Abstract: A regional anaesthesia injection apparatus comprising an injection volume determiner. The apparatus configured to determine a volume of a regional anaesthetic injection into a target tissue; an injection pressure determiner configured to determine a pressure of the injection; and a controller coupled to the injection volume determiner and to the injection pressure determiner and configured to provide an injection signal to control injection of fluid into the target tissue based on the determined pressure and the determined volume.

Abstract: A novel aromatherapy vaporization device is disclosed having a heating chamber first portion for receiving of phyto material and a heating chamber second portion. In a first mode of operation phyto material is loaded into the heating chamber first portion having a first conductive heating element disposed therein and in a second mode of operation an angle of a hinge is varied that brings the heating chamber second portion in proximity to the heating chamber first portion. In the second mode of operation electrical current flows from a first battery to a first conductive heating element and the phyto material is heated to a predetermined temperature and vapor is emitted from the heating of the phyto material and is captured in the heating chamber second portion and flows through a heating chamber first portion aperture and propagates through a fluid pathway for inhalation from an inhalation aperture.

Abstract: A large lumen guide catheter (10) has an elongate tubular body (22), which has an outer surface (24), an inner surface (44), and a braided wire layer between the inner surface and the outer surface, wherein the wires winding a first helical direction are thicker and wider than the wire winding in a second helical direction opposite the first helical direction.

Abstract: In some examples, a catheter may include a catheter body configured such that at least one of a proximal portion or a medial portion of the catheter body has a cross-sectional shape including at least three apexes, adjacent apexes being connected by curvilinear sidewalls, the cross-section being taken substantially orthogonal to a longitudinal axis of the catheter body. In some examples, the entire catheter body has the cross-sectional shape including at least three apexes, adjacent apexes being connected by curvilinear sidewalls. In other examples, only a portion of the catheter body has the cross-sectional shape.

Abstract: This disclosure concerns polymer catheter designs incorporating joints that break under tension. The joints are generally formed from two tubular elements comprising two different polymers with dissimilar thermal and/or mechanical characteristics, which are overlapped and exposed to heat and pressure. The disclosure also concerns methods of making and using such catheters, for instance to deliver medical implants.

Abstract: An injection catheter includes a drive mechanism, an elongate, flexible tubular body, and a first inner member. The tubular body has a distal end portion, a proximal end portion, and defines a first lumen extending therebetween. The first inner member includes a proximal end coupled to the drive mechanism and is rotatably disposed within the first lumen. The first inner member and the first lumen define an annular gap therebetween configured to deliver a therapeutic agent contained therein from the proximal end portion to the distal end portion of the tubular body when the first inner member is rotated within the lumen such that shear stresses exerted on the therapeutic agent are less than 500 pascals.

Abstract: A catheter port adapted to be selectively secured topically to a patient's body about a site at which a catheter is to be inserted into the patient's body. The catheter port includes a cushion adapted to be secured to the patient's epidermis at its bottom surface about the site and at its top surface to a member, an inner tube having one portion mounted on the member and having another portion that is adapted to extend into the patient's body about the site for guiding movement of a catheter relative to the site and for preventing any portion of the catheter from ever contacting the patient's epidermis, an outer tube having a proximal end mounted on one of the member and inner tube, an intermediate portion extending away from the one of the member and the inner tube in a distal end and a septum mounted on the outer tube.

Abstract: Smart torquers are provided. Aspects of the smart torquers include: an engager for releasably engaging an elongated intravascular device; a communications module; a contact associated with the engager and configured to communicatively contact an elongated intravascular device engaged by the engager with the communications module; and a manipulator configured to allow a user to torque an elongated intravascular device engaged by the engager. Aspects of the invention further include methods of using the smart torquers, as well as systems and kits employed in such methods.

