Abstract: The present invention relates to methods of treating pruritic diseases, including but not limited to Contact dermatitis, Atopic Dermatitis, Drug induced delayed type cutaneous allergic reactions, Toxic epidermal necrolysis, Cutaneous T cell Lymphoma, Bullous pemphigoid, Alopecia wereata, Vitiligo, Acne Rosacea, Prurigo nodularis, Scleroderma, Herpes simplex virus, or combination thereof by administering IL-31 monoclonal antibodies. The invention provides the hybridomas that generate the monoclonal antibodies and the amino acid sequences of the variable regions of the monoclonal antibodies and chimeric antibodies comprising the amino acid sequences of the light and heavy chain variable regions.

Abstract: The disclosure provides compositions and methods comprising a sialoadhesin binding moiety for treating metabolic and genetic bone disease, especially for treating a bone disorder of hyper-resorption of bone and/or enhanced activation of osteoclasts.

Abstract: The invention provides anti-MCAM antibodies that inhibit the ability of human MCAM to bind a laminin alpha-4 chain and pharmaceutical compositions and pharmaceutical formulations incorporating the same for use in treatment or prophylaxis of giant cell arteritis, polymyalgia rheumatica (PMR) or Takayasu's arteritis, methods of generating such antibodies, and their use in the manufacture of medicaments for treatment of neuroinflammatory disease, autoimmune disease, or cancer.

Abstract: Provided herein are antibodies specific for integrin ?v?8 that change the conformation of ?8 so that, upon binding the ability of ?v?8 to induce release of active, mature TGF? peptide is inhibited.

Abstract: The present invention relates to the treatment of osteogenesis imperfecta with anti-Siglec-15 antibodies or antigen binding fragment thereof. Treatment of osteogenesis imperfecta type VI is particularly contemplated.

Abstract: Antibodies characterized by their variable sequences/CDRs which specifically bind to the Axl protein are described. Also disclosed are methods for the production and use of the anti-Axl antibodies.

Abstract: Combination of human antibodies that bind to human platelet-derived growth factor receptor alpha (PDGFR alpha), preferably olaratumab, and doxorubicin as a medicament for the treatment of soft tissue sarcoma.

Abstract: The invention relates to antibodies directed against CD127, the alpha chain of the interleukin 7 (IL-7) receptor IL-7R), and which have antagonist properties for IL-7-IL-7R interaction, may present cytotoxic activity against CD127 positive cells but do not increase the maturation of dendritic cells (DCs) induced by TSLP, a cytokine also using CD127 as part of its receptor. Alternatively, or in addition, these antibodies do not induce the internalization of CD127 and/or inhibit the IL7-induced internalization of CD127.

Abstract: The present invention provides antibodies that bind to the human glucagon receptor, designated GCGR and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human GCGR. The antibodies of the invention are useful for lowering blood glucose levels and blood ketone levels and are also useful for the treatment of diseases and disorders associated with one or more GCGR biological activities, including the treatment of diabetes, diabetic ketoacidosis and long-term complications associated with diabetes, or other metabolic disorders characterized in part by elevated blood glucose levels.

Abstract: The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human CD70 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.

Abstract: The present invention relates to multispecific antibodies, methods for their production, pharmaceutical compositions containing said antibodies and uses thereof.

Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

Abstract: This invention provides a composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a suitable carrier. This invention provides a pharmaceutical composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a pharmaceutically acceptable carrier. This invention also provides an antibody other than the monoclonal antibody 8H9 comprising the complementary determining regions of monoclonal antibody 8H9 or a derivative thereof, capable of binding to the same antigen as the monoclonal antibody 8H9. This invention provides a substance capable of competitively inhibiting the binding of monoclonal antibody 8H9. This invention also provides an isolated scFv of monoclonal antibody 8H9 or a derivative thereof. This invention also provides the 8H9 antigen.

Abstract: The present invention provides novel IgE antibodies useful for inhibiting or preventing metastatic cancer. Also provided are methods to inhibit tumor metastasis by modulating the activity of at least one non-tumor cell, treating a patient to inhibit or prevent tumor metastases of a primary solid tumor, treating metastatic carcinoma, reducing metastasis of carcinoma cells, and reducing the growth kinetics of a primary solid tumor or a metastasized cell or tumor.

Abstract: In one aspect, the disclosure provides cells and transgenic non-human mammals for the production of Fc fragments, as well as compositions and uses thereof.

