which optionally can give rise to collections of diverse binding proteins upon transfer and expression into vertebrate host cells in situ.
    Type: Grant
    Filed: April 15, 2014
    Date of Patent: March 14, 2017
    Assignee: AGENUS INC.
    Inventors: Ulf Grawunder, Jorn Stitz
  • Method of nucleic acid amplification
    Patent number: 9593328
    Abstract: A nucleic acid molecule can be annealed to an appropriate immobilized primer. The primer can then be extended and the molecule and the primer can be separated from one another. The extended primer can then be annealed to another immobilized primer and the other primer can be extended. Both extended primers can then be separated from one another and can be used to provide further extended primers. The process can be repeated to provide amplified, immobilized nucleic acid molecules. These can be used for many different purposes, including sequencing, screening, diagnosis, in situ nucleic acid synthesis, monitoring gene expression, nucleic acid fingerprinting, etc.
    Type: Grant
    Filed: January 20, 2015
    Date of Patent: March 14, 2017
    Assignee: Illumina, Inc.
    Inventors: Eric H. Kawashima, Laurent Farinelli, Pascal Mayer
  • Assembly of large nucleic acids
    Patent number: 9593329
    Abstract: A method to assemble any desired nucleic acid molecule by combining cassettes in vitro to form assemblies which are further combined in vivo, or by assembling large numbers of DNA fragments by recombination in a yeast culture to obtain desired DNA molecules of substantial size is described.
    Type: Grant
    Filed: October 7, 2008
    Date of Patent: March 14, 2017
    Assignee: Synthetic Genomics, Inc.
    Inventors: Daniel G. Gibson, Lei Young, John I. Glass, Gwynedd A. Benders, J. Craig Venter, Clyde A. Hutchison, III, Hamilton O. Smith
  • Treatment of frataxin (FXN) related diseases by inhibition of natural antisense transcript to FXN
    Patent number: 9593330
    Abstract: The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Frataxin (FXN), in particular, by targeting natural antisense polynucleotides of Frataxin (FXN). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of FXN.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: March 14, 2017
    Assignee: CuRNA, Inc.
    Inventors: Joseph Collard, Olga Khorkova Sherman
  • Double-stranded nucleic acid molecule for gene expression control
    Patent number: 9593331
    Abstract: Provided are an improved double-stranded nucleic acid molecule involved in gene expression control mediated by a gene silencing mechanism, a method of producing the molecule, and a pharmaceutical composition comprising the double-stranded nucleic acid molecule. The double-stranded nucleic acid molecule for gene expression control comprises an antisense strand having a length of 18 to 28 nucleotides and a sense strand including a complementary moiety composed of a sequence sufficiently complementary to the antisense strand and a protruding single-stranded 5?-end moiety having a length of 2 to 100 nucleotides. The sense strand and the antisense strand form base pairs via the complementary moiety. The method produces such a double-stranded nucleic acid molecule, and the pharmaceutical composition contains such a double-stranded nucleic acid molecule as an active ingredient.
    Type: Grant
    Filed: November 1, 2012
    Date of Patent: March 14, 2017
    Assignee: Osaka City University
    Inventors: Akira Tachibana, Toshizumi Tanabe
  • Methods and compositions for targeting immunoglobulins
    Patent number: 9593332
    Abstract: The present invention relates to compositions and methods for targeting immunoglobulins and immunoglobulin-producing plasma cells. In particular, the present invention provides nucleic acid based compounds for targeting immunoglobulins for research, screening, and therapeutic applications.
    Type: Grant
    Filed: January 15, 2014
    Date of Patent: March 14, 2017
    Assignee: TUFTS MEDICAL CENTER
    Inventors: Raymond Comenzo, Ping Zhou, Xun Ma
  • Modulation of apolipoprotein C-III (ApoCIII) expression in lipoprotein lipase deficient (LPLD) populations
    Patent number: 9593333
    Abstract: Provided are methods, compounds, and compositions for reducing expression of ApoCIII mRNA and protein for treating, preventing, delaying, or ameliorating Fredrickson Type I dyslipidemia/FCS/LPLD, in a patient. Such methods, compounds, and compositions increase HDL levels and/or improving the ratio of TG to HDL and reducing plasma lipids and plasma glucose in the patient, and are useful to treat, prevent, delay, or ameliorate any one or more of pancreatitis, cardiovascular disease, metabolic disorder, and associated symptoms.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: March 14, 2017
    Assignee: Ionis Pharmaceuticals, Inc.
    Inventors: Veronica J. Alexander, Nicholas J. Viney, Joseph L. Witztum