Abstract: Certain embodiments herein relate to an extension catheter for positioning through a conventional guiding catheter into the vasculature of a patient, the extension catheter having a distal tubular member and a proximal elongated shaft coupled to the distal tubular member, wherein the proximal shaft has a length or section containing at least one discontinuous or segmented structure, and further wherein such structures that can be modified or varied to modify the torsional compliance characteristics of the device. Further embodiments relate to a multi-layer catheter having a protective wrap at or near the distal end of the catheter.

Abstract: Method for fabricating a catheter including providing an inner tubular member formed from a first polymeric material, the inner tubular member having a distal section, a distal end, and a lumen defined therein by a first inner diameter; necking down at least a portion of the distal section of the inner tubular member to form a necked tip having a second inner diameter; and removing a portion of polymeric material from an inner surface along the necked tip to define a third inner diameter for the necked tip. The method can include positioning the distal section of the inner tubular member in a balloon having a working length, a distal neck, and a distal leg, with the distal end of the inner tubular member extending distally beyond a distal end of the distal leg, and coupling the distal leg of the balloon to at least a portion of the distal section of the inner tubular member.

Abstract: A support device configured to support post-surgical drain bulbs at locations adjacent to a body of a wearer. The support device including a band of flexible material having a first end and a second end defining a band length there between, the band further including a pair of D-rings positioned proximate to the first end of the band and sized to accommodate a portion of the band proximate to the second end of the band, one or more snap fastener parts positioned proximate to the second end of the band and configured to selectively couple to one or more snap fastener counterparts positioned along the band length between the first end and the second end, and a band of hook and loop fastener material fixedly coupled to an outer surface of the band along the length of the band from a point proximate to the first end to a point proximate to the second end and configured to selectively couple to one or more securement members comprised of a counterpart to the hook and loop fastener material.

Abstract: Systems and methods for systems and methods for focal cooling of the brain and spinal cord are disclosed. Some embodiments may be directed to a neuroprotection system that includes a cerebrospinal fluid processing platform. Embodiments may provide rapid and selective spinal cord hypothermia and drainage. Embodiments may be tailored to selective spinal cord cooling, pressure monitoring and automated drainage. Embodiments may enable local hypothermic neuroprotection, limit the stress of systemic cooling, minimize secondary neuronal damage and achieve maximal neuroprotection while at the same time improving workflow as a result of automated drainage. Embodiments may include a multi-lumen catheter, a drainage collection reservoir bag, a pump to circulate coolant, sensor hardware and controllers to modulate the flow of a heat transfer fluid for cooling to modulate therapeutic hypothermia and re-warming. Certain embodiments may include extracorporeal cooling of cerebrospinal fluid (CSF).

Abstract: A method and toolset capable of remotely moving a rotor of an implanted device in a first arcuate direction and detecting a first limit of travel, moving the rotor in a second, opposite direction and detecting a second limit of travel without altering the current performance setting of the implanted device, comparing the first and second limits of travel with known values for a plurality of selectable performance settings, and indicating the current performance setting of the implanted device.

Abstract: Ureteral stent devices having improved drug delivery capabilities are provided. The ureteral stent device includes a ureteral stent comprising two opposed ends, and a drug delivery component associated with at least one end of the ureteral stent. The drug delivery component includes a drug housing defining a drug reservoir containing a drug, wherein the drug housing is configured to release the drug in-vivo.

Abstract: A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction of an ionic concentration to an electronic voltage, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes/ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.

Abstract: The present invention is directed to a device that provides an implantable port, particularly for use with animal models, such as small animal models like mouse models. A microport device according to an embodiment of the present invention includes a reservoir and a catheter for delivery of substances held within the reservoir. The catheter can be barbed and can decrease in diameter from its proximal end to its distal end. The reservoir can include diaphragms for the delivery of substances to be held within the reservoir. The device can also include a sleeve that covers the device and a tip protector that covers the distal tip of the catheter.