Abstract: The present invention relates to an ErbB2-specific NK-92 cell or cell line containing a lentiviral vector encoding a chimeric antigen receptor and preferably two vector integration loci in its cellular genome. The present invention further relates to the use of the ErbB2-specific NK-92 cell or cell line in the prevention and/or treatment of cancer, preferably ErbB2-expressing cancers. The present invention further relates to the use of the ErbB2-specific NK-92 cell or cell line as targeted cell therapeutic agent and/or for adoptive cancer immunotherapy. The present invention further relates to a method for generating an ErbB2-specific NK-92 cell or cell line as well as to a method for identifying an ErbB2-specific NK-92 cell or cell line and to the ErbB2-specific NK-92 cell or cell line obtained or identified by the methods as well as their uses.

Abstract: Disclosed is an antibody which binds to paliperidone, which can be used to detect paliperidone in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of paliperidone, including multiplex detection of aripiprazole, olanzapine, quetiapine, risperidone and paliperidone in a single lateral flow assay device.

Abstract: Disclosed herein are methods and systems for purging a polymer product of volatiles. The methods and systems are particularly useful in the purging of a polyethylene polymer product produced in a fluidized bed reactor.

Abstract: Subject polymers have a plurality of repeating units having amino-bis-phosphonate functionality pendent groups of a polyacrylate, polymethacrylate, polyacrylamide, polymethacrylamide, or linear polyethyleneimine. The polymers are prepared from a plurality of monomers comprising amino-te-phosphonate functionality or from a polymer having NHBoc or active ester pendent groups that are subsequently transformed into the amino-bis-phosphonate comprising polymer. The amino-bis-phosphonate comprising polymers or their precursor polymers can be prepared by RAFT polymerization or by transformation of a preformed polymer. The amino-bis-phosphonate comprising polymers can be linear or branched polymers. The amino-bis-phosphonate comprising polymers can be complexed with metal ions. The metal ions can be a radionuclide and the amino-bis-phosphonate comprising polymer complexes can be used as radiotherapeutic agents.

Abstract: A process for producing ethylene polymer including compressing ethylene monomer in one or more compressors to a pressure from 1000 bar to 3000 bar; introducing the compressed ethylene monomer into one or more reactors; introducing a blend comprising an initiator and a modifier into the reactor where the ethylene monomer polymerizes forming a reaction mixture comprising unreacted ethylene monomer and ethylene polymer; and separating the ethylene polymer from the reaction mixture.

Abstract: In a method of forming patterns, an object layer is formed on a substrate. Guide patterns are formed on the object layer. A brush layer is formed using a brush polymer on surfaces of the guide patterns. The brush polymer includes at least one of a first brush polymer and a second brush polymer. The first brush polymer includes a hydrophobic repeating unit and a hydrophilic terminal group having at least two hydroxyl groups. The second brush polymer includes a hydrophobic repeating unit and a hydrophilic random repeating unit having a hydroxyl group. A self-aligned layer is formed using a block copolymer on the brush layer to form blocks aligned around the guide patterns. At least a portion of the blocks is transferred to the object layer.

Abstract: The invention relates to a process for the preparation of polypropylene having —a molecular weight (Mw) of 450,000-950,000, —a molecular weight distribution of 3-6, —a melt flow in the range of 7-14 dg/min measured with a load of 21.6 kg at 230° C. or 0.05-2 dg/min measured with a load of 2.16 kg at 230° C. and —a xylene soluble content of 2-6 wt % by converting propylene into the polypropylene without pre-polymerization in the presence of a polymerization catalyst under a condition where the volume ratio of H2 to propylene is at most 0.

Abstract: The present invention relates to a process for preparing a catalyst component for polymerization of an olefin comprising the steps of: i) contacting a compound R9zMgXz2-z wherein R9 is aromatic, aliphatic or cyclo-aliphatic group containing up to 20 carbon atoms, X is a halide, and z is in a range of larger than 0 and smaller than 2, with an alkoxy- or aryloky-containing silane compound pound to given first intermediate reaction product; ii) contacting the first intermediate reaction product with at least one activating compound selected from the group formed by electron donors and compounds of formula M(OR10)v-w(OR11)w, wherein M can be Ti, Zr, HI, Al or Si, and M(OR10)v-w(R11)w, wherein M is Si, each R10 and R11, independently, represent an alkyl, alkenyl or aryl group, v is the valency of M, v being either 3 or 4, and w is smaller than v, to give a second intermediate reaction product; and iii) contacting the second intermediate reaction product with a halogen-containing Ti-compound, a monoester as activat

Abstract: Disclosed herein are monolayers comprising alkylamine-gold nanoparticles that have tunable electrical and optical properties. Also disclosed is a method for forming the monolayers that comprises self-assembly of the nanoparticles.