Abstract: A vascular access port includes a base with a floor. A cap is engaged with the base to form a reservoir above the floor as a septum seals the reservoir in a fluid-tight manner. An outlet is in fluid communication with the reservoir. At least one of the base and cap is formed by metal injection molding. The cap and base may be engaged with a snap fit connection or a rotatable connection. The fluid communication may be along a non-tangential non-radial flow path. The flow path may be asymmetrical and may also include textured walls.

Abstract: This invention is directed to a sterile IV tube end cap comprising: a housing attached to a strip; an end cap received in the housing and removably attached to the strip; so that when the IV tube is attached to the end cap, the IV tube cannot be removed from the end cap without removing the end cap from the strip. The end cap can receive the male end of an IV tube wherein a portion of the IV tube is received in the housing and the IV tube is secured to the strip so that the IV tube cannot be removed from the end cap without removing the end cap from the strip.

Abstract: An electrical connector, in particular for a medical device that is intended to be secured to the skin of a user, is disclosed. The connector includes a base for solidly connecting to the device and a plug for solidly connecting to an electric conductor. The plug includes a connection means and the base includes a plurality of connection means, each being adapted to engage with the connection means of the plug in order to establish a connection between the base and the plug.

Abstract: An illustrative anchoring mechanism is provided for attachment to an implantable subcutaneous lead to facilitate anchoring at the distal tip of the lead. The anchoring mechanism is attached to an opening in a distal portion of a subcutaneous lead prior to implantation. The anchoring mechanism may be designed to avoid covering the sensing electrode of the subcutaneous lead, to prevent interference with sensing. Use of such an apparatus may reduce the number of incisions needed to perform implantation.

Abstract: A spinal catheter for insertion into the epidural space of a human or animal subject includes first and second lumens. A pressurized fluid can be discharged through the first lumen directly onto a tissue obstruction to form a partial/pilot or full/final opening in the tissue obstruction. If a full opening was not formed sufficient for passage of the stimulator lead, the distal-end portion of the stimulator lead can be inserted into the partial opening and then a pressurized fluid can be delivered through the second lumen and into a distensible balloon for expanding the balloon to clear the tissue obstruction sufficient for passage of the stimulator lead. In this way the catheter can be advanced past a tissue obstruction and into place for use within the epidural space, without having to remove and reinsert multiple surgical implements.

Abstract: Bacteria, cancer cells, fungus and other harmful cells located beneath the surface of a mammal body can be effectively destroyed by passing an electrical current through the area to be treated. Electrodes are positioned on either side of the area to be treated, for example, gums, fingers, arms, legs, feet and torso, and an electric current is caused to flow between the electrodes and through the area to be treated. The electric current will destroy the bacteria, cancer cells, fungus or other harmful cells.

Abstract: An iontophoretic drug delivery apparatus comprises an electrode unit comprising a plurality of iontophoresis electrodes and a plurality of tissue resistivity measurement electrodes; a programmable current unit configured to control a current that is supplied to the iontophoresis electrodes to thereby control the amount of drug delivered; an impedance detection unit comprising a detection mode that selectively measures a load resistance value between the iontophoresis electrodes or a tissue resistivity value between the tissue resistivity measurement electrodes so as to monitor the amount of drug delivered; and a control unit configured to control the programmable current unit by determining the amount of drug delivered or whether the drug is to be delivered, based on the load resistance or tissue resistivity value measured in the impedance detection unit.

Abstract: A cosmetic and/or therapeutic treatment of tissue, such as tooth, is disclosed that effects, for instance, whitening and tissue re-building through mineralisation. Further, a method of performing iontophoresis utilizing an aqueous composition of a remineralising agent to achieve mineralisation is disclosed, as well as a kit for performing the mineralization or re-mineralisation.

Abstract: In a system for retrieving an implanted device, a flared inner surface of a catheter tubular sidewall may define a distal-most opening of a device receptacle; the opening has a first diameter equal to that of the receptacle, and a second diameter, coincident with a distal-most edge of the tubular sidewall, and at least 5% greater than the receptacle diameter. Alternately, a retrieval tool in sliding engagement within a lumen of a catheter includes a shaft assembly, through which a snare member passes, and which includes a collapsible spring-biased perimeter sidewall; the sidewall defines a capture member passageway approximately coaxial, and in fluid communication with a lumen of the shaft assembly. A distal-most opening of the passageway has a spring-biased diameter that is greater than that of a distal-most opening of a device receptacle of the catheter, and a collapsed diameter that is less than the receptacle distal-most opening diameter.

Abstract: One aspect of the present disclosure relates to a system for electrical stimulation. A waveform generator can be configured to generate an electrical waveform. An electrode can be electrically coupled to the waveform generator and configured to deliver the electrical waveform to a nerve to reduce at least one reflex that affects a bodily function.

Abstract: A system for treatment of biological tissues is provided. The system includes a lens having a hollow, substantially hemispherical shape with an outer surface and an inner surface, the inner surface defining a substantially hemispherical cavity for inserting the biological tissues. The system further includes an antenna assembly for generating and directing electromagnetic radiation towards the outer surface. In the system, the lens is configured to direct the electromagnetic energy to an area in the cavity, a dielectric constant of the lens at the inner surface substantially matches a dielectric constant of the biological tissues, the dielectric constant monotonically increases from the outer surface to the inner surface, and the electromagnetic energy is generated via a series of pulses having a transient of less than about 1 nanosecond.

Abstract: A medical device performs a method for computing an estimate of a physiological variable. The method includes sensing a physiological signal and measuring an event of the physiological signal. The device initializes a value of a long-term metric of the event measurement, wherein the long-term metric corresponds to a time interval correlated to a response time of the physiological variable to changes in the event. The estimate of the long-term metric is updated in a memory of the medical device using a previous long-term metric and a current measurement of the event. The device detects a need for computing the physiological variable and computes an estimate of the physiological variable using the updated long-term metric.

Abstract: Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.

Abstract: Systems, devices, and methods for neurostimulation using a combination of implantable and external devices to treat pain are disclosed.

Abstract: A circuit includes first and second current control sub-circuits connected in series between a DC supply voltage node and a reference voltage node and third and fourth current control sub-circuits connected in series between the DC supply voltage node and the reference voltage node. The circuit also includes a DC/DC converter with a first input terminal coupled to the first load node between the first and second current control sub-circuits, a second input terminal coupled to a second load node between the third and fourth current control sub-circuits, a first output terminal, and a second output terminal. The circuit further includes output electrodes, a routing sub-circuit for selectively coupling the output electrodes to the output terminals, and a controller configured for operating the routing sub-circuit and the current control sub-circuits to cause the DC/DC converter to supply biphasic pulses for at least one of the pairs of output electrodes.

Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients. Stimulation from an implantable medical device (IMD) may be suspended in response to detecting a patient discomfort event, such as a cough, throat irritation, or voice alteration. The suspension period may be based on at least one of a severity level of the patient discomfort event and a patient physical state, such as being asleep or lying down. Detection of a patient discomfort event may be calibrated.

Abstract: A system for controlling a therapeutic device and/or environmental parameters can include one or more body worn sensor devices that detect and report one or more physical, physiological, or biological parameters of a person in an environment. The sensor devices can communicate sensor data indicative of the one or more physical, physiological, or biological parameters of a person to an external hub that processes the data and communicates with the therapeutic device to provide a therapy (e.g., neuromodulation, neurostimulation, or drug delivery) as a function of the sensor data. In some embodiments, the therapeutic device can be implanted in the person. In some embodiments, the therapeutic device can be in contact with the skin of the person. The sensor devices can also communicate to the hub that communicates with one or more devices to change the environment as a function of the sensor data.