Abstract: The instant invention provides an improved process for producing pelletized polymer compositions, and pelletized polymer compositions. The process for producing a pelletized polymer composition according to the present invention comprises: (1) polymerizing one or more alpha-olefins in one or more solution reactors thereby producing a molten polymer composition comprising one or more solvents; (2) removing at least a portion of said one or more solvents thereby forming a polymer composition having a low solvent content (typically less than 1,000 parts of solvent per million of polymer on a weight basis); (3) removing heat from said polymer composition having low solvent content to a temperature in the range of equal to or greater than the crystallization point of the polymer composition having low solvent content to less than or equal to a temperature in the range of from (the crystallization point of the polymer composition having low solvent content+20° C.

Abstract: Polyethylene resins having variable swell and excellent physical properties are provided. The polyethylene resins may be advantageously prepared using a single catalyst system.

Abstract: A method for producing an amphiphilic particle or an anisotropic particle includes combining seed particles with a monomer emulsion to obtain monomer-swollen seed particles, polymerizing the monomer-swollen seed particles to obtain polymerized monomer-swollen particles, and hydrolyzing the polymerized monomer-swollen particles. An amphiphilic particle is adapted to stabilize a first type of multiphasic mixture comprising a first aqueous phase having a first pH and a second type of multiphasic mixture comprising a second aqueous phase having a second pH.

Abstract: Use of a polymer as a secondary suspending agent in a suspension polymerisation reaction is provided. The polymer comprising (i) residues of at least one ester-containing monomer, the ester-containing monomer (s) comprising one polymerisable carbon-carbon double bond per monomer and an ester group, and (ii) residues of at least one monomer comprising a sulfonate, sulfonic acid, sulfonic ester, sulfonamide or sulfonyl halide group the monomer (s) comprising a sulfonate, sulfonic acid, sulfonic ester group, sulfonamide or sulfonyl halide group comprising one polymerisable carbon-carbon double bond per monomer and a sulfonate, sulfonic acid, sulfonic ester, sulfonamide or sulfonyl halide group, the polymer optionally being partially hydrolysed such that a proportion of said ester groups form alcohol groups, the degree of hydrolysis of the polymer being from 0 to 30 mol %.

Abstract: The present invention relates to a diacrylate compound represented by general formula (1), a composition thereof, and a cured product of the compound/composition. In the formula, R denotes a hydrogen atom or a methyl group; R1, R2, R3, and R4 each independently denote a C1-6 linear or branched alkyl group, with the proviso that R1, R2, R3, and R4 are not all methyl groups. The present invention provides: a novel diacrylate compound which can provide a cured product having an excellent balance of physical properties such as low curing shrinkage, flexibility, resistance to bending, and low curling properties, and which can be used as a photo- or thermal-radical polymerizable monomer; a composition of the compound; and a cured product of the compound/composition.

Abstract: Provided is a method for producing a multicomponent copolymer comprising copolymerizing a conjugated diene compound, a non-conjugated olefin compound, and an aromatic vinyl compound to produce a multicomponent copolymer having a main chain consisting of an acyclic structure.

Abstract: A packer unit to be used in an annular blowout preventer. The packer unit includes an elastomer body including a compound of a nitrile rubber base polymer having a polymer chain, and a quantity of fluorine atoms attached to the polymer chain. The compound includes between 50 and 60% of the nitrile elastomer, between 25 to 35% carbon black, and the rest includes other materials. The quantity of fluorine atoms comprises short-chain fluorocarbon chain molecules The quantity of fluorine atoms displaces at least an equal quantity of hydrogen atoms from the polymer chain when the elastomer body is fluorinated.

Abstract: The present invention relates to silicone hydrogels having a desirable balance of properties which can be formed without diluents. The silicone hydrogels are formed from reactive mixtures comprising at least one hydroxyl substituted, monofunctional polydialkylsiloxane monomer having between 2 and 120 dialkylsiloxane repeating units, at least one slow reacting hydrophilic monomer and at least one hydroxyl containing hydrophilic monomer.