Abstract: The invention is directed to a method of bonding a hermetically sealed electronics package to an electrode or a flexible circuit and the resulting electronics package, that is suitable for implantation in living tissue, such as for a retinal or cortical electrode array to enable restoration of sight to certain non-sighted individuals. The hermetically sealed electronics package is directly bonded to the flex circuit or electrode by electroplating a biocompatible material, such as platinum or gold, effectively forming a studbump connection, which bonds the flex circuit to the electronics package. The resulting electronic device is biocompatible and is suitable for long-term implantation in living tissue.

Abstract: The present invention is directed toward a detection architecture for use in implantable cardiac rhythm devices. The detection architecture of the present invention provides methods and devices for discriminating between arrhythmias. Moreover, by exploiting the enhanced specificity in the origin of the identified arrhythmia, the detection architecture can better discriminate between rhythms appropriate for device therapy and those that are not.

Abstract: A medical system for providing a defibrillation therapy to a patient includes a cardiac monitoring device (CMD) configured to sense and record physiological data indicative of the patient's cardiac function. The CMD includes a communication component. The system also includes an external therapy device configured to deliver defibrillation therapy, and configured to be positioned external to and supported by the patient. The external therapy device includes an external therapy device communication component. The CMD communication component and the external therapy device communication component are configured to operatively couple the CMD and the external therapy device to one another, so as to work as a system to detect and treat fibrillation.

Abstract: An external medical device is provided which is configured to provide a user with access to one or more training modules. The external medical device includes one or more electrodes configured to detect a cardiac activity of a patient, an audio and/or visual output, and a controller coupled to the audio and/or visual output. The controller is configured to: detect at least one of a predetermined event and a device use pattern; and responsive to detecting the at least one of the predetermined event and the device use pattern, provide the patient access to one or more training modules relating to a use or a configuration of the external medical device via the audio and/or visual output. The device can also include a user interface configured to provide access to at least one training module according to a schedule of training modules for the patient.

Abstract: A system for the physical manipulation of free magnetic rotors in a circulatory system using a remotely placed magnetic field-generating stator is provided. In one embodiment, the invention relates to the control of magnetic particles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. Examples of vascular occlusions targeted by the system include, but are not limited to, atherosclerotic plaques, including fibrous caps, fatty buildup, coronary occlusions, arterial stenosis, restenosis, vein thrombi, arterial thrombi, cerebral thrombi, embolisms, hemorrhages, other blood clots, and very small vessels.

Abstract: In certain aspects, the present disclosure is directed to a method of improving a patient's recovery after a neuro-ischemic event. The method can include identifying a patient who has suffered a neuro-ischemic event, and stimulating, for a period of time, a parasympathetic structure in the patient's cranium before, during, and/or after the patient undergoes a task-oriented therapy to improve the patient's recovery.

Abstract: A medical device for treating a skin of a patient includes: a radiation source configured to provide radiation; a collimator coupled to the radiation source; and an optical device for viewing a target area on the skin when a distal end of the medical device is covering the skin. A method of treating a skin of a patient includes: providing a treatment device having a distal end, a radiation source, and a collimator, wherein the distal end is configured for placement over the skin of the patient so that the skin of the patient is covered by the distal end of the treatment device; and providing an image of a target on the skin when the distal end of the treatment device is covering the skin of the patient.

Abstract: A method for quantifying radiation beam conformity includes: obtaining first information regarding a prescribed aperture; obtaining second information regarding an actual aperture defined by components of a collimator; and determining, using a processing unit, a metric based on the first information regarding the prescribed aperture and the second information regarding the actual aperture, wherein the metric indicates an amount of over-exposed aperture area, an amount of under-exposed aperture area, or both, and wherein the processing unit comprises one or more input for receiving the first and second information, and comprises a metric determination module configured to determine the metric based on the first information and the second information.

Abstract: Catheter-based devices and associated methods for immune system neuromodulation of human patients are disclosed herein. One aspect of the present technology is directed to methods of treating a human patient diagnosed with an immune system condition. The methods can include intravascularly positioning a neuromodulation catheter within a blood vessel proximate to neural fibers innervating an immune system organ of the patient. The method also includes reducing sympathetic neural activity in the patient by delivering energy to the neural fibers innervating the immune system organ via the neuromodulation catheter. Reducing sympathetic neural activity improves a measurable physiological parameter corresponding to the immune system condition of the patient.

Abstract: Methods for non-invasive fat reduction can include targeting a region of interest below a surface of skin, which contains fat and delivering ultrasound energy to the region of interest. The ultrasound energy generates a thermal lesion with said ultrasound energy on a fat cell. The lesion can create an opening in the surface of the fat cell, which allows the draining of a fluid out of the fat cell and through the opening. In addition, by applying ultrasound energy to fat cells to increase the temperature to between 43 degrees and 49 degrees, cell apoptosis can be realized, thereby resulting in reduction of fat.

Abstract: An adjustable face mask having a body conforming substantially to the facial structure of a wearer. The face mask is provided with a neck protector and removable filter and with a strip of fabric designed to push air down to the sides of the wearer's face in order to eliminate fogging of the wearer's goggles. The face mask can optionally provide neck protection with a descending neck member.

Abstract: A firefighting monitor includes logic circuitry for determining the reaction force caused by the flow of firefighting fluid therethrough. The reaction force may be communicated to structures remote from the monitor for taking appropriate actions in response to the reaction forces exceeding one or more criteria. The monitor may also use flow and nozzle data for calculating a reach of the stream of the fluid, and may transmit this reach data to a remote location. The monitor may also utilize multiple pressure sensor transducers positioned inside the monitor for determining the rate of fluid flow, rather than a paddle wheel-type sensor.

Abstract: A concealed fire sprinkler includes a main body, an arm extending along the main body and a receiving slot formed on the arm. A bottom cover is fixed by the arm at bottom of the main body. An elastic component is received in the receiving slot. Two ends of the elastic component contact with the arm and the bottom cover. Accordingly, the conventional problems that the temperature sensing speed of concealed fire sprinklers is not capable of increasing rapidly can be solved.

Abstract: A portable exercise system has a foldable perimeter frame comprising at least two elongated frame members that are joined by hinges. The hinges are joined to ends of the frame members, which ends are generally tubular. Each hinge has a cap-like body having an interior surface that defines a cavity configured to nestingly receive one of the ends of the frame members. A deformable plug is located within the central cavity of the one of the ends. A tightening mechanism is operated to expand the plug radially and thereby cause the end to expand radially such the generally tubular outer surface of the end frictionally engages the interior surface of the a cap-like body.

Abstract: A trampoline enclosure formed from a material such as netting has a door opening for entry into and exit from the trampoline enclosure and a fold down door panel with at least one resilient member acting to bias the door panel to return the door panel to a closed position from a folded down open position.

Abstract: A system for adjusting a load movable along a vertical direction for gymnastic machines provided with a frame, said system comprising a supporting member of said mobile load, provided with a plurality of adjustment holes, said movable load consisting of a plurality of weights arranged stacked and selectable, a selector member to be inserted in one of said adjustment holes of said supporting member, in order to select a group of said weights, adjusting said movable load and a string having an end fixed to said selector member, said system comprising tensioning means of said string, to keep said string in tension when said selector member is inserted in one hole of said plurality of adjustment holes, and to return said selector member when it is disengaged from said plurality of adjustment holes The system also concerns a tensioning and returning device.

Abstract: A convertible weight system includes a weight having a first and a second side. The first side has a threaded extension extending outwardly. The system includes a threaded chamber adapted to receive a second threaded extension. The threaded chamber is located on the second side of the weight. The system includes at least one spring adapted to extend from a first location on the weight. The system includes a spring socket adapted to receive a second spring. The spring socket is located at a second location. A connecting mechanism that includes a threaded extension extending outwardly from a first surface. The connecting mechanism includes a threaded chamber adapted to receive a second threaded extension for application in a kettlebell, barbell or dumbbell configuration.