Abstract: A polymer material for self-assembly of the present invention includes a multi-block copolymer containing a first polymer block with a structural unit having a specific structure as a main component and a second polymer block with a structural unit having a specific structure as a main component that are coupled with each other.

Abstract: The present invention provides a resin composition for a golf ball cover, wherein, since the resin composition for a golf ball cover according to the present invention minimizes changes in physical properties due to temperature changes and improves restitution characteristics, the resin composition for a golf ball cover may reduce performance deviations of a golf ball due to seasonal temperature changes and may improve a spin rate of the golf ball.

Abstract: Adducts and prepolymers comprising pendent alkyl groups are disclosed. Polythiol adducts prepared by reacting a polythiol with a ketone and urethane-extended polythiol adducts. The polythiol adducts can be terminated with isocyanate groups. Compositions comprising the isocyanate-terminated polythiol adducts, isocyanate-terminated sulfur-containing prepolymers, and diisocyanates can be combined with polyamine or polyepoxide curing agents to provide curable compositions. Cured compositions are suitable for aerospace coating and sealant applications. The compositions can also include a low specific gravity filler and, when cured, meet the requirements of aerospace sealant applications.

Abstract: A catalyst containing at least one amidine or guanidine group of formula (Ia) or (Ib), which is bound to a silicon atom of a siloxane residue. At room temperature, the catalyst is liquid and odourless. It is particularly suitable as a cross-linking catalyst for curable compositions, in particular for silane group-containing compositions. It is particularly good at accelerating the hardening of such compositions without impairing stability in storage, and displays little volatility but good compatibility. As a result, the compositions do not tend towards separation or migration or evaporation of the catalyst.

Abstract: An isocyanate reactive composition comprising At least one component selected from the group consisting of an isocyanate reactive component; a treating agent selected from the group consisting of cyclic urea substituted with at least one isocyanate reactive group, a free radical scavenger, or a polymer acid, or a mixture thereof; one or more amine components, each of said amine components having a given structure.

Abstract: Provided is a polymerizable composition for an optical material including (A) an amine having two or more secondary amino groups, (B) an isocyanate having two or more isocyanato groups, and (C) a thiol having three or more mercapto groups, in which the ratio (a/b) of the molar number a of amino groups in the amine (A) with respect to the molar number b of isocyanato groups in the isocyanate (B) is in the range of 0.10 to 0.60.

Abstract: A cyclopentene ring-opening polymer having, at a polymer chain end, a structure where a polymer chain and a group containing an alkoxysilyl group are bonded through —NH— and having a weight average molecular weight of 100,000 to 1,000,000, wherein the structure is a structure represented by the following general formula (1): pCP—Y1-NH—Y2-Si(OR1)a(R2)3-a (1) where, in the general formula (1), pCP represents a cyclopentene ring-opening polymer chain, Y1 represents a bivalent hydrocarbon group having 1 to 20 carbon atoms, each of R1 and R2 represents a hydrocarbon group having 1 to 20 carbon atoms, Y2 represents a bivalent hydrocarbon group having 1 to 20 carbon atoms in which —NH— may be interposed, and “a” is an integer of 1 to 3.

Abstract: The present invention relates to a method for using a combination of two kinds of thermal stabilizers in a production process in order to improve the thermal stability of biodegradable polyester resins, and to biodegradable polyester resin produced therefrom. In said method, two kinds of thermal stabilizers improve thermal stability by acting complementarily with each other. Thus, a high temperature reaction is possible, and due to an increase in the reactivity, the reaction time is shortened and the molecular weight is increased. In addition, the obtained resin can provide high quality products, since the acid value thereof is reduced to improve the hydrolysis resistance thereof, and the chromaticity thereof is enhanced to thereby be capable of preventing a yellowing phenomenon of the final product.

Abstract: The present invention relates to an alkyd resin comprising the condensation product of at least the following components (A) a polybasic acid, (B) a polyhydric alcohol, and (C) a linear C12-C60 hydrocarbo monocarboxylic acid, and optionally (D) at least one component other than any of components A to C characterized in that at least a part of the polybasic acid (A) is a (optionally hydrogenated) Diels Alder adduct of citraconic acid with C4-C14 conjugated diene, a (optionally hydrogenated) Diels Alder adduct of citraconic anhydride with C4-C14 conjugated diene, a half ester of such a Diels Alder adduct and/or a diester of such a Diels Alder adduct.

Abstract: The present invention relates to a method for manufacturing polydioxanone particles (PDO) for a filler, more particularly to a method for manufacturing polydioxanone particles, which includes a step of mixing a solution of polydioxanone dissolved in a perfluoroalcohol with a polymer emulsion containing a polyethylene oxide-polypropylene oxide-polyethylene oxide terpolymer at a predetermined ratio to generate polydioxanone particles and then recovering the polydioxanone particles through aging and washing. The polydioxanone particles manufactured by the manufacturing method of the present invention can be favorably used as an injection for regenerating skin tissues.

Abstract: A polyester including at least one furandicarboxylate unit, at least one saturated, linear or branched, diol unit including from 2 to 10 carbon atoms, and at least one bicyclic diol unit, the said bicyclic diol being chosen from: isosorbide, isoidide, isomannide, 2,3:4,5-di-O-methylene-galactitol, and 2,4:3,5-di-O-methylene-D-mannitol. The glass transition temperature of the polyester is greater than or equal to 90° C. Processes for preparing this polyester are also described.

Abstract: Various embodiments disclosed relate to electrochemical isomerization of muconic acid. In various embodiments, the present invention provides a method to prepare trans,trans-muconic acid. The method can include passing current through a catalytic cathode in a reactor including an aqueous acidic solution including cis,trans-muconic acid, a supporting electrolyte, and an anode, so as to isomerize the cis,trans-muconic acid to yield a product including trans trans-muconic acid.

Abstract: Polymeric compositions having improved flame retardance properties are disclosed. The compositions comprise a cross-linkable polycarbonate resin having a photoactive group derived from a benzophenone, a bromine source, and optionally a non-brominated and non-chlorinated flame retardant. The composition contains a minimum amount of bromine. Articles formed from the compositions have robust flame retardance properties and enhanced chemical resistance.

Abstract: Melt polymerization processes for producing photoactive additives are disclosed. The photoactive additives are cross-linkable polycarbonate resins formed from a benzophenone, a dihydroxy chain extender, a carbonate precursor, and a catalyst. The additives can be produced without the use of phosgene or dichloromethane, and can be cross-linked with other polymers upon exposure to UV radiation.

Abstract: A novel synthetic route to new classes of polymeric coupling agents using substituted epoxy monomers is reported. In the presence of an initiating agent and tris(pentafluorophenyl)borane catalyst, substituted epoxy monomers bearing polyalkylene oxide and trialkoxysilane moieties undergo a ring-opening polymerization. The polymerization is highly versatile and allows for the fine-tuning of functional, structural, and architectural features of the resulting polymeric coupling agents. These new polyalkylene oxides substituted with organosilyl groups are capable of bonding to and modifying inorganic surfaces. The products of this invention form thin hydrophilic films.

Abstract: Biocompatible hydrogels made from cross-linked catechol-borate ester polymers are disclosed, along with methods of synthesizing and using such hydrogels. The hydrogels of the present invention are prepared by boronic acid-catechol complexation between catechol-containing macromonomers and boronic acid-containing cross-linkers. The resulting hydrogels are pH-responsive and self-healing, and can be used in a number of different biomedical applications, including in surgical implants, in surgical adhesives, and in drug delivery systems is data provides further evidence of the viability of using the disclosed hydrogels for in vivo in biomedical applications.

Abstract: A semi-crystalline polyamide including at least one monomer resulting from the condensation of a diacid and of a diamine of formula AP.Y, the semi-crystalline polyamide having the following general formula (I): AP.Y/(A)m/(Pip.Y?)n/(B.Y?)q and the semi-crystalline polyamide having an Mp1 less than or equal to approximately 150° C., in particular less than or equal to approximately 130° C., in particular less than or equal to approximately 120° C. and/or a Tg less than or equal to approximately 60° C., in particular less than or equal to approximately 50° C., in particular less than or equal to approximately 40° C., as determined respectively by DSC according to standard ISO 11357-3 (2013) and ISO 11357-2 (2013).

Abstract: The present invention relates to a polymer comprising a repeating group having the structure of formula (I) wherein R, R1, R2, R3, R4, X, and s are as described herein and salt thereof. Also disclosed is a process of synthesizing such polymers.